-- dump date 20140619_045011 -- class Genbank::misc_feature -- table misc_feature_note -- id note 357809000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 357809000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 357809000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809000004 Walker A motif; other site 357809000005 ATP binding site [chemical binding]; other site 357809000006 Walker B motif; other site 357809000007 arginine finger; other site 357809000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 357809000009 DnaA box-binding interface [nucleotide binding]; other site 357809000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 357809000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 357809000012 putative DNA binding surface [nucleotide binding]; other site 357809000013 dimer interface [polypeptide binding]; other site 357809000014 beta-clamp/clamp loader binding surface; other site 357809000015 beta-clamp/translesion DNA polymerase binding surface; other site 357809000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809000017 RNA binding surface [nucleotide binding]; other site 357809000018 recombination protein F; Reviewed; Region: recF; PRK00064 357809000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 357809000020 Walker A/P-loop; other site 357809000021 ATP binding site [chemical binding]; other site 357809000022 Q-loop/lid; other site 357809000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809000024 ABC transporter signature motif; other site 357809000025 Walker B; other site 357809000026 D-loop; other site 357809000027 H-loop/switch region; other site 357809000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 357809000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809000030 Mg2+ binding site [ion binding]; other site 357809000031 G-X-G motif; other site 357809000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 357809000033 anchoring element; other site 357809000034 dimer interface [polypeptide binding]; other site 357809000035 ATP binding site [chemical binding]; other site 357809000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 357809000037 active site 357809000038 putative metal-binding site [ion binding]; other site 357809000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 357809000040 DNA gyrase subunit A; Validated; Region: PRK05560 357809000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 357809000042 CAP-like domain; other site 357809000043 active site 357809000044 primary dimer interface [polypeptide binding]; other site 357809000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357809000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357809000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357809000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357809000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357809000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357809000051 fumarate hydratase; Provisional; Region: PRK06246 357809000052 Fumarase C-terminus; Region: Fumerase_C; cl00795 357809000053 Rrf2 family protein; Region: rrf2_super; TIGR00738 357809000054 Transcriptional regulator; Region: Rrf2; pfam02082 357809000055 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 357809000056 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357809000057 homodimer interface [polypeptide binding]; other site 357809000058 substrate-cofactor binding pocket; other site 357809000059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809000060 catalytic residue [active] 357809000061 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 357809000062 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 357809000063 dimer interface [polypeptide binding]; other site 357809000064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809000065 catalytic residue [active] 357809000066 NAD-dependent deacetylase; Provisional; Region: PRK00481 357809000067 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 357809000068 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 357809000069 active site 357809000070 intersubunit interactions; other site 357809000071 catalytic residue [active] 357809000072 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 357809000073 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 357809000074 TPP-binding site [chemical binding]; other site 357809000075 dimer interface [polypeptide binding]; other site 357809000076 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 357809000077 PYR/PP interface [polypeptide binding]; other site 357809000078 dimer interface [polypeptide binding]; other site 357809000079 TPP binding site [chemical binding]; other site 357809000080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357809000081 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809000082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809000083 active site 357809000084 phosphorylation site [posttranslational modification] 357809000085 intermolecular recognition site; other site 357809000086 dimerization interface [polypeptide binding]; other site 357809000087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809000088 DNA binding site [nucleotide binding] 357809000089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809000090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357809000091 dimerization interface [polypeptide binding]; other site 357809000092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809000093 dimer interface [polypeptide binding]; other site 357809000094 phosphorylation site [posttranslational modification] 357809000095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809000096 ATP binding site [chemical binding]; other site 357809000097 Mg2+ binding site [ion binding]; other site 357809000098 G-X-G motif; other site 357809000099 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 357809000100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809000101 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 357809000102 Walker A/P-loop; other site 357809000103 ATP binding site [chemical binding]; other site 357809000104 Q-loop/lid; other site 357809000105 ABC transporter signature motif; other site 357809000106 Walker B; other site 357809000107 D-loop; other site 357809000108 H-loop/switch region; other site 357809000109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809000110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809000111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809000112 Walker A/P-loop; other site 357809000113 ATP binding site [chemical binding]; other site 357809000114 Q-loop/lid; other site 357809000115 ABC transporter signature motif; other site 357809000116 Walker B; other site 357809000117 D-loop; other site 357809000118 H-loop/switch region; other site 357809000119 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357809000120 synthetase active site [active] 357809000121 NTP binding site [chemical binding]; other site 357809000122 metal binding site [ion binding]; metal-binding site 357809000123 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 357809000124 RNA binding site [nucleotide binding]; other site 357809000125 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 357809000126 RNA binding site [nucleotide binding]; other site 357809000127 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 357809000128 RNA binding site [nucleotide binding]; other site 357809000129 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 357809000130 nudix motif; other site 357809000131 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 357809000132 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 357809000133 active site 357809000134 metal binding site [ion binding]; metal-binding site 357809000135 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 357809000136 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 357809000137 active site 357809000138 HIGH motif; other site 357809000139 KMSKS motif; other site 357809000140 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 357809000141 tRNA binding surface [nucleotide binding]; other site 357809000142 anticodon binding site; other site 357809000143 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 357809000144 dimer interface [polypeptide binding]; other site 357809000145 putative tRNA-binding site [nucleotide binding]; other site 357809000146 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 357809000147 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809000148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809000149 S-adenosylmethionine binding site [chemical binding]; other site 357809000150 AAA domain; Region: AAA_31; pfam13614 357809000151 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357809000152 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 357809000153 ATP binding site [chemical binding]; other site 357809000154 Walker A motif; other site 357809000155 hexamer interface [polypeptide binding]; other site 357809000156 Walker B motif; other site 357809000157 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 357809000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357809000159 phosphopeptide binding site; other site 357809000160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 357809000161 glycerol kinase; Provisional; Region: glpK; PRK00047 357809000162 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 357809000163 N- and C-terminal domain interface [polypeptide binding]; other site 357809000164 active site 357809000165 MgATP binding site [chemical binding]; other site 357809000166 catalytic site [active] 357809000167 metal binding site [ion binding]; metal-binding site 357809000168 glycerol binding site [chemical binding]; other site 357809000169 homotetramer interface [polypeptide binding]; other site 357809000170 homodimer interface [polypeptide binding]; other site 357809000171 FBP binding site [chemical binding]; other site 357809000172 protein IIAGlc interface [polypeptide binding]; other site 357809000173 Rhomboid family; Region: Rhomboid; pfam01694 357809000174 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 357809000175 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 357809000176 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 357809000177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809000178 Walker A motif; other site 357809000179 ATP binding site [chemical binding]; other site 357809000180 Walker B motif; other site 357809000181 arginine finger; other site 357809000182 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 357809000183 hypothetical protein; Validated; Region: PRK00153 357809000184 recombination protein RecR; Reviewed; Region: recR; PRK00076 357809000185 RecR protein; Region: RecR; pfam02132 357809000186 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 357809000187 putative active site [active] 357809000188 putative metal-binding site [ion binding]; other site 357809000189 tetramer interface [polypeptide binding]; other site 357809000190 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 357809000191 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 357809000192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809000193 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 357809000194 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 357809000195 active site 357809000196 intersubunit interface [polypeptide binding]; other site 357809000197 catalytic residue [active] 357809000198 YcxB-like protein; Region: YcxB; pfam14317 357809000199 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 357809000200 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357809000201 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357809000202 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 357809000203 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 357809000204 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 357809000205 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 357809000206 catalytic loop [active] 357809000207 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 357809000208 iron binding site [ion binding]; other site 357809000209 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 357809000210 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 357809000211 putative hydrolase; Validated; Region: PRK09248 357809000212 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 357809000213 active site 357809000214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809000215 sequence-specific DNA binding site [nucleotide binding]; other site 357809000216 salt bridge; other site 357809000217 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 357809000218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809000219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809000220 non-specific DNA binding site [nucleotide binding]; other site 357809000221 salt bridge; other site 357809000222 sequence-specific DNA binding site [nucleotide binding]; other site 357809000223 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 357809000224 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 357809000225 active site 357809000226 metal binding site [ion binding]; metal-binding site 357809000227 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809000228 Putative amidase domain; Region: Amidase_6; pfam12671 357809000229 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 357809000230 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 357809000231 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 357809000232 Predicted transcriptional regulators [Transcription]; Region: COG1725 357809000233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809000234 DNA-binding site [nucleotide binding]; DNA binding site 357809000235 Predicted membrane protein [General function prediction only]; Region: COG4194 357809000236 nodulation ABC transporter NodI; Provisional; Region: PRK13537 357809000237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809000238 Walker A/P-loop; other site 357809000239 ATP binding site [chemical binding]; other site 357809000240 Q-loop/lid; other site 357809000241 ABC transporter signature motif; other site 357809000242 Walker B; other site 357809000243 D-loop; other site 357809000244 H-loop/switch region; other site 357809000245 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809000246 ABC-2 type transporter; Region: ABC2_membrane; cl17235 357809000247 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357809000248 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357809000249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357809000250 Histidine kinase; Region: HisKA_3; pfam07730 357809000251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809000252 ATP binding site [chemical binding]; other site 357809000253 Mg2+ binding site [ion binding]; other site 357809000254 G-X-G motif; other site 357809000255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357809000256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809000257 active site 357809000258 phosphorylation site [posttranslational modification] 357809000259 intermolecular recognition site; other site 357809000260 dimerization interface [polypeptide binding]; other site 357809000261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357809000262 DNA binding residues [nucleotide binding] 357809000263 dimerization interface [polypeptide binding]; other site 357809000264 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 357809000265 Rubredoxin; Region: Rubredoxin; pfam00301 357809000266 iron binding site [ion binding]; other site 357809000267 Rubrerythrin [Energy production and conversion]; Region: COG1592 357809000268 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 357809000269 diiron binding motif [ion binding]; other site 357809000270 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 357809000271 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 357809000272 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 357809000273 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 357809000274 Rubredoxin; Region: Rubredoxin; pfam00301 357809000275 iron binding site [ion binding]; other site 357809000276 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 357809000277 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 357809000278 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357809000279 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 357809000280 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357809000281 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357809000282 catalytic loop [active] 357809000283 iron binding site [ion binding]; other site 357809000284 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 357809000285 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 357809000286 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809000287 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 357809000288 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 357809000289 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 357809000290 dimer interface [polypeptide binding]; other site 357809000291 [2Fe-2S] cluster binding site [ion binding]; other site 357809000292 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 357809000293 SLBB domain; Region: SLBB; pfam10531 357809000294 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 357809000295 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 357809000296 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 357809000297 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 357809000298 putative dimer interface [polypeptide binding]; other site 357809000299 [2Fe-2S] cluster binding site [ion binding]; other site 357809000300 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 357809000301 4Fe-4S binding domain; Region: Fer4; pfam00037 357809000302 4Fe-4S binding domain; Region: Fer4; pfam00037 357809000303 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 357809000304 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357809000305 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 357809000306 4Fe-4S binding domain; Region: Fer4; pfam00037 357809000307 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 357809000308 Putative Fe-S cluster; Region: FeS; cl17515 357809000309 PAS fold; Region: PAS; pfam00989 357809000310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357809000311 putative active site [active] 357809000312 heme pocket [chemical binding]; other site 357809000313 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 357809000314 dimer interface [polypeptide binding]; other site 357809000315 [2Fe-2S] cluster binding site [ion binding]; other site 357809000316 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809000317 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809000318 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 357809000319 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 357809000320 putative dimer interface [polypeptide binding]; other site 357809000321 putative anticodon binding site; other site 357809000322 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 357809000323 homodimer interface [polypeptide binding]; other site 357809000324 motif 1; other site 357809000325 motif 2; other site 357809000326 active site 357809000327 motif 3; other site 357809000328 QueT transporter; Region: QueT; pfam06177 357809000329 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809000330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809000331 non-specific DNA binding site [nucleotide binding]; other site 357809000332 salt bridge; other site 357809000333 sequence-specific DNA binding site [nucleotide binding]; other site 357809000334 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809000335 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 357809000336 DNA binding residues [nucleotide binding] 357809000337 dimer interface [polypeptide binding]; other site 357809000338 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 357809000339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809000340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809000341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809000342 Walker A/P-loop; other site 357809000343 ATP binding site [chemical binding]; other site 357809000344 Q-loop/lid; other site 357809000345 ABC transporter signature motif; other site 357809000346 Walker B; other site 357809000347 D-loop; other site 357809000348 H-loop/switch region; other site 357809000349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809000350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809000351 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809000352 Walker A/P-loop; other site 357809000353 ATP binding site [chemical binding]; other site 357809000354 Q-loop/lid; other site 357809000355 ABC transporter signature motif; other site 357809000356 Walker B; other site 357809000357 D-loop; other site 357809000358 H-loop/switch region; other site 357809000359 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357809000360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809000361 Zn2+ binding site [ion binding]; other site 357809000362 Mg2+ binding site [ion binding]; other site 357809000363 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 357809000364 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809000365 active site 357809000366 metal binding site [ion binding]; metal-binding site 357809000367 DNA binding site [nucleotide binding] 357809000368 AAA domain; Region: AAA_23; pfam13476 357809000369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809000370 Walker A/P-loop; other site 357809000371 ATP binding site [chemical binding]; other site 357809000372 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 357809000373 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 357809000374 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 357809000375 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809000376 active site 357809000377 DNA replication protein DnaC; Validated; Region: PRK06835 357809000378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809000379 Walker A motif; other site 357809000380 ATP binding site [chemical binding]; other site 357809000381 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 357809000382 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 357809000383 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 357809000384 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357809000385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357809000386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357809000387 regulatory protein SpoVG; Reviewed; Region: PRK13259 357809000388 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809000389 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 357809000390 NodB motif; other site 357809000391 active site 357809000392 catalytic site [active] 357809000393 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 357809000394 putative active site [active] 357809000395 catalytic residue [active] 357809000396 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 357809000397 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 357809000398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809000399 ATP binding site [chemical binding]; other site 357809000400 putative Mg++ binding site [ion binding]; other site 357809000401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809000402 nucleotide binding region [chemical binding]; other site 357809000403 ATP-binding site [chemical binding]; other site 357809000404 TRCF domain; Region: TRCF; pfam03461 357809000405 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 357809000406 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357809000407 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357809000408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809000409 Walker A/P-loop; other site 357809000410 ATP binding site [chemical binding]; other site 357809000411 Q-loop/lid; other site 357809000412 ABC transporter signature motif; other site 357809000413 Walker B; other site 357809000414 D-loop; other site 357809000415 H-loop/switch region; other site 357809000416 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 357809000417 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 357809000418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809000419 dimerization interface [polypeptide binding]; other site 357809000420 putative DNA binding site [nucleotide binding]; other site 357809000421 putative Zn2+ binding site [ion binding]; other site 357809000422 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 357809000423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809000424 DNA-binding site [nucleotide binding]; DNA binding site 357809000425 TrkA-C domain; Region: TrkA_C; pfam02080 357809000426 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 357809000427 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 357809000428 Walker A/P-loop; other site 357809000429 ATP binding site [chemical binding]; other site 357809000430 Q-loop/lid; other site 357809000431 ABC transporter signature motif; other site 357809000432 Walker B; other site 357809000433 D-loop; other site 357809000434 H-loop/switch region; other site 357809000435 FOG: CBS domain [General function prediction only]; Region: COG0517 357809000436 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 357809000437 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357809000438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809000439 dimer interface [polypeptide binding]; other site 357809000440 conserved gate region; other site 357809000441 putative PBP binding loops; other site 357809000442 ABC-ATPase subunit interface; other site 357809000443 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 357809000444 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 357809000445 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357809000446 metal-binding site [ion binding] 357809000447 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 357809000448 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809000449 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 357809000450 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 357809000451 putative active site [active] 357809000452 nucleotide binding site [chemical binding]; other site 357809000453 nudix motif; other site 357809000454 putative metal binding site [ion binding]; other site 357809000455 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 357809000456 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 357809000457 active site 357809000458 FMN binding site [chemical binding]; other site 357809000459 putative catalytic residues [active] 357809000460 substrate binding site [chemical binding]; other site 357809000461 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357809000462 Sulfatase; Region: Sulfatase; pfam00884 357809000463 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 357809000464 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 357809000465 dimerization interface 3.5A [polypeptide binding]; other site 357809000466 active site 357809000467 stage V sporulation protein T; Region: spore_V_T; TIGR02851 357809000468 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 357809000469 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 357809000470 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 357809000471 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 357809000472 DNA binding site [nucleotide binding] 357809000473 active site 357809000474 Patatin-like phospholipase of bacteria; Region: Pat17_PNPLA8_PNPLA9_like2; cd07215 357809000475 active site 357809000476 nucleophile elbow; other site 357809000477 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 357809000478 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 357809000479 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 357809000480 homodimer interface [polypeptide binding]; other site 357809000481 metal binding site [ion binding]; metal-binding site 357809000482 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 357809000483 IHF - DNA interface [nucleotide binding]; other site 357809000484 IHF dimer interface [polypeptide binding]; other site 357809000485 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809000486 RNA binding surface [nucleotide binding]; other site 357809000487 YabP family; Region: YabP; cl06766 357809000488 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 357809000489 Septum formation initiator; Region: DivIC; cl17659 357809000490 stage II sporulation protein E; Region: spore_II_E; TIGR02865 357809000491 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 357809000492 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 357809000493 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 357809000494 Ligand Binding Site [chemical binding]; other site 357809000495 TilS substrate C-terminal domain; Region: TilS_C; smart00977 357809000496 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809000497 active site 357809000498 FtsH Extracellular; Region: FtsH_ext; pfam06480 357809000499 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 357809000500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809000501 Walker A motif; other site 357809000502 ATP binding site [chemical binding]; other site 357809000503 Walker B motif; other site 357809000504 arginine finger; other site 357809000505 Peptidase family M41; Region: Peptidase_M41; pfam01434 357809000506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 357809000507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809000508 Coenzyme A binding pocket [chemical binding]; other site 357809000509 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 357809000510 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 357809000511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809000512 FeS/SAM binding site; other site 357809000513 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 357809000514 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 357809000515 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357809000516 minor groove reading motif; other site 357809000517 helix-hairpin-helix signature motif; other site 357809000518 substrate binding pocket [chemical binding]; other site 357809000519 active site 357809000520 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 357809000521 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 357809000522 active site 357809000523 catalytic site [active] 357809000524 substrate binding site [chemical binding]; other site 357809000525 VanW like protein; Region: VanW; pfam04294 357809000526 G5 domain; Region: G5; pfam07501 357809000527 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 357809000528 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 357809000529 dimerization interface [polypeptide binding]; other site 357809000530 putative ATP binding site [chemical binding]; other site 357809000531 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 357809000532 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 357809000533 AsnC family; Region: AsnC_trans_reg; pfam01037 357809000534 hypothetical protein; Validated; Region: PRK07682 357809000535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809000536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809000537 homodimer interface [polypeptide binding]; other site 357809000538 catalytic residue [active] 357809000539 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 357809000540 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 357809000541 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 357809000542 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 357809000543 MutS domain III; Region: MutS_III; pfam05192 357809000544 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 357809000545 Walker A/P-loop; other site 357809000546 ATP binding site [chemical binding]; other site 357809000547 Q-loop/lid; other site 357809000548 ABC transporter signature motif; other site 357809000549 Walker B; other site 357809000550 D-loop; other site 357809000551 H-loop/switch region; other site 357809000552 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 357809000553 Smr domain; Region: Smr; pfam01713 357809000554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809000556 active site 357809000557 phosphorylation site [posttranslational modification] 357809000558 intermolecular recognition site; other site 357809000559 dimerization interface [polypeptide binding]; other site 357809000560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809000561 DNA binding site [nucleotide binding] 357809000562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809000563 dimerization interface [polypeptide binding]; other site 357809000564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809000565 dimer interface [polypeptide binding]; other site 357809000566 phosphorylation site [posttranslational modification] 357809000567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809000568 ATP binding site [chemical binding]; other site 357809000569 Mg2+ binding site [ion binding]; other site 357809000570 G-X-G motif; other site 357809000571 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357809000572 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357809000573 protein binding site [polypeptide binding]; other site 357809000574 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357809000575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809000576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357809000577 Coenzyme A binding pocket [chemical binding]; other site 357809000578 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 357809000579 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 357809000580 generic binding surface I; other site 357809000581 generic binding surface II; other site 357809000582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809000583 Zn2+ binding site [ion binding]; other site 357809000584 Mg2+ binding site [ion binding]; other site 357809000585 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 357809000586 TRAM domain; Region: TRAM; cl01282 357809000587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809000588 S-adenosylmethionine binding site [chemical binding]; other site 357809000589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809000590 Zn2+ binding site [ion binding]; other site 357809000591 Mg2+ binding site [ion binding]; other site 357809000592 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 357809000593 Predicted acetyltransferase [General function prediction only]; Region: COG2388 357809000594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809000595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809000596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809000597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809000598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 357809000599 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357809000600 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809000601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809000602 non-specific DNA binding site [nucleotide binding]; other site 357809000603 salt bridge; other site 357809000604 sequence-specific DNA binding site [nucleotide binding]; other site 357809000605 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 357809000606 MPN+ (JAMM) motif; other site 357809000607 Zinc-binding site [ion binding]; other site 357809000608 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809000609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809000610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809000611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809000612 metal binding site [ion binding]; metal-binding site 357809000613 active site 357809000614 I-site; other site 357809000615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809000616 non-specific DNA binding site [nucleotide binding]; other site 357809000617 salt bridge; other site 357809000618 sequence-specific DNA binding site [nucleotide binding]; other site 357809000619 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809000620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809000621 metal binding site [ion binding]; metal-binding site 357809000622 active site 357809000623 I-site; other site 357809000624 myosin-cross-reactive antigen; Provisional; Region: PRK13977 357809000625 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 357809000626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809000627 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 357809000628 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809000629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809000630 S-adenosylmethionine binding site [chemical binding]; other site 357809000631 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809000632 dimerization interface [polypeptide binding]; other site 357809000633 putative DNA binding site [nucleotide binding]; other site 357809000634 putative Zn2+ binding site [ion binding]; other site 357809000635 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 357809000636 SdpI/YhfL protein family; Region: SdpI; pfam13630 357809000637 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 357809000638 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 357809000639 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809000640 catalytic residue [active] 357809000641 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 357809000642 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 357809000643 Ligand Binding Site [chemical binding]; other site 357809000644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809000645 Radical SAM superfamily; Region: Radical_SAM; pfam04055 357809000646 FeS/SAM binding site; other site 357809000647 Predicted transcriptional regulators [Transcription]; Region: COG1725 357809000648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809000649 DNA-binding site [nucleotide binding]; DNA binding site 357809000650 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809000651 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809000652 Walker A/P-loop; other site 357809000653 ATP binding site [chemical binding]; other site 357809000654 Q-loop/lid; other site 357809000655 ABC transporter signature motif; other site 357809000656 Walker B; other site 357809000657 D-loop; other site 357809000658 H-loop/switch region; other site 357809000659 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 357809000660 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 357809000661 active site 357809000662 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 357809000663 catalytic motif [active] 357809000664 Zn binding site [ion binding]; other site 357809000665 Beta-lactamase; Region: Beta-lactamase; pfam00144 357809000666 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357809000667 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 357809000668 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 357809000669 inhibitor binding site; inhibition site 357809000670 active site 357809000671 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809000672 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809000673 Walker A/P-loop; other site 357809000674 ATP binding site [chemical binding]; other site 357809000675 Q-loop/lid; other site 357809000676 ABC transporter signature motif; other site 357809000677 Walker B; other site 357809000678 D-loop; other site 357809000679 H-loop/switch region; other site 357809000680 FtsX-like permease family; Region: FtsX; pfam02687 357809000681 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809000682 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809000683 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809000684 Walker A/P-loop; other site 357809000685 ATP binding site [chemical binding]; other site 357809000686 Q-loop/lid; other site 357809000687 ABC transporter signature motif; other site 357809000688 Walker B; other site 357809000689 D-loop; other site 357809000690 H-loop/switch region; other site 357809000691 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809000692 FtsX-like permease family; Region: FtsX; pfam02687 357809000693 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357809000694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809000695 dimerization interface [polypeptide binding]; other site 357809000696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809000697 dimer interface [polypeptide binding]; other site 357809000698 phosphorylation site [posttranslational modification] 357809000699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809000700 ATP binding site [chemical binding]; other site 357809000701 Mg2+ binding site [ion binding]; other site 357809000702 G-X-G motif; other site 357809000703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809000704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809000705 active site 357809000706 phosphorylation site [posttranslational modification] 357809000707 intermolecular recognition site; other site 357809000708 dimerization interface [polypeptide binding]; other site 357809000709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809000710 DNA binding site [nucleotide binding] 357809000711 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 357809000712 4Fe-4S binding domain; Region: Fer4_5; pfam12801 357809000713 4Fe-4S binding domain; Region: Fer4_5; pfam12801 357809000714 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 357809000715 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357809000716 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357809000717 catalytic residues [active] 357809000718 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 357809000719 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 357809000720 hexamer (dimer of trimers) interface [polypeptide binding]; other site 357809000721 substrate binding site [chemical binding]; other site 357809000722 trimer interface [polypeptide binding]; other site 357809000723 Mn binding site [ion binding]; other site 357809000724 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357809000725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809000726 dimerization interface [polypeptide binding]; other site 357809000727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809000728 dimer interface [polypeptide binding]; other site 357809000729 putative CheW interface [polypeptide binding]; other site 357809000730 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 357809000731 MgtC family; Region: MgtC; pfam02308 357809000732 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 357809000733 trigger factor; Region: tig; TIGR00115 357809000734 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357809000735 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 357809000736 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 357809000737 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 357809000738 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 357809000739 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 357809000740 ArsC family; Region: ArsC; pfam03960 357809000741 putative ArsC-like catalytic residues; other site 357809000742 putative TRX-like catalytic residues [active] 357809000743 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 357809000744 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357809000745 HSP70 interaction site [polypeptide binding]; other site 357809000746 Stage III sporulation protein D; Region: SpoIIID; pfam12116 357809000747 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 357809000748 SLBB domain; Region: SLBB; pfam10531 357809000749 4Fe-4S binding domain; Region: Fer4; cl02805 357809000750 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 357809000751 FMN-binding domain; Region: FMN_bind; cl01081 357809000752 electron transport complex RsxE subunit; Provisional; Region: PRK12405 357809000753 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 357809000754 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357809000755 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 357809000756 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357809000757 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357809000758 putative alpha-glucosidase; Provisional; Region: PRK10658 357809000759 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 357809000760 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 357809000761 active site 357809000762 homotrimer interface [polypeptide binding]; other site 357809000763 catalytic site [active] 357809000764 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 357809000765 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 357809000766 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357809000767 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357809000768 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 357809000769 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357809000770 active site 357809000771 HIGH motif; other site 357809000772 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357809000773 active site 357809000774 KMSKS motif; other site 357809000775 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 357809000776 Part of AAA domain; Region: AAA_19; pfam13245 357809000777 Family description; Region: UvrD_C_2; pfam13538 357809000778 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 357809000779 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 357809000780 DEAD_2; Region: DEAD_2; pfam06733 357809000781 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 357809000782 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 357809000783 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 357809000784 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 357809000785 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357809000786 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357809000787 substrate binding site [chemical binding]; other site 357809000788 ATP binding site [chemical binding]; other site 357809000789 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 357809000790 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 357809000791 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809000792 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809000793 DNA binding residues [nucleotide binding] 357809000794 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 357809000795 DHHW protein; Region: DHHW; pfam14286 357809000796 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357809000797 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357809000798 putative acyl-acceptor binding pocket; other site 357809000799 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 357809000800 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357809000801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809000802 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357809000803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809000804 DNA binding residues [nucleotide binding] 357809000805 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 357809000806 S17 interaction site [polypeptide binding]; other site 357809000807 S8 interaction site; other site 357809000808 16S rRNA interaction site [nucleotide binding]; other site 357809000809 streptomycin interaction site [chemical binding]; other site 357809000810 23S rRNA interaction site [nucleotide binding]; other site 357809000811 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 357809000812 30S ribosomal protein S7; Validated; Region: PRK05302 357809000813 elongation factor G; Reviewed; Region: PRK00007 357809000814 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 357809000815 G1 box; other site 357809000816 putative GEF interaction site [polypeptide binding]; other site 357809000817 GTP/Mg2+ binding site [chemical binding]; other site 357809000818 Switch I region; other site 357809000819 G2 box; other site 357809000820 G3 box; other site 357809000821 Switch II region; other site 357809000822 G4 box; other site 357809000823 G5 box; other site 357809000824 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357809000825 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 357809000826 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 357809000827 elongation factor Tu; Reviewed; Region: PRK00049 357809000828 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 357809000829 G1 box; other site 357809000830 GEF interaction site [polypeptide binding]; other site 357809000831 GTP/Mg2+ binding site [chemical binding]; other site 357809000832 Switch I region; other site 357809000833 G2 box; other site 357809000834 G3 box; other site 357809000835 Switch II region; other site 357809000836 G4 box; other site 357809000837 G5 box; other site 357809000838 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 357809000839 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 357809000840 Antibiotic Binding Site [chemical binding]; other site 357809000841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809000842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809000843 active site 357809000844 I-site; other site 357809000845 metal binding site [ion binding]; metal-binding site 357809000846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357809000847 rod shape-determining protein Mbl; Provisional; Region: PRK13928 357809000848 MreB and similar proteins; Region: MreB_like; cd10225 357809000849 nucleotide binding site [chemical binding]; other site 357809000850 Mg binding site [ion binding]; other site 357809000851 putative protofilament interaction site [polypeptide binding]; other site 357809000852 RodZ interaction site [polypeptide binding]; other site 357809000853 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 357809000854 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357809000855 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 357809000856 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 357809000857 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357809000858 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357809000859 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 357809000860 AAA domain; Region: AAA_30; pfam13604 357809000861 Family description; Region: UvrD_C_2; pfam13538 357809000862 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809000863 active site 357809000864 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 357809000865 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809000866 active site 357809000867 flagellar operon protein TIGR03826; Region: YvyF 357809000868 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 357809000869 S1 domain; Region: S1_2; pfam13509 357809000870 S1 domain; Region: S1_2; pfam13509 357809000871 S1 RNA binding domain; Region: S1; pfam00575 357809000872 RNA binding site [nucleotide binding]; other site 357809000873 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 357809000874 active site 357809000875 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 357809000876 active site 2 [active] 357809000877 active site 1 [active] 357809000878 CAAX protease self-immunity; Region: Abi; pfam02517 357809000879 Putative motility protein; Region: YjfB_motility; pfam14070 357809000880 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 357809000881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809000882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809000883 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 357809000884 30S subunit binding site; other site 357809000885 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 357809000886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357809000887 ATP binding site [chemical binding]; other site 357809000888 putative Mg++ binding site [ion binding]; other site 357809000889 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 357809000890 SEC-C motif; Region: SEC-C; pfam02810 357809000891 peptide chain release factor 2; Provisional; Region: PRK05589 357809000892 This domain is found in peptide chain release factors; Region: PCRF; smart00937 357809000893 RF-1 domain; Region: RF-1; pfam00472 357809000894 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 357809000895 excinuclease ABC subunit B; Provisional; Region: PRK05298 357809000896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809000897 ATP binding site [chemical binding]; other site 357809000898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809000899 nucleotide binding region [chemical binding]; other site 357809000900 ATP-binding site [chemical binding]; other site 357809000901 Ultra-violet resistance protein B; Region: UvrB; pfam12344 357809000902 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 357809000903 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357809000904 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357809000905 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 357809000906 5'-nucleotidase; Provisional; Region: PRK03826 357809000907 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 357809000908 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809000909 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357809000910 von Willebrand factor; Region: vWF_A; pfam12450 357809000911 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 357809000912 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 357809000913 metal ion-dependent adhesion site (MIDAS); other site 357809000914 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 357809000915 GMP synthase; Reviewed; Region: guaA; PRK00074 357809000916 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 357809000917 AMP/PPi binding site [chemical binding]; other site 357809000918 candidate oxyanion hole; other site 357809000919 catalytic triad [active] 357809000920 potential glutamine specificity residues [chemical binding]; other site 357809000921 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 357809000922 ATP Binding subdomain [chemical binding]; other site 357809000923 Ligand Binding sites [chemical binding]; other site 357809000924 Dimerization subdomain; other site 357809000925 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 357809000926 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 357809000927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809000928 S-adenosylmethionine binding site [chemical binding]; other site 357809000929 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 357809000930 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 357809000931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809000932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809000933 ATP binding site [chemical binding]; other site 357809000934 Mg2+ binding site [ion binding]; other site 357809000935 G-X-G motif; other site 357809000936 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 357809000937 active site 357809000938 Helix-turn-helix domain; Region: HTH_17; pfam12728 357809000939 Fic family protein [Function unknown]; Region: COG3177 357809000940 Fic/DOC family; Region: Fic; pfam02661 357809000941 MraW methylase family; Region: Methyltransf_5; cl17771 357809000942 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 357809000943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809000944 salt bridge; other site 357809000945 non-specific DNA binding site [nucleotide binding]; other site 357809000946 sequence-specific DNA binding site [nucleotide binding]; other site 357809000947 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 357809000948 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357809000949 DNA binding residues [nucleotide binding] 357809000950 dimer interface [polypeptide binding]; other site 357809000951 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 357809000952 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 357809000953 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 357809000954 active site 357809000955 PHP-associated; Region: PHP_C; pfam13263 357809000956 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 357809000957 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 357809000958 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357809000959 Double zinc ribbon; Region: DZR; pfam12773 357809000960 trigger factor; Region: tig; TIGR00115 357809000961 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357809000962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809000963 dimerization interface [polypeptide binding]; other site 357809000964 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809000965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809000966 dimer interface [polypeptide binding]; other site 357809000967 putative CheW interface [polypeptide binding]; other site 357809000968 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 357809000969 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 357809000970 DNA binding site [nucleotide binding] 357809000971 active site 357809000972 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 357809000973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809000974 Coenzyme A binding pocket [chemical binding]; other site 357809000975 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 357809000976 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809000977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809000978 dimer interface [polypeptide binding]; other site 357809000979 conserved gate region; other site 357809000980 putative PBP binding loops; other site 357809000981 ABC-ATPase subunit interface; other site 357809000982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809000983 dimer interface [polypeptide binding]; other site 357809000984 conserved gate region; other site 357809000985 putative PBP binding loops; other site 357809000986 ABC-ATPase subunit interface; other site 357809000987 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809000988 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809000989 Histidine kinase; Region: His_kinase; pfam06580 357809000990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809000991 ATP binding site [chemical binding]; other site 357809000992 Mg2+ binding site [ion binding]; other site 357809000993 G-X-G motif; other site 357809000994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809000995 active site 357809000996 phosphorylation site [posttranslational modification] 357809000997 intermolecular recognition site; other site 357809000998 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809000999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001000 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 357809001001 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 357809001002 CAP-like domain; other site 357809001003 active site 357809001004 primary dimer interface [polypeptide binding]; other site 357809001005 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357809001006 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 357809001007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809001008 ATP binding site [chemical binding]; other site 357809001009 Mg2+ binding site [ion binding]; other site 357809001010 G-X-G motif; other site 357809001011 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 357809001012 anchoring element; other site 357809001013 dimer interface [polypeptide binding]; other site 357809001014 ATP binding site [chemical binding]; other site 357809001015 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 357809001016 active site 357809001017 putative metal-binding site [ion binding]; other site 357809001018 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 357809001019 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357809001020 active site 357809001021 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 357809001022 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 357809001023 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 357809001024 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 357809001025 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 357809001026 Ligand binding site; other site 357809001027 Putative Catalytic site; other site 357809001028 DXD motif; other site 357809001029 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357809001030 active site 357809001031 nucleotide binding site [chemical binding]; other site 357809001032 HIGH motif; other site 357809001033 KMSKS motif; other site 357809001034 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 357809001035 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 357809001036 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 357809001037 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 357809001038 active site 357809001039 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357809001040 substrate binding site [chemical binding]; other site 357809001041 catalytic residues [active] 357809001042 dimer interface [polypeptide binding]; other site 357809001043 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 357809001044 FlgN protein; Region: FlgN; pfam05130 357809001045 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 357809001046 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357809001047 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 357809001048 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 357809001049 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357809001050 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 357809001051 FliW protein; Region: FliW; cl00740 357809001052 carbon storage regulator; Provisional; Region: PRK01712 357809001053 FlaG protein; Region: FlaG; pfam03646 357809001054 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 357809001055 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 357809001056 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 357809001057 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 357809001058 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 357809001059 flagellin; Provisional; Region: PRK12804 357809001060 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 357809001061 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 357809001062 amidophosphoribosyltransferase; Provisional; Region: PRK05793 357809001063 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 357809001064 active site 357809001065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809001066 active site 357809001067 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 357809001068 Predicted dehydrogenase [General function prediction only]; Region: COG0579 357809001069 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357809001070 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357809001071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357809001072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809001073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809001074 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357809001075 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 357809001076 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809001077 active site 357809001078 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 357809001079 CTP synthetase; Validated; Region: pyrG; PRK05380 357809001080 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 357809001081 Catalytic site [active] 357809001082 active site 357809001083 UTP binding site [chemical binding]; other site 357809001084 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 357809001085 active site 357809001086 putative oxyanion hole; other site 357809001087 catalytic triad [active] 357809001088 FtsH Extracellular; Region: FtsH_ext; pfam06480 357809001089 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 357809001090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809001091 Walker A motif; other site 357809001092 ATP binding site [chemical binding]; other site 357809001093 Walker B motif; other site 357809001094 arginine finger; other site 357809001095 Peptidase family M41; Region: Peptidase_M41; pfam01434 357809001096 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 357809001097 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 357809001098 GIY-YIG motif/motif A; other site 357809001099 active site 357809001100 catalytic site [active] 357809001101 putative DNA binding site [nucleotide binding]; other site 357809001102 metal binding site [ion binding]; metal-binding site 357809001103 UvrB/uvrC motif; Region: UVR; pfam02151 357809001104 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 357809001105 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 357809001106 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 357809001107 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 357809001108 Hpr binding site; other site 357809001109 active site 357809001110 homohexamer subunit interaction site [polypeptide binding]; other site 357809001111 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 357809001112 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357809001113 nucleotide binding site [chemical binding]; other site 357809001114 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 357809001115 FAD binding domain; Region: FAD_binding_4; pfam01565 357809001116 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 357809001117 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 357809001118 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 357809001119 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 357809001120 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357809001121 dimerization domain swap beta strand [polypeptide binding]; other site 357809001122 regulatory protein interface [polypeptide binding]; other site 357809001123 active site 357809001124 regulatory phosphorylation site [posttranslational modification]; other site 357809001125 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357809001126 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357809001127 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 357809001128 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 357809001129 active site 357809001130 PHP Thumb interface [polypeptide binding]; other site 357809001131 metal binding site [ion binding]; metal-binding site 357809001132 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 357809001133 generic binding surface II; other site 357809001134 generic binding surface I; other site 357809001135 6-phosphofructokinase; Provisional; Region: PRK03202 357809001136 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 357809001137 active site 357809001138 ADP/pyrophosphate binding site [chemical binding]; other site 357809001139 dimerization interface [polypeptide binding]; other site 357809001140 allosteric effector site; other site 357809001141 fructose-1,6-bisphosphate binding site; other site 357809001142 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809001143 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809001144 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 357809001145 Walker A/P-loop; other site 357809001146 ATP binding site [chemical binding]; other site 357809001147 Q-loop/lid; other site 357809001148 ABC transporter signature motif; other site 357809001149 Walker B; other site 357809001150 D-loop; other site 357809001151 H-loop/switch region; other site 357809001152 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 357809001153 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 357809001154 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 357809001155 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 357809001156 RNA binding site [nucleotide binding]; other site 357809001157 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809001158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001159 dimer interface [polypeptide binding]; other site 357809001160 conserved gate region; other site 357809001161 ABC-ATPase subunit interface; other site 357809001162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809001163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001164 dimer interface [polypeptide binding]; other site 357809001165 conserved gate region; other site 357809001166 putative PBP binding loops; other site 357809001167 ABC-ATPase subunit interface; other site 357809001168 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809001169 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809001170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001171 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 357809001172 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 357809001173 metal binding site [ion binding]; metal-binding site 357809001174 active site 357809001175 Predicted membrane protein [Function unknown]; Region: COG3601 357809001176 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 357809001177 YcxB-like protein; Region: YcxB; pfam14317 357809001178 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 357809001179 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 357809001180 Glycoprotease family; Region: Peptidase_M22; pfam00814 357809001181 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 357809001182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809001183 Coenzyme A binding pocket [chemical binding]; other site 357809001184 ribonuclease Z; Reviewed; Region: PRK00055 357809001185 UGMP family protein; Validated; Region: PRK09604 357809001186 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 357809001187 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 357809001188 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 357809001189 substrate binding site; other site 357809001190 dimer interface; other site 357809001191 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 357809001192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809001193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809001194 active site 357809001195 phosphorylation site [posttranslational modification] 357809001196 intermolecular recognition site; other site 357809001197 dimerization interface [polypeptide binding]; other site 357809001198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809001199 DNA binding site [nucleotide binding] 357809001200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809001201 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809001202 Walker A/P-loop; other site 357809001203 ATP binding site [chemical binding]; other site 357809001204 Q-loop/lid; other site 357809001205 ABC transporter signature motif; other site 357809001206 Walker B; other site 357809001207 D-loop; other site 357809001208 H-loop/switch region; other site 357809001209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809001210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809001211 dimer interface [polypeptide binding]; other site 357809001212 phosphorylation site [posttranslational modification] 357809001213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809001214 ATP binding site [chemical binding]; other site 357809001215 Mg2+ binding site [ion binding]; other site 357809001216 G-X-G motif; other site 357809001217 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809001218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809001219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809001220 ABC transporter; Region: ABC_tran_2; pfam12848 357809001221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809001222 Predicted membrane protein [Function unknown]; Region: COG4709 357809001223 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 357809001224 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357809001225 active site residue [active] 357809001226 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 357809001227 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 357809001228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357809001229 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357809001230 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357809001231 PGAP1-like protein; Region: PGAP1; pfam07819 357809001232 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 357809001233 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 357809001234 active site 357809001235 metal binding site [ion binding]; metal-binding site 357809001236 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 357809001237 active site 357809001238 dimerization interface [polypeptide binding]; other site 357809001239 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 357809001240 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809001241 active site 357809001242 metal binding site [ion binding]; metal-binding site 357809001243 homotetramer interface [polypeptide binding]; other site 357809001244 DJ-1 family protein; Region: not_thiJ; TIGR01383 357809001245 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 357809001246 conserved cys residue [active] 357809001247 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 357809001248 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 357809001249 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 357809001250 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 357809001251 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 357809001252 active site 357809001253 substrate binding site [chemical binding]; other site 357809001254 metal binding site [ion binding]; metal-binding site 357809001255 trigger factor; Provisional; Region: tig; PRK01490 357809001256 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357809001257 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 357809001258 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 357809001259 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 357809001260 oligomer interface [polypeptide binding]; other site 357809001261 active site residues [active] 357809001262 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 357809001263 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 357809001264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809001265 Walker A motif; other site 357809001266 ATP binding site [chemical binding]; other site 357809001267 Walker B motif; other site 357809001268 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357809001269 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 357809001270 Found in ATP-dependent protease La (LON); Region: LON; smart00464 357809001271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809001272 Walker A motif; other site 357809001273 ATP binding site [chemical binding]; other site 357809001274 Walker B motif; other site 357809001275 arginine finger; other site 357809001276 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 357809001277 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 357809001278 G1 box; other site 357809001279 GTP/Mg2+ binding site [chemical binding]; other site 357809001280 Switch I region; other site 357809001281 G2 box; other site 357809001282 G3 box; other site 357809001283 Switch II region; other site 357809001284 G4 box; other site 357809001285 G5 box; other site 357809001286 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809001287 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809001288 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809001289 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809001290 dimer interface [polypeptide binding]; other site 357809001291 putative CheW interface [polypeptide binding]; other site 357809001292 Predicted membrane protein [Function unknown]; Region: COG4129 357809001293 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 357809001294 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 357809001295 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357809001296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001297 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809001298 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809001299 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 357809001300 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 357809001301 metal binding site [ion binding]; metal-binding site 357809001302 Class I aldolases; Region: Aldolase_Class_I; cl17187 357809001303 catalytic residue [active] 357809001304 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357809001305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357809001306 active site 357809001307 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001309 dimer interface [polypeptide binding]; other site 357809001310 conserved gate region; other site 357809001311 ABC-ATPase subunit interface; other site 357809001312 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809001313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001314 dimer interface [polypeptide binding]; other site 357809001315 conserved gate region; other site 357809001316 putative PBP binding loops; other site 357809001317 ABC-ATPase subunit interface; other site 357809001318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809001319 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 357809001320 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 357809001321 putative ligand binding site [chemical binding]; other site 357809001322 putative NAD binding site [chemical binding]; other site 357809001323 catalytic site [active] 357809001324 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809001325 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809001326 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357809001327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809001328 Coenzyme A binding pocket [chemical binding]; other site 357809001329 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 357809001330 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 357809001331 Ferredoxin [Energy production and conversion]; Region: COG1146 357809001332 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 357809001333 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 357809001334 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809001335 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357809001336 NodB motif; other site 357809001337 active site 357809001338 catalytic site [active] 357809001339 metal binding site [ion binding]; metal-binding site 357809001340 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 357809001341 nucleotide binding site/active site [active] 357809001342 HIT family signature motif; other site 357809001343 catalytic residue [active] 357809001344 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 357809001345 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 357809001346 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 357809001347 Malic enzyme, N-terminal domain; Region: malic; pfam00390 357809001348 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 357809001349 putative NAD(P) binding site [chemical binding]; other site 357809001350 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 357809001351 Transcription termination factor [Transcription]; Region: Rho; COG1158 357809001352 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 357809001353 RNA binding site [nucleotide binding]; other site 357809001354 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357809001355 Walker A motif; other site 357809001356 ATP binding site [chemical binding]; other site 357809001357 Walker B motif; other site 357809001358 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 357809001359 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 357809001360 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 357809001361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809001362 S-adenosylmethionine binding site [chemical binding]; other site 357809001363 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 357809001364 peptide chain release factor 1; Validated; Region: prfA; PRK00591 357809001365 This domain is found in peptide chain release factors; Region: PCRF; smart00937 357809001366 RF-1 domain; Region: RF-1; pfam00472 357809001367 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 357809001368 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 357809001369 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357809001370 TrkA-N domain; Region: TrkA_N; pfam02254 357809001371 TrkA-C domain; Region: TrkA_C; pfam02080 357809001372 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 357809001373 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 357809001374 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357809001375 phosphodiesterase; Provisional; Region: PRK12704 357809001376 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 357809001377 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 357809001378 active site 357809001379 dimer interface [polypeptide binding]; other site 357809001380 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 357809001381 dimer interface [polypeptide binding]; other site 357809001382 active site 357809001383 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357809001384 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 357809001385 active site 357809001386 nucleophile elbow; other site 357809001387 ornithine carbamoyltransferase; Validated; Region: PRK02102 357809001388 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357809001389 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357809001390 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 357809001391 pantothenate kinase; Reviewed; Region: PRK13318 357809001392 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 357809001393 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 357809001394 FMN