-- dump date 20140619_044930 -- class Genbank::misc_feature -- table misc_feature_note -- id note 195103000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 195103000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 195103000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103000004 Walker A motif; other site 195103000005 ATP binding site [chemical binding]; other site 195103000006 Walker B motif; other site 195103000007 arginine finger; other site 195103000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 195103000009 DnaA box-binding interface [nucleotide binding]; other site 195103000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 195103000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 195103000012 putative DNA binding surface [nucleotide binding]; other site 195103000013 dimer interface [polypeptide binding]; other site 195103000014 beta-clamp/clamp loader binding surface; other site 195103000015 beta-clamp/translesion DNA polymerase binding surface; other site 195103000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103000017 RNA binding surface [nucleotide binding]; other site 195103000018 recombination protein F; Reviewed; Region: recF; PRK00064 195103000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 195103000020 Walker A/P-loop; other site 195103000021 ATP binding site [chemical binding]; other site 195103000022 Q-loop/lid; other site 195103000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103000024 ABC transporter signature motif; other site 195103000025 Walker B; other site 195103000026 D-loop; other site 195103000027 H-loop/switch region; other site 195103000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 195103000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103000030 Mg2+ binding site [ion binding]; other site 195103000031 G-X-G motif; other site 195103000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 195103000033 anchoring element; other site 195103000034 dimer interface [polypeptide binding]; other site 195103000035 ATP binding site [chemical binding]; other site 195103000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 195103000037 active site 195103000038 putative metal-binding site [ion binding]; other site 195103000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 195103000040 DNA gyrase subunit A; Validated; Region: PRK05560 195103000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 195103000042 CAP-like domain; other site 195103000043 active site 195103000044 primary dimer interface [polypeptide binding]; other site 195103000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195103000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195103000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195103000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195103000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195103000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195103000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 195103000052 hypothetical protein; Validated; Region: PRK00068 195103000053 Uncharacterized conserved protein [Function unknown]; Region: COG1615 195103000054 Predicted dehydrogenase [General function prediction only]; Region: COG0579 195103000055 hydroxyglutarate oxidase; Provisional; Region: PRK11728 195103000056 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 195103000057 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 195103000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 195103000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 195103000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 195103000061 dimer interface [polypeptide binding]; other site 195103000062 active site 195103000063 motif 1; other site 195103000064 motif 2; other site 195103000065 motif 3; other site 195103000066 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 195103000067 putative active site [active] 195103000068 putative metal binding site [ion binding]; other site 195103000069 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 195103000070 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 195103000071 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 195103000072 Part of AAA domain; Region: AAA_19; pfam13245 195103000073 Family description; Region: UvrD_C_2; pfam13538 195103000074 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 195103000075 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 195103000076 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 195103000077 active site 195103000078 NTP binding site [chemical binding]; other site 195103000079 metal binding triad [ion binding]; metal-binding site 195103000080 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 195103000081 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 195103000082 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 195103000083 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 195103000084 generic binding surface II; other site 195103000085 generic binding surface I; other site 195103000086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103000087 Zn2+ binding site [ion binding]; other site 195103000088 Mg2+ binding site [ion binding]; other site 195103000089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 195103000090 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 195103000091 peptidase T; Region: peptidase-T; TIGR01882 195103000092 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 195103000093 metal binding site [ion binding]; metal-binding site 195103000094 dimer interface [polypeptide binding]; other site 195103000095 EDD domain protein, DegV family; Region: DegV; TIGR00762 195103000096 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 195103000097 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 195103000098 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 195103000099 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 195103000100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 195103000101 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 195103000102 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 195103000103 Domain of unknown function DUF21; Region: DUF21; pfam01595 195103000104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 195103000105 Transporter associated domain; Region: CorC_HlyC; smart01091 195103000106 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 195103000107 nucleoside/Zn binding site; other site 195103000108 dimer interface [polypeptide binding]; other site 195103000109 catalytic motif [active] 195103000110 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 195103000111 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 195103000112 Uncharacterized conserved protein [Function unknown]; Region: COG0397 195103000113 hypothetical protein; Validated; Region: PRK00029 195103000114 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 195103000115 Zn binding site [ion binding]; other site 195103000116 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cd00113 195103000117 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 195103000118 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195103000119 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 195103000120 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195103000121 Predicted permeases [General function prediction only]; Region: COG0701 195103000122 Domain of unknown function (DUF1980); Region: DUF1980; pfam09323 195103000123 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 195103000124 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 195103000125 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 195103000126 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 195103000127 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 195103000128 folate binding site [chemical binding]; other site 195103000129 NADP+ binding site [chemical binding]; other site 195103000130 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 195103000131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103000132 Walker A motif; other site 195103000133 ATP binding site [chemical binding]; other site 195103000134 Walker B motif; other site 195103000135 arginine finger; other site 195103000136 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 195103000137 hypothetical protein; Validated; Region: PRK00153 195103000138 recombination protein RecR; Reviewed; Region: recR; PRK00076 195103000139 RecR protein; Region: RecR; pfam02132 195103000140 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 195103000141 putative active site [active] 195103000142 putative metal-binding site [ion binding]; other site 195103000143 tetramer interface [polypeptide binding]; other site 195103000144 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 195103000145 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 195103000146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103000147 catalytic residue [active] 195103000148 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 195103000149 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 195103000150 putative ligand binding site [chemical binding]; other site 195103000151 NAD binding site [chemical binding]; other site 195103000152 dimerization interface [polypeptide binding]; other site 195103000153 catalytic site [active] 195103000154 Uncharacterized conserved protein [Function unknown]; Region: COG4198 195103000155 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 195103000156 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 195103000157 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 195103000158 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 195103000159 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 195103000160 putative ATP binding site [chemical binding]; other site 195103000161 putative substrate interface [chemical binding]; other site 195103000162 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 195103000163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103000164 putative substrate translocation pore; other site 195103000165 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 195103000166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 195103000167 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 195103000168 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 195103000169 Substrate-binding site [chemical binding]; other site 195103000170 Substrate specificity [chemical binding]; other site 195103000171 CAT RNA binding domain; Region: CAT_RBD; smart01061 195103000172 transcriptional antiterminator BglG; Provisional; Region: PRK09772 195103000173 PRD domain; Region: PRD; pfam00874 195103000174 PRD domain; Region: PRD; pfam00874 195103000175 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 195103000176 HPr interaction site; other site 195103000177 glycerol kinase (GK) interaction site [polypeptide binding]; other site 195103000178 active site 195103000179 phosphorylation site [posttranslational modification] 195103000180 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 195103000181 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 195103000182 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 195103000183 active site turn [active] 195103000184 phosphorylation site [posttranslational modification] 195103000185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 195103000186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 195103000187 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 195103000188 elongation factor G; Reviewed; Region: PRK12740 195103000189 G1 box; other site 195103000190 putative GEF interaction site [polypeptide binding]; other site 195103000191 GTP/Mg2+ binding site [chemical binding]; other site 195103000192 Switch I region; other site 195103000193 G2 box; other site 195103000194 G3 box; other site 195103000195 Switch II region; other site 195103000196 G4 box; other site 195103000197 G5 box; other site 195103000198 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 195103000199 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 195103000200 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 195103000201 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 195103000202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103000203 nucleotide binding site [chemical binding]; other site 195103000204 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103000205 Rubredoxin; Region: Rubredoxin; pfam00301 195103000206 iron binding site [ion binding]; other site 195103000207 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 195103000208 Rubrerythrin [Energy production and conversion]; Region: COG1592 195103000209 diiron binding motif [ion binding]; other site 195103000210 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 195103000211 catalytic core [active] 195103000212 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 195103000213 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 195103000214 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 195103000215 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 195103000216 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 195103000217 putative active site [active] 195103000218 metal binding site [ion binding]; metal-binding site 195103000219 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 195103000220 intersubunit interface [polypeptide binding]; other site 195103000221 active site 195103000222 zinc binding site [ion binding]; other site 195103000223 Na+ binding site [ion binding]; other site 195103000224 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 195103000225 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 195103000226 substrate binding site [chemical binding]; other site 195103000227 ATP binding site [chemical binding]; other site 195103000228 KduI/IolB family; Region: KduI; pfam04962 195103000229 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 195103000230 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 195103000231 PYR/PP interface [polypeptide binding]; other site 195103000232 dimer interface [polypeptide binding]; other site 195103000233 TPP binding site [chemical binding]; other site 195103000234 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 195103000235 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 195103000236 TPP-binding site; other site 195103000237 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 195103000238 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 195103000239 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 195103000240 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 195103000241 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 195103000242 putative transporter; Provisional; Region: PRK10484 195103000243 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 195103000244 Na binding site [ion binding]; other site 195103000245 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 195103000246 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 195103000247 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 195103000248 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 195103000249 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 195103000250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 195103000251 substrate binding site [chemical binding]; other site 195103000252 oxyanion hole (OAH) forming residues; other site 195103000253 trimer interface [polypeptide binding]; other site 195103000254 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 195103000255 Coenzyme A transferase; Region: CoA_trans; smart00882 195103000256 Coenzyme A transferase; Region: CoA_trans; cl17247 195103000257 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 195103000258 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 195103000259 active site 195103000260 Uncharacterized conserved protein [Function unknown]; Region: COG1416 195103000261 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 195103000262 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 195103000263 dimer interface [polypeptide binding]; other site 195103000264 active site 195103000265 metal binding site [ion binding]; metal-binding site 195103000266 dihydroxyacetone kinase; Provisional; Region: PRK14479 195103000267 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 195103000268 DAK2 domain; Region: Dak2; pfam02734 195103000269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103000270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195103000271 putative substrate translocation pore; other site 195103000272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103000273 putative substrate translocation pore; other site 195103000274 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 195103000275 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 195103000276 NAD binding site [chemical binding]; other site 195103000277 dimer interface [polypeptide binding]; other site 195103000278 substrate binding site [chemical binding]; other site 195103000279 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195103000280 Protein of unknown function (DUF975); Region: DUF975; pfam06161 195103000281 Protein of unknown function (DUF975); Region: DUF975; pfam06161 195103000282 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 195103000283 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 195103000284 G1 box; other site 195103000285 GTP/Mg2+ binding site [chemical binding]; other site 195103000286 Switch I region; other site 195103000287 G2 box; other site 195103000288 Switch II region; other site 195103000289 G3 box; other site 195103000290 G4 box; other site 195103000291 G5 box; other site 195103000292 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 195103000293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103000294 FeS/SAM binding site; other site 195103000295 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 195103000296 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 195103000297 Predicted secreted protein [Function unknown]; Region: COG4086 195103000298 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 195103000299 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 195103000300 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 195103000301 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 195103000302 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 195103000303 active site 195103000304 metal binding site [ion binding]; metal-binding site 195103000305 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 195103000306 Double zinc ribbon; Region: DZR; pfam12773 195103000307 YARHG domain; Region: YARHG; pfam13308 195103000308 Double zinc ribbon; Region: DZR; pfam12773 195103000309 Predicted membrane protein [Function unknown]; Region: COG4640 195103000310 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 195103000311 Double zinc ribbon; Region: DZR; pfam12773 195103000312 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 195103000313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103000314 active site 195103000315 phosphorylation site [posttranslational modification] 195103000316 intermolecular recognition site; other site 195103000317 dimerization interface [polypeptide binding]; other site 195103000318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103000319 DNA binding site [nucleotide binding] 195103000320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103000321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103000322 ATP binding site [chemical binding]; other site 195103000323 Mg2+ binding site [ion binding]; other site 195103000324 G-X-G motif; other site 195103000325 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195103000326 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195103000327 Walker A/P-loop; other site 195103000328 ATP binding site [chemical binding]; other site 195103000329 Q-loop/lid; other site 195103000330 ABC transporter signature motif; other site 195103000331 Walker B; other site 195103000332 D-loop; other site 195103000333 H-loop/switch region; other site 195103000334 FtsX-like permease family; Region: FtsX; pfam02687 195103000335 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 195103000336 Cna protein B-type domain; Region: Cna_B; pfam05738 195103000337 Cna protein B-type domain; Region: Cna_B; pfam05738 195103000338 Cna protein B-type domain; Region: Cna_B; pfam05738 195103000339 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 195103000340 Cna protein B-type domain; Region: Cna_B; pfam05738 195103000341 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 195103000342 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 195103000343 active site 195103000344 catalytic site [active] 195103000345 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 195103000346 gating phenylalanine in ion channel; other site 195103000347 Predicted membrane protein [Function unknown]; Region: COG2855 195103000348 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 195103000349 EamA-like transporter family; Region: EamA; cl17759 195103000350 EamA-like transporter family; Region: EamA; cl17759 195103000351 competence damage-inducible protein A; Provisional; Region: PRK00549 195103000352 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 195103000353 putative MPT binding site; other site 195103000354 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 195103000355 CAAX protease self-immunity; Region: Abi; pfam02517 195103000356 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 195103000357 Rubrerythrin [Energy production and conversion]; Region: COG1592 195103000358 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 195103000359 binuclear metal center [ion binding]; other site 195103000360 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103000361 iron binding site [ion binding]; other site 195103000362 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 195103000363 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 195103000364 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103000365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103000366 Walker A/P-loop; other site 195103000367 ATP binding site [chemical binding]; other site 195103000368 Q-loop/lid; other site 195103000369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103000370 ABC transporter signature motif; other site 195103000371 Walker B; other site 195103000372 D-loop; other site 195103000373 ABC transporter; Region: ABC_tran_2; pfam12848 195103000374 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103000375 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 195103000376 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 195103000377 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 195103000378 catalytic residues [active] 195103000379 catalytic nucleophile [active] 195103000380 Recombinase; Region: Recombinase; pfam07508 195103000381 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 195103000382 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 195103000383 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 195103000384 cofactor binding site; other site 195103000385 DNA binding site [nucleotide binding] 195103000386 substrate interaction site [chemical binding]; other site 195103000387 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 195103000388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 195103000389 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 195103000390 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 195103000391 Cna protein B-type domain; Region: Cna_B; pfam05738 195103000392 Cna protein B-type domain; Region: Cna_B; pfam05738 195103000393 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 195103000394 Cna protein B-type domain; Region: Cna_B; pfam05738 195103000395 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 195103000396 active site 195103000397 catalytic site [active] 195103000398 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 195103000399 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 195103000400 Uncharacterized conserved protein [Function unknown]; Region: COG0398 195103000401 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103000402 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 195103000403 conserved hypothetical protein, ribA/ribD-fused; Region: ribofla_fusion; TIGR02464 195103000404 Mga helix-turn-helix domain; Region: Mga; pfam05043 195103000405 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 195103000406 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 195103000407 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 195103000408 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 195103000409 oligomer interface [polypeptide binding]; other site 195103000410 inner membrane transporter YjeM; Provisional; Region: PRK15238 195103000411 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 195103000412 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 195103000413 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 195103000414 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 195103000415 arginine deiminase; Provisional; Region: PRK01388 195103000416 ornithine carbamoyltransferase; Provisional; Region: PRK04284 195103000417 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 195103000418 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 195103000419 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 195103000420 Spore germination protein; Region: Spore_permease; cl17796 195103000421 carbamate kinase; Reviewed; Region: PRK12686 195103000422 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 195103000423 putative substrate binding site [chemical binding]; other site 195103000424 nucleotide binding site [chemical binding]; other site 195103000425 nucleotide binding site [chemical binding]; other site 195103000426 homodimer interface [polypeptide binding]; other site 195103000427 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 195103000428 Arginine repressor [Transcription]; Region: ArgR; COG1438 195103000429 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 195103000430 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 195103000431 Collagenase; Region: Peptidase_M9; pfam01752 195103000432 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 195103000433 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 195103000434 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 195103000435 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 195103000436 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 195103000437 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 195103000438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103000439 S-adenosylmethionine binding site [chemical binding]; other site 195103000440 cystathionine beta-lyase; Provisional; Region: PRK07671 195103000441 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 195103000442 homodimer interface [polypeptide binding]; other site 195103000443 substrate-cofactor binding pocket; other site 195103000444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103000445 catalytic residue [active] 195103000446 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 195103000447 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 195103000448 dimer interface [polypeptide binding]; other site 195103000449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103000450 catalytic residue [active] 195103000451 S-ribosylhomocysteinase; Provisional; Region: PRK02260 195103000452 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 195103000453 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 195103000454 substrate binding pocket [chemical binding]; other site 195103000455 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 195103000456 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 195103000457 ABC-2 family transporter protein; Region: ABC2_membrane_6; pfam06182 195103000458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 195103000459 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 195103000460 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 195103000461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103000462 Walker A/P-loop; other site 195103000463 ATP binding site [chemical binding]; other site 195103000464 Q-loop/lid; other site 195103000465 ABC transporter signature motif; other site 195103000466 Walker B; other site 195103000467 D-loop; other site 195103000468 H-loop/switch region; other site 195103000469 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 195103000470 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 195103000471 dimer interface [polypeptide binding]; other site 195103000472 FMN binding site [chemical binding]; other site 195103000473 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 195103000474 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 195103000475 putative active site cavity [active] 195103000476 N-acetylneuraminate lyase; Provisional; Region: PRK04147 195103000477 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 195103000478 inhibitor site; inhibition site 195103000479 active site 195103000480 dimer interface [polypeptide binding]; other site 195103000481 catalytic residue [active] 195103000482 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 195103000483 Na binding site [ion binding]; other site 195103000484 Domain of unknown function (DUF386); Region: DUF386; cl01047 195103000485 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 195103000486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103000487 nucleotide binding site [chemical binding]; other site 195103000488 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 195103000489 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 195103000490 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 195103000491 putative active site [active] 195103000492 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 195103000493 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103000494 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cd00057 195103000495 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 195103000496 sugar binding site [chemical binding]; other site 195103000497 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103000498 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 195103000499 active site 195103000500 catalytic site [active] 195103000501 cobalt transport protein CbiM; Validated; Region: PRK08319 195103000502 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 195103000503 cobalt transport protein CbiN; Provisional; Region: PRK02898 195103000504 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 195103000505 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636 195103000506 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 195103000507 Walker A/P-loop; other site 195103000508 ATP binding site [chemical binding]; other site 195103000509 Q-loop/lid; other site 195103000510 ABC transporter signature motif; other site 195103000511 Walker B; other site 195103000512 D-loop; other site 195103000513 H-loop/switch region; other site 195103000514 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 195103000515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 195103000516 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195103000517 Peptidase family M23; Region: Peptidase_M23; pfam01551 195103000518 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 195103000519 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 195103000520 putative trimer interface [polypeptide binding]; other site 195103000521 putative CoA binding site [chemical binding]; other site 195103000522 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 195103000523 putative homodimer interface [polypeptide binding]; other site 195103000524 putative homotetramer interface [polypeptide binding]; other site 195103000525 putative allosteric switch controlling residues; other site 195103000526 putative metal binding site [ion binding]; other site 195103000527 putative homodimer-homodimer interface [polypeptide binding]; other site 195103000528 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 195103000529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195103000530 putative active site [active] 195103000531 heme pocket [chemical binding]; other site 195103000532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103000533 dimer interface [polypeptide binding]; other site 195103000534 phosphorylation site [posttranslational modification] 195103000535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103000536 ATP binding site [chemical binding]; other site 195103000537 Mg2+ binding site [ion binding]; other site 195103000538 G-X-G motif; other site 195103000539 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 195103000540 Acyltransferase family; Region: Acyl_transf_3; pfam01757 195103000541 Conserved TM helix; Region: TM_helix; pfam05552 195103000542 Mechanosensitive ion channel; Region: MS_channel; pfam00924 195103000543 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 195103000544 heme binding pocket [chemical binding]; other site 195103000545 heme ligand [chemical binding]; other site 195103000546 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 195103000547 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 195103000548 active site 195103000549 metal binding site [ion binding]; metal-binding site 195103000550 DNA binding site [nucleotide binding] 195103000551 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 195103000552 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 195103000553 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 195103000554 Walker A/P-loop; other site 195103000555 ATP binding site [chemical binding]; other site 195103000556 Q-loop/lid; other site 195103000557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103000558 ABC transporter signature motif; other site 195103000559 Walker B; other site 195103000560 D-loop; other site 195103000561 H-loop/switch region; other site 195103000562 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 195103000563 propionate/acetate kinase; Provisional; Region: PRK12379 195103000564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103000565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103000566 NEAr Transporter domain; Region: NEAT; smart00725 195103000567 heme-binding site [chemical binding]; other site 195103000568 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 195103000569 heme-binding site [chemical binding]; other site 195103000570 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 195103000571 heme-binding site [chemical binding]; other site 195103000572 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 195103000573 heme-binding site [chemical binding]; other site 195103000574 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 195103000575 heme-binding site [chemical binding]; other site 195103000576 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 195103000577 active site 195103000578 catalytic site [active] 195103000579 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 195103000580 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 195103000581 putative ligand binding residues [chemical binding]; other site 195103000582 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 195103000583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195103000584 ABC-ATPase subunit interface; other site 195103000585 dimer interface [polypeptide binding]; other site 195103000586 putative PBP binding regions; other site 195103000587 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 195103000588 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 195103000589 Walker A/P-loop; other site 195103000590 ATP binding site [chemical binding]; other site 195103000591 Q-loop/lid; other site 195103000592 ABC transporter signature motif; other site 195103000593 Walker B; other site 195103000594 D-loop; other site 195103000595 H-loop/switch region; other site 195103000596 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 195103000597 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103000598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103000599 Walker A/P-loop; other site 195103000600 ATP binding site [chemical binding]; other site 195103000601 Q-loop/lid; other site 195103000602 ABC transporter signature motif; other site 195103000603 Walker B; other site 195103000604 D-loop; other site 195103000605 H-loop/switch region; other site 195103000606 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103000607 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103000608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103000609 Walker A/P-loop; other site 195103000610 ATP binding site [chemical binding]; other site 195103000611 Q-loop/lid; other site 195103000612 ABC transporter signature motif; other site 195103000613 Walker B; other site 195103000614 D-loop; other site 195103000615 H-loop/switch region; other site 195103000616 Protein of unknown function (DUF454); Region: DUF454; cl01063 195103000617 hypothetical protein; Provisional; Region: PRK10410 195103000618 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 195103000619 arylsulfatase; Provisional; Region: PRK13759 195103000620 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 195103000621 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 195103000622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103000623 putative substrate translocation pore; other site 195103000624 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 195103000625 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 195103000626 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 195103000627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103000628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103000629 dimerization interface [polypeptide binding]; other site 195103000630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103000631 dimer interface [polypeptide binding]; other site 195103000632 phosphorylation site [posttranslational modification] 195103000633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103000634 ATP binding site [chemical binding]; other site 195103000635 Mg2+ binding site [ion binding]; other site 195103000636 G-X-G motif; other site 195103000637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103000638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103000639 active site 195103000640 phosphorylation site [posttranslational modification] 195103000641 intermolecular recognition site; other site 195103000642 dimerization interface [polypeptide binding]; other site 195103000643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103000644 DNA binding site [nucleotide binding] 195103000645 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 195103000646 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 195103000647 Adhesin lipoprotein; Region: Lipoprotein_7; pfam01540 195103000648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 195103000649 ligand binding site [chemical binding]; other site 195103000650 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 195103000651 conserved hypothetical integral membrane protein; Region: TIGR03766 195103000652 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 195103000653 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195103000654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195103000655 metal binding site [ion binding]; metal-binding site 195103000656 active site 195103000657 I-site; other site 195103000658 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 195103000659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103000660 binding surface 195103000661 Tetratricopeptide repeat; Region: TPR_16; pfam13432 195103000662 TPR motif; other site 195103000663 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 195103000664 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 195103000665 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 195103000666 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 195103000667 nucleotide binding site [chemical binding]; other site 195103000668 putative NEF/HSP70 interaction site [polypeptide binding]; other site 195103000669 SBD interface [polypeptide binding]; other site 195103000670 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 195103000671 Coat F domain; Region: Coat_F; pfam07875 195103000672 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 195103000673 NAD-dependent deacetylase; Provisional; Region: PRK00481 195103000674 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 195103000675 NAD+ binding site [chemical binding]; other site 195103000676 substrate binding site [chemical binding]; other site 195103000677 putative Zn binding site [ion binding]; other site 195103000678 Uncharacterized conserved protein [Function unknown]; Region: COG4748 195103000679 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 195103000680 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 195103000681 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 195103000682 active site 195103000683 substrate binding site [chemical binding]; other site 195103000684 trimer interface [polypeptide binding]; other site 195103000685 CoA binding site [chemical binding]; other site 195103000686 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 195103000687 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 195103000688 Mechanosensitive ion channel; Region: MS_channel; pfam00924 195103000689 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 195103000690 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 195103000691 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 195103000692 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 195103000693 ligand binding site [chemical binding]; other site 195103000694 active site 195103000695 UGI interface [polypeptide binding]; other site 195103000696 catalytic site [active] 195103000697 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 195103000698 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 195103000699 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 195103000700 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 195103000701 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 195103000702 catalytic triad [active] 195103000703 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 195103000704 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 195103000705 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 195103000706 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 195103000707 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 195103000708 Walker A/P-loop; other site 195103000709 ATP binding site [chemical binding]; other site 195103000710 Q-loop/lid; other site 195103000711 ABC transporter signature motif; other site 195103000712 Walker B; other site 195103000713 D-loop; other site 195103000714 H-loop/switch region; other site 195103000715 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 195103000716 putative carbohydrate binding site [chemical binding]; other site 195103000717 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 195103000718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103000719 putative homodimer interface [polypeptide binding]; other site 195103000720 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 195103000721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103000722 putative homodimer interface [polypeptide binding]; other site 195103000723 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 195103000724 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 195103000725 Walker A/P-loop; other site 195103000726 ATP binding site [chemical binding]; other site 195103000727 Q-loop/lid; other site 195103000728 ABC transporter signature motif; other site 195103000729 Walker B; other site 195103000730 D-loop; other site 195103000731 H-loop/switch region; other site 195103000732 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 195103000733 putative carbohydrate binding site [chemical binding]; other site 195103000734 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 195103000735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103000736 putative homodimer interface [polypeptide binding]; other site 195103000737 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 195103000738 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195103000739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103000740 motif II; other site 195103000741 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 195103000742 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 195103000743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 195103000744 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 195103000745 NlpC/P60 family; Region: NLPC_P60; pfam00877 195103000746 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 195103000747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103000748 S-adenosylmethionine binding site [chemical binding]; other site 195103000749 Predicted methyltransferases [General function prediction only]; Region: COG0313 195103000750 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 195103000751 putative SAM binding site [chemical binding]; other site 195103000752 putative homodimer interface [polypeptide binding]; other site 195103000753 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 195103000754 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 195103000755 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 195103000756 active site 195103000757 catalytic residues [active] 195103000758 Transcriptional regulator [Transcription]; Region: LytR; COG1316 195103000759 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 195103000760 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 195103000761 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 195103000762 NAD binding site [chemical binding]; other site 195103000763 homodimer interface [polypeptide binding]; other site 195103000764 active site 195103000765 substrate binding site [chemical binding]; other site 195103000766 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 195103000767 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 195103000768 dimer interface [polypeptide binding]; other site 195103000769 ssDNA binding site [nucleotide binding]; other site 195103000770 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195103000771 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 195103000772 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 195103000773 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 195103000774 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 195103000775 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 195103000776 putative active site [active] 195103000777 FOG: PKD repeat [General function prediction only]; Region: COG3291 195103000778 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 195103000779 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103000780 sugar binding site [chemical binding]; other site 195103000781 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103000782 Interdomain contacts; other site 195103000783 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 195103000784 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 195103000785 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 195103000786 putative substrate binding site [chemical binding]; other site 195103000787 putative ATP binding site [chemical binding]; other site 195103000788 PemK-like protein; Region: PemK; pfam02452 195103000789 transketolase; Reviewed; Region: PRK05899 195103000790 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 195103000791 TPP-binding site [chemical binding]; other site 195103000792 dimer interface [polypeptide binding]; other site 195103000793 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 195103000794 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 195103000795 PYR/PP interface [polypeptide binding]; other site 195103000796 dimer interface [polypeptide binding]; other site 195103000797 TPP binding site [chemical binding]; other site 195103000798 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 195103000799 Uncharacterized conserved protein [Function unknown]; Region: COG1284 195103000800 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103000801 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103000802 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 195103000803 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 195103000804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103000805 Walker A/P-loop; other site 195103000806 ATP binding site [chemical binding]; other site 195103000807 Q-loop/lid; other site 195103000808 ABC transporter signature motif; other site 195103000809 Walker B; other site 195103000810 D-loop; other site 195103000811 H-loop/switch region; other site 195103000812 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 195103000813 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 195103000814 FtsX-like permease family; Region: FtsX; pfam02687 195103000815 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 195103000816 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 195103000817 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 195103000818 protein binding site [polypeptide binding]; other site 195103000819 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 195103000820 Catalytic dyad [active] 195103000821 excinuclease ABC subunit B; Provisional; Region: PRK05298 195103000822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103000823 ATP binding site [chemical binding]; other site 195103000824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103000825 nucleotide binding region [chemical binding]; other site 195103000826 ATP-binding site [chemical binding]; other site 195103000827 Ultra-violet resistance protein B; Region: UvrB; pfam12344 195103000828 UvrB/uvrC motif; Region: UVR; pfam02151 195103000829 EDD domain protein, DegV family; Region: DegV; TIGR00762 195103000830 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 195103000831 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 195103000832 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 195103000833 Walker A/P-loop; other site 195103000834 ATP binding site [chemical binding]; other site 195103000835 Q-loop/lid; other site 195103000836 ABC transporter signature motif; other site 195103000837 Walker B; other site 195103000838 D-loop; other site 195103000839 H-loop/switch region; other site 195103000840 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 195103000841 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 195103000842 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 195103000843 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 195103000844 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 195103000845 Walker A/P-loop; other site 195103000846 ATP binding site [chemical binding]; other site 195103000847 Q-loop/lid; other site 195103000848 ABC transporter signature motif; other site 195103000849 Walker B; other site 195103000850 D-loop; other site 195103000851 H-loop/switch region; other site 195103000852 Transcriptional regulators [Transcription]; Region: FadR; COG2186 195103000853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103000854 DNA-binding site [nucleotide binding]; DNA binding site 195103000855 FCD domain; Region: FCD; pfam07729 195103000856 L-lactate permease; Region: Lactate_perm; cl00701 195103000857 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 195103000858 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 195103000859 Ligand binding site [chemical binding]; other site 195103000860 Electron transfer flavoprotein domain; Region: ETF; pfam01012 195103000861 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 195103000862 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 195103000863 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 195103000864 FAD binding domain; Region: FAD_binding_4; pfam01565 195103000865 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 195103000866 TIGR03987 family protein; Region: TIGR03987 195103000867 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 195103000868 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 195103000869 Catalytic site [active] 195103000870 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 195103000871 Protein of unknown function (DUF975); Region: DUF975; pfam06161 195103000872 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195103000873 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103000874 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 195103000875 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 195103000876 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195103000877 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 195103000878 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 195103000879 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 195103000880 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 195103000881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103000882 active site 195103000883 EamA-like transporter family; Region: EamA; pfam00892 195103000884 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 195103000885 EamA-like transporter family; Region: EamA; pfam00892 195103000886 amino acid transporter; Region: 2A0306; TIGR00909 195103000887 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 195103000888 Domain of unknown function (DUF389); Region: DUF389; pfam04087 195103000889 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 195103000890 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 195103000891 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 195103000892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103000893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103000894 homodimer interface [polypeptide binding]; other site 195103000895 catalytic residue [active] 195103000896 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 195103000897 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 195103000898 DNA binding site [nucleotide binding] 195103000899 active site 195103000900 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 195103000901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103000902 ATP binding site [chemical binding]; other site 195103000903 putative Mg++ binding site [ion binding]; other site 195103000904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103000905 nucleotide binding region [chemical binding]; other site 195103000906 ATP-binding site [chemical binding]; other site 195103000907 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 195103000908 HRDC domain; Region: HRDC; pfam00570 195103000909 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 195103000910 Amidinotransferase; Region: Amidinotransf; pfam02274 195103000911 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103000912 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 195103000913 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 195103000914 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 195103000915 DNA binding residues [nucleotide binding] 195103000916 dimer interface [polypeptide binding]; other site 195103000917 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 195103000918 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 195103000919 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 195103000920 Membrane protein of unknown function; Region: DUF360; pfam04020 195103000921 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 195103000922 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195103000923 ligand binding site [chemical binding]; other site 195103000924 flexible hinge region; other site 195103000925 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 195103000926 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 195103000927 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 195103000928 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 195103000929 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 195103000930 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 195103000931 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 195103000932 phosphopeptide binding site; other site 195103000933 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 195103000934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 195103000935 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 195103000936 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 195103000937 GIY-YIG motif/motif A; other site 195103000938 active site 195103000939 catalytic site [active] 195103000940 putative DNA binding site [nucleotide binding]; other site 195103000941 metal binding site [ion binding]; metal-binding site 195103000942 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 195103000943 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 195103000944 FAD binding domain; Region: FAD_binding_4; pfam01565 195103000945 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 195103000946 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 195103000947 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 195103000948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 195103000949 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 195103000950 6-phosphofructokinase; Provisional; Region: PRK03202 195103000951 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 195103000952 active site 195103000953 ADP/pyrophosphate binding site [chemical binding]; other site 195103000954 dimerization interface [polypeptide binding]; other site 195103000955 allosteric effector site; other site 195103000956 fructose-1,6-bisphosphate binding site; other site 195103000957 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 195103000958 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 195103000959 domain interfaces; other site 195103000960 active site 195103000961 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 195103000962 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 195103000963 classical (c) SDRs; Region: SDR_c; cd05233 195103000964 NAD(P) binding site [chemical binding]; other site 195103000965 active site 195103000966 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 195103000967 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 195103000968 putative active site [active] 195103000969 catalytic site [active] 195103000970 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 195103000971 putative active site [active] 195103000972 catalytic site [active] 195103000973 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 195103000974 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 195103000975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103000976 DNA-binding site [nucleotide binding]; DNA binding site 195103000977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103000978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103000979 homodimer interface [polypeptide binding]; other site 195103000980 catalytic residue [active] 195103000981 TRAM domain; Region: TRAM; cl01282 195103000982 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 195103000983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103000984 S-adenosylmethionine binding site [chemical binding]; other site 195103000985 Nuclease-related domain; Region: NERD; pfam08378 195103000986 Family description; Region: UvrD_C_2; pfam13538 195103000987 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 195103000988 DNA methylase; Region: N6_N4_Mtase; pfam01555 195103000989 DNA methylase; Region: N6_N4_Mtase; cl17433 195103000990 Restriction endonuclease [Defense mechanisms]; Region: COG3587 195103000991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103000992 ATP binding site [chemical binding]; other site 195103000993 putative Mg++ binding site [ion binding]; other site 195103000994 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 195103000995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 195103000996 myosin-cross-reactive antigen; Provisional; Region: PRK13977 195103000997 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103000998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103000999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103001000 Walker A/P-loop; other site 195103001001 ATP binding site [chemical binding]; other site 195103001002 Q-loop/lid; other site 195103001003 ABC transporter signature motif; other site 195103001004 Walker B; other site 195103001005 D-loop; other site 195103001006 H-loop/switch region; other site 195103001007 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103001008 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103001009 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 195103001010 Walker A/P-loop; other site 195103001011 ATP binding site [chemical binding]; other site 195103001012 Q-loop/lid; other site 195103001013 ABC transporter signature motif; other site 195103001014 Walker B; other site 195103001015 D-loop; other site 195103001016 H-loop/switch region; other site 195103001017 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 195103001018 dinuclear metal binding motif [ion binding]; other site 195103001019 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 195103001020 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 195103001021 active site 195103001022 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103001023 Bacterial SH3 domain homologues; Region: SH3b; smart00287 195103001024 Holin family; Region: Phage_holin_4; pfam05105 195103001025 putative oxidoreductase; Provisional; Region: PRK11445 195103001026 TrkA-N domain; Region: TrkA_N; pfam02254 195103001027 hypothetical protein; Provisional; Region: PRK07236 195103001028 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 195103001029 putative active site [active] 195103001030 putative metal binding site [ion binding]; other site 195103001031 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 195103001032 classical (c) SDRs; Region: SDR_c; cd05233 195103001033 NAD(P) binding site [chemical binding]; other site 195103001034 active site 195103001035 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 195103001036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103001037 DNA-binding site [nucleotide binding]; DNA binding site 195103001038 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 195103001039 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 195103001040 phosphopentomutase; Provisional; Region: PRK05362 195103001041 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 195103001042 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 195103001043 histidine decarboxylase, pyruvoyl type; Region: hisDCase_pyru; TIGR00541 195103001044 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 195103001045 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 195103001046 putative active site [active] 195103001047 putative metal binding site [ion binding]; other site 195103001048 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 195103001049 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 195103001050 Quinolinate synthetase A protein; Region: NadA; pfam02445 195103001051 L-aspartate oxidase; Provisional; Region: PRK06175 195103001052 FAD binding domain; Region: FAD_binding_2; pfam00890 195103001053 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 195103001054 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 195103001055 dimerization interface [polypeptide binding]; other site 195103001056 active site 195103001057 xanthine permease; Region: pbuX; TIGR03173 195103001058 purine nucleoside phosphorylase; Provisional; Region: PRK08202 195103001059 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 195103001060 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195103001061 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 195103001062 ligand binding site [chemical binding]; other site 195103001063 flexible hinge region; other site 195103001064 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 195103001065 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 195103001066 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 195103001067 YcxB-like protein; Region: YcxB; pfam14317 195103001068 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 195103001069 Uncharacterized conserved protein [Function unknown]; Region: COG1284 195103001070 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103001071 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103001072 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 195103001073 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 195103001074 substrate binding site [chemical binding]; other site 195103001075 catalytic residues [active] 195103001076 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 195103001077 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 195103001078 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 195103001079 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 195103001080 NADP binding site [chemical binding]; other site 195103001081 homodimer interface [polypeptide binding]; other site 195103001082 active site 195103001083 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 195103001084 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 195103001085 active site 195103001086 intersubunit interface [polypeptide binding]; other site 195103001087 catalytic residue [active] 195103001088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 