binding site [chemical binding]; other site 357809001395 active site 357809001396 catalytic residues [active] 357809001397 substrate binding site [chemical binding]; other site 357809001398 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 357809001399 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357809001400 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 357809001401 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 357809001402 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 357809001403 catalytic domain interface [polypeptide binding]; other site 357809001404 homodimer interface [polypeptide binding]; other site 357809001405 putative active site [active] 357809001406 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357809001407 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 357809001408 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357809001409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001410 dimer interface [polypeptide binding]; other site 357809001411 conserved gate region; other site 357809001412 putative PBP binding loops; other site 357809001413 ABC-ATPase subunit interface; other site 357809001414 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 357809001415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001416 dimer interface [polypeptide binding]; other site 357809001417 conserved gate region; other site 357809001418 putative PBP binding loops; other site 357809001419 ABC-ATPase subunit interface; other site 357809001420 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 357809001421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809001422 Walker A/P-loop; other site 357809001423 ATP binding site [chemical binding]; other site 357809001424 Q-loop/lid; other site 357809001425 ABC transporter signature motif; other site 357809001426 Walker B; other site 357809001427 D-loop; other site 357809001428 H-loop/switch region; other site 357809001429 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357809001430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809001431 Walker A/P-loop; other site 357809001432 ATP binding site [chemical binding]; other site 357809001433 Q-loop/lid; other site 357809001434 ABC transporter signature motif; other site 357809001435 Walker B; other site 357809001436 D-loop; other site 357809001437 H-loop/switch region; other site 357809001438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357809001439 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357809001440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809001441 dimerization interface [polypeptide binding]; other site 357809001442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809001443 dimer interface [polypeptide binding]; other site 357809001444 putative CheW interface [polypeptide binding]; other site 357809001445 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 357809001446 metal binding site 2 [ion binding]; metal-binding site 357809001447 putative DNA binding helix; other site 357809001448 metal binding site 1 [ion binding]; metal-binding site 357809001449 dimer interface [polypeptide binding]; other site 357809001450 structural Zn2+ binding site [ion binding]; other site 357809001451 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357809001452 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 357809001453 intersubunit interface [polypeptide binding]; other site 357809001454 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 357809001455 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 357809001456 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 357809001457 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 357809001458 ABC-ATPase subunit interface; other site 357809001459 dimer interface [polypeptide binding]; other site 357809001460 putative PBP binding regions; other site 357809001461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809001462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809001463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809001464 Walker A/P-loop; other site 357809001465 ATP binding site [chemical binding]; other site 357809001466 Q-loop/lid; other site 357809001467 ABC transporter signature motif; other site 357809001468 Walker B; other site 357809001469 D-loop; other site 357809001470 H-loop/switch region; other site 357809001471 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809001472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809001473 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809001474 Walker A/P-loop; other site 357809001475 ATP binding site [chemical binding]; other site 357809001476 Q-loop/lid; other site 357809001477 ABC transporter signature motif; other site 357809001478 Walker B; other site 357809001479 D-loop; other site 357809001480 H-loop/switch region; other site 357809001481 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 357809001482 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357809001483 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 357809001484 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 357809001485 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 357809001486 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 357809001487 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 357809001488 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 357809001489 23S rRNA binding site [nucleotide binding]; other site 357809001490 L21 binding site [polypeptide binding]; other site 357809001491 L13 binding site [polypeptide binding]; other site 357809001492 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809001493 cytoskeletal protein RodZ; Provisional; Region: PRK10856 357809001494 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 357809001495 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 357809001496 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357809001497 H+ Antiporter protein; Region: 2A0121; TIGR00900 357809001498 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 357809001499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809001500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809001501 homodimer interface [polypeptide binding]; other site 357809001502 catalytic residue [active] 357809001503 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 357809001504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809001505 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 357809001506 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357809001507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357809001508 NAD(P) binding site [chemical binding]; other site 357809001509 active site 357809001510 peroxiredoxin; Provisional; Region: PRK13189 357809001511 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 357809001512 dimer interface [polypeptide binding]; other site 357809001513 decamer (pentamer of dimers) interface [polypeptide binding]; other site 357809001514 catalytic triad [active] 357809001515 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809001516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357809001517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001518 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357809001519 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809001520 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809001521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 357809001522 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 357809001523 Probable transposase; Region: OrfB_IS605; pfam01385 357809001524 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 357809001525 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 357809001526 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809001527 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 357809001528 dimer interface [polypeptide binding]; other site 357809001529 active site 357809001530 metal binding site [ion binding]; metal-binding site 357809001531 glutathione binding site [chemical binding]; other site 357809001532 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 357809001533 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357809001534 active site 357809001535 HIGH motif; other site 357809001536 nucleotide binding site [chemical binding]; other site 357809001537 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357809001538 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 357809001539 active site 357809001540 KMSKS motif; other site 357809001541 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 357809001542 tRNA binding surface [nucleotide binding]; other site 357809001543 anticodon binding site; other site 357809001544 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 357809001545 Protein of unknown function (DUF342); Region: DUF342; pfam03961 357809001546 TPR repeat; Region: TPR_11; pfam13414 357809001547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809001548 binding surface 357809001549 TPR motif; other site 357809001550 TPR repeat; Region: TPR_11; pfam13414 357809001551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809001552 binding surface 357809001553 TPR motif; other site 357809001554 TPR repeat; Region: TPR_11; pfam13414 357809001555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809001556 binding surface 357809001557 TPR motif; other site 357809001558 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 357809001559 anti sigma factor interaction site; other site 357809001560 regulatory phosphorylation site [posttranslational modification]; other site 357809001561 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 357809001562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809001563 ATP binding site [chemical binding]; other site 357809001564 Mg2+ binding site [ion binding]; other site 357809001565 G-X-G motif; other site 357809001566 sporulation sigma factor SigF; Validated; Region: PRK05572 357809001567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809001568 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357809001569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809001570 DNA binding residues [nucleotide binding] 357809001571 SpoVA protein; Region: SpoVA; pfam03862 357809001572 stage V sporulation protein AD; Provisional; Region: PRK12404 357809001573 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 357809001574 SpoVA protein; Region: SpoVA; pfam03862 357809001575 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 357809001576 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809001577 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809001578 DNA binding site [nucleotide binding] 357809001579 domain linker motif; other site 357809001580 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 357809001581 putative dimerization interface [polypeptide binding]; other site 357809001582 putative ligand binding site [chemical binding]; other site 357809001583 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809001584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001585 dimer interface [polypeptide binding]; other site 357809001586 conserved gate region; other site 357809001587 putative PBP binding loops; other site 357809001588 ABC-ATPase subunit interface; other site 357809001589 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809001590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001591 dimer interface [polypeptide binding]; other site 357809001592 conserved gate region; other site 357809001593 putative PBP binding loops; other site 357809001594 ABC-ATPase subunit interface; other site 357809001595 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809001596 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 357809001597 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 357809001598 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 357809001599 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 357809001600 NADP binding site [chemical binding]; other site 357809001601 homodimer interface [polypeptide binding]; other site 357809001602 active site 357809001603 hypothetical protein; Provisional; Region: PRK09273 357809001604 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 357809001605 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 357809001606 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809001607 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809001608 Alginate lyase; Region: Alginate_lyase2; pfam08787 357809001609 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809001610 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357809001611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809001612 dimerization interface [polypeptide binding]; other site 357809001613 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809001614 dimer interface [polypeptide binding]; other site 357809001615 putative CheW interface [polypeptide binding]; other site 357809001616 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809001617 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809001618 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809001619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809001620 dimerization interface [polypeptide binding]; other site 357809001621 Histidine kinase; Region: His_kinase; pfam06580 357809001622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809001623 ATP binding site [chemical binding]; other site 357809001624 Mg2+ binding site [ion binding]; other site 357809001625 G-X-G motif; other site 357809001626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809001627 active site 357809001628 phosphorylation site [posttranslational modification] 357809001629 intermolecular recognition site; other site 357809001630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809001631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001632 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 357809001633 Transglycosylase; Region: Transgly; pfam00912 357809001634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357809001635 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 357809001636 Transglycosylase; Region: Transgly; pfam00912 357809001637 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357809001638 Uncharacterized conserved protein [Function unknown]; Region: COG1739 357809001639 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 357809001640 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 357809001641 Predicted integral membrane protein [Function unknown]; Region: COG5652 357809001642 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 357809001643 recombination factor protein RarA; Reviewed; Region: PRK13342 357809001644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809001645 Walker A motif; other site 357809001646 ATP binding site [chemical binding]; other site 357809001647 Walker B motif; other site 357809001648 arginine finger; other site 357809001649 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 357809001650 hypothetical protein; Provisional; Region: PRK05590 357809001651 SEC-C motif; Region: SEC-C; pfam02810 357809001652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809001653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809001654 non-specific DNA binding site [nucleotide binding]; other site 357809001655 salt bridge; other site 357809001656 sequence-specific DNA binding site [nucleotide binding]; other site 357809001657 PAS domain; Region: PAS; smart00091 357809001658 PAS domain; Region: PAS_9; pfam13426 357809001659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809001660 dimer interface [polypeptide binding]; other site 357809001661 phosphorylation site [posttranslational modification] 357809001662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809001663 ATP binding site [chemical binding]; other site 357809001664 Mg2+ binding site [ion binding]; other site 357809001665 G-X-G motif; other site 357809001666 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 357809001667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809001668 active site 357809001669 phosphorylation site [posttranslational modification] 357809001670 intermolecular recognition site; other site 357809001671 dimerization interface [polypeptide binding]; other site 357809001672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809001673 Zn2+ binding site [ion binding]; other site 357809001674 Mg2+ binding site [ion binding]; other site 357809001675 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 357809001676 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357809001677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809001678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809001679 DNA binding residues [nucleotide binding] 357809001680 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 357809001681 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357809001682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 357809001683 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 357809001684 NAD(P) binding site [chemical binding]; other site 357809001685 homotetramer interface [polypeptide binding]; other site 357809001686 homodimer interface [polypeptide binding]; other site 357809001687 active site 357809001688 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 357809001689 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357809001690 dimer interface [polypeptide binding]; other site 357809001691 active site 357809001692 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 357809001693 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357809001694 carboxyltransferase (CT) interaction site; other site 357809001695 biotinylation site [posttranslational modification]; other site 357809001696 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 357809001697 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 357809001698 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357809001699 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 357809001700 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 357809001701 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 357809001702 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357809001703 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 357809001704 Rubrerythrin [Energy production and conversion]; Region: COG1592 357809001705 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 357809001706 binuclear metal center [ion binding]; other site 357809001707 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 357809001708 iron binding site [ion binding]; other site 357809001709 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 357809001710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809001711 active site 357809001712 phosphorylation site [posttranslational modification] 357809001713 intermolecular recognition site; other site 357809001714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001715 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809001716 Histidine kinase; Region: His_kinase; pfam06580 357809001717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809001718 ATP binding site [chemical binding]; other site 357809001719 Mg2+ binding site [ion binding]; other site 357809001720 G-X-G motif; other site 357809001721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001722 dimer interface [polypeptide binding]; other site 357809001723 conserved gate region; other site 357809001724 putative PBP binding loops; other site 357809001725 ABC-ATPase subunit interface; other site 357809001726 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809001727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001728 dimer interface [polypeptide binding]; other site 357809001729 conserved gate region; other site 357809001730 putative PBP binding loops; other site 357809001731 ABC-ATPase subunit interface; other site 357809001732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809001733 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 357809001734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809001735 beta-D-glucuronidase; Provisional; Region: PRK10150 357809001736 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357809001737 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357809001738 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357809001739 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 357809001740 substrate binding site [chemical binding]; other site 357809001741 active site 357809001742 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 357809001743 ligand binding site [chemical binding]; other site 357809001744 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 357809001745 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809001746 active site 357809001747 catalytic triad [active] 357809001748 TPR repeat; Region: TPR_11; pfam13414 357809001749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809001750 binding surface 357809001751 TPR motif; other site 357809001752 TPR repeat; Region: TPR_11; pfam13414 357809001753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809001754 binding surface 357809001755 TPR repeat; Region: TPR_11; pfam13414 357809001756 TPR motif; other site 357809001757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357809001758 binding surface 357809001759 TPR motif; other site 357809001760 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 357809001761 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 357809001762 HflX GTPase family; Region: HflX; cd01878 357809001763 G1 box; other site 357809001764 GTP/Mg2+ binding site [chemical binding]; other site 357809001765 Switch I region; other site 357809001766 G2 box; other site 357809001767 G3 box; other site 357809001768 Switch II region; other site 357809001769 G4 box; other site 357809001770 G5 box; other site 357809001771 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 357809001772 ATP cone domain; Region: ATP-cone; pfam03477 357809001773 Class III ribonucleotide reductase; Region: RNR_III; cd01675 357809001774 effector binding site; other site 357809001775 active site 357809001776 Zn binding site [ion binding]; other site 357809001777 glycine loop; other site 357809001778 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357809001779 catalytic residues [active] 357809001780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809001781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809001782 metal binding site [ion binding]; metal-binding site 357809001783 active site 357809001784 I-site; other site 357809001785 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 357809001786 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 357809001787 homodimer interface [polypeptide binding]; other site 357809001788 substrate-cofactor binding pocket; other site 357809001789 catalytic residue [active] 357809001790 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 357809001791 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 357809001792 NodB motif; other site 357809001793 active site 357809001794 catalytic site [active] 357809001795 Zn binding site [ion binding]; other site 357809001796 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357809001797 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 357809001798 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809001799 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 357809001800 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 357809001801 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 357809001802 catalytic site [active] 357809001803 subunit interface [polypeptide binding]; other site 357809001804 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 357809001805 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357809001806 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 357809001807 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 357809001808 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357809001809 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357809001810 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 357809001811 IMP binding site; other site 357809001812 dimer interface [polypeptide binding]; other site 357809001813 interdomain contacts; other site 357809001814 partial ornithine binding site; other site 357809001815 magnesium-transporting ATPase; Provisional; Region: PRK15122 357809001816 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357809001817 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809001818 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357809001819 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357809001820 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809001821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809001822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809001823 DNA binding site [nucleotide binding] 357809001824 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 357809001825 4Fe-4S binding domain; Region: Fer4; pfam00037 357809001826 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357809001827 4Fe-4S binding domain; Region: Fer4_6; pfam12837 357809001828 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 357809001829 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 357809001830 4Fe-4S binding domain; Region: Fer4; pfam00037 357809001831 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357809001832 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 357809001833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809001834 active site 357809001835 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357809001836 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809001837 Zn2+ binding site [ion binding]; other site 357809001838 Mg2+ binding site [ion binding]; other site 357809001839 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357809001840 synthetase active site [active] 357809001841 NTP binding site [chemical binding]; other site 357809001842 metal binding site [ion binding]; metal-binding site 357809001843 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 357809001844 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 357809001845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809001846 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 357809001847 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 357809001848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809001849 FeS/SAM binding site; other site 357809001850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809001851 Zn2+ binding site [ion binding]; other site 357809001852 Mg2+ binding site [ion binding]; other site 357809001853 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 357809001854 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357809001855 dimer interface [polypeptide binding]; other site 357809001856 motif 1; other site 357809001857 active site 357809001858 motif 2; other site 357809001859 motif 3; other site 357809001860 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 357809001861 anticodon binding site; other site 357809001862 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 357809001863 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 357809001864 dimer interface [polypeptide binding]; other site 357809001865 anticodon binding site; other site 357809001866 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 357809001867 homodimer interface [polypeptide binding]; other site 357809001868 motif 1; other site 357809001869 active site 357809001870 motif 2; other site 357809001871 GAD domain; Region: GAD; pfam02938 357809001872 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 357809001873 motif 3; other site 357809001874 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 357809001875 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357809001876 DNA-binding site [nucleotide binding]; DNA binding site 357809001877 RNA-binding motif; other site 357809001878 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 357809001879 active site 357809001880 catalytic residues [active] 357809001881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809001882 active site 357809001883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809001884 Response regulator receiver domain; Region: Response_reg; pfam00072 357809001885 active site 357809001886 phosphorylation site [posttranslational modification] 357809001887 intermolecular recognition site; other site 357809001888 dimerization interface [polypeptide binding]; other site 357809001889 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 357809001890 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 357809001891 putative binding site residues; other site 357809001892 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357809001893 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357809001894 ABC-ATPase subunit interface; other site 357809001895 dimer interface [polypeptide binding]; other site 357809001896 putative PBP binding regions; other site 357809001897 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 357809001898 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357809001899 Walker A/P-loop; other site 357809001900 ATP binding site [chemical binding]; other site 357809001901 Q-loop/lid; other site 357809001902 ABC transporter signature motif; other site 357809001903 Walker B; other site 357809001904 D-loop; other site 357809001905 H-loop/switch region; other site 357809001906 S-layer homology domain; Region: SLH; pfam00395 357809001907 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 357809001908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809001909 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809001910 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 357809001911 dimerization interface [polypeptide binding]; other site 357809001912 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809001913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809001914 dimer interface [polypeptide binding]; other site 357809001915 putative CheW interface [polypeptide binding]; other site 357809001916 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 357809001917 active site 357809001918 catalytic site [active] 357809001919 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809001920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809001921 DNA binding site [nucleotide binding] 357809001922 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809001923 ligand binding site [chemical binding]; other site 357809001924 dimerization interface [polypeptide binding]; other site 357809001925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809001926 active site 357809001927 Phosphotransferase enzyme family; Region: APH; pfam01636 357809001928 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809001929 substrate binding site [chemical binding]; other site 357809001930 UDP-glucose 4-epimerase; Region: PLN02240 357809001931 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 357809001932 NAD binding site [chemical binding]; other site 357809001933 homodimer interface [polypeptide binding]; other site 357809001934 active site 357809001935 substrate binding site [chemical binding]; other site 357809001936 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809001937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001938 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809001939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001940 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 357809001941 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809001942 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 357809001943 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809001944 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809001945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809001946 dimer interface [polypeptide binding]; other site 357809001947 conserved gate region; other site 357809001948 putative PBP binding loops; other site 357809001949 ABC-ATPase subunit interface; other site 357809001950 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 357809001951 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 357809001952 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809001953 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 357809001954 Histidine kinase; Region: His_kinase; pfam06580 357809001955 Response regulator receiver domain; Region: Response_reg; pfam00072 357809001956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809001957 active site 357809001958 phosphorylation site [posttranslational modification] 357809001959 intermolecular recognition site; other site 357809001960 dimerization interface [polypeptide binding]; other site 357809001961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809001962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809001963 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357809001964 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809001965 Walker A/P-loop; other site 357809001966 ATP binding site [chemical binding]; other site 357809001967 Q-loop/lid; other site 357809001968 ABC transporter signature motif; other site 357809001969 Walker B; other site 357809001970 D-loop; other site 357809001971 H-loop/switch region; other site 357809001972 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809001973 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809001974 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809001975 TM-ABC transporter signature motif; other site 357809001976 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809001977 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809001978 TM-ABC transporter signature motif; other site 357809001979 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 357809001980 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 357809001981 ligand binding site [chemical binding]; other site 357809001982 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 357809001983 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 357809001984 hexamer (dimer of trimers) interface [polypeptide binding]; other site 357809001985 substrate binding site [chemical binding]; other site 357809001986 trimer interface [polypeptide binding]; other site 357809001987 Mn binding site [ion binding]; other site 357809001988 DEAD/DEAH box helicase; Region: DEAD; pfam00270 357809001989 ATP binding site [chemical binding]; other site 357809001990 DEAD/DEAH box helicase; Region: DEAD; pfam00270 357809001991 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 357809001992 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 357809001993 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809001994 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809001995 DNA binding site [nucleotide binding] 357809001996 domain linker motif; other site 357809001997 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809001998 dimerization interface [polypeptide binding]; other site 357809001999 ligand binding site [chemical binding]; other site 357809002000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 357809002001 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 357809002002 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809002003 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809002004 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809002005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002006 dimer interface [polypeptide binding]; other site 357809002007 conserved gate region; other site 357809002008 putative PBP binding loops; other site 357809002009 ABC-ATPase subunit interface; other site 357809002010 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809002011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002012 dimer interface [polypeptide binding]; other site 357809002013 conserved gate region; other site 357809002014 ABC-ATPase subunit interface; other site 357809002015 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809002016 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809002017 DNA binding site [nucleotide binding] 357809002018 domain linker motif; other site 357809002019 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809002020 dimerization interface [polypeptide binding]; other site 357809002021 ligand binding site [chemical binding]; other site 357809002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 357809002023 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 357809002024 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 357809002025 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809002026 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809002027 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357809002028 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809002029 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809002030 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357809002031 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809002032 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357809002033 NodB motif; other site 357809002034 active site 357809002035 catalytic site [active] 357809002036 metal binding site [ion binding]; metal-binding site 357809002037 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 357809002038 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 357809002039 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357809002040 PYR/PP interface [polypeptide binding]; other site 357809002041 TPP binding site [chemical binding]; other site 357809002042 dimer interface [polypeptide binding]; other site 357809002043 substrate binding site [chemical binding]; other site 357809002044 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 357809002045 Domain of unknown function; Region: EKR; pfam10371 357809002046 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809002047 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 357809002048 TPP-binding site [chemical binding]; other site 357809002049 dimer interface [polypeptide binding]; other site 357809002050 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 357809002051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357809002052 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809002053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809002054 dimer interface [polypeptide binding]; other site 357809002055 putative CheW interface [polypeptide binding]; other site 357809002056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809002057 dimer interface [polypeptide binding]; other site 357809002058 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357809002059 putative CheW interface [polypeptide binding]; other site 357809002060 purine nucleoside phosphorylase; Provisional; Region: PRK08202 357809002061 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 357809002062 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 357809002063 putative active site [active] 357809002064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809002065 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809002066 Predicted membrane protein [Function unknown]; Region: COG1511 357809002067 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 357809002068 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 357809002069 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 357809002070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809002071 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 357809002072 VanZ like family; Region: VanZ; pfam04892 357809002073 RDD family; Region: RDD; pfam06271 357809002074 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809002075 dimer interface [polypeptide binding]; other site 357809002076 putative CheW interface [polypeptide binding]; other site 357809002077 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809002078 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809002079 dimer interface [polypeptide binding]; other site 357809002080 putative CheW interface [polypeptide binding]; other site 357809002081 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 357809002082 Histidine kinase; Region: His_kinase; pfam06580 357809002083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809002084 ATP binding site [chemical binding]; other site 357809002085 Mg2+ binding site [ion binding]; other site 357809002086 G-X-G motif; other site 357809002087 Response regulator receiver domain; Region: Response_reg; pfam00072 357809002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809002089 active site 357809002090 phosphorylation site [posttranslational modification] 357809002091 intermolecular recognition site; other site 357809002092 dimerization interface [polypeptide binding]; other site 357809002093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809002094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002095 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809002096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809002097 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 357809002098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002099 dimer interface [polypeptide binding]; other site 357809002100 conserved gate region; other site 357809002101 putative PBP binding loops; other site 357809002102 ABC-ATPase subunit interface; other site 357809002103 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809002104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002105 dimer interface [polypeptide binding]; other site 357809002106 conserved gate region; other site 357809002107 putative PBP binding loops; other site 357809002108 ABC-ATPase subunit interface; other site 357809002109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809002110 ATP binding site [chemical binding]; other site 357809002111 Walker A/P-loop; other site 357809002112 Q-loop/lid; other site 357809002113 ABC transporter signature motif; other site 357809002114 Walker B; other site 357809002115 D-loop; other site 357809002116 H-loop/switch region; other site 357809002117 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 357809002118 active site 357809002119 catalytic triad [active] 357809002120 oxyanion hole [active] 357809002121 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 357809002122 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 357809002123 Predicted esterase [General function prediction only]; Region: COG0627 357809002124 Predicted esterase [General function prediction only]; Region: COG0627 357809002125 putative hydrolase; Validated; Region: PRK09248 357809002126 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 357809002127 active site 357809002128 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 357809002129 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 357809002130 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357809002131 ANTAR domain; Region: ANTAR; pfam03861 357809002132 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 357809002133 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 357809002134 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 357809002135 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 357809002136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809002137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809002138 homodimer interface [polypeptide binding]; other site 357809002139 catalytic residue [active] 357809002140 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809002141 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357809002142 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809002143 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357809002144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 357809002145 motif II; other site 357809002146 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809002147 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 357809002148 putative dimer interface [polypeptide binding]; other site 357809002149 catalytic triad [active] 357809002150 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 357809002151 Sulfatase; Region: Sulfatase; cl17466 357809002152 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 357809002153 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 357809002154 putative dimer interface [polypeptide binding]; other site 357809002155 putative anticodon binding site; other site 357809002156 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357809002157 motif 1; other site 357809002158 dimer interface [polypeptide binding]; other site 357809002159 active site 357809002160 motif 2; other site 357809002161 motif 3; other site 357809002162 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 357809002163 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 357809002164 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 357809002165 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 357809002166 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 357809002167 GatB domain; Region: GatB_Yqey; smart00845 357809002168 PilZ domain; Region: PilZ; pfam07238 357809002169 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 357809002170 DHH family; Region: DHH; pfam01368 357809002171 DHHA1 domain; Region: DHHA1; pfam02272 357809002172 Src Homology 3 domain superfamily; Region: SH3; cl17036 357809002173 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 357809002174 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 357809002175 purine monophosphate binding site [chemical binding]; other site 357809002176 dimer interface [polypeptide binding]; other site 357809002177 putative catalytic residues [active] 357809002178 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 357809002179 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 357809002180 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357809002181 DNA-binding site [nucleotide binding]; DNA binding site 357809002182 RNA-binding motif; other site 357809002183 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 357809002184 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 357809002185 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 357809002186 Peptidase M16C associated; Region: M16C_assoc; pfam08367 357809002187 GTPase Era; Reviewed; Region: era; PRK00089 357809002188 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 357809002189 G1 box; other site 357809002190 GTP/Mg2+ binding site [chemical binding]; other site 357809002191 Switch I region; other site 357809002192 G2 box; other site 357809002193 Switch II region; other site 357809002194 G3 box; other site 357809002195 G4 box; other site 357809002196 G5 box; other site 357809002197 KH domain; Region: KH_2; pfam07650 357809002198 Recombination protein O N terminal; Region: RecO_N; pfam11967 357809002199 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 357809002200 Recombination protein O C terminal; Region: RecO_C; pfam02565 357809002201 glycyl-tRNA synthetase; Provisional; Region: PRK04173 357809002202 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357809002203 motif 1; other site 357809002204 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 357809002205 active site 357809002206 motif 2; other site 357809002207 motif 3; other site 357809002208 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 357809002209 anticodon binding site; other site 357809002210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809002211 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809002212 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 357809002213 active site 357809002214 catalytic triad [active] 357809002215 oxyanion hole [active] 357809002216 pyruvate phosphate dikinase; Provisional; Region: PRK09279 357809002217 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 357809002218 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357809002219 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357809002220 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 357809002221 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 357809002222 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 357809002223 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 357809002224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809002225 DNA-binding site [nucleotide binding]; DNA binding site 357809002226 FCD domain; Region: FCD; pfam07729 357809002227 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 357809002228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809002229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809002230 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 357809002231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809002232 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 357809002233 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 357809002234 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357809002235 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357809002236 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809002237 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809002238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002239 dimer interface [polypeptide binding]; other site 357809002240 conserved gate region; other site 357809002241 putative PBP binding loops; other site 357809002242 ABC-ATPase subunit interface; other site 357809002243 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809002244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002245 dimer interface [polypeptide binding]; other site 357809002246 conserved gate region; other site 357809002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809002248 ABC-ATPase subunit interface; other site 357809002249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809002250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809002251 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 357809002252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357809002253 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 357809002254 putative ligand binding site [chemical binding]; other site 357809002255 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 357809002256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809002257 S-adenosylmethionine binding site [chemical binding]; other site 357809002258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809002259 WHG domain; Region: WHG; pfam13305 357809002260 CAAX protease self-immunity; Region: Abi; pfam02517 357809002261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809002262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002263 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 357809002264 dimer interface [polypeptide binding]; other site 357809002265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809002266 ligand binding site [chemical binding]; other site 357809002267 Predicted acetyltransferase [General function prediction only]; Region: COG5628 357809002268 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809002269 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809002270 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357809002271 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 357809002272 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 357809002273 active site 357809002274 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 357809002275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809002276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809002277 DNA binding residues [nucleotide binding] 357809002278 Double zinc ribbon; Region: DZR; pfam12773 357809002279 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 357809002280 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 357809002281 PDGLE domain; Region: PDGLE; pfam13190 357809002282 Urea transporter; Region: UT; cl01829 357809002283 UreD urease accessory protein; Region: UreD; pfam01774 357809002284 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809002285 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 357809002286 UreF; Region: UreF; pfam01730 357809002287 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 357809002288 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 357809002289 dimer interface [polypeptide binding]; other site 357809002290 catalytic residues [active] 357809002291 urease subunit alpha; Reviewed; Region: ureC; PRK13207 357809002292 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 357809002293 subunit interactions [polypeptide binding]; other site 357809002294 active site 357809002295 flap region; other site 357809002296 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 357809002297 gamma-beta subunit interface [polypeptide binding]; other site 357809002298 alpha-beta subunit interface [polypeptide binding]; other site 357809002299 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 357809002300 alpha-gamma subunit interface [polypeptide binding]; other site 357809002301 beta-gamma subunit interface [polypeptide binding]; other site 357809002302 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 357809002303 putative homodimer interface [polypeptide binding]; other site 357809002304 putative homotetramer interface [polypeptide binding]; other site 357809002305 putative metal binding site [ion binding]; other site 357809002306 putative homodimer-homodimer interface [polypeptide binding]; other site 357809002307 putative allosteric switch controlling residues; other site 357809002308 Cobalt transport protein; Region: CbiQ; cl00463 357809002309 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809002310 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357809002311 Walker A/P-loop; other site 357809002312 ATP binding site [chemical binding]; other site 357809002313 Q-loop/lid; other site 357809002314 ABC transporter signature motif; other site 357809002315 Walker B; other site 357809002316 D-loop; other site 357809002317 H-loop/switch region; other site 357809002318 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 357809002319 putative catalytic site [active] 357809002320 putative metal binding site [ion binding]; other site 357809002321 putative phosphate binding site [ion binding]; other site 357809002322 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 357809002323 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809002324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002325 dimer interface [polypeptide binding]; other site 357809002326 conserved gate region; other site 357809002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809002328 ABC-ATPase subunit interface; other site 357809002329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002331 ABC-ATPase subunit interface; other site 357809002332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809002333 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 357809002334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809002335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809002336 DNA binding site [nucleotide binding] 357809002337 domain linker motif; other site 357809002338 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809002339 dimerization interface [polypeptide binding]; other site 357809002340 ligand binding site [chemical binding]; other site 357809002341 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 357809002342 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357809002343 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357809002344 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 357809002345 trimer interface [polypeptide binding]; other site 357809002346 putative Zn binding site [ion binding]; other site 357809002347 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 357809002348 putative metal binding residues [ion binding]; other site 357809002349 signature motif; other site 357809002350 dimer interface [polypeptide binding]; other site 357809002351 active site 357809002352 polyP binding site; other site 357809002353 substrate binding site [chemical binding]; other site 357809002354 acceptor-phosphate pocket; other site 357809002355 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 357809002356 CotH protein; Region: CotH; pfam08757 357809002357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809002358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809002359 active site 357809002360 phosphorylation site [posttranslational modification] 357809002361 intermolecular recognition site; other site 357809002362 dimerization interface [polypeptide binding]; other site 357809002363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809002364 DNA binding site [nucleotide binding] 357809002365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809002366 HAMP domain; Region: HAMP; pfam00672 357809002367 dimerization interface [polypeptide binding]; other site 357809002368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809002369 dimer interface [polypeptide binding]; other site 357809002370 phosphorylation site [posttranslational modification] 357809002371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809002372 ATP binding site [chemical binding]; other site 357809002373 Mg2+ binding site [ion binding]; other site 357809002374 G-X-G motif; other site 357809002375 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 357809002376 LrgB-like family; Region: LrgB; pfam04172 357809002377 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 357809002378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809002379 ATP binding site [chemical binding]; other site 357809002380 putative Mg++ binding site [ion binding]; other site 357809002381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809002382 nucleotide binding region [chemical binding]; other site 357809002383 ATP-binding site [chemical binding]; other site 357809002384 DEAD/H associated; Region: DEAD_assoc; pfam08494 357809002385 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809002386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809002388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002389 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357809002390 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 357809002391 putative NAD(P) binding site [chemical binding]; other site 357809002392 active site 357809002393 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357809002394 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357809002395 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357809002396 phosphodiesterase; Provisional; Region: PRK12704 357809002397 ZIP Zinc transporter; Region: Zip; pfam02535 357809002398 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 357809002399 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 357809002400 transcription elongation factor GreA; Region: greA; TIGR01462 357809002401 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 357809002402 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 357809002403 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 357809002404 Protein export membrane protein; Region: SecD_SecF; cl14618 357809002405 Domain of unknown function (DUF368); Region: DUF368; pfam04018 357809002406 Predicted membrane protein [Function unknown]; Region: COG2323 357809002407 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 357809002408 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 357809002409 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 357809002410 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 357809002411 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809002412 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 357809002413 NlpC/P60 family; Region: NLPC_P60; pfam00877 357809002414 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 357809002415 ArsC family; Region: ArsC; pfam03960 357809002416 catalytic residue [active] 357809002417 Predicted membrane protein [Function unknown]; Region: COG2364 357809002418 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 357809002419 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357809002420 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357809002421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357809002422 ABC-ATPase subunit interface; other site 357809002423 dimer interface [polypeptide binding]; other site 357809002424 putative PBP binding regions; other site 357809002425 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357809002426 ABC-ATPase subunit interface; other site 357809002427 dimer interface [polypeptide binding]; other site 357809002428 putative PBP binding regions; other site 357809002429 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 357809002430 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357809002431 Walker A/P-loop; other site 357809002432 ATP binding site [chemical binding]; other site 357809002433 Q-loop/lid; other site 357809002434 ABC transporter signature motif; other site 357809002435 Walker B; other site 357809002436 D-loop; other site 357809002437 H-loop/switch region; other site 357809002438 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 357809002439 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 357809002440 putative ligand binding residues [chemical binding]; other site 357809002441 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357809002442 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357809002443 catalytic residues [active] 357809002444 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 357809002445 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 357809002446 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357809002447 active site residue [active] 357809002448 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809002449 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 357809002450 DNA binding residues [nucleotide binding] 357809002451 putative dimer interface [polypeptide binding]; other site 357809002452 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357809002453 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357809002454 catalytic residues [active] 357809002455 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357809002456 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357809002457 ligand binding site [chemical binding]; other site 357809002458 flexible hinge region; other site 357809002459 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357809002460 putative switch regulator; other site 357809002461 non-specific DNA interactions [nucleotide binding]; other site 357809002462 DNA binding site [nucleotide binding] 357809002463 sequence specific DNA binding site [nucleotide binding]; other site 357809002464 putative cAMP binding site [chemical binding]; other site 357809002465 pyruvate kinase; Provisional; Region: PRK06354 357809002466 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 357809002467 domain interfaces; other site 357809002468 active site 357809002469 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 357809002470 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809002471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809002472 active site 357809002473 phosphorylation site [posttranslational modification] 357809002474 intermolecular recognition site; other site 357809002475 dimerization interface [polypeptide binding]; other site 357809002476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809002477 DNA binding site [nucleotide binding] 357809002478 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 357809002479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809002480 dimer interface [polypeptide binding]; other site 357809002481 phosphorylation site [posttranslational modification] 357809002482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809002483 ATP binding site [chemical binding]; other site 357809002484 Mg2+ binding site [ion binding]; other site 357809002485 G-X-G motif; other site 357809002486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809002487 AAA domain; Region: AAA_21; pfam13304 357809002488 Walker A/P-loop; other site 357809002489 ATP binding site [chemical binding]; other site 357809002490 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 357809002491 dimer interface [polypeptide binding]; other site 357809002492 catalytic triad [active] 357809002493 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357809002494 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809002495 Zn2+ binding site [ion binding]; other site 357809002496 Mg2+ binding site [ion binding]; other site 357809002497 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 357809002498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809002499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809002500 Coenzyme A binding pocket [chemical binding]; other site 357809002501 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 357809002502 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 357809002503 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 357809002504 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357809002505 motif 1; other site 357809002506 dimer interface [polypeptide binding]; other site 357809002507 active site 357809002508 motif 2; other site 357809002509 motif 3; other site 357809002510 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 357809002511 anticodon binding site; other site 357809002512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357809002513 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809002514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809002515 dimer interface [polypeptide binding]; other site 357809002516 putative CheW interface [polypeptide binding]; other site 357809002517 trigger factor; Region: tig; TIGR00115 357809002518 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357809002519 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 357809002520 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 357809002521 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 357809002522 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 357809002523 intersubunit interface [polypeptide binding]; other site 357809002524 active site 357809002525 catalytic residue [active] 357809002526 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 357809002527 active site 357809002528 catalytic motif [active] 357809002529 Zn binding site [ion binding]; other site 357809002530 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 357809002531 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 357809002532 ligand binding site [chemical binding]; other site 357809002533 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 357809002534 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809002535 Walker A/P-loop; other site 357809002536 ATP binding site [chemical binding]; other site 357809002537 Q-loop/lid; other site 357809002538 ABC transporter signature motif; other site 357809002539 Walker B; other site 357809002540 D-loop; other site 357809002541 H-loop/switch region; other site 357809002542 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809002543 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809002544 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809002545 TM-ABC transporter signature motif; other site 357809002546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809002547 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809002548 TM-ABC transporter signature motif; other site 357809002549 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 357809002550 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 357809002551 active site 357809002552 Zn binding site [ion binding]; other site 357809002553 Uncharacterized conserved protein [Function unknown]; Region: COG1284 357809002554 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809002555 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 357809002556 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 357809002557 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 357809002558 active site 357809002559 HIGH motif; other site 357809002560 dimer interface [polypeptide binding]; other site 357809002561 KMSKS motif; other site 357809002562 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809002563 RNA binding surface [nucleotide binding]; other site 357809002564 Protein of unknown function (DUF998); Region: DUF998; pfam06197 357809002565 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 357809002566 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 357809002567 putative ligand binding site [chemical binding]; other site 357809002568 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 357809002569 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809002570 Walker A/P-loop; other site 357809002571 ATP binding site [chemical binding]; other site 357809002572 Q-loop/lid; other site 357809002573 ABC transporter signature motif; other site 357809002574 Walker B; other site 357809002575 D-loop; other site 357809002576 H-loop/switch region; other site 357809002577 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809002578 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809002579 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809002580 TM-ABC transporter signature motif; other site 357809002581 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809002582 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809002583 TM-ABC transporter signature motif; other site 357809002584 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809002585 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809002586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002587 alpha-galactosidase; Provisional; Region: PRK15076 357809002588 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 357809002589 NAD binding site [chemical binding]; other site 357809002590 sugar binding site [chemical binding]; other site 357809002591 divalent metal binding site [ion binding]; other site 357809002592 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 357809002593 dimer interface [polypeptide binding]; other site 357809002594 Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994 357809002595 active site 357809002596 Response regulator receiver domain; Region: Response_reg; pfam00072 357809002597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809002598 active site 357809002599 phosphorylation site [posttranslational modification] 357809002600 intermolecular recognition site; other site 357809002601 dimerization interface [polypeptide binding]; other site 357809002602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002603 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809002604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809002606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809002607 dimerization interface [polypeptide binding]; other site 357809002608 Histidine kinase; Region: His_kinase; pfam06580 357809002609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809002610 ATP binding site [chemical binding]; other site 357809002611 Mg2+ binding site [ion binding]; other site 357809002612 G-X-G motif; other site 357809002613 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809002614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002615 ABC-ATPase subunit interface; other site 357809002616 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809002617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002618 dimer interface [polypeptide binding]; other site 357809002619 ABC-ATPase subunit interface; other site 357809002620 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809002621 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 357809002622 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 357809002623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809002624 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 357809002625 active site 357809002626 motif I; other site 357809002627 motif II; other site 357809002628 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 357809002629 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 357809002630 Domain of unknown function (DUF955); Region: DUF955; cl01076 357809002631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809002632 non-specific DNA binding site [nucleotide binding]; other site 357809002633 salt bridge; other site 357809002634 sequence-specific DNA binding site [nucleotide binding]; other site 357809002635 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 357809002636 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 357809002637 Phage XkdN-like protein; Region: XkdN; pfam08890 357809002638 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 357809002639 dimer interface [polypeptide binding]; other site 357809002640 tape measure domain; Region: tape_meas_nterm; TIGR02675 357809002641 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809002642 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 357809002643 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 357809002644 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 357809002645 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 357809002646 Holin family; Region: Phage_holin_4; pfam05105 357809002647 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357809002648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809002649 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357809002650 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357809002651 Walker A/P-loop; other site 357809002652 ATP binding site [chemical binding]; other site 357809002653 Q-loop/lid; other site 357809002654 ABC transporter signature motif; other site 357809002655 Walker B; other site 357809002656 D-loop; other site 357809002657 H-loop/switch region; other site 357809002658 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 357809002659 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 357809002660 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357809002661 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 357809002662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357809002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002664 dimer interface [polypeptide binding]; other site 357809002665 conserved gate region; other site 357809002666 putative PBP binding loops; other site 357809002667 ABC-ATPase subunit interface; other site 357809002668 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 357809002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002670 dimer interface [polypeptide binding]; other site 357809002671 conserved gate region; other site 357809002672 putative PBP binding loops; other site 357809002673 ABC-ATPase subunit interface; other site 357809002674 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357809002675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809002676 Walker A/P-loop; other site 357809002677 ATP binding site [chemical binding]; other site 357809002678 Q-loop/lid; other site 357809002679 ABC transporter signature motif; other site 357809002680 Walker B; other site 357809002681 D-loop; other site 357809002682 H-loop/switch region; other site 357809002683 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357809002684 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 357809002685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809002686 Walker A/P-loop; other site 357809002687 ATP binding site [chemical binding]; other site 357809002688 Q-loop/lid; other site 357809002689 ABC transporter signature motif; other site 357809002690 Walker B; other site 357809002691 D-loop; other site 357809002692 H-loop/switch region; other site 357809002693 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357809002694 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 357809002695 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357809002696 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 357809002697 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357809002698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002699 dimer interface [polypeptide binding]; other site 357809002700 conserved gate region; other site 357809002701 putative PBP binding loops; other site 357809002702 ABC-ATPase subunit interface; other site 357809002703 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 357809002704 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 357809002705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002706 dimer interface [polypeptide binding]; other site 357809002707 conserved gate region; other site 357809002708 putative PBP binding loops; other site 357809002709 ABC-ATPase subunit interface; other site 357809002710 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 357809002711 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357809002712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809002713 Walker A/P-loop; other site 357809002714 ATP binding site [chemical binding]; other site 357809002715 Q-loop/lid; other site 357809002716 ABC transporter signature motif; other site 357809002717 Walker B; other site 357809002718 D-loop; other site 357809002719 H-loop/switch region; other site 357809002720 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357809002721 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 357809002722 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809002723 Walker A/P-loop; other site 357809002724 ATP binding site [chemical binding]; other site 357809002725 Q-loop/lid; other site 357809002726 ABC transporter signature motif; other site 357809002727 Walker B; other site 357809002728 D-loop; other site 357809002729 H-loop/switch region; other site 357809002730 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357809002731 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 357809002732 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 357809002733 A new structural DNA glycosylase; Region: AlkD_like; cd06561 357809002734 active site 357809002735 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 357809002736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809002737 motif II; other site 357809002738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357809002739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809002740 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 357809002741 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 357809002742 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 357809002743 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 357809002744 putative active site [active] 357809002745 putative metal binding residues [ion binding]; other site 357809002746 signature motif; other site 357809002747 putative dimer interface [polypeptide binding]; other site 357809002748 putative phosphate binding site [ion binding]; other site 357809002749 glutamate dehydrogenase; Provisional; Region: PRK09414 357809002750 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 357809002751 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 357809002752 NAD(P) binding site [chemical binding]; other site 357809002753 Spore germination protein; Region: Spore_permease; cl17796 357809002754 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 357809002755 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 357809002756 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 357809002757 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357809002758 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357809002759 catalytic residues [active] 357809002760 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 357809002761 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 357809002762 Uncharacterized conserved protein [Function unknown]; Region: COG1434 357809002763 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 357809002764 putative active site [active] 357809002765 SAF domain; Region: SAF; pfam08666 357809002766 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357809002767 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357809002768 Walker A motif; other site 357809002769 ATP binding site [chemical binding]; other site 357809002770 Walker B motif; other site 357809002771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357809002772 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357809002773 membrane-bound complex binding site; other site 357809002774 hinge residues; other site 357809002775 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357809002776 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357809002777 substrate binding pocket [chemical binding]; other site 357809002778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002779 dimer interface [polypeptide binding]; other site 357809002780 conserved gate region; other site 357809002781 putative PBP binding loops; other site 357809002782 ABC-ATPase subunit interface; other site 357809002783 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357809002784 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357809002785 Walker A/P-loop; other site 357809002786 ATP binding site [chemical binding]; other site 357809002787 Q-loop/lid; other site 357809002788 ABC transporter signature motif; other site 357809002789 Walker B; other site 357809002790 D-loop; other site 357809002791 H-loop/switch region; other site 357809002792 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357809002793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809002794 active site 357809002795 phosphorylation site [posttranslational modification] 357809002796 intermolecular recognition site; other site 357809002797 dimerization interface [polypeptide binding]; other site 357809002798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357809002799 DNA binding residues [nucleotide binding] 357809002800 dimerization interface [polypeptide binding]; other site 357809002801 Histidine kinase; Region: HisKA_3; pfam07730 357809002802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357809002803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809002804 ATP binding site [chemical binding]; other site 357809002805 Mg2+ binding site [ion binding]; other site 357809002806 G-X-G motif; other site 357809002807 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357809002808 MarR family; Region: MarR_2; pfam12802 357809002809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809002810 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809002811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809002812 Walker A/P-loop; other site 357809002813 ATP binding site [chemical binding]; other site 357809002814 Q-loop/lid; other site 357809002815 ABC transporter signature motif; other site 357809002816 Walker B; other site 357809002817 D-loop; other site 357809002818 H-loop/switch region; other site 357809002819 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809002820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809002821 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809002822 Walker A/P-loop; other site 357809002823 ATP binding site [chemical binding]; other site 357809002824 Q-loop/lid; other site 357809002825 ABC transporter signature motif; other site 357809002826 Walker B; other site 357809002827 D-loop; other site 357809002828 H-loop/switch region; other site 357809002829 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 357809002830 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 357809002831 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 357809002832 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809002833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002834 dimer interface [polypeptide binding]; other site 357809002835 conserved gate region; other site 357809002836 ABC-ATPase subunit interface; other site 357809002837 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809002838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809002839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002840 ABC-ATPase subunit interface; other site 357809002841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809002842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809002843 dimerization interface [polypeptide binding]; other site 357809002844 Histidine kinase; Region: His_kinase; pfam06580 357809002845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809002846 ATP binding site [chemical binding]; other site 357809002847 Mg2+ binding site [ion binding]; other site 357809002848 G-X-G motif; other site 357809002849 Response regulator receiver domain; Region: Response_reg; pfam00072 357809002850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809002851 active site 357809002852 phosphorylation site [posttranslational modification] 357809002853 intermolecular recognition site; other site 357809002854 dimerization interface [polypeptide binding]; other site 357809002855 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809002856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809002857 Beta-lactamase; Region: Beta-lactamase; pfam00144 357809002858 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357809002859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809002860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809002861 active site 357809002862 phosphorylation site [posttranslational modification] 357809002863 intermolecular recognition site; other site 357809002864 dimerization interface [polypeptide binding]; other site 357809002865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809002866 DNA binding site [nucleotide binding] 357809002867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809002868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809002869 dimer interface [polypeptide binding]; other site 357809002870 phosphorylation site [posttranslational modification] 357809002871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809002872 ATP binding site [chemical binding]; other site 357809002873 Mg2+ binding site [ion binding]; other site 357809002874 G-X-G motif; other site 357809002875 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809002876 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809002877 six-cysteine peptide SCIFF; Region: six_Cys_in_45; TIGR03973 357809002878 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 357809002879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809002880 FeS/SAM binding site; other site 357809002881 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 357809002882 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357809002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809002884 S-adenosylmethionine binding site [chemical binding]; other site 357809002885 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357809002886 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357809002887 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 357809002888 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 357809002889 inhibitor binding site; inhibition site 357809002890 active site 357809002891 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 357809002892 DHH family; Region: DHH; pfam01368 357809002893 DHHA1 domain; Region: DHHA1; pfam02272 357809002894 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 357809002895 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 357809002896 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 357809002897 dimerization interface 3.5A [polypeptide binding]; other site 357809002898 active site 357809002899 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 357809002900 nudix motif; other site 357809002901 dihydroorotase; Validated; Region: pyrC; PRK09357 357809002902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357809002903 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 357809002904 active site 357809002905 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 357809002906 active site 357809002907 dimer interface [polypeptide binding]; other site 357809002908 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809002909 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809002910 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 357809002911 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 357809002912 Competence protein CoiA-like family; Region: CoiA; cl11541 357809002913 beta-D-glucuronidase; Provisional; Region: PRK10150 357809002914 S-ribosylhomocysteinase; Provisional; Region: PRK02260 357809002915 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 357809002916 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 357809002917 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 357809002918 putative ligand binding site [chemical binding]; other site 357809002919 putative NAD binding site [chemical binding]; other site 357809002920 catalytic site [active] 357809002921 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 357809002922 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 357809002923 tetramer interface [polypeptide binding]; other site 357809002924 heme binding pocket [chemical binding]; other site 357809002925 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 357809002926 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 357809002927 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357809002928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002929 dimer interface [polypeptide binding]; other site 357809002930 conserved gate region; other site 357809002931 putative PBP binding loops; other site 357809002932 ABC-ATPase subunit interface; other site 357809002933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809002934 putative PBP binding loops; other site 357809002935 dimer interface [polypeptide binding]; other site 357809002936 ABC-ATPase subunit interface; other site 357809002937 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357809002938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809002939 Walker A/P-loop; other site 357809002940 ATP binding site [chemical binding]; other site 357809002941 Q-loop/lid; other site 357809002942 ABC transporter signature motif; other site 357809002943 Walker B; other site 357809002944 D-loop; other site 357809002945 H-loop/switch region; other site 357809002946 TOBE domain; Region: TOBE_2; pfam08402 357809002947 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 357809002948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809002949 non-specific DNA binding site [nucleotide binding]; other site 357809002950 salt bridge; other site 357809002951 sequence-specific DNA binding site [nucleotide binding]; other site 357809002952 Cupin domain; Region: Cupin_2; pfam07883 357809002953 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809002954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809002955 Walker A/P-loop; other site 357809002956 ATP binding site [chemical binding]; other site 357809002957 Q-loop/lid; other site 357809002958 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809002959 ABC transporter signature motif; other site 357809002960 Walker B; other site 357809002961 D-loop; other site 357809002962 ABC transporter; Region: ABC_tran_2; pfam12848 357809002963 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809002964 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 357809002965 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 357809002966 CoA binding domain; Region: CoA_binding; pfam02629 357809002967 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 357809002968 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 357809002969 putative carbohydrate kinase; Provisional; Region: PRK10565 357809002970 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 357809002971 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 357809002972 putative substrate binding site [chemical binding]; other site 357809002973 putative ATP binding site [chemical binding]; other site 357809002974 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 357809002975 alanine racemase; Reviewed; Region: alr; PRK00053 357809002976 active site 357809002977 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357809002978 dimer interface [polypeptide binding]; other site 357809002979 substrate binding site [chemical binding]; other site 357809002980 catalytic residues [active] 357809002981 PemK-like protein; Region: PemK; pfam02452 357809002982 Domain of unknown function DUF21; Region: DUF21; pfam01595 357809002983 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 357809002984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357809002985 Transporter associated domain; Region: CorC_HlyC; pfam03471 357809002986 Uncharacterized conserved protein [Function unknown]; Region: COG2966 357809002987 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 357809002988 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 357809002989 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 357809002990 YcxB-like protein; Region: YcxB; pfam14317 357809002991 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357809002992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809002993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809002994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809002995 Walker A/P-loop; other site 357809002996 ATP binding site [chemical binding]; other site 357809002997 Q-loop/lid; other site 357809002998 ABC transporter signature motif; other site 357809002999 Walker B; other site 357809003000 D-loop; other site 357809003001 H-loop/switch region; other site 357809003002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809003003 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809003004 SIR2-like domain; Region: SIR2_2; pfam13289 357809003005 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809003006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809003007 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809003008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003009 dimer interface [polypeptide binding]; other site 357809003010 conserved gate region; other site 357809003011 putative PBP binding loops; other site 357809003012 ABC-ATPase subunit interface; other site 357809003013 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809003014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003015 dimer interface [polypeptide binding]; other site 357809003016 ABC-ATPase subunit interface; other site 357809003017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809003018 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 357809003019 substrate binding site [chemical binding]; other site 357809003020 catalytic residues [active] 357809003021 Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994 357809003022 active site 357809003023 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 357809003024 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 357809003025 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 357809003026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 357809003027 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 357809003028 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809003029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003030 Walker A/P-loop; other site 357809003031 ATP binding site [chemical binding]; other site 357809003032 Q-loop/lid; other site 357809003033 ABC transporter signature motif; other site 357809003034 Walker B; other site 357809003035 D-loop; other site 357809003036 H-loop/switch region; other site 357809003037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809003038 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 357809003039 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 357809003040 HIGH motif; other site 357809003041 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357809003042 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357809003043 KMSKS motif; other site 357809003044 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 357809003045 tRNA binding surface [nucleotide binding]; other site 357809003046 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809003047 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357809003048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809003049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809003050 DNA binding residues [nucleotide binding] 357809003051 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809003052 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 357809003053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809003054 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 357809003055 DNA binding residues [nucleotide binding] 357809003056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809003057 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 357809003058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809003059 Coenzyme A binding pocket [chemical binding]; other site 357809003060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809003061 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357809003062 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 357809003063 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809003064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809003065 non-specific DNA binding site [nucleotide binding]; other site 357809003066 salt bridge; other site 357809003067 sequence-specific DNA binding site [nucleotide binding]; other site 357809003068 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357809003069 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 357809003070 Metal-binding active site; metal-binding site 357809003071 alanyl-tRNA synthetase; Provisional; Region: PRK01584 357809003072 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 357809003073 motif 1; other site 357809003074 active site 357809003075 motif 2; other site 357809003076 motif 3; other site 357809003077 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357809003078 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 357809003079 P-loop containing region of AAA domain; Region: AAA_29; cl17516 357809003080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003081 ABC transporter signature motif; other site 357809003082 Walker B; other site 357809003083 D-loop; other site 357809003084 H-loop/switch region; other site 357809003085 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 357809003086 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357809003087 NAD(P) binding site [chemical binding]; other site 357809003088 catalytic residues [active] 357809003089 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 357809003090 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 357809003091 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357809003092 minor groove reading motif; other site 357809003093 helix-hairpin-helix signature motif; other site 357809003094 substrate binding pocket [chemical binding]; other site 357809003095 active site 357809003096 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809003097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003098 Walker A/P-loop; other site 357809003099 ATP binding site [chemical binding]; other site 357809003100 Q-loop/lid; other site 357809003101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809003102 ABC transporter signature motif; other site 357809003103 Walker B; other site 357809003104 D-loop; other site 357809003105 ABC transporter; Region: ABC_tran_2; pfam12848 357809003106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809003107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357809003108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809003109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809003110 active site 357809003111 phosphorylation site [posttranslational modification] 357809003112 intermolecular recognition site; other site 357809003113 dimerization interface [polypeptide binding]; other site 357809003114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809003115 DNA binding site [nucleotide binding] 357809003116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357809003117 dimerization interface [polypeptide binding]; other site 357809003118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809003119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809003120 dimer interface [polypeptide binding]; other site 357809003121 phosphorylation site [posttranslational modification] 357809003122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809003123 ATP binding site [chemical binding]; other site 357809003124 Mg2+ binding site [ion binding]; other site 357809003125 G-X-G motif; other site 357809003126 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 357809003127 active site 357809003128 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 357809003129 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 357809003130 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 357809003131 4Fe-4S binding domain; Region: Fer4; pfam00037 357809003132 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 357809003133 Nitroreductase family; Region: Nitroreductase; pfam00881 357809003134 FMN binding site [chemical binding]; other site 357809003135 dimer interface [polypeptide binding]; other site 357809003136 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357809003137 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 357809003138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809003139 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809003140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809003141 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 357809003142 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 357809003143 oligomer interface [polypeptide binding]; other site 357809003144 active site residues [active] 357809003145 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357809003146 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357809003147 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 357809003148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809003149 active site 357809003150 phosphorylation site [posttranslational modification] 357809003151 intermolecular recognition site; other site 357809003152 dimerization interface [polypeptide binding]; other site 357809003153 LytTr DNA-binding domain; Region: LytTR; smart00850 357809003154 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 357809003155 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 357809003156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003157 Walker A/P-loop; other site 357809003158 ATP binding site [chemical binding]; other site 357809003159 Q-loop/lid; other site 357809003160 ABC transporter signature motif; other site 357809003161 Walker B; other site 357809003162 D-loop; other site 357809003163 H-loop/switch region; other site 357809003164 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 357809003165 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 357809003166 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 357809003167 Protein of unknown function (DUF3201); Region: DUF3201; pfam11447 357809003168 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 357809003169 active site 357809003170 putative catalytic site [active] 357809003171 DNA binding site [nucleotide binding] 357809003172 putative phosphate binding site [ion binding]; other site 357809003173 metal binding site A [ion binding]; metal-binding site 357809003174 AP binding site [nucleotide binding]; other site 357809003175 metal binding site B [ion binding]; metal-binding site 357809003176 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 357809003177 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 357809003178 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 357809003179 non-heme iron binding site [ion binding]; other site 357809003180 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357809003181 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357809003182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809003183 DNA-binding site [nucleotide binding]; DNA binding site 357809003184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809003185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809003186 homodimer interface [polypeptide binding]; other site 357809003187 catalytic residue [active] 357809003188 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 357809003189 dimer interface [polypeptide binding]; other site 357809003190 substrate binding site [chemical binding]; other site 357809003191 ATP binding site [chemical binding]; other site 357809003192 Predicted transcriptional regulator [Transcription]; Region: COG2378 357809003193 HTH domain; Region: HTH_11; pfam08279 357809003194 WYL domain; Region: WYL; pfam13280 357809003195 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 357809003196 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357809003197 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 357809003198 hypothetical protein; Validated; Region: PRK00029 357809003199 Uncharacterized conserved protein [Function unknown]; Region: COG0397 357809003200 Predicted membrane protein [Function unknown]; Region: COG2860 357809003201 UPF0126 domain; Region: UPF0126; pfam03458 357809003202 UPF0126 domain; Region: UPF0126; pfam03458 357809003203 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 357809003204 Predicted membrane protein [Function unknown]; Region: COG1288 357809003205 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 357809003206 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 357809003207 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 357809003208 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 357809003209 FMN-binding domain; Region: FMN_bind; pfam04205 357809003210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809003211 dimerization interface [polypeptide binding]; other site 357809003212 putative DNA binding site [nucleotide binding]; other site 357809003213 putative Zn2+ binding site [ion binding]; other site 357809003214 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357809003215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003216 Walker A/P-loop; other site 357809003217 ATP binding site [chemical binding]; other site 357809003218 Q-loop/lid; other site 357809003219 ABC transporter signature motif; other site 357809003220 Walker B; other site 357809003221 D-loop; other site 357809003222 H-loop/switch region; other site 357809003223 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809003224 ABC-2 type transporter; Region: ABC2_membrane; cl17235 357809003225 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357809003226 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 357809003227 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357809003228 DNA binding residues [nucleotide binding] 357809003229 dimer interface [polypeptide binding]; other site 357809003230 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 357809003231 histidyl-tRNA synthetase; Region: hisS; TIGR00442 357809003232 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357809003233 dimer interface [polypeptide binding]; other site 357809003234 motif 1; other site 357809003235 active site 357809003236 motif 2; other site 357809003237 motif 3; other site 357809003238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809003239 non-specific DNA binding site [nucleotide binding]; other site 357809003240 salt bridge; other site 357809003241 sequence-specific DNA binding site [nucleotide binding]; other site 357809003242 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809003243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809003244 S-adenosylmethionine binding site [chemical binding]; other site 357809003245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809003246 DNA-binding site [nucleotide binding]; DNA binding site 357809003247 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809003248 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809003249 dimerization interface [polypeptide binding]; other site 357809003250 ligand binding site [chemical binding]; other site 357809003251 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809003252 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809003253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003254 dimer interface [polypeptide binding]; other site 357809003255 conserved gate region; other site 357809003256 putative PBP binding loops; other site 357809003257 ABC-ATPase subunit interface; other site 357809003258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809003259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003260 dimer interface [polypeptide binding]; other site 357809003261 conserved gate region; other site 357809003262 putative PBP binding loops; other site 357809003263 ABC-ATPase subunit interface; other site 357809003264 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 357809003265 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 357809003266 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 357809003267 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 357809003268 active site 357809003269 catalytic triad [active] 357809003270 oxyanion hole [active] 357809003271 beta-phosphoglucomutase; Region: bPGM; TIGR01990 357809003272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809003273 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 357809003274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809003275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809003276 active site 357809003277 phosphorylation site [posttranslational modification] 357809003278 intermolecular recognition site; other site 357809003279 dimerization interface [polypeptide binding]; other site 357809003280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809003281 DNA binding site [nucleotide binding] 357809003282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809003283 HAMP domain; Region: HAMP; pfam00672 357809003284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809003285 dimer interface [polypeptide binding]; other site 357809003286 phosphorylation site [posttranslational modification] 357809003287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809003288 ATP binding site [chemical binding]; other site 357809003289 Mg2+ binding site [ion binding]; other site 357809003290 G-X-G motif; other site 357809003291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809003292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809003293 Walker A/P-loop; other site 357809003294 ATP binding site [chemical binding]; other site 357809003295 Q-loop/lid; other site 357809003296 ABC transporter signature motif; other site 357809003297 Walker B; other site 357809003298 D-loop; other site 357809003299 H-loop/switch region; other site 357809003300 FtsX-like permease family; Region: FtsX; pfam02687 357809003301 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809003302 FtsX-like permease family; Region: FtsX; pfam02687 357809003303 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 357809003304 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 357809003305 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 357809003306 putative active site [active] 357809003307 metal binding site [ion binding]; metal-binding site 357809003308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809003309 Coenzyme A binding pocket [chemical binding]; other site 357809003310 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 357809003311 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357809003312 substrate binding site [chemical binding]; other site 357809003313 ATP binding site [chemical binding]; other site 357809003314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 357809003315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809003316 Coenzyme A binding pocket [chemical binding]; other site 357809003317 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 357809003318 nudix motif; other site 357809003319 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809003320 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809003321 dimer interface [polypeptide binding]; other site 357809003322 putative CheW interface [polypeptide binding]; other site 357809003323 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 357809003324 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809003325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003326 Walker A/P-loop; other site 357809003327 ATP binding site [chemical binding]; other site 357809003328 ABC transporter signature motif; other site 357809003329 Walker B; other site 357809003330 D-loop; other site 357809003331 H-loop/switch region; other site 357809003332 ABC transporter; Region: ABC_tran_2; pfam12848 357809003333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809003334 Uncharacterized conserved protein [Function unknown]; Region: COG1284 357809003335 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809003336 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809003337 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 357809003338 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 357809003339 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357809003340 active site 357809003341 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 357809003342 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357809003343 active site 357809003344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809003345 FeS/SAM binding site; other site 357809003346 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 357809003347 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357809003348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809003349 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809003350 DNA binding residues [nucleotide binding] 357809003351 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 357809003352 Phage lysis protein, holin; Region: Phage_holin; pfam04688 357809003353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809003354 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809003355 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357809003356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809003357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357809003358 active site 357809003359 catalytic tetrad [active] 357809003360 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 357809003361 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809003362 active site 357809003363 catalytic tetrad [active] 357809003364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809003365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809003366 metal binding site [ion binding]; metal-binding site 357809003367 active site 357809003368 I-site; other site 357809003369 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357809003370 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 357809003371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357809003372 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809003373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809003374 dimer interface [polypeptide binding]; other site 357809003375 putative CheW interface [polypeptide binding]; other site 357809003376 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 357809003377 active site 357809003378 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809003379 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809003380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003381 Walker A/P-loop; other site 357809003382 ATP binding site [chemical binding]; other site 357809003383 Q-loop/lid; other site 357809003384 ABC transporter signature motif; other site 357809003385 Walker B; other site 357809003386 D-loop; other site 357809003387 H-loop/switch region; other site 357809003388 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 357809003389 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809003390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003391 Walker A/P-loop; other site 357809003392 ATP binding site [chemical binding]; other site 357809003393 Q-loop/lid; other site 357809003394 ABC transporter signature motif; other site 357809003395 Walker B; other site 357809003396 D-loop; other site 357809003397 H-loop/switch region; other site 357809003398 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 357809003399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003400 Walker A/P-loop; other site 357809003401 ATP binding site [chemical binding]; other site 357809003402 Q-loop/lid; other site 357809003403 ABC transporter signature motif; other site 357809003404 Walker B; other site 357809003405 D-loop; other site 357809003406 H-loop/switch region; other site 357809003407 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 357809003408 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 357809003409 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 357809003410 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809003411 DNA binding site [nucleotide binding] 357809003412 domain linker motif; other site 357809003413 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 357809003414 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357809003415 ligand binding site [chemical binding]; other site 357809003416 mannonate dehydratase; Provisional; Region: PRK03906 357809003417 mannonate dehydratase; Region: uxuA; TIGR00695 357809003418 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 357809003419 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 357809003420 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 357809003421 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 357809003422 phosphodiesterase YaeI; Provisional; Region: PRK11340 357809003423 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 357809003424 putative active site [active] 357809003425 putative metal binding site [ion binding]; other site 357809003426 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 357809003427 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809003428 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809003429 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 357809003430 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357809003431 EamA-like transporter family; Region: EamA; pfam00892 357809003432 Uncharacterized conserved protein [Function unknown]; Region: COG1284 357809003433 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809003434 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809003435 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 357809003436 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 357809003437 putative metal binding site [ion binding]; other site 357809003438 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 357809003439 Cellulose binding domain; Region: CBM_3; cl03026 357809003440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809003441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003442 dimer interface [polypeptide binding]; other site 357809003443 conserved gate region; other site 357809003444 putative PBP binding loops; other site 357809003445 ABC-ATPase subunit interface; other site 357809003446 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809003447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003448 dimer interface [polypeptide binding]; other site 357809003449 conserved gate region; other site 357809003450 putative PBP binding loops; other site 357809003451 ABC-ATPase subunit interface; other site 357809003452 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809003453 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809003454 DNA binding site [nucleotide binding] 357809003455 domain linker motif; other site 357809003456 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809003457 ligand binding site [chemical binding]; other site 357809003458 dimerization interface [polypeptide binding]; other site 357809003459 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 357809003460 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 357809003461 Peptidase family U32; Region: Peptidase_U32; pfam01136 357809003462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809003463 binding surface 357809003464 TPR motif; other site 357809003465 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357809003466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809003467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809003468 metal binding site [ion binding]; metal-binding site 357809003469 active site 357809003470 I-site; other site 357809003471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809003472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809003473 metal binding site [ion binding]; metal-binding site 357809003474 active site 357809003475 I-site; other site 357809003476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003477 Walker A/P-loop; other site 357809003478 ATP binding site [chemical binding]; other site 357809003479 ABC transporter; Region: ABC_tran; pfam00005 357809003480 Q-loop/lid; other site 357809003481 ABC transporter signature motif; other site 357809003482 Walker B; other site 357809003483 D-loop; other site 357809003484 H-loop/switch region; other site 357809003485 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 357809003486 Zn binding site [ion binding]; other site 357809003487 Protein of unknown function (DUF419); Region: DUF419; pfam04237 357809003488 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357809003489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809003490 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 357809003491 DNA binding residues [nucleotide binding] 357809003492 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 357809003493 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809003494 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809003495 catalytic residue [active] 357809003496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809003497 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809003498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003499 dimer interface [polypeptide binding]; other site 357809003500 conserved gate region; other site 357809003501 putative PBP binding loops; other site 357809003502 ABC-ATPase subunit interface; other site 357809003503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809003504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003505 dimer interface [polypeptide binding]; other site 357809003506 conserved gate region; other site 357809003507 putative PBP binding loops; other site 357809003508 ABC-ATPase subunit interface; other site 357809003509 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 357809003510 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 357809003511 HflX GTPase family; Region: HflX; cd01878 357809003512 G1 box; other site 357809003513 GTP/Mg2+ binding site [chemical binding]; other site 357809003514 Switch I region; other site 357809003515 G2 box; other site 357809003516 G3 box; other site 357809003517 Switch II region; other site 357809003518 G4 box; other site 357809003519 G5 box; other site 357809003520 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357809003521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809003522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809003523 DNA binding residues [nucleotide binding] 357809003524 Putative zinc-finger; Region: zf-HC2; pfam13490 357809003525 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 357809003526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357809003527 Catalytic site [active] 357809003528 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 357809003529 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 357809003530 Walker A/P-loop; other site 357809003531 ATP binding site [chemical binding]; other site 357809003532 Q-loop/lid; other site 357809003533 ABC transporter signature motif; other site 357809003534 Walker B; other site 357809003535 D-loop; other site 357809003536 H-loop/switch region; other site 357809003537 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 357809003538 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 357809003539 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357809003540 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 357809003541 iron-sulfur cluster [ion binding]; other site 357809003542 [2Fe-2S] cluster binding site [ion binding]; other site 357809003543 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 357809003544 putative active site [active] 357809003545 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 357809003546 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 357809003547 putative oligomer interface [polypeptide binding]; other site 357809003548 putative active site [active] 357809003549 metal binding site [ion binding]; metal-binding site 357809003550 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 357809003551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809003552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809003553 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809003554 dimerization interface [polypeptide binding]; other site 357809003555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809003556 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809003557 Right handed beta helix region; Region: Beta_helix; pfam13229 357809003558 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 357809003559 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 357809003560 putative dimer interface [polypeptide binding]; other site 357809003561 active site pocket [active] 357809003562 putative cataytic base [active] 357809003563 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 357809003564 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 357809003565 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357809003566 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 357809003567 catalytic core [active] 357809003568 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 357809003569 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 357809003570 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809003571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809003572 homodimer interface [polypeptide binding]; other site 357809003573 catalytic residue [active] 357809003574 cobyric acid synthase; Provisional; Region: PRK00784 357809003575 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809003576 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809003577 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 357809003578 catalytic triad [active] 357809003579 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 357809003580 Predicted flavoprotein [General function prediction only]; Region: COG0431 357809003581 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357809003582 seryl-tRNA synthetase; Provisional; Region: PRK05431 357809003583 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 357809003584 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357809003585 motif 1; other site 357809003586 dimer interface [polypeptide binding]; other site 357809003587 active site 357809003588 motif 2; other site 357809003589 motif 3; other site 357809003590 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809003591 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 357809003592 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 357809003593 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 357809003594 NAD binding site [chemical binding]; other site 357809003595 dimer interface [polypeptide binding]; other site 357809003596 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357809003597 substrate binding site [chemical binding]; other site 357809003598 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809003599 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809003600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003601 dimer interface [polypeptide binding]; other site 357809003602 conserved gate region; other site 357809003603 ABC-ATPase subunit interface; other site 357809003604 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809003605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003606 dimer interface [polypeptide binding]; other site 357809003607 ABC-ATPase subunit interface; other site 357809003608 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 357809003609 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 357809003610 putative active site [active] 357809003611 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357809003612 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357809003613 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357809003614 putative active site [active] 357809003615 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 357809003616 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 357809003617 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 357809003618 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 357809003619 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 357809003620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809003621 Coenzyme A binding pocket [chemical binding]; other site 357809003622 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 357809003623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003624 Walker A/P-loop; other site 357809003625 ATP binding site [chemical binding]; other site 357809003626 Q-loop/lid; other site 357809003627 ABC transporter signature motif; other site 357809003628 Walker B; other site 357809003629 D-loop; other site 357809003630 H-loop/switch region; other site 357809003631 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 357809003632 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 357809003633 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 357809003634 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357809003635 putative ligand binding site [chemical binding]; other site 357809003636 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809003637 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809003638 TM-ABC transporter signature motif; other site 357809003639 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357809003640 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809003641 Walker A/P-loop; other site 357809003642 ATP binding site [chemical binding]; other site 357809003643 Q-loop/lid; other site 357809003644 ABC transporter signature motif; other site 357809003645 Walker B; other site 357809003646 D-loop; other site 357809003647 H-loop/switch region; other site 357809003648 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809003649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357809003650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809003651 dimerization interface [polypeptide binding]; other site 357809003652 PAS domain S-box; Region: sensory_box; TIGR00229 357809003653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357809003654 putative active site [active] 357809003655 heme pocket [chemical binding]; other site 357809003656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809003657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809003658 metal binding site [ion binding]; metal-binding site 357809003659 active site 357809003660 I-site; other site 357809003661 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357809003662 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 357809003663 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 357809003664 putative NADH binding site [chemical binding]; other site 357809003665 putative active site [active] 357809003666 nudix motif; other site 357809003667 putative metal binding site [ion binding]; other site 357809003668 GTPase RsgA; Reviewed; Region: PRK01889 357809003669 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357809003670 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 357809003671 GTPase/Zn-binding domain interface [polypeptide binding]; other site 357809003672 GTP/Mg2+ binding site [chemical binding]; other site 357809003673 G4 box; other site 357809003674 G5 box; other site 357809003675 G1 box; other site 357809003676 Switch I region; other site 357809003677 G2 box; other site 357809003678 G3 box; other site 357809003679 Switch II region; other site 357809003680 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 357809003681 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 357809003682 putative dimer interface [polypeptide binding]; other site 357809003683 putative anticodon binding site; other site 357809003684 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357809003685 motif 1; other site 357809003686 dimer interface [polypeptide binding]; other site 357809003687 active site 357809003688 motif 2; other site 357809003689 motif 3; other site 357809003690 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 357809003691 active site 357809003692 catalytic triad [active] 357809003693 oxyanion hole [active] 357809003694 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 357809003695 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357809003696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 357809003697 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 357809003698 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 357809003699 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357809003700 putative N- and C-terminal domain interface [polypeptide binding]; other site 357809003701 putative active site [active] 357809003702 MgATP binding site [chemical binding]; other site 357809003703 catalytic site [active] 357809003704 metal binding site [ion binding]; metal-binding site 357809003705 putative carbohydrate binding site [chemical binding]; other site 357809003706 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 357809003707 N- and C-terminal domain interface [polypeptide binding]; other site 357809003708 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 357809003709 active site 357809003710 putative catalytic site [active] 357809003711 metal binding site [ion binding]; metal-binding site 357809003712 ATP binding site [chemical binding]; other site 357809003713 carbohydrate binding site [chemical binding]; other site 357809003714 L-rhamnose isomerase; Provisional; Region: PRK01076 357809003715 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 357809003716 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809003717 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809003718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809003719 Domain of unknown function (DUF718); Region: DUF718; cl01281 357809003720 Domain of unknown function DUF77; Region: DUF77; pfam01910 357809003721 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357809003722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809003723 putative PBP binding loops; other site 357809003724 dimer interface [polypeptide binding]; other site 357809003725 ABC-ATPase subunit interface; other site 357809003726 NMT1/THI5 like; Region: NMT1; pfam09084 357809003727 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357809003728 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357809003729 Walker A/P-loop; other site 357809003730 ATP binding site [chemical binding]; other site 357809003731 Q-loop/lid; other site 357809003732 ABC transporter signature motif; other site 357809003733 Walker B; other site 357809003734 D-loop; other site 357809003735 H-loop/switch region; other site 357809003736 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 357809003737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809003738 ATP binding site [chemical binding]; other site 357809003739 putative Mg++ binding site [ion binding]; other site 357809003740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809003741 nucleotide binding region [chemical binding]; other site 357809003742 ATP-binding site [chemical binding]; other site 357809003743 RQC domain; Region: RQC; pfam09382 357809003744 HRDC domain; Region: HRDC; pfam00570 357809003745 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 357809003746 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 357809003747 generic binding surface II; other site 357809003748 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809003749 active site 357809003750 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 357809003751 generic binding surface I; other site 357809003752 generic binding surface II; other site 357809003753 YibE/F-like protein; Region: YibE_F; pfam07907 357809003754 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 357809003755 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809003756 active site 357809003757 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 357809003758 generic binding surface II; other site 357809003759 generic binding surface I; other site 357809003760 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 357809003761 generic binding surface II; other site 357809003762 generic binding surface I; other site 357809003763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809003764 Coenzyme A binding pocket [chemical binding]; other site 357809003765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003766 Walker A/P-loop; other site 357809003767 ATP binding site [chemical binding]; other site 357809003768 Q-loop/lid; other site 357809003769 ABC transporter signature motif; other site 357809003770 Walker B; other site 357809003771 D-loop; other site 357809003772 H-loop/switch region; other site 357809003773 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357809003774 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357809003775 DNA-binding site [nucleotide binding]; DNA binding site 357809003776 RNA-binding motif; other site 357809003777 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 357809003778 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 357809003779 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 357809003780 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 357809003781 NADP binding site [chemical binding]; other site 357809003782 homodimer interface [polypeptide binding]; other site 357809003783 active site 357809003784 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809003785 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357809003786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809003787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809003788 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 357809003789 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 357809003790 NAD binding site [chemical binding]; other site 357809003791 homodimer interface [polypeptide binding]; other site 357809003792 active site 357809003793 substrate binding site [chemical binding]; other site 357809003794 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 357809003795 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 357809003796 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 357809003797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809003798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809003799 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 357809003800 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 357809003801 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357809003802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809003803 dimerization interface [polypeptide binding]; other site 357809003804 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809003805 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809003806 dimer interface [polypeptide binding]; other site 357809003807 putative CheW interface [polypeptide binding]; other site 357809003808 Pyruvate formate lyase; Region: PFL; pfam02901 357809003809 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 357809003810 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 357809003811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809003812 FeS/SAM binding site; other site 357809003813 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 357809003814 putative hexamer interface [polypeptide binding]; other site 357809003815 putative hexagonal pore; other site 357809003816 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 357809003817 intersubunit interface [polypeptide binding]; other site 357809003818 active site 357809003819 Zn2+ binding site [ion binding]; other site 357809003820 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 357809003821 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 357809003822 putative catalytic cysteine [active] 357809003823 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 357809003824 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357809003825 catalytic Zn binding site [ion binding]; other site 357809003826 tetramer interface [polypeptide binding]; other site 357809003827 structural Zn binding site [ion binding]; other site 357809003828 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809003829 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 357809003830 Hexamer interface [polypeptide binding]; other site 357809003831 Hexagonal pore residue; other site 357809003832 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809003833 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 357809003834 Hexamer interface [polypeptide binding]; other site 357809003835 Hexagonal pore residue; other site 357809003836 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809003837 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 357809003838 Hexamer interface [polypeptide binding]; other site 357809003839 Hexagonal pore residue; other site 357809003840 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 357809003841 Propanediol utilisation protein PduL; Region: PduL; pfam06130 357809003842 Propanediol utilisation protein PduL; Region: PduL; pfam06130 357809003843 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 357809003844 Hexamer/Pentamer interface [polypeptide binding]; other site 357809003845 central pore; other site 357809003846 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 357809003847 SLBB domain; Region: SLBB; pfam10531 357809003848 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 357809003849 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 357809003850 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 357809003851 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 357809003852 putative hexamer interface [polypeptide binding]; other site 357809003853 putative hexagonal pore; other site 357809003854 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 357809003855 putative hexamer interface [polypeptide binding]; other site 357809003856 putative hexagonal pore; other site 357809003857 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 357809003858 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 357809003859 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 357809003860 RDD family; Region: RDD; pfam06271 357809003861 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357809003862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809003863 binding surface 357809003864 TPR motif; other site 357809003865 TPR repeat; Region: TPR_11; pfam13414 357809003866 TPR repeat; Region: TPR_11; pfam13414 357809003867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809003868 binding surface 357809003869 TPR motif; other site 357809003870 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357809003871 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 357809003872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809003873 binding surface 357809003874 TPR motif; other site 357809003875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809003876 binding surface 357809003877 TPR motif; other site 357809003878 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 357809003879 Catalytic dyad [active] 357809003880 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 357809003881 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 357809003882 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 357809003883 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 357809003884 FeoA domain; Region: FeoA; pfam04023 357809003885 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 357809003886 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 357809003887 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 357809003888 G1 box; other site 357809003889 GTP/Mg2+ binding site [chemical binding]; other site 357809003890 Switch I region; other site 357809003891 G2 box; other site 357809003892 G3 box; other site 357809003893 Switch II region; other site 357809003894 G4 box; other site 357809003895 G5 box; other site 357809003896 Nucleoside recognition; Region: Gate; pfam07670 357809003897 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 357809003898 Nucleoside recognition; Region: Gate; pfam07670 357809003899 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 357809003900 putative DNA binding helix; other site 357809003901 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 357809003902 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 357809003903 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809003904 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 357809003905 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 357809003906 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 357809003907 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 357809003908 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357809003909 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 357809003910 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 357809003911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809003912 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 357809003913 putative ADP-binding pocket [chemical binding]; other site 357809003914 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 357809003915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809003916 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 357809003917 putative ADP-binding pocket [chemical binding]; other site 357809003918 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 357809003919 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 357809003920 O-Antigen ligase; Region: Wzy_C; pfam04932 357809003921 colanic acid exporter; Provisional; Region: PRK10459 357809003922 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 357809003923 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 357809003924 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809003925 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 357809003926 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 357809003927 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 357809003928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357809003929 putative NAD(P) binding site [chemical binding]; other site 357809003930 active site 357809003931 putative substrate binding site [chemical binding]; other site 357809003932 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 357809003933 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 357809003934 Chain length determinant protein; Region: Wzz; cl15801 357809003935 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 357809003936 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 357809003937 Nucleotide binding site [chemical binding]; other site 357809003938 DTAP/Switch II; other site 357809003939 Switch I; other site 357809003940 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809003941 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 357809003942 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 357809003943 active site 357809003944 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809003945 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 357809003946 active site 357809003947 MutS domain III; Region: MutS_III; pfam05192 357809003948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003949 Walker A/P-loop; other site 357809003950 ATP binding site [chemical binding]; other site 357809003951 Q-loop/lid; other site 357809003952 ABC transporter signature motif; other site 357809003953 Walker B; other site 357809003954 D-loop; other site 357809003955 H-loop/switch region; other site 357809003956 xylose isomerase; Provisional; Region: PRK05474 357809003957 xylose isomerase; Region: xylose_isom_A; TIGR02630 357809003958 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809003959 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 357809003960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357809003961 metal ion-dependent adhesion site (MIDAS); other site 357809003962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809003963 AAA domain; Region: AAA_22; pfam13401 357809003964 Walker A motif; other site 357809003965 ATP binding site [chemical binding]; other site 357809003966 Walker B motif; other site 357809003967 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357809003968 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809003969 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809003970 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357809003971 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809003972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809003973 Walker A/P-loop; other site 357809003974 ATP binding site [chemical binding]; other site 357809003975 Q-loop/lid; other site 357809003976 ABC transporter signature motif; other site 357809003977 Walker B; other site 357809003978 D-loop; other site 357809003979 H-loop/switch region; other site 357809003980 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 357809003981 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 357809003982 cystathionine beta-lyase; Provisional; Region: PRK07671 357809003983 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357809003984 homodimer interface [polypeptide binding]; other site 357809003985 substrate-cofactor binding pocket; other site 357809003986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809003987 catalytic residue [active] 357809003988 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 357809003989 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 357809003990 dimer interface [polypeptide binding]; other site 357809003991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809003992 catalytic residue [active] 357809003993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809003994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809003995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809003996 dimerization interface [polypeptide binding]; other site 357809003997 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 357809003998 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 357809003999 Walker A/P-loop; other site 357809004000 ATP binding site [chemical binding]; other site 357809004001 Q-loop/lid; other site 357809004002 ABC transporter signature motif; other site 357809004003 Walker B; other site 357809004004 D-loop; other site 357809004005 H-loop/switch region; other site 357809004006 NIL domain; Region: NIL; pfam09383 357809004007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004008 dimer interface [polypeptide binding]; other site 357809004009 conserved gate region; other site 357809004010 ABC-ATPase subunit interface; other site 357809004011 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 357809004012 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357809004013 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 357809004014 NAD binding site [chemical binding]; other site 357809004015 dimer interface [polypeptide binding]; other site 357809004016 substrate binding site [chemical binding]; other site 357809004017 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 357809004018 FAD binding domain; Region: FAD_binding_4; pfam01565 357809004019 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 357809004020 hypothetical protein; Provisional; Region: PRK08912 357809004021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809004022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809004023 homodimer interface [polypeptide binding]; other site 357809004024 catalytic residue [active] 357809004025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 357809004026 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809004027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809004028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809004029 Walker A/P-loop; other site 357809004030 ATP binding site [chemical binding]; other site 357809004031 Q-loop/lid; other site 357809004032 ABC transporter signature motif; other site 357809004033 Walker B; other site 357809004034 D-loop; other site 357809004035 H-loop/switch region; other site 357809004036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809004037 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809004038 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809004039 Walker A/P-loop; other site 357809004040 ATP binding site [chemical binding]; other site 357809004041 Q-loop/lid; other site 357809004042 ABC transporter signature motif; other site 357809004043 Walker B; other site 357809004044 D-loop; other site 357809004045 H-loop/switch region; other site 357809004046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357809004047 Histidine kinase; Region: HisKA_3; pfam07730 357809004048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809004049 ATP binding site [chemical binding]; other site 357809004050 Mg2+ binding site [ion binding]; other site 357809004051 G-X-G motif; other site 357809004052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357809004053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809004054 active site 357809004055 phosphorylation site [posttranslational modification] 357809004056 intermolecular recognition site; other site 357809004057 dimerization interface [polypeptide binding]; other site 357809004058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357809004059 DNA binding residues [nucleotide binding] 357809004060 dimerization interface [polypeptide binding]; other site 357809004061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809004062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809004063 active site 357809004064 phosphorylation site [posttranslational modification] 357809004065 intermolecular recognition site; other site 357809004066 dimerization interface [polypeptide binding]; other site 357809004067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809004068 DNA binding site [nucleotide binding] 357809004069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809004070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809004071 dimer interface [polypeptide binding]; other site 357809004072 phosphorylation site [posttranslational modification] 357809004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809004074 ATP binding site [chemical binding]; other site 357809004075 Mg2+ binding site [ion binding]; other site 357809004076 G-X-G motif; other site 357809004077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809004078 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809004079 Walker A/P-loop; other site 357809004080 ATP binding site [chemical binding]; other site 357809004081 Q-loop/lid; other site 357809004082 ABC transporter signature motif; other site 357809004083 Walker B; other site 357809004084 D-loop; other site 357809004085 H-loop/switch region; other site 357809004086 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809004087 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809004088 FtsX-like permease family; Region: FtsX; pfam02687 357809004089 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 357809004090 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 357809004091 active site 357809004092 metal binding site [ion binding]; metal-binding site 357809004093 DNA binding site [nucleotide binding] 357809004094 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 357809004095 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 357809004096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809004097 Walker A/P-loop; other site 357809004098 ATP binding site [chemical binding]; other site 357809004099 Q-loop/lid; other site 357809004100 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 357809004101 Q-loop/lid; other site 357809004102 ABC transporter signature motif; other site 357809004103 Walker B; other site 357809004104 D-loop; other site 357809004105 H-loop/switch region; other site 357809004106 Phosphotransferase enzyme family; Region: APH; pfam01636 357809004107 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 357809004108 active site 357809004109 substrate binding site [chemical binding]; other site 357809004110 ATP binding site [chemical binding]; other site 357809004111 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 357809004112 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 357809004113 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 357809004114 NAD binding site [chemical binding]; other site 357809004115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357809004116 catalytic core [active] 357809004117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809004118 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 357809004119 active site 357809004120 motif I; other site 357809004121 motif II; other site 357809004122 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 357809004123 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809004124 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 357809004125 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357809004126 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809004127 active site 357809004128 metal binding site [ion binding]; metal-binding site 357809004129 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 357809004130 active site 357809004131 catalytic triad [active] 357809004132 oxyanion hole [active] 357809004133 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 357809004134 active site 357809004135 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 357809004136 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357809004137 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 357809004138 putative ligand binding site [chemical binding]; other site 357809004139 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809004140 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357809004141 TM-ABC transporter signature motif; other site 357809004142 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357809004143 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357809004144 TM-ABC transporter signature motif; other site 357809004145 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357809004146 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357809004147 Walker A/P-loop; other site 357809004148 ATP binding site [chemical binding]; other site 357809004149 Q-loop/lid; other site 357809004150 ABC transporter signature motif; other site 357809004151 Walker B; other site 357809004152 D-loop; other site 357809004153 H-loop/switch region; other site 357809004154 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357809004155 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357809004156 Walker A/P-loop; other site 357809004157 ATP binding site [chemical binding]; other site 357809004158 Q-loop/lid; other site 357809004159 ABC transporter signature motif; other site 357809004160 Walker B; other site 357809004161 D-loop; other site 357809004162 H-loop/switch region; other site 357809004163 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 357809004164 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 357809004165 DAK2 domain; Region: Dak2; pfam02734 357809004166 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 357809004167 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 357809004168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357809004169 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 357809004170 DNA-binding interface [nucleotide binding]; DNA binding site 357809004171 Predicted transcriptional regulators [Transcription]; Region: COG1695 357809004172 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357809004173 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 357809004174 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 357809004175 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357809004176 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 357809004177 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 357809004178 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 357809004179 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357809004180 active site 357809004181 HIGH motif; other site 357809004182 nucleotide binding site [chemical binding]; other site 357809004183 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 357809004184 KMSK motif region; other site 357809004185 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 357809004186 tRNA binding surface [nucleotide binding]; other site 357809004187 anticodon binding site; other site 357809004188 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 357809004189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809004190 Walker A motif; other site 357809004191 ATP binding site [chemical binding]; other site 357809004192 Walker B motif; other site 357809004193 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 357809004194 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 357809004195 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 357809004196 Predicted transcriptional regulators [Transcription]; Region: COG1725 357809004197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809004198 DNA-binding site [nucleotide binding]; DNA binding site 357809004199 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357809004200 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809004201 Walker A/P-loop; other site 357809004202 ATP binding site [chemical binding]; other site 357809004203 Q-loop/lid; other site 357809004204 ABC transporter signature motif; other site 357809004205 Walker B; other site 357809004206 D-loop; other site 357809004207 H-loop/switch region; other site 357809004208 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 357809004209 Uncharacterized conserved protein [Function unknown]; Region: COG4198 357809004210 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 357809004211 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 357809004212 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 357809004213 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 357809004214 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 357809004215 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809004216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809004217 active site 357809004218 phosphorylation site [posttranslational modification] 357809004219 intermolecular recognition site; other site 357809004220 dimerization interface [polypeptide binding]; other site 357809004221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809004222 DNA binding site [nucleotide binding] 357809004223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809004224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809004225 dimer interface [polypeptide binding]; other site 357809004226 phosphorylation site [posttranslational modification] 357809004227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809004228 ATP binding site [chemical binding]; other site 357809004229 