195103001089 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 195103001090 substrate binding site [chemical binding]; other site 195103001091 ATP binding site [chemical binding]; other site 195103001092 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 195103001093 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 195103001094 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 195103001095 active site 195103001096 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 195103001097 active site 195103001098 phosphorylation site [posttranslational modification] 195103001099 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 195103001100 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 195103001101 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 195103001102 active pocket/dimerization site; other site 195103001103 active site 195103001104 phosphorylation site [posttranslational modification] 195103001105 Preprotein translocase subunit; Region: YajC; pfam02699 195103001106 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 195103001107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103001108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103001109 DNA binding site [nucleotide binding] 195103001110 domain linker motif; other site 195103001111 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 195103001112 putative dimerization interface [polypeptide binding]; other site 195103001113 putative ligand binding site [chemical binding]; other site 195103001114 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 195103001115 FAD binding domain; Region: FAD_binding_4; pfam01565 195103001116 Berberine and berberine like; Region: BBE; pfam08031 195103001117 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 195103001118 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 195103001119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001120 active site 195103001121 motif I; other site 195103001122 motif II; other site 195103001123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001124 Predicted dehydrogenase [General function prediction only]; Region: COG0579 195103001125 hydroxyglutarate oxidase; Provisional; Region: PRK11728 195103001126 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 195103001127 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 195103001128 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 195103001129 putative active site pocket [active] 195103001130 dimerization interface [polypeptide binding]; other site 195103001131 putative catalytic residue [active] 195103001132 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 195103001133 active site clefts [active] 195103001134 zinc binding site [ion binding]; other site 195103001135 dimer interface [polypeptide binding]; other site 195103001136 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 195103001137 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 195103001138 heat shock protein 90; Provisional; Region: PRK05218 195103001139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103001140 ATP binding site [chemical binding]; other site 195103001141 Mg2+ binding site [ion binding]; other site 195103001142 G-X-G motif; other site 195103001143 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 195103001144 Predicted membrane protein [Function unknown]; Region: COG4640 195103001145 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 195103001146 Double zinc ribbon; Region: DZR; pfam12773 195103001147 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103001148 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103001149 DNA binding site [nucleotide binding] 195103001150 domain linker motif; other site 195103001151 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 195103001152 putative dimerization interface [polypeptide binding]; other site 195103001153 putative ligand binding site [chemical binding]; other site 195103001154 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 195103001155 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 195103001156 Ca binding site [ion binding]; other site 195103001157 active site 195103001158 catalytic site [active] 195103001159 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 195103001160 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 195103001161 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 195103001162 active site turn [active] 195103001163 phosphorylation site [posttranslational modification] 195103001164 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 195103001165 putative catalytic site [active] 195103001166 putative metal binding site [ion binding]; other site 195103001167 putative phosphate binding site [ion binding]; other site 195103001168 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 195103001169 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 195103001170 active site 195103001171 catalytic site [active] 195103001172 metal binding site [ion binding]; metal-binding site 195103001173 dimer interface [polypeptide binding]; other site 195103001174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103001175 putative substrate translocation pore; other site 195103001176 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195103001177 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 195103001178 Part of AAA domain; Region: AAA_19; pfam13245 195103001179 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 195103001180 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 195103001181 active site 195103001182 catalytic site [active] 195103001183 substrate binding site [chemical binding]; other site 195103001184 Family description; Region: UvrD_C_2; pfam13538 195103001185 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 195103001186 Uncharacterized conserved protein [Function unknown]; Region: COG3538 195103001187 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 195103001188 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 195103001189 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 195103001190 Catalytic site [active] 195103001191 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 195103001192 putative active site [active] 195103001193 putative metal binding site [ion binding]; other site 195103001194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 195103001195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103001196 Coenzyme A binding pocket [chemical binding]; other site 195103001197 YtxH-like protein; Region: YtxH; pfam12732 195103001198 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 195103001199 Domain of unknown function DUF21; Region: DUF21; pfam01595 195103001200 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 195103001201 Transporter associated domain; Region: CorC_HlyC; pfam03471 195103001202 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 195103001203 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 195103001204 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 195103001205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001206 dimer interface [polypeptide binding]; other site 195103001207 conserved gate region; other site 195103001208 putative PBP binding loops; other site 195103001209 ABC-ATPase subunit interface; other site 195103001210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001211 dimer interface [polypeptide binding]; other site 195103001212 conserved gate region; other site 195103001213 putative PBP binding loops; other site 195103001214 ABC-ATPase subunit interface; other site 195103001215 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 195103001216 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 195103001217 Walker A/P-loop; other site 195103001218 ATP binding site [chemical binding]; other site 195103001219 Q-loop/lid; other site 195103001220 ABC transporter signature motif; other site 195103001221 Walker B; other site 195103001222 D-loop; other site 195103001223 H-loop/switch region; other site 195103001224 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 195103001225 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 195103001226 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 195103001227 Predicted transcriptional regulators [Transcription]; Region: COG1725 195103001228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103001229 DNA-binding site [nucleotide binding]; DNA binding site 195103001230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 195103001231 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 195103001232 Walker A/P-loop; other site 195103001233 ATP binding site [chemical binding]; other site 195103001234 Q-loop/lid; other site 195103001235 ABC transporter signature motif; other site 195103001236 Walker B; other site 195103001237 D-loop; other site 195103001238 H-loop/switch region; other site 195103001239 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 195103001240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 195103001241 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 195103001242 dimer interface [polypeptide binding]; other site 195103001243 active site 195103001244 metal binding site [ion binding]; metal-binding site 195103001245 glutathione binding site [chemical binding]; other site 195103001246 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 195103001247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103001248 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103001249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103001250 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 195103001251 putative alcohol dehydrogenase; Provisional; Region: PRK09860 195103001252 dimer interface [polypeptide binding]; other site 195103001253 active site 195103001254 metal binding site [ion binding]; metal-binding site 195103001255 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 195103001256 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 195103001257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 195103001258 putative metal binding site [ion binding]; other site 195103001259 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103001260 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 195103001261 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 195103001262 DNA binding residues [nucleotide binding] 195103001263 drug binding residues [chemical binding]; other site 195103001264 dimer interface [polypeptide binding]; other site 195103001265 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 195103001266 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 195103001267 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195103001268 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103001269 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 195103001270 putative acyl-acceptor binding pocket; other site 195103001271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103001272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103001273 active site 195103001274 phosphorylation site [posttranslational modification] 195103001275 intermolecular recognition site; other site 195103001276 dimerization interface [polypeptide binding]; other site 195103001277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103001278 DNA binding site [nucleotide binding] 195103001279 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 195103001280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103001281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103001282 dimer interface [polypeptide binding]; other site 195103001283 phosphorylation site [posttranslational modification] 195103001284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103001285 ATP binding site [chemical binding]; other site 195103001286 Mg2+ binding site [ion binding]; other site 195103001287 G-X-G motif; other site 195103001288 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 195103001289 Chain length determinant protein; Region: Wzz; cl15801 195103001290 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 195103001291 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 195103001292 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195103001293 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 195103001294 Bacterial sugar transferase; Region: Bac_transf; pfam02397 195103001295 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 195103001296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 195103001297 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 195103001298 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 195103001299 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 195103001300 trimer interface [polypeptide binding]; other site 195103001301 active site 195103001302 substrate binding site [chemical binding]; other site 195103001303 CoA binding site [chemical binding]; other site 195103001304 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 195103001305 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 195103001306 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195103001307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103001308 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 195103001309 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 195103001310 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 195103001311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103001312 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195103001313 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195103001314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103001315 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195103001316 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 195103001317 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 195103001318 substrate binding site; other site 195103001319 tetramer interface; other site 195103001320 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 195103001321 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 195103001322 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 195103001323 NADP binding site [chemical binding]; other site 195103001324 active site 195103001325 putative substrate binding site [chemical binding]; other site 195103001326 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 195103001327 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 195103001328 NAD binding site [chemical binding]; other site 195103001329 substrate binding site [chemical binding]; other site 195103001330 homodimer interface [polypeptide binding]; other site 195103001331 active site 195103001332 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 195103001333 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 195103001334 active site 195103001335 tetramer interface; other site 195103001336 Helix-turn-helix domain; Region: HTH_16; pfam12645 195103001337 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 195103001338 UDP-glucose 4-epimerase; Region: PLN02240 195103001339 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 195103001340 NAD binding site [chemical binding]; other site 195103001341 homodimer interface [polypeptide binding]; other site 195103001342 active site 195103001343 substrate binding site [chemical binding]; other site 195103001344 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 195103001345 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 195103001346 active site 195103001347 tetramer interface; other site 195103001348 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 195103001349 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001350 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001351 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001352 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001353 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001354 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001355 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 195103001356 Melibiase; Region: Melibiase; pfam02065 195103001357 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 195103001358 active site 195103001359 catalytic site [active] 195103001360 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 195103001361 Catalytic site [active] 195103001362 alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090 195103001363 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 195103001364 alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090 195103001365 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 195103001366 metal ion-dependent adhesion site (MIDAS); other site 195103001367 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 195103001368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103001369 active site 195103001370 phosphorylation site [posttranslational modification] 195103001371 intermolecular recognition site; other site 195103001372 dimerization interface [polypeptide binding]; other site 195103001373 LytTr DNA-binding domain; Region: LytTR; pfam04397 195103001374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103001375 ATP binding site [chemical binding]; other site 195103001376 Mg2+ binding site [ion binding]; other site 195103001377 G-X-G motif; other site 195103001378 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 195103001379 active site 195103001380 catalytic triad [active] 195103001381 oxyanion hole [active] 195103001382 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 195103001383 active site 195103001384 phosphorylation site [posttranslational modification] 195103001385 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 195103001386 active site 195103001387 P-loop; other site 195103001388 phosphorylation site [posttranslational modification] 195103001389 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 195103001390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001391 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 195103001392 active site 195103001393 motif I; other site 195103001394 motif II; other site 195103001395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001396 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 195103001397 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 195103001398 Peptidase M16C associated; Region: M16C_assoc; pfam08367 195103001399 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103001400 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103001401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103001402 Walker A/P-loop; other site 195103001403 ATP binding site [chemical binding]; other site 195103001404 Q-loop/lid; other site 195103001405 ABC transporter signature motif; other site 195103001406 Walker B; other site 195103001407 D-loop; other site 195103001408 H-loop/switch region; other site 195103001409 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103001410 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103001411 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 195103001412 Walker A/P-loop; other site 195103001413 ATP binding site [chemical binding]; other site 195103001414 Q-loop/lid; other site 195103001415 ABC transporter signature motif; other site 195103001416 Walker B; other site 195103001417 D-loop; other site 195103001418 H-loop/switch region; other site 195103001419 Membrane transport protein; Region: Mem_trans; cl09117 195103001420 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 195103001421 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 195103001422 putative homodimer interface [polypeptide binding]; other site 195103001423 putative ligand binding site [chemical binding]; other site 195103001424 putative NAD binding site [chemical binding]; other site 195103001425 catalytic site [active] 195103001426 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 195103001427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103001428 ATP binding site [chemical binding]; other site 195103001429 Mg2+ binding site [ion binding]; other site 195103001430 G-X-G motif; other site 195103001431 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 195103001432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103001433 active site 195103001434 phosphorylation site [posttranslational modification] 195103001435 intermolecular recognition site; other site 195103001436 dimerization interface [polypeptide binding]; other site 195103001437 Predicted membrane protein [Function unknown]; Region: COG1971 195103001438 Domain of unknown function DUF; Region: DUF204; pfam02659 195103001439 Domain of unknown function DUF; Region: DUF204; pfam02659 195103001440 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 195103001441 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 195103001442 active site 195103001443 NAD binding site [chemical binding]; other site 195103001444 metal binding site [ion binding]; metal-binding site 195103001445 TrkA-C domain; Region: TrkA_C; pfam02080 195103001446 Transcriptional regulators [Transcription]; Region: MarR; COG1846 195103001447 MarR family; Region: MarR_2; pfam12802 195103001448 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 195103001449 Domain of unknown function DUF20; Region: UPF0118; pfam01594 195103001450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103001451 putative substrate translocation pore; other site 195103001452 POT family; Region: PTR2; cl17359 195103001453 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 195103001454 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 195103001455 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 195103001456 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 195103001457 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 195103001458 homodimer interface [polypeptide binding]; other site 195103001459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103001460 catalytic residue [active] 195103001461 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 195103001462 spermidine synthase; Provisional; Region: PRK00811 195103001463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103001464 S-adenosylmethionine binding site [chemical binding]; other site 195103001465 agmatinase; Region: agmatinase; TIGR01230 195103001466 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 195103001467 putative active site [active] 195103001468 Mn binding site [ion binding]; other site 195103001469 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 195103001470 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103001471 sugar binding site [chemical binding]; other site 195103001472 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 195103001473 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 195103001474 Asp-box motif; other site 195103001475 catalytic site [active] 195103001476 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 195103001477 dockerin binding interface; other site 195103001478 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103001479 Interdomain contacts; other site 195103001480 Cytokine receptor motif; other site 195103001481 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 195103001482 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 195103001483 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 195103001484 metal-binding site [ion binding] 195103001485 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 195103001486 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 195103001487 metal-binding site [ion binding] 195103001488 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 195103001489 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 195103001490 metal-binding site [ion binding] 195103001491 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195103001492 Soluble P-type ATPase [General function prediction only]; Region: COG4087 195103001493 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 195103001494 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 195103001495 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 195103001496 Walker A/P-loop; other site 195103001497 ATP binding site [chemical binding]; other site 195103001498 Q-loop/lid; other site 195103001499 ABC transporter signature motif; other site 195103001500 Walker B; other site 195103001501 D-loop; other site 195103001502 H-loop/switch region; other site 195103001503 FOG: CBS domain [General function prediction only]; Region: COG0517 195103001504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 195103001505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001506 dimer interface [polypeptide binding]; other site 195103001507 conserved gate region; other site 195103001508 putative PBP binding loops; other site 195103001509 ABC-ATPase subunit interface; other site 195103001510 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 195103001511 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 195103001512 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 195103001513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103001514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195103001515 DNA binding residues [nucleotide binding] 195103001516 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 195103001517 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 195103001518 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 195103001519 active site turn [active] 195103001520 phosphorylation site [posttranslational modification] 195103001521 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 195103001522 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 195103001523 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 195103001524 Ca binding site [ion binding]; other site 195103001525 active site 195103001526 catalytic site [active] 195103001527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103001528 DNA-binding site [nucleotide binding]; DNA binding site 195103001529 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 195103001530 UTRA domain; Region: UTRA; pfam07702 195103001531 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 195103001532 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 195103001533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 195103001534 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 195103001535 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 195103001536 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 195103001537 amidase catalytic site [active] 195103001538 Zn binding residues [ion binding]; other site 195103001539 substrate binding site [chemical binding]; other site 195103001540 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 195103001541 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 195103001542 catalytic motif [active] 195103001543 Zn binding site [ion binding]; other site 195103001544 RibD C-terminal domain; Region: RibD_C; cl17279 195103001545 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 195103001546 Lumazine binding domain; Region: Lum_binding; pfam00677 195103001547 Lumazine binding domain; Region: Lum_binding; pfam00677 195103001548 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 195103001549 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 195103001550 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 195103001551 dimerization interface [polypeptide binding]; other site 195103001552 active site 195103001553 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 195103001554 homopentamer interface [polypeptide binding]; other site 195103001555 active site 195103001556 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001557 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 195103001558 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001559 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 195103001560 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001561 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 195103001562 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 195103001563 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 195103001564 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 195103001565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103001566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103001567 dimerization interface [polypeptide binding]; other site 195103001568 Histidine kinase; Region: His_kinase; pfam06580 195103001569 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 195103001570 ATP binding site [chemical binding]; other site 195103001571 Mg2+ binding site [ion binding]; other site 195103001572 G-X-G motif; other site 195103001573 Response regulator receiver domain; Region: Response_reg; pfam00072 195103001574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103001575 active site 195103001576 phosphorylation site [posttranslational modification] 195103001577 intermolecular recognition site; other site 195103001578 dimerization interface [polypeptide binding]; other site 195103001579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103001580 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103001581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103001582 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 195103001583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 195103001584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 195103001585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001586 dimer interface [polypeptide binding]; other site 195103001587 conserved gate region; other site 195103001588 putative PBP binding loops; other site 195103001589 ABC-ATPase subunit interface; other site 195103001590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 195103001591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001592 dimer interface [polypeptide binding]; other site 195103001593 conserved gate region; other site 195103001594 putative PBP binding loops; other site 195103001595 ABC-ATPase subunit interface; other site 195103001596 Uncharacterized conserved protein [Function unknown]; Region: COG0398 195103001597 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103001598 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 195103001599 Cysteine-rich domain; Region: CCG; pfam02754 195103001600 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 195103001601 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 195103001602 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 195103001603 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 195103001604 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 195103001605 active site 195103001606 phosphorylation site [posttranslational modification] 195103001607 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 195103001608 active site 195103001609 P-loop; other site 195103001610 phosphorylation site [posttranslational modification] 195103001611 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 195103001612 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 195103001613 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 195103001614 putative substrate binding site [chemical binding]; other site 195103001615 putative ATP binding site [chemical binding]; other site 195103001616 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 195103001617 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 195103001618 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 195103001619 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 195103001620 Domain of unknown function DUF20; Region: UPF0118; pfam01594 195103001621 Isochorismatase family; Region: Isochorismatase; pfam00857 195103001622 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 195103001623 catalytic triad [active] 195103001624 conserved cis-peptide bond; other site 195103001625 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 195103001626 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 195103001627 putative Cl- selectivity filter; other site 195103001628 putative pore gating glutamate residue; other site 195103001629 glutaminase A; Region: Gln_ase; TIGR03814 195103001630 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 195103001631 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 195103001632 MgtC family; Region: MgtC; pfam02308 195103001633 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 195103001634 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 195103001635 putative NADH binding site [chemical binding]; other site 195103001636 putative active site [active] 195103001637 nudix motif; other site 195103001638 putative metal binding site [ion binding]; other site 195103001639 diaminopimelate decarboxylase; Region: lysA; TIGR01048 195103001640 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 195103001641 active site 195103001642 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195103001643 substrate binding site [chemical binding]; other site 195103001644 catalytic residues [active] 195103001645 dimer interface [polypeptide binding]; other site 195103001646 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 195103001647 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 195103001648 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 195103001649 Catalytic site [active] 195103001650 FtsH Extracellular; Region: FtsH_ext; pfam06480 195103001651 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 195103001652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103001653 Walker A motif; other site 195103001654 ATP binding site [chemical binding]; other site 195103001655 Walker B motif; other site 195103001656 arginine finger; other site 195103001657 Peptidase family M41; Region: Peptidase_M41; pfam01434 195103001658 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 195103001659 Part of AAA domain; Region: AAA_19; pfam13245 195103001660 Family description; Region: UvrD_C_2; pfam13538 195103001661 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195103001662 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 195103001663 substrate binding pocket [chemical binding]; other site 195103001664 membrane-bound complex binding site; other site 195103001665 hinge residues; other site 195103001666 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 195103001667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001668 dimer interface [polypeptide binding]; other site 195103001669 conserved gate region; other site 195103001670 putative PBP binding loops; other site 195103001671 ABC-ATPase subunit interface; other site 195103001672 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 195103001673 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 195103001674 Walker A/P-loop; other site 195103001675 ATP binding site [chemical binding]; other site 195103001676 Q-loop/lid; other site 195103001677 ABC transporter signature motif; other site 195103001678 Walker B; other site 195103001679 D-loop; other site 195103001680 H-loop/switch region; other site 195103001681 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 195103001682 Sulfatase; Region: Sulfatase; cl17466 195103001683 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 195103001684 Sulfatase; Region: Sulfatase; cl17466 195103001685 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 195103001686 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 195103001687 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 195103001688 amidase catalytic site [active] 195103001689 Zn binding residues [ion binding]; other site 195103001690 substrate binding site [chemical binding]; other site 195103001691 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103001692 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103001693 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103001694 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103001695 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 195103001696 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 195103001697 active site 195103001698 metal binding site [ion binding]; metal-binding site 195103001699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001700 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 195103001701 active site 195103001702 motif I; other site 195103001703 motif II; other site 195103001704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001705 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195103001706 MMPL family; Region: MMPL; pfam03176 195103001707 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 195103001708 Carbon starvation protein CstA; Region: CstA; pfam02554 195103001709 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 195103001710 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 195103001711 G1 box; other site 195103001712 putative GEF interaction site [polypeptide binding]; other site 195103001713 GTP/Mg2+ binding site [chemical binding]; other site 195103001714 Switch I region; other site 195103001715 G2 box; other site 195103001716 G3 box; other site 195103001717 Switch II region; other site 195103001718 G4 box; other site 195103001719 G5 box; other site 195103001720 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 195103001721 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 195103001722 AAA domain; Region: AAA_28; pfam13521 195103001723 sugar phosphate phosphatase; Provisional; Region: PRK10513 195103001724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001725 active site 195103001726 motif I; other site 195103001727 motif II; other site 195103001728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103001729 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 195103001730 Bacterial sugar transferase; Region: Bac_transf; pfam02397 195103001731 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195103001732 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 195103001733 active site 195103001734 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 195103001735 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 195103001736 substrate binding site; other site 195103001737 tetramer interface; other site 195103001738 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 195103001739 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 195103001740 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 195103001741 NADP binding site [chemical binding]; other site 195103001742 active site 195103001743 putative substrate binding site [chemical binding]; other site 195103001744 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 195103001745 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 195103001746 NAD binding site [chemical binding]; other site 195103001747 substrate binding site [chemical binding]; other site 195103001748 homodimer interface [polypeptide binding]; other site 195103001749 active site 195103001750 O-Antigen ligase; Region: Wzy_C; pfam04932 195103001751 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 195103001752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 195103001753 active site 195103001754 LicD family; Region: LicD; pfam04991 195103001755 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 195103001756 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 195103001757 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 195103001758 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001759 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 195103001760 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001761 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 195103001762 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 195103001763 active site 195103001764 Zn binding site [ion binding]; other site 195103001765 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 195103001766 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 195103001767 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 195103001768 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 195103001770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 195103001771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 195103001772 active site 195103001773 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 195103001774 active site 195103001775 ATP binding site [chemical binding]; other site 195103001776 Phosphotransferase enzyme family; Region: APH; pfam01636 195103001777 substrate binding site [chemical binding]; other site 195103001778 dimer interface [polypeptide binding]; other site 195103001779 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 195103001780 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 195103001781 EamA-like transporter family; Region: EamA; cl17759 195103001782 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 195103001783 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 195103001784 active site 195103001785 metal-binding site 195103001786 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001787 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001788 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 195103001789 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 195103001790 Transcriptional regulator [Transcription]; Region: LytR; COG1316 195103001791 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 195103001792 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 195103001793 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 195103001794 active site 195103001795 HIGH motif; other site 195103001796 dimer interface [polypeptide binding]; other site 195103001797 KMSKS motif; other site 195103001798 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 195103001799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103001800 FeS/SAM binding site; other site 195103001801 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 195103001802 PBP superfamily domain; Region: PBP_like_2; cl17296 195103001803 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 195103001804 PBP superfamily domain; Region: PBP_like_2; cl17296 195103001805 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 195103001806 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 195103001807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001808 dimer interface [polypeptide binding]; other site 195103001809 conserved gate region; other site 195103001810 putative PBP binding loops; other site 195103001811 ABC-ATPase subunit interface; other site 195103001812 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 195103001813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103001814 dimer interface [polypeptide binding]; other site 195103001815 conserved gate region; other site 195103001816 putative PBP binding loops; other site 195103001817 ABC-ATPase subunit interface; other site 195103001818 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 195103001819 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 195103001820 Walker A/P-loop; other site 195103001821 ATP binding site [chemical binding]; other site 195103001822 Q-loop/lid; other site 195103001823 ABC transporter signature motif; other site 195103001824 Walker B; other site 195103001825 D-loop; other site 195103001826 H-loop/switch region; other site 195103001827 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 195103001828 PhoU domain; Region: PhoU; pfam01895 195103001829 PhoU domain; Region: PhoU; pfam01895 195103001830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103001831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103001832 active site 195103001833 phosphorylation site [posttranslational modification] 195103001834 intermolecular recognition site; other site 195103001835 dimerization interface [polypeptide binding]; other site 195103001836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103001837 DNA binding site [nucleotide binding] 195103001838 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 195103001839 flavodoxin; Provisional; Region: PRK05568 195103001840 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 195103001841 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 195103001842 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 195103001843 active site 195103001844 HIGH motif; other site 195103001845 nucleotide binding site [chemical binding]; other site 195103001846 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 195103001847 KMSKS motif; other site 195103001848 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 195103001849 Probable zinc-binding domain; Region: zf-trcl; pfam13451 195103001850 Spore germination protein; Region: Spore_permease; cl17796 195103001851 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 195103001852 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 195103001853 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 195103001854 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 195103001855 Divergent AAA domain; Region: AAA_4; pfam04326 195103001856 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 195103001857 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 195103001858 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 195103001859 active site 195103001860 HIGH motif; other site 195103001861 dimer interface [polypeptide binding]; other site 195103001862 KMSKS motif; other site 195103001863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103001864 RNA binding surface [nucleotide binding]; other site 195103001865 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 195103001866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 195103001867 putative active site [active] 195103001868 putative metal binding site [ion binding]; other site 195103001869 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 195103001870 synthetase active site [active] 195103001871 NTP binding site [chemical binding]; other site 195103001872 metal binding site [ion binding]; metal-binding site 195103001873 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 195103001874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103001875 Walker A motif; other site 195103001876 ATP binding site [chemical binding]; other site 195103001877 Walker B motif; other site 195103001878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 195103001879 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 195103001880 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 195103001881 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 195103001882 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 195103001883 NodB motif; other site 195103001884 putative active site [active] 195103001885 putative catalytic site [active] 195103001886 putative Zn binding site [ion binding]; other site 195103001887 glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040 195103001888 Pyruvate formate lyase; Region: PFL; pfam02901 195103001889 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 195103001890 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 195103001891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103001892 FeS/SAM binding site; other site 195103001893 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 195103001894 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 195103001895 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 195103001896 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 195103001897 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 195103001898 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 195103001899 active site 195103001900 phosphorylation site [posttranslational modification] 195103001901 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 195103001902 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 195103001903 active site 195103001904 P-loop; other site 195103001905 phosphorylation site [posttranslational modification] 195103001906 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 195103001907 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 195103001908 intersubunit interface [polypeptide binding]; other site 195103001909 active site 195103001910 Zn2+ binding site [ion binding]; other site 195103001911 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 195103001912 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 195103001913 AP (apurinic/apyrimidinic) site pocket; other site 195103001914 DNA interaction; other site 195103001915 Metal-binding active site; metal-binding site 195103001916 Tetratricopeptide repeat; Region: TPR_12; pfam13424 195103001917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103001918 binding surface 195103001919 TPR motif; other site 195103001920 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 195103001921 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 195103001922 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103001923 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 195103001924 HesB-like selenoprotein; Region: HesB_rel_seleno; TIGR01911 195103001925 Right handed beta helix region; Region: Beta_helix; pfam13229 195103001926 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 195103001927 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 195103001928 HIGH motif; other site 195103001929 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 195103001930 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 195103001931 active site 195103001932 KMSKS motif; other site 195103001933 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 195103001934 tRNA binding surface [nucleotide binding]; other site 195103001935 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 195103001936 Cl- selectivity filter; other site 195103001937 Cl- binding residues [ion binding]; other site 195103001938 pore gating glutamate residue; other site 195103001939 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 195103001940 nudix motif; other site 195103001941 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 195103001942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103001943 dimerization interface [polypeptide binding]; other site 195103001944 putative DNA binding site [nucleotide binding]; other site 195103001945 putative Zn2+ binding site [ion binding]; other site 195103001946 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 195103001947 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 195103001948 Nuclease-related domain; Region: NERD; pfam08378 195103001949 HRDC domain; Region: HRDC; pfam00570 195103001950 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 195103001951 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 195103001952 trimer interface [polypeptide binding]; other site 195103001953 active site 195103001954 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 195103001955 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 195103001956 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 195103001957 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 195103001958 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 195103001959 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 195103001960 dimerization interface [polypeptide binding]; other site 195103001961 ATP binding site [chemical binding]; other site 195103001962 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 195103001963 dimerization interface [polypeptide binding]; other site 195103001964 ATP binding site [chemical binding]; other site 195103001965 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 195103001966 putative active site [active] 195103001967 catalytic triad [active] 195103001968 AIR carboxylase; Region: AIRC; pfam00731 195103001969 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 195103001970 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 195103001971 ATP binding site [chemical binding]; other site 195103001972 active site 195103001973 substrate binding site [chemical binding]; other site 195103001974 amidophosphoribosyltransferase; Provisional; Region: PRK05793 195103001975 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 195103001976 active site 195103001977 tetramer interface [polypeptide binding]; other site 195103001978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103001979 active site 195103001980 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 195103001981 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 195103001982 dimerization interface [polypeptide binding]; other site 195103001983 putative ATP binding site [chemical binding]; other site 195103001984 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 195103001985 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 195103001986 active site 195103001987 substrate binding site [chemical binding]; other site 195103001988 cosubstrate binding site; other site 195103001989 catalytic site [active] 195103001990 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 195103001991 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 195103001992 purine monophosphate binding site [chemical binding]; other site 195103001993 dimer interface [polypeptide binding]; other site 195103001994 putative catalytic residues [active] 195103001995 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 195103001996 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 195103001997 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 195103001998 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 195103001999 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 195103002000 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 195103002001 hypothetical protein; Provisional; Region: PRK11770 195103002002 Domain of unknown function (DUF307); Region: DUF307; pfam03733 195103002003 Domain of unknown function (DUF307); Region: DUF307; pfam03733 195103002004 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103002005 Rubredoxin; Region: Rubredoxin; pfam00301 195103002006 iron binding site [ion binding]; other site 195103002007 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 195103002008 Rubrerythrin [Energy production and conversion]; Region: COG1592 195103002009 diiron binding motif [ion binding]; other site 195103002010 argininosuccinate lyase; Provisional; Region: PRK00855 195103002011 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 195103002012 active sites [active] 195103002013 tetramer interface [polypeptide binding]; other site 195103002014 argininosuccinate synthase; Provisional; Region: PRK13820 195103002015 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 195103002016 ANP binding site [chemical binding]; other site 195103002017 Substrate Binding Site II [chemical binding]; other site 195103002018 Substrate Binding Site I [chemical binding]; other site 195103002019 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 195103002020 active site 195103002021 intersubunit interactions; other site 195103002022 catalytic residue [active] 195103002023 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 195103002024 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 195103002025 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 195103002026 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103002027 Interdomain contacts; other site 195103002028 Cytokine receptor motif; other site 195103002029 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 195103002030 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 195103002031 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 195103002032 active site 195103002033 dimer interface [polypeptide binding]; other site 195103002034 metal binding site [ion binding]; metal-binding site 195103002035 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 195103002036 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 195103002037 hinge; other site 195103002038 active site 195103002039 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 195103002040 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 195103002041 Tetramer interface [polypeptide binding]; other site 195103002042 active site 195103002043 FMN-binding site [chemical binding]; other site 195103002044 Chorismate mutase type II; Region: CM_2; pfam01817 195103002045 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 195103002046 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 195103002047 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 195103002048 shikimate binding site; other site 195103002049 NAD(P) binding site [chemical binding]; other site 195103002050 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 195103002051 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 195103002052 ADP binding site [chemical binding]; other site 195103002053 magnesium binding site [ion binding]; other site 195103002054 putative shikimate binding site; other site 195103002055 Dehydroquinase class II; Region: DHquinase_II; pfam01220 195103002056 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 195103002057 trimer interface [polypeptide binding]; other site 195103002058 active site 195103002059 dimer interface [polypeptide binding]; other site 195103002060 Predicted transcriptional regulators [Transcription]; Region: COG1733 195103002061 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 195103002062 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 195103002063 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 195103002064 active site 195103002065 FMN binding site [chemical binding]; other site 195103002066 substrate binding site [chemical binding]; other site 195103002067 putative catalytic residue [active] 195103002068 Predicted transcriptional regulators [Transcription]; Region: COG1695 195103002069 Transcriptional regulator PadR-like family; Region: PadR; cl17335 195103002070 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 195103002071 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 195103002072 Walker A/P-loop; other site 195103002073 ATP binding site [chemical binding]; other site 195103002074 Q-loop/lid; other site 195103002075 ABC transporter signature motif; other site 195103002076 Walker B; other site 195103002077 D-loop; other site 195103002078 H-loop/switch region; other site 195103002079 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 195103002080 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 195103002081 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 195103002082 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 195103002083 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 195103002084 active site 195103002085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 195103002086 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 195103002087 AsnC family; Region: AsnC_trans_reg; pfam01037 195103002088 hypothetical protein; Validated; Region: PRK07682 195103002089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103002090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103002091 homodimer interface [polypeptide binding]; other site 195103002092 catalytic residue [active] 195103002093 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; smart00770 195103002094 Zn binding site [ion binding]; other site 195103002095 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 195103002096 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 195103002097 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195103002098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 195103002099 Coenzyme A binding pocket [chemical binding]; other site 195103002100 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 195103002101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103002102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195103002103 DNA binding residues [nucleotide binding] 195103002104 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 195103002105 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 195103002106 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 195103002107 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195103002108 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 195103002109 active site 195103002110 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 195103002111 Domain of unknown function DUF20; Region: UPF0118; pfam01594 195103002112 zinc transporter ZupT; Provisional; Region: PRK04201 195103002113 ZIP Zinc transporter; Region: Zip; pfam02535 195103002114 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 195103002115 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 195103002116 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 195103002117 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 195103002118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103002119 active site 195103002120 motif I; other site 195103002121 motif II; other site 195103002122 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195103002123 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 195103002124 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 195103002125 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 195103002126 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 195103002127 catalytic site [active] 195103002128 BNR repeat-like domain; Region: BNR_2; pfam13088 195103002129 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 195103002130 Asp-box motif; other site 195103002131 Asp-box motif; other site 195103002132 catalytic site [active] 195103002133 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 195103002134 Galactose oxidase, central domain; Region: Kelch_3; cl02701 195103002135 short chain dehydrogenase; Validated; Region: PRK06182 195103002136 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 195103002137 NADP binding site [chemical binding]; other site 195103002138 active site 195103002139 steroid binding site; other site 195103002140 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 195103002141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002142 Coenzyme A binding pocket [chemical binding]; other site 195103002143 MYM-type Zinc finger with FCS sequence motif; Region: zf-FCS; pfam06467 195103002144 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 195103002145 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 195103002146 Ligand Binding Site [chemical binding]; other site 195103002147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 195103002148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 195103002149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 195103002150 dimerization interface [polypeptide binding]; other site 195103002151 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 195103002152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195103002153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195103002154 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 195103002155 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 195103002156 active site residue [active] 195103002157 Sulphur transport; Region: Sulf_transp; pfam04143 195103002158 Amino acid permease; Region: AA_permease_2; pfam13520 195103002159 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 195103002160 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 195103002161 nucleotide binding site [chemical binding]; other site 195103002162 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 195103002163 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 195103002164 inhibitor binding site; inhibition site 195103002165 catalytic Zn binding site [ion binding]; other site 195103002166 structural Zn binding site [ion binding]; other site 195103002167 NADP binding site [chemical binding]; other site 195103002168 tetramer interface [polypeptide binding]; other site 195103002169 MFS/sugar transport protein; Region: MFS_2; pfam13347 195103002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103002171 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 195103002172 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 195103002173 putative substrate binding site [chemical binding]; other site 195103002174 putative ATP binding site [chemical binding]; other site 195103002175 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 195103002176 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 195103002177 catalytic residues [active] 195103002178 Predicted transcriptional regulators [Transcription]; Region: COG1733 195103002179 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 195103002180 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 195103002181 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 195103002182 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 195103002183 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 195103002184 catalytic residues [active] 195103002185 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 195103002186 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 195103002187 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 195103002188 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 195103002189 Carbon starvation protein CstA; Region: CstA; pfam02554 195103002190 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 195103002191 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 195103002192 Carbon starvation protein CstA; Region: CstA; pfam02554 195103002193 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 195103002194 YmaF family; Region: YmaF; pfam12788 195103002195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 195103002196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 195103002197 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 195103002198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195103002199 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195103002200 Walker A/P-loop; other site 195103002201 ATP binding site [chemical binding]; other site 195103002202 Q-loop/lid; other site 195103002203 ABC transporter signature motif; other site 195103002204 Walker B; other site 195103002205 D-loop; other site 195103002206 