Mg2+ binding site [ion binding]; other site 357809004230 G-X-G motif; other site 357809004231 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809004232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 357809004233 Walker A/P-loop; other site 357809004234 ATP binding site [chemical binding]; other site 357809004235 Q-loop/lid; other site 357809004236 ABC transporter signature motif; other site 357809004237 Walker B; other site 357809004238 D-loop; other site 357809004239 H-loop/switch region; other site 357809004240 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809004241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809004242 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357809004243 Tubby C 2; Region: Tub_2; cl02043 357809004244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809004245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809004246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809004247 dimerization interface [polypeptide binding]; other site 357809004248 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 357809004249 putative FMN binding site [chemical binding]; other site 357809004250 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357809004251 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 357809004252 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 357809004253 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357809004254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809004255 DNA-binding site [nucleotide binding]; DNA binding site 357809004256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809004257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809004258 homodimer interface [polypeptide binding]; other site 357809004259 catalytic residue [active] 357809004260 Protein of unknown function, DUF606; Region: DUF606; pfam04657 357809004261 Protein of unknown function, DUF606; Region: DUF606; pfam04657 357809004262 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357809004263 ligand binding site [chemical binding]; other site 357809004264 flexible hinge region; other site 357809004265 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 357809004266 putative pectinesterase; Region: PLN02432; cl01911 357809004267 Pectinesterase; Region: Pectinesterase; pfam01095 357809004268 HEAT repeats; Region: HEAT_2; pfam13646 357809004269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809004270 S-adenosylmethionine binding site [chemical binding]; other site 357809004271 endonuclease IV; Provisional; Region: PRK01060 357809004272 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 357809004273 AP (apurinic/apyrimidinic) site pocket; other site 357809004274 DNA interaction; other site 357809004275 Metal-binding active site; metal-binding site 357809004276 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 357809004277 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 357809004278 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 357809004279 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357809004280 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 357809004281 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 357809004282 putative ATP binding site [chemical binding]; other site 357809004283 putative substrate interface [chemical binding]; other site 357809004284 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 357809004285 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 357809004286 putative metal binding site [ion binding]; other site 357809004287 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 357809004288 Right handed beta helix region; Region: Beta_helix; pfam13229 357809004289 CARDB; Region: CARDB; pfam07705 357809004290 CARDB; Region: CARDB; pfam07705 357809004291 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 357809004292 YhhN-like protein; Region: YhhN; pfam07947 357809004293 Protein of unknown function (DUF523); Region: DUF523; pfam04463 357809004294 Protein of unknown function DUF45; Region: DUF45; pfam01863 357809004295 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357809004296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809004297 DNA-binding site [nucleotide binding]; DNA binding site 357809004298 FCD domain; Region: FCD; pfam07729 357809004299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809004300 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809004301 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 357809004302 Ligand binding site [chemical binding]; other site 357809004303 Electron transfer flavoprotein domain; Region: ETF; pfam01012 357809004304 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 357809004305 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 357809004306 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 357809004307 FAD binding domain; Region: FAD_binding_4; pfam01565 357809004308 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 357809004309 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809004310 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809004311 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 357809004312 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 357809004313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357809004314 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 357809004315 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 357809004316 active site 357809004317 (T/H)XGH motif; other site 357809004318 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 357809004319 Nucleoside recognition; Region: Gate; pfam07670 357809004320 hypothetical protein; Provisional; Region: PRK13670 357809004321 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 357809004322 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 357809004323 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 357809004324 propionate/acetate kinase; Provisional; Region: PRK12379 357809004325 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 357809004326 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 357809004327 RNase_H superfamily; Region: RNase_H_2; pfam13482 357809004328 active site 357809004329 catalytic site [active] 357809004330 substrate binding site [chemical binding]; other site 357809004331 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 357809004332 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 357809004333 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 357809004334 putative active site [active] 357809004335 catalytic site [active] 357809004336 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 357809004337 putative active site [active] 357809004338 catalytic site [active] 357809004339 flagellar operon protein TIGR03826; Region: YvyF 357809004340 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 357809004341 RuvA N terminal domain; Region: RuvA_N; pfam01330 357809004342 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 357809004343 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 357809004344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809004345 Walker A motif; other site 357809004346 ATP binding site [chemical binding]; other site 357809004347 Walker B motif; other site 357809004348 arginine finger; other site 357809004349 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 357809004350 Cell division protein ZapA; Region: ZapA; pfam05164 357809004351 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 357809004352 Peptidase family U32; Region: Peptidase_U32; pfam01136 357809004353 Collagenase; Region: DUF3656; pfam12392 357809004354 Peptidase family U32; Region: Peptidase_U32; cl03113 357809004355 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 357809004356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357809004357 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 357809004358 active site 357809004359 Ap6A binding site [chemical binding]; other site 357809004360 nudix motif; other site 357809004361 metal binding site [ion binding]; metal-binding site 357809004362 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 357809004363 Late competence development protein ComFB; Region: ComFB; pfam10719 357809004364 Predicted membrane protein [Function unknown]; Region: COG2246 357809004365 GtrA-like protein; Region: GtrA; pfam04138 357809004366 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 357809004367 PUA domain; Region: PUA; cl00607 357809004368 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 357809004369 putative RNA binding site [nucleotide binding]; other site 357809004370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809004371 S-adenosylmethionine binding site [chemical binding]; other site 357809004372 Chorismate mutase type II; Region: CM_2; smart00830 357809004373 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 357809004374 Prephenate dehydratase; Region: PDT; pfam00800 357809004375 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 357809004376 putative L-Phe binding site [chemical binding]; other site 357809004377 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 357809004378 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357809004379 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357809004380 protein binding site [polypeptide binding]; other site 357809004381 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 357809004382 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 357809004383 Protein of unknown function (DUF970); Region: DUF970; cl17525 357809004384 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 357809004385 Acyltransferase family; Region: Acyl_transf_3; pfam01757 357809004386 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 357809004387 Part of AAA domain; Region: AAA_19; pfam13245 357809004388 Family description; Region: UvrD_C_2; pfam13538 357809004389 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 357809004390 Trp repressor protein; Region: Trp_repressor; cl17266 357809004391 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 357809004392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809004393 S-adenosylmethionine binding site [chemical binding]; other site 357809004394 Tetratricopeptide repeat; Region: TPR_1; pfam00515 357809004395 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 357809004396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809004397 binding surface 357809004398 TPR motif; other site 357809004399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809004400 binding surface 357809004401 TPR motif; other site 357809004402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809004403 binding surface 357809004404 TPR motif; other site 357809004405 TPR repeat; Region: TPR_11; pfam13414 357809004406 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 357809004407 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 357809004408 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 357809004409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809004410 dimerization interface [polypeptide binding]; other site 357809004411 putative DNA binding site [nucleotide binding]; other site 357809004412 putative Zn2+ binding site [ion binding]; other site 357809004413 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 357809004414 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809004415 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 357809004416 FtsX-like permease family; Region: FtsX; pfam02687 357809004417 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809004418 FtsX-like permease family; Region: FtsX; pfam02687 357809004419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809004420 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809004421 Walker A/P-loop; other site 357809004422 ATP binding site [chemical binding]; other site 357809004423 Q-loop/lid; other site 357809004424 ABC transporter signature motif; other site 357809004425 Walker B; other site 357809004426 D-loop; other site 357809004427 H-loop/switch region; other site 357809004428 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 357809004429 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 357809004430 RibD C-terminal domain; Region: RibD_C; cl17279 357809004431 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 357809004432 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 357809004433 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809004434 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 357809004435 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 357809004436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809004437 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 357809004438 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 357809004439 tRNA; other site 357809004440 putative tRNA binding site [nucleotide binding]; other site 357809004441 putative NADP binding site [chemical binding]; other site 357809004442 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 357809004443 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 357809004444 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 357809004445 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 357809004446 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 357809004447 domain interfaces; other site 357809004448 active site 357809004449 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 357809004450 active site 357809004451 SAM binding site [chemical binding]; other site 357809004452 homodimer interface [polypeptide binding]; other site 357809004453 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 357809004454 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 357809004455 active site 357809004456 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 357809004457 dimer interface [polypeptide binding]; other site 357809004458 active site 357809004459 Schiff base residues; other site 357809004460 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 357809004461 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357809004462 inhibitor-cofactor binding pocket; inhibition site 357809004463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809004464 catalytic residue [active] 357809004465 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 357809004466 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 357809004467 active site 357809004468 SAM binding site [chemical binding]; other site 357809004469 homodimer interface [polypeptide binding]; other site 357809004470 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 357809004471 active site 357809004472 SAM binding site [chemical binding]; other site 357809004473 homodimer interface [polypeptide binding]; other site 357809004474 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 357809004475 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 357809004476 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 357809004477 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 357809004478 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 357809004479 active site 357809004480 SAM binding site [chemical binding]; other site 357809004481 homodimer interface [polypeptide binding]; other site 357809004482 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 357809004483 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 357809004484 active site 357809004485 putative homodimer interface [polypeptide binding]; other site 357809004486 SAM binding site [chemical binding]; other site 357809004487 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 357809004488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809004489 S-adenosylmethionine binding site [chemical binding]; other site 357809004490 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 357809004491 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 357809004492 catalytic triad [active] 357809004493 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 357809004494 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 357809004495 Precorrin-8X methylmutase; Region: CbiC; pfam02570 357809004496 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 357809004497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809004498 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357809004499 Walker A/P-loop; other site 357809004500 ATP binding site [chemical binding]; other site 357809004501 Q-loop/lid; other site 357809004502 ABC transporter signature motif; other site 357809004503 Walker B; other site 357809004504 D-loop; other site 357809004505 H-loop/switch region; other site 357809004506 cobalt transport protein CbiM; Validated; Region: PRK08319 357809004507 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 357809004508 cobalt transport protein CbiN; Provisional; Region: PRK02898 357809004509 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 357809004510 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 357809004511 active site 357809004512 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 357809004513 active site 357809004514 N-terminal domain interface [polypeptide binding]; other site 357809004515 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357809004516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004517 dimer interface [polypeptide binding]; other site 357809004518 conserved gate region; other site 357809004519 putative PBP binding loops; other site 357809004520 ABC-ATPase subunit interface; other site 357809004521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809004522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004523 dimer interface [polypeptide binding]; other site 357809004524 conserved gate region; other site 357809004525 putative PBP binding loops; other site 357809004526 ABC-ATPase subunit interface; other site 357809004527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809004528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809004529 Histidine kinase; Region: His_kinase; pfam06580 357809004530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809004531 ATP binding site [chemical binding]; other site 357809004532 Mg2+ binding site [ion binding]; other site 357809004533 G-X-G motif; other site 357809004534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809004535 Response regulator receiver domain; Region: Response_reg; pfam00072 357809004536 active site 357809004537 phosphorylation site [posttranslational modification] 357809004538 intermolecular recognition site; other site 357809004539 dimerization interface [polypeptide binding]; other site 357809004540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809004541 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809004542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809004543 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357809004544 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 357809004545 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357809004546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809004547 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357809004548 Coenzyme A binding pocket [chemical binding]; other site 357809004549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357809004550 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 357809004551 dimer interface [polypeptide binding]; other site 357809004552 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 357809004553 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 357809004554 Predicted transcriptional regulators [Transcription]; Region: COG1733 357809004555 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 357809004556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809004557 H-loop/switch region; other site 357809004558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357809004559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809004560 S-adenosylmethionine binding site [chemical binding]; other site 357809004561 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 357809004562 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357809004563 DNA binding residues [nucleotide binding] 357809004564 drug binding residues [chemical binding]; other site 357809004565 dimer interface [polypeptide binding]; other site 357809004566 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 357809004567 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809004568 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 357809004569 Hexamer interface [polypeptide binding]; other site 357809004570 Putative hexagonal pore residue; other site 357809004571 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 357809004572 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357809004573 EamA-like transporter family; Region: EamA; cl17759 357809004574 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 357809004575 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809004576 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 357809004577 Hexamer interface [polypeptide binding]; other site 357809004578 Hexagonal pore residue; other site 357809004579 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809004580 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 357809004581 Hexamer interface [polypeptide binding]; other site 357809004582 Hexagonal pore residue; other site 357809004583 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 357809004584 putative catalytic cysteine [active] 357809004585 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 357809004586 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 357809004587 dimer interface [polypeptide binding]; other site 357809004588 active site 357809004589 glycine loop; other site 357809004590 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 357809004591 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809004592 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 357809004593 putative hexamer interface [polypeptide binding]; other site 357809004594 putative hexagonal pore; other site 357809004595 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 357809004596 G1 box; other site 357809004597 GTP/Mg2+ binding site [chemical binding]; other site 357809004598 G2 box; other site 357809004599 Switch I region; other site 357809004600 G3 box; other site 357809004601 Switch II region; other site 357809004602 G4 box; other site 357809004603 G5 box; other site 357809004604 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 357809004605 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 357809004606 putative active site [active] 357809004607 metal binding site [ion binding]; metal-binding site 357809004608 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 357809004609 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 357809004610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 357809004611 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 357809004612 Hexamer interface [polypeptide binding]; other site 357809004613 Hexagonal pore residue; other site 357809004614 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 357809004615 Hexamer/Pentamer interface [polypeptide binding]; other site 357809004616 central pore; other site 357809004617 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 357809004618 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809004619 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 357809004620 Hexamer interface [polypeptide binding]; other site 357809004621 Hexagonal pore residue; other site 357809004622 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 357809004623 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 357809004624 putative catalytic cysteine [active] 357809004625 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 357809004626 Propanediol utilisation protein PduL; Region: PduL; pfam06130 357809004627 Propanediol utilisation protein PduL; Region: PduL; pfam06130 357809004628 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809004629 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 357809004630 Hexamer interface [polypeptide binding]; other site 357809004631 Putative hexagonal pore residue; other site 357809004632 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 357809004633 hypothetical protein; Validated; Region: PRK06769 357809004634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809004635 active site 357809004636 motif I; other site 357809004637 motif II; other site 357809004638 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 357809004639 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 357809004640 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809004641 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809004642 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 357809004643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809004644 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809004645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 357809004646 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 357809004647 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809004648 NlpC/P60 family; Region: NLPC_P60; cl17555 357809004649 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 357809004650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809004651 FtsX-like permease family; Region: FtsX; pfam02687 357809004652 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809004653 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 357809004654 FtsX-like permease family; Region: FtsX; pfam02687 357809004655 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809004656 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809004657 Walker A/P-loop; other site 357809004658 ATP binding site [chemical binding]; other site 357809004659 Q-loop/lid; other site 357809004660 ABC transporter signature motif; other site 357809004661 Walker B; other site 357809004662 D-loop; other site 357809004663 H-loop/switch region; other site 357809004664 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357809004665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809004666 DNA-binding site [nucleotide binding]; DNA binding site 357809004667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809004668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809004669 homodimer interface [polypeptide binding]; other site 357809004670 catalytic residue [active] 357809004671 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357809004672 EamA-like transporter family; Region: EamA; pfam00892 357809004673 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 357809004674 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 357809004675 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 357809004676 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 357809004677 Walker A/P-loop; other site 357809004678 ATP binding site [chemical binding]; other site 357809004679 Q-loop/lid; other site 357809004680 ABC transporter signature motif; other site 357809004681 Walker B; other site 357809004682 D-loop; other site 357809004683 H-loop/switch region; other site 357809004684 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 357809004685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004686 dimer interface [polypeptide binding]; other site 357809004687 conserved gate region; other site 357809004688 putative PBP binding loops; other site 357809004689 ABC-ATPase subunit interface; other site 357809004690 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 357809004691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004692 dimer interface [polypeptide binding]; other site 357809004693 conserved gate region; other site 357809004694 ABC-ATPase subunit interface; other site 357809004695 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 357809004696 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357809004697 active site 357809004698 metal binding site [ion binding]; metal-binding site 357809004699 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 357809004700 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 357809004701 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 357809004702 active site 357809004703 catalytic site [active] 357809004704 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809004705 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809004706 DNA binding site [nucleotide binding] 357809004707 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357809004708 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 357809004709 Hemerythrin-like domain; Region: Hr-like; cd12108 357809004710 Fe binding site [ion binding]; other site 357809004711 Beta-lactamase; Region: Beta-lactamase; pfam00144 357809004712 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357809004713 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809004714 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 357809004715 DNA binding residues [nucleotide binding] 357809004716 drug binding residues [chemical binding]; other site 357809004717 dimer interface [polypeptide binding]; other site 357809004718 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 357809004719 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 357809004720 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 357809004721 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 357809004722 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 357809004723 putative L-serine binding site [chemical binding]; other site 357809004724 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357809004725 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 357809004726 GTPase RsgA; Reviewed; Region: PRK00098 357809004727 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357809004728 RNA binding site [nucleotide binding]; other site 357809004729 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 357809004730 GTP/Mg2+ binding site [chemical binding]; other site 357809004731 G4 box; other site 357809004732 G5 box; other site 357809004733 G1 box; other site 357809004734 Switch I region; other site 357809004735 G2 box; other site 357809004736 G3 box; other site 357809004737 Switch II region; other site 357809004738 RNHCP domain; Region: RNHCP; pfam12647 357809004739 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 357809004740 active site clefts [active] 357809004741 zinc binding site [ion binding]; other site 357809004742 dimer interface [polypeptide binding]; other site 357809004743 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 357809004744 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 357809004745 ligand binding site [chemical binding]; other site 357809004746 NAD binding site [chemical binding]; other site 357809004747 dimerization interface [polypeptide binding]; other site 357809004748 catalytic site [active] 357809004749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809004750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809004751 dimerization interface [polypeptide binding]; other site 357809004752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809004753 dimer interface [polypeptide binding]; other site 357809004754 phosphorylation site [posttranslational modification] 357809004755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809004756 ATP binding site [chemical binding]; other site 357809004757 Mg2+ binding site [ion binding]; other site 357809004758 G-X-G motif; other site 357809004759 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809004760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809004761 active site 357809004762 phosphorylation site [posttranslational modification] 357809004763 intermolecular recognition site; other site 357809004764 dimerization interface [polypeptide binding]; other site 357809004765 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809004766 DNA binding site [nucleotide binding] 357809004767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809004768 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809004769 Walker A/P-loop; other site 357809004770 ATP binding site [chemical binding]; other site 357809004771 Q-loop/lid; other site 357809004772 ABC transporter signature motif; other site 357809004773 Walker B; other site 357809004774 D-loop; other site 357809004775 H-loop/switch region; other site 357809004776 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 357809004777 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809004778 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 357809004779 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357809004780 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357809004781 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357809004782 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357809004783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809004784 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809004785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809004786 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 357809004787 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 357809004788 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357809004789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357809004790 dimerization interface [polypeptide binding]; other site 357809004791 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809004792 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809004793 dimer interface [polypeptide binding]; other site 357809004794 putative CheW interface [polypeptide binding]; other site 357809004795 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 357809004796 gating phenylalanine in ion channel; other site 357809004797 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 357809004798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809004799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809004800 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 357809004801 putative dimerization interface [polypeptide binding]; other site 357809004802 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 357809004803 putative MPT binding site; other site 357809004804 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 357809004805 trimer interface [polypeptide binding]; other site 357809004806 dimer interface [polypeptide binding]; other site 357809004807 putative active site [active] 357809004808 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 357809004809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809004810 FeS/SAM binding site; other site 357809004811 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 357809004812 MOSC domain; Region: MOSC; pfam03473 357809004813 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 357809004814 MPT binding site; other site 357809004815 trimer interface [polypeptide binding]; other site 357809004816 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357809004817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357809004818 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 357809004819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004820 dimer interface [polypeptide binding]; other site 357809004821 conserved gate region; other site 357809004822 putative PBP binding loops; other site 357809004823 ABC-ATPase subunit interface; other site 357809004824 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 357809004825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809004826 Walker A/P-loop; other site 357809004827 ATP binding site [chemical binding]; other site 357809004828 Q-loop/lid; other site 357809004829 ABC transporter signature motif; other site 357809004830 Walker B; other site 357809004831 D-loop; other site 357809004832 H-loop/switch region; other site 357809004833 XdhC Rossmann domain; Region: XdhC_C; pfam13478 357809004834 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 357809004835 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 357809004836 selenophosphate synthetase; Provisional; Region: PRK00943 357809004837 dimerization interface [polypeptide binding]; other site 357809004838 putative ATP binding site [chemical binding]; other site 357809004839 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 357809004840 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 357809004841 CPxP motif; other site 357809004842 DsrE/DsrF-like family; Region: DrsE; pfam02635 357809004843 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 357809004844 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357809004845 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809004846 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809004847 catalytic residue [active] 357809004848 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 357809004849 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 357809004850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 357809004851 YheO-like PAS domain; Region: PAS_6; pfam08348 357809004852 HTH domain; Region: HTH_22; pfam13309 357809004853 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357809004854 homotrimer interaction site [polypeptide binding]; other site 357809004855 putative active site [active] 357809004856 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 357809004857 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 357809004858 active site 357809004859 putative substrate binding pocket [chemical binding]; other site 357809004860 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 357809004861 phenylhydantoinase; Validated; Region: PRK08323 357809004862 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 357809004863 tetramer interface [polypeptide binding]; other site 357809004864 active site 357809004865 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 357809004866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357809004867 catalytic loop [active] 357809004868 iron binding site [ion binding]; other site 357809004869 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 357809004870 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357809004871 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357809004872 xanthine permease; Region: pbuX; TIGR03173 357809004873 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 357809004874 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 357809004875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809004876 catalytic residue [active] 357809004877 peptidase; Reviewed; Region: PRK13004 357809004878 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 357809004879 putative metal binding site [ion binding]; other site 357809004880 putative dimer interface [polypeptide binding]; other site 357809004881 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 357809004882 Amidohydrolase family; Region: Amidohydro_3; pfam07969 357809004883 active site 357809004884 putative substrate binding pocket [chemical binding]; other site 357809004885 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357809004886 methionine sulfoxide reductase A; Provisional; Region: PRK14054 357809004887 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 357809004888 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809004889 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 357809004890 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 357809004891 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 357809004892 nudix motif; other site 357809004893 Protein of unknown function (DUF429); Region: DUF429; pfam04250 357809004894 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 357809004895 Hemerythrin-like domain; Region: Hr-like; cd12108 357809004896 Fe binding site [ion binding]; other site 357809004897 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 357809004898 Uncharacterized conserved protein [Function unknown]; Region: COG3603 357809004899 Family description; Region: ACT_7; pfam13840 357809004900 Rhomboid family; Region: Rhomboid; cl11446 357809004901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809004902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809004903 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357809004904 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 357809004905 active site 357809004906 FMN binding site [chemical binding]; other site 357809004907 substrate binding site [chemical binding]; other site 357809004908 putative catalytic residue [active] 357809004909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357809004910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809004911 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 357809004912 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 357809004913 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 357809004914 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 357809004915 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357809004916 catalytic loop [active] 357809004917 iron binding site [ion binding]; other site 357809004918 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 357809004919 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 357809004920 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357809004921 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357809004922 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 357809004923 Ligand binding site; other site 357809004924 metal-binding site 357809004925 Cache domain; Region: Cache_1; pfam02743 357809004926 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357809004927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809004928 dimerization interface [polypeptide binding]; other site 357809004929 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809004930 dimer interface [polypeptide binding]; other site 357809004931 putative CheW interface [polypeptide binding]; other site 357809004932 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 357809004933 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 357809004934 active site 357809004935 trimer interface [polypeptide binding]; other site 357809004936 allosteric site; other site 357809004937 active site lid [active] 357809004938 hexamer (dimer of trimers) interface [polypeptide binding]; other site 357809004939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 357809004940 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 357809004941 Mor transcription activator family; Region: Mor; cl02360 357809004942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809004943 Coenzyme A binding pocket [chemical binding]; other site 357809004944 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 357809004945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809004946 Coenzyme A binding pocket [chemical binding]; other site 357809004947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809004948 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809004949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809004950 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809004951 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809004952 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809004953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004954 dimer interface [polypeptide binding]; other site 357809004955 conserved gate region; other site 357809004956 putative PBP binding loops; other site 357809004957 ABC-ATPase subunit interface; other site 357809004958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809004959 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809004960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809004961 dimer interface [polypeptide binding]; other site 357809004962 conserved gate region; other site 357809004963 putative PBP binding loops; other site 357809004964 ABC-ATPase subunit interface; other site 357809004965 Uncharacterized conserved protein [Function unknown]; Region: COG5646 357809004966 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357809004967 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 357809004968 putative catalytic site [active] 357809004969 putative metal binding site [ion binding]; other site 357809004970 putative phosphate binding site [ion binding]; other site 357809004971 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 357809004972 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 357809004973 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 357809004974 active site 357809004975 HIGH motif; other site 357809004976 KMSK motif region; other site 357809004977 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 357809004978 tRNA binding surface [nucleotide binding]; other site 357809004979 anticodon binding site; other site 357809004980 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 357809004981 nudix motif; other site 357809004982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357809004983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809004984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357809004985 Coenzyme A binding pocket [chemical binding]; other site 357809004986 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 357809004987 AP (apurinic/apyrimidinic) site pocket; other site 357809004988 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357809004989 DNA interaction; other site 357809004990 Metal-binding active site; metal-binding site 357809004991 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 357809004992 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 357809004993 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 357809004994 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 357809004995 lipoyl attachment site [posttranslational modification]; other site 357809004996 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 357809004997 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 357809004998 tetramer interface [polypeptide binding]; other site 357809004999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809005000 catalytic residue [active] 357809005001 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 357809005002 tetramer interface [polypeptide binding]; other site 357809005003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809005004 catalytic residue [active] 357809005005 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 357809005006 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 357809005007 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 357809005008 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 357809005009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809005010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809005011 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357809005012 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 357809005013 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 357809005014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809005015 nucleotide binding region [chemical binding]; other site 357809005016 ATP-binding site [chemical binding]; other site 357809005017 Protein of unknown function (DUF503); Region: DUF503; pfam04456 357809005018 Cupin domain; Region: Cupin_2; cl17218 357809005019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809005020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809005021 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809005022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005023 dimer interface [polypeptide binding]; other site 357809005024 conserved gate region; other site 357809005025 putative PBP binding loops; other site 357809005026 ABC-ATPase subunit interface; other site 357809005027 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809005028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005029 dimer interface [polypeptide binding]; other site 357809005030 conserved gate region; other site 357809005031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809005032 ABC-ATPase subunit interface; other site 357809005033 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357809005034 Protein of unknown function, DUF624; Region: DUF624; pfam04854 357809005035 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 357809005036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809005037 motif II; other site 357809005038 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 357809005039 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 357809005040 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 357809005041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809005042 non-specific DNA binding site [nucleotide binding]; other site 357809005043 salt bridge; other site 357809005044 sequence-specific DNA binding site [nucleotide binding]; other site 357809005045 Collagen binding domain; Region: Collagen_bind; pfam05737 357809005046 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 357809005047 Collagen binding domain; Region: Collagen_bind; pfam05737 357809005048 Collagen binding domain; Region: Collagen_bind; pfam05737 357809005049 Collagen binding domain; Region: Collagen_bind; pfam05737 357809005050 Cna protein B-type domain; Region: Cna_B; pfam05738 357809005051 Cna protein B-type domain; Region: Cna_B; pfam05738 357809005052 Cna protein B-type domain; Region: Cna_B; pfam05738 357809005053 Cna protein B-type domain; Region: Cna_B; pfam05738 357809005054 Cna protein B-type domain; Region: Cna_B; pfam05738 357809005055 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357809005056 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809005057 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809005058 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809005059 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809005060 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357809005061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809005062 DNA-binding site [nucleotide binding]; DNA binding site 357809005063 FCD domain; Region: FCD; pfam07729 357809005064 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809005065 4Fe-4S binding domain; Region: Fer4; pfam00037 357809005066 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 357809005067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809005068 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 357809005069 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 357809005070 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809005071 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357809005072 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809005073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809005074 motif II; other site 357809005075 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809005076 Protein of unknown function (DUF328); Region: DUF328; pfam03883 357809005077 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 357809005078 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 357809005079 catalytic triad [active] 357809005080 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 357809005081 Ferritin-like domain; Region: Ferritin; pfam00210 357809005082 ferroxidase diiron center [ion binding]; other site 357809005083 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809005084 active site 357809005085 catalytic triad [active] 357809005086 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809005087 active site 357809005088 catalytic triad [active] 357809005089 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809005090 active site 357809005091 catalytic triad [active] 357809005092 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809005093 active site 357809005094 catalytic triad [active] 357809005095 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809005096 active site 357809005097 catalytic triad [active] 357809005098 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809005099 active site 357809005100 catalytic triad [active] 357809005101 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357809005102 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357809005103 nucleotide binding site [chemical binding]; other site 357809005104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809005105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809005106 DNA binding residues [nucleotide binding] 357809005107 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 357809005108 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 357809005109 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357809005110 ligand binding site [chemical binding]; other site 357809005111 Histidine kinase; Region: His_kinase; pfam06580 357809005112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809005113 ATP binding site [chemical binding]; other site 357809005114 Mg2+ binding site [ion binding]; other site 357809005115 G-X-G motif; other site 357809005116 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 357809005117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809005118 active site 357809005119 phosphorylation site [posttranslational modification] 357809005120 intermolecular recognition site; other site 357809005121 dimerization interface [polypeptide binding]; other site 357809005122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809005123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809005124 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 357809005125 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 357809005126 putative ligand binding site [chemical binding]; other site 357809005127 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 357809005128 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 357809005129 putative ligand binding site [chemical binding]; other site 357809005130 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357809005131 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809005132 Walker A/P-loop; other site 357809005133 ATP binding site [chemical binding]; other site 357809005134 Q-loop/lid; other site 357809005135 ABC transporter signature motif; other site 357809005136 Walker B; other site 357809005137 D-loop; other site 357809005138 H-loop/switch region; other site 357809005139 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809005140 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809005141 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809005142 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809005143 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809005144 TM-ABC transporter signature motif; other site 357809005145 SEC-C motif; Region: SEC-C; pfam02810 357809005146 hypothetical protein; Provisional; Region: PRK06851 357809005147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809005148 Walker A motif; other site 357809005149 ATP binding site [chemical binding]; other site 357809005150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809005151 non-specific DNA binding site [nucleotide binding]; other site 357809005152 salt bridge; other site 357809005153 sequence-specific DNA binding site [nucleotide binding]; other site 357809005154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809005155 H+ Antiporter protein; Region: 2A0121; TIGR00900 357809005156 putative substrate translocation pore; other site 357809005157 myosin-cross-reactive antigen; Provisional; Region: PRK13977 357809005158 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809005159 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 357809005160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357809005161 binding surface 357809005162 TPR motif; other site 357809005163 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 357809005164 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357809005165 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357809005166 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 357809005167 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 357809005168 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809005169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809005170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809005171 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 357809005172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809005173 active site 357809005174 phosphorylation site [posttranslational modification] 357809005175 intermolecular recognition site; other site 357809005176 LytTr DNA-binding domain; Region: LytTR; pfam04397 357809005177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809005178 ATP binding site [chemical binding]; other site 357809005179 Mg2+ binding site [ion binding]; other site 357809005180 G-X-G motif; other site 357809005181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357809005182 PAS domain; Region: PAS_9; pfam13426 357809005183 putative active site [active] 357809005184 heme pocket [chemical binding]; other site 357809005185 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809005186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809005187 metal binding site [ion binding]; metal-binding site 357809005188 active site 357809005189 I-site; other site 357809005190 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 357809005191 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 357809005192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357809005193 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357809005194 DNA binding residues [nucleotide binding] 357809005195 dimerization interface [polypeptide binding]; other site 357809005196 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 357809005197 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 357809005198 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 357809005199 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 357809005200 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357809005201 DNA binding residues [nucleotide binding] 357809005202 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 357809005203 Uncharacterized conserved protein [Function unknown]; Region: COG1284 357809005204 Pectate lyase; Region: Pec_lyase_C; cl01593 357809005205 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809005206 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 357809005207 DNA binding residues [nucleotide binding] 357809005208 dimer interface [polypeptide binding]; other site 357809005209 Transglycosylase; Region: Transgly; pfam00912 357809005210 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 357809005211 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 357809005212 active site 357809005213 8-oxo-dGMP binding site [chemical binding]; other site 357809005214 nudix motif; other site 357809005215 metal binding site [ion binding]; metal-binding site 357809005216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809005217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809005218 active site 357809005219 phosphorylation site [posttranslational modification] 357809005220 intermolecular recognition site; other site 357809005221 dimerization interface [polypeptide binding]; other site 357809005222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809005223 DNA binding site [nucleotide binding] 357809005224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809005225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809005226 dimer interface [polypeptide binding]; other site 357809005227 phosphorylation site [posttranslational modification] 357809005228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809005229 ATP binding site [chemical binding]; other site 357809005230 Mg2+ binding site [ion binding]; other site 357809005231 G-X-G motif; other site 357809005232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809005233 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809005234 FtsX-like permease family; Region: FtsX; pfam02687 357809005235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809005236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809005237 Walker A/P-loop; other site 357809005238 ATP binding site [chemical binding]; other site 357809005239 Q-loop/lid; other site 357809005240 ABC transporter signature motif; other site 357809005241 Walker B; other site 357809005242 D-loop; other site 357809005243 H-loop/switch region; other site 357809005244 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809005245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809005246 S-adenosylmethionine binding site [chemical binding]; other site 357809005247 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 357809005248 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357809005249 NAD(P) binding site [chemical binding]; other site 357809005250 catalytic residues [active] 357809005251 Flavin Reductases; Region: FlaRed; cl00801 357809005252 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 357809005253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809005254 active site 357809005255 catalytic tetrad [active] 357809005256 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809005257 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357809005258 conserved cys residue [active] 357809005259 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 357809005260 Part of AAA domain; Region: AAA_19; pfam13245 357809005261 Family description; Region: UvrD_C_2; pfam13538 357809005262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809005263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809005264 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809005265 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809005266 Walker A/P-loop; other site 357809005267 ATP binding site [chemical binding]; other site 357809005268 Q-loop/lid; other site 357809005269 ABC transporter signature motif; other site 357809005270 Walker B; other site 357809005271 D-loop; other site 357809005272 H-loop/switch region; other site 357809005273 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809005274 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809005275 dimer interface [polypeptide binding]; other site 357809005276 putative CheW interface [polypeptide binding]; other site 357809005277 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 357809005278 Predicted membrane protein [Function unknown]; Region: COG1971 357809005279 Domain of unknown function DUF; Region: DUF204; pfam02659 357809005280 Domain of unknown function DUF; Region: DUF204; pfam02659 357809005281 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357809005282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809005283 dimerization interface [polypeptide binding]; other site 357809005284 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809005285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809005286 dimer interface [polypeptide binding]; other site 357809005287 putative CheW interface [polypeptide binding]; other site 357809005288 hypothetical protein; Provisional; Region: PRK06215 357809005289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357809005290 Phosphotransferase enzyme family; Region: APH; pfam01636 357809005291 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 357809005292 active site 357809005293 ATP binding site [chemical binding]; other site 357809005294 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 357809005295 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 357809005296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809005297 FeS/SAM binding site; other site 357809005298 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 357809005299 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 357809005300 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 357809005301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357809005302 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809005303 active site 357809005304 Predicted transcriptional regulator [Transcription]; Region: COG2378 357809005305 HTH domain; Region: HTH_11; pfam08279 357809005306 WYL domain; Region: WYL; pfam13280 357809005307 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 357809005308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809005309 Zn2+ binding site [ion binding]; other site 357809005310 Mg2+ binding site [ion binding]; other site 357809005311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809005312 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 357809005313 putative substrate translocation pore; other site 357809005314 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 357809005315 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809005316 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809005317 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 357809005318 active site 357809005319 Hemerythrin; Region: Hemerythrin; cd12107 357809005320 Fe binding site [ion binding]; other site 357809005321 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 357809005322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809005323 S-adenosylmethionine binding site [chemical binding]; other site 357809005324 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 357809005325 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 357809005326 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357809005327 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 357809005328 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 357809005329 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 357809005330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809005331 active site 357809005332 catalytic tetrad [active] 357809005333 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357809005334 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 357809005335 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357809005336 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 357809005337 active site 357809005338 FMN binding site [chemical binding]; other site 357809005339 substrate binding site [chemical binding]; other site 357809005340 putative catalytic residue [active] 357809005341 Predicted transcriptional regulators [Transcription]; Region: COG1733 357809005342 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 357809005343 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 357809005344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809005345 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357809005346 active site 357809005347 metal binding site [ion binding]; metal-binding site 357809005348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357809005349 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 357809005350 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 357809005351 Walker A/P-loop; other site 357809005352 ATP binding site [chemical binding]; other site 357809005353 Q-loop/lid; other site 357809005354 ABC transporter signature motif; other site 357809005355 Walker B; other site 357809005356 D-loop; other site 357809005357 H-loop/switch region; other site 357809005358 PBP superfamily domain; Region: PBP_like_2; cl17296 357809005359 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357809005360 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 357809005361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005362 dimer interface [polypeptide binding]; other site 357809005363 conserved gate region; other site 357809005364 putative PBP binding loops; other site 357809005365 ABC-ATPase subunit interface; other site 357809005366 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 357809005367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005368 dimer interface [polypeptide binding]; other site 357809005369 conserved gate region; other site 357809005370 putative PBP binding loops; other site 357809005371 ABC-ATPase subunit interface; other site 357809005372 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 357809005373 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 357809005374 Walker A/P-loop; other site 357809005375 ATP binding site [chemical binding]; other site 357809005376 Q-loop/lid; other site 357809005377 ABC transporter signature motif; other site 357809005378 Walker B; other site 357809005379 D-loop; other site 357809005380 H-loop/switch region; other site 357809005381 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 357809005382 PhoU domain; Region: PhoU; pfam01895 357809005383 PhoU domain; Region: PhoU; pfam01895 357809005384 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 357809005385 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 357809005386 GIY-YIG motif/motif A; other site 357809005387 active site 357809005388 catalytic site [active] 357809005389 putative DNA binding site [nucleotide binding]; other site 357809005390 metal binding site [ion binding]; metal-binding site 357809005391 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357809005392 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357809005393 catalytic residues [active] 357809005394 4Fe-4S binding domain; Region: Fer4_5; pfam12801 357809005395 4Fe-4S binding domain; Region: Fer4_5; pfam12801 357809005396 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809005397 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 357809005398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809005399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809005400 active site 357809005401 phosphorylation site [posttranslational modification] 357809005402 intermolecular recognition site; other site 357809005403 dimerization interface [polypeptide binding]; other site 357809005404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809005405 DNA binding site [nucleotide binding] 357809005406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809005407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809005408 dimerization interface [polypeptide binding]; other site 357809005409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809005410 dimer interface [polypeptide binding]; other site 357809005411 phosphorylation site [posttranslational modification] 357809005412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809005413 ATP binding site [chemical binding]; other site 357809005414 Mg2+ binding site [ion binding]; other site 357809005415 G-X-G motif; other site 357809005416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809005417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809005418 active site 357809005419 phosphorylation site [posttranslational modification] 357809005420 intermolecular recognition site; other site 357809005421 dimerization interface [polypeptide binding]; other site 357809005422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809005423 DNA binding site [nucleotide binding] 357809005424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809005425 HAMP domain; Region: HAMP; pfam00672 357809005426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809005427 dimer interface [polypeptide binding]; other site 357809005428 phosphorylation site [posttranslational modification] 357809005429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809005430 ATP binding site [chemical binding]; other site 357809005431 Mg2+ binding site [ion binding]; other site 357809005432 G-X-G motif; other site 357809005433 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809005434 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809005435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809005436 Walker A/P-loop; other site 357809005437 ATP binding site [chemical binding]; other site 357809005438 Q-loop/lid; other site 357809005439 ABC transporter signature motif; other site 357809005440 Walker B; other site 357809005441 D-loop; other site 357809005442 H-loop/switch region; other site 357809005443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809005444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809005445 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809005446 Walker A/P-loop; other site 357809005447 ATP binding site [chemical binding]; other site 357809005448 Q-loop/lid; other site 357809005449 ABC transporter signature motif; other site 357809005450 Walker B; other site 357809005451 D-loop; other site 357809005452 H-loop/switch region; other site 357809005453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809005454 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809005455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809005456 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357809005457 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 357809005458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809005459 catalytic residue [active] 357809005460 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 357809005461 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 357809005462 FAD binding pocket [chemical binding]; other site 357809005463 phosphate binding motif [ion binding]; other site 357809005464 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 357809005465 Ca binding site [ion binding]; other site 357809005466 Ca binding site (active) [ion binding]; other site 357809005467 ligand binding site [chemical binding]; other site 357809005468 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357809005469 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809005470 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 357809005471 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 357809005472 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 357809005473 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 357809005474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 357809005475 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 357809005476 putative metal binding site; other site 357809005477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357809005478 binding surface 357809005479 TPR motif; other site 357809005480 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357809005481 MarR family; Region: MarR_2; pfam12802 357809005482 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 357809005483 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 357809005484 P loop; other site 357809005485 Nucleotide binding site [chemical binding]; other site 357809005486 DTAP/Switch II; other site 357809005487 Switch I; other site 357809005488 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 357809005489 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 357809005490 P loop; other site 357809005491 Nucleotide binding site [chemical binding]; other site 357809005492 DTAP/Switch II; other site 357809005493 Switch I; other site 357809005494 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357809005495 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357809005496 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357809005497 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809005498 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809005499 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 357809005500 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 357809005501 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809005502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809005503 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 357809005504 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809005505 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 357809005506 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809005507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005508 dimer interface [polypeptide binding]; other site 357809005509 conserved gate region; other site 357809005510 ABC-ATPase subunit interface; other site 357809005511 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809005512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005513 dimer interface [polypeptide binding]; other site 357809005514 conserved gate region; other site 357809005515 ABC-ATPase subunit interface; other site 357809005516 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 357809005517 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 357809005518 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357809005519 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 357809005520 sugar binding site [chemical binding]; other site 357809005521 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 357809005522 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 357809005523 putative active site [active] 357809005524 FOG: PKD repeat [General function prediction only]; Region: COG3291 357809005525 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 357809005526 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 357809005527 sugar binding site [chemical binding]; other site 357809005528 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809005529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005530 dimer interface [polypeptide binding]; other site 357809005531 conserved gate region; other site 357809005532 ABC-ATPase subunit interface; other site 357809005533 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809005534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005535 dimer interface [polypeptide binding]; other site 357809005536 ABC-ATPase subunit interface; other site 357809005537 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809005538 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 357809005539 Domain of unknown function (DUF377); Region: DUF377; pfam04041 357809005540 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 357809005541 active site 357809005542 Uncharacterized conserved protein [Function unknown]; Region: COG3538 357809005543 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 357809005544 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 357809005545 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 357809005546 active site 357809005547 catalytic site [active] 357809005548 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 357809005549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809005550 dimerization interface [polypeptide binding]; other site 357809005551 Histidine kinase; Region: His_kinase; pfam06580 357809005552 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 357809005553 ATP binding site [chemical binding]; other site 357809005554 G-X-G motif; other site 357809005555 Response regulator receiver domain; Region: Response_reg; pfam00072 357809005556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809005557 active site 357809005558 phosphorylation site [posttranslational modification] 357809005559 intermolecular recognition site; other site 357809005560 dimerization interface [polypeptide binding]; other site 357809005561 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809005562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809005563 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809005564 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 357809005565 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809005566 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357809005567 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 357809005568 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 357809005569 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 357809005570 putative homodimer interface [polypeptide binding]; other site 357809005571 putative DNA binding site [nucleotide binding]; other site 357809005572 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 357809005573 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 357809005574 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 357809005575 active site 357809005576 DNA binding site [nucleotide binding] 357809005577 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 357809005578 DNA binding site [nucleotide binding] 357809005579 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 357809005580 nucleotide binding site [chemical binding]; other site 357809005581 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 357809005582 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 357809005583 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357809005584 NADH dehydrogenase; Region: NADHdh; cl00469 357809005585 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 357809005586 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 357809005587 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 357809005588 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 357809005589 NADH-plastoquinone oxidoreductase subunit; Provisional; Region: PRK08348 357809005590 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809005591 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 357809005592 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 357809005593 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809005594 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357809005595 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 357809005596 Acylphosphatase; Region: Acylphosphatase; pfam00708 357809005597 HypF finger; Region: zf-HYPF; pfam07503 357809005598 HypF finger; Region: zf-HYPF; pfam07503 357809005599 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 357809005600 HupF/HypC family; Region: HupF_HypC; pfam01455 357809005601 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 357809005602 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 357809005603 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 357809005604 dimerization interface [polypeptide binding]; other site 357809005605 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 357809005606 ATP binding site [chemical binding]; other site 357809005607 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357809005608 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 357809005609 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 357809005610 active site 357809005611 FMN binding site [chemical binding]; other site 357809005612 substrate binding site [chemical binding]; other site 357809005613 putative catalytic residue [active] 357809005614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809005615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809005616 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 357809005617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357809005618 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 357809005619 NAD(P) binding site [chemical binding]; other site 357809005620 active site 357809005621 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 357809005622 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 357809005623 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 357809005624 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 357809005625 DNA binding site [nucleotide binding] 357809005626 active site 357809005627 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 357809005628 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 357809005629 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 357809005630 putative active site [active] 357809005631 catalytic triad [active] 357809005632 PA domain; Region: PA; pfam02225 357809005633 PA/protease or protease-like domain interface [polypeptide binding]; other site 357809005634 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 357809005635 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 357809005636 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 357809005637 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 357809005638 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357809005639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809005640 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357809005641 active site 357809005642 catalytic tetrad [active] 357809005643 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809005644 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357809005645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809005646 catalytic residue [active] 357809005647 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809005648 MarR family; Region: MarR; pfam01047 357809005649 Putative cyclase; Region: Cyclase; pfam04199 357809005650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809005651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809005652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809005653 dimerization interface [polypeptide binding]; other site 357809005654 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 357809005655 Na2 binding site [ion binding]; other site 357809005656 putative substrate binding site 1 [chemical binding]; other site 357809005657 Na binding site 1 [ion binding]; other site 357809005658 putative substrate binding site 2 [chemical binding]; other site 357809005659 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 357809005660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809005661 motif II; other site 357809005662 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357809005663 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357809005664 ligand binding site [chemical binding]; other site 357809005665 flexible hinge region; other site 357809005666 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 357809005667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809005668 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 357809005669 DNA-binding interface [nucleotide binding]; DNA binding site 357809005670 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 357809005671 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 357809005672 Isochorismatase family; Region: Isochorismatase; pfam00857 357809005673 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 357809005674 catalytic triad [active] 357809005675 conserved cis-peptide bond; other site 357809005676 TfoX C-terminal domain; Region: TfoX_C; pfam04994 357809005677 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 357809005678 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 357809005679 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 357809005680 active site turn [active] 357809005681 phosphorylation site [posttranslational modification] 357809005682 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 357809005683 HPr interaction site; other site 357809005684 glycerol kinase (GK) interaction site [polypeptide binding]; other site 357809005685 active site 357809005686 phosphorylation site [posttranslational modification] 357809005687 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357809005688 dimerization domain swap beta strand [polypeptide binding]; other site 357809005689 regulatory protein interface [polypeptide binding]; other site 357809005690 active site 357809005691 regulatory phosphorylation site [posttranslational modification]; other site 357809005692 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 357809005693 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 357809005694 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357809005695 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357809005696 S-layer homology domain; Region: SLH; pfam00395 357809005697 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 357809005698 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 357809005699 sugar binding site [chemical binding]; other site 357809005700 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 357809005701 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 357809005702 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 357809005703 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 357809005704 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 357809005705 active site 357809005706 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 357809005707 active site 357809005708 Predicted membrane protein [Function unknown]; Region: COG2855 357809005709 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357809005710 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 357809005711 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 357809005712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809005713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809005714 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357809005715 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357809005716 active site residue [active] 357809005717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809005718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809005719 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 357809005720 putative dimerization interface [polypeptide binding]; other site 357809005721 Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373 357809005722 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 357809005723 tRNA; other site 357809005724 putative tRNA binding site [nucleotide binding]; other site 357809005725 putative NADP binding site [chemical binding]; other site 357809005726 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 357809005727 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 357809005728 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 357809005729 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 357809005730 domain interfaces; other site 357809005731 active site 357809005732 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 357809005733 active site 357809005734 SAM binding site [chemical binding]; other site 357809005735 homodimer interface [polypeptide binding]; other site 357809005736 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 357809005737 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 357809005738 active site 357809005739 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 357809005740 dimer interface [polypeptide binding]; other site 357809005741 active site 357809005742 Schiff base residues; other site 357809005743 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 357809005744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357809005745 inhibitor-cofactor binding pocket; inhibition site 357809005746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809005747 catalytic residue [active] 357809005748 Helix-turn-helix domain; Region: HTH_17; pfam12728 357809005749 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 357809005750 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 357809005751 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809005752 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 357809005753 classical (c) SDRs; Region: SDR_c; cd05233 357809005754 NAD(P) binding site [chemical binding]; other site 357809005755 active site 357809005756 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 357809005757 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809005758 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 357809005759 dinuclear metal binding motif [ion binding]; other site 357809005760 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357809005761 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 357809005762 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 357809005763 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 357809005764 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 357809005765 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 357809005766 putative active site [active] 357809005767 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 357809005768 Glyco_18 domain; Region: Glyco_18; smart00636 357809005769 active site 357809005770 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 357809005771 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 357809005772 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 357809005773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809005774 Walker A/P-loop; other site 357809005775 ATP binding site [chemical binding]; other site 357809005776 Q-loop/lid; other site 357809005777 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357809005778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809005779 AAA domain; Region: AAA_21; pfam13304 357809005780 Walker A/P-loop; other site 357809005781 ATP binding site [chemical binding]; other site 357809005782 Q-loop/lid; other site 357809005783 ABC transporter signature motif; other site 357809005784 Walker B; other site 357809005785 D-loop; other site 357809005786 H-loop/switch region; other site 357809005787 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809005788 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357809005789 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357809005790 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809005791 Helix-turn-helix domain; Region: HTH_38; pfam13936 357809005792 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 357809005793 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809005794 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357809005795 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809005796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809005797 motif II; other site 357809005798 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809005799 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 357809005800 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357809005801 conserved repeat domain; Region: B_ant_repeat; TIGR01451 357809005802 Domain of unknown function DUF11; Region: DUF11; pfam01345 357809005803 Uncharacterized conserved protein [Function unknown]; Region: COG5649 357809005804 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 357809005805 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 357809005806 5S rRNA interface [nucleotide binding]; other site 357809005807 CTC domain interface [polypeptide binding]; other site 357809005808 L16 interface [polypeptide binding]; other site 357809005809 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809005810 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809005811 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357809005812 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 357809005813 putative DNA binding site [nucleotide binding]; other site 357809005814 putative Zn2+ binding site [ion binding]; other site 357809005815 AsnC family; Region: AsnC_trans_reg; pfam01037 357809005816 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 357809005817 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 357809005818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809005819 S-adenosylmethionine binding site [chemical binding]; other site 357809005820 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 357809005821 active site 357809005822 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 357809005823 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005824 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005825 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 357809005826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005827 Leucine-rich repeats; other site 357809005828 Substrate binding site [chemical binding]; other site 357809005829 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005830 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005831 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005832 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005833 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809005834 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 357809005835 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 357809005836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809005837 Coenzyme A binding pocket [chemical binding]; other site 357809005838 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357809005839 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 357809005840 substrate binding site [chemical binding]; other site 357809005841 dimer interface [polypeptide binding]; other site 357809005842 ATP binding site [chemical binding]; other site 357809005843 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 357809005844 active site 357809005845 tetramer interface [polypeptide binding]; other site 357809005846 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 357809005847 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 357809005848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809005849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809005850 DNA binding site [nucleotide binding] 357809005851 domain linker motif; other site 357809005852 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809005853 dimerization interface [polypeptide binding]; other site 357809005854 ligand binding site [chemical binding]; other site 357809005855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809005856 Coenzyme A binding pocket [chemical binding]; other site 357809005857 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 357809005858 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 357809005859 G1 box; other site 357809005860 putative GEF interaction site [polypeptide binding]; other site 357809005861 GTP/Mg2+ binding site [chemical binding]; other site 357809005862 Switch I region; other site 357809005863 G2 box; other site 357809005864 G3 box; other site 357809005865 Switch II region; other site 357809005866 G4 box; other site 357809005867 G5 box; other site 357809005868 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357809005869 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 357809005870 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 357809005871 YacP-like NYN domain; Region: NYN_YacP; pfam05991 357809005872 Predicted transcriptional regulator [Transcription]; Region: COG1959 357809005873 Transcriptional regulator; Region: Rrf2; cl17282 357809005874 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 357809005875 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357809005876 4Fe-4S binding domain; Region: Fer4; pfam00037 357809005877 4Fe-4S binding domain; Region: Fer4; pfam00037 357809005878 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357809005879 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357809005880 membrane-bound complex binding site; other site 357809005881 hinge residues; other site 357809005882 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 357809005883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005884 dimer interface [polypeptide binding]; other site 357809005885 conserved gate region; other site 357809005886 putative PBP binding loops; other site 357809005887 ABC-ATPase subunit interface; other site 357809005888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809005889 dimer interface [polypeptide binding]; other site 357809005890 conserved gate region; other site 357809005891 ABC-ATPase subunit interface; other site 357809005892 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357809005893 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 357809005894 Walker A/P-loop; other site 357809005895 ATP binding site [chemical binding]; other site 357809005896 Q-loop/lid; other site 357809005897 ABC transporter signature motif; other site 357809005898 Walker B; other site 357809005899 D-loop; other site 357809005900 H-loop/switch region; other site 357809005901 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 357809005902 L-aspartate oxidase; Provisional; Region: PRK06175 357809005903 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 357809005904 Ferredoxin [Energy production and conversion]; Region: COG1146 357809005905 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 357809005906 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 357809005907 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 357809005908 Active Sites [active] 357809005909 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 357809005910 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 357809005911 CysD dimerization site [polypeptide binding]; other site 357809005912 G1 box; other site 357809005913 putative GEF interaction site [polypeptide binding]; other site 357809005914 GTP/Mg2+ binding site [chemical binding]; other site 357809005915 Switch I region; other site 357809005916 G2 box; other site 357809005917 G3 box; other site 357809005918 Switch II region; other site 357809005919 G4 box; other site 357809005920 G5 box; other site 357809005921 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 357809005922 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 357809005923 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 357809005924 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809005925 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809005926 Walker A/P-loop; other site 357809005927 ATP binding site [chemical binding]; other site 357809005928 Q-loop/lid; other site 357809005929 ABC transporter signature motif; other site 357809005930 Walker B; other site 357809005931 D-loop; other site 357809005932 H-loop/switch region; other site 357809005933 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 357809005934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809005935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809005936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809005937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809005938 flavodoxin; Provisional; Region: PRK06242 357809005939 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 357809005940 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357809005941 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357809005942 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357809005943 Protein of unknown function (DUF402); Region: DUF402; cl00979 357809005944 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357809005945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809005946 dimerization interface [polypeptide binding]; other site 357809005947 putative Zn2+ binding site [ion binding]; other site 357809005948 putative DNA binding site [nucleotide binding]; other site 357809005949 Pirin-related protein [General function prediction only]; Region: COG1741 357809005950 Pirin; Region: Pirin; pfam02678 357809005951 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 357809005952 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357809005953 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 357809005954 Predicted transcriptional regulators [Transcription]; Region: COG1733 357809005955 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 357809005956 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 357809005957 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 357809005958 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357809005959 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357809005960 catalytic residues [active] 357809005961 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809005962 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 357809005963 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 357809005964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809005965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809005966 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809005967 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809005968 Walker A/P-loop; other site 357809005969 ATP binding site [chemical binding]; other site 357809005970 Q-loop/lid; other site 357809005971 ABC transporter signature motif; other site 357809005972 Walker B; other site 357809005973 D-loop; other site 357809005974 H-loop/switch region; other site 357809005975 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809005976 FtsX-like permease family; Region: FtsX; pfam02687 357809005977 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 357809005978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809005979 salt bridge; other site 357809005980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809005981 non-specific DNA binding site [nucleotide binding]; other site 357809005982 sequence-specific DNA binding site [nucleotide binding]; other site 357809005983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809005984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809005985 active site 357809005986 phosphorylation site [posttranslational modification] 357809005987 intermolecular recognition site; other site 357809005988 dimerization interface [polypeptide binding]; other site 357809005989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809005990 DNA binding site [nucleotide binding] 357809005991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809005992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809005993 dimerization interface [polypeptide binding]; other site 357809005994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809005995 dimer interface [polypeptide binding]; other site 357809005996 phosphorylation site [posttranslational modification] 357809005997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809005998 ATP binding site [chemical binding]; other site 357809005999 Mg2+ binding site [ion binding]; other site 357809006000 G-X-G motif; other site 357809006001 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 357809006002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809006003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809006004 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357809006005 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 357809006006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 357809006007 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 357809006008 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 357809006009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809006010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809006011 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357809006012 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 357809006013 active site residue [active] 357809006014 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357809006015 active site residue [active] 357809006016 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 357809006017 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 357809006018 putative active site [active] 357809006019 putative metal binding site [ion binding]; other site 357809006020 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 357809006021 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809006022 substrate binding site [chemical binding]; other site 357809006023 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 357809006024 putative metal binding site [ion binding]; other site 357809006025 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 357809006026 Ca binding site [ion binding]; other site 357809006027 ligand binding site I [chemical binding]; other site 357809006028 homodimer interface [polypeptide binding]; other site 357809006029 ligand binding site II [chemical binding]; other site 357809006030 CARDB; Region: CARDB; pfam07705 357809006031 CARDB; Region: CARDB; pfam07705 357809006032 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 357809006033 putative metal binding site [ion binding]; other site 357809006034 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 357809006035 Right handed beta helix region; Region: Beta_helix; pfam13229 357809006036 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 357809006037 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 357809006038 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 357809006039 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 357809006040 beta-phosphoglucomutase; Region: bPGM; TIGR01990 357809006041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809006042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809006043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809006044 DNA binding site [nucleotide binding] 357809006045 domain linker motif; other site 357809006046 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809006047 ligand binding site [chemical binding]; other site 357809006048 dimerization interface [polypeptide binding]; other site 357809006049 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 357809006050 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 357809006051 putative active site [active] 357809006052 putative catalytic site [active] 357809006053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809006054 dimerization interface [polypeptide binding]; other site 357809006055 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809006056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809006057 dimer interface [polypeptide binding]; other site 357809006058 putative CheW interface [polypeptide binding]; other site 357809006059 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809006060 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809006061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006062 dimer interface [polypeptide binding]; other site 357809006063 conserved gate region; other site 357809006064 putative PBP binding loops; other site 357809006065 ABC-ATPase subunit interface; other site 357809006066 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809006067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006068 dimer interface [polypeptide binding]; other site 357809006069 conserved gate region; other site 357809006070 putative PBP binding loops; other site 357809006071 ABC-ATPase subunit interface; other site 357809006072 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 357809006073 putative metal binding site [ion binding]; other site 357809006074 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 357809006075 Right handed beta helix region; Region: Beta_helix; pfam13229 357809006076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809006077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809006078 DNA binding site [nucleotide binding] 357809006079 domain linker motif; other site 357809006080 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809006081 dimerization interface [polypeptide binding]; other site 357809006082 ligand binding site [chemical binding]; other site 357809006083 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 357809006084 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 357809006085 FMN binding site [chemical binding]; other site 357809006086 active site 357809006087 catalytic residues [active] 357809006088 substrate binding site [chemical binding]; other site 357809006089 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 357809006090 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809006091 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809006092 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 357809006093 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809006094 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809006095 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 357809006096 NlpC/P60 family; Region: NLPC_P60; pfam00877 357809006097 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 357809006098 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809006099 PT repeat; Region: PT; pfam04886 357809006100 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 357809006101 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 357809006102 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 357809006103 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 357809006104 Putative cyclase; Region: Cyclase; cl00814 357809006105 Hemerythrin; Region: Hemerythrin; cd12107 357809006106 Fe binding site [ion binding]; other site 357809006107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809006108 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 357809006109 Flavodoxin domain; Region: Flavodoxin_5; cl17428 357809006110 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357809006111 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357809006112 catalytic core [active] 357809006113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809006114 Coenzyme A binding pocket [chemical binding]; other site 357809006115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809006116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809006117 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 357809006118 putative dimerization interface [polypeptide binding]; other site 357809006119 Chromate transporter; Region: Chromate_transp; pfam02417 357809006120 Chromate transporter; Region: Chromate_transp; pfam02417 357809006121 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 357809006122 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 357809006123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357809006124 Predicted membrane protein [Function unknown]; Region: COG1511 357809006125 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 357809006126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809006127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809006128 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 357809006129 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 357809006130 putative active site [active] 357809006131 catalytic triad [active] 357809006132 putative dimer interface [polypeptide binding]; other site 357809006133 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 357809006134 Helix-turn-helix domain; Region: HTH_18; pfam12833 357809006135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809006136 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809006137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006138 dimer interface [polypeptide binding]; other site 357809006139 conserved gate region; other site 357809006140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809006141 ABC-ATPase subunit interface; other site 357809006142 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809006143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006144 dimer interface [polypeptide binding]; other site 357809006145 conserved gate region; other site 357809006146 ABC-ATPase subunit interface; other site 357809006147 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809006148 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 357809006149 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 357809006150 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 357809006151 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809006152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809006153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809006154 ABC transporter; Region: ABC_tran_2; pfam12848 357809006155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006156 Walker A/P-loop; other site 357809006157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006158 H-loop/switch region; other site 357809006159 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 357809006160 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 357809006161 putative ligand binding site [chemical binding]; other site 357809006162 putative NAD binding site [chemical binding]; other site 357809006163 catalytic site [active] 357809006164 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 357809006165 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 357809006166 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 357809006167 non-heme iron binding site [ion binding]; other site 357809006168 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 357809006169 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 357809006170 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 357809006171 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357809006172 TrkA-N domain; Region: TrkA_N; pfam02254 357809006173 TrkA-C domain; Region: TrkA_C; pfam02080 357809006174 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 357809006175 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 357809006176 catalytic domain interface [polypeptide binding]; other site 357809006177 putative homodimer interface [polypeptide binding]; other site 357809006178 Holin family; Region: Phage_holin_4; pfam05105 357809006179 argininosuccinate synthase; Provisional; Region: PRK13820 357809006180 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 357809006181 ANP binding site [chemical binding]; other site 357809006182 Substrate Binding Site II [chemical binding]; other site 357809006183 Substrate Binding Site I [chemical binding]; other site 357809006184 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 357809006185 active site 357809006186 Maf-like protein; Region: Maf; pfam02545 357809006187 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 357809006188 active site 357809006189 dimer interface [polypeptide binding]; other site 357809006190 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 357809006191 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 357809006192 Ca binding site [ion binding]; other site 357809006193 active site 357809006194 catalytic site [active] 357809006195 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 357809006196 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 357809006197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809006198 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 357809006199 Melibiase; Region: Melibiase; pfam02065 357809006200 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 357809006201 beta-galactosidase; Region: BGL; TIGR03356 357809006202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357809006203 DNA-binding site [nucleotide binding]; DNA binding site 357809006204 RNA-binding motif; other site 357809006205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809006206 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357809006207 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 357809006208 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 357809006209 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357809006210 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357809006211 putative acyl-acceptor binding pocket; other site 357809006212 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 357809006213 putative sugar binding site [chemical binding]; other site 357809006214 catalytic residues [active] 357809006215 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 357809006216 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 357809006217 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357809006218 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 357809006219 heterotetramer interface [polypeptide binding]; other site 357809006220 active site pocket [active] 357809006221 cleavage site 357809006222 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 357809006223 feedback inhibition sensing region; other site 357809006224 homohexameric interface [polypeptide binding]; other site 357809006225 nucleotide binding site [chemical binding]; other site 357809006226 N-acetyl-L-glutamate binding site [chemical binding]; other site 357809006227 acetylornithine aminotransferase; Provisional; Region: PRK02627 357809006228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357809006229 inhibitor-cofactor binding pocket; inhibition site 357809006230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809006231 catalytic residue [active] 357809006232 Protein of unknown function, DUF606; Region: DUF606; pfam04657 357809006233 SLBB domain; Region: SLBB; pfam10531 357809006234 comEA protein; Region: comE; TIGR01259 357809006235 Helix-hairpin-helix motif; Region: HHH; pfam00633 357809006236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809006238 active site 357809006239 phosphorylation site [posttranslational modification] 357809006240 intermolecular recognition site; other site 357809006241 dimerization interface [polypeptide binding]; other site 357809006242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809006243 DNA binding site [nucleotide binding] 357809006244 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 357809006245 dimerization interface [polypeptide binding]; other site 357809006246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809006247 dimer interface [polypeptide binding]; other site 357809006248 phosphorylation site [posttranslational modification] 357809006249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809006250 ATP binding site [chemical binding]; other site 357809006251 Mg2+ binding site [ion binding]; other site 357809006252 G-X-G motif; other site 357809006253 Sporulation and spore germination; Region: Germane; pfam10646 357809006254 Sporulation and spore germination; Region: Germane; pfam10646 357809006255 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 357809006256 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 357809006257 Competence protein; Region: Competence; pfam03772 357809006258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809006259 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826 357809006260 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 357809006261 Cl binding site [ion binding]; other site 357809006262 oligomer interface [polypeptide binding]; other site 357809006263 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 357809006264 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 357809006265 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 357809006266 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 357809006267 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 357809006268 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 357809006269 Predicted transcriptional regulators [Transcription]; Region: COG1695 357809006270 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357809006271 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 357809006272 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 357809006273 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357809006274 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357809006275 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357809006276 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809006277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809006278 S-adenosylmethionine binding site [chemical binding]; other site 357809006279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809006280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809006281 non-specific DNA binding site [nucleotide binding]; other site 357809006282 salt bridge; other site 357809006283 sequence-specific DNA binding site [nucleotide binding]; other site 357809006284 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357809006285 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357809006286 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 357809006287 metal ion-dependent adhesion site (MIDAS); other site 357809006288 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 357809006289 Uncharacterized conserved protein [Function unknown]; Region: COG2006 357809006290 Domain of unknown function (DUF362); Region: DUF362; pfam04015 357809006291 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 357809006292 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357809006293 conserved cys residue [active] 357809006294 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 357809006295 FMN binding site [chemical binding]; other site 357809006296 dimer interface [polypeptide binding]; other site 357809006297 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809006298 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809006299 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809006300 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809006301 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809006302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809006303 dimer interface [polypeptide binding]; other site 357809006304 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809006305 putative CheW interface [polypeptide binding]; other site 357809006306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809006307 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809006308 Walker A/P-loop; other site 357809006309 ATP binding site [chemical binding]; other site 357809006310 Q-loop/lid; other site 357809006311 ABC transporter signature motif; other site 357809006312 Walker B; other site 357809006313 D-loop; other site 357809006314 H-loop/switch region; other site 357809006315 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809006316 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809006317 FtsX-like permease family; Region: FtsX; pfam02687 357809006318 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357809006319 MarR family; Region: MarR_2; pfam12802 357809006320 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357809006321 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357809006322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006323 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809006324 Walker A/P-loop; other site 357809006325 ATP binding site [chemical binding]; other site 357809006326 Q-loop/lid; other site 357809006327 ABC transporter signature motif; other site 357809006328 Walker B; other site 357809006329 D-loop; other site 357809006330 H-loop/switch region; other site 357809006331 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 357809006332 TraX protein; Region: TraX; cl05434 357809006333 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809006334 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 357809006335 Walker A/P-loop; other site 357809006336 ATP binding site [chemical binding]; other site 357809006337 Q-loop/lid; other site 357809006338 ABC transporter signature motif; other site 357809006339 Walker B; other site 357809006340 D-loop; other site 357809006341 H-loop/switch region; other site 357809006342 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 357809006343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809006344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809006345 active site 357809006346 phosphorylation site [posttranslational modification] 357809006347 intermolecular recognition site; other site 357809006348 dimerization interface [polypeptide binding]; other site 357809006349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809006350 DNA binding site [nucleotide binding] 357809006351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809006352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809006353 dimer interface [polypeptide binding]; other site 357809006354 phosphorylation site [posttranslational modification] 357809006355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809006356 ATP binding site [chemical binding]; other site 357809006357 Mg2+ binding site [ion binding]; other site 357809006358 G-X-G motif; other site 357809006359 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357809006360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357809006361 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 357809006362 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 357809006363 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 357809006364 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 357809006365 B12 binding site [chemical binding]; other site 357809006366 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 357809006367 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809006368 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809006369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357809006370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006371 dimer interface [polypeptide binding]; other site 357809006372 conserved gate region; other site 357809006373 putative PBP binding loops; other site 357809006374 ABC-ATPase subunit interface; other site 357809006375 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 357809006376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006377 dimer interface [polypeptide binding]; other site 357809006378 conserved gate region; other site 357809006379 putative PBP binding loops; other site 357809006380 ABC-ATPase subunit interface; other site 357809006381 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357809006382 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809006383 Walker A/P-loop; other site 357809006384 ATP binding site [chemical binding]; other site 357809006385 Q-loop/lid; other site 357809006386 ABC transporter signature motif; other site 357809006387 Walker B; other site 357809006388 D-loop; other site 357809006389 H-loop/switch region; other site 357809006390 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357809006391 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 357809006392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809006393 Walker A/P-loop; other site 357809006394 ATP binding site [chemical binding]; other site 357809006395 Q-loop/lid; other site 357809006396 ABC transporter signature motif; other site 357809006397 Walker B; other site 357809006398 D-loop; other site 357809006399 H-loop/switch region; other site 357809006400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357809006401 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 357809006402 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 357809006403 peptide binding site [polypeptide binding]; other site 357809006404 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 357809006405 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357809006406 ATP binding site [chemical binding]; other site 357809006407 Mg++ binding site [ion binding]; other site 357809006408 motif III; other site 357809006409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809006410 nucleotide binding region [chemical binding]; other site 357809006411 ATP-binding site [chemical binding]; other site 357809006412 YCII-related domain; Region: YCII; cl00999 357809006413 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 357809006414 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809006415 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 357809006416 NlpC/P60 family; Region: NLPC_P60; cl17555 357809006417 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 357809006418 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 357809006419 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 357809006420 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 357809006421 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357809006422 ATP binding site [chemical binding]; other site 357809006423 Mg++ binding site [ion binding]; other site 357809006424 motif III; other site 357809006425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809006426 nucleotide binding region [chemical binding]; other site 357809006427 ATP-binding site [chemical binding]; other site 357809006428 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 357809006429 Response regulator receiver domain; Region: Response_reg; pfam00072 357809006430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809006431 active site 357809006432 phosphorylation site [posttranslational modification] 357809006433 intermolecular recognition site; other site 357809006434 dimerization interface [polypeptide binding]; other site 357809006435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809006436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809006437 Cache domain; Region: Cache_1; pfam02743 357809006438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809006439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809006440 dimerization interface [polypeptide binding]; other site 357809006441 Histidine kinase; Region: His_kinase; pfam06580 357809006442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809006443 ATP binding site [chemical binding]; other site 357809006444 Mg2+ binding site [ion binding]; other site 357809006445 G-X-G motif; other site 357809006446 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 357809006447 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357809006448 putative ligand binding site [chemical binding]; other site 357809006449 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357809006450 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809006451 Walker A/P-loop; other site 357809006452 ATP binding site [chemical binding]; other site 357809006453 Q-loop/lid; other site 357809006454 ABC transporter signature motif; other site 357809006455 Walker B; other site 357809006456 D-loop; other site 357809006457 H-loop/switch region; other site 357809006458 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809006459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809006460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809006461 TM-ABC transporter signature motif; other site 357809006462 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357809006463 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357809006464 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 357809006465 reactive center loop; other site 357809006466 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 357809006467 reactive center loop; other site 357809006468 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 357809006469 Predicted transcriptional regulators [Transcription]; Region: COG1695 357809006470 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357809006471 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 357809006472 GAF domain; Region: GAF_2; pfam13185 357809006473 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809006474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006475 Walker A/P-loop; other site 357809006476 ATP binding site [chemical binding]; other site 357809006477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809006478 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809006479 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 357809006480 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357809006481 endonuclease III; Region: ENDO3c; smart00478 357809006482 minor groove reading motif; other site 357809006483 helix-hairpin-helix signature motif; other site 357809006484 active site 357809006485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 357809006486 SPFH domain / Band 7 family; Region: Band_7; pfam01145 357809006487 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 357809006488 DNA polymerase II large subunit; Provisional; Region: PRK14714 357809006489 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357809006490 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357809006491 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357809006492 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 357809006493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809006494 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357809006495 active site 357809006496 catalytic tetrad [active] 357809006497 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 357809006498 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 357809006499 inhibitor binding site; inhibition site 357809006500 active site 357809006501 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 357809006502 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 357809006503 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 357809006504 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 357809006505 intersubunit interface [polypeptide binding]; other site 357809006506 active site 357809006507 Zn2+ binding site [ion binding]; other site 357809006508 purine nucleoside phosphorylase; Provisional; Region: PRK08202 357809006509 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 357809006510 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 357809006511 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 357809006512 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357809006513 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 357809006514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006515 Walker A/P-loop; other site 357809006516 ATP binding site [chemical binding]; other site 357809006517 Q-loop/lid; other site 357809006518 ABC transporter signature motif; other site 357809006519 Walker B; other site 357809006520 D-loop; other site 357809006521 H-loop/switch region; other site 357809006522 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809006523 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809006524 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809006525 TM-ABC transporter signature motif; other site 357809006526 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809006527 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809006528 TM-ABC transporter signature motif; other site 357809006529 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 357809006530 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 357809006531 active site 357809006532 putative substrate binding pocket [chemical binding]; other site 357809006533 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809006534 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 357809006535 DNA binding residues [nucleotide binding] 357809006536 dimer interface [polypeptide binding]; other site 357809006537 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 357809006538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809006539 Coenzyme A binding pocket [chemical binding]; other site 357809006540 Predicted transcriptional regulator [Transcription]; Region: COG2378 357809006541 HTH domain; Region: HTH_11; pfam08279 357809006542 WYL domain; Region: WYL; pfam13280 357809006543 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357809006544 homotrimer interaction site [polypeptide binding]; other site 357809006545 putative active site [active] 357809006546 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 357809006547 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 357809006548 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 357809006549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809006550 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357809006551 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809006552 Uncharacterized conserved protein [Function unknown]; Region: COG2454 357809006553 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 357809006554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809006555 Walker A motif; other site 357809006556 ATP binding site [chemical binding]; other site 357809006557 Walker B motif; other site 357809006558 arginine finger; other site 357809006559 Peptidase family M41; Region: Peptidase_M41; pfam01434 357809006560 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 357809006561 TM-ABC transporter signature motif; other site 357809006562 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809006563 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 357809006564 TM-ABC transporter signature motif; other site 357809006565 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357809006566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006567 Walker A/P-loop; other site 357809006568 ATP binding site [chemical binding]; other site 357809006569 Q-loop/lid; other site 357809006570 ABC transporter signature motif; other site 357809006571 Walker B; other site 357809006572 D-loop; other site 357809006573 H-loop/switch region; other site 357809006574 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809006575 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 357809006576 SLBB domain; Region: SLBB; pfam10531 357809006577 4Fe-4S binding domain; Region: Fer4; pfam00037 357809006578 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 357809006579 4Fe-4S binding domain; Region: Fer4; pfam00037 357809006580 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 357809006581 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 357809006582 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 357809006583 putative substrate binding pocket [chemical binding]; other site 357809006584 AC domain interface; other site 357809006585 catalytic triad [active] 357809006586 AB domain interface; other site 357809006587 interchain disulfide; other site 357809006588 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 357809006589 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 357809006590 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 357809006591 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 357809006592 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809006593 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357809006594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006595 Walker A/P-loop; other site 357809006596 ATP binding site [chemical binding]; other site 357809006597 Q-loop/lid; other site 357809006598 ABC transporter signature motif; other site 357809006599 Walker B; other site 357809006600 D-loop; other site 357809006601 H-loop/switch region; other site 357809006602 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809006603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006604 Walker A/P-loop; other site 357809006605 ATP binding site [chemical binding]; other site 357809006606 Q-loop/lid; other site 357809006607 ABC transporter signature motif; other site 357809006608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006609 H-loop/switch region; other site 357809006610 glycyl-tRNA synthetase; Provisional; Region: PRK04173 357809006611 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357809006612 motif 1; other site 357809006613 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 357809006614 active site 357809006615 motif 2; other site 357809006616 motif 3; other site 357809006617 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 357809006618 anticodon binding site; other site 357809006619 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 357809006620 Penicillinase repressor; Region: Pencillinase_R; cl17580 357809006621 hypothetical protein; Provisional; Region: PRK06761 357809006622 Predicted transcriptional regulators [Transcription]; Region: COG1695 357809006623 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357809006624 L-fucose isomerase, C-terminal domain; Region: Fucose_iso_C; pfam02952 357809006625 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 357809006626 Flavin Reductases; Region: FlaRed; cl00801 357809006627 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 357809006628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809006629 motif II; other site 357809006630 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 357809006631 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 357809006632 active site 357809006633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809006634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809006635 active site 357809006636 phosphorylation site [posttranslational modification] 357809006637 intermolecular recognition site; other site 357809006638 dimerization interface [polypeptide binding]; other site 357809006639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809006640 DNA binding site [nucleotide binding] 357809006641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809006642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809006643 dimer interface [polypeptide binding]; other site 357809006644 phosphorylation site [posttranslational modification] 357809006645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809006646 ATP binding site [chemical binding]; other site 357809006647 Mg2+ binding site [ion binding]; other site 357809006648 G-X-G motif; other site 357809006649 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809006650 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809006651 Walker A/P-loop; other site 357809006652 ATP binding site [chemical binding]; other site 357809006653 Q-loop/lid; other site 357809006654 ABC transporter signature motif; other site 357809006655 Walker B; other site 357809006656 D-loop; other site 357809006657 H-loop/switch region; other site 357809006658 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809006659 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 357809006660 FtsX-like permease family; Region: FtsX; pfam02687 357809006661 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809006662 FtsX-like permease family; Region: FtsX; pfam02687 357809006663 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 357809006664 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 357809006665 active site 357809006666 metal binding site [ion binding]; metal-binding site 357809006667 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 357809006668 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 357809006669 G1 box; other site 357809006670 GTP/Mg2+ binding site [chemical binding]; other site 357809006671 Switch I region; other site 357809006672 G2 box; other site 357809006673 Switch II region; other site 357809006674 G3 box; other site 357809006675 G4 box; other site 357809006676 G5 box; other site 357809006677 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 357809006678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809006679 FeS/SAM binding site; other site 357809006680 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 357809006681 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 357809006682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809006683 FeS/SAM binding site; other site 357809006684 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 357809006685 Heme NO binding; Region: HNOB; pfam07700 357809006686 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357809006687 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809006688 dimer interface [polypeptide binding]; other site 357809006689 putative CheW interface [polypeptide binding]; other site 357809006690 PQQ-like domain; Region: PQQ_2; pfam13360 357809006691 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357809006692 Trp docking motif [polypeptide binding]; other site 357809006693 active site 357809006694 PQQ-like domain; Region: PQQ_2; pfam13360 357809006695 FOG: WD40-like repeat [Function unknown]; Region: COG1520 357809006696 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357809006697 Trp docking motif [polypeptide binding]; other site 357809006698 active site 357809006699 phosphodiesterase YaeI; Provisional; Region: PRK11340 357809006700 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 357809006701 putative active site [active] 357809006702 putative metal binding site [ion binding]; other site 357809006703 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809006704 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809006705 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809006706 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 357809006707 active site 357809006708 Coat F domain; Region: Coat_F; pfam07875 357809006709 Predicted amidohydrolase [General function prediction only]; Region: COG0388 357809006710 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 357809006711 active site 357809006712 catalytic triad [active] 357809006713 dimer interface [polypeptide binding]; other site 357809006714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809006715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357809006716 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357809006717 active site 357809006718 DNA binding site [nucleotide binding] 357809006719 Int/Topo IB signature motif; other site 357809006720 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 357809006721 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 357809006722 MOFRL family; Region: MOFRL; pfam05161 357809006723 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 357809006724 fructuronate transporter; Provisional; Region: PRK10034; cl15264 357809006725 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 357809006726 Uncharacterized conserved protein [Function unknown]; Region: COG1262 357809006727 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 357809006728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809006729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809006730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 357809006731 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 357809006732 Phosphotransferase enzyme family; Region: APH; pfam01636 357809006733 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809006734 active site 357809006735 ATP binding site [chemical binding]; other site 357809006736 substrate binding site [chemical binding]; other site 357809006737 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 357809006738 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 357809006739 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357809006740 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809006741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809006742 non-specific DNA binding site [nucleotide binding]; other site 357809006743 salt bridge; other site 357809006744 sequence-specific DNA binding site [nucleotide binding]; other site 357809006745 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809006746 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809006747 Walker A/P-loop; other site 357809006748 ATP binding site [chemical binding]; other site 357809006749 Q-loop/lid; other site 357809006750 ABC transporter signature motif; other site 357809006751 Walker B; other site 357809006752 D-loop; other site 357809006753 H-loop/switch region; other site 357809006754 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 357809006755 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 357809006756 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 357809006757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809006758 putative substrate translocation pore; other site 357809006759 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809006760 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357809006761 active site 357809006762 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 357809006763 Rubredoxin; Region: Rubredoxin; pfam00301 357809006764 iron binding site [ion binding]; other site 357809006765 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357809006766 metal-binding site [ion binding] 357809006767 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 357809006768 Family description; Region: DsbD_2; pfam13386 357809006769 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 357809006770 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 357809006771 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 357809006772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809006773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809006774 active site 357809006775 phosphorylation site [posttranslational modification] 357809006776 intermolecular recognition site; other site 357809006777 dimerization interface [polypeptide binding]; other site 357809006778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809006779 DNA binding site [nucleotide binding] 357809006780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809006781 HAMP domain; Region: HAMP; pfam00672 357809006782 dimerization interface [polypeptide binding]; other site 357809006783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809006784 dimer interface [polypeptide binding]; other site 357809006785 phosphorylation site [posttranslational modification] 357809006786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809006787 ATP binding site [chemical binding]; other site 357809006788 Mg2+ binding site [ion binding]; other site 357809006789 G-X-G motif; other site 357809006790 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809006791 L-aspartate dehydrogenase; Reviewed; Region: PRK13304 357809006792 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 357809006793 Domain of unknown function DUF108; Region: DUF108; pfam01958 357809006794 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_9; cd12170 357809006795 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 357809006796 putative ligand binding site [chemical binding]; other site 357809006797 putative NAD binding site [chemical binding]; other site 357809006798 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357809006799 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357809006800 Beta propeller domain; Region: Beta_propel; pfam09826 357809006801 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 357809006802 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 357809006803 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 357809006804 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 357809006805 Cellulose binding domain; Region: CBM_3; pfam00942 357809006806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809006807 dimerization interface [polypeptide binding]; other site 357809006808 putative DNA binding site [nucleotide binding]; other site 357809006809 putative Zn2+ binding site [ion binding]; other site 357809006810 Domain of unknown function, E. rectale Gene description (DUF3877); Region: DUF3877; pfam12993 357809006811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357809006812 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809006813 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357809006814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809006815 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357809006816 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357809006817 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809006818 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 357809006819 putative homodimer interface [polypeptide binding]; other site 357809006820 putative homotetramer interface [polypeptide binding]; other site 357809006821 putative metal binding site [ion binding]; other site 357809006822 putative homodimer-homodimer interface [polypeptide binding]; other site 357809006823 putative allosteric switch controlling residues; other site 357809006824 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 357809006825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809006826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006827 Walker A/P-loop; other site 357809006828 ATP binding site [chemical binding]; other site 357809006829 Q-loop/lid; other site 357809006830 ABC transporter signature motif; other site 357809006831 Walker B; other site 357809006832 D-loop; other site 357809006833 H-loop/switch region; other site 357809006834 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 357809006835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006836 Walker A/P-loop; other site 357809006837 ATP binding site [chemical binding]; other site 357809006838 Q-loop/lid; other site 357809006839 ABC transporter signature motif; other site 357809006840 Walker B; other site 357809006841 D-loop; other site 357809006842 H-loop/switch region; other site 357809006843 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809006844 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809006845 MarR family; Region: MarR_2; pfam12802 357809006846 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 357809006847 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357809006848 HAMP domain; Region: HAMP; pfam00672 357809006849 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809006850 Histidine kinase; Region: His_kinase; pfam06580 357809006851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809006852 ATP binding site [chemical binding]; other site 357809006853 Mg2+ binding site [ion binding]; other site 357809006854 G-X-G motif; other site 357809006855 Response regulator receiver domain; Region: Response_reg; pfam00072 357809006856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809006857 active site 357809006858 phosphorylation site [posttranslational modification] 357809006859 intermolecular recognition site; other site 357809006860 dimerization interface [polypeptide binding]; other site 357809006861 Helix-turn-helix domain; Region: HTH_18; pfam12833 357809006862 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 357809006863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006864 dimer interface [polypeptide binding]; other site 357809006865 conserved gate region; other site 357809006866 putative PBP binding loops; other site 357809006867 ABC-ATPase subunit interface; other site 357809006868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006869 dimer interface [polypeptide binding]; other site 357809006870 conserved gate region; other site 357809006871 ABC-ATPase subunit interface; other site 357809006872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006873 AAA domain; Region: AAA_21; pfam13304 357809006874 Walker A/P-loop; other site 357809006875 ATP binding site [chemical binding]; other site 357809006876 Q-loop/lid; other site 357809006877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809006878 ABC transporter signature motif; other site 357809006879 Walker B; other site 357809006880 D-loop; other site 357809006881 H-loop/switch region; other site 357809006882 TOBE domain; Region: TOBE_2; pfam08402 357809006883 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 357809006884 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 357809006885 DNA polymerase IV; Reviewed; Region: PRK03103 357809006886 Y-family of DNA polymerases; Region: PolY; cl12025 357809006887 active site 357809006888 DNA binding site [nucleotide binding] 357809006889 YolD-like protein; Region: YolD; pfam08863 357809006890 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809006891 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357809006892 active site 357809006893 metal binding site [ion binding]; metal-binding site 357809006894 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357809006895 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809006896 putative DNA binding site [nucleotide binding]; other site 357809006897 dimerization interface [polypeptide binding]; other site 357809006898 putative Zn2+ binding site [ion binding]; other site 357809006899 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 357809006900 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 357809006901 P loop; other site 357809006902 Nucleotide binding site [chemical binding]; other site 357809006903 DTAP/Switch II; other site 357809006904 Switch I; other site 357809006905 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 357809006906 P loop; other site 357809006907 Nucleotide binding site [chemical binding]; other site 357809006908 DTAP/Switch II; other site 357809006909 Switch I; other site 357809006910 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 357809006911 arsenical-resistance protein; Region: acr3; TIGR00832 357809006912 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 357809006913 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 357809006914 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357809006915 active site 357809006916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809006917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809006918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809006919 dimerization interface [polypeptide binding]; other site 357809006920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809006921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809006922 catalytic residue [active] 357809006923 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 357809006924 RRNA methyltransferase AviRa; Region: AviRa; pfam11599 357809006925 Cupin domain; Region: Cupin_2; cl17218 357809006926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809006927 Coenzyme A binding pocket [chemical binding]; other site 357809006928 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 357809006929 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 357809006930 FMN binding site [chemical binding]; other site 357809006931 dimer interface [polypeptide binding]; other site 357809006932 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 357809006933 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 357809006934 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 357809006935 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357809006936 HSP70 interaction site [polypeptide binding]; other site 357809006937 putative transposase OrfB; Reviewed; Region: PHA02517 357809006938 HTH-like domain; Region: HTH_21; pfam13276 357809006939 Integrase core domain; Region: rve; pfam00665 357809006940 Integrase core domain; Region: rve_2; pfam13333 357809006941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 357809006942 Helix-turn-helix domain; Region: HTH_28; pfam13518 357809006943 Helix-turn-helix domain; Region: HTH_28; pfam13518 357809006944 Winged helix-turn helix; Region: HTH_29; pfam13551 357809006945 AAA domain; Region: AAA_22; pfam13401 357809006946 CGGC domain; Region: CGGC; pfam08821 357809006947 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 357809006948 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 357809006949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809006950 catalytic residue [active] 357809006951 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809006952 dimerization interface [polypeptide binding]; other site 357809006953 putative DNA binding site [nucleotide binding]; other site 357809006954 putative Zn2+ binding site [ion binding]; other site 357809006955 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357809006956 active site residue [active] 357809006957 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 357809006958 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809006959 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809006960 catalytic residue [active] 357809006961 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357809006962 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 357809006963 active site 357809006964 nucleophile elbow; other site 357809006965 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 357809006966 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 357809006967 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 357809006968 interface (dimer of trimers) [polypeptide binding]; other site 357809006969 Substrate-binding/catalytic site; other site 357809006970 Zn-binding sites [ion binding]; other site 357809006971 Uncharacterized conserved protein [Function unknown]; Region: COG1284 357809006972 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809006973 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809006974 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 357809006975 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357809006976 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809006977 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809006978 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809006979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809006980 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357809006981 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 357809006982 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 357809006983 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809006984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006985 dimer interface [polypeptide binding]; other site 357809006986 conserved gate region; other site 357809006987 ABC-ATPase subunit interface; other site 357809006988 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809006989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809006990 dimer interface [polypeptide binding]; other site 357809006991 conserved gate region; other site 357809006992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809006993 ABC-ATPase subunit interface; other site 357809006994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809006995 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357809006996 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 357809006997 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 357809006998 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357809006999 active site 357809007000 Int/Topo IB signature motif; other site 357809007001 DNA binding site [nucleotide binding] 