H-loop/switch region; other site 195103002207 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 195103002208 FtsX-like permease family; Region: FtsX; pfam02687 195103002209 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 195103002210 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 195103002211 FtsX-like permease family; Region: FtsX; pfam02687 195103002212 Enterocin A Immunity; Region: EntA_Immun; pfam08951 195103002213 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 195103002214 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 195103002215 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 195103002216 putative active site [active] 195103002217 catalytic site [active] 195103002218 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 195103002219 putative active site [active] 195103002220 catalytic site [active] 195103002221 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 195103002222 putative NADH binding site [chemical binding]; other site 195103002223 putative active site [active] 195103002224 nudix motif; other site 195103002225 putative metal binding site [ion binding]; other site 195103002226 cytosine deaminase; Provisional; Region: PRK09230 195103002227 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 195103002228 active site 195103002229 Creatinine amidohydrolase; Region: Creatininase; pfam02633 195103002230 EamA-like transporter family; Region: EamA; pfam00892 195103002231 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 195103002232 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 195103002233 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 195103002234 active site 195103002235 catalytic residues [active] 195103002236 metal binding site [ion binding]; metal-binding site 195103002237 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 195103002238 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 195103002239 dUMP phosphatase; Provisional; Region: PRK09449 195103002240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103002241 motif II; other site 195103002242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002243 Coenzyme A binding pocket [chemical binding]; other site 195103002244 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 195103002245 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 195103002246 DNA binding residues [nucleotide binding] 195103002247 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 195103002248 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 195103002249 Probable zinc-binding domain; Region: zf-trcl; pfam13451 195103002250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103002251 MFS/sugar transport protein; Region: MFS_2; pfam13347 195103002252 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 195103002253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103002254 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103002255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103002256 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 195103002257 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 195103002258 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 195103002259 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 195103002260 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 195103002261 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 195103002262 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 195103002263 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 195103002264 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 195103002265 iron-sulfur cluster [ion binding]; other site 195103002266 [2Fe-2S] cluster binding site [ion binding]; other site 195103002267 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 195103002268 fructuronate transporter; Provisional; Region: PRK10034; cl15264 195103002269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 195103002270 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 195103002271 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 195103002272 Dimer interface [polypeptide binding]; other site 195103002273 anticodon binding site; other site 195103002274 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 195103002275 homodimer interface [polypeptide binding]; other site 195103002276 motif 1; other site 195103002277 motif 2; other site 195103002278 active site 195103002279 motif 3; other site 195103002280 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 195103002281 Cna protein B-type domain; Region: Cna_B; pfam05738 195103002282 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 195103002283 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 195103002284 active site 195103002285 catalytic site [active] 195103002286 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 195103002287 active site 195103002288 catalytic site [active] 195103002289 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 195103002290 metal ion-dependent adhesion site (MIDAS); other site 195103002291 Cna protein B-type domain; Region: Cna_B; pfam05738 195103002292 Cna protein B-type domain; Region: Cna_B; pfam05738 195103002293 Cna protein B-type domain; Region: Cna_B; pfam05738 195103002294 Mga helix-turn-helix domain; Region: Mga; pfam05043 195103002295 Family of unknown function (DUF438); Region: DUF438; pfam04282 195103002296 Hemerythrin-like domain; Region: Hr-like; cd12108 195103002297 Fe binding site [ion binding]; other site 195103002298 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 195103002299 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 195103002300 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 195103002301 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 195103002302 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195103002303 ligand binding site [chemical binding]; other site 195103002304 flexible hinge region; other site 195103002305 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 195103002306 putative switch regulator; other site 195103002307 non-specific DNA interactions [nucleotide binding]; other site 195103002308 DNA binding site [nucleotide binding] 195103002309 sequence specific DNA binding site [nucleotide binding]; other site 195103002310 putative cAMP binding site [chemical binding]; other site 195103002311 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 195103002312 Rubredoxin; Region: Rubredoxin; pfam00301 195103002313 iron binding site [ion binding]; other site 195103002314 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 195103002315 FAD binding pocket [chemical binding]; other site 195103002316 FAD binding motif [chemical binding]; other site 195103002317 phosphate binding motif [ion binding]; other site 195103002318 beta-alpha-beta structure motif; other site 195103002319 NAD binding pocket [chemical binding]; other site 195103002320 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 195103002321 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195103002322 ligand binding site [chemical binding]; other site 195103002323 flexible hinge region; other site 195103002324 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 195103002325 putative switch regulator; other site 195103002326 non-specific DNA interactions [nucleotide binding]; other site 195103002327 DNA binding site [nucleotide binding] 195103002328 sequence specific DNA binding site [nucleotide binding]; other site 195103002329 putative cAMP binding site [chemical binding]; other site 195103002330 Rubredoxin; Region: Rubredoxin; pfam00301 195103002331 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 195103002332 iron binding site [ion binding]; other site 195103002333 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 195103002334 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 195103002335 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 195103002336 peroxiredoxin; Region: AhpC; TIGR03137 195103002337 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 195103002338 dimer interface [polypeptide binding]; other site 195103002339 decamer (pentamer of dimers) interface [polypeptide binding]; other site 195103002340 catalytic triad [active] 195103002341 peroxidatic and resolving cysteines [active] 195103002342 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 195103002343 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 195103002344 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 195103002345 catalytic residue [active] 195103002346 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 195103002347 catalytic residues [active] 195103002348 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 195103002349 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 195103002350 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 195103002351 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 195103002352 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 195103002353 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 195103002354 MarR family; Region: MarR_2; pfam12802 195103002355 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 195103002356 MarR family; Region: MarR_2; pfam12802 195103002357 MarR family; Region: MarR_2; cl17246 195103002358 Pirin-related protein [General function prediction only]; Region: COG1741 195103002359 Pirin; Region: Pirin; pfam02678 195103002360 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 195103002361 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 195103002362 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 195103002363 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 195103002364 nudix motif; other site 195103002365 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 195103002366 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 195103002367 active site 195103002368 Protein of unknown function DUF45; Region: DUF45; pfam01863 195103002369 PAS fold; Region: PAS_4; pfam08448 195103002370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 195103002371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195103002372 metal binding site [ion binding]; metal-binding site 195103002373 active site 195103002374 I-site; other site 195103002375 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 195103002376 histidinol-phosphatase; Reviewed; Region: PRK08123 195103002377 active site 195103002378 dimer interface [polypeptide binding]; other site 195103002379 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 195103002380 homodimer interface [polypeptide binding]; other site 195103002381 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 195103002382 active site 195103002383 homodimer interface [polypeptide binding]; other site 195103002384 catalytic site [active] 195103002385 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 195103002386 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 195103002387 Uncharacterized conserved protein [Function unknown]; Region: COG1434 195103002388 putative active site [active] 195103002389 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 195103002390 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 195103002391 putative ligand binding residues [chemical binding]; other site 195103002392 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 195103002393 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195103002394 ABC-ATPase subunit interface; other site 195103002395 dimer interface [polypeptide binding]; other site 195103002396 putative PBP binding regions; other site 195103002397 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 195103002398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195103002399 ABC-ATPase subunit interface; other site 195103002400 dimer interface [polypeptide binding]; other site 195103002401 putative PBP binding regions; other site 195103002402 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 195103002403 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 195103002404 Walker A/P-loop; other site 195103002405 ATP binding site [chemical binding]; other site 195103002406 Q-loop/lid; other site 195103002407 ABC transporter signature motif; other site 195103002408 Walker B; other site 195103002409 D-loop; other site 195103002410 H-loop/switch region; other site 195103002411 putative acetyltransferase YhhY; Provisional; Region: PRK10140 195103002412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002413 Coenzyme A binding pocket [chemical binding]; other site 195103002414 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 195103002415 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 195103002416 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 195103002417 putative active site [active] 195103002418 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002419 sugar binding site [chemical binding]; other site 195103002420 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103002421 Interdomain contacts; other site 195103002422 Cytokine receptor motif; other site 195103002423 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 195103002424 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 195103002425 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195103002426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103002427 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 195103002428 active site 195103002429 motif I; other site 195103002430 motif II; other site 195103002431 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 195103002432 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 195103002433 active pocket/dimerization site; other site 195103002434 active site 195103002435 phosphorylation site [posttranslational modification] 195103002436 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 195103002437 active site 195103002438 phosphorylation site [posttranslational modification] 195103002439 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 195103002440 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 195103002441 Domain of unknown function (DUF956); Region: DUF956; pfam06115 195103002442 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 195103002443 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 195103002444 NodB motif; other site 195103002445 active site 195103002446 catalytic site [active] 195103002447 Zn binding site [ion binding]; other site 195103002448 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 195103002449 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 195103002450 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 195103002451 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 195103002452 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 195103002453 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 195103002454 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 195103002455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103002456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103002457 Walker A/P-loop; other site 195103002458 ATP binding site [chemical binding]; other site 195103002459 Q-loop/lid; other site 195103002460 ABC transporter signature motif; other site 195103002461 Walker B; other site 195103002462 D-loop; other site 195103002463 H-loop/switch region; other site 195103002464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103002465 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195103002466 Walker A/P-loop; other site 195103002467 ATP binding site [chemical binding]; other site 195103002468 Q-loop/lid; other site 195103002469 ABC transporter signature motif; other site 195103002470 Walker B; other site 195103002471 D-loop; other site 195103002472 H-loop/switch region; other site 195103002473 Uncharacterized conserved protein [Function unknown]; Region: COG3402 195103002474 Bacterial PH domain; Region: DUF304; pfam03703 195103002475 Bacterial PH domain; Region: DUF304; pfam03703 195103002476 Bacterial PH domain; Region: DUF304; pfam03703 195103002477 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103002478 dimerization interface [polypeptide binding]; other site 195103002479 putative DNA binding site [nucleotide binding]; other site 195103002480 putative Zn2+ binding site [ion binding]; other site 195103002481 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 195103002482 Low molecular weight phosphatase family; Region: LMWPc; cd00115 195103002483 active site 195103002484 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103002485 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 195103002486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103002487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103002488 active site 195103002489 phosphorylation site [posttranslational modification] 195103002490 intermolecular recognition site; other site 195103002491 dimerization interface [polypeptide binding]; other site 195103002492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103002493 DNA binding site [nucleotide binding] 195103002494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103002495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103002496 ATP binding site [chemical binding]; other site 195103002497 G-X-G motif; other site 195103002498 Fic family protein [Function unknown]; Region: COG3177 195103002499 Fic/DOC family; Region: Fic; pfam02661 195103002500 T5orf172 domain; Region: T5orf172; cl17462 195103002501 clostripain; Region: clostrip; TIGR02806 195103002502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195103002503 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195103002504 Walker A/P-loop; other site 195103002505 ATP binding site [chemical binding]; other site 195103002506 Q-loop/lid; other site 195103002507 ABC transporter signature motif; other site 195103002508 Walker B; other site 195103002509 D-loop; other site 195103002510 H-loop/switch region; other site 195103002511 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 195103002512 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 195103002513 putative active site [active] 195103002514 putative catalytic site [active] 195103002515 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 195103002516 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 195103002517 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103002518 catalytic residue [active] 195103002519 Rubrerythrin [Energy production and conversion]; Region: COG1592 195103002520 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 195103002521 binuclear metal center [ion binding]; other site 195103002522 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103002523 iron binding site [ion binding]; other site 195103002524 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 195103002525 active site 195103002526 catalytic site [active] 195103002527 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 195103002528 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 195103002529 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 195103002530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002531 Coenzyme A binding pocket [chemical binding]; other site 195103002532 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 195103002533 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 195103002534 dimer interface [polypeptide binding]; other site 195103002535 active site 195103002536 metal binding site [ion binding]; metal-binding site 195103002537 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 195103002538 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 195103002539 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 195103002540 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 195103002541 fructuronate transporter; Provisional; Region: PRK10034; cl15264 195103002542 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 195103002543 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 195103002544 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 195103002545 ATP binding site [chemical binding]; other site 195103002546 Mg++ binding site [ion binding]; other site 195103002547 motif III; other site 195103002548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103002549 nucleotide binding region [chemical binding]; other site 195103002550 ATP-binding site [chemical binding]; other site 195103002551 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 195103002552 RNA binding site [nucleotide binding]; other site 195103002553 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103002554 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 195103002555 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002556 sugar binding site [chemical binding]; other site 195103002557 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 195103002558 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 195103002559 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 195103002560 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002561 sugar binding site [chemical binding]; other site 195103002562 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 195103002563 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002564 sugar binding site [chemical binding]; other site 195103002565 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002566 sugar binding site [chemical binding]; other site 195103002567 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103002568 Interdomain contacts; other site 195103002569 Cytokine receptor motif; other site 195103002570 alanine racemase; Reviewed; Region: alr; PRK00053 195103002571 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 195103002572 active site 195103002573 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195103002574 dimer interface [polypeptide binding]; other site 195103002575 substrate binding site [chemical binding]; other site 195103002576 catalytic residues [active] 195103002577 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 195103002578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002579 Coenzyme A binding pocket [chemical binding]; other site 195103002580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103002581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103002582 ATP binding site [chemical binding]; other site 195103002583 Mg2+ binding site [ion binding]; other site 195103002584 G-X-G motif; other site 195103002585 Accessory gene regulator B; Region: AgrB; smart00793 195103002586 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 195103002587 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 195103002588 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 195103002589 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 195103002590 active site 195103002591 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 195103002592 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 195103002593 putative acetyltransferase; Provisional; Region: PRK03624 195103002594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002595 Coenzyme A binding pocket [chemical binding]; other site 195103002596 Uncharacterized conserved protein [Function unknown]; Region: COG1284 195103002597 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103002598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 195103002599 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 195103002600 Probable transposase; Region: OrfB_IS605; pfam01385 195103002601 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 195103002602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002603 Coenzyme A binding pocket [chemical binding]; other site 195103002604 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 195103002605 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 195103002606 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 195103002607 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002608 sugar binding site [chemical binding]; other site 195103002609 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002610 sugar binding site [chemical binding]; other site 195103002611 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 195103002612 hypothetical protein; Provisional; Region: PRK00967 195103002613 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 195103002614 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 195103002615 Walker A/P-loop; other site 195103002616 ATP binding site [chemical binding]; other site 195103002617 Q-loop/lid; other site 195103002618 ABC transporter signature motif; other site 195103002619 Walker B; other site 195103002620 D-loop; other site 195103002621 H-loop/switch region; other site 195103002622 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 195103002623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103002624 S-adenosylmethionine binding site [chemical binding]; other site 195103002625 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 195103002626 putative active site [active] 195103002627 putative CoA binding site [chemical binding]; other site 195103002628 nudix motif; other site 195103002629 metal binding site [ion binding]; metal-binding site 195103002630 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195103002631 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103002632 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 195103002633 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 195103002634 putative active site [active] 195103002635 metal binding site [ion binding]; metal-binding site 195103002636 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 195103002637 putative hexamer interface [polypeptide binding]; other site 195103002638 putative hexagonal pore; other site 195103002639 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 195103002640 G1 box; other site 195103002641 GTP/Mg2+ binding site [chemical binding]; other site 195103002642 G2 box; other site 195103002643 Switch I region; other site 195103002644 G3 box; other site 195103002645 Switch II region; other site 195103002646 G4 box; other site 195103002647 G5 box; other site 195103002648 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 195103002649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103002650 active site 195103002651 phosphorylation site [posttranslational modification] 195103002652 intermolecular recognition site; other site 195103002653 dimerization interface [polypeptide binding]; other site 195103002654 ANTAR domain; Region: ANTAR; pfam03861 195103002655 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 195103002656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 195103002657 Histidine kinase; Region: HisKA_2; pfam07568 195103002658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 195103002659 Mg2+ binding site [ion binding]; other site 195103002660 G-X-G motif; other site 195103002661 Ethanolamine utilisation protein EutA; Region: EutA; pfam06277 195103002662 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 195103002663 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 195103002664 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 195103002665 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 195103002666 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 195103002667 putative hexamer interface [polypeptide binding]; other site 195103002668 putative hexagonal pore; other site 195103002669 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 195103002670 putative hexamer interface [polypeptide binding]; other site 195103002671 putative hexagonal pore; other site 195103002672 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 195103002673 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 195103002674 Hexamer interface [polypeptide binding]; other site 195103002675 Hexagonal pore residue; other site 195103002676 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 195103002677 putative catalytic cysteine [active] 195103002678 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 195103002679 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 195103002680 Hexamer interface [polypeptide binding]; other site 195103002681 Putative hexagonal pore residue; other site 195103002682 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 195103002683 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 195103002684 Propanediol utilisation protein PduL; Region: PduL; pfam06130 195103002685 Propanediol utilisation protein PduL; Region: PduL; pfam06130 195103002686 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 195103002687 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 195103002688 Hexamer/Pentamer interface [polypeptide binding]; other site 195103002689 central pore; other site 195103002690 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 195103002691 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 195103002692 putative hexamer interface [polypeptide binding]; other site 195103002693 putative hexagonal pore; other site 195103002694 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 195103002695 putative hexamer interface [polypeptide binding]; other site 195103002696 putative hexagonal pore; other site 195103002697 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 195103002698 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 195103002699 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 195103002700 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 195103002701 catalytic residues [active] 195103002702 dimer interface [polypeptide binding]; other site 195103002703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002704 Coenzyme A binding pocket [chemical binding]; other site 195103002705 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 195103002706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195103002707 substrate binding pocket [chemical binding]; other site 195103002708 membrane-bound complex binding site; other site 195103002709 hinge residues; other site 195103002710 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 195103002711 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 195103002712 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 195103002713 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 195103002714 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 195103002715 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 195103002716 NAD(P) binding site [chemical binding]; other site 195103002717 homodimer interface [polypeptide binding]; other site 195103002718 substrate binding site [chemical binding]; other site 195103002719 active site 195103002720 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 195103002721 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 195103002722 inhibitor-cofactor binding pocket; inhibition site 195103002723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103002724 catalytic residue [active] 195103002725 Bacterial sugar transferase; Region: Bac_transf; pfam02397 195103002726 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 195103002727 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 195103002728 Ligand binding site; other site 195103002729 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103002730 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 195103002731 putative ADP-binding pocket [chemical binding]; other site 195103002732 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 195103002733 LicD family; Region: LicD; pfam04991 195103002734 Chain length determinant protein; Region: Wzz; cl15801 195103002735 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 195103002736 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195103002737 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 195103002738 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 195103002739 Class III ribonucleotide reductase; Region: RNR_III; cd01675 195103002740 effector binding site; other site 195103002741 active site 195103002742 Zn binding site [ion binding]; other site 195103002743 glycine loop; other site 195103002744 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 195103002745 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 195103002746 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 195103002747 Int/Topo IB signature motif; other site 195103002748 Domain of unknown function (DUF955); Region: DUF955; pfam06114 195103002749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 195103002750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103002751 non-specific DNA binding site [nucleotide binding]; other site 195103002752 salt bridge; other site 195103002753 sequence-specific DNA binding site [nucleotide binding]; other site 195103002754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103002755 non-specific DNA binding site [nucleotide binding]; other site 195103002756 salt bridge; other site 195103002757 sequence-specific DNA binding site [nucleotide binding]; other site 195103002758 BRO family, N-terminal domain; Region: Bro-N; smart01040 195103002759 ORF6C domain; Region: ORF6C; pfam10552 195103002760 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 195103002761 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 195103002762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103002763 DNA-binding site [nucleotide binding]; DNA binding site 195103002764 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 195103002765 Terminase small subunit; Region: Terminase_2; pfam03592 195103002766 Phage terminase large subunit; Region: Terminase_3; cl12054 195103002767 Terminase-like family; Region: Terminase_6; pfam03237 195103002768 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 195103002769 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 195103002770 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 195103002771 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 195103002772 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 195103002773 Rho Binding; Region: Rho_Binding; pfam08912 195103002774 Parvovirus non-structural protein NS1; Region: Parvo_NS1; pfam01057 195103002775 Tellurite resistance protein TerB; Region: TerB; cl17311 195103002776 Holin family; Region: Phage_holin_4; pfam05105 195103002777 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 195103002778 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 195103002779 active site 195103002780 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103002781 Bacterial SH3 domain homologues; Region: SH3b; smart00287 195103002782 Restriction endonuclease; Region: Mrr_cat; pfam04471 195103002783 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 195103002784 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 195103002785 Zn binding site [ion binding]; other site 195103002786 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 195103002787 putative hydrolase; Provisional; Region: PRK02113 195103002788 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 195103002789 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 195103002790 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 195103002791 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 195103002792 Metal-binding active site; metal-binding site 195103002793 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 195103002794 catalytic site [active] 195103002795 BNR repeat-like domain; Region: BNR_2; pfam13088 195103002796 Asp-box motif; other site 195103002797 YCII-related domain; Region: YCII; cl00999 195103002798 CAAX protease self-immunity; Region: Abi; pfam02517 195103002799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 195103002800 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 195103002801 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 195103002802 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 195103002803 SdpI/YhfL protein family; Region: SdpI; pfam13630 195103002804 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 195103002805 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 195103002806 CAAX protease self-immunity; Region: Abi; pfam02517 195103002807 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 195103002808 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 195103002809 metal binding site [ion binding]; metal-binding site 195103002810 dimer interface [polypeptide binding]; other site 195103002811 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 195103002812 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 195103002813 putative active site [active] 195103002814 substrate binding site [chemical binding]; other site 195103002815 putative cosubstrate binding site; other site 195103002816 catalytic site [active] 195103002817 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 195103002818 substrate binding site [chemical binding]; other site 195103002819 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 195103002820 putative active site [active] 195103002821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 195103002822 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 195103002823 Probable transposase; Region: OrfB_IS605; pfam01385 195103002824 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 195103002825 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 195103002826 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 195103002827 G1 box; other site 195103002828 GTP/Mg2+ binding site [chemical binding]; other site 195103002829 Switch I region; other site 195103002830 G2 box; other site 195103002831 G3 box; other site 195103002832 Switch II region; other site 195103002833 G4 box; other site 195103002834 G5 box; other site 195103002835 Nucleoside recognition; Region: Gate; pfam07670 195103002836 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 195103002837 FeoA domain; Region: FeoA; cl00838 195103002838 Tim44-like domain; Region: Tim44; cl09208 195103002839 hypothetical protein; Provisional; Region: PRK06771 195103002840 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 195103002841 putative active site [active] 195103002842 putative NTP binding site [chemical binding]; other site 195103002843 putative nucleic acid binding site [nucleotide binding]; other site 195103002844 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 195103002845 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 195103002846 putative active site [active] 195103002847 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 195103002848 putative active site [active] 195103002849 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 195103002850 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 195103002851 cofactor binding site; other site 195103002852 DNA binding site [nucleotide binding] 195103002853 substrate interaction site [chemical binding]; other site 195103002854 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 195103002855 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 195103002856 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 195103002857 cofactor binding site; other site 195103002858 DNA binding site [nucleotide binding] 195103002859 substrate interaction site [chemical binding]; other site 195103002860 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 195103002861 Domain of unknown function (DUF955); Region: DUF955; pfam06114 195103002862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103002863 sequence-specific DNA binding site [nucleotide binding]; other site 195103002864 salt bridge; other site 195103002865 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 195103002866 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 195103002867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 195103002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103002869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195103002870 putative substrate translocation pore; other site 195103002871 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 195103002872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103002873 dimerization interface [polypeptide binding]; other site 195103002874 putative Zn2+ binding site [ion binding]; other site 195103002875 putative DNA binding site [nucleotide binding]; other site 195103002876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 195103002877 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 195103002878 active site 195103002879 8-oxo-dGMP binding site [chemical binding]; other site 195103002880 nudix motif; other site 195103002881 metal binding site [ion binding]; metal-binding site 195103002882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103002883 non-specific DNA binding site [nucleotide binding]; other site 195103002884 salt bridge; other site 195103002885 sequence-specific DNA binding site [nucleotide binding]; other site 195103002886 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 195103002887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 195103002888 FeS/SAM binding site; other site 195103002889 Radical SAM superfamily; Region: Radical_SAM; pfam04055 195103002890 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 195103002891 B3/4 domain; Region: B3_4; pfam03483 195103002892 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 195103002893 nudix motif; other site 195103002894 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 195103002895 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 195103002896 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 195103002897 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 195103002898 dimer interface [polypeptide binding]; other site 195103002899 active site 195103002900 metal binding site [ion binding]; metal-binding site 195103002901 Cupin domain; Region: Cupin_2; pfam07883 195103002902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103002903 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103002904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103002905 L-fucose isomerase; Provisional; Region: fucI; PRK10991 195103002906 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 195103002907 hexamer (dimer of trimers) interface [polypeptide binding]; other site 195103002908 trimer interface [polypeptide binding]; other site 195103002909 substrate binding site [chemical binding]; other site 195103002910 Mn binding site [ion binding]; other site 195103002911 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 195103002912 N- and C-terminal domain interface [polypeptide binding]; other site 195103002913 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 195103002914 active site 195103002915 putative catalytic site [active] 195103002916 metal binding site [ion binding]; metal-binding site 195103002917 ATP binding site [chemical binding]; other site 195103002918 carbohydrate binding site [chemical binding]; other site 195103002919 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 195103002920 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 195103002921 intersubunit interface [polypeptide binding]; other site 195103002922 active site 195103002923 Zn2+ binding site [ion binding]; other site 195103002924 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 195103002925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103002926 putative substrate translocation pore; other site 195103002927 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 195103002928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103002929 non-specific DNA binding site [nucleotide binding]; other site 195103002930 salt bridge; other site 195103002931 sequence-specific DNA binding site [nucleotide binding]; other site 195103002932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103002933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103002934 active site 195103002935 phosphorylation site [posttranslational modification] 195103002936 intermolecular recognition site; other site 195103002937 dimerization interface [polypeptide binding]; other site 195103002938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103002939 DNA binding site [nucleotide binding] 195103002940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103002941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103002942 dimer interface [polypeptide binding]; other site 195103002943 phosphorylation site [posttranslational modification] 195103002944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103002945 ATP binding site [chemical binding]; other site 195103002946 Mg2+ binding site [ion binding]; other site 195103002947 G-X-G motif; other site 195103002948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103002949 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 195103002950 active site 195103002951 motif I; other site 195103002952 motif II; other site 195103002953 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 195103002954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002955 Coenzyme A binding pocket [chemical binding]; other site 195103002956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103002957 Coenzyme A binding pocket [chemical binding]; other site 195103002958 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 195103002959 nudix motif; other site 195103002960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195103002961 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 195103002962 substrate binding pocket [chemical binding]; other site 195103002963 membrane-bound complex binding site; other site 195103002964 hinge residues; other site 195103002965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 195103002966 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 195103002967 CotJB protein; Region: CotJB; pfam12652 195103002968 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 195103002969 dimanganese center [ion binding]; other site 195103002970 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 195103002971 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 195103002972 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 195103002973 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 195103002974 active site turn [active] 195103002975 phosphorylation site [posttranslational modification] 195103002976 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002977 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002978 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103002979 Peptidase M60-like family; Region: M60-like; pfam13402 195103002980 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 195103002981 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 195103002982 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 195103002983 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 195103002984 4Fe-4S binding domain; Region: Fer4; pfam00037 195103002985 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 195103002986 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 195103002987 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 195103002988 Rubredoxin; Region: Rubredoxin; pfam00301 195103002989 iron binding site [ion binding]; other site 195103002990 Rubrerythrin [Energy production and conversion]; Region: COG1592 195103002991 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 195103002992 binuclear metal center [ion binding]; other site 195103002993 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103002994 iron binding site [ion binding]; other site 195103002995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 195103002996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 195103002997 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 195103002998 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103002999 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 195103003000 MarR family; Region: MarR; pfam01047 195103003001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 195103003002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103003003 Coenzyme A binding pocket [chemical binding]; other site 195103003004 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 195103003005 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 195103003006 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 195103003007 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 195103003008 glycogen binding site [chemical binding]; other site 195103003009 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 195103003010 carbohydrate binding site [chemical binding]; other site 195103003011 pullulanase, type I; Region: pulA_typeI; TIGR02104 195103003012 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 195103003013 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 195103003014 Ca binding site [ion binding]; other site 195103003015 active site 195103003016 catalytic site [active] 195103003017 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 195103003018 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 195103003019 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 195103003020 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 195103003021 carbohydrate binding site [chemical binding]; other site 195103003022 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 195103003023 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 195103003024 active site 195103003025 catalytic site [active] 195103003026 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 195103003027 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 195103003028 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 195103003029 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 195103003030 putative active site [active] 195103003031 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 195103003032 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 195103003033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103003034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 195103003035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103003036 Walker A/P-loop; other site 195103003037 ATP binding site [chemical binding]; other site 195103003038 Q-loop/lid; other site 195103003039 ABC transporter signature motif; other site 195103003040 Walker B; other site 195103003041 D-loop; other site 195103003042 H-loop/switch region; other site 195103003043 SdpI/YhfL protein family; Region: SdpI; pfam13630 195103003044 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 195103003045 Sulfatase; Region: Sulfatase; cl17466 195103003046 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 195103003047 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 195103003048 putative active site [active] 195103003049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 195103003050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103003051 putative DNA binding site [nucleotide binding]; other site 195103003052 putative Zn2+ binding site [ion binding]; other site 195103003053 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 195103003054 Acyltransferase family; Region: Acyl_transf_3; pfam01757 195103003055 Response regulator receiver domain; Region: Response_reg; pfam00072 195103003056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103003057 active site 195103003058 phosphorylation site [posttranslational modification] 195103003059 intermolecular recognition site; other site 195103003060 dimerization interface [polypeptide binding]; other site 195103003061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103003062 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103003063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103003064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103003065 dimerization interface [polypeptide binding]; other site 195103003066 Histidine kinase; Region: His_kinase; pfam06580 195103003067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 195103003068 ATP binding site [chemical binding]; other site 195103003069 Mg2+ binding site [ion binding]; other site 195103003070 G-X-G motif; other site 195103003071 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 195103003072 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 195103003073 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 195103003074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103003075 dimer interface [polypeptide binding]; other site 195103003076 conserved gate region; other site 195103003077 putative PBP binding loops; other site 195103003078 ABC-ATPase subunit interface; other site 195103003079 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 195103003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103003081 dimer interface [polypeptide binding]; other site 195103003082 conserved gate region; other site 195103003083 putative PBP binding loops; other site 195103003084 ABC-ATPase subunit interface; other site 195103003085 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 195103003086 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 195103003087 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 195103003088 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 195103003089 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 195103003090 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 195103003091 active site 195103003092 catalytic residues [active] 195103003093 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 195103003094 putative active site [active] 195103003095 catalytic triad [active] 195103003096 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 195103003097 PA/protease domain interface [polypeptide binding]; other site 195103003098 putative integrin binding motif; other site 195103003099 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 195103003100 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 195103003101 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 195103003102 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 195103003103 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 195103003104 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 195103003105 G1 box; other site 195103003106 GTP/Mg2+ binding site [chemical binding]; other site 195103003107 Switch I region; other site 195103003108 G2 box; other site 195103003109 G3 box; other site 195103003110 Switch II region; other site 195103003111 G4 box; other site 195103003112 G5 box; other site 195103003113 Nucleoside recognition; Region: Gate; pfam07670 195103003114 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 195103003115 Nucleoside recognition; Region: Gate; pfam07670 195103003116 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 195103003117 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 195103003118 FeoC like transcriptional regulator; Region: FeoC; cl17677 195103003119 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 195103003120 Coenzyme A binding pocket [chemical binding]; other site 195103003121 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 195103003122 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 195103003123 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 195103003124 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 195103003125 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 195103003126 FMN binding site [chemical binding]; other site 195103003127 dimer interface [polypeptide binding]; other site 195103003128 Predicted transcriptional regulators [Transcription]; Region: COG1733 195103003129 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 195103003130 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 195103003131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103003132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103003133 active site 195103003134 phosphorylation site [posttranslational modification] 195103003135 intermolecular recognition site; other site 195103003136 dimerization interface [polypeptide binding]; other site 195103003137 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 195103003138 DNA binding site [nucleotide binding] 195103003139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103003140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103003141 dimer interface [polypeptide binding]; other site 195103003142 phosphorylation site [posttranslational modification] 195103003143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103003144 ATP binding site [chemical binding]; other site 195103003145 Mg2+ binding site [ion binding]; other site 195103003146 G-X-G motif; other site 195103003147 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 195103003148 putative metal binding residues [ion binding]; other site 195103003149 signature motif; other site 195103003150 dimer interface [polypeptide binding]; other site 195103003151 active site 195103003152 polyP binding site; other site 195103003153 substrate binding site [chemical binding]; other site 195103003154 acceptor-phosphate pocket; other site 195103003155 CotH protein; Region: CotH; pfam08757 195103003156 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 195103003157 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 195103003158 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 195103003159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195103003160 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 195103003161 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 195103003162 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 195103003163 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103003164 ATP binding site [chemical binding]; other site 195103003165 putative Mg++ binding site [ion binding]; other site 195103003166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103003167 nucleotide binding region [chemical binding]; other site 195103003168 ATP-binding site [chemical binding]; other site 195103003169 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 195103003170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103003171 RNA binding surface [nucleotide binding]; other site 195103003172 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 195103003173 probable active site [active] 195103003174 magnesium-transporting ATPase; Provisional; Region: PRK15122 195103003175 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 195103003176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195103003177 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 195103003178 Soluble P-type ATPase [General function prediction only]; Region: COG4087 195103003179 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 195103003180 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 195103003181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 195103003182 NAD(P) binding site [chemical binding]; other site 195103003183 active site 195103003184 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 195103003185 MgtC family; Region: MgtC; pfam02308 195103003186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103003187 Coenzyme A binding pocket [chemical binding]; other site 195103003188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 195103003189 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 195103003190 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 195103003191 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195103003192 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 195103003193 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 195103003194 PAS domain; Region: PAS; smart00091 195103003195 PAS domain S-box; Region: sensory_box; TIGR00229 195103003196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 195103003197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195103003198 metal binding site [ion binding]; metal-binding site 195103003199 active site 195103003200 I-site; other site 195103003201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103003202 Zn2+ binding site [ion binding]; other site 195103003203 Mg2+ binding site [ion binding]; other site 195103003204 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 195103003205 putative FMN binding site [chemical binding]; other site 195103003206 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 195103003207 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 195103003208 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 195103003209 amphipathic channel; other site 195103003210 Asn-Pro-Ala signature motifs; other site 195103003211 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 195103003212 Sensory domain found in PocR; Region: PocR; pfam10114 195103003213 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 195103003214 Histidine kinase; Region: His_kinase; pfam06580 195103003215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103003216 ATP binding site [chemical binding]; other site 195103003217 Mg2+ binding site [ion binding]; other site 195103003218 G-X-G motif; other site 195103003219 Response regulator receiver domain; Region: Response_reg; pfam00072 195103003220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103003221 active site 195103003222 phosphorylation site [posttranslational modification] 195103003223 intermolecular recognition site; other site 195103003224 dimerization interface [polypeptide binding]; other site 195103003225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103003226 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103003227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103003228 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 195103003229 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 195103003230 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 195103003231 alpha-beta subunit interface [polypeptide binding]; other site 195103003232 alpha-gamma subunit interface [polypeptide binding]; other site 195103003233 active site 195103003234 substrate and K+ binding site; other site 195103003235 K+ binding site [ion binding]; other site 195103003236 cobalamin binding site [chemical binding]; other site 195103003237 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 195103003238 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 195103003239 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 195103003240 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 195103003241 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 195103003242 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 195103003243 Domain of unknown function (DUF336); Region: DUF336; pfam03928 195103003244 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 195103003245 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 195103003246 dimer interface [polypeptide binding]; other site 195103003247 active site 195103003248 metal binding site [ion binding]; metal-binding site 195103003249 inner membrane transporter YjeM; Provisional; Region: PRK15238 195103003250 Predicted membrane protein [Function unknown]; Region: COG2717 195103003251 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 195103003252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103003253 Coenzyme A binding pocket [chemical binding]; other site 195103003254 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 195103003255 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 195103003256 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 195103003257 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 195103003258 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 195103003259 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 195103003260 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 195103003261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103003262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103003263 active site 195103003264 phosphorylation site [posttranslational modification] 195103003265 intermolecular recognition site; other site 195103003266 dimerization interface [polypeptide binding]; other site 195103003267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103003268 DNA binding site [nucleotide binding] 195103003269 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 195103003270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103003271 Walker A/P-loop; other site 195103003272 ATP binding site [chemical binding]; other site 195103003273 Q-loop/lid; other site 195103003274 ABC transporter signature motif; other site 195103003275 Walker B; other site 195103003276 D-loop; other site 195103003277 H-loop/switch region; other site 195103003278 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 195103003279 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 195103003280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103003281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103003282 dimer interface [polypeptide binding]; other site 195103003283 phosphorylation site [posttranslational modification] 195103003284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103003285 ATP binding site [chemical binding]; other site 195103003286 Mg2+ binding site [ion binding]; other site 195103003287 G-X-G motif; other site 195103003288 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 195103003289 flavoprotein, HI0933 family; Region: TIGR00275 195103003290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 195103003291 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 195103003292 catalytic residues [active] 195103003293 dimer interface [polypeptide binding]; other site 195103003294 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195103003295 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195103003296 Walker A/P-loop; other site 195103003297 ATP binding site [chemical binding]; other site 195103003298 Q-loop/lid; other site 195103003299 ABC transporter signature motif; other site 195103003300 Walker B; other site 195103003301 D-loop; other site 195103003302 H-loop/switch region; other site 195103003303 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 195103003304 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 195103003305 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 195103003306 FtsX-like permease family; Region: FtsX; pfam02687 195103003307 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 195103003308 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 195103003309 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 195103003310 nudix motif; other site 195103003311 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 195103003312 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 195103003313 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 195103003314 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 195103003315 MarR family; Region: MarR; pfam01047 195103003316 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 195103003317 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 195103003318 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195103003319 potassium-transporting ATPase subunit C; Provisional; Region: PRK13996 195103003320 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 195103003321 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 195103003322 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 195103003323 Ligand Binding Site [chemical binding]; other site 195103003324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103003325 dimer interface [polypeptide binding]; other site 195103003326 phosphorylation site [posttranslational modification] 195103003327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103003328 ATP binding site [chemical binding]; other site 195103003329 Mg2+ binding site [ion binding]; other site 195103003330 G-X-G motif; other site 195103003331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103003332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103003333 active site 195103003334 phosphorylation site [posttranslational modification] 195103003335 intermolecular recognition site; other site 195103003336 dimerization interface [polypeptide binding]; other site 195103003337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103003338 DNA binding site [nucleotide binding] 195103003339 inner membrane transporter YjeM; Provisional; Region: PRK15238 195103003340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195103003341 metal binding site [ion binding]; metal-binding site 195103003342 active site 195103003343 I-site; other site 195103003344 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 195103003345 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 195103003346 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 195103003347 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 195103003348 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 195103003349 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 195103003350 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 195103003351 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 195103003352 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 195103003353 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 195103003354 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 195103003355 Predicted membrane protein [Function unknown]; Region: COG1289 195103003356 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 195103003357 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 195103003358 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 195103003359 TrkA-C domain; Region: TrkA_C; pfam02080 195103003360 Methyltransferase domain; Region: Methyltransf_32; pfam13679 195103003361 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 195103003362 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 195103003363 active site 195103003364 dimer interface [polypeptide binding]; other site 195103003365 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 195103003366 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 195103003367 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 195103003368 G1 box; other site 195103003369 putative GEF interaction site [polypeptide binding]; other site 195103003370 GTP/Mg2+ binding site [chemical binding]; other site 195103003371 Switch I region; other site 195103003372 G2 box; other site 195103003373 G3 box; other site 195103003374 Switch II region; other site 195103003375 G4 box; other site 195103003376 G5 box; other site 195103003377 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 195103003378 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 195103003379 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 195103003380 K+ potassium transporter; Region: K_trans; pfam02705 195103003381 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 195103003382 Ferritin-like domain; Region: Ferritin; pfam00210 195103003383 ferroxidase diiron center [ion binding]; other site 195103003384 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 195103003385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103003386 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103003387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103003388 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 195103003389 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 195103003390 putative active site [active] 195103003391 Uncharacterized conserved protein [Function unknown]; Region: COG4127 195103003392 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 195103003393 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 195103003394 Predicted membrane protein [Function unknown]; Region: COG1288 195103003395 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 195103003396 PAS fold; Region: PAS_4; pfam08448 195103003397 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 195103003398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195103003399 putative active site [active] 195103003400 heme pocket [chemical binding]; other site 195103003401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103003402 dimer interface [polypeptide binding]; other site 195103003403 phosphorylation site [posttranslational modification] 195103003404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103003405 ATP binding site [chemical binding]; other site 195103003406 Mg2+ binding site [ion binding]; other site 195103003407 G-X-G motif; other site 195103003408 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 195103003409 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 195103003410 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 195103003411 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 195103003412 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 195103003413 putative L-serine binding site [chemical binding]; other site 195103003414 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 195103003415 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 195103003416 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 195103003417 Ligand Binding Site [chemical binding]; other site 195103003418 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 195103003419 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 195103003420 dimerization interface 3.5A [polypeptide binding]; other site 195103003421 active site 195103003422 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 195103003423 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 195103003424 FMN binding site [chemical binding]; other site 195103003425 substrate binding site [chemical binding]; other site 195103003426 putative catalytic residue [active] 195103003427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 195103003428 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195103003429 ligand binding site [chemical binding]; other site 195103003430 flexible hinge region; other site 195103003431 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 195103003432 non-specific DNA interactions [nucleotide binding]; other site 195103003433 DNA binding site [nucleotide binding] 195103003434 sequence specific DNA binding site [nucleotide binding]; other site 195103003435 putative cAMP binding site [chemical binding]; other site 195103003436 Radical SAM superfamily; Region: Radical_SAM; pfam04055 195103003437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103003438 FeS/SAM binding site; other site 195103003439 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 195103003440 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 195103003441 putative oligomer interface [polypeptide binding]; other site 195103003442 putative active site [active] 195103003443 metal binding site [ion binding]; metal-binding site 195103003444 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 195103003445 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 195103003446 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 195103003447 HIGH motif; other site 195103003448 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 195103003449 active site 195103003450 KMSKS motif; other site 195103003451 Probable zinc-binding domain; Region: zf-trcl; pfam13451 195103003452 Protein of unknown function, DUF488; Region: DUF488; pfam04343 195103003453 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 195103003454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103003455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103003456 homodimer interface [polypeptide binding]; other site 195103003457 catalytic residue [active] 195103003458 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 195103003459 HPr kinase/phosphorylase; Provisional; Region: PRK05428 195103003460 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 195103003461 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 195103003462 Hpr binding site; other site 195103003463 active site 195103003464 homohexamer subunit interaction site [polypeptide binding]; other site 195103003465 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 195103003466 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 195103003467 oligomer interface [polypeptide binding]; other site 195103003468 metal binding site [ion binding]; metal-binding site 195103003469 metal binding site [ion binding]; metal-binding site 195103003470 putative Cl binding site [ion binding]; other site 195103003471 aspartate ring; other site 195103003472 hydrophobic gate; other site 195103003473 periplasmic entrance; other site 195103003474 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 195103003475 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 195103003476 oligomer interface [polypeptide binding]; other site 195103003477 putative active site [active] 195103003478 metal binding site [ion binding]; metal-binding site 195103003479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195103003480 metal binding site [ion binding]; metal-binding site 195103003481 active site 195103003482 I-site; other site 195103003483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 195103003484 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 195103003485 active site 195103003486 dimer interfaces [polypeptide binding]; other site 195103003487 catalytic residues [active] 195103003488 Bacteriophage holin; Region: Phage_holin_1; cl02344 195103003489 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 195103003490 homotrimer interaction site [polypeptide binding]; other site 195103003491 putative active site [active] 195103003492 TSCPD domain; Region: TSCPD; cl14834 195103003493 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 195103003494 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 195103003495 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 195103003496 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103003497 Rubredoxin; Region: Rubredoxin; pfam00301 195103003498 iron binding site [ion binding]; other site 195103003499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 195103003500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195103003501 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 195103003502 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 195103003503 active site 195103003504 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 195103003505 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 195103003506 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 195103003507 glutamine binding [chemical binding]; other site 195103003508 catalytic triad [active] 195103003509 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 195103003510 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 195103003511 chorismate binding enzyme; Region: Chorismate_bind; cl10555 195103003512 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 195103003513 homodimer interface [polypeptide binding]; other site 195103003514 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 195103003515 substrate-cofactor binding pocket; other site 195103003516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103003517 catalytic residue [active] 195103003518 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 195103003519 homodecamer interface [polypeptide binding]; other site 195103003520 GTP cyclohydrolase I; Provisional; Region: PLN03044 195103003521 active site 195103003522 putative catalytic site residues [active] 195103003523 zinc binding site [ion binding]; other site 195103003524 GTP-CH-I/GFRP interaction surface; other site 195103003525 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103003526 Zn2+ binding site [ion binding]; other site 195103003527 Mg2+ binding site [ion binding]; other site 195103003528 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 195103003529 dihydropteroate synthase; Region: DHPS; TIGR01496 195103003530 substrate binding pocket [chemical binding]; other site 195103003531 dimer interface [polypeptide binding]; other site 195103003532 inhibitor binding site; inhibition site 195103003533 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 195103003534 homooctamer interface [polypeptide binding]; other site 195103003535 active site 195103003536 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 195103003537 catalytic center binding site [active] 195103003538 ATP binding site [chemical binding]; other site 195103003539 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 195103003540 active site 195103003541 domain interfaces; other site 195103003542 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 195103003543 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 195103003544 active site 195103003545 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 195103003546 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 195103003547 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 195103003548 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 195103003549 camphor resistance protein CrcB; Provisional; Region: PRK14199 195103003550 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 195103003551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 195103003552 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 195103003553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103003554 dimerization interface [polypeptide binding]; other site 195103003555 putative DNA binding site [nucleotide binding]; other site 195103003556 putative Zn2+ binding site [ion binding]; other site 195103003557 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 195103003558 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 195103003559 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 195103003560 putative metal binding site [ion binding]; other site 195103003561 dimer interface [polypeptide binding]; other site 195103003562 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 195103003563 active site 195103003564 ATP binding site [chemical binding]; other site 195103003565 Phosphotransferase enzyme family; Region: APH; pfam01636 195103003566 substrate binding site [chemical binding]; other site 195103003567 dimer interface [polypeptide binding]; other site 195103003568 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 195103003569 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 195103003570 active site pocket [active] 195103003571 putative dimer interface [polypeptide binding]; other site 195103003572 putative cataytic base [active] 195103003573 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 195103003574 Walker B motif; other site 195103003575 cobalamin synthase; Reviewed; Region: cobS; PRK00235 195103003576 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 195103003577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 195103003578 catalytic core [active] 195103003579 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 195103003580 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 195103003581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103003582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103003583 homodimer interface [polypeptide binding]; other site 195103003584 catalytic residue [active] 195103003585 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 195103003586 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 195103003587 putative binding site residues; other site 195103003588 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 195103003589 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195103003590 ABC-ATPase subunit interface; other site 195103003591 dimer interface [polypeptide binding]; other site 195103003592 putative PBP binding regions; other site 195103003593 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 195103003594 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 195103003595 Walker A/P-loop; other site 195103003596 ATP binding site [chemical binding]; other site 195103003597 Q-loop/lid; other site 195103003598 ABC transporter signature motif; other site 195103003599 Walker B; other site 195103003600 D-loop; other site 195103003601 H-loop/switch region; other site 195103003602 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 195103003603 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 195103003604 Ligand Binding Site [chemical binding]; other site 195103003605 cobyric acid synthase; Provisional; Region: PRK00784 195103003606 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 195103003607 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 195103003608 catalytic triad [active] 195103003609 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 195103003610 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 195103003611 putative active site [active] 195103003612 putative catalytic site [active] 195103003613 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 195103003614 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103003615 Interdomain contacts; other site 195103003616 Cytokine receptor motif; other site 195103003617 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103003618 sugar binding site [chemical binding]; other site 195103003619 Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759 195103003620 putative dockerin binding interface; other site 195103003621 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103003622 sugar binding site [chemical binding]; other site 195103003623 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 195103003624 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 195103003625 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103003626 Interdomain contacts; other site 195103003627 Cytokine receptor motif; other site 195103003628 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 195103003629 Methyltransferase domain; Region: Methyltransf_31; pfam13847 195103003630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103003631 S-adenosylmethionine binding site [chemical binding]; other site 195103003632 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 195103003633 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 195103003634 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 195103003635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103003636 S-adenosylmethionine binding site [chemical binding]; other site 195103003637 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 195103003638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 195103003639 active site residue [active] 195103003640 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 195103003641 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 195103003642 active site residue [active] 195103003643 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 195103003644 active site residue [active] 195103003645 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 195103003646 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 195103003647 putative catalytic site [active] 195103003648 putative metal binding site [ion binding]; other site 195103003649 putative phosphate binding site [ion binding]; other site 195103003650 histidinol-phosphatase; Reviewed; Region: PRK08123 195103003651 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 195103003652 active site 195103003653 dimer interface [polypeptide binding]; other site 195103003654 Tetratricopeptide repeat; Region: TPR_16; pfam13432 195103003655 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 195103003656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103003657 binding surface 195103003658 TPR motif; other site 195103003659 NAD synthetase; Reviewed; Region: nadE; PRK02628 195103003660 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 195103003661 multimer interface [polypeptide binding]; other site 195103003662 active site 195103003663 catalytic triad [active] 195103003664 protein interface 1 [polypeptide binding]; other site 195103003665 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 195103003666 homodimer interface [polypeptide binding]; other site 195103003667 NAD binding pocket [chemical binding]; other site 195103003668 ATP binding pocket [chemical binding]; other site 195103003669 Mg binding site [ion binding]; other site 195103003670 active-site loop [active] 195103003671 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 195103003672 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 195103003673 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 195103003674 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 195103003675 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195103003676 catalytic residue [active] 195103003677 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 195103003678 FMN-binding domain; Region: FMN_bind; pfam04205 195103003679 electron transport complex RsxE subunit; Provisional; Region: PRK12405 195103003680 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 195103003681 ferredoxin; Validated; Region: PRK07118 195103003682 Putative Fe-S cluster; Region: FeS; cl17515 195103003683 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 195103003684 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 195103003685 catalytic motif [active] 195103003686 Zn binding site [ion binding]; other site 195103003687 MarR family; Region: MarR_2; pfam12802 195103003688 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 195103003689 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 195103003690 dimer interface [polypeptide binding]; other site 195103003691 active site 195103003692 CoA binding pocket [chemical binding]; other site 195103003693 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 195103003694 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 195103003695 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 195103003696 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 195103003697 NAD(P) binding site [chemical binding]; other site 195103003698 homotetramer interface [polypeptide binding]; other site 195103003699 homodimer interface [polypeptide binding]; other site 195103003700 active site 195103003701 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 195103003702 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 195103003703 dimer interface [polypeptide binding]; other site 195103003704 active site 195103003705 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 195103003706 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 195103003707 carboxyltransferase (CT) interaction site; other site 195103003708 biotinylation site [posttranslational modification]; other site 195103003709 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 195103003710 biotin carboxylase; Validated; Region: PRK05586 195103003711 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 195103003712 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 195103003713 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 195103003714 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 195103003715 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 195103003716 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 195103003717 Predicted transcriptional regulators [Transcription]; Region: COG1695 195103003718 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 195103003719 Transcriptional regulator PadR-like family; Region: PadR; cl17335 195103003720 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 195103003721 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 195103003722 AP (apurinic/apyrimidinic) site pocket; other site 195103003723 DNA interaction; other site 195103003724 Metal-binding active site; metal-binding site 195103003725 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 195103003726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103003727 RNA binding surface [nucleotide binding]; other site 195103003728 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 195103003729 active site 195103003730 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 195103003731 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 195103003732 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 195103003733 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 195103003734 putative active site [active] 195103003735 flavoprotein, HI0933 family; Region: TIGR00275 195103003736 cytidylate kinase; Provisional; Region: cmk; PRK00023 195103003737 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 195103003738 CMP-binding site; other site 195103003739 The sites determining sugar specificity; other site 195103003740 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK12360 195103003741 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 195103003742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103003743 Coenzyme A binding pocket [chemical binding]; other site 195103003744 Helix-turn-helix domain; Region: HTH_17; pfam12728 195103003745 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 195103003746 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 195103003747 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 195103003748 active site 195103003749 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 195103003750 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 195103003751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103003752 FeS/SAM binding site; other site 195103003753 TRAM domain; Region: TRAM; pfam01938 195103003754 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 195103003755 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 195103003756 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 195103003757 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 195103003758 Pyruvate formate lyase 1; Region: PFL1; cd01678 195103003759 coenzyme A binding site [chemical binding]; other site 195103003760 active site 195103003761 catalytic residues [active] 195103003762 glycine loop; other site 195103003763 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 195103003764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103003765 FeS/SAM binding site; other site 195103003766 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 195103003767 MutS domain I; Region: MutS_I; pfam01624 195103003768 MutS domain II; Region: MutS_II; pfam05188 195103003769 MutS domain III; Region: MutS_III; pfam05192 195103003770 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 195103003771 Walker A/P-loop; other site 195103003772 ATP binding site [chemical binding]; other site 195103003773 Q-loop/lid; other site 195103003774 ABC transporter signature motif; other site 195103003775 Walker B; other site 195103003776 D-loop; other site 195103003777 H-loop/switch region; other site 195103003778 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 195103003779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103003780 ATP binding site [chemical binding]; other site 195103003781 Mg2+ binding site [ion binding]; other site 195103003782 G-X-G motif; other site 195103003783 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 195103003784 ATP binding site [chemical binding]; other site 195103003785 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 195103003786 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 195103003787 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 195103003788 bacterial Hfq-like; Region: Hfq; cd01716 195103003789 hexamer interface [polypeptide binding]; other site 195103003790 Sm1 motif; other site 195103003791 RNA binding site [nucleotide binding]; other site 195103003792 Sm2 motif; other site 195103003793 Aluminium resistance protein; Region: Alum_res; pfam06838 195103003794 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 195103003795 LexA repressor; Validated; Region: PRK00215 195103003796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103003797 putative DNA binding site [nucleotide binding]; other site 195103003798 putative Zn2+ binding site [ion binding]; other site 195103003799 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 195103003800 Catalytic site [active] 195103003801 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 195103003802 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 195103003803 active site 195103003804 DNA binding site [nucleotide binding] 195103003805 Int/Topo IB signature motif; other site 195103003806 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 195103003807 threonine dehydratase; Provisional; Region: PRK08198 195103003808 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 195103003809 tetramer interface [polypeptide binding]; other site 195103003810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103003811 catalytic residue [active] 195103003812 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 195103003813 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 195103003814 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 195103003815 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 195103003816 Predicted membrane protein [Function unknown]; Region: COG2364 195103003817 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103003818 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 195103003819 nudix motif; other site 195103003820 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 195103003821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103003822 motif II; other site 195103003823 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 195103003824 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 195103003825 active site 195103003826 putative catalytic site [active] 195103003827 DNA binding site [nucleotide binding] 195103003828 putative phosphate binding site [ion binding]; other site 195103003829 metal binding site A [ion binding]; metal-binding site 195103003830 AP binding site [nucleotide binding]; other site 195103003831 metal binding site B [ion binding]; metal-binding site 195103003832 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 195103003833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103003834 Coenzyme A binding pocket [chemical binding]; other site 195103003835 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103003836 active site 195103003837 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 195103003838 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 195103003839 heterodimer interface [polypeptide binding]; other site 195103003840 active site 195103003841 FMN binding site [chemical binding]; other site 195103003842 homodimer interface [polypeptide binding]; other site 195103003843 substrate binding site [chemical binding]; other site 195103003844 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 195103003845 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 195103003846 FAD binding pocket [chemical binding]; other site 195103003847 FAD binding motif [chemical binding]; other site 195103003848 phosphate binding motif [ion binding]; other site 195103003849 beta-alpha-beta structure motif; other site 195103003850 NAD binding pocket [chemical binding]; other site 195103003851 Iron coordination center [ion binding]; other site 195103003852 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 195103003853 active site 195103003854 dimer interface [polypeptide binding]; other site 195103003855 dihydroorotase; Validated; Region: pyrC; PRK09357 195103003856 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 195103003857 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 195103003858 active site 195103003859 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 195103003860 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 195103003861 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 195103003862 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 195103003863 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 195103003864 phosphofructokinase; Region: PFK_mixed; TIGR02483 195103003865 active site 195103003866 ADP/pyrophosphate binding site [chemical binding]; other site 195103003867 dimerization interface [polypeptide binding]; other site 195103003868 allosteric effector site; other site 195103003869 fructose-1,6-bisphosphate binding site; other site 195103003870 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 195103003871 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 195103003872 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 195103003873 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 195103003874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103003875 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 195103003876 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 195103003877 catalytic triad [active] 195103003878 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 195103003879 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 195103003880 VanW like protein; Region: VanW; pfam04294 195103003881 G5 domain; Region: G5; pfam07501 195103003882 Predicted membrane protein [Function unknown]; Region: COG4905 195103003883 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 195103003884 inner membrane transporter YjeM; Provisional; Region: PRK15238 195103003885 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 195103003886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103003887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103003888 dimerization interface [polypeptide binding]; other site 195103003889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103003890 dimer interface [polypeptide binding]; other site 195103003891 phosphorylation site [posttranslational modification] 195103003892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103003893 ATP binding site [chemical binding]; other site 195103003894 Mg2+ binding site [ion binding]; other site 195103003895 G-X-G motif; other site 195103003896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103003897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103003898 active site 195103003899 phosphorylation site [posttranslational modification] 195103003900 intermolecular recognition site; other site 195103003901 dimerization interface [polypeptide binding]; other site 195103003902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103003903 DNA binding site [nucleotide binding] 195103003904 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 195103003905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 195103003906 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103003907 nucleotide binding site [chemical binding]; other site 195103003908 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 195103003909 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 195103003910 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 195103003911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 195103003912 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 195103003913 hypothetical protein; Provisional; Region: PRK00955 195103003914 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 195103003915 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 195103003916 DEAD/DEAH box helicase; Region: DEAD; pfam00270 195103003917 DEAD_2; Region: DEAD_2; pfam06733 195103003918 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 195103003919 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103003920 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 195103003921 Phosphotransferase enzyme family; Region: APH; pfam01636 195103003922 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 195103003923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 195103003924 active site 195103003925 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 195103003926 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 195103003927 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195103003928 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 195103003929 Soluble P-type ATPase [General function prediction only]; Region: COG4087 195103003930 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 195103003931 stage V sporulation protein B; Region: spore_V_B; TIGR02900 195103003932 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 195103003933 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 195103003934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103003935 RNA binding surface [nucleotide binding]; other site 195103003936 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 195103003937 active site 195103003938 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 195103003939 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 195103003940 metal binding site [ion binding]; metal-binding site 195103003941 dimer interface [polypeptide binding]; other site 195103003942 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 195103003943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103003944 ATP binding site [chemical binding]; other site 195103003945 Family description; Region: UvrD_C_2; pfam13538 195103003946 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 195103003947 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 195103003948 active site 195103003949 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 195103003950 metal binding site 2 [ion binding]; metal-binding site 195103003951 putative DNA binding helix; other site 195103003952 metal binding site 1 [ion binding]; metal-binding site 195103003953 dimer interface [polypeptide binding]; other site 195103003954 structural Zn2+ binding site [ion binding]; other site 195103003955 dipeptidase PepV; Reviewed; Region: PRK07318 195103003956 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 195103003957 active site 195103003958 metal binding site [ion binding]; metal-binding site 195103003959 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 195103003960 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 195103003961 active site 195103003962 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 195103003963 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 195103003964 Walker A/P-loop; other site 195103003965 ATP binding site [chemical binding]; other site 195103003966 Q-loop/lid; other site 195103003967 ABC transporter signature motif; other site 195103003968 Walker B; other site 195103003969 D-loop; other site 195103003970 H-loop/switch region; other site 195103003971 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 195103003972 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195103003973 ABC-ATPase subunit interface; other site 195103003974 dimer interface [polypeptide binding]; other site 195103003975 putative PBP binding regions; other site 195103003976 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 195103003977 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 195103003978 putative ligand binding residues [chemical binding]; other site 195103003979 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 195103003980 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 195103003981 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 195103003982 active site 195103003983 SAM binding site [chemical binding]; other site 195103003984 homodimer interface [polypeptide binding]; other site 195103003985 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 195103003986 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 195103003987 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 195103003988 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 195103003989 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 195103003990 active site 195103003991 SAM binding site [chemical binding]; other site 195103003992 homodimer interface [polypeptide binding]; other site 195103003993 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 195103003994 active site 195103003995 SAM binding site [chemical binding]; other site 195103003996 homodimer interface [polypeptide binding]; other site 195103003997 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 195103003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103003999 S-adenosylmethionine binding site [chemical binding]; other site 195103004000 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 195103004001 active site 195103004002 putative homodimer interface [polypeptide binding]; other site 195103004003 SAM binding site [chemical binding]; other site 195103004004 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 195103004005 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 195103004006 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 195103004007 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 195103004008 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 195103004009 active site 195103004010 C-terminal domain interface [polypeptide binding]; other site 195103004011 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 195103004012 active site 195103004013 N-terminal domain interface [polypeptide binding]; other site 195103004014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 195103004015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 195103004016 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004017 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004018 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004019 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004020 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004021 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004022 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004023 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004024 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004025 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 195103004026 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 195103004027 GGGtGRT protein; Region: GGGtGRT; pfam14057 195103004028 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 195103004029 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 195103004030 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 195103004031 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 195103004032 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004033 sugar binding site [chemical binding]; other site 195103004034 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cd08523 195103004035 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103004036 Interdomain contacts; other site 195103004037 Cytokine receptor motif; other site 195103004038 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 195103004039 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 195103004040 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 195103004041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103004042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195103004043 putative substrate translocation pore; other site 195103004044 MgtE intracellular N domain; Region: MgtE_N; pfam03448 195103004045 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 195103004046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 195103004047 Divalent cation transporter; Region: MgtE; pfam01769 195103004048 Uncharacterized conserved protein [Function unknown]; Region: COG1434 195103004049 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 195103004050 putative active site [active] 195103004051 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 195103004052 DNA-binding site [nucleotide binding]; DNA binding site 195103004053 RNA-binding motif; other site 195103004054 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 195103004055 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 195103004056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 195103004057 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 195103004058 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 195103004059 Predicted integral membrane protein [Function unknown]; Region: COG0392 195103004060 Uncharacterized conserved protein [Function unknown]; Region: COG2898 195103004061 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 195103004062 Predicted integral membrane protein [Function unknown]; Region: COG0392 195103004063 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 195103004064 Bax inhibitor 1 like; Region: BaxI_1; cl17691 195103004065 putative oxidoreductase; Provisional; Region: PRK12831 195103004066 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195103004067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 195103004068 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 195103004069 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 195103004070 FAD binding pocket [chemical binding]; other site 195103004071 FAD binding motif [chemical binding]; other site 195103004072 phosphate binding motif [ion binding]; other site 195103004073 beta-alpha-beta structure motif; other site 195103004074 NAD binding pocket [chemical binding]; other site 195103004075 Iron coordination center [ion binding]; other site 195103004076 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 195103004077 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 195103004078 putative active site [active] 195103004079 metal binding site [ion binding]; metal-binding site 195103004080 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 195103004081 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 195103004082 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004083 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004084 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004085 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004086 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004087 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004088 HNH endonuclease; Region: HNH_2; pfam13391 195103004089 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 195103004090 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 195103004091 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 195103004092 transcription elongation factor GreA; Region: greA; TIGR01462 195103004093 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 195103004094 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004095 sugar binding site [chemical binding]; other site 195103004096 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 195103004097 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004098 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103004099 Interdomain contacts; other site 195103004100 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 195103004101 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 195103004102 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 195103004103 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 195103004104 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 195103004105 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 195103004106 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 195103004107 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 195103004108 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 195103004109 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 195103004110 active site 195103004111 putative substrate binding pocket [chemical binding]; other site 195103004112 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 195103004113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 195103004114 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 195103004115 active site 195103004116 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 195103004117 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 195103004118 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 195103004119 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 195103004120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103004121 Walker A/P-loop; other site 195103004122 ATP binding site [chemical binding]; other site 195103004123 Q-loop/lid; other site 195103004124 ABC transporter signature motif; other site 195103004125 Walker B; other site 195103004126 D-loop; other site 195103004127 H-loop/switch region; other site 195103004128 TOBE domain; Region: TOBE_2; pfam08402 195103004129 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 195103004130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103004131 dimer interface [polypeptide binding]; other site 195103004132 conserved gate region; other site 195103004133 putative PBP binding loops; other site 195103004134 ABC-ATPase subunit interface; other site 195103004135 sulfate transport protein; Provisional; Region: cysT; CHL00187 195103004136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103004137 dimer interface [polypeptide binding]; other site 195103004138 conserved gate region; other site 195103004139 putative PBP binding loops; other site 195103004140 ABC-ATPase subunit interface; other site 195103004141 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 195103004142 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 195103004143 FMN binding site [chemical binding]; other site 195103004144 active site 195103004145 catalytic residues [active] 195103004146 substrate binding site [chemical binding]; other site 195103004147 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103004148 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 195103004149 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 195103004150 OPT oligopeptide transporter protein; Region: OPT; pfam03169 195103004151 putative oligopeptide transporter, OPT family; Region: TIGR00733 195103004152 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 195103004153 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004154 CD99 antigen like protein 2; Region: CD99L2; pfam12301 195103004155 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 195103004156 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004157 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004158 Peptidase M60-like family; Region: M60-like; pfam13402 195103004159 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 195103004160 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 195103004161 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 195103004162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103004163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195103004164 putative substrate translocation pore; other site 195103004165 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 195103004166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103004167 DNA-binding site [nucleotide binding]; DNA binding site 195103004168 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 195103004169 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 195103004170 Nucleoside recognition; Region: Gate; pfam07670 195103004171 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 195103004172 Predicted membrane protein [Function unknown]; Region: COG1289 195103004173 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 195103004174 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 195103004175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103004176 putative DNA binding site [nucleotide binding]; other site 195103004177 putative Zn2+ binding site [ion binding]; other site 195103004178 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 195103004179 Active site serine [active] 195103004180 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 195103004181 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 195103004182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103004183 ATP binding site [chemical binding]; other site 195103004184 Mg2+ binding site [ion binding]; other site 195103004185 G-X-G motif; other site 195103004186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103004187 active site 195103004188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103004189 binding surface 195103004190 TPR motif; other site 195103004191 TPR repeat; Region: TPR_11; pfam13414 195103004192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103004193 binding surface 195103004194 TPR motif; other site 195103004195 TPR repeat; Region: TPR_11; pfam13414 195103004196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103004197 binding surface 195103004198 TPR motif; other site 195103004199 TPR repeat; Region: TPR_11; pfam13414 195103004200 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 195103004201 SmpB-tmRNA interface; other site 195103004202 ribonuclease R; Region: RNase_R; TIGR02063 195103004203 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 195103004204 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 195103004205 RNB domain; Region: RNB; pfam00773 195103004206 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 195103004207 RNA binding site [nucleotide binding]; other site 195103004208 Preprotein translocase SecG subunit; Region: SecG; pfam03840 195103004209 enolase; Provisional; Region: eno; PRK00077 195103004210 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 195103004211 dimer interface [polypeptide binding]; other site 195103004212 metal binding site [ion binding]; metal-binding site 195103004213 substrate binding pocket [chemical binding]; other site 195103004214 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 195103004215 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 195103004216 phosphoglyceromutase; Provisional; Region: PRK05434 195103004217 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 195103004218 triosephosphate isomerase; Provisional; Region: PRK14567 195103004219 substrate binding site [chemical binding]; other site 195103004220 dimer interface [polypeptide binding]; other site 195103004221 catalytic triad [active] 195103004222 Phosphoglycerate kinase; Region: PGK; pfam00162 195103004223 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 195103004224 substrate binding site [chemical binding]; other site 195103004225 hinge regions; other site 195103004226 ADP binding site [chemical binding]; other site 195103004227 catalytic site [active] 195103004228 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 195103004229 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 195103004230 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 195103004231 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 195103004232 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 195103004233 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 195103004234 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 195103004235 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 195103004236 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 195103004237 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 195103004238 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 195103004239 ligand binding site [chemical binding]; other site 195103004240 EDD domain protein, DegV family; Region: DegV; TIGR00762 195103004241 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 195103004242 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 195103004243 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 195103004244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103004245 active site 195103004246 motif I; other site 195103004247 motif II; other site 195103004248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103004249 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 195103004250 VanW like protein; Region: VanW; pfam04294 195103004251 G5 domain; Region: G5; pfam07501 195103004252 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 195103004253 active site 195103004254 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 195103004255 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 195103004256 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 195103004257 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195103004258 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 195103004259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195103004260 putative active site [active] 195103004261 heme pocket [chemical binding]; other site 195103004262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103004263 dimer interface [polypeptide binding]; other site 195103004264 phosphorylation site [posttranslational modification] 195103004265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103004266 ATP binding site [chemical binding]; other site 195103004267 Mg2+ binding site [ion binding]; other site 195103004268 G-X-G motif; other site 195103004269 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 195103004270 EamA-like transporter family; Region: EamA; pfam00892 195103004271 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 195103004272 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 195103004273 minor groove reading motif; other site 195103004274 helix-hairpin-helix signature motif; other site 195103004275 substrate binding pocket [chemical binding]; other site 195103004276 active site 195103004277 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 195103004278 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 195103004279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 195103004280 putative acyl-acceptor binding pocket; other site 195103004281 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 195103004282 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 195103004283 serine O-acetyltransferase; Region: cysE; TIGR01172 195103004284 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 195103004285 trimer interface [polypeptide binding]; other site 195103004286 active site 195103004287 substrate binding site [chemical binding]; other site 195103004288 CoA binding site [chemical binding]; other site 195103004289 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 195103004290 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 195103004291 dimer interface [polypeptide binding]; other site 195103004292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103004293 catalytic residue [active] 195103004294 PRC-barrel domain; Region: PRC; pfam05239 195103004295 MgtE intracellular N domain; Region: MgtE_N; smart00924 195103004296 FOG: CBS domain [General function prediction only]; Region: COG0517 195103004297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 195103004298 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 195103004299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195103004300 substrate binding pocket [chemical binding]; other site 195103004301 membrane-bound complex binding site; other site 195103004302 hinge residues; other site 195103004303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103004304 dimer interface [polypeptide binding]; other site 195103004305 conserved gate region; other site 195103004306 putative PBP binding loops; other site 195103004307 ABC-ATPase subunit interface; other site 195103004308 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 195103004309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103004310 Walker A/P-loop; other site 195103004311 ATP binding site [chemical binding]; other site 195103004312 Q-loop/lid; other site 195103004313 ABC transporter signature motif; other site 195103004314 Walker B; other site 195103004315 D-loop; other site 195103004316 H-loop/switch region; other site 195103004317 putative lipid kinase; Reviewed; Region: PRK13059 195103004318 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 195103004319 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 195103004320 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 195103004321 Domain of Unknown Function (DUF1041); Region: DUF1041; pfam06292 195103004322 Rubrerythrin [Energy production and conversion]; Region: COG1592 195103004323 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 195103004324 binuclear metal center [ion binding]; other site 195103004325 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103004326 iron binding site [ion binding]; other site 195103004327 SpoVR like protein; Region: SpoVR; pfam04293 195103004328 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 195103004329 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 195103004330 metal ion-dependent adhesion site (MIDAS); other site 195103004331 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 195103004332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 195103004333 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 195103004334 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 195103004335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103004336 ATP binding site [chemical binding]; other site 195103004337 putative Mg++ binding site [ion binding]; other site 195103004338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103004339 nucleotide binding region [chemical binding]; other site 195103004340 ATP-binding site [chemical binding]; other site 195103004341 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 195103004342 HRDC domain; Region: HRDC; pfam00570 195103004343 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 195103004344 thiamine phosphate binding site [chemical binding]; other site 195103004345 active site 195103004346 pyrophosphate binding site [ion binding]; other site 195103004347 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 195103004348 substrate binding site [chemical binding]; other site 195103004349 multimerization interface [polypeptide binding]; other site 195103004350 ATP binding site [chemical binding]; other site 195103004351 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 195103004352 dimer interface [polypeptide binding]; other site 195103004353 substrate binding site [chemical binding]; other site 195103004354 ATP binding site [chemical binding]; other site 195103004355 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 195103004356 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 195103004357 active site 195103004358 nucleophile elbow; other site 195103004359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103004360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103004361 DNA binding site [nucleotide binding] 195103004362 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 195103004363 putative dimerization interface [polypeptide binding]; other site 195103004364 putative ligand binding site [chemical binding]; other site 195103004365 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 195103004366 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 195103004367 ligand binding site [chemical binding]; other site 195103004368 calcium binding site [ion binding]; other site 195103004369 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 195103004370 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 195103004371 Walker A/P-loop; other site 195103004372 ATP binding site [chemical binding]; other site 195103004373 Q-loop/lid; other site 195103004374 ABC transporter signature motif; other site 195103004375 Walker B; other site 195103004376 D-loop; other site 195103004377 H-loop/switch region; other site 195103004378 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 195103004379 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 195103004380 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 195103004381 TM-ABC transporter signature motif; other site 195103004382 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 195103004383 active site 195103004384 catalytic residues [active] 195103004385 galactokinase; Provisional; Region: PRK05322 195103004386 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 195103004387 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 195103004388 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 195103004389 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 195103004390 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 195103004391 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 195103004392 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 195103004393 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 195103004394 active site 195103004395 Predicted membrane protein [Function unknown]; Region: COG2323 195103004396 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 195103004397 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 195103004398 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 195103004399 intersubunit