357809007002 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 357809007003 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357809007004 DNA binding site [nucleotide binding] 357809007005 active site 357809007006 Int/Topo IB signature motif; other site 357809007007 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809007008 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 357809007009 Walker A/P-loop; other site 357809007010 ATP binding site [chemical binding]; other site 357809007011 Q-loop/lid; other site 357809007012 ABC transporter signature motif; other site 357809007013 Walker B; other site 357809007014 D-loop; other site 357809007015 H-loop/switch region; other site 357809007016 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809007017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809007018 Walker A/P-loop; other site 357809007019 ATP binding site [chemical binding]; other site 357809007020 Q-loop/lid; other site 357809007021 ABC transporter signature motif; other site 357809007022 Walker B; other site 357809007023 D-loop; other site 357809007024 H-loop/switch region; other site 357809007025 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357809007026 Transposase; Region: HTH_Tnp_1; cl17663 357809007027 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 357809007028 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 357809007029 active site 357809007030 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357809007031 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357809007032 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 357809007033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809007034 DXD motif; other site 357809007035 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809007036 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357809007037 NodB motif; other site 357809007038 active site 357809007039 metal binding site [ion binding]; metal-binding site 357809007040 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809007041 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357809007042 NodB motif; other site 357809007043 active site 357809007044 catalytic site [active] 357809007045 metal binding site [ion binding]; metal-binding site 357809007046 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357809007047 NodB motif; other site 357809007048 active site 357809007049 catalytic site [active] 357809007050 metal binding site [ion binding]; metal-binding site 357809007051 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 357809007052 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 357809007053 NodB motif; other site 357809007054 active site 357809007055 catalytic site [active] 357809007056 metal binding site [ion binding]; metal-binding site 357809007057 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 357809007058 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357809007059 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 357809007060 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 357809007061 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 357809007062 AAA domain; Region: AAA_18; pfam13238 357809007063 P-loop motif; other site 357809007064 ATP binding site [chemical binding]; other site 357809007065 Chloramphenicol (Cm) binding site [chemical binding]; other site 357809007066 catalytic residue [active] 357809007067 hypothetical protein; Provisional; Region: PRK06761 357809007068 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809007069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809007070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809007071 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 357809007072 ABC transporter ATPase component; Reviewed; Region: PRK11147 357809007073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809007074 Coenzyme A binding pocket [chemical binding]; other site 357809007075 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 357809007076 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357809007077 catalytic residues [active] 357809007078 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357809007079 EamA-like transporter family; Region: EamA; pfam00892 357809007080 EamA-like transporter family; Region: EamA; pfam00892 357809007081 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357809007082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809007083 DNA-binding site [nucleotide binding]; DNA binding site 357809007084 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809007085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809007086 homodimer interface [polypeptide binding]; other site 357809007087 catalytic residue [active] 357809007088 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 357809007089 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 357809007090 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 357809007091 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357809007092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809007093 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357809007094 Beta-lactamase; Region: Beta-lactamase; pfam00144 357809007095 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809007096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809007097 Walker A/P-loop; other site 357809007098 ATP binding site [chemical binding]; other site 357809007099 Q-loop/lid; other site 357809007100 ABC transporter signature motif; other site 357809007101 Walker B; other site 357809007102 D-loop; other site 357809007103 H-loop/switch region; other site 357809007104 Predicted transcriptional regulators [Transcription]; Region: COG1725 357809007105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809007106 DNA-binding site [nucleotide binding]; DNA binding site 357809007107 CAAX protease self-immunity; Region: Abi; pfam02517 357809007108 galactokinase; Provisional; Region: PRK05322 357809007109 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 357809007110 Cupin domain; Region: Cupin_2; pfam07883 357809007111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809007112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809007113 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 357809007114 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809007115 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809007116 TM-ABC transporter signature motif; other site 357809007117 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809007118 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 357809007119 Walker A/P-loop; other site 357809007120 ATP binding site [chemical binding]; other site 357809007121 Q-loop/lid; other site 357809007122 ABC transporter signature motif; other site 357809007123 Walker B; other site 357809007124 D-loop; other site 357809007125 H-loop/switch region; other site 357809007126 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809007127 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 357809007128 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 357809007129 ligand binding site [chemical binding]; other site 357809007130 calcium binding site [ion binding]; other site 357809007131 WYL domain; Region: WYL; cl14852 357809007132 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 357809007133 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357809007134 putative ligand binding site [chemical binding]; other site 357809007135 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809007136 Cache domain; Region: Cache_1; pfam02743 357809007137 HAMP domain; Region: HAMP; pfam00672 357809007138 Histidine kinase; Region: His_kinase; pfam06580 357809007139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809007140 ATP binding site [chemical binding]; other site 357809007141 Mg2+ binding site [ion binding]; other site 357809007142 G-X-G motif; other site 357809007143 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 357809007144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809007145 active site 357809007146 phosphorylation site [posttranslational modification] 357809007147 intermolecular recognition site; other site 357809007148 dimerization interface [polypeptide binding]; other site 357809007149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809007150 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357809007151 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357809007152 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 357809007153 active site 357809007154 substrate binding site [chemical binding]; other site 357809007155 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 357809007156 FMN binding site [chemical binding]; other site 357809007157 putative catalytic residues [active] 357809007158 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 357809007159 active site 357809007160 metal binding site [ion binding]; metal-binding site 357809007161 homotetramer interface [polypeptide binding]; other site 357809007162 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 357809007163 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 357809007164 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 357809007165 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 357809007166 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 357809007167 active site 357809007168 metal binding site [ion binding]; metal-binding site 357809007169 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 357809007170 Ligand Binding Site [chemical binding]; other site 357809007171 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 357809007172 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 357809007173 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 357809007174 active site 357809007175 substrate binding site [chemical binding]; other site 357809007176 metal binding site [ion binding]; metal-binding site 357809007177 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 357809007178 dimerization interface [polypeptide binding]; other site 357809007179 putative active cleft [active] 357809007180 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 357809007181 active site 357809007182 catalytic triad [active] 357809007183 oxyanion hole [active] 357809007184 Domain of unknown function (DUF377); Region: DUF377; pfam04041 357809007185 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 357809007186 active site 357809007187 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809007188 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809007189 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809007190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007191 dimer interface [polypeptide binding]; other site 357809007192 conserved gate region; other site 357809007193 ABC-ATPase subunit interface; other site 357809007194 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809007195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007196 dimer interface [polypeptide binding]; other site 357809007197 ABC-ATPase subunit interface; other site 357809007198 putative PBP binding loops; other site 357809007199 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809007200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007201 dimer interface [polypeptide binding]; other site 357809007202 conserved gate region; other site 357809007203 ABC-ATPase subunit interface; other site 357809007204 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809007205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007206 dimer interface [polypeptide binding]; other site 357809007207 conserved gate region; other site 357809007208 putative PBP binding loops; other site 357809007209 ABC-ATPase subunit interface; other site 357809007210 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 357809007211 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 357809007212 putative metal binding site [ion binding]; other site 357809007213 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357809007214 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809007215 Protein of unknown function, DUF624; Region: DUF624; pfam04854 357809007216 Protein of unknown function, DUF624; Region: DUF624; cl02369 357809007217 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 357809007218 putative metal binding site [ion binding]; other site 357809007219 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 357809007220 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809007221 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809007222 DNA binding site [nucleotide binding] 357809007223 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357809007224 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 357809007225 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 357809007226 Stage II sporulation protein; Region: SpoIID; pfam08486 357809007227 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 357809007228 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 357809007229 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 357809007230 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357809007231 Catalytic site [active] 357809007232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809007233 active site 357809007234 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 357809007235 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 357809007236 heterodimer interface [polypeptide binding]; other site 357809007237 active site 357809007238 FMN binding site [chemical binding]; other site 357809007239 homodimer interface [polypeptide binding]; other site 357809007240 substrate binding site [chemical binding]; other site 357809007241 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 357809007242 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 357809007243 FAD binding pocket [chemical binding]; other site 357809007244 FAD binding motif [chemical binding]; other site 357809007245 phosphate binding motif [ion binding]; other site 357809007246 beta-alpha-beta structure motif; other site 357809007247 NAD binding pocket [chemical binding]; other site 357809007248 Iron coordination center [ion binding]; other site 357809007249 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 357809007250 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357809007251 Peptidase family M23; Region: Peptidase_M23; pfam01551 357809007252 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 357809007253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809007254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809007255 DNA binding residues [nucleotide binding] 357809007256 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 357809007257 Peptidase family U32; Region: Peptidase_U32; pfam01136 357809007258 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 357809007259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809007260 S-adenosylmethionine binding site [chemical binding]; other site 357809007261 YceG-like family; Region: YceG; pfam02618 357809007262 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 357809007263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809007264 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 357809007265 ferric uptake regulator; Provisional; Region: fur; PRK09462 357809007266 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 357809007267 metal binding site 2 [ion binding]; metal-binding site 357809007268 putative DNA binding helix; other site 357809007269 metal binding site 1 [ion binding]; metal-binding site 357809007270 dimer interface [polypeptide binding]; other site 357809007271 structural Zn2+ binding site [ion binding]; other site 357809007272 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 357809007273 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 357809007274 hypothetical protein; Provisional; Region: PRK05473 357809007275 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 357809007276 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357809007277 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 357809007278 regulatory protein interface [polypeptide binding]; other site 357809007279 regulatory phosphorylation site [posttranslational modification]; other site 357809007280 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 357809007281 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 357809007282 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 357809007283 Ligand Binding Site [chemical binding]; other site 357809007284 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 357809007285 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 357809007286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809007287 catalytic residue [active] 357809007288 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 357809007289 RNA methyltransferase, RsmE family; Region: TIGR00046 357809007290 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 357809007291 carbohydrate binding site [chemical binding]; other site 357809007292 pullulanase, type I; Region: pulA_typeI; TIGR02104 357809007293 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 357809007294 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 357809007295 Ca binding site [ion binding]; other site 357809007296 active site 357809007297 catalytic site [active] 357809007298 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 357809007299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809007300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007301 dimer interface [polypeptide binding]; other site 357809007302 conserved gate region; other site 357809007303 putative PBP binding loops; other site 357809007304 ABC-ATPase subunit interface; other site 357809007305 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357809007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007307 dimer interface [polypeptide binding]; other site 357809007308 conserved gate region; other site 357809007309 putative PBP binding loops; other site 357809007310 ABC-ATPase subunit interface; other site 357809007311 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 357809007312 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809007313 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 357809007314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809007315 S-adenosylmethionine binding site [chemical binding]; other site 357809007316 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 357809007317 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357809007318 HSP70 interaction site [polypeptide binding]; other site 357809007319 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 357809007320 substrate binding site [polypeptide binding]; other site 357809007321 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 357809007322 Zn binding sites [ion binding]; other site 357809007323 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 357809007324 dimer interface [polypeptide binding]; other site 357809007325 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 357809007326 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 357809007327 nucleotide binding site [chemical binding]; other site 357809007328 NEF interaction site [polypeptide binding]; other site 357809007329 SBD interface [polypeptide binding]; other site 357809007330 heat shock protein GrpE; Provisional; Region: PRK14140 357809007331 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 357809007332 dimer interface [polypeptide binding]; other site 357809007333 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 357809007334 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 357809007335 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 357809007336 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 357809007337 HemN C-terminal domain; Region: HemN_C; pfam06969 357809007338 GTP-binding protein LepA; Provisional; Region: PRK05433 357809007339 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 357809007340 G1 box; other site 357809007341 putative GEF interaction site [polypeptide binding]; other site 357809007342 GTP/Mg2+ binding site [chemical binding]; other site 357809007343 Switch I region; other site 357809007344 G2 box; other site 357809007345 G3 box; other site 357809007346 Switch II region; other site 357809007347 G4 box; other site 357809007348 G5 box; other site 357809007349 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 357809007350 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 357809007351 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 357809007352 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 357809007353 stage II sporulation protein P; Region: spore_II_P; TIGR02867 357809007354 germination protease; Provisional; Region: PRK12362 357809007355 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 357809007356 Predicted transcriptional regulators [Transcription]; Region: COG1725 357809007357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809007358 DNA-binding site [nucleotide binding]; DNA binding site 357809007359 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357809007360 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809007361 Walker A/P-loop; other site 357809007362 ATP binding site [chemical binding]; other site 357809007363 Q-loop/lid; other site 357809007364 ABC transporter signature motif; other site 357809007365 Walker B; other site 357809007366 D-loop; other site 357809007367 H-loop/switch region; other site 357809007368 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357809007369 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357809007370 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357809007371 Penicillinase repressor; Region: Pencillinase_R; pfam03965 357809007372 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357809007373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809007374 Zn2+ binding site [ion binding]; other site 357809007375 Mg2+ binding site [ion binding]; other site 357809007376 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 357809007377 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 357809007378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809007379 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809007380 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 357809007381 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 357809007382 Substrate-binding site [chemical binding]; other site 357809007383 Substrate specificity [chemical binding]; other site 357809007384 pullulanase, type I; Region: pulA_typeI; TIGR02104 357809007385 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 357809007386 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 357809007387 Ca binding site [ion binding]; other site 357809007388 active site 357809007389 catalytic site [active] 357809007390 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 357809007391 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 357809007392 Yqey-like protein; Region: YqeY; cl17540 357809007393 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 357809007394 GTP cyclohydrolase I; Provisional; Region: PLN03044 357809007395 active site 357809007396 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 357809007397 active site 357809007398 NTP binding site [chemical binding]; other site 357809007399 metal binding triad [ion binding]; metal-binding site 357809007400 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 357809007401 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 357809007402 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 357809007403 putative ADP-binding pocket [chemical binding]; other site 357809007404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809007405 diaminopimelate epimerase; Provisional; Region: PRK13577 357809007406 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 357809007407 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 357809007408 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809007409 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809007410 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809007411 FtsX-like permease family; Region: FtsX; pfam02687 357809007412 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809007413 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 357809007414 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 357809007415 Ca binding site [ion binding]; other site 357809007416 active site 357809007417 catalytic site [active] 357809007418 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 357809007419 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 357809007420 Ca binding site [ion binding]; other site 357809007421 active site 357809007422 catalytic site [active] 357809007423 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 357809007424 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 357809007425 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 357809007426 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 357809007427 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 357809007428 Ca binding site [ion binding]; other site 357809007429 active site 357809007430 catalytic site [active] 357809007431 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809007432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007433 dimer interface [polypeptide binding]; other site 357809007434 conserved gate region; other site 357809007435 putative PBP binding loops; other site 357809007436 ABC-ATPase subunit interface; other site 357809007437 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357809007438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007439 dimer interface [polypeptide binding]; other site 357809007440 conserved gate region; other site 357809007441 putative PBP binding loops; other site 357809007442 ABC-ATPase subunit interface; other site 357809007443 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 357809007444 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357809007445 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 357809007446 4-alpha-glucanotransferase; Provisional; Region: PRK14508 357809007447 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 357809007448 homodimer interface [polypeptide binding]; other site 357809007449 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 357809007450 active site 357809007451 homodimer interface [polypeptide binding]; other site 357809007452 catalytic site [active] 357809007453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809007454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809007455 DNA binding site [nucleotide binding] 357809007456 domain linker motif; other site 357809007457 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809007458 ligand binding site [chemical binding]; other site 357809007459 dimerization interface [polypeptide binding]; other site 357809007460 aspartate kinase; Reviewed; Region: PRK09034 357809007461 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 357809007462 nucleotide binding site [chemical binding]; other site 357809007463 substrate binding site [chemical binding]; other site 357809007464 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 357809007465 allosteric regulatory residue; other site 357809007466 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 357809007467 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809007468 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809007469 DNA binding site [nucleotide binding] 357809007470 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809007471 ligand binding site [chemical binding]; other site 357809007472 dimerization interface [polypeptide binding]; other site 357809007473 Penicillinase repressor; Region: Pencillinase_R; cl17580 357809007474 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 357809007475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809007476 Walker A motif; other site 357809007477 ATP binding site [chemical binding]; other site 357809007478 Walker B motif; other site 357809007479 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 357809007480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809007481 RNA binding surface [nucleotide binding]; other site 357809007482 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357809007483 active site 357809007484 lipoprotein signal peptidase; Provisional; Region: PRK14767 357809007485 lipoprotein signal peptidase; Provisional; Region: PRK14787 357809007486 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 357809007487 active site 357809007488 dimer interface [polypeptide binding]; other site 357809007489 metal binding site [ion binding]; metal-binding site 357809007490 DivIVA protein; Region: DivIVA; pfam05103 357809007491 DivIVA domain; Region: DivI1A_domain; TIGR03544 357809007492 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 357809007493 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809007494 RNA binding surface [nucleotide binding]; other site 357809007495 Protein of unknown function (DUF552); Region: DUF552; pfam04472 357809007496 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 357809007497 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357809007498 catalytic residue [active] 357809007499 HlyD family secretion protein; Region: HlyD_2; pfam12700 357809007500 putative membrane fusion protein; Region: TIGR02828 357809007501 Uncharacterized conserved protein [Function unknown]; Region: COG2155 357809007502 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 357809007503 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357809007504 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 357809007505 active site 357809007506 dimer interfaces [polypeptide binding]; other site 357809007507 catalytic residues [active] 357809007508 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 357809007509 Septum formation topological specificity factor MinE; Region: MinE; cl00538 357809007510 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 357809007511 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 357809007512 Switch I; other site 357809007513 Switch II; other site 357809007514 septum formation inhibitor; Reviewed; Region: minC; PRK00513 357809007515 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 357809007516 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357809007517 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357809007518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357809007519 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 357809007520 rod shape-determining protein MreC; Provisional; Region: PRK13922 357809007521 rod shape-determining protein MreC; Region: MreC; pfam04085 357809007522 rod shape-determining protein MreB; Provisional; Region: PRK13927 357809007523 MreB and similar proteins; Region: MreB_like; cd10225 357809007524 nucleotide binding site [chemical binding]; other site 357809007525 Mg binding site [ion binding]; other site 357809007526 putative protofilament interaction site [polypeptide binding]; other site 357809007527 RodZ interaction site [polypeptide binding]; other site 357809007528 hypothetical protein; Reviewed; Region: PRK00024 357809007529 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 357809007530 MPN+ (JAMM) motif; other site 357809007531 Zinc-binding site [ion binding]; other site 357809007532 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 357809007533 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 357809007534 Aluminium resistance protein; Region: Alum_res; pfam06838 357809007535 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 357809007536 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 357809007537 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 357809007538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809007539 ATP binding site [chemical binding]; other site 357809007540 Mg2+ binding site [ion binding]; other site 357809007541 G-X-G motif; other site 357809007542 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 357809007543 ATP binding site [chemical binding]; other site 357809007544 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 357809007545 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 357809007546 MutS domain I; Region: MutS_I; pfam01624 357809007547 MutS domain II; Region: MutS_II; pfam05188 357809007548 MutS domain III; Region: MutS_III; pfam05192 357809007549 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 357809007550 Walker A/P-loop; other site 357809007551 ATP binding site [chemical binding]; other site 357809007552 Q-loop/lid; other site 357809007553 ABC transporter signature motif; other site 357809007554 Walker B; other site 357809007555 D-loop; other site 357809007556 H-loop/switch region; other site 357809007557 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 357809007558 RNA/DNA hybrid binding site [nucleotide binding]; other site 357809007559 active site 357809007560 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 357809007561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809007562 Walker A/P-loop; other site 357809007563 ATP binding site [chemical binding]; other site 357809007564 Q-loop/lid; other site 357809007565 ABC transporter signature motif; other site 357809007566 Walker B; other site 357809007567 D-loop; other site 357809007568 H-loop/switch region; other site 357809007569 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809007570 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 357809007571 NlpC/P60 family; Region: NLPC_P60; pfam00877 357809007572 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 357809007573 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 357809007574 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 357809007575 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 357809007576 ATP-binding site [chemical binding]; other site 357809007577 Sugar specificity; other site 357809007578 Pyrimidine base specificity; other site 357809007579 hypothetical protein; Provisional; Region: PRK09273 357809007580 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 357809007581 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 357809007582 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 357809007583 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 357809007584 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 357809007585 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 357809007586 GTP-binding protein Der; Reviewed; Region: PRK00093 357809007587 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 357809007588 G1 box; other site 357809007589 GTP/Mg2+ binding site [chemical binding]; other site 357809007590 Switch I region; other site 357809007591 G2 box; other site 357809007592 Switch II region; other site 357809007593 G3 box; other site 357809007594 G4 box; other site 357809007595 G5 box; other site 357809007596 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 357809007597 G1 box; other site 357809007598 GTP/Mg2+ binding site [chemical binding]; other site 357809007599 Switch I region; other site 357809007600 G2 box; other site 357809007601 G3 box; other site 357809007602 Switch II region; other site 357809007603 G4 box; other site 357809007604 G5 box; other site 357809007605 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 357809007606 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 357809007607 Protein of unknown function (DUF512); Region: DUF512; pfam04459 357809007608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357809007609 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 357809007610 intersubunit interface [polypeptide binding]; other site 357809007611 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357809007612 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357809007613 ABC-ATPase subunit interface; other site 357809007614 dimer interface [polypeptide binding]; other site 357809007615 putative PBP binding regions; other site 357809007616 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 357809007617 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357809007618 Walker A/P-loop; other site 357809007619 ATP binding site [chemical binding]; other site 357809007620 Q-loop/lid; other site 357809007621 ABC transporter signature motif; other site 357809007622 Walker B; other site 357809007623 D-loop; other site 357809007624 H-loop/switch region; other site 357809007625 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 357809007626 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 357809007627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809007628 active site 357809007629 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 357809007630 Domain of unknown function DUF; Region: DUF204; pfam02659 357809007631 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 357809007632 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 357809007633 hypothetical protein; Reviewed; Region: PRK12497 357809007634 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 357809007635 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 357809007636 RNA/DNA hybrid binding site [nucleotide binding]; other site 357809007637 active site 357809007638 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 357809007639 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 357809007640 GTP/Mg2+ binding site [chemical binding]; other site 357809007641 G4 box; other site 357809007642 G5 box; other site 357809007643 G1 box; other site 357809007644 Switch I region; other site 357809007645 G2 box; other site 357809007646 G3 box; other site 357809007647 Switch II region; other site 357809007648 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357809007649 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 357809007650 Catalytic site [active] 357809007651 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 357809007652 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809007653 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 357809007654 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 357809007655 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 357809007656 RimM N-terminal domain; Region: RimM; pfam01782 357809007657 PRC-barrel domain; Region: PRC; pfam05239 357809007658 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 357809007659 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 357809007660 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 357809007661 signal recognition particle protein; Provisional; Region: PRK10867 357809007662 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 357809007663 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 357809007664 P loop; other site 357809007665 GTP binding site [chemical binding]; other site 357809007666 Signal peptide binding domain; Region: SRP_SPB; pfam02978 357809007667 putative DNA-binding protein; Validated; Region: PRK00118 357809007668 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 357809007669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809007670 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357809007671 active site 357809007672 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 357809007673 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 357809007674 putative active site [active] 357809007675 metal binding site [ion binding]; metal-binding site 357809007676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809007677 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357809007678 Coenzyme A binding pocket [chemical binding]; other site 357809007679 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 357809007680 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 357809007681 tetrameric interface [polypeptide binding]; other site 357809007682 activator binding site; other site 357809007683 NADP binding site [chemical binding]; other site 357809007684 substrate binding site [chemical binding]; other site 357809007685 catalytic residues [active] 357809007686 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 357809007687 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357809007688 Membrane protein of unknown function; Region: DUF360; cl00850 357809007689 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357809007690 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 357809007691 putative active site [active] 357809007692 putative metal binding site [ion binding]; other site 357809007693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809007694 non-specific DNA binding site [nucleotide binding]; other site 357809007695 salt bridge; other site 357809007696 sequence-specific DNA binding site [nucleotide binding]; other site 357809007697 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809007698 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 357809007699 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809007700 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809007701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809007702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809007703 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809007704 Walker A/P-loop; other site 357809007705 ATP binding site [chemical binding]; other site 357809007706 Q-loop/lid; other site 357809007707 ABC transporter signature motif; other site 357809007708 Walker B; other site 357809007709 D-loop; other site 357809007710 H-loop/switch region; other site 357809007711 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809007712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809007713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809007714 Walker A/P-loop; other site 357809007715 ATP binding site [chemical binding]; other site 357809007716 Q-loop/lid; other site 357809007717 ABC transporter signature motif; other site 357809007718 Walker B; other site 357809007719 D-loop; other site 357809007720 H-loop/switch region; other site 357809007721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809007722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809007723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809007724 dimerization interface [polypeptide binding]; other site 357809007725 Protein of unknown function (DUF2817); Region: DUF2817; pfam10994 357809007726 active site 357809007727 Zn binding site [ion binding]; other site 357809007728 oxaloacetate decarboxylase; Provisional; Region: PRK12331 357809007729 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 357809007730 active site 357809007731 catalytic residues [active] 357809007732 metal binding site [ion binding]; metal-binding site 357809007733 homodimer binding site [polypeptide binding]; other site 357809007734 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 357809007735 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357809007736 carboxyltransferase (CT) interaction site; other site 357809007737 biotinylation site [posttranslational modification]; other site 357809007738 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 357809007739 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 357809007740 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357809007741 recombination regulator RecX; Reviewed; Region: recX; PRK00117 357809007742 recombinase A; Provisional; Region: recA; PRK09354 357809007743 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 357809007744 hexamer interface [polypeptide binding]; other site 357809007745 Walker A motif; other site 357809007746 ATP binding site [chemical binding]; other site 357809007747 Walker B motif; other site 357809007748 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357809007749 threonine dehydratase; Provisional; Region: PRK08198 357809007750 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357809007751 tetramer interface [polypeptide binding]; other site 357809007752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809007753 catalytic residue [active] 357809007754 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 357809007755 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 357809007756 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 357809007757 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 357809007758 P loop; other site 357809007759 GTP binding site [chemical binding]; other site 357809007760 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 357809007761 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 357809007762 Walker A/P-loop; other site 357809007763 ATP binding site [chemical binding]; other site 357809007764 Q-loop/lid; other site 357809007765 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 357809007766 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 357809007767 ABC transporter signature motif; other site 357809007768 Walker B; other site 357809007769 D-loop; other site 357809007770 H-loop/switch region; other site 357809007771 ribonuclease III; Reviewed; Region: rnc; PRK00102 357809007772 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 357809007773 dimerization interface [polypeptide binding]; other site 357809007774 active site 357809007775 metal binding site [ion binding]; metal-binding site 357809007776 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 357809007777 dsRNA binding site [nucleotide binding]; other site 357809007778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809007779 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809007780 acyl carrier protein; Provisional; Region: acpP; PRK00982 357809007781 putative phosphate acyltransferase; Provisional; Region: PRK05331 357809007782 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 357809007783 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 357809007784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809007785 S-adenosylmethionine binding site [chemical binding]; other site 357809007786 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 357809007787 LytB protein; Region: LYTB; cl00507 357809007788 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 357809007789 RNA binding site [nucleotide binding]; other site 357809007790 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 357809007791 RNA binding site [nucleotide binding]; other site 357809007792 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 357809007793 RNA binding site [nucleotide binding]; other site 357809007794 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 357809007795 RNA binding site [nucleotide binding]; other site 357809007796 cytidylate kinase; Provisional; Region: cmk; PRK00023 357809007797 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 357809007798 CMP-binding site; other site 357809007799 The sites determining sugar specificity; other site 357809007800 HI0933-like protein; Region: HI0933_like; pfam03486 357809007801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809007802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809007803 Competence-damaged protein; Region: CinA; pfam02464 357809007804 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 357809007805 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 357809007806 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357809007807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809007808 FeS/SAM binding site; other site 357809007809 TRAM domain; Region: TRAM; cl01282 357809007810 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 357809007811 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 357809007812 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 357809007813 homodimer interface [polypeptide binding]; other site 357809007814 NADP binding site [chemical binding]; other site 357809007815 substrate binding site [chemical binding]; other site 357809007816 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 357809007817 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 357809007818 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 357809007819 putative active site [active] 357809007820 catalytic site [active] 357809007821 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 357809007822 putative active site [active] 357809007823 catalytic site [active] 357809007824 putative hydratase; Provisional; Region: PRK11413 357809007825 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 357809007826 substrate binding site [chemical binding]; other site 357809007827 ligand binding site [chemical binding]; other site 357809007828 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 357809007829 substrate binding site [chemical binding]; other site 357809007830 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809007831 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809007832 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809007833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809007834 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809007835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809007836 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 357809007837 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 357809007838 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 357809007839 dimer interface [polypeptide binding]; other site 357809007840 active site 357809007841 metal binding site [ion binding]; metal-binding site 357809007842 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809007843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007844 dimer interface [polypeptide binding]; other site 357809007845 conserved gate region; other site 357809007846 putative PBP binding loops; other site 357809007847 ABC-ATPase subunit interface; other site 357809007848 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357809007849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809007850 dimer interface [polypeptide binding]; other site 357809007851 conserved gate region; other site 357809007852 putative PBP binding loops; other site 357809007853 ABC-ATPase subunit interface; other site 357809007854 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357809007855 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809007856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809007857 DNA binding site [nucleotide binding] 357809007858 domain linker motif; other site 357809007859 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809007860 dimerization interface [polypeptide binding]; other site 357809007861 ligand binding site [chemical binding]; other site 357809007862 sporulation sigma factor SigG; Reviewed; Region: PRK08215 357809007863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809007864 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357809007865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809007866 DNA binding residues [nucleotide binding] 357809007867 sporulation sigma factor SigE; Reviewed; Region: PRK08301 357809007868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809007869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809007870 DNA binding residues [nucleotide binding] 357809007871 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 357809007872 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 357809007873 cell division protein FtsZ; Validated; Region: PRK09330 357809007874 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 357809007875 nucleotide binding site [chemical binding]; other site 357809007876 SulA interaction site; other site 357809007877 Cell division protein FtsQ; Region: FtsQ; pfam03799 357809007878 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 357809007879 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 357809007880 hinge; other site 357809007881 active site 357809007882 cell division protein FtsW; Region: ftsW; TIGR02614 357809007883 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 357809007884 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357809007885 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357809007886 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 357809007887 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357809007888 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357809007889 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 357809007890 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357809007891 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357809007892 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357809007893 Septum formation initiator; Region: DivIC; cl17659 357809007894 MraW methylase family; Region: Methyltransf_5; pfam01795 357809007895 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 357809007896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 357809007897 MraZ protein; Region: MraZ; pfam02381 357809007898 MraZ protein; Region: MraZ; pfam02381 357809007899 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 357809007900 GTP-binding protein YchF; Reviewed; Region: PRK09601 357809007901 YchF GTPase; Region: YchF; cd01900 357809007902 G1 box; other site 357809007903 GTP/Mg2+ binding site [chemical binding]; other site 357809007904 Switch I region; other site 357809007905 G2 box; other site 357809007906 Switch II region; other site 357809007907 G3 box; other site 357809007908 G4 box; other site 357809007909 G5 box; other site 357809007910 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 357809007911 Thiamine pyrophosphokinase; Region: TPK; cd07995 357809007912 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 357809007913 active site 357809007914 dimerization interface [polypeptide binding]; other site 357809007915 thiamine binding site [chemical binding]; other site 357809007916 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 357809007917 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 357809007918 substrate binding site [chemical binding]; other site 357809007919 hexamer interface [polypeptide binding]; other site 357809007920 metal binding site [ion binding]; metal-binding site 357809007921 GTPase RsgA; Reviewed; Region: PRK00098 357809007922 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 357809007923 RNA binding site [nucleotide binding]; other site 357809007924 homodimer interface [polypeptide binding]; other site 357809007925 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 357809007926 GTPase/Zn-binding domain interface [polypeptide binding]; other site 357809007927 GTP/Mg2+ binding site [chemical binding]; other site 357809007928 G4 box; other site 357809007929 G5 box; other site 357809007930 G1 box; other site 357809007931 Switch I region; other site 357809007932 G2 box; other site 357809007933 G3 box; other site 357809007934 Switch II region; other site 357809007935 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357809007936 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357809007937 active site 357809007938 ATP binding site [chemical binding]; other site 357809007939 substrate binding site [chemical binding]; other site 357809007940 activation loop (A-loop); other site 357809007941 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 357809007942 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 357809007943 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 357809007944 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 357809007945 active site 357809007946 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 357809007947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809007948 FeS/SAM binding site; other site 357809007949 16S rRNA methyltransferase B; Provisional; Region: PRK14902 357809007950 NusB family; Region: NusB; pfam01029 357809007951 putative RNA binding site [nucleotide binding]; other site 357809007952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809007953 S-adenosylmethionine binding site [chemical binding]; other site 357809007954 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 357809007955 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 357809007956 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 357809007957 putative active site [active] 357809007958 substrate binding site [chemical binding]; other site 357809007959 putative cosubstrate binding site; other site 357809007960 catalytic site [active] 357809007961 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 357809007962 substrate binding site [chemical binding]; other site 357809007963 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 357809007964 active site 357809007965 catalytic residues [active] 357809007966 metal binding site [ion binding]; metal-binding site 357809007967 primosome assembly protein PriA; Validated; Region: PRK05580 357809007968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809007969 ATP binding site [chemical binding]; other site 357809007970 putative Mg++ binding site [ion binding]; other site 357809007971 helicase superfamily c-terminal domain; Region: HELICc; smart00490 357809007972 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 357809007973 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357809007974 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357809007975 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357809007976 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 357809007977 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357809007978 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357809007979 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357809007980 glycogen synthase; Provisional; Region: glgA; PRK00654 357809007981 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 357809007982 ADP-binding pocket [chemical binding]; other site 357809007983 homodimer interface [polypeptide binding]; other site 357809007984 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 357809007985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809007986 active site 357809007987 phosphorylation site [posttranslational modification] 357809007988 intermolecular recognition site; other site 357809007989 dimerization interface [polypeptide binding]; other site 357809007990 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 357809007991 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 357809007992 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 357809007993 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 357809007994 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 357809007995 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 357809007996 Walker A/P-loop; other site 357809007997 ATP binding site [chemical binding]; other site 357809007998 Q-loop/lid; other site 357809007999 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 357809008000 ABC transporter signature motif; other site 357809008001 Walker B; other site 357809008002 D-loop; other site 357809008003 H-loop/switch region; other site 357809008004 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809008005 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 357809008006 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809008007 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809008008 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 357809008009 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809008010 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 357809008011 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809008012 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809008013 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 357809008014 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809008015 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809008016 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 357809008017 AAA domain; Region: AAA_18; pfam13238 357809008018 P-loop motif; other site 357809008019 ATP binding site [chemical binding]; other site 357809008020 Chloramphenicol (Cm) binding site [chemical binding]; other site 357809008021 catalytic residue [active] 357809008022 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357809008023 Double zinc ribbon; Region: DZR; pfam12773 357809008024 hypothetical protein; Validated; Region: PRK00110 357809008025 arginine repressor; Provisional; Region: argR; PRK00441 357809008026 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 357809008027 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 357809008028 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 357809008029 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 357809008030 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 357809008031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809008032 RNA binding surface [nucleotide binding]; other site 357809008033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809008034 S-adenosylmethionine binding site [chemical binding]; other site 357809008035 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 357809008036 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 357809008037 TPP-binding site; other site 357809008038 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 357809008039 PYR/PP interface [polypeptide binding]; other site 357809008040 dimer interface [polypeptide binding]; other site 357809008041 TPP binding site [chemical binding]; other site 357809008042 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357809008043 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 357809008044 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 357809008045 substrate binding pocket [chemical binding]; other site 357809008046 chain length determination region; other site 357809008047 substrate-Mg2+ binding site; other site 357809008048 catalytic residues [active] 357809008049 aspartate-rich region 1; other site 357809008050 active site lid residues [active] 357809008051 aspartate-rich region 2; other site 357809008052 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 357809008053 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 357809008054 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 357809008055 generic binding surface II; other site 357809008056 generic binding surface I; other site 357809008057 transcription antitermination factor NusB; Region: nusB; TIGR01951 357809008058 putative RNA binding site [nucleotide binding]; other site 357809008059 Asp23 family; Region: Asp23; pfam03780 357809008060 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 357809008061 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 357809008062 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 357809008063 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 357809008064 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 357809008065 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 357809008066 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 357809008067 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 357809008068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357809008069 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 357809008070 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 357809008071 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 357809008072 shikimate binding site; other site 357809008073 NAD(P) binding site [chemical binding]; other site 357809008074 Predicted transcriptional regulators [Transcription]; Region: COG1695 357809008075 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357809008076 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 357809008077 elongation factor P; Validated; Region: PRK00529 357809008078 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 357809008079 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 357809008080 RNA binding site [nucleotide binding]; other site 357809008081 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 357809008082 RNA binding site [nucleotide binding]; other site 357809008083 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 357809008084 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 357809008085 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 357809008086 active site 357809008087 Dehydroquinase class II; Region: DHquinase_II; pfam01220 357809008088 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 357809008089 trimer interface [polypeptide binding]; other site 357809008090 active site 357809008091 dimer interface [polypeptide binding]; other site 357809008092 shikimate kinase; Reviewed; Region: aroK; PRK00131 357809008093 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 357809008094 ADP binding site [chemical binding]; other site 357809008095 magnesium binding site [ion binding]; other site 357809008096 putative shikimate binding site; other site 357809008097 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 357809008098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809008099 active site 357809008100 motif I; other site 357809008101 motif II; other site 357809008102 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 357809008103 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 357809008104 NADP binding site [chemical binding]; other site 357809008105 homodimer interface [polypeptide binding]; other site 357809008106 active site 357809008107 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 357809008108 active site 357809008109 catalytic residues [active] 357809008110 Peptidase C26; Region: Peptidase_C26; pfam07722 357809008111 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 357809008112 catalytic triad [active] 357809008113 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 357809008114 elongation factor G; Reviewed; Region: PRK12740 357809008115 G1 box; other site 357809008116 putative GEF interaction site [polypeptide binding]; other site 357809008117 GTP/Mg2+ binding site [chemical binding]; other site 357809008118 Switch I region; other site 357809008119 G2 box; other site 357809008120 G3 box; other site 357809008121 Switch II region; other site 357809008122 G4 box; other site 357809008123 G5 box; other site 357809008124 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357809008125 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 357809008126 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 357809008127 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 357809008128 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 357809008129 prephenate dehydrogenase; Validated; Region: PRK06545 357809008130 prephenate dehydrogenase; Validated; Region: PRK08507 357809008131 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 357809008132 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 357809008133 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 357809008134 hinge; other site 357809008135 active site 357809008136 LysM domain; Region: LysM; pfam01476 357809008137 LexA repressor; Validated; Region: PRK00215 357809008138 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 357809008139 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 357809008140 Catalytic site [active] 357809008141 Oligomerisation domain; Region: Oligomerisation; pfam02410 357809008142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809008143 Zn2+ binding site [ion binding]; other site 357809008144 Mg2+ binding site [ion binding]; other site 357809008145 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 357809008146 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 357809008147 active site 357809008148 (T/H)XGH motif; other site 357809008149 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 357809008150 GTPase CgtA; Reviewed; Region: obgE; PRK12297 357809008151 GTP1/OBG; Region: GTP1_OBG; pfam01018 357809008152 Obg GTPase; Region: Obg; cd01898 357809008153 G1 box; other site 357809008154 GTP/Mg2+ binding site [chemical binding]; other site 357809008155 Switch I region; other site 357809008156 G2 box; other site 357809008157 G3 box; other site 357809008158 Switch II region; other site 357809008159 G4 box; other site 357809008160 G5 box; other site 357809008161 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 357809008162 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 357809008163 Protein of unknown function (DUF464); Region: DUF464; pfam04327 357809008164 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 357809008165 Protein of unknown function DUF45; Region: DUF45; pfam01863 357809008166 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 357809008167 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809008168 active site 357809008169 ATP binding site [chemical binding]; other site 357809008170 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809008171 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809008172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357809008173 MarR family; Region: MarR_2; pfam12802 357809008174 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809008175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809008176 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 357809008177 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 357809008178 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 357809008179 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 357809008180 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 357809008181 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357809008182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809008183 putative Zn2+ binding site [ion binding]; other site 357809008184 putative DNA binding site [nucleotide binding]; other site 357809008185 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 357809008186 putative deacylase active site [active] 357809008187 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 357809008188 homodimer interface [polypeptide binding]; other site 357809008189 oligonucleotide binding site [chemical binding]; other site 357809008190 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 357809008191 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 357809008192 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 357809008193 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 357809008194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 357809008195 FeS/SAM binding site; other site 357809008196 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 357809008197 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 357809008198 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 357809008199 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809008200 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 357809008201 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809008202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809008203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809008204 ABC-ATPase subunit interface; other site 357809008205 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809008206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809008207 dimer interface [polypeptide binding]; other site 357809008208 conserved gate region; other site 357809008209 ABC-ATPase subunit interface; other site 357809008210 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 357809008211 active site 357809008212 Glyco_18 domain; Region: Glyco_18; smart00636 357809008213 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 357809008214 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 357809008215 dimer interface [polypeptide binding]; other site 357809008216 putative anticodon binding site; other site 357809008217 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357809008218 motif 1; other site 357809008219 dimer interface [polypeptide binding]; other site 357809008220 active site 357809008221 motif 2; other site 357809008222 motif 3; other site 357809008223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809008224 Coenzyme A binding pocket [chemical binding]; other site 357809008225 Predicted acetyltransferase [General function prediction only]; Region: COG5628 357809008226 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 357809008227 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 357809008228 active site 357809008229 HIGH motif; other site 357809008230 dimer interface [polypeptide binding]; other site 357809008231 KMSKS motif; other site 357809008232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809008233 RNA binding surface [nucleotide binding]; other site 357809008234 SWIM zinc finger; Region: SWIM; pfam04434 357809008235 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 357809008236 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 357809008237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809008238 ATP binding site [chemical binding]; other site 357809008239 putative Mg++ binding site [ion binding]; other site 357809008240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809008241 nucleotide binding region [chemical binding]; other site 357809008242 ATP-binding site [chemical binding]; other site 357809008243 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 357809008244 putative transporter; Provisional; Region: PRK11660 357809008245 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357809008246 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 357809008247 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357809008248 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 357809008249 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 357809008250 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 357809008251 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 357809008252 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 357809008253 putative substrate binding region [chemical binding]; other site 357809008254 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 357809008255 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809008256 putative active site [active] 357809008257 putative metal binding site [ion binding]; other site 357809008258 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357809008259 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 357809008260 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 357809008261 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809008262 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809008263 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 357809008264 FtsX-like permease family; Region: FtsX; pfam02687 357809008265 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 357809008266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809008267 FtsX-like permease family; Region: FtsX; pfam02687 357809008268 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809008269 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809008270 Walker A/P-loop; other site 357809008271 ATP binding site [chemical binding]; other site 357809008272 Q-loop/lid; other site 357809008273 ABC transporter signature motif; other site 357809008274 Walker B; other site 357809008275 D-loop; other site 357809008276 H-loop/switch region; other site 357809008277 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 357809008278 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 357809008279 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 357809008280 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 357809008281 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 357809008282 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 357809008283 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357809008284 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 357809008285 active site 357809008286 DNA binding site [nucleotide binding] 357809008287 Int/Topo IB signature motif; other site 357809008288 Integral membrane protein DUF95; Region: DUF95; cl00572 357809008289 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 357809008290 dimer interface [polypeptide binding]; other site 357809008291 ADP-ribose binding site [chemical binding]; other site 357809008292 active site 357809008293 nudix motif; other site 357809008294 metal binding site [ion binding]; metal-binding site 357809008295 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809008296 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809008297 Helix-turn-helix domain; Region: HTH_38; pfam13936 357809008298 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 357809008299 phosphodiesterase; Provisional; Region: PRK12704 357809008300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809008301 Zn2+ binding site [ion binding]; other site 357809008302 Mg2+ binding site [ion binding]; other site 357809008303 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 357809008304 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357809008305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809008306 FeS/SAM binding site; other site 357809008307 TRAM domain; Region: TRAM; cl01282 357809008308 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 357809008309 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 357809008310 putative catalytic cysteine [active] 357809008311 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 357809008312 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 357809008313 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 357809008314 gamma-glutamyl kinase; Provisional; Region: PRK05429 357809008315 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 357809008316 nucleotide binding site [chemical binding]; other site 357809008317 homotetrameric interface [polypeptide binding]; other site 357809008318 putative phosphate binding site [ion binding]; other site 357809008319 putative allosteric binding site; other site 357809008320 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 357809008321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809008322 flavoprotein, HI0933 family; Region: TIGR00275 357809008323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809008324 stage V sporulation protein B; Region: spore_V_B; TIGR02900 357809008325 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 357809008326 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 357809008327 metal-binding heat shock protein; Provisional; Region: PRK00016 357809008328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 357809008329 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 357809008330 PhoH-like protein; Region: PhoH; pfam02562 357809008331 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 357809008332 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 357809008333 YabP family; Region: YabP; pfam07873 357809008334 Nitrogen regulatory protein P-II; Region: P-II; smart00938 357809008335 Nitrogen regulatory protein P-II; Region: P-II; cl00412 357809008336 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 357809008337 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 357809008338 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 357809008339 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 357809008340 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 357809008341 motif 1; other site 357809008342 active site 357809008343 motif 2; other site 357809008344 motif 3; other site 357809008345 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357809008346 DHHA1 domain; Region: DHHA1; pfam02272 357809008347 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 357809008348 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809008349 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809008350 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809008351 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 357809008352 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 357809008353 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 357809008354 generic binding surface II; other site 357809008355 generic binding surface I; other site 357809008356 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809008357 active site 357809008358 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 357809008359 active site 357809008360 catalytic site [active] 357809008361 substrate binding site [chemical binding]; other site 357809008362 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 357809008363 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 357809008364 GcpE protein; Region: GcpE; pfam04551 357809008365 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 357809008366 RIP metalloprotease RseP; Region: TIGR00054 357809008367 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 357809008368 active site 357809008369 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 357809008370 protein binding site [polypeptide binding]; other site 357809008371 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 357809008372 protein binding site [polypeptide binding]; other site 357809008373 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 357809008374 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 357809008375 putative substrate binding region [chemical binding]; other site 357809008376 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 357809008377 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 357809008378 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 357809008379 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 357809008380 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 357809008381 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 357809008382 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 357809008383 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 357809008384 catalytic residue [active] 357809008385 putative FPP diphosphate binding site; other site 357809008386 putative FPP binding hydrophobic cleft; other site 357809008387 dimer interface [polypeptide binding]; other site 357809008388 putative IPP diphosphate binding site; other site 357809008389 ribosome recycling factor; Reviewed; Region: frr; PRK00083 357809008390 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 357809008391 hinge region; other site 357809008392 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 357809008393 putative nucleotide binding site [chemical binding]; other