interface [polypeptide binding]; other site 195103004400 active site 195103004401 zinc binding site [ion binding]; other site 195103004402 Na+ binding site [ion binding]; other site 195103004403 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 195103004404 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 195103004405 putative active site [active] 195103004406 putative metal binding residues [ion binding]; other site 195103004407 putative triphosphate binding site [ion binding]; other site 195103004408 signature motif; other site 195103004409 dimer interface [polypeptide binding]; other site 195103004410 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004411 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004412 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004413 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 195103004414 NlpC/P60 family; Region: NLPC_P60; pfam00877 195103004415 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 195103004416 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 195103004417 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 195103004418 putative deacylase active site [active] 195103004419 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 195103004420 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 195103004421 active site 195103004422 Bacterial SH3 domain; Region: SH3_3; pfam08239 195103004423 Bacterial SH3 domain homologues; Region: SH3b; smart00287 195103004424 Haemolysin XhlA; Region: XhlA; pfam10779 195103004425 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 195103004426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 195103004427 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 195103004428 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 195103004429 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195103004430 Peptidase family M23; Region: Peptidase_M23; pfam01551 195103004431 Phage-related protein [Function unknown]; Region: COG4722 195103004432 Phage tail protein; Region: Sipho_tail; cl17486 195103004433 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 195103004434 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 195103004435 Phage-related protein [Function unknown]; Region: COG5412 195103004436 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 195103004437 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 195103004438 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 195103004439 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 195103004440 oligomerization interface [polypeptide binding]; other site 195103004441 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 195103004442 Phage capsid family; Region: Phage_capsid; pfam05065 195103004443 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 195103004444 Phage portal protein; Region: Phage_portal; pfam04860 195103004445 Phage-related protein [Function unknown]; Region: COG4695; cl01923 195103004446 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 195103004447 Phage terminase, small subunit; Region: Terminase_4; pfam05119 195103004448 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 195103004449 Int/Topo IB signature motif; other site 195103004450 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 195103004451 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 195103004452 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 195103004453 dimer interface [polypeptide binding]; other site 195103004454 ssDNA binding site [nucleotide binding]; other site 195103004455 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195103004456 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 195103004457 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 195103004458 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 195103004459 Walker A motif; other site 195103004460 ATP binding site [chemical binding]; other site 195103004461 Walker B motif; other site 195103004462 DNA binding loops [nucleotide binding] 195103004463 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 195103004464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103004465 non-specific DNA binding site [nucleotide binding]; other site 195103004466 salt bridge; other site 195103004467 sequence-specific DNA binding site [nucleotide binding]; other site 195103004468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 195103004469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103004470 non-specific DNA binding site [nucleotide binding]; other site 195103004471 salt bridge; other site 195103004472 sequence-specific DNA binding site [nucleotide binding]; other site 195103004473 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 195103004474 Domain of unknown function (DUF955); Region: DUF955; pfam06114 195103004475 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 195103004476 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 195103004477 catalytic residues [active] 195103004478 catalytic nucleophile [active] 195103004479 Presynaptic Site I dimer interface [polypeptide binding]; other site 195103004480 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 195103004481 Synaptic Flat tetramer interface [polypeptide binding]; other site 195103004482 Synaptic Site I dimer interface [polypeptide binding]; other site 195103004483 DNA binding site [nucleotide binding] 195103004484 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 195103004485 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 195103004486 putative deacylase active site [active] 195103004487 hypothetical protein; Provisional; Region: PRK01184 195103004488 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 195103004489 ribonuclease Z; Region: RNase_Z; TIGR02651 195103004490 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004491 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004492 sugar binding site [chemical binding]; other site 195103004493 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 195103004494 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 195103004495 active site 195103004496 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 195103004497 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004498 sugar binding site [chemical binding]; other site 195103004499 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 195103004500 dockerin binding interface; other site 195103004501 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103004502 Interdomain contacts; other site 195103004503 Cytokine receptor motif; other site 195103004504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103004505 DNA-binding site [nucleotide binding]; DNA binding site 195103004506 TrkA-C domain; Region: TrkA_C; pfam02080 195103004507 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 195103004508 G4 box; other site 195103004509 G5 box; other site 195103004510 YibE/F-like protein; Region: YibE_F; pfam07907 195103004511 Lamin Tail Domain; Region: LTD; pfam00932 195103004512 OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336 195103004513 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 195103004514 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 195103004515 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 195103004516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103004517 Coenzyme A binding pocket [chemical binding]; other site 195103004518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 195103004519 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 195103004520 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 195103004521 active site 195103004522 dimer interface [polypeptide binding]; other site 195103004523 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 195103004524 Na2 binding site [ion binding]; other site 195103004525 putative substrate binding site 1 [chemical binding]; other site 195103004526 Na binding site 1 [ion binding]; other site 195103004527 putative substrate binding site 2 [chemical binding]; other site 195103004528 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 195103004529 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 195103004530 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 195103004531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103004532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103004533 homodimer interface [polypeptide binding]; other site 195103004534 catalytic residue [active] 195103004535 calcium/proton exchanger (cax); Region: cax; TIGR00378 195103004536 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 195103004537 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 195103004538 Uncharacterized conserved protein [Function unknown]; Region: COG3379 195103004539 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 195103004540 Domain of unknown function (DUF368); Region: DUF368; pfam04018 195103004541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 195103004542 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 195103004543 Probable transposase; Region: OrfB_IS605; pfam01385 195103004544 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 195103004545 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 195103004546 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 195103004547 methionine aminopeptidase; Provisional; Region: PRK12318 195103004548 SEC-C motif; Region: SEC-C; pfam02810 195103004549 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 195103004550 active site 195103004551 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 195103004552 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 195103004553 G1 box; other site 195103004554 GTP/Mg2+ binding site [chemical binding]; other site 195103004555 Switch I region; other site 195103004556 G2 box; other site 195103004557 G3 box; other site 195103004558 Switch II region; other site 195103004559 G4 box; other site 195103004560 G5 box; other site 195103004561 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 195103004562 Found in ATP-dependent protease La (LON); Region: LON; smart00464 195103004563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103004564 Walker A motif; other site 195103004565 ATP binding site [chemical binding]; other site 195103004566 Walker B motif; other site 195103004567 arginine finger; other site 195103004568 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 195103004569 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 195103004570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103004571 Walker A motif; other site 195103004572 ATP binding site [chemical binding]; other site 195103004573 Walker B motif; other site 195103004574 arginine finger; other site 195103004575 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 195103004576 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 195103004577 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 195103004578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103004579 Walker A motif; other site 195103004580 ATP binding site [chemical binding]; other site 195103004581 Walker B motif; other site 195103004582 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 195103004583 Clp protease; Region: CLP_protease; pfam00574 195103004584 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 195103004585 oligomer interface [polypeptide binding]; other site 195103004586 active site residues [active] 195103004587 trigger factor; Provisional; Region: tig; PRK01490 195103004588 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 195103004589 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 195103004590 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 195103004591 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 195103004592 AP (apurinic/apyrimidinic) site pocket; other site 195103004593 DNA interaction; other site 195103004594 Metal-binding active site; metal-binding site 195103004595 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 195103004596 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 195103004597 ATP binding site [chemical binding]; other site 195103004598 Mg++ binding site [ion binding]; other site 195103004599 motif III; other site 195103004600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103004601 nucleotide binding region [chemical binding]; other site 195103004602 ATP-binding site [chemical binding]; other site 195103004603 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 195103004604 RNA binding site [nucleotide binding]; other site 195103004605 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 195103004606 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 195103004607 Predicted membrane protein [Function unknown]; Region: COG4640 195103004608 PEGA domain; Region: PEGA; pfam08308 195103004609 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 195103004610 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 195103004611 active site 195103004612 catalytic site [active] 195103004613 substrate binding site [chemical binding]; other site 195103004614 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 195103004615 Dimer interface [polypeptide binding]; other site 195103004616 BRCT sequence motif; other site 195103004617 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 195103004618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 195103004619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 195103004620 Peptidase M16C associated; Region: M16C_assoc; pfam08367 195103004621 Putative amidase domain; Region: Amidase_6; pfam12671 195103004622 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 195103004623 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 195103004624 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 195103004625 Cl- selectivity filter; other site 195103004626 Cl- binding residues [ion binding]; other site 195103004627 pore gating glutamate residue; other site 195103004628 dimer interface [polypeptide binding]; other site 195103004629 H+/Cl- coupling transport residue; other site 195103004630 TrkA-C domain; Region: TrkA_C; pfam02080 195103004631 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 195103004632 SLBB domain; Region: SLBB; pfam10531 195103004633 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195103004634 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 195103004635 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 195103004636 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 195103004637 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 195103004638 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 195103004639 Ligand Binding Site [chemical binding]; other site 195103004640 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 195103004641 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 195103004642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103004643 catalytic residue [active] 195103004644 hypothetical protein; Provisional; Region: PRK04435 195103004645 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 195103004646 DNA-binding interface [nucleotide binding]; DNA binding site 195103004647 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 195103004648 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 195103004649 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 195103004650 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 195103004651 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 195103004652 putative acyl-acceptor binding pocket; other site 195103004653 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 195103004654 amino acid carrier protein; Region: agcS; TIGR00835 195103004655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103004656 Zn2+ binding site [ion binding]; other site 195103004657 Mg2+ binding site [ion binding]; other site 195103004658 Predicted membrane protein [Function unknown]; Region: COG4684 195103004659 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 195103004660 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 195103004661 putative active site pocket [active] 195103004662 cleavage site 195103004663 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 195103004664 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 195103004665 putative active site pocket [active] 195103004666 dimerization interface [polypeptide binding]; other site 195103004667 putative catalytic residue [active] 195103004668 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 195103004669 putative substrate binding pocket [chemical binding]; other site 195103004670 AC domain interface; other site 195103004671 catalytic triad [active] 195103004672 AB domain interface; other site 195103004673 interchain disulfide; other site 195103004674 Predicted membrane protein [Function unknown]; Region: COG3817 195103004675 Protein of unknown function (DUF979); Region: DUF979; pfam06166 195103004676 Protein of unknown function (DUF969); Region: DUF969; pfam06149 195103004677 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 195103004678 Clp amino terminal domain; Region: Clp_N; pfam02861 195103004679 Clp amino terminal domain; Region: Clp_N; pfam02861 195103004680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103004681 Walker A motif; other site 195103004682 ATP binding site [chemical binding]; other site 195103004683 Walker B motif; other site 195103004684 arginine finger; other site 195103004685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103004686 Walker A motif; other site 195103004687 ATP binding site [chemical binding]; other site 195103004688 Walker B motif; other site 195103004689 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 195103004690 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 195103004691 synthetase active site [active] 195103004692 NTP binding site [chemical binding]; other site 195103004693 metal binding site [ion binding]; metal-binding site 195103004694 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 195103004695 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 195103004696 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 195103004697 putative active site [active] 195103004698 catalytic site [active] 195103004699 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 195103004700 putative active site [active] 195103004701 catalytic site [active] 195103004702 L-aspartate oxidase; Region: nadB; TIGR00551 195103004703 L-aspartate oxidase; Provisional; Region: PRK06175 195103004704 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 195103004705 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 195103004706 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 195103004707 inhibitor-cofactor binding pocket; inhibition site 195103004708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103004709 catalytic residue [active] 195103004710 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 195103004711 dimer interface [polypeptide binding]; other site 195103004712 active site 195103004713 Schiff base residues; other site 195103004714 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 195103004715 active site 195103004716 SAM binding site [chemical binding]; other site 195103004717 homodimer interface [polypeptide binding]; other site 195103004718 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 195103004719 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 195103004720 active site 195103004721 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 195103004722 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 195103004723 domain interfaces; other site 195103004724 active site 195103004725 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 195103004726 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 195103004727 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 195103004728 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 195103004729 NAD(P) binding pocket [chemical binding]; other site 195103004730 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 195103004731 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 195103004732 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 195103004733 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195103004734 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 195103004735 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 195103004736 FAD binding pocket [chemical binding]; other site 195103004737 FAD binding motif [chemical binding]; other site 195103004738 phosphate binding motif [ion binding]; other site 195103004739 beta-alpha-beta structure motif; other site 195103004740 NAD binding pocket [chemical binding]; other site 195103004741 Iron coordination center [ion binding]; other site 195103004742 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 195103004743 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 195103004744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195103004745 ligand binding site [chemical binding]; other site 195103004746 flexible hinge region; other site 195103004747 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 195103004748 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 195103004749 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 195103004750 GIY-YIG motif/motif A; other site 195103004751 putative active site [active] 195103004752 putative metal binding site [ion binding]; other site 195103004753 Cupin domain; Region: Cupin_2; pfam07883 195103004754 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103004755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103004756 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 195103004757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103004758 non-specific DNA binding site [nucleotide binding]; other site 195103004759 salt bridge; other site 195103004760 sequence-specific DNA binding site [nucleotide binding]; other site 195103004761 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 195103004762 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 195103004763 RNA/DNA hybrid binding site [nucleotide binding]; other site 195103004764 active site 195103004765 Uncharacterized conserved protein [Function unknown]; Region: COG3339 195103004766 Rhomboid family; Region: Rhomboid; pfam01694 195103004767 oligoendopeptidase F; Region: pepF; TIGR00181 195103004768 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 195103004769 active site 195103004770 Zn binding site [ion binding]; other site 195103004771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 195103004772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103004773 Walker A/P-loop; other site 195103004774 ATP binding site [chemical binding]; other site 195103004775 Q-loop/lid; other site 195103004776 ABC transporter signature motif; other site 195103004777 Walker B; other site 195103004778 D-loop; other site 195103004779 H-loop/switch region; other site 195103004780 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 195103004781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 195103004782 ABC-ATPase subunit interface; other site 195103004783 dimer interface [polypeptide binding]; other site 195103004784 putative PBP binding regions; other site 195103004785 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103004786 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 195103004787 Fn3 associated; Region: Fn3_assoc; pfam13287 195103004788 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103004789 ferric uptake regulator; Provisional; Region: fur; PRK09462 195103004790 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 195103004791 metal binding site 2 [ion binding]; metal-binding site 195103004792 putative DNA binding helix; other site 195103004793 metal binding site 1 [ion binding]; metal-binding site 195103004794 dimer interface [polypeptide binding]; other site 195103004795 structural Zn2+ binding site [ion binding]; other site 195103004796 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 195103004797 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 195103004798 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 195103004799 active site 195103004800 phosphorylation site [posttranslational modification] 195103004801 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 195103004802 active pocket/dimerization site; other site 195103004803 active site 195103004804 phosphorylation site [posttranslational modification] 195103004805 6-phosphofructokinase; Provisional; Region: PRK14072 195103004806 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 195103004807 active site 195103004808 ADP/pyrophosphate binding site [chemical binding]; other site 195103004809 dimerization interface [polypeptide binding]; other site 195103004810 allosteric effector site; other site 195103004811 fructose-1,6-bisphosphate binding site; other site 195103004812 C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909 195103004813 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 195103004814 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 195103004815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103004816 catalytic residue [active] 195103004817 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 195103004818 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103004819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103004820 ABC transporter; Region: ABC_tran_2; pfam12848 195103004821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103004822 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 195103004823 trimer interface [polypeptide binding]; other site 195103004824 active site 195103004825 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 195103004826 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 195103004827 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 195103004828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 195103004829 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 195103004830 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 195103004831 putative dimerization interface [polypeptide binding]; other site 195103004832 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 195103004833 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 195103004834 NodB motif; other site 195103004835 active site 195103004836 catalytic site [active] 195103004837 Zn binding site [ion binding]; other site 195103004838 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 195103004839 active site 195103004840 putative transporter; Provisional; Region: PRK11660 195103004841 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 195103004842 Sulfate transporter family; Region: Sulfate_transp; pfam00916 195103004843 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 195103004844 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 195103004845 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 195103004846 substrate binding site [chemical binding]; other site 195103004847 ATP binding site [chemical binding]; other site 195103004848 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 195103004849 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 195103004850 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 195103004851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103004852 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195103004853 Walker A/P-loop; other site 195103004854 ATP binding site [chemical binding]; other site 195103004855 Q-loop/lid; other site 195103004856 ABC transporter signature motif; other site 195103004857 Walker B; other site 195103004858 D-loop; other site 195103004859 H-loop/switch region; other site 195103004860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103004861 dimer interface [polypeptide binding]; other site 195103004862 conserved gate region; other site 195103004863 putative PBP binding loops; other site 195103004864 ABC-ATPase subunit interface; other site 195103004865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 195103004866 NMT1/THI5 like; Region: NMT1; pfam09084 195103004867 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 195103004868 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195103004869 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 195103004870 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 195103004871 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103004872 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 195103004873 Ligand Binding Site [chemical binding]; other site 195103004874 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 195103004875 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 195103004876 QueT transporter; Region: QueT; pfam06177 195103004877 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 195103004878 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 195103004879 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 195103004880 ATP binding site [chemical binding]; other site 195103004881 Mg2+ binding site [ion binding]; other site 195103004882 G-X-G motif; other site 195103004883 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 195103004884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103004885 active site 195103004886 phosphorylation site [posttranslational modification] 195103004887 intermolecular recognition site; other site 195103004888 dimerization interface [polypeptide binding]; other site 195103004889 LytTr DNA-binding domain; Region: LytTR; pfam04397 195103004890 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 195103004891 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 195103004892 active site 195103004893 metal binding site [ion binding]; metal-binding site 195103004894 Domain of unknown function DUF77; Region: DUF77; pfam01910 195103004895 Domain of unknown function (DUF348); Region: DUF348; pfam03990 195103004896 Domain of unknown function (DUF348); Region: DUF348; pfam03990 195103004897 G5 domain; Region: G5; pfam07501 195103004898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 195103004899 uracil transporter; Provisional; Region: PRK10720 195103004900 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 195103004901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103004902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103004903 ABC transporter; Region: ABC_tran_2; pfam12848 195103004904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103004905 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 195103004906 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 195103004907 NodB motif; other site 195103004908 active site 195103004909 catalytic site [active] 195103004910 Zn binding site [ion binding]; other site 195103004911 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 195103004912 BNR repeat-like domain; Region: BNR_2; pfam13088 195103004913 DNA topoisomerase III; Provisional; Region: PRK07726 195103004914 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 195103004915 active site 195103004916 putative interdomain interaction site [polypeptide binding]; other site 195103004917 putative metal-binding site [ion binding]; other site 195103004918 putative nucleotide binding site [chemical binding]; other site 195103004919 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 195103004920 domain I; other site 195103004921 DNA binding groove [nucleotide binding] 195103004922 phosphate binding site [ion binding]; other site 195103004923 domain II; other site 195103004924 domain III; other site 195103004925 nucleotide binding site [chemical binding]; other site 195103004926 catalytic site [active] 195103004927 domain IV; other site 195103004928 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 195103004929 Predicted membrane protein [Function unknown]; Region: COG3428 195103004930 Bacterial PH domain; Region: DUF304; pfam03703 195103004931 Bacterial PH domain; Region: DUF304; pfam03703 195103004932 Bacterial PH domain; Region: DUF304; pfam03703 195103004933 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 195103004934 Two component regulator propeller; Region: Reg_prop; pfam07494 195103004935 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 195103004936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103004937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103004938 dimer interface [polypeptide binding]; other site 195103004939 phosphorylation site [posttranslational modification] 195103004940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103004941 ATP binding site [chemical binding]; other site 195103004942 Mg2+ binding site [ion binding]; other site 195103004943 G-X-G motif; other site 195103004944 DHHW protein; Region: DHHW; pfam14286 195103004945 DHHW protein; Region: DHHW; pfam14286 195103004946 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 195103004947 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 195103004948 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 195103004949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 195103004950 ATP binding site [chemical binding]; other site 195103004951 putative Mg++ binding site [ion binding]; other site 195103004952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103004953 nucleotide binding region [chemical binding]; other site 195103004954 ATP-binding site [chemical binding]; other site 195103004955 glutamate dehydrogenase; Provisional; Region: PRK09414 195103004956 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 195103004957 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 195103004958 NAD(P) binding site [chemical binding]; other site 195103004959 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 195103004960 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 195103004961 homodimer interface [polypeptide binding]; other site 195103004962 substrate-cofactor binding pocket; other site 195103004963 catalytic residue [active] 195103004964 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 195103004965 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103004966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103004967 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 195103004968 Walker A/P-loop; other site 195103004969 ATP binding site [chemical binding]; other site 195103004970 Q-loop/lid; other site 195103004971 ABC transporter signature motif; other site 195103004972 Walker B; other site 195103004973 D-loop; other site 195103004974 H-loop/switch region; other site 195103004975 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103004976 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103004977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103004978 Walker A/P-loop; other site 195103004979 ATP binding site [chemical binding]; other site 195103004980 Q-loop/lid; other site 195103004981 ABC transporter signature motif; other site 195103004982 Walker B; other site 195103004983 D-loop; other site 195103004984 H-loop/switch region; other site 195103004985 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 195103004986 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 195103004987 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 195103004988 NodB motif; other site 195103004989 putative active site [active] 195103004990 putative catalytic site [active] 195103004991 putative Zn binding site [ion binding]; other site 195103004992 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 195103004993 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 195103004994 putative substrate binding site [chemical binding]; other site 195103004995 putative ATP binding site [chemical binding]; other site 195103004996 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 195103004997 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 195103004998 substrate binding [chemical binding]; other site 195103004999 active site 195103005000 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 195103005001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103005002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103005003 DNA binding site [nucleotide binding] 195103005004 domain linker motif; other site 195103005005 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 195103005006 dimerization interface [polypeptide binding]; other site 195103005007 ligand binding site [chemical binding]; other site 195103005008 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 195103005009 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 195103005010 active site turn [active] 195103005011 phosphorylation site [posttranslational modification] 195103005012 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 195103005013 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 195103005014 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 195103005015 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 195103005016 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 195103005017 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 195103005018 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 195103005019 FAD binding pocket [chemical binding]; other site 195103005020 FAD binding motif [chemical binding]; other site 195103005021 phosphate binding motif [ion binding]; other site 195103005022 beta-alpha-beta structure motif; other site 195103005023 NAD binding pocket [chemical binding]; other site 195103005024 Iron coordination center [ion binding]; other site 195103005025 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 195103005026 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195103005027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 195103005028 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 195103005029 FtsX-like permease family; Region: FtsX; pfam02687 195103005030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 195103005031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 195103005032 Walker A/P-loop; other site 195103005033 ATP binding site [chemical binding]; other site 195103005034 Q-loop/lid; other site 195103005035 ABC transporter signature motif; other site 195103005036 Walker B; other site 195103005037 D-loop; other site 195103005038 H-loop/switch region; other site 195103005039 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 195103005040 HlyD family secretion protein; Region: HlyD_3; pfam13437 195103005041 AAA domain; Region: AAA_26; pfam13500 195103005042 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 195103005043 biotin synthase; Region: bioB; TIGR00433 195103005044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103005045 FeS/SAM binding site; other site 195103005046 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 195103005047 Predicted secreted protein [Function unknown]; Region: COG4086 195103005048 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 195103005049 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 195103005050 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 195103005051 putative [4Fe-4S] binding site [ion binding]; other site 195103005052 putative molybdopterin cofactor binding site [chemical binding]; other site 195103005053 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 195103005054 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 195103005055 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 195103005056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103005057 active site 195103005058 hypothetical protein; Provisional; Region: PRK06851 195103005059 AAA domain; Region: AAA_30; pfam13604 195103005060 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 195103005061 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 195103005062 NodB motif; other site 195103005063 active site 195103005064 catalytic site [active] 195103005065 Zn binding site [ion binding]; other site 195103005066 pullulanase, type I; Region: pulA_typeI; TIGR02104 195103005067 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 195103005068 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 195103005069 Ca binding site [ion binding]; other site 195103005070 active site 195103005071 catalytic site [active] 195103005072 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 195103005073 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 195103005074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 195103005075 Catalytic site [active] 195103005076 ATP cone domain; Region: ATP-cone; pfam03477 195103005077 Sulfatase; Region: Sulfatase; pfam00884 195103005078 Predicted membrane protein [Function unknown]; Region: COG4129 195103005079 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 195103005080 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 195103005081 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 195103005082 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 195103005083 catalytic residue [active] 195103005084 putative FPP diphosphate binding site; other site 195103005085 putative FPP binding hydrophobic cleft; other site 195103005086 dimer interface [polypeptide binding]; other site 195103005087 putative IPP diphosphate binding site; other site 195103005088 phytoene desaturase; Region: crtI_fam; TIGR02734 195103005089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 195103005090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 195103005091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195103005092 metal binding site [ion binding]; metal-binding site 195103005093 active site 195103005094 I-site; other site 195103005095 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 195103005096 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103005097 Zn2+ binding site [ion binding]; other site 195103005098 Mg2+ binding site [ion binding]; other site 195103005099 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 195103005100 Accessory gene regulator B; Region: AgrB; smart00793 195103005101 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103005102 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 195103005103 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 195103005104 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 195103005105 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 195103005106 active site 195103005107 DNA polymerase IV; Validated; Region: PRK02406 195103005108 DNA binding site [nucleotide binding] 195103005109 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 195103005110 active site 195103005111 Protein of unknown function (DUF3785); Region: DUF3785; pfam12653 195103005112 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 195103005113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103005114 active site 195103005115 motif I; other site 195103005116 motif II; other site 195103005117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103005118 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 195103005119 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 195103005120 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 195103005121 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195103005122 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 195103005123 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 195103005124 nucleophile elbow; other site 195103005125 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 195103005126 CoA binding domain; Region: CoA_binding_2; pfam13380 195103005127 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 195103005128 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 195103005129 TM-ABC transporter signature motif; other site 195103005130 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 195103005131 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 195103005132 TM-ABC transporter signature motif; other site 195103005133 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 195103005134 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 195103005135 Walker A/P-loop; other site 195103005136 ATP binding site [chemical binding]; other site 195103005137 Q-loop/lid; other site 195103005138 ABC transporter signature motif; other site 195103005139 Walker B; other site 195103005140 D-loop; other site 195103005141 H-loop/switch region; other site 195103005142 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 195103005143 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 195103005144 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 195103005145 ligand binding site [chemical binding]; other site 195103005146 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 195103005147 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 195103005148 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 195103005149 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 195103005150 Walker A/P-loop; other site 195103005151 ATP binding site [chemical binding]; other site 195103005152 Q-loop/lid; other site 195103005153 ABC transporter signature motif; other site 195103005154 Walker B; other site 195103005155 D-loop; other site 195103005156 H-loop/switch region; other site 195103005157 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 195103005158 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 195103005159 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 195103005160 Walker A/P-loop; other site 195103005161 ATP binding site [chemical binding]; other site 195103005162 Q-loop/lid; other site 195103005163 ABC transporter signature motif; other site 195103005164 Walker B; other site 195103005165 D-loop; other site 195103005166 H-loop/switch region; other site 195103005167 hypothetical protein; Provisional; Region: PRK13661 195103005168 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 195103005169 active site residue [active] 195103005170 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 195103005171 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 195103005172 pullulanase, type I; Region: pulA_typeI; TIGR02104 195103005173 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 195103005174 Ca binding site [ion binding]; other site 195103005175 active site 195103005176 catalytic site [active] 195103005177 glycogen branching enzyme; Provisional; Region: PRK12313 195103005178 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 195103005179 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 195103005180 active site 195103005181 catalytic site [active] 195103005182 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 195103005183 Uncharacterized conserved protein [Function unknown]; Region: COG2966 195103005184 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 195103005185 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 195103005186 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 195103005187 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 195103005188 catalytic residues [active] 195103005189 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 195103005190 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 195103005191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 195103005192 CAAX protease self-immunity; Region: Abi; pfam02517 195103005193 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 195103005194 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 195103005195 thiamine phosphate binding site [chemical binding]; other site 195103005196 active site 195103005197 pyrophosphate binding site [ion binding]; other site 195103005198 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 195103005199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103005200 FeS/SAM binding site; other site 195103005201 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 195103005202 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 195103005203 ThiS interaction site; other site 195103005204 putative active site [active] 195103005205 tetramer interface [polypeptide binding]; other site 195103005206 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 195103005207 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 195103005208 putative ATP binding site [chemical binding]; other site 195103005209 putative substrate interface [chemical binding]; other site 195103005210 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 195103005211 thiS-thiF/thiG interaction site; other site 195103005212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103005213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195103005214 putative substrate translocation pore; other site 195103005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103005216 putative substrate translocation pore; other site 195103005217 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 195103005218 synthetase active site [active] 195103005219 NTP binding site [chemical binding]; other site 195103005220 metal binding site [ion binding]; metal-binding site 195103005221 methionine sulfoxide reductase B; Provisional; Region: PRK00222 195103005222 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 195103005223 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 195103005224 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 195103005225 NodB motif; other site 195103005226 active site 195103005227 catalytic site [active] 195103005228 Zn binding site [ion binding]; other site 195103005229 Uncharacterized conserved protein [Function unknown]; Region: COG0398 195103005230 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 195103005231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 195103005232 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195103005233 Peptidase family M23; Region: Peptidase_M23; pfam01551 195103005234 hypothetical protein; Provisional; Region: PRK13678 195103005235 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 195103005236 Part of AAA domain; Region: AAA_19; pfam13245 195103005237 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 195103005238 Cation efflux family; Region: Cation_efflux; cl00316 195103005239 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 195103005240 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 195103005241 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 195103005242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103005243 ATP binding site [chemical binding]; other site 195103005244 putative Mg++ binding site [ion binding]; other site 195103005245 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103005246 nucleotide binding region [chemical binding]; other site 195103005247 ATP-binding site [chemical binding]; other site 195103005248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103005249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103005250 DNA binding site [nucleotide binding] 195103005251 domain linker motif; other site 195103005252 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 195103005253 dimerization interface [polypeptide binding]; other site 195103005254 ligand binding site [chemical binding]; other site 195103005255 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 195103005256 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 195103005257 TM-ABC transporter signature motif; other site 195103005258 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 195103005259 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 195103005260 Walker A/P-loop; other site 195103005261 ATP binding site [chemical binding]; other site 195103005262 Q-loop/lid; other site 195103005263 ABC transporter signature motif; other site 195103005264 Walker B; other site 195103005265 D-loop; other site 195103005266 H-loop/switch region; other site 195103005267 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 195103005268 D-ribose pyranase; Provisional; Region: PRK11797 195103005269 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 195103005270 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 195103005271 substrate binding site [chemical binding]; other site 195103005272 dimer interface [polypeptide binding]; other site 195103005273 ATP binding site [chemical binding]; other site 195103005274 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 195103005275 active site 195103005276 catalytic residues [active] 195103005277 metal binding site [ion binding]; metal-binding site 195103005278 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 195103005279 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 195103005280 Mg++ binding site [ion binding]; other site 195103005281 putative catalytic motif [active] 195103005282 substrate binding site [chemical binding]; other site 195103005283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103005284 dimerization interface [polypeptide binding]; other site 195103005285 putative DNA binding site [nucleotide binding]; other site 195103005286 putative Zn2+ binding site [ion binding]; other site 195103005287 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 195103005288 V-type ATP synthase subunit B; Provisional; Region: PRK04196 195103005289 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 195103005290 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 195103005291 Walker A motif homologous position; other site 195103005292 Walker B motif; other site 195103005293 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 195103005294 V-type ATP synthase subunit A; Provisional; Region: PRK04192 195103005295 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 195103005296 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 195103005297 Walker A motif/ATP binding site; other site 195103005298 Walker B motif; other site 195103005299 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 195103005300 V-type ATP synthase subunit F; Provisional; Region: PRK01395 195103005301 V-type ATP synthase subunit C; Provisional; Region: PRK01198 195103005302 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 195103005303 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 195103005304 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 195103005305 V-type ATP synthase subunit K; Validated; Region: PRK06558 195103005306 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 195103005307 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 195103005308 V-type ATP synthase subunit I; Validated; Region: PRK05771 195103005309 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 195103005310 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 195103005311 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 195103005312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103005313 FeS/SAM binding site; other site 195103005314 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 195103005315 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 195103005316 stage V sporulation protein B; Region: spore_V_B; TIGR02900 195103005317 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 195103005318 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 195103005319 S1 domain; Region: S1_2; pfam13509 195103005320 S1 domain; Region: S1_2; pfam13509 195103005321 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 195103005322 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 195103005323 trimer interface [polypeptide binding]; other site 195103005324 putative metal binding site [ion binding]; other site 195103005325 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 195103005326 active site 195103005327 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 195103005328 AsnC family; Region: AsnC_trans_reg; pfam01037 195103005329 Uncharacterized conserved protein [Function unknown]; Region: COG2155 195103005330 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 195103005331 active site 195103005332 metal-binding site [ion binding] 195103005333 nucleotide-binding site [chemical binding]; other site 195103005334 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 195103005335 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 195103005336 RNase_H superfamily; Region: RNase_H_2; pfam13482 195103005337 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 195103005338 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 195103005339 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 195103005340 G1 box; other site 195103005341 GTP/Mg2+ binding site [chemical binding]; other site 195103005342 Switch I region; other site 195103005343 G2 box; other site 195103005344 G3 box; other site 195103005345 Switch II region; other site 195103005346 G4 box; other site 195103005347 G5 box; other site 195103005348 Nucleoside recognition; Region: Gate; pfam07670 195103005349 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 195103005350 Nucleoside recognition; Region: Gate; pfam07670 195103005351 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 195103005352 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 195103005353 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 195103005354 active site 195103005355 HIGH motif; other site 195103005356 KMSK motif region; other site 195103005357 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 195103005358 tRNA binding surface [nucleotide binding]; other site 195103005359 anticodon binding site; other site 195103005360 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 195103005361 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 195103005362 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 195103005363 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 195103005364 putative active site [active] 195103005365 putative metal binding site [ion binding]; other site 195103005366 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 195103005367 Peptidase family M50; Region: Peptidase_M50; pfam02163 195103005368 active site 195103005369 putative substrate binding region [chemical binding]; other site 195103005370 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 195103005371 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 195103005372 putative active site [active] 195103005373 PhoH-like protein; Region: PhoH; pfam02562 195103005374 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 195103005375 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 195103005376 active site 195103005377 catalytic site [active] 195103005378 substrate binding site [chemical binding]; other site 195103005379 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 195103005380 dimer interface [polypeptide binding]; other site 195103005381 ssDNA binding site [nucleotide binding]; other site 195103005382 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195103005383 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 195103005384 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 195103005385 tetramer interface [polypeptide binding]; other site 195103005386 active site 195103005387 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 195103005388 dimerization domain swap beta strand [polypeptide binding]; other site 195103005389 regulatory protein interface [polypeptide binding]; other site 195103005390 active site 195103005391 regulatory phosphorylation site [posttranslational modification]; other site 195103005392 aspartate aminotransferase; Provisional; Region: PRK05764 195103005393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103005394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103005395 homodimer interface [polypeptide binding]; other site 195103005396 catalytic residue [active] 195103005397 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 195103005398 phosphodiesterase; Provisional; Region: PRK12704 195103005399 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 195103005400 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103005401 Zn2+ binding site [ion binding]; other site 195103005402 Mg2+ binding site [ion binding]; other site 195103005403 recombinase A; Provisional; Region: recA; PRK09354 195103005404 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 195103005405 hexamer interface [polypeptide binding]; other site 195103005406 Walker A motif; other site 195103005407 ATP binding site [chemical binding]; other site 195103005408 Walker B motif; other site 195103005409 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 195103005410 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 195103005411 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 195103005412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103005413 FeS/SAM binding site; other site 195103005414 Acyltransferase family; Region: Acyl_transf_3; pfam01757 195103005415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103005416 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 195103005417 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 195103005418 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 195103005419 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 195103005420 active site 195103005421 aspartate kinase I; Reviewed; Region: PRK08210 195103005422 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 195103005423 putative catalytic residues [active] 195103005424 putative nucleotide binding site [chemical binding]; other site 195103005425 putative aspartate binding site [chemical binding]; other site 195103005426 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 195103005427 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 195103005428 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 195103005429 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 195103005430 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 195103005431 RNase E interface [polypeptide binding]; other site 195103005432 trimer interface [polypeptide binding]; other site 195103005433 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 195103005434 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 195103005435 RNase E interface [polypeptide binding]; other site 195103005436 trimer interface [polypeptide binding]; other site 195103005437 active site 195103005438 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 195103005439 putative nucleic acid binding region [nucleotide binding]; other site 195103005440 G-X-X-G motif; other site 195103005441 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 195103005442 RNA binding site [nucleotide binding]; other site 195103005443 domain interface; other site 195103005444 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 195103005445 16S/18S rRNA binding site [nucleotide binding]; other site 195103005446 S13e-L30e interaction site [polypeptide binding]; other site 195103005447 25S rRNA binding site [nucleotide binding]; other site 195103005448 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 195103005449 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 195103005450 active site 195103005451 Riboflavin kinase; Region: Flavokinase; smart00904 195103005452 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 195103005453 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 195103005454 RNA binding site [nucleotide binding]; other site 195103005455 active site 195103005456 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 195103005457 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 195103005458 DHH family; Region: DHH; pfam01368 195103005459 DHHA1 domain; Region: DHHA1; pfam02272 195103005460 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 195103005461 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 195103005462 translation initiation factor IF-2; Region: IF-2; TIGR00487 195103005463 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 195103005464 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 195103005465 G1 box; other site 195103005466 putative GEF interaction site [polypeptide binding]; other site 195103005467 GTP/Mg2+ binding site [chemical binding]; other site 195103005468 Switch I region; other site 195103005469 G2 box; other site 195103005470 G3 box; other site 195103005471 Switch II region; other site 195103005472 G4 box; other site 195103005473 G5 box; other site 195103005474 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 195103005475 Translation-initiation factor 2; Region: IF-2; pfam11987 195103005476 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 195103005477 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 195103005478 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 195103005479 putative RNA binding cleft [nucleotide binding]; other site 195103005480 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 195103005481 NusA N-terminal domain; Region: NusA_N; pfam08529 195103005482 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 195103005483 RNA binding site [nucleotide binding]; other site 195103005484 homodimer interface [polypeptide binding]; other site 195103005485 NusA-like KH domain; Region: KH_5; pfam13184 195103005486 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 195103005487 G-X-X-G motif; other site 195103005488 ribosome maturation protein RimP; Reviewed; Region: PRK00092 195103005489 Sm and related proteins; Region: Sm_like; cl00259 195103005490 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 195103005491 putative oligomer interface [polypeptide binding]; other site 195103005492 putative RNA binding site [nucleotide binding]; other site 195103005493 DNA polymerase III PolC; Validated; Region: polC; PRK00448 195103005494 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 195103005495 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 195103005496 generic binding surface II; other site 195103005497 generic binding surface I; other site 195103005498 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 195103005499 active site 195103005500 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 195103005501 active site 195103005502 catalytic site [active] 195103005503 substrate binding site [chemical binding]; other site 195103005504 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 195103005505 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 195103005506 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 195103005507 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 195103005508 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 195103005509 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 195103005510 active site 195103005511 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 195103005512 protein binding site [polypeptide binding]; other site 195103005513 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 195103005514 putative substrate binding region [chemical binding]; other site 195103005515 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 195103005516 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 195103005517 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 195103005518 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 195103005519 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 195103005520 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 195103005521 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 195103005522 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 195103005523 catalytic residue [active] 195103005524 putative FPP diphosphate binding site; other site 195103005525 putative FPP binding hydrophobic cleft; other site 195103005526 dimer interface [polypeptide binding]; other site 195103005527 putative IPP diphosphate binding site; other site 195103005528 ribosome recycling factor; Reviewed; Region: frr; PRK00083 195103005529 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 195103005530 hinge region; other site 195103005531 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 195103005532 putative nucleotide binding site [chemical binding]; other site 195103005533 uridine monophosphate binding site [chemical binding]; other site 195103005534 homohexameric interface [polypeptide binding]; other site 195103005535 elongation factor Ts; Provisional; Region: tsf; PRK09377 195103005536 UBA/TS-N domain; Region: UBA; pfam00627 195103005537 Elongation factor TS; Region: EF_TS; pfam00889 195103005538 Elongation factor TS; Region: EF_TS; pfam00889 195103005539 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 195103005540 rRNA interaction site [nucleotide binding]; other site 195103005541 S8 interaction site; other site 195103005542 putative laminin-1 binding site; other site 195103005543 transcriptional repressor CodY; Validated; Region: PRK04158 195103005544 CodY GAF-like domain; Region: CodY; pfam06018 195103005545 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 195103005546 DNA topoisomerase I; Validated; Region: PRK05582 195103005547 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 195103005548 active site 195103005549 interdomain interaction site; other site 195103005550 putative metal-binding site [ion binding]; other site 195103005551 nucleotide binding site [chemical binding]; other site 195103005552 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 195103005553 domain I; other site 195103005554 DNA binding groove [nucleotide binding] 195103005555 phosphate binding site [ion binding]; other site 195103005556 domain II; other site 195103005557 domain III; other site 195103005558 nucleotide binding site [chemical binding]; other site 195103005559 catalytic site [active] 195103005560 domain IV; other site 195103005561 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 195103005562 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 195103005563 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 195103005564 DNA protecting protein DprA; Region: dprA; TIGR00732 195103005565 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 195103005566 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 195103005567 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 195103005568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103005569 Walker A motif; other site 195103005570 ATP binding site [chemical binding]; other site 195103005571 Walker B motif; other site 195103005572 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 195103005573 hypothetical protein; Reviewed; Region: PRK12497 195103005574 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 195103005575 RNA/DNA hybrid binding site [nucleotide binding]; other site 195103005576 active site 195103005577 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 195103005578 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 195103005579 GTP/Mg2+ binding site [chemical binding]; other site 195103005580 G4 box; other site 195103005581 G5 box; other site 195103005582 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 195103005583 G1 box; other site 195103005584 Switch I region; other site 195103005585 G2 box; other site 195103005586 G3 box; other site 195103005587 Switch II region; other site 195103005588 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 195103005589 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 195103005590 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 195103005591 RimM N-terminal domain; Region: RimM; pfam01782 195103005592 PRC-barrel domain; Region: PRC; pfam05239 195103005593 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 195103005594 hypothetical protein; Provisional; Region: PRK00468 195103005595 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 195103005596 signal recognition particle protein; Provisional; Region: PRK10867 195103005597 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 195103005598 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 195103005599 P loop; other site 195103005600 GTP binding site [chemical binding]; other site 195103005601 Signal peptide binding domain; Region: SRP_SPB; pfam02978 195103005602 putative DNA-binding protein; Validated; Region: PRK00118 195103005603 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 195103005604 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 195103005605 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 195103005606 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 195103005607 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 195103005608 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 195103005609 Walker A/P-loop; other site 195103005610 ATP binding site [chemical binding]; other site 195103005611 Q-loop/lid; other site 195103005612 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 195103005613 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 195103005614 ABC transporter signature motif; other site 195103005615 Walker B; other site 195103005616 D-loop; other site 195103005617 H-loop/switch region; other site 195103005618 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 195103005619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103005620 FeS/SAM binding site; other site 195103005621 ribonuclease III; Reviewed; Region: rnc; PRK00102 195103005622 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 195103005623 dimerization interface [polypeptide binding]; other site 195103005624 active site 195103005625 metal binding site [ion binding]; metal-binding site 195103005626 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 195103005627 dsRNA binding site [nucleotide binding]; other site 195103005628 acyl carrier protein; Provisional; Region: acpP; PRK00982 195103005629 putative phosphate acyltransferase; Provisional; Region: PRK05331 195103005630 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 195103005631 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 195103005632 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 195103005633 propionate/acetate kinase; Provisional; Region: PRK12379 195103005634 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 195103005635 hypothetical protein; Provisional; Region: PRK13670 195103005636 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 195103005637 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 195103005638 Nucleoside recognition; Region: Gate; pfam07670 195103005639 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 195103005640 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 195103005641 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 195103005642 active site 195103005643 (T/H)XGH motif; other site 195103005644 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 195103005645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103005646 S-adenosylmethionine binding site [chemical binding]; other site 195103005647 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 195103005648 Uncharacterized conserved protein [Function unknown]; Region: COG3743 195103005649 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 195103005650 ssDNA binding site; other site 195103005651 generic binding surface II; other site 195103005652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103005653 ATP binding site [chemical binding]; other site 195103005654 putative Mg++ binding site [ion binding]; other site 195103005655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103005656 nucleotide binding region [chemical binding]; other site 195103005657 ATP-binding site [chemical binding]; other site 195103005658 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 195103005659 DAK2 domain; Region: Dak2; pfam02734 195103005660 Asp23 family; Region: Asp23; pfam03780 195103005661 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 195103005662 Thiamine pyrophosphokinase; Region: TPK; cd07995 195103005663 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 195103005664 active site 195103005665 dimerization interface [polypeptide binding]; other site 195103005666 thiamine binding site [chemical binding]; other site 195103005667 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 195103005668 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 195103005669 substrate binding site [chemical binding]; other site 195103005670 hexamer interface [polypeptide binding]; other site 195103005671 metal binding site [ion binding]; metal-binding site 195103005672 GTPase RsgA; Reviewed; Region: PRK00098 195103005673 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 195103005674 RNA binding site [nucleotide binding]; other site 195103005675 homodimer interface [polypeptide binding]; other site 195103005676 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 195103005677 GTPase/Zn-binding domain interface [polypeptide binding]; other site 195103005678 GTP/Mg2+ binding site [chemical binding]; other site 195103005679 G4 box; other site 195103005680 G5 box; other site 195103005681 G1 box; other site 195103005682 Switch I region; other site 195103005683 G2 box; other site 195103005684 G3 box; other site 195103005685 Switch II region; other site 195103005686 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 195103005687 Catalytic domain of Protein Kinases; Region: PKc; cd00180 195103005688 active site 195103005689 ATP binding site [chemical binding]; other site 195103005690 substrate binding site [chemical binding]; other site 195103005691 activation loop (A-loop); other site 195103005692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 195103005693 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 195103005694 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 195103005695 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 195103005696 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 195103005697 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 195103005698 Protein phosphatase 2C; Region: PP2C; pfam00481 195103005699 active site 195103005700 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 195103005701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103005702 FeS/SAM binding site; other site 195103005703 16S rRNA methyltransferase B; Provisional; Region: PRK14902 195103005704 NusB family; Region: NusB; pfam01029 195103005705 putative RNA binding site [nucleotide binding]; other site 195103005706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103005707 S-adenosylmethionine binding site [chemical binding]; other site 195103005708 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 195103005709 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 195103005710 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 195103005711 putative active site [active] 195103005712 substrate binding site [chemical binding]; other site 195103005713 putative cosubstrate binding site; other site 195103005714 catalytic site [active] 195103005715 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 195103005716 substrate binding site [chemical binding]; other site 195103005717 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 195103005718 active site 195103005719 catalytic residues [active] 195103005720 metal binding site [ion binding]; metal-binding site 195103005721 primosome assembly protein PriA; Validated; Region: PRK05580 195103005722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103005723 ATP binding site [chemical binding]; other site 195103005724 putative Mg++ binding site [ion binding]; other site 195103005725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103005726 ATP-binding site [chemical binding]; other site 195103005727 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 195103005728 Flavoprotein; Region: Flavoprotein; pfam02441 195103005729 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 195103005730 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 195103005731 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 195103005732 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 195103005733 catalytic site [active] 195103005734 G-X2-G-X-G-K; other site 195103005735 hypothetical protein; Provisional; Region: PRK04323 195103005736 hypothetical protein; Provisional; Region: PRK11820 195103005737 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 195103005738 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 195103005739 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 195103005740 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 195103005741 active site 195103005742 homotetramer interface [polypeptide binding]; other site 195103005743 homodimer interface [polypeptide binding]; other site 195103005744 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 195103005745 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 195103005746 G1 box; other site 195103005747 GTP/Mg2+ binding site [chemical binding]; other site 195103005748 G2 box; other site 195103005749 Switch I region; other site 195103005750 G3 box; other site 195103005751 Switch II region; other site 195103005752 G5 box; other site 195103005753 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 195103005754 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 195103005755 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 195103005756 GTP-binding protein Der; Reviewed; Region: PRK00093 195103005757 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 195103005758 G1 box; other site 195103005759 GTP/Mg2+ binding site [chemical binding]; other site 195103005760 Switch I region; other site 195103005761 G2 box; other site 195103005762 Switch II region; other site 195103005763 G3 box; other site 195103005764 G4 box; other site 195103005765 G5 box; other site 195103005766 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 195103005767 G1 box; other site 195103005768 GTP/Mg2+ binding site [chemical binding]; other site 195103005769 Switch I region; other site 195103005770 G2 box; other site 195103005771 G3 box; other site 195103005772 Switch II region; other site 195103005773 G4 box; other site 195103005774 G5 box; other site 195103005775 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 195103005776 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 195103005777 Protein of unknown function (DUF512); Region: DUF512; pfam04459 195103005778 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 195103005779 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 195103005780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103005781 dimerization interface [polypeptide binding]; other site 195103005782 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 195103005783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195103005784 putative active site [active] 195103005785 heme pocket [chemical binding]; other site 195103005786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103005787 dimer interface [polypeptide binding]; other site 195103005788 phosphorylation site [posttranslational modification] 195103005789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103005790 ATP binding site [chemical binding]; other site 195103005791 Mg2+ binding site [ion binding]; other site 195103005792 G-X-G motif; other site 195103005793 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 195103005794 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 195103005795 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 195103005796 ATP cone domain; Region: ATP-cone; pfam03477 195103005797 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 195103005798 sporulation sigma factor SigG; Reviewed; Region: PRK08215 195103005799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103005800 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 195103005801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195103005802 DNA binding residues [nucleotide binding] 195103005803 sporulation sigma factor SigE; Reviewed; Region: PRK08301 195103005804 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103005805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195103005806 DNA binding residues [nucleotide binding] 195103005807 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 195103005808 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 195103005809 cell division protein FtsZ; Validated; Region: PRK09330 195103005810 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 195103005811 nucleotide binding site [chemical binding]; other site 195103005812 SulA interaction site; other site 195103005813 cell division protein FtsA; Region: ftsA; TIGR01174 195103005814 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103005815 nucleotide binding site [chemical binding]; other site 195103005816 Cell division protein FtsA; Region: FtsA; pfam14450 195103005817 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 195103005818 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 195103005819 Walker A motif; other site 195103005820 ATP binding site [chemical binding]; other site 195103005821 Walker B motif; other site 195103005822 RNA polymerase sigma-K factor; Region: spore_sigmaK; TIGR02846 195103005823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103005824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195103005825 DNA binding residues [nucleotide binding] 195103005826 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 195103005827 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 195103005828 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 195103005829 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 195103005830 Sugar specificity; other site 195103005831 Pyrimidine base specificity; other site 195103005832 ATP-binding site [chemical binding]; other site 195103005833 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 195103005834 Peptidase family U32; Region: Peptidase_U32; pfam01136 195103005835 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 195103005836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103005837 S-adenosylmethionine binding site [chemical binding]; other site 195103005838 YceG-like family; Region: YceG; pfam02618 195103005839 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 195103005840 dimerization interface [polypeptide binding]; other site 195103005841 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 195103005842 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 195103005843 G1 box; other site 195103005844 putative GEF interaction site [polypeptide binding]; other site 195103005845 GTP/Mg2+ binding site [chemical binding]; other site 195103005846 Switch I region; other site 195103005847 G2 box; other site 195103005848 G3 box; other site 195103005849 Switch II region; other site 195103005850 G4 box; other site 195103005851 G5 box; other site 195103005852 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 195103005853 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 195103005854 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 195103005855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 195103005856 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 195103005857 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 195103005858 metal binding site 2 [ion binding]; metal-binding site 195103005859 putative DNA binding helix; other site 195103005860 metal binding site 1 [ion binding]; metal-binding site 195103005861 dimer interface [polypeptide binding]; other site 195103005862 structural Zn2+ binding site [ion binding]; other site 195103005863 hypothetical protein; Provisional; Region: PRK13678 195103005864 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 195103005865 hypothetical protein; Provisional; Region: PRK05473 195103005866 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 195103005867 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 195103005868 motif 1; other site 195103005869 active site 195103005870 motif 2; other site 195103005871 motif 3; other site 195103005872 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 195103005873 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 195103005874 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 195103005875 PRC-barrel domain; Region: PRC; pfam05239 195103005876 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 195103005877 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 195103005878 Ligand Binding Site [chemical binding]; other site 195103005879 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 195103005880 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 195103005881 trimerization site [polypeptide binding]; other site 195103005882 active site 195103005883 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 195103005884 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 195103005885 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103005886 catalytic residue [active] 195103005887 Transcriptional regulator; Region: Rrf2; cl17282 195103005888 Rrf2 family protein; Region: rrf2_super; TIGR00738 195103005889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 195103005890 metal binding site [ion binding]; metal-binding site 195103005891 active site 195103005892 I-site; other site 195103005893 MOSC domain; Region: MOSC; pfam03473 195103005894 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 195103005895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103005896 FeS/SAM binding site; other site 195103005897 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 195103005898 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 195103005899 putative MPT binding site; other site 195103005900 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 195103005901 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 195103005902 GTP binding site; other site 195103005903 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 195103005904 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 195103005905 dimer interface [polypeptide binding]; other site 195103005906 putative functional site; other site 195103005907 putative MPT binding site; other site 195103005908 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 195103005909 Walker A motif; other site 195103005910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 195103005911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195103005912 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 195103005913 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 195103005914 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 195103005915 [4Fe-4S] binding site [ion binding]; other site 195103005916 molybdopterin cofactor binding site; other site 195103005917 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 195103005918 molybdopterin cofactor binding site; other site 195103005919 Predicted membrane protein [Function unknown]; Region: COG4640 195103005920 Glucose inhibited division protein A; Region: GIDA; pfam01134 195103005921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195103005922 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 195103005923 hypothetical protein; Provisional; Region: PRK05802 195103005924 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 195103005925 FAD binding pocket [chemical binding]; other site 195103005926 FAD binding motif [chemical binding]; other site 195103005927 phosphate binding motif [ion binding]; other site 195103005928 beta-alpha-beta structure motif; other site 195103005929 NAD binding pocket [chemical binding]; other site 195103005930 Iron coordination center [ion binding]; other site 195103005931 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 195103005932 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 195103005933 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 195103005934 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 195103005935 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 195103005936 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 195103005937 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 195103005938 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 195103005939 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 195103005940 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 195103005941 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 195103005942 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 195103005943 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 195103005944 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 195103005945 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 195103005946 active site 195103005947 DNA binding site [nucleotide binding] 195103005948 Int/Topo IB signature motif; other site 195103005949 stage II sporulation protein M; Region: spo_II_M; TIGR02831 195103005950 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 195103005951 dimer interface [polypeptide binding]; other site 195103005952 ADP-ribose binding site [chemical binding]; other site 195103005953 active site 195103005954 nudix motif; other site 195103005955 metal binding site [ion binding]; metal-binding site 195103005956 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 195103005957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103005958 active site 195103005959 phosphorylation site [posttranslational modification] 195103005960 intermolecular recognition site; other site 195103005961 dimerization interface [polypeptide binding]; other site 195103005962 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 195103005963 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 195103005964 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 195103005965 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 195103005966 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 195103005967 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 195103005968 Walker A/P-loop; other site 195103005969 ATP binding site [chemical binding]; other site 195103005970 Q-loop/lid; other site 195103005971 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 195103005972 ABC transporter signature motif; other site 195103005973 Walker B; other site 195103005974 D-loop; other site 195103005975 H-loop/switch region; other site 195103005976 arginine repressor; Provisional; Region: argR; PRK00441 195103005977 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 195103005978 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 195103005979 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 195103005980 ATP-NAD kinase; Region: NAD_kinase; pfam01513 195103005981 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 195103005982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103005983 RNA binding surface [nucleotide binding]; other site 195103005984 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 195103005985 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 195103005986 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 195103005987 TPP-binding site; other site 195103005988 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 195103005989 PYR/PP interface [polypeptide binding]; other site 195103005990 dimer interface [polypeptide binding]; other site 195103005991 TPP binding site [chemical binding]; other site 195103005992 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 195103005993 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 195103005994 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 195103005995 substrate binding pocket [chemical binding]; other site 195103005996 chain length determination region; other site 195103005997 substrate-Mg2+ binding site; other site 195103005998 catalytic residues [active] 195103005999 aspartate-rich region 1; other site 195103006000 active site lid residues [active] 195103006001 aspartate-rich region 2; other site 195103006002 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 195103006003 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 195103006004 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 195103006005 generic binding surface I; other site 195103006006 generic binding surface II; other site 195103006007 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 195103006008 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 195103006009 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 195103006010 homodimer interface [polypeptide binding]; other site 195103006011 NADP binding site [chemical binding]; other site 195103006012 substrate binding site [chemical binding]; other site 195103006013 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 195103006014 putative RNA binding site [nucleotide binding]; other site 195103006015 Asp23 family; Region: Asp23; pfam03780 195103006016 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 195103006017 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 195103006018 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 195103006019 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 195103006020 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 195103006021 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 195103006022 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 195103006023 stage III sporulation protein AB; Region: spore_III_AB; TIGR02833 195103006024 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 195103006025 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 195103006026 Walker A motif; other site 195103006027 ATP binding site [chemical binding]; other site 195103006028 elongation factor P; Validated; Region: PRK00529 195103006029 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 195103006030 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 195103006031 RNA binding site [nucleotide binding]; other site 195103006032 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 195103006033 RNA binding site [nucleotide binding]; other site 195103006034 hypothetical protein; Provisional; Region: PRK10557 195103006035 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 195103006036 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 195103006037 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 195103006038 Type II/IV secretion system protein; Region: T2SE; pfam00437 195103006039 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 195103006040 Walker A motif; other site 195103006041 ATP binding site [chemical binding]; other site 195103006042 Walker B motif; other site 195103006043 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 195103006044 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 195103006045 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 195103006046 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 195103006047 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 195103006048 Domain of unknown function (DUF814); Region: DUF814; pfam05670 195103006049 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 195103006050 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 195103006051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 195103006052 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 195103006053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103006054 active site 195103006055 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 195103006056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103006057 RNA binding surface [nucleotide binding]; other site 195103006058 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 195103006059 active site 195103006060 DivIVA protein; Region: DivIVA; pfam05103 195103006061 DivIVA domain; Region: DivI1A_domain; TIGR03544 195103006062 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 195103006063 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103006064 RNA binding surface [nucleotide binding]; other site 195103006065 Protein of unknown function (DUF552); Region: DUF552; cl00775 195103006066 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 195103006067 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 195103006068 catalytic residue [active] 195103006069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 195103006070 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 195103006071 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 195103006072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 195103006073 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 195103006074 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 195103006075 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 195103006076 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 195103006077 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 195103006078 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 195103006079 Mg++ binding site [ion binding]; other site 195103006080 putative catalytic motif [active] 195103006081 putative substrate binding site [chemical binding]; other site 195103006082 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 195103006083 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 195103006084 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103006085 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195103006086 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 195103006087 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 195103006088 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103006089 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195103006090 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 195103006091 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 195103006092 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 195103006093 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 195103006094 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 195103006095 Cell division protein FtsL; Region: FtsL; cl11433 195103006096 MraW methylase family; Region: Methyltransf_5; pfam01795 195103006097 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 195103006098 GTP-binding protein YchF; Reviewed; Region: PRK09601 195103006099 YchF GTPase; Region: YchF; cd01900 195103006100 G1 box; other site 195103006101 GTP/Mg2+ binding site [chemical binding]; other site 195103006102 Switch I region; other site 195103006103 G2 box; other site 195103006104 Switch II region; other site 195103006105 G3 box; other site 195103006106 G4 box; other site 195103006107 G5 box; other site 195103006108 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 195103006109 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 195103006110 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 195103006111 NodB motif; other site 195103006112 active site 195103006113 catalytic site [active] 195103006114 Cd binding site [ion binding]; other site 195103006115 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 195103006116 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103006117 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195103006118 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 195103006119 Tetratricopeptide repeat; Region: TPR_12; pfam13424 195103006120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103006121 binding surface 195103006122 TPR motif; other site 195103006123 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 195103006124 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 195103006125 active site 195103006126 substrate binding site [chemical binding]; other site 195103006127 metal binding site [ion binding]; metal-binding site 195103006128 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 195103006129 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 195103006130 5S rRNA interface [nucleotide binding]; other site 195103006131 CTC domain interface [polypeptide binding]; other site 195103006132 L16 interface [polypeptide binding]; other site 195103006133 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 195103006134 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 195103006135 Interdomain contacts; other site 195103006136 Cytokine receptor motif; other site 195103006137 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 195103006138 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 195103006139 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 195103006140 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 195103006141 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 195103006142 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 195103006143 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 195103006144 sugar binding site [chemical binding]; other site 195103006145 Calx-beta domain; Region: Calx-beta; pfam03160 195103006146 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 195103006147 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 195103006148 active site 195103006149 catalytic site [active] 195103006150 metal binding site [ion binding]; metal-binding site 195103006151 dimer interface [polypeptide binding]; other site 195103006152 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 195103006153 active site 195103006154 substrate binding site [chemical binding]; other site 195103006155 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 195103006156 FMN binding site [chemical binding]; other site 195103006157 putative catalytic residues [active] 195103006158 Uncharacterized conserved protein [Function unknown]; Region: COG1683 195103006159 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 195103006160 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 195103006161 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 195103006162 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 195103006163 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 195103006164 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 195103006165 MutS domain III; Region: MutS_III; pfam05192 195103006166 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 195103006167 Walker A/P-loop; other site 195103006168 ATP binding site [chemical binding]; other site 195103006169 Q-loop/lid; other site 195103006170 ABC transporter signature motif; other site 195103006171 Walker B; other site 195103006172 D-loop; other site 195103006173 H-loop/switch region; other site 195103006174 Smr domain; Region: Smr; pfam01713 195103006175 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 195103006176 Peptidase family U32; Region: Peptidase_U32; pfam01136 195103006177 Collagenase; Region: DUF3656; pfam12392 195103006178 Peptidase family U32; Region: Peptidase_U32; cl03113 195103006179 histidinol-phosphatase; Provisional; Region: PRK05588 195103006180 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 195103006181 active site 195103006182 Cell division protein ZapA; Region: ZapA; pfam05164 195103006183 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 195103006184 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 195103006185 putative tRNA-binding site [nucleotide binding]; other site 195103006186 B3/4 domain; Region: B3_4; pfam03483 195103006187 tRNA synthetase B5 domain; Region: B5; smart00874 195103006188 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 195103006189 dimer interface [polypeptide binding]; other site 195103006190 motif 1; other site 195103006191 motif 3; other site 195103006192 motif 2; other site 195103006193 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 195103006194 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 195103006195 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 195103006196 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 195103006197 dimer interface [polypeptide binding]; other site 195103006198 motif 1; other site 195103006199 active site 195103006200 motif 2; other site 195103006201 motif 3; other site 195103006202 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 195103006203 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 195103006204 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 195103006205 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 195103006206 TrkA-N domain; Region: TrkA_N; pfam02254 195103006207 TrkA-C domain; Region: TrkA_C; pfam02080 195103006208 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 195103006209 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 195103006210 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 195103006211 23S rRNA binding site [nucleotide binding]; other site 195103006212 L21 binding site [polypeptide binding]; other site 195103006213 L13 binding site [polypeptide binding]; other site 195103006214 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 195103006215 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 195103006216 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 195103006217 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 195103006218 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 195103006219 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 195103006220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103006221 nucleotide binding site [chemical binding]; other site 195103006222 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 195103006223 dimer interface [polypeptide binding]; other site 195103006224 ADP-ribose binding site [chemical binding]; other site 195103006225 active site 195103006226 nudix motif; other site 195103006227 metal binding site [ion binding]; metal-binding site 195103006228 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 195103006229 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 195103006230 dimerization interface [polypeptide binding]; other site 195103006231 domain crossover interface; other site 195103006232 redox-dependent activation switch; other site 195103006233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103006234 S-adenosylmethionine binding site [chemical binding]; other site 195103006235 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 195103006236 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 195103006237 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 195103006238 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 195103006239 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 195103006240 dimer interface [polypeptide binding]; other site 195103006241 active site 195103006242 catalytic residue [active] 195103006243 dihydrodipicolinate reductase; Provisional; Region: PRK00048 195103006244 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 195103006245 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 195103006246 aminotransferase A; Validated; Region: PRK07683 195103006247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103006248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103006249 homodimer interface [polypeptide binding]; other site 195103006250 catalytic residue [active] 195103006251 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 195103006252 homodimer interface [polypeptide binding]; other site 195103006253 Walker A motif; other site 195103006254 ATP binding site [chemical binding]; other site 195103006255 hydroxycobalamin binding site [chemical binding]; other site 195103006256 Walker B motif; other site 195103006257 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 195103006258 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 195103006259 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 195103006260 active site 195103006261 trimer interface [polypeptide binding]; other site 195103006262 substrate binding site [chemical binding]; other site 195103006263 CoA binding site [chemical binding]; other site 195103006264 single-stranded DNA-binding protein; Provisional; Region: PRK05813 195103006265 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 195103006266 dimer interface [polypeptide binding]; other site 195103006267 ssDNA binding site [nucleotide binding]; other site 195103006268 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195103006269 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 195103006270 NodB motif; other site 195103006271 active site 195103006272 catalytic site [active] 195103006273 metal binding site [ion binding]; metal-binding site 195103006274 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 195103006275 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 195103006276 Domain of unknown function DUF20; Region: UPF0118; pfam01594 195103006277 Transcriptional regulator [Transcription]; Region: LytR; COG1316 195103006278 Haemolysin-III related; Region: HlyIII; cl03831 195103006279 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 195103006280 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 195103006281 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 195103006282 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 195103006283 Cl- selectivity filter; other site 195103006284 Cl- binding residues [ion binding]; other site 195103006285 pore gating glutamate residue; other site 195103006286 dimer interface [polypeptide binding]; other site 195103006287 H+/Cl- coupling transport residue; other site 195103006288 TrkA-C domain; Region: TrkA_C; pfam02080 195103006289 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 195103006290 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103006291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195103006292 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 195103006293 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 195103006294 HIGH motif; other site 195103006295 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 195103006296 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 195103006297 active site 195103006298 KMSKS motif; other site 195103006299 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 195103006300 tRNA binding surface [nucleotide binding]; other site 195103006301 anticodon binding site; other site 195103006302 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 195103006303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103006304 binding surface 195103006305 TPR repeat; Region: TPR_11; pfam13414 195103006306 TPR motif; other site 195103006307 Tetratricopeptide repeat; Region: TPR_12; pfam13424 195103006308 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 195103006309 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 195103006310 RecX family; Region: RecX; cl00936 195103006311 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 195103006312 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 195103006313 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 195103006314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103006315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103006316 active site 195103006317 phosphorylation site [posttranslational modification] 195103006318 intermolecular recognition site; other site 195103006319 dimerization interface [polypeptide binding]; other site 195103006320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103006321 DNA binding site [nucleotide binding] 195103006322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103006323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103006324 dimerization interface [polypeptide binding]; other site 195103006325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103006326 dimer interface [polypeptide binding]; other site 195103006327 phosphorylation site [posttranslational modification] 195103006328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103006329 ATP binding site [chemical binding]; other site 195103006330 Mg2+ binding site [ion binding]; other site 195103006331 G-X-G motif; other site 195103006332 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 195103006333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 195103006334 NAD(P) binding site [chemical binding]; other site 195103006335 active site 195103006336 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 195103006337 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 195103006338 active site 195103006339 dimer interface [polypeptide binding]; other site 195103006340 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 195103006341 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 195103006342 dimer interface [polypeptide binding]; other site 195103006343 active site 195103006344 glycine-pyridoxal phosphate binding site [chemical binding]; other site 195103006345 folate binding site [chemical binding]; other site 195103006346 Uncharacterized conserved protein [Function unknown]; Region: COG2966 195103006347 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 195103006348 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 195103006349 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 195103006350 putative homodimer interface [polypeptide binding]; other site 195103006351 putative homotetramer interface [polypeptide binding]; other site 195103006352 putative allosteric switch controlling residues; other site 195103006353 putative metal binding site [ion binding]; other site 195103006354 putative homodimer-homodimer interface [polypeptide binding]; other site 195103006355 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 195103006356 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 195103006357 dimer interface [polypeptide binding]; other site 195103006358 anticodon binding site; other site 195103006359 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 195103006360 homodimer interface [polypeptide binding]; other site 195103006361 motif 1; other site 195103006362 active site 195103006363 motif 2; other site 195103006364 GAD domain; Region: GAD; pfam02938 195103006365 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 195103006366 motif 3; other site 195103006367 histidyl-tRNA synthetase; Region: hisS; TIGR00442 195103006368 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 195103006369 dimer interface [polypeptide binding]; other site 195103006370 motif 1; other site 195103006371 active site 195103006372 motif 2; other site 195103006373 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 195103006374 anticodon binding site; other site 195103006375 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 195103006376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103006377 FeS/SAM binding site; other site 195103006378 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 195103006379 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 195103006380 putative active site [active] 195103006381 dimerization interface [polypeptide binding]; other site 195103006382 putative tRNAtyr binding site [nucleotide binding]; other site 195103006383 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 195103006384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103006385 Zn2+ binding site [ion binding]; other site 195103006386 Mg2+ binding site [ion binding]; other site 195103006387 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 195103006388 synthetase active site [active] 195103006389 NTP binding site [chemical binding]; other site 195103006390 metal binding site [ion binding]; metal-binding site 195103006391 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 195103006392 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 195103006393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103006394 active site 195103006395 DHH family; Region: DHH; pfam01368 195103006396 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 195103006397 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 195103006398 Protein export membrane protein; Region: SecD_SecF; pfam02355 195103006399 protein-export membrane protein SecD; Region: secD; TIGR01129 195103006400 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 195103006401 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 195103006402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103006403 FeS/SAM binding site; other site 195103006404 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 195103006405 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 195103006406 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 195103006407 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 195103006408 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 195103006409 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 195103006410 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 195103006411 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 195103006412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103006413 Walker A motif; other site 195103006414 ATP binding site [chemical binding]; other site 195103006415 Walker B motif; other site 195103006416 arginine finger; other site 195103006417 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 195103006418 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 195103006419 RuvA N terminal domain; Region: RuvA_N; pfam01330 195103006420 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 195103006421 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 195103006422 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 195103006423 active site 195103006424 metal binding site [ion binding]; metal-binding site 195103006425 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 195103006426 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 195103006427 active site 195103006428 metal binding site [ion binding]; metal-binding site 195103006429 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 195103006430 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 195103006431 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 195103006432 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 195103006433 active site 195103006434 metal binding site [ion binding]; metal-binding site 195103006435 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 195103006436 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 195103006437 active site 195103006438 metal binding site [ion binding]; metal-binding site 195103006439 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 195103006440 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 195103006441 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 195103006442 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 195103006443 heme-binding site [chemical binding]; other site 195103006444 hypothetical protein; Validated; Region: PRK00110 195103006445 Uncharacterized conserved protein [Function unknown]; Region: COG1739 195103006446 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 195103006447 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 195103006448 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 195103006449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103006450 DNA-binding site [nucleotide binding]; DNA binding site 195103006451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 195103006452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103006453 homodimer interface [polypeptide binding]; other site 195103006454 catalytic residue [active] 195103006455 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 195103006456 active site 195103006457 NTP binding site [chemical binding]; other site 195103006458 metal binding triad [ion binding]; metal-binding site 195103006459 antibiotic binding site [chemical binding]; other site 195103006460 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 195103006461 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 195103006462 HflX GTPase family; Region: HflX; cd01878 195103006463 G1 box; other site 195103006464 GTP/Mg2+ binding site [chemical binding]; other site 195103006465 Switch I region; other site 195103006466 G2 box; other site 195103006467 G3 box; other site 195103006468 Switch II region; other site 195103006469 G4 box; other site 195103006470 G5 box; other site 195103006471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103006472 active site 195103006473 sporulation protein YunB; Region: spo_yunB; TIGR02832 195103006474 Transglycosylase; Region: Transgly; pfam00912 195103006475 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 195103006476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 195103006477 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 195103006478 amino acid carrier protein; Region: agcS; TIGR00835 195103006479 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 195103006480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103006481 Coenzyme A binding pocket [chemical binding]; other site 195103006482 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 195103006483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103006484 non-specific DNA binding site [nucleotide binding]; other site 195103006485 salt bridge; other site 195103006486 sequence-specific DNA binding site [nucleotide binding]; other site 195103006487 Cupin domain; Region: Cupin_2; pfam07883 195103006488 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 195103006489 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 195103006490 Walker A/P-loop; other site 195103006491 ATP binding site [chemical binding]; other site 195103006492 Q-loop/lid; other site 195103006493 ABC transporter signature motif; other site 195103006494 Walker B; other site 195103006495 D-loop; other site 195103006496 H-loop/switch region; other site 195103006497 TOBE domain; Region: TOBE_2; pfam08402 195103006498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103006499 dimer interface [polypeptide binding]; other site 195103006500 conserved gate region; other site 195103006501 putative PBP binding loops; other site 195103006502 ABC-ATPase subunit interface; other site 195103006503 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 195103006504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103006505 dimer interface [polypeptide binding]; other site 195103006506 conserved gate region; other site 195103006507 putative PBP binding loops; other site 195103006508 ABC-ATPase subunit interface; other site 195103006509 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 195103006510 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 195103006511 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 195103006512 active site 195103006513 multimer interface [polypeptide binding]; other site 195103006514 Acylphosphatase; Region: Acylphosphatase; pfam00708 195103006515 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 195103006516 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 195103006517 pyrophosphatase PpaX; Provisional; Region: PRK13288 195103006518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 195103006519 motif II; other site 195103006520 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 195103006521 dimer interface [polypeptide binding]; other site 195103006522 active site 195103006523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103006524 TPR motif; other site 195103006525 binding surface 195103006526 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 195103006527 LrgB-like family; Region: LrgB; pfam04172 195103006528 DNA topoisomerase III; Provisional; Region: PRK07726 195103006529 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 195103006530 active site 195103006531 putative interdomain interaction site [polypeptide binding]; other site 195103006532 putative metal-binding site [ion binding]; other site 195103006533 putative nucleotide binding site [chemical binding]; other site 195103006534 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 195103006535 domain I; other site 195103006536 DNA binding groove [nucleotide binding] 195103006537 phosphate binding site [ion binding]; other site 195103006538 domain II; other site 195103006539 domain III; other site 195103006540 nucleotide binding site [chemical binding]; other site 195103006541 catalytic site [active] 195103006542 domain IV; other site 195103006543 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 195103006544 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 195103006545 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 195103006546 active site 195103006547 TspO/MBR family; Region: TspO_MBR; pfam03073 195103006548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103006549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103006550 dimer interface [polypeptide binding]; other site 195103006551 phosphorylation site [posttranslational modification] 195103006552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103006553 ATP binding site [chemical binding]; other site 195103006554 Mg2+ binding site [ion binding]; other site 195103006555 G-X-G motif; other site 195103006556 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 195103006557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103006558 dimer interface [polypeptide binding]; other site 195103006559 phosphorylation site [posttranslational modification] 195103006560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103006561 ATP binding site [chemical binding]; other site 195103006562 Mg2+ binding site [ion binding]; other site 195103006563 G-X-G motif; other site 195103006564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103006565 binding surface 195103006566 TPR motif; other site 195103006567 TPR repeat; Region: TPR_11; pfam13414 195103006568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 195103006569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 195103006570 binding surface 195103006571 TPR motif; other site 195103006572 TPR repeat; Region: TPR_11; pfam13414 195103006573 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 195103006574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 195103006575 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 195103006576 active site 195103006577 ATP binding site [chemical binding]; other site 195103006578 substrate binding site [chemical binding]; other site 195103006579 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 195103006580 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 195103006581 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 195103006582 N-acetyl-D-glucosamine binding site [chemical binding]; other site 195103006583 catalytic residue [active] 195103006584 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 195103006585 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 195103006586 CoA-binding site [chemical binding]; other site 195103006587 ATP-binding [chemical binding]; other site 195103006588 DNA polymerase I; Provisional; Region: PRK05755 195103006589 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 195103006590 active site 195103006591 metal binding site 1 [ion binding]; metal-binding site 195103006592 putative 5' ssDNA interaction site; other site 195103006593 metal binding site 3; metal-binding site 195103006594 metal binding site 2 [ion binding]; metal-binding site 195103006595 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 195103006596 putative DNA binding site [nucleotide binding]; other site 195103006597 putative metal binding site [ion binding]; other site 195103006598 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 195103006599 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 195103006600 active site 195103006601 DNA binding site [nucleotide binding] 195103006602 catalytic site [active] 195103006603 glutaminase A; Region: Gln_ase; TIGR03814 195103006604 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 195103006605 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 195103006606 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 195103006607 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 195103006608 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 195103006609 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 195103006610 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 195103006611 active site 195103006612 Uncharacterized conserved protein [Function unknown]; Region: COG0327 195103006613 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 195103006614 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 195103006615 Family of unknown function (DUF633); Region: DUF633; pfam04816 195103006616 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 195103006617 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 195103006618 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 195103006619 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 195103006620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103006621 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 195103006622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195103006623 