site 357809008394 uridine monophosphate binding site [chemical binding]; other site 357809008395 homohexameric interface [polypeptide binding]; other site 357809008396 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 357809008397 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809008398 dimerization interface [polypeptide binding]; other site 357809008399 putative DNA binding site [nucleotide binding]; other site 357809008400 putative Zn2+ binding site [ion binding]; other site 357809008401 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 357809008402 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 357809008403 putative FMN binding site [chemical binding]; other site 357809008404 NADPH bind site [chemical binding]; other site 357809008405 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 357809008406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809008407 putative metal binding site [ion binding]; other site 357809008408 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 357809008409 active site 357809008410 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357809008411 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 357809008412 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 357809008413 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 357809008414 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 357809008415 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 357809008416 putative hexamer interface [polypeptide binding]; other site 357809008417 putative hexagonal pore; other site 357809008418 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 357809008419 putative hexamer interface [polypeptide binding]; other site 357809008420 putative hexagonal pore; other site 357809008421 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 357809008422 Hexamer/Pentamer interface [polypeptide binding]; other site 357809008423 central pore; other site 357809008424 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 357809008425 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 357809008426 Propanediol utilisation protein PduL; Region: PduL; pfam06130 357809008427 Propanediol utilisation protein PduL; Region: PduL; pfam06130 357809008428 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 357809008429 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809008430 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 357809008431 Hexamer interface [polypeptide binding]; other site 357809008432 Putative hexagonal pore residue; other site 357809008433 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 357809008434 putative catalytic cysteine [active] 357809008435 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 357809008436 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 357809008437 Hexamer interface [polypeptide binding]; other site 357809008438 Hexagonal pore residue; other site 357809008439 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 357809008440 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 357809008441 putative hexamer interface [polypeptide binding]; other site 357809008442 putative hexagonal pore; other site 357809008443 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 357809008444 putative hexamer interface [polypeptide binding]; other site 357809008445 putative hexagonal pore; other site 357809008446 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 357809008447 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 357809008448 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 357809008449 Ethanolamine utilisation protein EutA; Region: EutA; pfam06277 357809008450 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 357809008451 G1 box; other site 357809008452 GTP/Mg2+ binding site [chemical binding]; other site 357809008453 G2 box; other site 357809008454 Switch I region; other site 357809008455 G3 box; other site 357809008456 Switch II region; other site 357809008457 G4 box; other site 357809008458 G5 box; other site 357809008459 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 357809008460 putative hexamer interface [polypeptide binding]; other site 357809008461 putative hexagonal pore; other site 357809008462 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 357809008463 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 357809008464 putative active site [active] 357809008465 metal binding site [ion binding]; metal-binding site 357809008466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357809008467 catalytic core [active] 357809008468 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809008469 Helix-turn-helix domain; Region: HTH_18; pfam12833 357809008470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809008471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809008472 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809008473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809008474 dimer interface [polypeptide binding]; other site 357809008475 conserved gate region; other site 357809008476 putative PBP binding loops; other site 357809008477 ABC-ATPase subunit interface; other site 357809008478 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 357809008479 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809008480 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809008481 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357809008482 active site 357809008483 catalytic tetrad [active] 357809008484 Domain of unknown function (DUF303); Region: DUF303; pfam03629 357809008485 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357809008486 Domain of unknown function (DUF303); Region: DUF303; pfam03629 357809008487 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 357809008488 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 357809008489 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 357809008490 active site 357809008491 catalytic residues [active] 357809008492 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357809008493 MarR family; Region: MarR; pfam01047 357809008494 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 357809008495 catalytic residues [active] 357809008496 dimer interface [polypeptide binding]; other site 357809008497 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 357809008498 catalytic residues [active] 357809008499 dimer interface [polypeptide binding]; other site 357809008500 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 357809008501 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 357809008502 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 357809008503 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 357809008504 active site 357809008505 dimer interface [polypeptide binding]; other site 357809008506 motif 1; other site 357809008507 motif 2; other site 357809008508 motif 3; other site 357809008509 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 357809008510 anticodon binding site; other site 357809008511 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 357809008512 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357809008513 intersubunit interface [polypeptide binding]; other site 357809008514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809008515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809008516 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 357809008517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357809008518 substrate binding pocket [chemical binding]; other site 357809008519 membrane-bound complex binding site; other site 357809008520 hinge residues; other site 357809008521 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357809008522 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357809008523 Walker A/P-loop; other site 357809008524 ATP binding site [chemical binding]; other site 357809008525 Q-loop/lid; other site 357809008526 ABC transporter signature motif; other site 357809008527 Walker B; other site 357809008528 D-loop; other site 357809008529 H-loop/switch region; other site 357809008530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809008531 dimer interface [polypeptide binding]; other site 357809008532 conserved gate region; other site 357809008533 ABC-ATPase subunit interface; other site 357809008534 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357809008535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809008536 dimer interface [polypeptide binding]; other site 357809008537 conserved gate region; other site 357809008538 putative PBP binding loops; other site 357809008539 ABC-ATPase subunit interface; other site 357809008540 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 357809008541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809008542 Walker A/P-loop; other site 357809008543 ATP binding site [chemical binding]; other site 357809008544 Q-loop/lid; other site 357809008545 ABC transporter signature motif; other site 357809008546 Walker B; other site 357809008547 D-loop; other site 357809008548 H-loop/switch region; other site 357809008549 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 357809008550 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 357809008551 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 357809008552 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 357809008553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809008554 FeS/SAM binding site; other site 357809008555 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 357809008556 elongation factor Ts; Provisional; Region: tsf; PRK09377 357809008557 UBA/TS-N domain; Region: UBA; pfam00627 357809008558 Elongation factor TS; Region: EF_TS; pfam00889 357809008559 Elongation factor TS; Region: EF_TS; pfam00889 357809008560 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 357809008561 rRNA interaction site [nucleotide binding]; other site 357809008562 S8 interaction site; other site 357809008563 putative laminin-1 binding site; other site 357809008564 YceG-like family; Region: YceG; pfam02618 357809008565 Protein of unknown function (DUF342); Region: DUF342; pfam03961 357809008566 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 357809008567 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 357809008568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809008569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809008570 DNA binding residues [nucleotide binding] 357809008571 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 357809008572 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 357809008573 CheC-like family; Region: CheC; pfam04509 357809008574 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 357809008575 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 357809008576 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 357809008577 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 357809008578 putative binding surface; other site 357809008579 active site 357809008580 P2 response regulator binding domain; Region: P2; pfam07194 357809008581 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 357809008582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809008583 ATP binding site [chemical binding]; other site 357809008584 Mg2+ binding site [ion binding]; other site 357809008585 G-X-G motif; other site 357809008586 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 357809008587 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 357809008588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809008589 active site 357809008590 phosphorylation site [posttranslational modification] 357809008591 intermolecular recognition site; other site 357809008592 dimerization interface [polypeptide binding]; other site 357809008593 CheB methylesterase; Region: CheB_methylest; pfam01339 357809008594 PilZ domain; Region: PilZ; pfam07238 357809008595 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 357809008596 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 357809008597 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 357809008598 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809008599 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 357809008600 FHIPEP family; Region: FHIPEP; pfam00771 357809008601 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 357809008602 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 357809008603 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 357809008604 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 357809008605 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 357809008606 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 357809008607 Response regulator receiver domain; Region: Response_reg; pfam00072 357809008608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809008609 active site 357809008610 phosphorylation site [posttranslational modification] 357809008611 intermolecular recognition site; other site 357809008612 dimerization interface [polypeptide binding]; other site 357809008613 flagellar motor switch protein; Validated; Region: PRK08119 357809008614 CheC-like family; Region: CheC; pfam04509 357809008615 CheC-like family; Region: CheC; pfam04509 357809008616 flagellar motor switch protein FliN; Region: fliN; TIGR02480 357809008617 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 357809008618 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 357809008619 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 357809008620 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 357809008621 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357809008622 ligand binding site [chemical binding]; other site 357809008623 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 357809008624 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 357809008625 Flagellar protein (FlbD); Region: FlbD; pfam06289 357809008626 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 357809008627 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357809008628 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357809008629 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 357809008630 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 357809008631 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 357809008632 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 357809008633 Uncharacterized conserved protein [Function unknown]; Region: COG3334 357809008634 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 357809008635 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 357809008636 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 357809008637 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357809008638 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 357809008639 Walker A motif/ATP binding site; other site 357809008640 Walker B motif; other site 357809008641 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 357809008642 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 357809008643 Flagellar assembly protein FliH; Region: FliH; pfam02108 357809008644 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 357809008645 FliG C-terminal domain; Region: FliG_C; pfam01706 357809008646 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 357809008647 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 357809008648 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 357809008649 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 357809008650 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357809008651 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357809008652 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 357809008653 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 357809008654 transcriptional repressor CodY; Validated; Region: PRK04158 357809008655 CodY GAF-like domain; Region: CodY; pfam06018 357809008656 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 357809008657 DNA topoisomerase I; Validated; Region: PRK05582 357809008658 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 357809008659 active site 357809008660 interdomain interaction site; other site 357809008661 putative metal-binding site [ion binding]; other site 357809008662 nucleotide binding site [chemical binding]; other site 357809008663 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 357809008664 domain I; other site 357809008665 DNA binding groove [nucleotide binding] 357809008666 phosphate binding site [ion binding]; other site 357809008667 domain II; other site 357809008668 domain III; other site 357809008669 nucleotide binding site [chemical binding]; other site 357809008670 catalytic site [active] 357809008671 domain IV; other site 357809008672 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 357809008673 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 357809008674 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 357809008675 DNA protecting protein DprA; Region: dprA; TIGR00732 357809008676 RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127 357809008677 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 357809008678 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 357809008679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809008680 Walker A motif; other site 357809008681 ATP binding site [chemical binding]; other site 357809008682 Walker B motif; other site 357809008683 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 357809008684 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 357809008685 ATP cone domain; Region: ATP-cone; pfam03477 357809008686 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 357809008687 DNA polymerase IV; Reviewed; Region: PRK03103 357809008688 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 357809008689 active site 357809008690 DNA binding site [nucleotide binding] 357809008691 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 357809008692 Helix-turn-helix domain; Region: HTH_38; pfam13936 357809008693 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 357809008694 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357809008695 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 357809008696 Metal-binding active site; metal-binding site 357809008697 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 357809008698 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809008699 putative active site [active] 357809008700 putative metal binding site [ion binding]; other site 357809008701 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809008702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809008703 conserved gate region; other site 357809008704 dimer interface [polypeptide binding]; other site 357809008705 ABC-ATPase subunit interface; other site 357809008706 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809008707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809008708 dimer interface [polypeptide binding]; other site 357809008709 conserved gate region; other site 357809008710 putative PBP binding loops; other site 357809008711 ABC-ATPase subunit interface; other site 357809008712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809008713 Helix-turn-helix domain; Region: HTH_18; pfam12833 357809008714 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 357809008715 active site 357809008716 catalytic triad [active] 357809008717 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 357809008718 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 357809008719 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 357809008720 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 357809008721 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357809008722 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357809008723 substrate binding site [chemical binding]; other site 357809008724 ATP binding site [chemical binding]; other site 357809008725 galactarate dehydratase; Region: galactar-dH20; TIGR03248 357809008726 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 357809008727 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 357809008728 altronate oxidoreductase; Provisional; Region: PRK03643 357809008729 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 357809008730 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 357809008731 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809008732 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809008733 DNA binding site [nucleotide binding] 357809008734 domain linker motif; other site 357809008735 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809008736 dimerization interface [polypeptide binding]; other site 357809008737 ligand binding site [chemical binding]; other site 357809008738 Glucuronate isomerase; Region: UxaC; pfam02614 357809008739 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 357809008740 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357809008741 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 357809008742 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357809008743 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357809008744 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 357809008745 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 357809008746 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 357809008747 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 357809008748 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 357809008749 Potassium binding sites [ion binding]; other site 357809008750 Cesium cation binding sites [ion binding]; other site 357809008751 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 357809008752 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357809008753 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 357809008754 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357809008755 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357809008756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809008757 Coenzyme A binding pocket [chemical binding]; other site 357809008758 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 357809008759 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 357809008760 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357809008761 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 357809008762 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 357809008763 Clp protease; Region: CLP_protease; pfam00574 357809008764 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 357809008765 active site 357809008766 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 357809008767 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357809008768 homodimer interface [polypeptide binding]; other site 357809008769 substrate-cofactor binding pocket; other site 357809008770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809008771 catalytic residue [active] 357809008772 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 357809008773 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 357809008774 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 357809008775 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 357809008776 HPr interaction site; other site 357809008777 glycerol kinase (GK) interaction site [polypeptide binding]; other site 357809008778 active site 357809008779 phosphorylation site [posttranslational modification] 357809008780 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 357809008781 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 357809008782 RNase E interface [polypeptide binding]; other site 357809008783 trimer interface [polypeptide binding]; other site 357809008784 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 357809008785 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 357809008786 RNase E interface [polypeptide binding]; other site 357809008787 trimer interface [polypeptide binding]; other site 357809008788 active site 357809008789 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 357809008790 putative nucleic acid binding region [nucleotide binding]; other site 357809008791 G-X-X-G motif; other site 357809008792 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 357809008793 RNA binding site [nucleotide binding]; other site 357809008794 domain interface; other site 357809008795 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 357809008796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357809008797 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357809008798 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 357809008799 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809008800 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 357809008801 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 357809008802 16S/18S rRNA binding site [nucleotide binding]; other site 357809008803 S13e-L30e interaction site [polypeptide binding]; other site 357809008804 25S rRNA binding site [nucleotide binding]; other site 357809008805 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 357809008806 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 357809008807 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 357809008808 PhoU domain; Region: PhoU; pfam01895 357809008809 PhoU domain; Region: PhoU; pfam01895 357809008810 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357809008811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809008812 DNA-binding site [nucleotide binding]; DNA binding site 357809008813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809008814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809008815 homodimer interface [polypeptide binding]; other site 357809008816 catalytic residue [active] 357809008817 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 357809008818 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 357809008819 active site 357809008820 Riboflavin kinase; Region: Flavokinase; pfam01687 357809008821 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 357809008822 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 357809008823 RNA binding site [nucleotide binding]; other site 357809008824 active site 357809008825 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 357809008826 DHH family; Region: DHH; pfam01368 357809008827 DHHA1 domain; Region: DHHA1; pfam02272 357809008828 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 357809008829 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 357809008830 Invertebrate innate immunity transcript family; Region: Innate_immun; pfam12782 357809008831 translation initiation factor IF-2; Region: IF-2; TIGR00487 357809008832 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 357809008833 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 357809008834 G1 box; other site 357809008835 putative GEF interaction site [polypeptide binding]; other site 357809008836 GTP/Mg2+ binding site [chemical binding]; other site 357809008837 Switch I region; other site 357809008838 G2 box; other site 357809008839 G3 box; other site 357809008840 Switch II region; other site 357809008841 G4 box; other site 357809008842 G5 box; other site 357809008843 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 357809008844 Translation-initiation factor 2; Region: IF-2; pfam11987 357809008845 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 357809008846 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 357809008847 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 357809008848 putative RNA binding cleft [nucleotide binding]; other site 357809008849 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 357809008850 NusA N-terminal domain; Region: NusA_N; pfam08529 357809008851 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 357809008852 RNA binding site [nucleotide binding]; other site 357809008853 homodimer interface [polypeptide binding]; other site 357809008854 NusA-like KH domain; Region: KH_5; pfam13184 357809008855 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 357809008856 G-X-X-G motif; other site 357809008857 ribosome maturation protein RimP; Reviewed; Region: PRK00092 357809008858 Sm and related proteins; Region: Sm_like; cl00259 357809008859 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 357809008860 putative oligomer interface [polypeptide binding]; other site 357809008861 putative RNA binding site [nucleotide binding]; other site 357809008862 Biotin operon repressor [Transcription]; Region: BirA; COG1654 357809008863 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 357809008864 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 357809008865 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 357809008866 Rubrerythrin [Energy production and conversion]; Region: COG1592 357809008867 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 357809008868 binuclear metal center [ion binding]; other site 357809008869 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 357809008870 iron binding site [ion binding]; other site 357809008871 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 357809008872 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357809008873 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 357809008874 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 357809008875 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 357809008876 metal binding site [ion binding]; metal-binding site 357809008877 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 357809008878 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 357809008879 catalytic residues [active] 357809008880 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 357809008881 putative active site pocket [active] 357809008882 4-fold oligomerization interface [polypeptide binding]; other site 357809008883 metal binding residues [ion binding]; metal-binding site 357809008884 3-fold/trimer interface [polypeptide binding]; other site 357809008885 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 357809008886 histidinol dehydrogenase; Region: hisD; TIGR00069 357809008887 NAD binding site [chemical binding]; other site 357809008888 dimerization interface [polypeptide binding]; other site 357809008889 product binding site; other site 357809008890 substrate binding site [chemical binding]; other site 357809008891 zinc binding site [ion binding]; other site 357809008892 catalytic residues [active] 357809008893 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 357809008894 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 357809008895 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 357809008896 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357809008897 dimer interface [polypeptide binding]; other site 357809008898 motif 1; other site 357809008899 active site 357809008900 motif 2; other site 357809008901 motif 3; other site 357809008902 Recombination protein U; Region: RecU; cl01314 357809008903 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 357809008904 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809008905 RNA binding surface [nucleotide binding]; other site 357809008906 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357809008907 active site 357809008908 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 357809008909 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 357809008910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809008911 motif II; other site 357809008912 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 357809008913 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809008914 RNA binding surface [nucleotide binding]; other site 357809008915 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 357809008916 active site 357809008917 uracil binding [chemical binding]; other site 357809008918 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 357809008919 FtsJ-like methyltransferase; Region: FtsJ; cl17430 357809008920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809008921 S-adenosylmethionine binding site [chemical binding]; other site 357809008922 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 357809008923 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357809008924 synthetase active site [active] 357809008925 NTP binding site [chemical binding]; other site 357809008926 metal binding site [ion binding]; metal-binding site 357809008927 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 357809008928 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 357809008929 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 357809008930 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 357809008931 metal binding site [ion binding]; metal-binding site 357809008932 dimer interface [polypeptide binding]; other site 357809008933 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 357809008934 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 357809008935 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 357809008936 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 357809008937 GAF domain; Region: GAF; pfam01590 357809008938 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809008939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809008940 metal binding site [ion binding]; metal-binding site 357809008941 active site 357809008942 I-site; other site 357809008943 Cell division protein FtsA; Region: FtsA; smart00842 357809008944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 357809008945 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 357809008946 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 357809008947 CoA-binding site [chemical binding]; other site 357809008948 ATP-binding [chemical binding]; other site 357809008949 DNA polymerase I; Provisional; Region: PRK05755 357809008950 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 357809008951 active site 357809008952 metal binding site 1 [ion binding]; metal-binding site 357809008953 putative 5' ssDNA interaction site; other site 357809008954 metal binding site 3; metal-binding site 357809008955 metal binding site 2 [ion binding]; metal-binding site 357809008956 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 357809008957 putative DNA binding site [nucleotide binding]; other site 357809008958 putative metal binding site [ion binding]; other site 357809008959 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 357809008960 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 357809008961 active site 357809008962 DNA binding site [nucleotide binding] 357809008963 catalytic site [active] 357809008964 Putative zinc-finger; Region: zf-HC2; pfam13490 357809008965 YmaF family; Region: YmaF; pfam12788 357809008966 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357809008967 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357809008968 Probable Catalytic site; other site 357809008969 metal-binding site 357809008970 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 357809008971 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 357809008972 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 357809008973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809008974 active site 357809008975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357809008976 TPR motif; other site 357809008977 binding surface 357809008978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809008979 binding surface 357809008980 TPR motif; other site 357809008981 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 357809008982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809008983 binding surface 357809008984 TPR motif; other site 357809008985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357809008986 binding surface 357809008987 TPR motif; other site 357809008988 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 357809008989 putative ADP-binding pocket [chemical binding]; other site 357809008990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809008991 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 357809008992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809008993 putative ADP-binding pocket [chemical binding]; other site 357809008994 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 357809008995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809008996 putative ADP-binding pocket [chemical binding]; other site 357809008997 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357809008998 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357809008999 Probable Catalytic site; other site 357809009000 metal-binding site 357809009001 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357809009002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809009003 S-adenosylmethionine binding site [chemical binding]; other site 357809009004 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 357809009005 Uncharacterized conserved protein [Function unknown]; Region: COG1633 357809009006 dinuclear metal binding motif [ion binding]; other site 357809009007 YmaF family; Region: YmaF; pfam12788 357809009008 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809009009 active site 357809009010 catalytic triad [active] 357809009011 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 357809009012 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 357809009013 active site 357809009014 metal binding site [ion binding]; metal-binding site 357809009015 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 357809009016 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 357809009017 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 357809009018 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 357809009019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809009020 FeS/SAM binding site; other site 357809009021 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 357809009022 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 357809009023 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 357809009024 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 357809009025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 357809009026 Domain of unknown function (DUF1846); Region: DUF1846; pfam08903 357809009027 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 357809009028 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 357809009029 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 357809009030 PhoU domain; Region: PhoU; pfam01895 357809009031 PhoU domain; Region: PhoU; pfam01895 357809009032 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 357809009033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809009034 dimer interface [polypeptide binding]; other site 357809009035 phosphorylation site [posttranslational modification] 357809009036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809009037 ATP binding site [chemical binding]; other site 357809009038 Mg2+ binding site [ion binding]; other site 357809009039 G-X-G motif; other site 357809009040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809009041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009042 active site 357809009043 phosphorylation site [posttranslational modification] 357809009044 intermolecular recognition site; other site 357809009045 dimerization interface [polypeptide binding]; other site 357809009046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809009047 DNA binding site [nucleotide binding] 357809009048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809009049 Zn2+ binding site [ion binding]; other site 357809009050 Mg2+ binding site [ion binding]; other site 357809009051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809009052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809009053 dimer interface [polypeptide binding]; other site 357809009054 phosphorylation site [posttranslational modification] 357809009055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809009056 ATP binding site [chemical binding]; other site 357809009057 Mg2+ binding site [ion binding]; other site 357809009058 G-X-G motif; other site 357809009059 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 357809009060 PhoU domain; Region: PhoU; pfam01895 357809009061 PhoU domain; Region: PhoU; pfam01895 357809009062 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 357809009063 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 357809009064 Walker A/P-loop; other site 357809009065 ATP binding site [chemical binding]; other site 357809009066 Q-loop/lid; other site 357809009067 ABC transporter signature motif; other site 357809009068 Walker B; other site 357809009069 D-loop; other site 357809009070 H-loop/switch region; other site 357809009071 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 357809009072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809009073 dimer interface [polypeptide binding]; other site 357809009074 conserved gate region; other site 357809009075 putative PBP binding loops; other site 357809009076 ABC-ATPase subunit interface; other site 357809009077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809009078 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 357809009079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809009080 dimer interface [polypeptide binding]; other site 357809009081 conserved gate region; other site 357809009082 putative PBP binding loops; other site 357809009083 ABC-ATPase subunit interface; other site 357809009084 PBP superfamily domain; Region: PBP_like_2; cl17296 357809009085 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357809009086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809009087 metal binding site [ion binding]; metal-binding site 357809009088 active site 357809009089 I-site; other site 357809009090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357809009091 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809009092 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809009093 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809009094 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 357809009095 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 357809009096 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 357809009097 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 357809009098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 357809009099 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 357809009100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 357809009101 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357809009102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809009103 dimer interface [polypeptide binding]; other site 357809009104 phosphorylation site [posttranslational modification] 357809009105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809009106 ATP binding site [chemical binding]; other site 357809009107 Mg2+ binding site [ion binding]; other site 357809009108 G-X-G motif; other site 357809009109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009110 Response regulator receiver domain; Region: Response_reg; pfam00072 357809009111 active site 357809009112 phosphorylation site [posttranslational modification] 357809009113 intermolecular recognition site; other site 357809009114 dimerization interface [polypeptide binding]; other site 357809009115 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 357809009116 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 357809009117 ligand binding site [chemical binding]; other site 357809009118 active site 357809009119 UGI interface [polypeptide binding]; other site 357809009120 catalytic site [active] 357809009121 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 357809009122 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 357809009123 substrate binding site [chemical binding]; other site 357809009124 glutamase interaction surface [polypeptide binding]; other site 357809009125 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 357809009126 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 357809009127 putative active site [active] 357809009128 oxyanion strand; other site 357809009129 catalytic triad [active] 357809009130 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 357809009131 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357809009132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009133 active site 357809009134 phosphorylation site [posttranslational modification] 357809009135 intermolecular recognition site; other site 357809009136 dimerization interface [polypeptide binding]; other site 357809009137 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357809009138 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809009139 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809009140 catalytic residue [active] 357809009141 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 357809009142 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 357809009143 hybrid cluster protein; Provisional; Region: PRK05290 357809009144 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809009145 ACS interaction site; other site 357809009146 CODH interaction site; other site 357809009147 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 357809009148 hybrid metal cluster; other site 357809009149 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 357809009150 hybrid cluster protein; Provisional; Region: PRK05290 357809009151 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809009152 ACS interaction site; other site 357809009153 CODH interaction site; other site 357809009154 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809009155 ACS interaction site; other site 357809009156 CODH interaction site; other site 357809009157 metal cluster binding site [ion binding]; other site 357809009158 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 357809009159 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 357809009160 NAD binding site [chemical binding]; other site 357809009161 sugar binding site [chemical binding]; other site 357809009162 divalent metal binding site [ion binding]; other site 357809009163 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 357809009164 dimer interface [polypeptide binding]; other site 357809009165 NlpC/P60 family; Region: NLPC_P60; cl17555 357809009166 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357809009167 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 357809009168 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 357809009169 Bacterial PH domain; Region: DUF304; pfam03703 357809009170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809009171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809009172 dimerization interface [polypeptide binding]; other site 357809009173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809009174 dimer interface [polypeptide binding]; other site 357809009175 phosphorylation site [posttranslational modification] 357809009176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809009177 ATP binding site [chemical binding]; other site 357809009178 Mg2+ binding site [ion binding]; other site 357809009179 G-X-G motif; other site 357809009180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809009181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009182 active site 357809009183 phosphorylation site [posttranslational modification] 357809009184 intermolecular recognition site; other site 357809009185 dimerization interface [polypeptide binding]; other site 357809009186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809009187 DNA binding site [nucleotide binding] 357809009188 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 357809009189 active site 357809009190 thymidine kinase; Provisional; Region: PRK04296 357809009191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809009192 non-specific DNA binding site [nucleotide binding]; other site 357809009193 salt bridge; other site 357809009194 sequence-specific DNA binding site [nucleotide binding]; other site 357809009195 Response regulator receiver domain; Region: Response_reg; pfam00072 357809009196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009197 active site 357809009198 phosphorylation site [posttranslational modification] 357809009199 intermolecular recognition site; other site 357809009200 dimerization interface [polypeptide binding]; other site 357809009201 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357809009202 DNA-binding site [nucleotide binding]; DNA binding site 357809009203 RNA-binding motif; other site 357809009204 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 357809009205 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 357809009206 DRTGG domain; Region: DRTGG; pfam07085 357809009207 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357809009208 DHHA2 domain; Region: DHHA2; pfam02833 357809009209 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 357809009210 SmpB-tmRNA interface; other site 357809009211 ribonuclease R; Region: RNase_R; TIGR02063 357809009212 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 357809009213 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 357809009214 RNB domain; Region: RNB; pfam00773 357809009215 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 357809009216 RNA binding site [nucleotide binding]; other site 357809009217 Preprotein translocase SecG subunit; Region: SecG; pfam03840 357809009218 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 357809009219 phosphoglyceromutase; Provisional; Region: PRK05434 357809009220 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 357809009221 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809009222 Predicted membrane protein [Function unknown]; Region: COG2510 357809009223 Predicted membrane protein [Function unknown]; Region: COG2510 357809009224 triosephosphate isomerase; Provisional; Region: PRK14567 357809009225 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 357809009226 substrate binding site [chemical binding]; other site 357809009227 dimer interface [polypeptide binding]; other site 357809009228 catalytic triad [active] 357809009229 Phosphoglycerate kinase; Region: PGK; pfam00162 357809009230 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 357809009231 substrate binding site [chemical binding]; other site 357809009232 hinge regions; other site 357809009233 ADP binding site [chemical binding]; other site 357809009234 catalytic site [active] 357809009235 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 357809009236 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 357809009237 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 357809009238 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 357809009239 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357809009240 Catalytic site [active] 357809009241 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 357809009242 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357809009243 Catalytic site [active] 357809009244 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 357809009245 hypothetical protein; Provisional; Region: PRK04323 357809009246 hypothetical protein; Provisional; Region: PRK11820 357809009247 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 357809009248 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 357809009249 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809009250 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 357809009251 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357809009252 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 357809009253 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 357809009254 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 357809009255 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 357809009256 putative active site [active] 357809009257 catalytic site [active] 357809009258 putative metal binding site [ion binding]; other site 357809009259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809009260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357809009261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809009262 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 357809009263 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 357809009264 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357809009265 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 357809009266 Ligand binding site; other site 357809009267 Putative Catalytic site; other site 357809009268 DXD motif; other site 357809009269 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 357809009270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809009271 UDP-galactopyranose mutase; Region: GLF; pfam03275 357809009272 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 357809009273 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 357809009274 ssDNA binding site; other site 357809009275 generic binding surface II; other site 357809009276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809009277 ATP binding site [chemical binding]; other site 357809009278 putative Mg++ binding site [ion binding]; other site 357809009279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809009280 nucleotide binding region [chemical binding]; other site 357809009281 ATP-binding site [chemical binding]; other site 357809009282 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 357809009283 DAK2 domain; Region: Dak2; pfam02734 357809009284 Asp23 family; Region: Asp23; pfam03780 357809009285 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 357809009286 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579 357809009287 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 357809009288 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809009289 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809009290 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809009291 pyruvate kinase; Provisional; Region: PRK05826 357809009292 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 357809009293 domain interfaces; other site 357809009294 active site 357809009295 Rhomboid family; Region: Rhomboid; cl11446 357809009296 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 357809009297 Domain of unknown function (DUF814); Region: DUF814; pfam05670 357809009298 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809009299 histidinol-phosphatase; Provisional; Region: PRK05588 357809009300 active site 357809009301 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 357809009302 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 357809009303 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 357809009304 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 357809009305 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 357809009306 trimerization site [polypeptide binding]; other site 357809009307 active site 357809009308 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 357809009309 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 357809009310 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809009311 catalytic residue [active] 357809009312 stage V sporulation protein B; Region: spore_V_B; TIGR02900 357809009313 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 357809009314 Cytochrome P450; Region: p450; cl12078 357809009315 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 357809009316 Cytochrome P450; Region: p450; cl12078 357809009317 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357809009318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809009319 non-specific DNA binding site [nucleotide binding]; other site 357809009320 salt bridge; other site 357809009321 sequence-specific DNA binding site [nucleotide binding]; other site 357809009322 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 357809009323 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 357809009324 non-heme iron binding site [ion binding]; other site 357809009325 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 357809009326 GIY-YIG motif/motif A; other site 357809009327 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 357809009328 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 357809009329 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 357809009330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809009331 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 357809009332 Protein of unknown function (DUF419); Region: DUF419; pfam04237 357809009333 phosphoinositide phospholipase C 2; Region: PLN02222 357809009334 Right handed beta helix region; Region: Beta_helix; pfam13229 357809009335 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 357809009336 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 357809009337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357809009338 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 357809009339 ATP binding site [chemical binding]; other site 357809009340 putative Mg++ binding site [ion binding]; other site 357809009341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809009342 nucleotide binding region [chemical binding]; other site 357809009343 ATP-binding site [chemical binding]; other site 357809009344 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 357809009345 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 357809009346 cofactor binding site; other site 357809009347 DNA binding site [nucleotide binding] 357809009348 substrate interaction site [chemical binding]; other site 357809009349 Homoserine O-succinyltransferase; Region: HTS; pfam04204 357809009350 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 357809009351 proposed active site lysine [active] 357809009352 conserved cys residue [active] 357809009353 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 357809009354 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 357809009355 nucleotide binding pocket [chemical binding]; other site 357809009356 K-X-D-G motif; other site 357809009357 catalytic site [active] 357809009358 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 357809009359 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 357809009360 Dimer interface [polypeptide binding]; other site 357809009361 BRCT sequence motif; other site 357809009362 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 357809009363 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809009364 RNA binding surface [nucleotide binding]; other site 357809009365 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 357809009366 probable active site [active] 357809009367 Nucleoporin FG repeat region; Region: Nucleoporin_FG; pfam13634 357809009368 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809009369 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809009370 metal binding site [ion binding]; metal-binding site 357809009371 active site 357809009372 I-site; other site 357809009373 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357809009374 putative oxidoreductase; Provisional; Region: PRK12831 357809009375 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809009376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809009377 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 357809009378 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 357809009379 FAD binding pocket [chemical binding]; other site 357809009380 FAD binding motif [chemical binding]; other site 357809009381 phosphate binding motif [ion binding]; other site 357809009382 beta-alpha-beta structure motif; other site 357809009383 NAD binding pocket [chemical binding]; other site 357809009384 Iron coordination center [ion binding]; other site 357809009385 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357809009386 active site 357809009387 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 357809009388 dimer interface [polypeptide binding]; other site 357809009389 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357809009390 Ligand Binding Site [chemical binding]; other site 357809009391 Molecular Tunnel; other site 357809009392 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 357809009393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809009394 ATP binding site [chemical binding]; other site 357809009395 Mg2+ binding site [ion binding]; other site 357809009396 G-X-G motif; other site 357809009397 Response regulator receiver domain; Region: Response_reg; pfam00072 357809009398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009399 active site 357809009400 phosphorylation site [posttranslational modification] 357809009401 intermolecular recognition site; other site 357809009402 dimerization interface [polypeptide binding]; other site 357809009403 LytTr DNA-binding domain; Region: LytTR; pfam04397 357809009404 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357809009405 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 357809009406 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 357809009407 MFS/sugar transport protein; Region: MFS_2; pfam13347 357809009408 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 357809009409 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809009410 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 357809009411 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809009412 NlpC/P60 family; Region: NLPC_P60; cl17555 357809009413 Holin family; Region: Phage_holin_4; pfam05105 357809009414 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 357809009415 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 357809009416 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 357809009417 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 357809009418 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809009419 Phage XkdN-like protein; Region: XkdN; pfam08890 357809009420 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 357809009421 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 357809009422 fructose-bisphosphate aldolase; Region: PLN02858 357809009423 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 357809009424 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 357809009425 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 357809009426 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 357809009427 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 357809009428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 357809009429 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 357809009430 Homeodomain-like domain; Region: HTH_23; pfam13384 357809009431 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 357809009432 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357809009433 Domain of unknown function (DUF927); Region: DUF927; cl12098 357809009434 CHC2 zinc finger; Region: zf-CHC2; cl17510 357809009435 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 357809009436 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357809009437 dimer interface [polypeptide binding]; other site 357809009438 ssDNA binding site [nucleotide binding]; other site 357809009439 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357809009440 ERF superfamily; Region: ERF; pfam04404 357809009441 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 357809009442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809009443 Zn2+ binding site [ion binding]; other site 357809009444 Mg2+ binding site [ion binding]; other site 357809009445 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 357809009446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 357809009447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357809009448 non-specific DNA binding site [nucleotide binding]; other site 357809009449 salt bridge; other site 357809009450 sequence-specific DNA binding site [nucleotide binding]; other site 357809009451 Domain of unknown function (DUF955); Region: DUF955; cl01076 357809009452 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 357809009453 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 357809009454 catalytic residues [active] 357809009455 catalytic nucleophile [active] 357809009456 Recombinase; Region: Recombinase; pfam07508 357809009457 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 357809009458 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809009459 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357809009460 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 357809009461 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357809009462 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809009463 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 357809009464 active site 357809009465 hypothetical protein; Provisional; Region: PRK13690 357809009466 enolase; Provisional; Region: eno; PRK00077 357809009467 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 357809009468 dimer interface [polypeptide binding]; other site 357809009469 metal binding site [ion binding]; metal-binding site 357809009470 substrate binding pocket [chemical binding]; other site 357809009471 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809009472 Bacterial SH3 domain homologues; Region: SH3b; smart00287 357809009473 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 357809009474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809009475 Coenzyme A binding pocket [chemical binding]; other site 357809009476 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 357809009477 FOG: CBS domain [General function prediction only]; Region: COG0517 357809009478 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357809009479 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 357809009480 argininosuccinate lyase; Provisional; Region: PRK00855 357809009481 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 357809009482 active sites [active] 357809009483 tetramer interface [polypeptide binding]; other site 357809009484 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357809009485 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809009486 Walker A/P-loop; other site 357809009487 ATP binding site [chemical binding]; other site 357809009488 Q-loop/lid; other site 357809009489 ABC transporter signature motif; other site 357809009490 Walker B; other site 357809009491 D-loop; other site 357809009492 H-loop/switch region; other site 357809009493 Probable beta-xylosidase; Provisional; Region: PLN03080 357809009494 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357809009495 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357809009496 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 357809009497 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 357809009498 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 357809009499 inhibitor binding site; inhibition site 357809009500 active site 357809009501 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 357809009502 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 357809009503 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 357809009504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809009505 Walker A/P-loop; other site 357809009506 ATP binding site [chemical binding]; other site 357809009507 Q-loop/lid; other site 357809009508 ABC transporter signature motif; other site 357809009509 Walker B; other site 357809009510 D-loop; other site 357809009511 H-loop/switch region; other site 357809009512 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357809009513 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357809009514 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 357809009515 Domain of unknown function DUF21; Region: DUF21; pfam01595 357809009516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357809009517 Transporter associated domain; Region: CorC_HlyC; smart01091 357809009518 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 357809009519 MgtE intracellular N domain; Region: MgtE_N; pfam03448 357809009520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 357809009521 Divalent cation transporter; Region: MgtE; pfam01769 357809009522 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 357809009523 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 357809009524 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 357809009525 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 357809009526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809009527 DNA binding residues [nucleotide binding] 357809009528 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809009529 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809009530 ketol-acid reductoisomerase; Provisional; Region: PRK05479 357809009531 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 357809009532 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 357809009533 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 357809009534 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 357809009535 putative valine binding site [chemical binding]; other site 357809009536 dimer interface [polypeptide binding]; other site 357809009537 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 357809009538 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 357809009539 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 357809009540 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 357809009541 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809009542 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357809009543 active site 357809009544 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 357809009545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809009546 putative substrate translocation pore; other site 357809009547 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809009548 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357809009549 active site 357809009550 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809009551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809009552 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 357809009553 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 357809009554 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 357809009555 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 357809009556 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 357809009557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809009558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809009559 dimer interface [polypeptide binding]; other site 357809009560 conserved gate region; other site 357809009561 putative PBP binding loops; other site 357809009562 ABC-ATPase subunit interface; other site 357809009563 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809009564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809009565 dimer interface [polypeptide binding]; other site 357809009566 conserved gate region; other site 357809009567 putative PBP binding loops; other site 357809009568 ABC-ATPase subunit interface; other site 357809009569 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809009570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809009571 dimerization interface [polypeptide binding]; other site 357809009572 Histidine kinase; Region: His_kinase; pfam06580 357809009573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809009574 ATP binding site [chemical binding]; other site 357809009575 Mg2+ binding site [ion binding]; other site 357809009576 G-X-G motif; other site 357809009577 Response regulator receiver domain; Region: Response_reg; pfam00072 357809009578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009579 active site 357809009580 phosphorylation site [posttranslational modification] 357809009581 intermolecular recognition site; other site 357809009582 dimerization interface [polypeptide binding]; other site 357809009583 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809009584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809009585 FMN-binding domain; Region: FMN_bind; pfam04205 357809009586 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 357809009587 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 357809009588 ApbE family; Region: ApbE; pfam02424 357809009589 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 357809009590 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 357809009591 GDP-binding site [chemical binding]; other site 357809009592 ACT binding site; other site 357809009593 IMP binding site; other site 357809009594 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 357809009595 trimer interface [polypeptide binding]; other site 357809009596 active site 357809009597 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 357809009598 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 357809009599 oligomer interface [polypeptide binding]; other site 357809009600 putative active site [active] 357809009601 metal binding site [ion binding]; metal-binding site 357809009602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809009603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809009604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809009605 dimerization interface [polypeptide binding]; other site 357809009606 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 357809009607 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 357809009608 NAD(P) binding site [chemical binding]; other site 357809009609 catalytic residues [active] 357809009610 hypothetical protein; Validated; Region: PRK00124 357809009611 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 357809009612 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 357809009613 tetramer interface [polypeptide binding]; other site 357809009614 active site 357809009615 amidophosphoribosyltransferase; Provisional; Region: PRK05793 357809009616 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 357809009617 active site 357809009618 tetramer interface [polypeptide binding]; other site 357809009619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809009620 active site 357809009621 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 357809009622 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 357809009623 ATP binding site [chemical binding]; other site 357809009624 active site 357809009625 substrate binding site [chemical binding]; other site 357809009626 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 357809009627 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 357809009628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809009629 FeS/SAM binding site; other site 357809009630 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809009631 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 357809009632 DNA binding residues [nucleotide binding] 357809009633 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 357809009634 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 357809009635 ATP cone domain; Region: ATP-cone; pfam03477 357809009636 Class III ribonucleotide reductase; Region: RNR_III; cd01675 357809009637 effector binding site; other site 357809009638 active site 357809009639 Zn binding site [ion binding]; other site 357809009640 glycine loop; other site 357809009641 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 357809009642 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 357809009643 dimer interface [polypeptide binding]; other site 357809009644 active site 357809009645 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357809009646 catalytic residues [active] 357809009647 substrate binding site [chemical binding]; other site 357809009648 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 357809009649 agmatinase; Region: agmatinase; TIGR01230 357809009650 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 357809009651 putative active site [active] 357809009652 Mn binding site [ion binding]; other site 357809009653 spermidine synthase; Provisional; Region: PRK00811 357809009654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809009655 S-adenosylmethionine binding site [chemical binding]; other site 357809009656 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 357809009657 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 357809009658 homodimer interface [polypeptide binding]; other site 357809009659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809009660 catalytic residue [active] 357809009661 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 357809009662 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 357809009663 Melibiase; Region: Melibiase; pfam02065 357809009664 FOG: CBS domain [General function prediction only]; Region: COG0517 357809009665 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 357809009666 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 357809009667 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 357809009668 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 357809009669 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 357809009670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357809009671 active site 357809009672 catalytic tetrad [active] 357809009673 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809009674 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 357809009675 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 357809009676 active site 357809009677 catalytic triad [active] 357809009678 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809009679 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809009680 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357809009681 Peptidase family M23; Region: Peptidase_M23; pfam01551 357809009682 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809009683 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 357809009684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809009685 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 357809009686 Walker A/P-loop; other site 357809009687 ATP binding site [chemical binding]; other site 357809009688 Q-loop/lid; other site 357809009689 ABC transporter signature motif; other site 357809009690 Walker B; other site 357809009691 D-loop; other site 357809009692 H-loop/switch region; other site 357809009693 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809009694 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 357809009695 Walker A/P-loop; other site 357809009696 ATP binding site [chemical binding]; other site 357809009697 Q-loop/lid; other site 357809009698 ABC transporter signature motif; other site 357809009699 Walker B; other site 357809009700 D-loop; other site 357809009701 H-loop/switch region; other site 357809009702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357809009703 dimerization interface [polypeptide binding]; other site 357809009704 putative DNA binding site [nucleotide binding]; other site 357809009705 putative Zn2+ binding site [ion binding]; other site 357809009706 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 357809009707 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 357809009708 NodB motif; other site 357809009709 active site 357809009710 catalytic site [active] 357809009711 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 357809009712 V-type ATP synthase subunit B; Provisional; Region: PRK04196 357809009713 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357809009714 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 357809009715 Walker A motif homologous position; other site 357809009716 Walker B motif; other site 357809009717 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357809009718 V-type ATP synthase subunit A; Provisional; Region: PRK04192 357809009719 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357809009720 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 357809009721 Walker A motif/ATP binding site; other site 357809009722 Walker B motif; other site 357809009723 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357809009724 V-type ATP synthase subunit F; Provisional; Region: PRK01395 357809009725 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 357809009726 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 357809009727 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 357809009728 V-type ATP synthase subunit K; Validated; Region: PRK06558 357809009729 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 357809009730 V-type ATP synthase subunit I; Validated; Region: PRK05771 357809009731 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 357809009732 trimer interface [polypeptide binding]; other site 357809009733 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357809009734 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357809009735 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 357809009736 ACT domain-containing protein [General function prediction only]; Region: COG4747 357809009737 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 357809009738 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 357809009739 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 357809009740 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357809009741 acyl-activating enzyme (AAE) consensus motif; other site 357809009742 AMP binding site [chemical binding]; other site 357809009743 active site 357809009744 CoA binding site [chemical binding]; other site 357809009745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 357809009746 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 357809009747 Probable transposase; Region: OrfB_IS605; pfam01385 357809009748 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 357809009749 ACT domain-containing protein [General function prediction only]; Region: COG4747 357809009750 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 357809009751 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 357809009752 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 357809009753 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 357809009754 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 357809009755 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357809009756 dimer interface [polypeptide binding]; other site 357809009757 PYR/PP interface [polypeptide binding]; other site 357809009758 TPP binding site [chemical binding]; other site 357809009759 substrate binding site [chemical binding]; other site 357809009760 