DNA binding residues [nucleotide binding] 195103006624 DNA primase; Validated; Region: dnaG; PRK05667 195103006625 CHC2 zinc finger; Region: zf-CHC2; pfam01807 195103006626 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 195103006627 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 195103006628 active site 195103006629 metal binding site [ion binding]; metal-binding site 195103006630 interdomain interaction site; other site 195103006631 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 195103006632 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 195103006633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103006634 Zn2+ binding site [ion binding]; other site 195103006635 Mg2+ binding site [ion binding]; other site 195103006636 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 195103006637 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 195103006638 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 195103006639 substrate binding site [chemical binding]; other site 195103006640 pyruvate phosphate dikinase; Provisional; Region: PRK09279 195103006641 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 195103006642 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 195103006643 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 195103006644 HTH domain; Region: HTH_11; pfam08279 195103006645 FOG: CBS domain [General function prediction only]; Region: COG0517 195103006646 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 195103006647 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 195103006648 Recombination protein O N terminal; Region: RecO_N; pfam11967 195103006649 DNA repair protein RecO; Region: reco; TIGR00613 195103006650 Recombination protein O C terminal; Region: RecO_C; pfam02565 195103006651 GTPase Era; Reviewed; Region: era; PRK00089 195103006652 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 195103006653 G1 box; other site 195103006654 GTP/Mg2+ binding site [chemical binding]; other site 195103006655 Switch I region; other site 195103006656 G2 box; other site 195103006657 Switch II region; other site 195103006658 G3 box; other site 195103006659 G4 box; other site 195103006660 G5 box; other site 195103006661 KH domain; Region: KH_2; pfam07650 195103006662 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 195103006663 active site 195103006664 catalytic motif [active] 195103006665 Zn binding site [ion binding]; other site 195103006666 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 195103006667 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 195103006668 active site 195103006669 metal-binding heat shock protein; Provisional; Region: PRK00016 195103006670 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 195103006671 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 195103006672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103006673 Zn2+ binding site [ion binding]; other site 195103006674 Mg2+ binding site [ion binding]; other site 195103006675 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 195103006676 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 195103006677 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 195103006678 Yqey-like protein; Region: YqeY; pfam09424 195103006679 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 195103006680 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 195103006681 nucleotide binding site/active site [active] 195103006682 HIT family signature motif; other site 195103006683 catalytic residue [active] 195103006684 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 195103006685 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 195103006686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103006687 FeS/SAM binding site; other site 195103006688 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 195103006689 RNA methyltransferase, RsmE family; Region: TIGR00046 195103006690 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 195103006691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103006692 S-adenosylmethionine binding site [chemical binding]; other site 195103006693 Predicted transcriptional regulators [Transcription]; Region: COG1725 195103006694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103006695 DNA-binding site [nucleotide binding]; DNA binding site 195103006696 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 195103006697 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 195103006698 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 195103006699 Walker A/P-loop; other site 195103006700 ATP binding site [chemical binding]; other site 195103006701 Q-loop/lid; other site 195103006702 ABC transporter signature motif; other site 195103006703 Walker B; other site 195103006704 D-loop; other site 195103006705 H-loop/switch region; other site 195103006706 chaperone protein DnaJ; Provisional; Region: PRK14297 195103006707 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 195103006708 HSP70 interaction site [polypeptide binding]; other site 195103006709 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 195103006710 substrate binding site [polypeptide binding]; other site 195103006711 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 195103006712 Zn binding sites [ion binding]; other site 195103006713 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 195103006714 dimer interface [polypeptide binding]; other site 195103006715 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 195103006716 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 195103006717 nucleotide binding site [chemical binding]; other site 195103006718 NEF interaction site [polypeptide binding]; other site 195103006719 SBD interface [polypeptide binding]; other site 195103006720 GrpE; Region: GrpE; pfam01025 195103006721 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 195103006722 dimer interface [polypeptide binding]; other site 195103006723 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 195103006724 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 195103006725 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 195103006726 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 195103006727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103006728 FeS/SAM binding site; other site 195103006729 HemN C-terminal domain; Region: HemN_C; pfam06969 195103006730 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 195103006731 5S rRNA interface [nucleotide binding]; other site 195103006732 CTC domain interface [polypeptide binding]; other site 195103006733 L16 interface [polypeptide binding]; other site 195103006734 GTP-binding protein LepA; Provisional; Region: PRK05433 195103006735 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 195103006736 G1 box; other site 195103006737 putative GEF interaction site [polypeptide binding]; other site 195103006738 GTP/Mg2+ binding site [chemical binding]; other site 195103006739 Switch I region; other site 195103006740 G2 box; other site 195103006741 G3 box; other site 195103006742 Switch II region; other site 195103006743 G4 box; other site 195103006744 G5 box; other site 195103006745 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 195103006746 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 195103006747 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 195103006748 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 195103006749 stage II sporulation protein P; Region: spore_II_P; TIGR02867 195103006750 germination protease; Provisional; Region: PRK12362 195103006751 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 195103006752 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 195103006753 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 195103006754 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 195103006755 Competence protein; Region: Competence; pfam03772 195103006756 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 195103006757 stage V sporulation protein AD; Validated; Region: PRK08304 195103006758 stage V sporulation protein AD; Provisional; Region: PRK12404 195103006759 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 195103006760 sporulation sigma factor SigF; Validated; Region: PRK05572 195103006761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103006762 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 195103006763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 195103006764 DNA binding residues [nucleotide binding] 195103006765 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 195103006766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103006767 ATP binding site [chemical binding]; other site 195103006768 Mg2+ binding site [ion binding]; other site 195103006769 G-X-G motif; other site 195103006770 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 195103006771 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 195103006772 anti sigma factor interaction site; other site 195103006773 regulatory phosphorylation site [posttranslational modification]; other site 195103006774 AAA domain; Region: AAA_32; pfam13654 195103006775 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 195103006776 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 195103006777 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 195103006778 intersubunit interface [polypeptide binding]; other site 195103006779 active site 195103006780 catalytic residue [active] 195103006781 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 195103006782 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 195103006783 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195103006784 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 195103006785 Soluble P-type ATPase [General function prediction only]; Region: COG4087 195103006786 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 195103006787 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 195103006788 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 195103006789 DRTGG domain; Region: DRTGG; pfam07085 195103006790 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 195103006791 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 195103006792 DHHA2 domain; Region: DHHA2; pfam02833 195103006793 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 195103006794 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 195103006795 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 195103006796 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 195103006797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 195103006798 catalytic residue [active] 195103006799 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 195103006800 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 195103006801 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 195103006802 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 195103006803 dimer interface [polypeptide binding]; other site 195103006804 PYR/PP interface [polypeptide binding]; other site 195103006805 TPP binding site [chemical binding]; other site 195103006806 substrate binding site [chemical binding]; other site 195103006807 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 195103006808 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 195103006809 Domain of unknown function; Region: EKR; smart00890 195103006810 4Fe-4S binding domain; Region: Fer4_6; pfam12837 195103006811 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 195103006812 TPP-binding site [chemical binding]; other site 195103006813 dimer interface [polypeptide binding]; other site 195103006814 flavodoxin; Provisional; Region: PRK05569 195103006815 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 195103006816 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 195103006817 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 195103006818 active site 195103006819 homodimer interface [polypeptide binding]; other site 195103006820 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 195103006821 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 195103006822 DHH family; Region: DHH; pfam01368 195103006823 DHHA1 domain; Region: DHHA1; pfam02272 195103006824 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 195103006825 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 195103006826 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 195103006827 DJ-1 family protein; Region: not_thiJ; TIGR01383 195103006828 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 195103006829 conserved cys residue [active] 195103006830 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 195103006831 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 195103006832 CAP-like domain; other site 195103006833 active site 195103006834 primary dimer interface [polypeptide binding]; other site 195103006835 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 195103006836 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 195103006837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103006838 ATP binding site [chemical binding]; other site 195103006839 Mg2+ binding site [ion binding]; other site 195103006840 G-X-G motif; other site 195103006841 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 195103006842 anchoring element; other site 195103006843 dimer interface [polypeptide binding]; other site 195103006844 ATP binding site [chemical binding]; other site 195103006845 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 195103006846 active site 195103006847 metal binding site [ion binding]; metal-binding site 195103006848 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 195103006849 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 195103006850 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 195103006851 active site residue [active] 195103006852 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 195103006853 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 195103006854 DXD motif; other site 195103006855 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 195103006856 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 195103006857 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 195103006858 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 195103006859 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 195103006860 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 195103006861 inner membrane transporter YjeM; Provisional; Region: PRK15238 195103006862 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 195103006863 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 195103006864 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 195103006865 trimer interface [polypeptide binding]; other site 195103006866 active site 195103006867 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 195103006868 catalytic site [active] 195103006869 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 195103006870 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103006871 nucleotide binding site [chemical binding]; other site 195103006872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 195103006873 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 195103006874 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 195103006875 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 195103006876 active site 195103006877 catalytic site [active] 195103006878 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 195103006879 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 195103006880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 195103006881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103006882 dimer interface [polypeptide binding]; other site 195103006883 conserved gate region; other site 195103006884 ABC-ATPase subunit interface; other site 195103006885 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 195103006886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103006887 ABC-ATPase subunit interface; other site 195103006888 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 195103006889 trimer interface [polypeptide binding]; other site 195103006890 dimer interface [polypeptide binding]; other site 195103006891 putative active site [active] 195103006892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103006893 dimer interface [polypeptide binding]; other site 195103006894 conserved gate region; other site 195103006895 putative PBP binding loops; other site 195103006896 ABC-ATPase subunit interface; other site 195103006897 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 195103006898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 195103006899 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 195103006900 MPT binding site; other site 195103006901 trimer interface [polypeptide binding]; other site 195103006902 Response regulator receiver domain; Region: Response_reg; pfam00072 195103006903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103006904 active site 195103006905 phosphorylation site [posttranslational modification] 195103006906 intermolecular recognition site; other site 195103006907 dimerization interface [polypeptide binding]; other site 195103006908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 195103006909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 195103006910 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 195103006911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103006912 dimerization interface [polypeptide binding]; other site 195103006913 Histidine kinase; Region: His_kinase; pfam06580 195103006914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103006915 ATP binding site [chemical binding]; other site 195103006916 Mg2+ binding site [ion binding]; other site 195103006917 G-X-G motif; other site 195103006918 Protein of unknown function, DUF624; Region: DUF624; pfam04854 195103006919 FemAB family; Region: FemAB; pfam02388 195103006920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 195103006921 Transcriptional regulator PadR-like family; Region: PadR; cl17335 195103006922 Predicted transcriptional regulators [Transcription]; Region: COG1695 195103006923 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 195103006924 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 195103006925 Walker A/P-loop; other site 195103006926 ATP binding site [chemical binding]; other site 195103006927 Q-loop/lid; other site 195103006928 ABC transporter signature motif; other site 195103006929 Walker B; other site 195103006930 D-loop; other site 195103006931 H-loop/switch region; other site 195103006932 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 195103006933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 195103006934 substrate binding pocket [chemical binding]; other site 195103006935 membrane-bound complex binding site; other site 195103006936 hinge residues; other site 195103006937 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 195103006938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103006939 dimer interface [polypeptide binding]; other site 195103006940 conserved gate region; other site 195103006941 putative PBP binding loops; other site 195103006942 ABC-ATPase subunit interface; other site 195103006943 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 195103006944 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 195103006945 Protein of unknown function DUF86; Region: DUF86; pfam01934 195103006946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103006947 dimerization interface [polypeptide binding]; other site 195103006948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103006949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103006950 dimer interface [polypeptide binding]; other site 195103006951 phosphorylation site [posttranslational modification] 195103006952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103006953 ATP binding site [chemical binding]; other site 195103006954 Mg2+ binding site [ion binding]; other site 195103006955 G-X-G motif; other site 195103006956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103006957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103006958 active site 195103006959 phosphorylation site [posttranslational modification] 195103006960 intermolecular recognition site; other site 195103006961 dimerization interface [polypeptide binding]; other site 195103006962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103006963 DNA binding site [nucleotide binding] 195103006964 Protein of unknown function (DUF503); Region: DUF503; pfam04456 195103006965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103006966 ATP binding site [chemical binding]; other site 195103006967 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 195103006968 putative Mg++ binding site [ion binding]; other site 195103006969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103006970 nucleotide binding region [chemical binding]; other site 195103006971 ATP-binding site [chemical binding]; other site 195103006972 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 195103006973 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 195103006974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103006975 S-adenosylmethionine binding site [chemical binding]; other site 195103006976 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 195103006977 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 195103006978 trimer interface [polypeptide binding]; other site 195103006979 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 195103006980 ApbE family; Region: ApbE; pfam02424 195103006981 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 195103006982 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 195103006983 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 195103006984 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 195103006985 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 195103006986 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 195103006987 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 195103006988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 195103006989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 195103006990 putative substrate translocation pore; other site 195103006991 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 195103006992 active site 195103006993 catalytic triad [active] 195103006994 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 195103006995 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 195103006996 active site 195103006997 catalytic triad [active] 195103006998 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 195103006999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103007000 S-adenosylmethionine binding site [chemical binding]; other site 195103007001 RDD family; Region: RDD; cl00746 195103007002 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 195103007003 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 195103007004 G1 box; other site 195103007005 putative GEF interaction site [polypeptide binding]; other site 195103007006 GTP/Mg2+ binding site [chemical binding]; other site 195103007007 Switch I region; other site 195103007008 G2 box; other site 195103007009 G3 box; other site 195103007010 Switch II region; other site 195103007011 G4 box; other site 195103007012 G5 box; other site 195103007013 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 195103007014 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 195103007015 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 195103007016 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 195103007017 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 195103007018 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 195103007019 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 195103007020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103007021 catalytic residue [active] 195103007022 selenophosphate synthetase; Provisional; Region: PRK00943 195103007023 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 195103007024 dimerization interface [polypeptide binding]; other site 195103007025 putative ATP binding site [chemical binding]; other site 195103007026 SLBB domain; Region: SLBB; pfam10531 195103007027 comEA protein; Region: comE; TIGR01259 195103007028 Helix-hairpin-helix motif; Region: HHH; pfam00633 195103007029 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 195103007030 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 195103007031 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 195103007032 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 195103007033 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 195103007034 active site 195103007035 Transcriptional regulator [Transcription]; Region: LytR; COG1316 195103007036 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 195103007037 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103007038 Zn2+ binding site [ion binding]; other site 195103007039 Mg2+ binding site [ion binding]; other site 195103007040 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 195103007041 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 195103007042 active site 195103007043 (T/H)XGH motif; other site 195103007044 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 195103007045 GTPase CgtA; Reviewed; Region: obgE; PRK12297 195103007046 GTP1/OBG; Region: GTP1_OBG; pfam01018 195103007047 Obg GTPase; Region: Obg; cd01898 195103007048 G1 box; other site 195103007049 GTP/Mg2+ binding site [chemical binding]; other site 195103007050 Switch I region; other site 195103007051 G2 box; other site 195103007052 G3 box; other site 195103007053 Switch II region; other site 195103007054 G4 box; other site 195103007055 G5 box; other site 195103007056 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 195103007057 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 195103007058 hypothetical protein; Provisional; Region: PRK14553 195103007059 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 195103007060 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 195103007061 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 195103007062 homodimer interface [polypeptide binding]; other site 195103007063 oligonucleotide binding site [chemical binding]; other site 195103007064 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 195103007065 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 195103007066 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 195103007067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103007068 FeS/SAM binding site; other site 195103007069 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 195103007070 Peptidase family M50; Region: Peptidase_M50; pfam02163 195103007071 active site 195103007072 putative substrate binding region [chemical binding]; other site 195103007073 Peptidase family M23; Region: Peptidase_M23; pfam01551 195103007074 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 195103007075 cell division topological specificity factor MinE; Provisional; Region: PRK13987 195103007076 septum site-determining protein MinD; Region: minD_bact; TIGR01968 195103007077 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 195103007078 Switch I; other site 195103007079 Switch II; other site 195103007080 septum formation inhibitor; Reviewed; Region: minC; PRK00513 195103007081 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 195103007082 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 195103007083 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 195103007084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 195103007085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 195103007086 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 195103007087 rod shape-determining protein MreC; Provisional; Region: PRK13922 195103007088 rod shape-determining protein MreC; Region: MreC; pfam04085 195103007089 rod shape-determining protein MreB; Provisional; Region: PRK13927 195103007090 MreB and similar proteins; Region: MreB_like; cd10225 195103007091 nucleotide binding site [chemical binding]; other site 195103007092 Mg binding site [ion binding]; other site 195103007093 putative protofilament interaction site [polypeptide binding]; other site 195103007094 RodZ interaction site [polypeptide binding]; other site 195103007095 hypothetical protein; Reviewed; Region: PRK00024 195103007096 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 195103007097 MPN+ (JAMM) motif; other site 195103007098 Zinc-binding site [ion binding]; other site 195103007099 Maf-like protein; Reviewed; Region: PRK00078 195103007100 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 195103007101 active site 195103007102 dimer interface [polypeptide binding]; other site 195103007103 Sporulation related domain; Region: SPOR; pfam05036 195103007104 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 195103007105 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 195103007106 active site 195103007107 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 195103007108 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 195103007109 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 195103007110 metal binding site [ion binding]; metal-binding site 195103007111 dimer interface [polypeptide binding]; other site 195103007112 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 195103007113 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 195103007114 domain interfaces; other site 195103007115 active site 195103007116 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 195103007117 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 195103007118 RNA binding site [nucleotide binding]; other site 195103007119 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 195103007120 RNA binding site [nucleotide binding]; other site 195103007121 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 195103007122 RNA binding site [nucleotide binding]; other site 195103007123 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 195103007124 RNA binding site [nucleotide binding]; other site 195103007125 domain interface; other site 195103007126 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 195103007127 metal-binding site [ion binding] 195103007128 hypothetical protein; Validated; Region: PRK02101 195103007129 FOG: CBS domain [General function prediction only]; Region: COG0517 195103007130 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 195103007131 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 195103007132 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 195103007133 active site 195103007134 catalytic site [active] 195103007135 substrate binding site [chemical binding]; other site 195103007136 Protein of unknown function DUF262; Region: DUF262; pfam03235 195103007137 Uncharacterized conserved protein [Function unknown]; Region: COG1479 195103007138 Protein of unknown function DUF262; Region: DUF262; pfam03235 195103007139 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 195103007140 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 195103007141 Walker A/P-loop; other site 195103007142 ATP binding site [chemical binding]; other site 195103007143 Q-loop/lid; other site 195103007144 ABC transporter signature motif; other site 195103007145 Walker B; other site 195103007146 D-loop; other site 195103007147 H-loop/switch region; other site 195103007148 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 195103007149 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 195103007150 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 195103007151 active site turn [active] 195103007152 phosphorylation site [posttranslational modification] 195103007153 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 195103007154 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 195103007155 metal binding site [ion binding]; metal-binding site 195103007156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103007157 Walker A/P-loop; other site 195103007158 ATP binding site [chemical binding]; other site 195103007159 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 195103007160 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 195103007161 active site 195103007162 metal binding site [ion binding]; metal-binding site 195103007163 DNA binding site [nucleotide binding] 195103007164 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 195103007165 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 195103007166 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 195103007167 active site 195103007168 metal binding site [ion binding]; metal-binding site 195103007169 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 195103007170 FOG: CBS domain [General function prediction only]; Region: COG0517 195103007171 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 195103007172 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 195103007173 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 195103007174 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 195103007175 Glycoprotease family; Region: Peptidase_M22; pfam00814 195103007176 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 195103007177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 195103007178 Coenzyme A binding pocket [chemical binding]; other site 195103007179 Predicted membrane protein [Function unknown]; Region: COG3601 195103007180 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 195103007181 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 195103007182 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 195103007183 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 195103007184 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 195103007185 RNA binding site [nucleotide binding]; other site 195103007186 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 195103007187 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 195103007188 Peptidase family M28; Region: Peptidase_M28; pfam04389 195103007189 metal binding site [ion binding]; metal-binding site 195103007190 peptide chain release factor 2; Provisional; Region: PRK05589 195103007191 PCRF domain; Region: PCRF; pfam03462 195103007192 RF-1 domain; Region: RF-1; pfam00472 195103007193 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 195103007194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 195103007195 ATP binding site [chemical binding]; other site 195103007196 putative Mg++ binding site [ion binding]; other site 195103007197 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 195103007198 SEC-C motif; Region: SEC-C; pfam02810 195103007199 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 195103007200 30S subunit binding site; other site 195103007201 comF family protein; Region: comF; TIGR00201 195103007202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103007203 active site 195103007204 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 195103007205 AAA domain; Region: AAA_30; pfam13604 195103007206 Family description; Region: UvrD_C_2; pfam13538 195103007207 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 195103007208 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 195103007209 active site 195103007210 dimer interface [polypeptide binding]; other site 195103007211 S-adenosylmethionine synthetase; Validated; Region: PRK05250 195103007212 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 195103007213 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 195103007214 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 195103007215 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 195103007216 rod shape-determining protein Mbl; Provisional; Region: PRK13928 195103007217 MreB and similar proteins; Region: MreB_like; cd10225 195103007218 nucleotide binding site [chemical binding]; other site 195103007219 Mg binding site [ion binding]; other site 195103007220 putative protofilament interaction site [polypeptide binding]; other site 195103007221 RodZ interaction site [polypeptide binding]; other site 195103007222 sporulation transcriptional regulator SpoIIID; Region: spore_III_D; TIGR02844 195103007223 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195103007224 Peptidase family M23; Region: Peptidase_M23; pfam01551 195103007225 Stage II sporulation protein; Region: SpoIID; pfam08486 195103007226 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 195103007227 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 195103007228 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 195103007229 hinge; other site 195103007230 active site 195103007231 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 195103007232 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 195103007233 gamma subunit interface [polypeptide binding]; other site 195103007234 epsilon subunit interface [polypeptide binding]; other site 195103007235 LBP interface [polypeptide binding]; other site 195103007236 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 195103007237 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 195103007238 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 195103007239 alpha subunit interaction interface [polypeptide binding]; other site 195103007240 Walker A motif; other site 195103007241 ATP binding site [chemical binding]; other site 195103007242 Walker B motif; other site 195103007243 inhibitor binding site; inhibition site 195103007244 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 195103007245 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 195103007246 core domain interface [polypeptide binding]; other site 195103007247 delta subunit interface [polypeptide binding]; other site 195103007248 epsilon subunit interface [polypeptide binding]; other site 195103007249 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 195103007250 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 195103007251 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 195103007252 beta subunit interaction interface [polypeptide binding]; other site 195103007253 Walker A motif; other site 195103007254 ATP binding site [chemical binding]; other site 195103007255 Walker B motif; other site 195103007256 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 195103007257 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 195103007258 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 195103007259 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 195103007260 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 195103007261 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 195103007262 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 195103007263 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 195103007264 putative acyltransferase; Provisional; Region: PRK05790 195103007265 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 195103007266 dimer interface [polypeptide binding]; other site 195103007267 active site 195103007268 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 195103007269 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 195103007270 active site 195103007271 homodimer interface [polypeptide binding]; other site 195103007272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103007273 active site 195103007274 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 195103007275 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 195103007276 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 195103007277 peptide chain release factor 1; Validated; Region: prfA; PRK00591 195103007278 This domain is found in peptide chain release factors; Region: PCRF; smart00937 195103007279 RF-1 domain; Region: RF-1; pfam00472 195103007280 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 195103007281 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 195103007282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103007283 S-adenosylmethionine binding site [chemical binding]; other site 195103007284 thymidine kinase; Provisional; Region: PRK04296 195103007285 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 195103007286 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 195103007287 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 195103007288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 195103007289 transcription termination factor Rho; Provisional; Region: PRK12608 195103007290 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 195103007291 RNA binding site [nucleotide binding]; other site 195103007292 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 195103007293 multimer interface [polypeptide binding]; other site 195103007294 Walker A motif; other site 195103007295 ATP binding site [chemical binding]; other site 195103007296 Walker B motif; other site 195103007297 CTP synthetase; Validated; Region: pyrG; PRK05380 195103007298 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 195103007299 Catalytic site [active] 195103007300 active site 195103007301 UTP binding site [chemical binding]; other site 195103007302 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 195103007303 active site 195103007304 putative oxyanion hole; other site 195103007305 catalytic triad [active] 195103007306 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 195103007307 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 195103007308 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 195103007309 Ligand Binding Site [chemical binding]; other site 195103007310 stage II sporulation protein R; Region: spore_II_R; TIGR02837 195103007311 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 195103007312 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 195103007313 cyanophycin synthetase; Provisional; Region: PRK14016 195103007314 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195103007315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103007316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195103007317 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 195103007318 proposed catalytic triad [active] 195103007319 active site nucleophile [active] 195103007320 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 195103007321 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 195103007322 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 195103007323 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 195103007324 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 195103007325 YabG peptidase U57; Region: Peptidase_U57; pfam05582 195103007326 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 195103007327 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 195103007328 active site 195103007329 ATP binding site [chemical binding]; other site 195103007330 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 195103007331 substrate binding site [chemical binding]; other site 195103007332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103007333 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 195103007334 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 195103007335 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 195103007336 active site 195103007337 ATP binding site [chemical binding]; other site 195103007338 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 195103007339 substrate binding site [chemical binding]; other site 195103007340 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 195103007341 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 195103007342 substrate binding site [chemical binding]; other site 195103007343 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 195103007344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 195103007345 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 195103007346 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 195103007347 trimer interface [polypeptide binding]; other site 195103007348 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 195103007349 FMN-binding domain; Region: FMN_bind; cl01081 195103007350 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 195103007351 ApbE family; Region: ApbE; pfam02424 195103007352 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 195103007353 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 195103007354 active site 195103007355 P-loop; other site 195103007356 phosphorylation site [posttranslational modification] 195103007357 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 195103007358 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 195103007359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 195103007360 protein binding site [polypeptide binding]; other site 195103007361 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 195103007362 UGMP family protein; Validated; Region: PRK09604 195103007363 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 195103007364 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 195103007365 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 195103007366 active site 195103007367 catalytic triad [active] 195103007368 oxyanion hole [active] 195103007369 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 195103007370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195103007371 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 195103007372 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 195103007373 CPxP motif; other site 195103007374 DsrE/DsrF-like family; Region: DrsE; pfam02635 195103007375 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 195103007376 Sulfatase; Region: Sulfatase; pfam00884 195103007377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103007378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 195103007379 dimerization interface [polypeptide binding]; other site 195103007380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103007381 dimer interface [polypeptide binding]; other site 195103007382 phosphorylation site [posttranslational modification] 195103007383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103007384 ATP binding site [chemical binding]; other site 195103007385 Mg2+ binding site [ion binding]; other site 195103007386 G-X-G motif; other site 195103007387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103007388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103007389 active site 195103007390 phosphorylation site [posttranslational modification] 195103007391 intermolecular recognition site; other site 195103007392 dimerization interface [polypeptide binding]; other site 195103007393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103007394 DNA binding site [nucleotide binding] 195103007395 Chromate transporter; Region: Chromate_transp; pfam02417 195103007396 Chromate transporter; Region: Chromate_transp; pfam02417 195103007397 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 195103007398 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 195103007399 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 195103007400 metal binding site [ion binding]; metal-binding site 195103007401 dimer interface [polypeptide binding]; other site 195103007402 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 195103007403 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 195103007404 active site 195103007405 metal binding site [ion binding]; metal-binding site 195103007406 homotetramer interface [polypeptide binding]; other site 195103007407 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 195103007408 active site 195103007409 dimerization interface [polypeptide binding]; other site 195103007410 ribonuclease PH; Reviewed; Region: rph; PRK00173 195103007411 Ribonuclease PH; Region: RNase_PH_bact; cd11362 195103007412 hexamer interface [polypeptide binding]; other site 195103007413 active site 195103007414 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 195103007415 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 195103007416 Restriction endonuclease; Region: Mrr_cat; pfam04471 195103007417 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 195103007418 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 195103007419 nucleotide binding pocket [chemical binding]; other site 195103007420 K-X-D-G motif; other site 195103007421 catalytic site [active] 195103007422 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 195103007423 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 195103007424 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 195103007425 DNA binding site [nucleotide binding] 195103007426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 195103007427 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 195103007428 Dimer interface [polypeptide binding]; other site 195103007429 BRCT sequence motif; other site 195103007430 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 195103007431 Part of AAA domain; Region: AAA_19; pfam13245 195103007432 AAA domain; Region: AAA_14; pfam13173 195103007433 Family description; Region: UvrD_C_2; pfam13538 195103007434 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 195103007435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103007436 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 195103007437 RNA binding surface [nucleotide binding]; other site 195103007438 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 195103007439 active site 195103007440 uracil binding [chemical binding]; other site 195103007441 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 195103007442 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 195103007443 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 195103007444 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 195103007445 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 195103007446 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 195103007447 hypothetical protein; Validated; Region: PRK00124 195103007448 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 195103007449 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 195103007450 active site 195103007451 dimer interface [polypeptide binding]; other site 195103007452 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 195103007453 dimer interface [polypeptide binding]; other site 195103007454 active site 195103007455 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 195103007456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 195103007457 Walker A/P-loop; other site 195103007458 ATP binding site [chemical binding]; other site 195103007459 Q-loop/lid; other site 195103007460 ABC transporter signature motif; other site 195103007461 Walker B; other site 195103007462 D-loop; other site 195103007463 H-loop/switch region; other site 195103007464 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 195103007465 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 195103007466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 195103007467 Walker A/P-loop; other site 195103007468 ATP binding site [chemical binding]; other site 195103007469 Q-loop/lid; other site 195103007470 ABC transporter signature motif; other site 195103007471 Walker B; other site 195103007472 D-loop; other site 195103007473 H-loop/switch region; other site 195103007474 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 195103007475 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 195103007476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 195103007477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103007478 dimer interface [polypeptide binding]; other site 195103007479 conserved gate region; other site 195103007480 putative PBP binding loops; other site 195103007481 ABC-ATPase subunit interface; other site 195103007482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 195103007483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103007484 dimer interface [polypeptide binding]; other site 195103007485 conserved gate region; other site 195103007486 putative PBP binding loops; other site 195103007487 ABC-ATPase subunit interface; other site 195103007488 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 195103007489 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 195103007490 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 195103007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 195103007492 GMP synthase; Reviewed; Region: guaA; PRK00074 195103007493 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 195103007494 AMP/PPi binding site [chemical binding]; other site 195103007495 candidate oxyanion hole; other site 195103007496 catalytic triad [active] 195103007497 potential glutamine specificity residues [chemical binding]; other site 195103007498 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 195103007499 ATP Binding subdomain [chemical binding]; other site 195103007500 Ligand Binding sites [chemical binding]; other site 195103007501 Dimerization subdomain; other site 195103007502 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 195103007503 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 195103007504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 195103007505 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 195103007506 active site 195103007507 PA14 domain; Region: PA14; cl08459 195103007508 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 195103007509 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 195103007510 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 195103007511 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 195103007512 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 195103007513 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 195103007514 nucleotide binding site [chemical binding]; other site 195103007515 Cell division protein FtsA; Region: FtsA; cl17206 195103007516 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 195103007517 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 195103007518 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 195103007519 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 195103007520 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 195103007521 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 195103007522 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 195103007523 Walker A motif; other site 195103007524 ATP binding site [chemical binding]; other site 195103007525 Walker B motif; other site 195103007526 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 195103007527 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 195103007528 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 195103007529 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 195103007530 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 195103007531 ring oligomerisation interface [polypeptide binding]; other site 195103007532 ATP/Mg binding site [chemical binding]; other site 195103007533 stacking interactions; other site 195103007534 hinge regions; other site 195103007535 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 195103007536 oligomerisation interface [polypeptide binding]; other site 195103007537 mobile loop; other site 195103007538 roof hairpin; other site 195103007539 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 195103007540 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 195103007541 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 195103007542 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 195103007543 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 195103007544 minor groove reading motif; other site 195103007545 helix-hairpin-helix signature motif; other site 195103007546 substrate binding pocket [chemical binding]; other site 195103007547 active site 195103007548 C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909 195103007549 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 195103007550 Catalytic site [active] 195103007551 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 195103007552 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 195103007553 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 195103007554 Walker A/P-loop; other site 195103007555 ATP binding site [chemical binding]; other site 195103007556 Q-loop/lid; other site 195103007557 ABC transporter signature motif; other site 195103007558 Walker B; other site 195103007559 D-loop; other site 195103007560 H-loop/switch region; other site 195103007561 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 195103007562 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 195103007563 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 195103007564 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 195103007565 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 195103007566 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 195103007567 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 195103007568 Ligand binding site [chemical binding]; other site 195103007569 Electron transfer flavoprotein domain; Region: ETF; pfam01012 195103007570 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 195103007571 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 195103007572 FAD binding site [chemical binding]; other site 195103007573 homotetramer interface [polypeptide binding]; other site 195103007574 substrate binding pocket [chemical binding]; other site 195103007575 catalytic base [active] 195103007576 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 195103007577 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 195103007578 substrate binding site [chemical binding]; other site 195103007579 oxyanion hole (OAH) forming residues; other site 195103007580 trimer interface [polypeptide binding]; other site 195103007581 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 195103007582 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 195103007583 CoA binding domain; Region: CoA_binding; pfam02629 195103007584 Heavy-metal-associated domain; Region: HMA; pfam00403 195103007585 metal-binding site [ion binding] 195103007586 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 195103007587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 195103007588 Soluble P-type ATPase [General function prediction only]; Region: COG4087 195103007589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 195103007590 dimerization interface [polypeptide binding]; other site 195103007591 putative DNA binding site [nucleotide binding]; other site 195103007592 putative Zn2+ binding site [ion binding]; other site 195103007593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103007594 DNA-binding site [nucleotide binding]; DNA binding site 195103007595 TrkA-C domain; Region: TrkA_C; pfam02080 195103007596 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 195103007597 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 195103007598 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 195103007599 Cupin domain; Region: Cupin_2; cl17218 195103007600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103007601 non-specific DNA binding site [nucleotide binding]; other site 195103007602 salt bridge; other site 195103007603 sequence-specific DNA binding site [nucleotide binding]; other site 195103007604 Protein of unknown function DUF45; Region: DUF45; pfam01863 195103007605 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 195103007606 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 195103007607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103007608 ATP binding site [chemical binding]; other site 195103007609 putative Mg++ binding site [ion binding]; other site 195103007610 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 195103007611 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 195103007612 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 195103007613 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 195103007614 HsdM N-terminal domain; Region: HsdM_N; pfam12161 195103007615 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 195103007616 Methyltransferase domain; Region: Methyltransf_26; pfam13659 195103007617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103007618 non-specific DNA binding site [nucleotide binding]; other site 195103007619 salt bridge; other site 195103007620 sequence-specific DNA binding site [nucleotide binding]; other site 195103007621 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 195103007622 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 195103007623 catalytic residues [active] 195103007624 catalytic nucleophile [active] 195103007625 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 195103007626 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 195103007627 catalytic residues [active] 195103007628 catalytic nucleophile [active] 195103007629 Recombinase; Region: Recombinase; pfam07508 195103007630 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 195103007631 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 195103007632 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 195103007633 catalytic residues [active] 195103007634 catalytic nucleophile [active] 195103007635 Presynaptic Site I dimer interface [polypeptide binding]; other site 195103007636 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 195103007637 Synaptic Flat tetramer interface [polypeptide binding]; other site 195103007638 Synaptic Site I dimer interface [polypeptide binding]; other site 195103007639 DNA binding site [nucleotide binding] 195103007640 Recombinase; Region: Recombinase; pfam07508 195103007641 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 195103007642 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 195103007643 active site 195103007644 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 195103007645 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 195103007646 Substrate binding site; other site 195103007647 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 195103007648 beta-galactosidase; Region: BGL; TIGR03356 195103007649 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 195103007650 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 195103007651 NAD(P) binding site [chemical binding]; other site 195103007652 catalytic residues [active] 195103007653 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 195103007654 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 195103007655 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 195103007656 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 195103007657 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 195103007658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103007659 RNA binding surface [nucleotide binding]; other site 195103007660 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 195103007661 probable active site [active] 195103007662 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 195103007663 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 195103007664 active site 195103007665 catalytic site [active] 195103007666 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 195103007667 homotrimer interaction site [polypeptide binding]; other site 195103007668 zinc binding site [ion binding]; other site 195103007669 CDP-binding sites; other site 195103007670 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 195103007671 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 195103007672 dimer interface [polypeptide binding]; other site 195103007673 pyridoxal binding site [chemical binding]; other site 195103007674 ATP binding site [chemical binding]; other site 195103007675 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 195103007676 active site 195103007677 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 195103007678 active site 195103007679 catalytic triad [active] 195103007680 oxyanion hole [active] 195103007681 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 195103007682 active site 195103007683 catalytic triad [active] 195103007684 oxyanion hole [active] 195103007685 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 195103007686 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 195103007687 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 195103007688 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 195103007689 active site 195103007690 dimer interface [polypeptide binding]; other site 195103007691 motif 1; other site 195103007692 motif 2; other site 195103007693 motif 3; other site 195103007694 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 195103007695 anticodon binding site; other site 195103007696 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 195103007697 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 195103007698 active site 195103007699 Zn binding site [ion binding]; other site 195103007700 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 195103007701 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 195103007702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103007703 S-adenosylmethionine binding site [chemical binding]; other site 195103007704 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 195103007705 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 195103007706 glutaminase active site [active] 195103007707 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 195103007708 dimer interface [polypeptide binding]; other site 195103007709 active site 195103007710 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 195103007711 dimer interface [polypeptide binding]; other site 195103007712 active site 195103007713 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 195103007714 dinuclear metal binding motif [ion binding]; other site 195103007715 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 195103007716 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 195103007717 active site 195103007718 substrate binding site [chemical binding]; other site 195103007719 metal binding site [ion binding]; metal-binding site 195103007720 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 195103007721 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 195103007722 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 195103007723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 195103007724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103007725 dimer interface [polypeptide binding]; other site 195103007726 phosphorylation site [posttranslational modification] 195103007727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103007728 ATP binding site [chemical binding]; other site 195103007729 Mg2+ binding site [ion binding]; other site 195103007730 G-X-G motif; other site 195103007731 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 195103007732 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 195103007733 Trp repressor protein; Region: Trp_repressor; cl17266 195103007734 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 195103007735 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 195103007736 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 195103007737 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 195103007738 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 195103007739 homodimer interface [polypeptide binding]; other site 195103007740 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 195103007741 active site pocket [active] 195103007742 4-alpha-glucanotransferase; Provisional; Region: PRK14508 195103007743 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 195103007744 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 195103007745 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 195103007746 trimer interface [polypeptide binding]; other site 195103007747 active site 195103007748 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 195103007749 catalytic site [active] 195103007750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103007751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103007752 DNA binding site [nucleotide binding] 195103007753 domain linker motif; other site 195103007754 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 195103007755 dimerization interface [polypeptide binding]; other site 195103007756 ligand binding site [chemical binding]; other site 195103007757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 195103007758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103007759 dimer interface [polypeptide binding]; other site 195103007760 conserved gate region; other site 195103007761 putative PBP binding loops; other site 195103007762 ABC-ATPase subunit interface; other site 195103007763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 195103007764 dimer interface [polypeptide binding]; other site 195103007765 conserved gate region; other site 195103007766 ABC-ATPase subunit interface; other site 195103007767 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 195103007768 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 195103007769 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 195103007770 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 195103007771 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 195103007772 Walker A/P-loop; other site 195103007773 ATP binding site [chemical binding]; other site 195103007774 Q-loop/lid; other site 195103007775 ABC transporter signature motif; other site 195103007776 Walker B; other site 195103007777 D-loop; other site 195103007778 H-loop/switch region; other site 195103007779 TOBE domain; Region: TOBE; pfam03459 195103007780 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 195103007781 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 195103007782 catalytic loop [active] 195103007783 iron binding site [ion binding]; other site 195103007784 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 195103007785 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 195103007786 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 195103007787 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 195103007788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103007789 nucleotide binding site [chemical binding]; other site 195103007790 Acetokinase family; Region: Acetate_kinase; cl17229 195103007791 phosphate butyryltransferase; Validated; Region: PRK05805 195103007792 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 195103007793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 195103007794 YbbR-like protein; Region: YbbR; pfam07949 195103007795 TIGR00159 family protein; Region: TIGR00159 195103007796 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 195103007797 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 195103007798 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 195103007799 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 195103007800 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 195103007801 catalytic residues [active] 195103007802 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 195103007803 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 195103007804 dimer interface [polypeptide binding]; other site 195103007805 active site 195103007806 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 195103007807 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 195103007808 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 195103007809 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 195103007810 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 195103007811 dimerization domain swap beta strand [polypeptide binding]; other site 195103007812 regulatory protein interface [polypeptide binding]; other site 195103007813 active site 195103007814 regulatory phosphorylation site [posttranslational modification]; other site 195103007815 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 195103007816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 195103007817 putative active site [active] 195103007818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103007819 Walker A motif; other site 195103007820 ATP binding site [chemical binding]; other site 195103007821 Walker B motif; other site 195103007822 arginine finger; other site 195103007823 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 195103007824 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 195103007825 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 195103007826 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103007827 RNA binding surface [nucleotide binding]; other site 195103007828 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 195103007829 dimer interface [polypeptide binding]; other site 195103007830 putative radical transfer pathway; other site 195103007831 diiron center [ion binding]; other site 195103007832 tyrosyl radical; other site 195103007833 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 195103007834 Class I ribonucleotide reductase; Region: RNR_I; cd01679 195103007835 active site 195103007836 dimer interface [polypeptide binding]; other site 195103007837 catalytic residues [active] 195103007838 effector binding site; other site 195103007839 R2 peptide binding site; other site 195103007840 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 195103007841 ArsC family; Region: ArsC; pfam03960 195103007842 putative ArsC-like catalytic residues; other site 195103007843 putative TRX-like catalytic residues [active] 195103007844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 195103007845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 195103007846 dimer interface [polypeptide binding]; other site 195103007847 phosphorylation site [posttranslational modification] 195103007848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 195103007849 ATP binding site [chemical binding]; other site 195103007850 Mg2+ binding site [ion binding]; other site 195103007851 G-X-G motif; other site 195103007852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103007853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103007854 active site 195103007855 phosphorylation site [posttranslational modification] 195103007856 intermolecular recognition site; other site 195103007857 dimerization interface [polypeptide binding]; other site 195103007858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103007859 DNA binding site [nucleotide binding] 195103007860 Uncharacterized conserved protein [Function unknown]; Region: COG1284 195103007861 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103007862 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 195103007863 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 195103007864 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 195103007865 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 195103007866 active site 195103007867 metal binding site [ion binding]; metal-binding site 195103007868 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 195103007869 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 195103007870 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 195103007871 PhoU domain; Region: PhoU; pfam01895 195103007872 PhoU domain; Region: PhoU; pfam01895 195103007873 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 195103007874 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 195103007875 23S rRNA interface [nucleotide binding]; other site 195103007876 L3 interface [polypeptide binding]; other site 195103007877 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 195103007878 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 195103007879 dimerization interface 3.5A [polypeptide binding]; other site 195103007880 active site 195103007881 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 195103007882 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 195103007883 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 195103007884 Walker A/P-loop; other site 195103007885 ATP binding site [chemical binding]; other site 195103007886 Q-loop/lid; other site 195103007887 ABC transporter signature motif; other site 195103007888 Walker B; other site 195103007889 D-loop; other site 195103007890 H-loop/switch region; other site 195103007891 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 195103007892 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 195103007893 Walker A/P-loop; other site 195103007894 ATP binding site [chemical binding]; other site 195103007895 Q-loop/lid; other site 195103007896 ABC transporter signature motif; other site 195103007897 Walker B; other site 195103007898 D-loop; other site 195103007899 H-loop/switch region; other site 195103007900 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 195103007901 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 195103007902 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 195103007903 alphaNTD homodimer interface [polypeptide binding]; other site 195103007904 alphaNTD - beta interaction site [polypeptide binding]; other site 195103007905 alphaNTD - beta' interaction site [polypeptide binding]; other site 195103007906 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 195103007907 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 195103007908 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 195103007909 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103007910 RNA binding surface [nucleotide binding]; other site 195103007911 30S ribosomal protein S11; Validated; Region: PRK05309 195103007912 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 195103007913 30S ribosomal protein S13; Region: bact_S13; TIGR03631 195103007914 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 195103007915 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 195103007916 rRNA binding site [nucleotide binding]; other site 195103007917 predicted 30S ribosome binding site; other site 195103007918 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 195103007919 RNA binding site [nucleotide binding]; other site 195103007920 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 195103007921 active site 195103007922 adenylate kinase; Reviewed; Region: adk; PRK00279 195103007923 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 195103007924 AMP-binding site [chemical binding]; other site 195103007925 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 195103007926 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 195103007927 SecY translocase; Region: SecY; pfam00344 195103007928 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 195103007929 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 195103007930 23S rRNA binding site [nucleotide binding]; other site 195103007931 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 195103007932 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 195103007933 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 195103007934 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 195103007935 5S rRNA interface [nucleotide binding]; other site 195103007936 L27 interface [polypeptide binding]; other site 195103007937 23S rRNA interface [nucleotide binding]; other site 195103007938 L5 interface [polypeptide binding]; other site 195103007939 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 195103007940 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 195103007941 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 195103007942 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 195103007943 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 195103007944 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 195103007945 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 195103007946 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 195103007947 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 195103007948 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 195103007949 RNA binding site [nucleotide binding]; other site 195103007950 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 195103007951 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 195103007952 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 195103007953 23S rRNA interface [nucleotide binding]; other site 195103007954 putative translocon interaction site; other site 195103007955 signal recognition particle (SRP54) interaction site; other site 195103007956 L23 interface [polypeptide binding]; other site 195103007957 trigger factor interaction site; other site 195103007958 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 195103007959 23S rRNA interface [nucleotide binding]; other site 195103007960 5S rRNA interface [nucleotide binding]; other site 195103007961 putative antibiotic binding site [chemical binding]; other site 195103007962 L25 interface [polypeptide binding]; other site 195103007963 L27 interface [polypeptide binding]; other site 195103007964 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 195103007965 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 195103007966 G-X-X-G motif; other site 195103007967 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 195103007968 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 195103007969 putative translocon binding site; other site 195103007970 protein-rRNA interface [nucleotide binding]; other site 195103007971 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 195103007972 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 195103007973 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 195103007974 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 195103007975 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 195103007976 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 195103007977 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 195103007978 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 195103007979 elongation factor Tu; Reviewed; Region: PRK00049 195103007980 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 195103007981 G1 box; other site 195103007982 GEF interaction site [polypeptide binding]; other site 195103007983 GTP/Mg2+ binding site [chemical binding]; other site 195103007984 Switch I region; other site 195103007985 G2 box; other site 195103007986 G3 box; other site 195103007987 Switch II region; other site 195103007988 G4 box; other site 195103007989 G5 box; other site 195103007990 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 195103007991 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 195103007992 Antibiotic Binding Site [chemical binding]; other site 195103007993 elongation factor G; Reviewed; Region: PRK00007 195103007994 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 195103007995 G1 box; other site 195103007996 putative GEF interaction site [polypeptide binding]; other site 195103007997 GTP/Mg2+ binding site [chemical binding]; other site 195103007998 Switch I region; other site 195103007999 G2 box; other site 195103008000 G3 box; other site 195103008001 Switch II region; other site 195103008002 G4 box; other site 195103008003 G5 box; other site 195103008004 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 195103008005 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 195103008006 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 195103008007 30S ribosomal protein S7; Validated; Region: PRK05302 195103008008 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 195103008009 S17 interaction site [polypeptide binding]; other site 195103008010 S8 interaction site; other site 195103008011 16S rRNA interaction site [nucleotide binding]; other site 195103008012 streptomycin interaction site [chemical binding]; other site 195103008013 23S rRNA interaction site [nucleotide binding]; other site 195103008014 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 195103008015 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 195103008016 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 195103008017 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 195103008018 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 195103008019 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 195103008020 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 195103008021 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 195103008022 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 195103008023 G-loop; other site 195103008024 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 195103008025 DNA binding site [nucleotide binding] 195103008026 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 195103008027 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 195103008028 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 195103008029 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 195103008030 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 195103008031 RPB1 interaction site [polypeptide binding]; other site 195103008032 RPB10 interaction site [polypeptide binding]; other site 195103008033 RPB11 interaction site [polypeptide binding]; other site 195103008034 RPB3 interaction site [polypeptide binding]; other site 195103008035 RPB12 interaction site [polypeptide binding]; other site 195103008036 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 195103008037 core dimer interface [polypeptide binding]; other site 195103008038 peripheral dimer interface [polypeptide binding]; other site 195103008039 L10 interface [polypeptide binding]; other site 195103008040 L11 interface [polypeptide binding]; other site 195103008041 putative EF-Tu interaction site [polypeptide binding]; other site 195103008042 putative EF-G interaction site [polypeptide binding]; other site 195103008043 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 195103008044 23S rRNA interface [nucleotide binding]; other site 195103008045 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 195103008046 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 195103008047 mRNA/rRNA interface [nucleotide binding]; other site 195103008048 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 195103008049 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 195103008050 23S rRNA interface [nucleotide binding]; other site 195103008051 L7/L12 interface [polypeptide binding]; other site 195103008052 putative thiostrepton binding site; other site 195103008053 L25 interface [polypeptide binding]; other site 195103008054 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 195103008055 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 195103008056 putative homodimer interface [polypeptide binding]; other site 195103008057 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 195103008058 heterodimer interface [polypeptide binding]; other site 195103008059 homodimer interface [polypeptide binding]; other site 195103008060 preprotein translocase, SecE subunit, bacterial; Region: secE_bact; TIGR00964 195103008061 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 195103008062 elongation factor Tu; Reviewed; Region: PRK00049 195103008063 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 195103008064 G1 box; other site 195103008065 GEF interaction site [polypeptide binding]; other site 195103008066 GTP/Mg2+ binding site [chemical binding]; other site 195103008067 Switch I region; other site 195103008068 G2 box; other site 195103008069 G3 box; other site 195103008070 Switch II region; other site 195103008071 G4 box; other site 195103008072 G5 box; other site 195103008073 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 195103008074 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 195103008075 Antibiotic Binding Site [chemical binding]; other site 195103008076 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 195103008077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 195103008078 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 195103008079 YacP-like NYN domain; Region: NYN_YacP; pfam05991 195103008080 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 195103008081 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 195103008082 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 195103008083 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 195103008084 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 195103008085 dimerization interface [polypeptide binding]; other site 195103008086 active site 195103008087 metal binding site [ion binding]; metal-binding site 195103008088 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 195103008089 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 195103008090 active site 195103008091 HIGH motif; other site 195103008092 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 195103008093 KMSKS motif; other site 195103008094 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 195103008095 tRNA binding surface [nucleotide binding]; other site 195103008096 anticodon binding site; other site 195103008097 prolyl-tRNA synthetase; Provisional; Region: PRK09194 195103008098 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 195103008099 dimer interface [polypeptide binding]; other site 195103008100 motif 1; other site 195103008101 active site 195103008102 motif 2; other site 195103008103 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 195103008104 putative deacylase active site [active] 195103008105 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 195103008106 active site 195103008107 motif 3; other site 195103008108 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 195103008109 anticodon binding site; other site 195103008110 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 195103008111 substrate binding site; other site 195103008112 dimer interface; other site 195103008113 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 195103008114 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 195103008115 putative active site [active] 195103008116 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 195103008117 DNA repair protein RadA; Provisional; Region: PRK11823 195103008118 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 195103008119 Walker A motif/ATP binding site; other site 195103008120 ATP binding site [chemical binding]; other site 195103008121 Walker B motif; other site 195103008122 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 195103008123 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 195103008124 active site 195103008125 trimer interface [polypeptide binding]; other site 195103008126 allosteric site; other site 195103008127 active site lid [active] 195103008128 hexamer (dimer of trimers) interface [polypeptide binding]; other site 195103008129 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 195103008130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103008131 DNA-binding site [nucleotide binding]; DNA binding site 195103008132 UTRA domain; Region: UTRA; pfam07702 195103008133 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 195103008134 catalytic residues [active] 195103008135 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 195103008136 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 195103008137 tetrameric interface [polypeptide binding]; other site 195103008138 activator binding site; other site 195103008139 NADP binding site [chemical binding]; other site 195103008140 substrate binding site [chemical binding]; other site 195103008141 catalytic residues [active] 195103008142 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 195103008143 catalytic residues [active] 195103008144 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 195103008145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195103008146 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 195103008147 Clp amino terminal domain; Region: Clp_N; pfam02861 195103008148 Clp amino terminal domain; Region: Clp_N; pfam02861 195103008149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103008150 Walker A motif; other site 195103008151 ATP binding site [chemical binding]; other site 195103008152 Walker B motif; other site 195103008153 arginine finger; other site 195103008154 UvrB/uvrC motif; Region: UVR; pfam02151 195103008155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103008156 Walker A motif; other site 195103008157 ATP binding site [chemical binding]; other site 195103008158 Walker B motif; other site 195103008159 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 195103008160 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 195103008161 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 195103008162 ADP binding site [chemical binding]; other site 195103008163 phosphagen binding site; other site 195103008164 substrate specificity loop; other site 195103008165 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 195103008166 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 195103008167 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 195103008168 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 195103008169 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103008170 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195103008171 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195103008172 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 195103008173 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 195103008174 DNA polymerase III subunit delta'; Validated; Region: PRK05564 195103008175 DNA polymerase III subunit delta'; Validated; Region: PRK08485 195103008176 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 195103008177 Protein of unknown function (DUF970); Region: DUF970; pfam06153 195103008178 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 195103008179 AAA domain; Region: AAA_18; pfam13238 195103008180 catalytic site [active] 195103008181 G-X2-G-X-G-K; other site 195103008182 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 195103008183 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 195103008184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103008185 catalytic residue [active] 195103008186 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 195103008187 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 195103008188 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 195103008189 amidohydrolase; Region: amidohydrolases; TIGR01891 195103008190 metal binding site [ion binding]; metal-binding site 195103008191 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 195103008192 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 195103008193 Cl binding site [ion binding]; other site 195103008194 oligomer interface [polypeptide binding]; other site 195103008195 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 195103008196 dimer interface [polypeptide binding]; other site 195103008197 catalytic triad [active] 195103008198 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 195103008199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103008200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195103008201 biotin synthase; Provisional; Region: PRK07094 195103008202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103008203 FeS/SAM binding site; other site 195103008204 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 195103008205 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 195103008206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195103008207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195103008208 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 195103008209 putative dimer interface [polypeptide binding]; other site 195103008210 catalytic triad [active] 195103008211 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 195103008212 peptidase T-like protein; Region: PepT-like; TIGR01883 195103008213 metal binding site [ion binding]; metal-binding site 195103008214 putative dimer interface [polypeptide binding]; other site 195103008215 glycyl-tRNA synthetase; Provisional; Region: PRK04173 195103008216 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 195103008217 motif 1; other site 195103008218 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 195103008219 active site 195103008220 motif 2; other site 195103008221 motif 3; other site 195103008222 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 195103008223 anticodon binding site; other site 195103008224 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 195103008225 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 195103008226 dimer interface [polypeptide binding]; other site 195103008227 putative anticodon binding site; other site 195103008228 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 195103008229 motif 1; other site 195103008230 active site 195103008231 motif 2; other site 195103008232 motif 3; other site 195103008233 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 195103008234 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 195103008235 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 195103008236 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 195103008237 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 195103008238 FMN binding site [chemical binding]; other site 195103008239 active site 195103008240 catalytic residues [active] 195103008241 substrate binding site [chemical binding]; other site 195103008242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 195103008243 nucleotide binding site [chemical binding]; other site 195103008244 Type III pantothenate kinase; Region: Pan_kinase; cl17198 195103008245 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 195103008246 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 195103008247 Potassium binding sites [ion binding]; other site 195103008248 Cesium cation binding sites [ion binding]; other site 195103008249 FtsH Extracellular; Region: FtsH_ext; pfam06480 195103008250 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 195103008251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103008252 Walker A motif; other site 195103008253 ATP binding site [chemical binding]; other site 195103008254 Walker B motif; other site 195103008255 arginine finger; other site 195103008256 Peptidase family M41; Region: Peptidase_M41; pfam01434 195103008257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103008258 active site 195103008259 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 195103008260 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 195103008261 Ligand Binding Site [chemical binding]; other site 195103008262 TilS substrate C-terminal domain; Region: TilS_C; smart00977 195103008263 stage II sporulation protein E; Region: spore_II_E; TIGR02865 195103008264 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 195103008265 hypothetical protein; Provisional; Region: PRK05807 195103008266 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 195103008267 RNA binding site [nucleotide binding]; other site 195103008268 Septum formation initiator; Region: DivIC; pfam04977 195103008269 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 195103008270 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 195103008271 sporulation protein YabP; Region: spore_yabP; TIGR02892 195103008272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 195103008273 RNA binding surface [nucleotide binding]; other site 195103008274 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 195103008275 IHF dimer interface [polypeptide binding]; other site 195103008276 IHF - DNA interface [nucleotide binding]; other site 195103008277 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 195103008278 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 195103008279 putative SAM binding site [chemical binding]; other site 195103008280 putative homodimer interface [polypeptide binding]; other site 195103008281 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 195103008282 homodimer interface [polypeptide binding]; other site 195103008283 metal binding site [ion binding]; metal-binding site 195103008284 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 195103008285 homodimer interface [polypeptide binding]; other site 195103008286 active site 195103008287 putative chemical substrate binding site [chemical binding]; other site 195103008288 metal binding site [ion binding]; metal-binding site 195103008289 stage V sporulation protein B; Region: spore_V_B; TIGR02900 195103008290 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 195103008291 stage V sporulation protein T; Region: spore_V_T; TIGR02851 195103008292 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 195103008293 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 195103008294 SurA N-terminal domain; Region: SurA_N_3; cl07813 195103008295 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 195103008296 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 195103008297 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 195103008298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 195103008299 ATP binding site [chemical binding]; other site 195103008300 putative Mg++ binding site [ion binding]; other site 195103008301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 195103008302 nucleotide binding region [chemical binding]; other site 195103008303 ATP-binding site [chemical binding]; other site 195103008304 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 195103008305 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 195103008306 putative active site [active] 195103008307 catalytic residue [active] 195103008308 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 195103008309 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 195103008310 protein binding site [polypeptide binding]; other site 195103008311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 195103008312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 195103008313 active site 195103008314 phosphorylation site [posttranslational modification] 195103008315 intermolecular recognition site; other site 195103008316 dimerization interface [polypeptide binding]; other site 195103008317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 195103008318 DNA binding site [nucleotide binding] 195103008319 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 195103008320 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 195103008321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103008322 active site 195103008323 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 195103008324 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 195103008325 Substrate binding site; other site 195103008326 Mg++ binding site; other site 195103008327 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 195103008328 active site 195103008329 substrate binding site [chemical binding]; other site 195103008330 CoA binding site [chemical binding]; other site 195103008331 regulatory protein SpoVG; Reviewed; Region: PRK13259 195103008332 pur operon repressor, Bacillus subtilis type; Region: purR_Bsub; TIGR01743 195103008333 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 195103008334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 195103008335 active site 195103008336 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 195103008337 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 195103008338 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 195103008339 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 195103008340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103008341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103008342 DNA binding site [nucleotide binding] 195103008343 domain linker motif; other site 195103008344 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 195103008345 dimerization interface [polypeptide binding]; other site 195103008346 ligand binding site [chemical binding]; other site 195103008347 purine nucleoside phosphorylase; Provisional; Region: PRK08202 195103008348 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 195103008349 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 195103008350 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 195103008351 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 195103008352 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 195103008353 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 195103008354 active site 195103008355 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 195103008356 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 195103008357 active site 195103008358 metal binding site [ion binding]; metal-binding site 195103008359 homotetramer interface [polypeptide binding]; other site 195103008360 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 195103008361 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 195103008362 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 195103008363 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 195103008364 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 195103008365 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 195103008366 putative dimer interface [polypeptide binding]; other site 195103008367 putative anticodon binding site; other site 195103008368 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 195103008369 homodimer interface [polypeptide binding]; other site 195103008370 motif 1; other site 195103008371 motif 2; other site 195103008372 active site 195103008373 motif 3; other site 195103008374 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 195103008375 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 195103008376 interface (dimer of trimers) [polypeptide binding]; other site 195103008377 Substrate-binding/catalytic site; other site 195103008378 Zn-binding sites [ion binding]; other site 195103008379 YcxB-like protein; Region: YcxB; pfam14317 195103008380 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 195103008381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 195103008382 FeS/SAM binding site; other site 195103008383 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 195103008384 Zn2+ binding site [ion binding]; other site 195103008385 Mg2+ binding site [ion binding]; other site 195103008386 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103008387 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 195103008388 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 195103008389 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 195103008390 active site 195103008391 purine riboside binding site [chemical binding]; other site 195103008392 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 195103008393 ATP cone domain; Region: ATP-cone; pfam03477 195103008394 Class III ribonucleotide reductase; Region: RNR_III; cd01675 195103008395 effector binding site; other site 195103008396 active site 195103008397 Zn binding site [ion binding]; other site 195103008398 glycine loop; other site 195103008399 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 195103008400 EDD domain protein, DegV family; Region: DegV; TIGR00762 195103008401 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 195103008402 Predicted transcriptional regulators [Transcription]; Region: COG1695 195103008403 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 195103008404 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 195103008405 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 195103008406 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 195103008407 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 195103008408 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 195103008409 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 195103008410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103008411 S-adenosylmethionine binding site [chemical binding]; other site 195103008412 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 195103008413 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 195103008414 putative active site [active] 195103008415 putative metal binding site [ion binding]; other site 195103008416 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 195103008417 Domain of unknown function (DUF348); Region: DUF348; pfam03990 195103008418 Domain of unknown function (DUF348); Region: DUF348; pfam03990 195103008419 G5 domain; Region: G5; pfam07501 195103008420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 195103008421 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 195103008422 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 195103008423 active site 195103008424 Protein of unknown function (DUF445); Region: DUF445; pfam04286 195103008425 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 195103008426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 195103008427 ligand binding site [chemical binding]; other site 195103008428 flexible hinge region; other site 195103008429 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 195103008430 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 195103008431 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 195103008432 active site 195103008433 HIGH motif; other site 195103008434 KMSKS motif; other site 195103008435 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 195103008436 tRNA binding surface [nucleotide binding]; other site 195103008437 anticodon binding site; other site 195103008438 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 195103008439 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 195103008440 HIGH motif; other site 195103008441 active site 195103008442 KMSKS motif; other site 195103008443 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 195103008444 tRNA binding surface [nucleotide binding]; other site 195103008445 anticodon binding site; other site 195103008446 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 195103008447 dimer interface [polypeptide binding]; other site 195103008448 putative tRNA-binding site [nucleotide binding]; other site 195103008449 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 195103008450 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 195103008451 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 195103008452 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 195103008453 ABC1 family; Region: ABC1; cl17513 195103008454 Uncharacterized conserved protein [Function unknown]; Region: COG3937 195103008455 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 195103008456 proline aminopeptidase P II; Provisional; Region: PRK10879 195103008457 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 195103008458 active site 195103008459 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 195103008460 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 195103008461 putative catalytic cysteine [active] 195103008462 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 195103008463 putative active site [active] 195103008464 metal binding site [ion binding]; metal-binding site 195103008465 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 195103008466 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 195103008467 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 195103008468 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 195103008469 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 195103008470 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 195103008471 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 195103008472 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 195103008473 catalytic residues [active] 195103008474 Transcriptional regulators [Transcription]; Region: PurR; COG1609 195103008475 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 195103008476 DNA binding site [nucleotide binding] 195103008477 domain linker motif; other site 195103008478 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 195103008479 dimerization interface [polypeptide binding]; other site 195103008480 ligand binding site [chemical binding]; other site 195103008481 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 195103008482 active site residue [active] 195103008483 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 195103008484 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 195103008485 HIGH motif; other site 195103008486 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 195103008487 active site 195103008488 KMSKS motif; other site 195103008489 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 195103008490 tRNA binding surface [nucleotide binding]; other site 195103008491 anticodon binding site; other site 195103008492 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 195103008493 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 195103008494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 195103008495 Walker A/P-loop; other site 195103008496 ATP binding site [chemical binding]; other site 195103008497 Q-loop/lid; other site 195103008498 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103008499 ABC transporter signature motif; other site 195103008500 Walker B; other site 195103008501 D-loop; other site 195103008502 ABC transporter; Region: ABC_tran_2; pfam12848 195103008503 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 195103008504 putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357 195103008505 Putative transcription activator [Transcription]; Region: TenA; COG0819 195103008506 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 195103008507 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 195103008508 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 195103008509 putative RNA binding site [nucleotide binding]; other site 195103008510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103008511 S-adenosylmethionine binding site [chemical binding]; other site 195103008512 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 195103008513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 195103008514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 195103008515 Predicted dehydrogenase [General function prediction only]; Region: COG0579 195103008516 hydroxyglutarate oxidase; Provisional; Region: PRK11728 195103008517 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 195103008518 glycerol kinase; Provisional; Region: glpK; PRK00047 195103008519 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 195103008520 N- and C-terminal domain interface [polypeptide binding]; other site 195103008521 active site 195103008522 MgATP binding site [chemical binding]; other site 195103008523 catalytic site [active] 195103008524 metal binding site [ion binding]; metal-binding site 195103008525 glycerol binding site [chemical binding]; other site 195103008526 homotetramer interface [polypeptide binding]; other site 195103008527 homodimer interface [polypeptide binding]; other site 195103008528 FBP binding site [chemical binding]; other site 195103008529 protein IIAGlc interface [polypeptide binding]; other site 195103008530 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 195103008531 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 195103008532 amphipathic channel; other site 195103008533 Asn-Pro-Ala signature motifs; other site 195103008534 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 195103008535 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 195103008536 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 195103008537 Uncharacterized membrane protein [Function unknown]; Region: COG3949 195103008538 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 195103008539 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 195103008540 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 195103008541 active site 195103008542 catalytic triad [active] 195103008543 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 195103008544 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 195103008545 active site 195103008546 catalytic triad [active] 195103008547 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 195103008548 active site 195103008549 catalytic triad [active] 195103008550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 195103008551 non-specific DNA binding site [nucleotide binding]; other site 195103008552 salt bridge; other site 195103008553 sequence-specific DNA binding site [nucleotide binding]; other site 195103008554 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 195103008555 Catalytic site [active] 195103008556 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 195103008557 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 195103008558 active site 195103008559 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 195103008560 glutamate racemase; Provisional; Region: PRK00865 195103008561 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 195103008562 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 195103008563 VanZ like family; Region: VanZ; cl01971 195103008564 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 195103008565 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 195103008566 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 195103008567 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 195103008568 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 195103008569 ATP-grasp domain; Region: ATP-grasp_4; cl17255 195103008570 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 195103008571 IMP binding site; other site 195103008572 dimer interface [polypeptide binding]; other site 195103008573 interdomain contacts; other site 195103008574 partial ornithine binding site; other site 195103008575 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 195103008576 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 195103008577 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 195103008578 catalytic site [active] 195103008579 subunit interface [polypeptide binding]; other site 195103008580 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 195103008581 4Fe-4S binding domain; Region: Fer4; pfam00037 195103008582 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 195103008583 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 195103008584 active site 195103008585 DNA binding site [nucleotide binding] 195103008586 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 195103008587 methionine cluster; other site 195103008588 active site 195103008589 phosphorylation site [posttranslational modification] 195103008590 metal binding site [ion binding]; metal-binding site 195103008591 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 195103008592 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 195103008593 putative catalytic cysteine [active] 195103008594 gamma-glutamyl kinase; Provisional; Region: PRK05429 195103008595 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 195103008596 nucleotide binding site [chemical binding]; other site 195103008597 homotetrameric interface [polypeptide binding]; other site 195103008598 putative phosphate binding site [ion binding]; other site 195103008599 putative allosteric binding site; other site 195103008600 short chain dehydrogenase; Provisional; Region: PRK06701 195103008601 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 195103008602 NAD binding site [chemical binding]; other site 195103008603 metal binding site [ion binding]; metal-binding site 195103008604 active site 195103008605 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 195103008606 classical (c) SDRs; Region: SDR_c; cd05233 195103008607 NAD(P) binding site [chemical binding]; other site 195103008608 active site 195103008609 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 195103008610 Sulfate transporter family; Region: Sulfate_transp; pfam00916 195103008611 hybrid cluster protein; Provisional; Region: PRK05290 195103008612 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 195103008613 ACS interaction site; other site 195103008614 CODH interaction site; other site 195103008615 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 195103008616 hybrid metal cluster; other site 195103008617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 195103008618 Nucleoside recognition; Region: Gate; pfam07670 195103008619 Staygreen protein; Region: Staygreen; pfam12638 195103008620 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 195103008621 maltose O-acetyltransferase; Provisional; Region: PRK10092 195103008622 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 195103008623 active site 195103008624 substrate binding site [chemical binding]; other site 195103008625 trimer interface [polypeptide binding]; other site 195103008626 CoA binding site [chemical binding]; other site 195103008627 methionine sulfoxide reductase A; Provisional; Region: PRK14054 195103008628 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 195103008629 Predicted membrane protein [Function unknown]; Region: COG1511 195103008630 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 195103008631 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 195103008632 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 195103008633 Predicted membrane protein [Function unknown]; Region: COG1511 195103008634 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 195103008635 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 195103008636 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 195103008637 PhnA protein; Region: PhnA; pfam03831 195103008638 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 195103008639 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 195103008640 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 195103008641 TrkA-C domain; Region: TrkA_C; pfam02080 195103008642 Membrane protein of unknown function; Region: DUF360; pfam04020 195103008643 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 195103008644 E4 protein; Provisional; Region: PHA03419 195103008645 short chain dehydrogenase; Provisional; Region: PRK06701 195103008646 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 195103008647 NAD binding site [chemical binding]; other site 195103008648 metal binding site [ion binding]; metal-binding site 195103008649 active site 195103008650 Probable zinc-binding domain; Region: zf-trcl; pfam13451 195103008651 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 195103008652 TIGR03987 family protein; Region: TIGR03987 195103008653 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 195103008654 hypothetical protein; Provisional; Region: PRK05590 195103008655 Sporulation and spore germination; Region: Germane; pfam10646 195103008656 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 195103008657 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 195103008658 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 195103008659 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 195103008660 hinge; other site 195103008661 active site 195103008662 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 195103008663 dUTPase; Region: dUTPase_2; pfam08761 195103008664 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 195103008665 active site 195103008666 homodimer interface [polypeptide binding]; other site 195103008667 metal binding site [ion binding]; metal-binding site 195103008668 Protein of unknown function, DUF606; Region: DUF606; pfam04657 195103008669 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 195103008670 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 195103008671 active site 195103008672 catalytic residues [active] 195103008673 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 195103008674 Peptidase family M23; Region: Peptidase_M23; pfam01551 195103008675 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 195103008676 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 195103008677 DNA replication protein DnaC; Validated; Region: PRK06835 195103008678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103008679 Walker A motif; other site 195103008680 ATP binding site [chemical binding]; other site 195103008681 Walker B motif; other site 195103008682 flavoprotein, HI0933 family; Region: TIGR00275 195103008683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 195103008684 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 195103008685 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 195103008686 active site 195103008687 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 195103008688 active site 2 [active] 195103008689 active site 1 [active] 195103008690 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 195103008691 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 195103008692 active site 195103008693 Rubredoxin [Energy production and conversion]; Region: COG1773 195103008694 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 195103008695 iron binding site [ion binding]; other site 195103008696 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 195103008697 Rubrerythrin [Energy production and conversion]; Region: COG1592 195103008698 diiron binding motif [ion binding]; other site 195103008699 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 195103008700 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 195103008701 nudix motif; other site 195103008702 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 195103008703 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 195103008704 GDP-binding site [chemical binding]; other site 195103008705 ACT binding site; other site 195103008706 IMP binding site; other site 195103008707 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 195103008708 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 195103008709 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 195103008710 putative L-serine binding site [chemical binding]; other site 195103008711 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 195103008712 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 195103008713 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 195103008714 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 195103008715 dimer interface [polypeptide binding]; other site 195103008716 active site 195103008717 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 195103008718 putative active site [active] 195103008719 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 195103008720 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 195103008721 intersubunit interface [polypeptide binding]; other site 195103008722 active site 195103008723 zinc binding site [ion binding]; other site 195103008724 Na+ binding site [ion binding]; other site 195103008725 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 195103008726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 195103008727 DNA-binding site [nucleotide binding]; DNA binding site 195103008728 UTRA domain; Region: UTRA; pfam07702 195103008729 Preprotein translocase subunit; Region: YajC; cl00806 195103008730 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 195103008731 active pocket/dimerization site; other site 195103008732 active site 195103008733 phosphorylation site [posttranslational modification] 195103008734 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 195103008735 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 195103008736 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 195103008737 active site 195103008738 phosphorylation site [posttranslational modification] 195103008739 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 195103008740 pyrroline-5-carboxylate reductase; Region: PLN02688 195103008741 replicative DNA helicase; Provisional; Region: PRK05595 195103008742 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 195103008743 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 195103008744 Walker A motif; other site 195103008745 ATP binding site [chemical binding]; other site 195103008746 Walker B motif; other site 195103008747 DNA binding loops [nucleotide binding] 195103008748 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 195103008749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 195103008750 Walker A motif; other site 195103008751 ATP binding site [chemical binding]; other site 195103008752 Walker B motif; other site 195103008753 arginine finger; other site 195103008754 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 195103008755 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 195103008756 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 195103008757 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 195103008758 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 195103008759 DHH family; Region: DHH; pfam01368 195103008760 DHHA1 domain; Region: DHHA1; pfam02272 195103008761 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 195103008762 MazG-like family; Region: MazG-like; pfam12643 195103008763 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 195103008764 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 195103008765 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 195103008766 dimer interface [polypeptide binding]; other site 195103008767 ssDNA binding site [nucleotide binding]; other site 195103008768 tetramer (dimer of dimers) interface [polypeptide binding]; other site 195103008769 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 195103008770 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 195103008771 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 195103008772 Mechanosensitive ion channel; Region: MS_channel; pfam00924 195103008773 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 195103008774 LysE type translocator; Region: LysE; cl00565 195103008775 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 195103008776 cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977 195103008777 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 195103008778 catalytic residue [active] 195103008779 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 195103008780 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 195103008781 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 195103008782 ParB-like nuclease domain; Region: ParB; smart00470 195103008783 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 195103008784 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 195103008785 P-loop; other site 195103008786 Magnesium ion binding site [ion binding]; other site 195103008787 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 195103008788 Magnesium ion binding site [ion binding]; other site 195103008789 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 195103008790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 195103008791 S-adenosylmethionine binding site [chemical binding]; other site 195103008792 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 195103008793 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 195103008794 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 195103008795 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 195103008796 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 195103008797 trmE is a tRNA modification GTPase; Region: trmE; cd04164 195103008798 G1 box; other site 195103008799 GTP/Mg2+ binding site [chemical binding]; other site 195103008800 Switch I region; other site 195103008801 G2 box; other site 195103008802 Switch II region; other site 195103008803 G3 box; other site 195103008804 G4 box; other site 195103008805 G5 box; other site 195103008806 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 195103008807 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 195103008808 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 195103008809 G-X-X-G motif; other site 195103008810 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 195103008811 RxxxH motif; other site 195103008812 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 195103008813 Haemolytic domain; Region: Haemolytic; pfam01809 195103008814 ribonuclease P; Reviewed; Region: rnpA; PRK00499 195103008815 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399