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 357809009761 TPP-binding site; other site 357809009762 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 357809009763 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 357809009764 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 357809009765 Na binding site [ion binding]; other site 357809009766 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 357809009767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357809009768 acyl-activating enzyme (AAE) consensus motif; other site 357809009769 AMP binding site [chemical binding]; other site 357809009770 active site 357809009771 CoA binding site [chemical binding]; other site 357809009772 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 357809009773 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 357809009774 Tetramer interface [polypeptide binding]; other site 357809009775 active site 357809009776 FMN-binding site [chemical binding]; other site 357809009777 HAMP domain; Region: HAMP; pfam00672 357809009778 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809009779 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809009780 dimer interface [polypeptide binding]; other site 357809009781 putative CheW interface [polypeptide binding]; other site 357809009782 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357809009783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809009784 DNA-binding site [nucleotide binding]; DNA binding site 357809009785 FCD domain; Region: FCD; pfam07729 357809009786 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 357809009787 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 357809009788 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 357809009789 active site 357809009790 catalytic residues [active] 357809009791 metal binding site [ion binding]; metal-binding site 357809009792 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357809009793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809009794 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809009795 DNA binding residues [nucleotide binding] 357809009796 Putative zinc-finger; Region: zf-HC2; pfam13490 357809009797 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 357809009798 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 357809009799 active site 357809009800 dimer interfaces [polypeptide binding]; other site 357809009801 catalytic residues [active] 357809009802 carbamate kinase; Reviewed; Region: PRK12686 357809009803 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 357809009804 putative substrate binding site [chemical binding]; other site 357809009805 nucleotide binding site [chemical binding]; other site 357809009806 nucleotide binding site [chemical binding]; other site 357809009807 homodimer interface [polypeptide binding]; other site 357809009808 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357809009809 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 357809009810 Probable Catalytic site; other site 357809009811 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 357809009812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809009813 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 357809009814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809009815 Walker A/P-loop; other site 357809009816 ATP binding site [chemical binding]; other site 357809009817 Q-loop/lid; other site 357809009818 ABC transporter signature motif; other site 357809009819 Walker B; other site 357809009820 D-loop; other site 357809009821 H-loop/switch region; other site 357809009822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 357809009823 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357809009824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357809009825 Walker A/P-loop; other site 357809009826 ATP binding site [chemical binding]; other site 357809009827 Q-loop/lid; other site 357809009828 ABC transporter signature motif; other site 357809009829 Walker B; other site 357809009830 D-loop; other site 357809009831 H-loop/switch region; other site 357809009832 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357809009833 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 357809009834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809009835 dimer interface [polypeptide binding]; other site 357809009836 conserved gate region; other site 357809009837 putative PBP binding loops; other site 357809009838 ABC-ATPase subunit interface; other site 357809009839 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357809009840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357809009841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809009842 dimer interface [polypeptide binding]; other site 357809009843 conserved gate region; other site 357809009844 putative PBP binding loops; other site 357809009845 ABC-ATPase subunit interface; other site 357809009846 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 357809009847 peptide binding site [polypeptide binding]; other site 357809009848 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 357809009849 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 357809009850 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 357809009851 active site 357809009852 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 357809009853 FAD binding site [chemical binding]; other site 357809009854 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 357809009855 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 357809009856 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 357809009857 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 357809009858 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 357809009859 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 357809009860 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 357809009861 FMN binding site [chemical binding]; other site 357809009862 substrate binding site [chemical binding]; other site 357809009863 putative catalytic residue [active] 357809009864 phosphoglycolate phosphatase; Provisional; Region: PRK13222 357809009865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809009866 motif II; other site 357809009867 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809009868 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 357809009869 Walker A/P-loop; other site 357809009870 ATP binding site [chemical binding]; other site 357809009871 Q-loop/lid; other site 357809009872 ABC transporter signature motif; other site 357809009873 Walker B; other site 357809009874 D-loop; other site 357809009875 H-loop/switch region; other site 357809009876 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809009877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809009878 Walker A/P-loop; other site 357809009879 ATP binding site [chemical binding]; other site 357809009880 Q-loop/lid; other site 357809009881 ABC transporter signature motif; other site 357809009882 Walker B; other site 357809009883 D-loop; other site 357809009884 H-loop/switch region; other site 357809009885 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357809009886 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 357809009887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809009888 active site 357809009889 phosphorylation site [posttranslational modification] 357809009890 intermolecular recognition site; other site 357809009891 dimerization interface [polypeptide binding]; other site 357809009892 LytTr DNA-binding domain; Region: LytTR; smart00850 357809009893 AAA domain; Region: AAA_21; pfam13304 357809009894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809009895 Walker A/P-loop; other site 357809009896 ATP binding site [chemical binding]; other site 357809009897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809009898 Walker B; other site 357809009899 D-loop; other site 357809009900 H-loop/switch region; other site 357809009901 Rubrerythrin [Energy production and conversion]; Region: COG1592 357809009902 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 357809009903 binuclear metal center [ion binding]; other site 357809009904 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 357809009905 iron binding site [ion binding]; other site 357809009906 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 357809009907 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 357809009908 TPP-binding site [chemical binding]; other site 357809009909 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 357809009910 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 357809009911 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 357809009912 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357809009913 dimer interface [polypeptide binding]; other site 357809009914 PYR/PP interface [polypeptide binding]; other site 357809009915 TPP binding site [chemical binding]; other site 357809009916 substrate binding site [chemical binding]; other site 357809009917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809009918 Coenzyme A binding pocket [chemical binding]; other site 357809009919 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809009920 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357809009921 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 357809009922 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809009923 active site 357809009924 metal binding site [ion binding]; metal-binding site 357809009925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357809009926 active site 357809009927 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 357809009928 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 357809009929 TIGR04076 family protein; Region: TIGR04076 357809009930 Helix-turn-helix domain; Region: HTH_18; pfam12833 357809009931 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 357809009932 nudix motif; other site 357809009933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 357809009934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809009935 Coenzyme A binding pocket [chemical binding]; other site 357809009936 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 357809009937 nudix motif; other site 357809009938 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 357809009939 dimer interface [polypeptide binding]; other site 357809009940 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809009941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 357809009942 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 357809009943 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809009944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809009945 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 357809009946 adenosine deaminase; Provisional; Region: PRK09358 357809009947 active site 357809009948 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 357809009949 DNA binding site [nucleotide binding] 357809009950 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 357809009951 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 357809009952 active site 357809009953 catalytic residues [active] 357809009954 DNA binding site [nucleotide binding] 357809009955 Int/Topo IB signature motif; other site 357809009956 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357809009957 homotrimer interaction site [polypeptide binding]; other site 357809009958 putative active site [active] 357809009959 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 357809009960 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 357809009961 putative active site [active] 357809009962 putative NTP binding site [chemical binding]; other site 357809009963 putative nucleic acid binding site [nucleotide binding]; other site 357809009964 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 357809009965 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357809009966 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357809009967 ligand binding site [chemical binding]; other site 357809009968 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 357809009969 Ferredoxin [Energy production and conversion]; Region: COG1146 357809009970 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 357809009971 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 357809009972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809009973 S-adenosylmethionine binding site [chemical binding]; other site 357809009974 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 357809009975 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 357809009976 N- and C-terminal domain interface [polypeptide binding]; other site 357809009977 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 357809009978 active site 357809009979 putative catalytic site [active] 357809009980 metal binding site [ion binding]; metal-binding site 357809009981 ATP binding site [chemical binding]; other site 357809009982 carbohydrate binding site [chemical binding]; other site 357809009983 L-fucose isomerase; Provisional; Region: fucI; PRK10991 357809009984 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 357809009985 hexamer (dimer of trimers) interface [polypeptide binding]; other site 357809009986 trimer interface [polypeptide binding]; other site 357809009987 substrate binding site [chemical binding]; other site 357809009988 Mn binding site [ion binding]; other site 357809009989 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809009990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809009991 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809009992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809009993 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 357809009994 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 357809009995 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 357809009996 Cupin domain; Region: Cupin_2; pfam07883 357809009997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809009998 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809009999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010000 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 357809010001 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357809010002 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 357809010003 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 357809010004 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 357809010005 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809010006 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809010007 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 357809010008 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 357809010009 Predicted transcriptional regulators [Transcription]; Region: COG1695 357809010010 Transcriptional regulator PadR-like family; Region: PadR; cl17335 357809010011 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 357809010012 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 357809010013 AzlC protein; Region: AzlC; cl00570 357809010014 maltose O-acetyltransferase; Provisional; Region: PRK10092 357809010015 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 357809010016 active site 357809010017 substrate binding site [chemical binding]; other site 357809010018 trimer interface [polypeptide binding]; other site 357809010019 CoA binding site [chemical binding]; other site 357809010020 AAA domain; Region: AAA_21; pfam13304 357809010021 AAA domain; Region: AAA_21; pfam13304 357809010022 2-isopropylmalate synthase; Validated; Region: PRK00915 357809010023 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 357809010024 active site 357809010025 catalytic residues [active] 357809010026 metal binding site [ion binding]; metal-binding site 357809010027 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 357809010028 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 357809010029 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 357809010030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809010031 catalytic residue [active] 357809010032 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809010033 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809010034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809010035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 357809010036 putative transposase OrfB; Reviewed; Region: PHA02517 357809010037 HTH-like domain; Region: HTH_21; pfam13276 357809010038 Integrase core domain; Region: rve; pfam00665 357809010039 Integrase core domain; Region: rve_2; pfam13333 357809010040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 357809010041 Helix-turn-helix domain; Region: HTH_28; pfam13518 357809010042 Helix-turn-helix domain; Region: HTH_28; pfam13518 357809010043 Winged helix-turn helix; Region: HTH_29; pfam13551 357809010044 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 357809010045 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 357809010046 putative active site [active] 357809010047 substrate binding site [chemical binding]; other site 357809010048 putative cosubstrate binding site; other site 357809010049 catalytic site [active] 357809010050 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 357809010051 substrate binding site [chemical binding]; other site 357809010052 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 357809010053 dimer interface [polypeptide binding]; other site 357809010054 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809010055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809010056 S-adenosylmethionine binding site [chemical binding]; other site 357809010057 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357809010058 active site 357809010059 metal binding site [ion binding]; metal-binding site 357809010060 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809010061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010062 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 357809010063 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 357809010064 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 357809010065 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 357809010066 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 357809010067 putative dimer interface [polypeptide binding]; other site 357809010068 catalytic triad [active] 357809010069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809010070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809010071 Coenzyme A binding pocket [chemical binding]; other site 357809010072 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 357809010073 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357809010074 AAA domain; Region: AAA_17; pfam13207 357809010075 AAA domain; Region: AAA_33; pfam13671 357809010076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809010077 Coenzyme A binding pocket [chemical binding]; other site 357809010078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 357809010079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809010080 Coenzyme A binding pocket [chemical binding]; other site 357809010081 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809010082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809010083 S-adenosylmethionine binding site [chemical binding]; other site 357809010084 TM2 domain; Region: TM2; pfam05154 357809010085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809010086 Phosphotransferase enzyme family; Region: APH; pfam01636 357809010087 active site 357809010088 ATP binding site [chemical binding]; other site 357809010089 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 357809010090 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357809010091 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 357809010092 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 357809010093 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 357809010094 Cellulose binding domain; Region: CBM_2; pfam00553 357809010095 phosphodiesterase; Provisional; Region: PRK12704 357809010096 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 357809010097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809010098 Coenzyme A binding pocket [chemical binding]; other site 357809010099 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 357809010100 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 357809010101 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 357809010102 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357809010103 HAMP domain; Region: HAMP; pfam00672 357809010104 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809010105 dimer interface [polypeptide binding]; other site 357809010106 putative CheW interface [polypeptide binding]; other site 357809010107 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 357809010108 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809010109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010110 dimer interface [polypeptide binding]; other site 357809010111 conserved gate region; other site 357809010112 ABC-ATPase subunit interface; other site 357809010113 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809010114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010115 dimer interface [polypeptide binding]; other site 357809010116 conserved gate region; other site 357809010117 ABC-ATPase subunit interface; other site 357809010118 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809010119 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 357809010120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809010121 active site 357809010122 phosphorylation site [posttranslational modification] 357809010123 intermolecular recognition site; other site 357809010124 dimerization interface [polypeptide binding]; other site 357809010125 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809010126 Histidine kinase; Region: His_kinase; pfam06580 357809010127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809010128 ATP binding site [chemical binding]; other site 357809010129 Mg2+ binding site [ion binding]; other site 357809010130 G-X-G motif; other site 357809010131 Integrase core domain; Region: rve_2; pfam13333 357809010132 HTH-like domain; Region: HTH_21; pfam13276 357809010133 Integrase core domain; Region: rve; pfam00665 357809010134 Helix-turn-helix domain; Region: HTH_28; pfam13518 357809010135 Winged helix-turn helix; Region: HTH_29; pfam13551 357809010136 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 357809010137 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 357809010138 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 357809010139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357809010140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809010141 putative substrate translocation pore; other site 357809010142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 357809010143 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 357809010144 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 357809010145 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 357809010146 dimer interface [polypeptide binding]; other site 357809010147 putative radical transfer pathway; other site 357809010148 diiron center [ion binding]; other site 357809010149 tyrosyl radical; other site 357809010150 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 357809010151 ATP cone domain; Region: ATP-cone; pfam03477 357809010152 Class I ribonucleotide reductase; Region: RNR_I; cd01679 357809010153 active site 357809010154 dimer interface [polypeptide binding]; other site 357809010155 catalytic residues [active] 357809010156 effector binding site; other site 357809010157 R2 peptide binding site; other site 357809010158 Short C-terminal domain; Region: SHOCT; pfam09851 357809010159 Short C-terminal domain; Region: SHOCT; pfam09851 357809010160 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 357809010161 putative FMN binding site [chemical binding]; other site 357809010162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357809010163 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 357809010164 CAAX protease self-immunity; Region: Abi; pfam02517 357809010165 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809010166 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 357809010167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809010168 Coenzyme A binding pocket [chemical binding]; other site 357809010169 Putative zinc-finger; Region: zf-HC2; pfam13490 357809010170 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 357809010171 Creatinine amidohydrolase; Region: Creatininase; pfam02633 357809010172 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 357809010173 dimer interface [polypeptide binding]; other site 357809010174 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 357809010175 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 357809010176 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 357809010177 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 357809010178 putative active site [active] 357809010179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809010180 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809010181 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809010182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010183 dimer interface [polypeptide binding]; other site 357809010184 conserved gate region; other site 357809010185 putative PBP binding loops; other site 357809010186 ABC-ATPase subunit interface; other site 357809010187 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809010188 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 357809010189 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 357809010190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357809010191 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 357809010192 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357809010193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 357809010194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357809010195 Cupin domain; Region: Cupin_2; cl17218 357809010196 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809010197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809010198 Coenzyme A binding pocket [chemical binding]; other site 357809010199 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 357809010200 metal binding site [ion binding]; metal-binding site 357809010201 Nitroreductase family; Region: Nitroreductase; pfam00881 357809010202 FMN binding site [chemical binding]; other site 357809010203 dimer interface [polypeptide binding]; other site 357809010204 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 357809010205 dimer interface [polypeptide binding]; other site 357809010206 Cupin domain; Region: Cupin_2; pfam07883 357809010207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010208 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809010209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010210 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357809010211 Domain of unknown function DUF20; Region: UPF0118; pfam01594 357809010212 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 357809010213 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 357809010214 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 357809010215 substrate binding pocket [chemical binding]; other site 357809010216 dimer interface [polypeptide binding]; other site 357809010217 inhibitor binding site; inhibition site 357809010218 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 357809010219 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 357809010220 B12 binding site [chemical binding]; other site 357809010221 cobalt ligand [ion binding]; other site 357809010222 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809010223 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357809010224 active site 357809010225 metal binding site [ion binding]; metal-binding site 357809010226 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 357809010227 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 357809010228 GGGtGRT protein; Region: GGGtGRT; pfam14057 357809010229 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 357809010230 Acid Phosphatase; Region: Acid_PPase; cl17256 357809010231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809010232 motif II; other site 357809010233 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 357809010234 WxL domain surface cell wall-binding; Region: WxL; pfam13731 357809010235 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809010236 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809010237 TM-ABC transporter signature motif; other site 357809010238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809010239 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 357809010240 TM-ABC transporter signature motif; other site 357809010241 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 357809010242 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809010243 Walker A/P-loop; other site 357809010244 ATP binding site [chemical binding]; other site 357809010245 Q-loop/lid; other site 357809010246 ABC transporter signature motif; other site 357809010247 Walker B; other site 357809010248 D-loop; other site 357809010249 H-loop/switch region; other site 357809010250 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809010251 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 357809010252 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 357809010253 ligand binding site [chemical binding]; other site 357809010254 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 357809010255 DNA topoisomerase III; Provisional; Region: PRK07726 357809010256 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 357809010257 active site 357809010258 putative interdomain interaction site [polypeptide binding]; other site 357809010259 putative metal-binding site [ion binding]; other site 357809010260 putative nucleotide binding site [chemical binding]; other site 357809010261 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 357809010262 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 357809010263 domain II; other site 357809010264 domain III; other site 357809010265 nucleotide binding site [chemical binding]; other site 357809010266 DNA binding groove [nucleotide binding] 357809010267 catalytic site [active] 357809010268 domain IV; other site 357809010269 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 357809010270 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 357809010271 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 357809010272 dimer interface [polypeptide binding]; other site 357809010273 active site 357809010274 glycine-pyridoxal phosphate binding site [chemical binding]; other site 357809010275 folate binding site [chemical binding]; other site 357809010276 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809010277 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809010278 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809010279 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809010280 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 357809010281 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 357809010282 putative ligand binding site [chemical binding]; other site 357809010283 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809010284 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357809010285 TM-ABC transporter signature motif; other site 357809010286 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357809010287 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357809010288 Walker A/P-loop; other site 357809010289 ATP binding site [chemical binding]; other site 357809010290 Q-loop/lid; other site 357809010291 ABC transporter signature motif; other site 357809010292 Walker B; other site 357809010293 D-loop; other site 357809010294 H-loop/switch region; other site 357809010295 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357809010296 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357809010297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809010298 Walker A/P-loop; other site 357809010299 ATP binding site [chemical binding]; other site 357809010300 Q-loop/lid; other site 357809010301 ABC transporter signature motif; other site 357809010302 Walker B; other site 357809010303 D-loop; other site 357809010304 H-loop/switch region; other site 357809010305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809010306 Walker A/P-loop; other site 357809010307 ATP binding site [chemical binding]; other site 357809010308 Q-loop/lid; other site 357809010309 ABC transporter signature motif; other site 357809010310 Walker B; other site 357809010311 D-loop; other site 357809010312 H-loop/switch region; other site 357809010313 Histidine kinase; Region: His_kinase; pfam06580 357809010314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809010315 ATP binding site [chemical binding]; other site 357809010316 Mg2+ binding site [ion binding]; other site 357809010317 G-X-G motif; other site 357809010318 Response regulator receiver domain; Region: Response_reg; pfam00072 357809010319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809010320 active site 357809010321 phosphorylation site [posttranslational modification] 357809010322 intermolecular recognition site; other site 357809010323 dimerization interface [polypeptide binding]; other site 357809010324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809010326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010327 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 357809010328 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 357809010329 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 357809010330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809010331 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809010332 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 357809010333 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357809010334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 357809010335 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 357809010336 active site 357809010337 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 357809010338 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 357809010339 ring oligomerisation interface [polypeptide binding]; other site 357809010340 ATP/Mg binding site [chemical binding]; other site 357809010341 stacking interactions; other site 357809010342 hinge regions; other site 357809010343 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357809010344 oligomerisation interface [polypeptide binding]; other site 357809010345 mobile loop; other site 357809010346 roof hairpin; other site 357809010347 VanZ like family; Region: VanZ; pfam04892 357809010348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 357809010349 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 357809010350 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 357809010351 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357809010352 active site 357809010353 HIGH motif; other site 357809010354 nucleotide binding site [chemical binding]; other site 357809010355 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357809010356 active site 357809010357 KMSKS motif; other site 357809010358 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 357809010359 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 357809010360 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 357809010361 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 357809010362 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357809010363 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 357809010364 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 357809010365 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 357809010366 active site 357809010367 Zn binding site [ion binding]; other site 357809010368 FMN-binding domain; Region: FMN_bind; cl01081 357809010369 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 357809010370 L-aspartate oxidase; Provisional; Region: PRK06175 357809010371 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 357809010372 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 357809010373 putative active site [active] 357809010374 putative metal binding site [ion binding]; other site 357809010375 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 357809010376 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357809010377 catalytic core [active] 357809010378 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809010379 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 357809010380 DNA binding residues [nucleotide binding] 357809010381 dimer interface [polypeptide binding]; other site 357809010382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809010383 S-adenosylmethionine binding site [chemical binding]; other site 357809010384 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 357809010385 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 357809010386 NAD binding site [chemical binding]; other site 357809010387 substrate binding site [chemical binding]; other site 357809010388 homodimer interface [polypeptide binding]; other site 357809010389 active site 357809010390 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 357809010391 Uncharacterized conserved protein [Function unknown]; Region: COG1434 357809010392 putative active site [active] 357809010393 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 357809010394 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 357809010395 sugar binding site [chemical binding]; other site 357809010396 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 357809010397 beta-phosphoglucomutase; Region: bPGM; TIGR01990 357809010398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809010399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809010400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809010401 DNA binding site [nucleotide binding] 357809010402 domain linker motif; other site 357809010403 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809010404 dimerization interface [polypeptide binding]; other site 357809010405 ligand binding site [chemical binding]; other site 357809010406 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 357809010407 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 357809010408 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 357809010409 maltose phosphorylase; Provisional; Region: PRK13807 357809010410 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 357809010411 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 357809010412 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 357809010413 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809010414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010415 dimer interface [polypeptide binding]; other site 357809010416 conserved gate region; other site 357809010417 putative PBP binding loops; other site 357809010418 ABC-ATPase subunit interface; other site 357809010419 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357809010420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010421 dimer interface [polypeptide binding]; other site 357809010422 conserved gate region; other site 357809010423 putative PBP binding loops; other site 357809010424 ABC-ATPase subunit interface; other site 357809010425 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809010426 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809010427 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357809010428 MarR family; Region: MarR_2; pfam12802 357809010429 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 357809010430 putative efflux protein, MATE family; Region: matE; TIGR00797 357809010431 RNA polymerase factor sigma-70; Validated; Region: PRK08295 357809010432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809010433 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 357809010434 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 357809010435 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357809010436 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 357809010437 active site 357809010438 metal binding site [ion binding]; metal-binding site 357809010439 dimerization interface [polypeptide binding]; other site 357809010440 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 357809010441 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357809010442 active site 357809010443 HIGH motif; other site 357809010444 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357809010445 KMSKS motif; other site 357809010446 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 357809010447 tRNA binding surface [nucleotide binding]; other site 357809010448 anticodon binding site; other site 357809010449 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 357809010450 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 357809010451 trimer interface [polypeptide binding]; other site 357809010452 active site 357809010453 substrate binding site [chemical binding]; other site 357809010454 CoA binding site [chemical binding]; other site 357809010455 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 357809010456 homotrimer interaction site [polypeptide binding]; other site 357809010457 zinc binding site [ion binding]; other site 357809010458 CDP-binding sites; other site 357809010459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010460 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809010461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010462 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 357809010463 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357809010464 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 357809010465 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 357809010466 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357809010467 Mor transcription activator family; Region: Mor; cl02360 357809010468 FtsX-like permease family; Region: FtsX; pfam02687 357809010469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809010470 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809010471 Walker A/P-loop; other site 357809010472 ATP binding site [chemical binding]; other site 357809010473 Q-loop/lid; other site 357809010474 ABC transporter signature motif; other site 357809010475 Walker B; other site 357809010476 D-loop; other site 357809010477 H-loop/switch region; other site 357809010478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809010479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809010480 ATP binding site [chemical binding]; other site 357809010481 Mg2+ binding site [ion binding]; other site 357809010482 G-X-G motif; other site 357809010483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809010484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809010485 active site 357809010486 phosphorylation site [posttranslational modification] 357809010487 intermolecular recognition site; other site 357809010488 dimerization interface [polypeptide binding]; other site 357809010489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809010490 DNA binding site [nucleotide binding] 357809010491 Phosphotransferase enzyme family; Region: APH; pfam01636 357809010492 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 357809010493 active site 357809010494 substrate binding site [chemical binding]; other site 357809010495 ATP binding site [chemical binding]; other site 357809010496 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 357809010497 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 357809010498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809010499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357809010500 catalytic core [active] 357809010501 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 357809010502 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 357809010503 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 357809010504 putative active site [active] 357809010505 catalytic site [active] 357809010506 putative metal binding site [ion binding]; other site 357809010507 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 357809010508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809010509 motif II; other site 357809010510 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 357809010511 Predicted transcriptional regulator [Transcription]; Region: COG2378 357809010512 HTH domain; Region: HTH_11; pfam08279 357809010513 WYL domain; Region: WYL; pfam13280 357809010514 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357809010515 conserved cys residue [active] 357809010516 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809010517 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809010518 EDD domain protein, DegV family; Region: DegV; TIGR00762 357809010519 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 357809010520 6-phosphofructokinase; Provisional; Region: PRK14072 357809010521 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 357809010522 active site 357809010523 ADP/pyrophosphate binding site [chemical binding]; other site 357809010524 dimerization interface [polypeptide binding]; other site 357809010525 allosteric effector site; other site 357809010526 fructose-1,6-bisphosphate binding site; other site 357809010527 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 357809010528 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357809010529 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 357809010530 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357809010531 PYR/PP interface [polypeptide binding]; other site 357809010532 dimer interface [polypeptide binding]; other site 357809010533 TPP binding site [chemical binding]; other site 357809010534 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357809010535 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 357809010536 TPP-binding site [chemical binding]; other site 357809010537 dimer interface [polypeptide binding]; other site 357809010538 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 357809010539 peptidase T; Region: peptidase-T; TIGR01882 357809010540 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 357809010541 metal binding site [ion binding]; metal-binding site 357809010542 dimer interface [polypeptide binding]; other site 357809010543 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 357809010544 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 357809010545 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 357809010546 dimerization interface [polypeptide binding]; other site 357809010547 ATP binding site [chemical binding]; other site 357809010548 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 357809010549 dimerization interface [polypeptide binding]; other site 357809010550 ATP binding site [chemical binding]; other site 357809010551 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 357809010552 putative active site [active] 357809010553 catalytic triad [active] 357809010554 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 357809010555 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 357809010556 Mg++ binding site [ion binding]; other site 357809010557 putative catalytic motif [active] 357809010558 putative substrate binding site [chemical binding]; other site 357809010559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809010560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809010561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809010562 dimerization interface [polypeptide binding]; other site 357809010563 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 357809010564 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 357809010565 putative active site [active] 357809010566 Zn binding site [ion binding]; other site 357809010567 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 357809010568 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 357809010569 putative active site [active] 357809010570 Zn binding site [ion binding]; other site 357809010571 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 357809010572 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 357809010573 substrate binding site [chemical binding]; other site 357809010574 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 357809010575 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 357809010576 substrate binding site [chemical binding]; other site 357809010577 ligand binding site [chemical binding]; other site 357809010578 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 357809010579 tartrate dehydrogenase; Provisional; Region: PRK08194 357809010580 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 357809010581 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 357809010582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809010583 motif II; other site 357809010584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357809010585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357809010586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357809010587 dimerization interface [polypeptide binding]; other site 357809010588 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 357809010589 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357809010590 minor groove reading motif; other site 357809010591 helix-hairpin-helix signature motif; other site 357809010592 substrate binding pocket [chemical binding]; other site 357809010593 active site 357809010594 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 357809010595 DNA binding and oxoG recognition site [nucleotide binding] 357809010596 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357809010597 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809010598 Protein of unknown function DUF58; Region: DUF58; pfam01882 357809010599 MoxR-like ATPases [General function prediction only]; Region: COG0714 357809010600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809010601 Walker A motif; other site 357809010602 ATP binding site [chemical binding]; other site 357809010603 Walker B motif; other site 357809010604 arginine finger; other site 357809010605 endoglucanase; Region: PLN02420 357809010606 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 357809010607 Cellulose binding domain; Region: CBM_3; pfam00942 357809010608 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 357809010609 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 357809010610 Cellulose binding domain; Region: CBM_3; pfam00942 357809010611 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 357809010612 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 357809010613 Cellulose binding domain; Region: CBM_3; pfam00942 357809010614 heat shock protein 90; Provisional; Region: PRK05218 357809010615 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357809010616 ATP binding site [chemical binding]; other site 357809010617 Mg2+ binding site [ion binding]; other site 357809010618 G-X-G motif; other site 357809010619 TraX protein; Region: TraX; pfam05857 357809010620 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 357809010621 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809010622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809010623 ABC transporter; Region: ABC_tran_2; pfam12848 357809010624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809010625 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809010626 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 357809010627 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 357809010628 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 357809010629 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357809010630 Mechanosensitive ion channel; Region: MS_channel; pfam00924 357809010631 Protein of unknown function, DUF624; Region: DUF624; pfam04854 357809010632 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 357809010633 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 357809010634 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809010635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809010636 S-adenosylmethionine binding site [chemical binding]; other site 357809010637 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809010638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809010639 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809010640 Walker A/P-loop; other site 357809010641 ATP binding site [chemical binding]; other site 357809010642 Q-loop/lid; other site 357809010643 ABC transporter signature motif; other site 357809010644 Walker B; other site 357809010645 D-loop; other site 357809010646 H-loop/switch region; other site 357809010647 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809010648 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809010649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809010650 Walker A/P-loop; other site 357809010651 ATP binding site [chemical binding]; other site 357809010652 Q-loop/lid; other site 357809010653 ABC transporter signature motif; other site 357809010654 Walker B; other site 357809010655 D-loop; other site 357809010656 H-loop/switch region; other site 357809010657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357809010658 active site 357809010659 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 357809010660 putative ligand binding site [chemical binding]; other site 357809010661 putative NAD binding site [chemical binding]; other site 357809010662 putative catalytic site [active] 357809010663 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 357809010664 L-serine binding site [chemical binding]; other site 357809010665 ACT domain interface; other site 357809010666 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 357809010667 homodimer interface [polypeptide binding]; other site 357809010668 substrate-cofactor binding pocket; other site 357809010669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809010670 catalytic residue [active] 357809010671 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 357809010672 active site 357809010673 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 357809010674 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 357809010675 active site 357809010676 catalytic residues [active] 357809010677 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 357809010678 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 357809010679 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 357809010680 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 357809010681 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809010682 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 357809010683 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_3; cd08975 357809010684 putative DNA binding site [nucleotide binding]; other site 357809010685 catalytic residue [active] 357809010686 putative H2TH interface [polypeptide binding]; other site 357809010687 putative catalytic residues [active] 357809010688 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 357809010689 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357809010690 FAD binding domain; Region: FAD_binding_4; pfam01565 357809010691 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357809010692 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 357809010693 putative N- and C-terminal domain interface [polypeptide binding]; other site 357809010694 putative active site [active] 357809010695 MgATP binding site [chemical binding]; other site 357809010696 catalytic site [active] 357809010697 metal binding site [ion binding]; metal-binding site 357809010698 putative carbohydrate binding site [chemical binding]; other site 357809010699 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 357809010700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357809010701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809010702 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 357809010703 NAD(P) binding pocket [chemical binding]; other site 357809010704 Predicted dehydrogenase [General function prediction only]; Region: COG0579 357809010705 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357809010706 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357809010707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809010708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809010709 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 357809010710 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 357809010711 NAD(P) binding site [chemical binding]; other site 357809010712 LDH/MDH dimer interface [polypeptide binding]; other site 357809010713 substrate binding site [chemical binding]; other site 357809010714 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357809010715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809010716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010717 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 357809010718 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 357809010719 inhibitor binding site; inhibition site 357809010720 active site 357809010721 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 357809010722 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 357809010723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809010724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010725 dimer interface [polypeptide binding]; other site 357809010726 conserved gate region; other site 357809010727 putative PBP binding loops; other site 357809010728 ABC-ATPase subunit interface; other site 357809010729 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809010730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010731 dimer interface [polypeptide binding]; other site 357809010732 conserved gate region; other site 357809010733 putative PBP binding loops; other site 357809010734 ABC-ATPase subunit interface; other site 357809010735 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809010736 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809010737 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 357809010738 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 357809010739 Response regulator receiver domain; Region: Response_reg; pfam00072 357809010740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809010741 active site 357809010742 phosphorylation site [posttranslational modification] 357809010743 intermolecular recognition site; other site 357809010744 dimerization interface [polypeptide binding]; other site 357809010745 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809010746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809010747 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809010748 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809010749 dimerization interface [polypeptide binding]; other site 357809010750 Histidine kinase; Region: His_kinase; pfam06580 357809010751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809010752 ATP binding site [chemical binding]; other site 357809010753 Mg2+ binding site [ion binding]; other site 357809010754 G-X-G motif; other site 357809010755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809010756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010757 dimer interface [polypeptide binding]; other site 357809010758 conserved gate region; other site 357809010759 putative PBP binding loops; other site 357809010760 ABC-ATPase subunit interface; other site 357809010761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809010762 dimer interface [polypeptide binding]; other site 357809010763 conserved gate region; other site 357809010764 putative PBP binding loops; other site 357809010765 ABC-ATPase subunit interface; other site 357809010766 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809010767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809010768 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 357809010769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809010770 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 357809010771 active site 357809010772 homodimer interface [polypeptide binding]; other site 357809010773 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 357809010774 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 357809010775 glutaminase active site [active] 357809010776 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 357809010777 dimer interface [polypeptide binding]; other site 357809010778 active site 357809010779 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 357809010780 dimer interface [polypeptide binding]; other site 357809010781 active site 357809010782 FlxA-like protein; Region: FlxA; pfam14282 357809010783 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 357809010784 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 357809010785 putative active site [active] 357809010786 catalytic site [active] 357809010787 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 357809010788 putative active site [active] 357809010789 catalytic site [active] 357809010790 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 357809010791 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 357809010792 dimerization interface [polypeptide binding]; other site 357809010793 domain crossover interface; other site 357809010794 redox-dependent activation switch; other site 357809010795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809010796 S-adenosylmethionine binding site [chemical binding]; other site 357809010797 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 357809010798 N- and C-terminal domain interface [polypeptide binding]; other site 357809010799 D-xylulose kinase; Region: XylB; TIGR01312 357809010800 active site 357809010801 MgATP binding site [chemical binding]; other site 357809010802 catalytic site [active] 357809010803 metal binding site [ion binding]; metal-binding site 357809010804 xylulose binding site [chemical binding]; other site 357809010805 homodimer interface [polypeptide binding]; other site 357809010806 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357809010807 MarR family; Region: MarR_2; pfam12802 357809010808 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357809010809 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357809010810 nucleotide binding site [chemical binding]; other site 357809010811 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 357809010812 putative lipid kinase; Reviewed; Region: PRK13337 357809010813 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 357809010814 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 357809010815 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 357809010816 Part of AAA domain; Region: AAA_19; pfam13245 357809010817 Family description; Region: UvrD_C_2; pfam13538 357809010818 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 357809010819 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 357809010820 Cytoplasmic phospholipase A2, catalytic subunit; Region: PLAc; smart00022 357809010821 NAD synthetase; Reviewed; Region: nadE; PRK02628 357809010822 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 357809010823 multimer interface [polypeptide binding]; other site 357809010824 active site 357809010825 catalytic triad [active] 357809010826 protein interface 1 [polypeptide binding]; other site 357809010827 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 357809010828 homodimer interface [polypeptide binding]; other site 357809010829 NAD binding pocket [chemical binding]; other site 357809010830 ATP binding pocket [chemical binding]; other site 357809010831 Mg binding site [ion binding]; other site 357809010832 active-site loop [active] 357809010833 Radical SAM superfamily; Region: Radical_SAM; pfam04055 357809010834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809010835 FeS/SAM binding site; other site 357809010836 HAMP domain; Region: HAMP; pfam00672 357809010837 dimerization interface [polypeptide binding]; other site 357809010838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809010839 dimer interface [polypeptide binding]; other site 357809010840 phosphorylation site [posttranslational modification] 357809010841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809010842 ATP binding site [chemical binding]; other site 357809010843 Mg2+ binding site [ion binding]; other site 357809010844 G-X-G motif; other site 357809010845 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809010846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809010847 active site 357809010848 phosphorylation site [posttranslational modification] 357809010849 intermolecular recognition site; other site 357809010850 dimerization interface [polypeptide binding]; other site 357809010851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809010852 DNA binding site [nucleotide binding] 357809010853 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809010854 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 357809010855 DHHW protein; Region: DHHW; pfam14286 357809010856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809010857 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809010858 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 357809010859 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357809010860 active site 357809010861 metal binding site [ion binding]; metal-binding site 357809010862 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 357809010863 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 357809010864 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 357809010865 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 357809010866 active site 357809010867 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 357809010868 Preprotein translocase subunit; Region: YajC; pfam02699 357809010869 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 357809010870 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 357809010871 methionine aminopeptidase; Provisional; Region: PRK12318 357809010872 SEC-C motif; Region: SEC-C; pfam02810 357809010873 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 357809010874 active site 357809010875 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 357809010876 V-type ATP synthase subunit B; Provisional; Region: PRK04196 357809010877 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357809010878 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 357809010879 Walker A motif homologous position; other site 357809010880 Walker B motif; other site 357809010881 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357809010882 V-type ATP synthase subunit A; Provisional; Region: PRK04192 357809010883 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357809010884 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 357809010885 Walker A motif/ATP binding site; other site 357809010886 Walker B motif; other site 357809010887 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357809010888 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 357809010889 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 357809010890 V-type ATP synthase subunit I; Validated; Region: PRK05771 357809010891 Yip1 domain; Region: Yip1; pfam04893 357809010892 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 357809010893 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 357809010894 Domain of unknown function (DUF4220); Region: DUF4220; pfam13968 357809010895 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 357809010896 asparagine synthetase AsnA; Provisional; Region: PRK05425 357809010897 motif 1; other site 357809010898 dimer interface [polypeptide binding]; other site 357809010899 active site 357809010900 motif 2; other site 357809010901 motif 3; other site 357809010902 Cache domain; Region: Cache_1; pfam02743 357809010903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809010904 dimerization interface [polypeptide binding]; other site 357809010905 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809010906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809010907 dimer interface [polypeptide binding]; other site 357809010908 putative CheW interface [polypeptide binding]; other site 357809010909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357809010910 active site 357809010911 DNA binding site [nucleotide binding] 357809010912 Int/Topo IB signature motif; other site 357809010913 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809010914 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 357809010915 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 357809010916 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 357809010917 HAMP domain; Region: HAMP; pfam00672 357809010918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809010919 dimer interface [polypeptide binding]; other site 357809010920 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357809010921 putative CheW interface [polypeptide binding]; other site 357809010922 PQQ-like domain; Region: PQQ_2; pfam13360 357809010923 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357809010924 active site 357809010925 DNA repair protein RadA; Provisional; Region: PRK11823 357809010926 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 357809010927 Walker A motif/ATP binding site; other site 357809010928 ATP binding site [chemical binding]; other site 357809010929 Walker B motif; other site 357809010930 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 357809010931 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 357809010932 Clp amino terminal domain; Region: Clp_N; pfam02861 357809010933 Clp amino terminal domain; Region: Clp_N; pfam02861 357809010934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809010935 Walker A motif; other site 357809010936 ATP binding site [chemical binding]; other site 357809010937 Walker B motif; other site 357809010938 arginine finger; other site 357809010939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809010940 Walker A motif; other site 357809010941 ATP binding site [chemical binding]; other site 357809010942 Walker B motif; other site 357809010943 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357809010944 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 357809010945 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 357809010946 ADP binding site [chemical binding]; other site 357809010947 phosphagen binding site; other site 357809010948 substrate specificity loop; other site 357809010949 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 357809010950 catalytic residue [active] 357809010951 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 357809010952 Predicted transcriptional regulators [Transcription]; Region: COG1725 357809010953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809010954 DNA-binding site [nucleotide binding]; DNA binding site 357809010955 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 357809010956 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 357809010957 Bacterial SH3 domain; Region: SH3_3; cl17532 357809010958 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809010959 Bacterial SH3 domain; Region: SH3_3; pfam08239 357809010960 Bacterial SH3 domain; Region: SH3_3; cl17532 357809010961 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 357809010962 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 357809010963 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 357809010964 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 357809010965 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 357809010966 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 357809010967 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 357809010968 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 357809010969 active site 357809010970 substrate binding site [chemical binding]; other site 357809010971 cosubstrate binding site; other site 357809010972 catalytic site [active] 357809010973 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 357809010974 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 357809010975 dimerization interface [polypeptide binding]; other site 357809010976 putative ATP binding site [chemical binding]; other site 357809010977 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 357809010978 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357809010979 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357809010980 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357809010981 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 357809010982 active site residue [active] 357809010983 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 357809010984 CPxP motif; other site 357809010985 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 357809010986 AIR carboxylase; Region: AIRC; pfam00731 357809010987 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 357809010988 VanZ like family; Region: VanZ; pfam04892 357809010989 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 357809010990 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 357809010991 putative tRNA-binding site [nucleotide binding]; other site 357809010992 B3/4 domain; Region: B3_4; pfam03483 357809010993 tRNA synthetase B5 domain; Region: B5; pfam03484 357809010994 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 357809010995 dimer interface [polypeptide binding]; other site 357809010996 motif 1; other site 357809010997 motif 3; other site 357809010998 motif 2; other site 357809010999 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 357809011000 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 357809011001 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 357809011002 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 357809011003 dimer interface [polypeptide binding]; other site 357809011004 motif 1; other site 357809011005 active site 357809011006 motif 2; other site 357809011007 motif 3; other site 357809011008 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 357809011009 Stage II sporulation protein; Region: SpoIID; pfam08486 357809011010 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 357809011011 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 357809011012 active site 357809011013 HIGH motif; other site 357809011014 dimer interface [polypeptide binding]; other site 357809011015 KMSKS motif; other site 357809011016 dihydrodipicolinate reductase; Provisional; Region: PRK00048 357809011017 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 357809011018 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 357809011019 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 357809011020 dihydrodipicolinate synthase; Region: dapA; TIGR00674 357809011021 dimer interface [polypeptide binding]; other site 357809011022 active site 357809011023 catalytic residue [active] 357809011024 single-stranded DNA-binding protein; Provisional; Region: PRK05813 357809011025 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357809011026 dimer interface [polypeptide binding]; other site 357809011027 ssDNA binding site [nucleotide binding]; other site 357809011028 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357809011029 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 357809011030 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 357809011031 G1 box; other site 357809011032 putative GEF interaction site [polypeptide binding]; other site 357809011033 GTP/Mg2+ binding site [chemical binding]; other site 357809011034 Switch I region; other site 357809011035 G2 box; other site 357809011036 G3 box; other site 357809011037 Switch II region; other site 357809011038 G4 box; other site 357809011039 G5 box; other site 357809011040 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 357809011041 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 357809011042 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 357809011043 peptidase T-like protein; Region: PepT-like; TIGR01883 357809011044 metal binding site [ion binding]; metal-binding site 357809011045 putative dimer interface [polypeptide binding]; other site 357809011046 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 357809011047 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 357809011048 putative ATP binding site [chemical binding]; other site 357809011049 putative substrate interface [chemical binding]; other site 357809011050 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 357809011051 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 357809011052 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 357809011053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357809011054 ABC-ATPase subunit interface; other site 357809011055 dimer interface [polypeptide binding]; other site 357809011056 putative PBP binding regions; other site 357809011057 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 357809011058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809011059 Walker A/P-loop; other site 357809011060 ATP binding site [chemical binding]; other site 357809011061 Q-loop/lid; other site 357809011062 ABC transporter signature motif; other site 357809011063 Walker B; other site 357809011064 D-loop; other site 357809011065 H-loop/switch region; other site 357809011066 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357809011067 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 357809011068 intersubunit interface [polypeptide binding]; other site 357809011069 Domain of unknown function (DUF368); Region: DUF368; pfam04018 357809011070 Acyltransferase family; Region: Acyl_transf_3; pfam01757 357809011071 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 357809011072 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 357809011073 NAD(P) binding site [chemical binding]; other site 357809011074 homodimer interface [polypeptide binding]; other site 357809011075 substrate binding site [chemical binding]; other site 357809011076 active site 357809011077 O-Antigen ligase; Region: Wzy_C; pfam04932 357809011078 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809011079 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357809011080 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 357809011081 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 357809011082 active site 357809011083 homodimer interface [polypeptide binding]; other site 357809011084 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 357809011085 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 357809011086 putative NAD(P) binding site [chemical binding]; other site 357809011087 active site 357809011088 putative substrate binding site [chemical binding]; other site 357809011089 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 357809011090 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 357809011091 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 357809011092 NAD(P) binding site [chemical binding]; other site 357809011093 homodimer interface [polypeptide binding]; other site 357809011094 substrate binding site [chemical binding]; other site 357809011095 active site 357809011096 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 357809011097 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 357809011098 putative glycosyl transferase; Provisional; Region: PRK10307 357809011099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357809011100 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 357809011101 NAD(P) binding site [chemical binding]; other site 357809011102 active site 357809011103 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357809011104 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 357809011105 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 357809011106 Int/Topo IB signature motif; other site 357809011107 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 357809011108 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 357809011109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809011110 catalytic residue [active] 357809011111 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 357809011112 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809011113 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809011114 Walker A/P-loop; other site 357809011115 ATP binding site [chemical binding]; other site 357809011116 Q-loop/lid; other site 357809011117 ABC transporter signature motif; other site 357809011118 Walker B; other site 357809011119 D-loop; other site 357809011120 H-loop/switch region; other site 357809011121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809011122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809011123 dimerization interface [polypeptide binding]; other site 357809011124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809011125 dimer interface [polypeptide binding]; other site 357809011126 phosphorylation site [posttranslational modification] 357809011127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809011128 ATP binding site [chemical binding]; other site 357809011129 Mg2+ binding site [ion binding]; other site 357809011130 G-X-G motif; other site 357809011131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809011132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809011133 active site 357809011134 phosphorylation site [posttranslational modification] 357809011135 intermolecular recognition site; other site 357809011136 dimerization interface [polypeptide binding]; other site 357809011137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809011138 DNA binding site [nucleotide binding] 357809011139 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 357809011140 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 357809011141 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 357809011142 active site 357809011143 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 357809011144 Family of unknown function (DUF633); Region: DUF633; pfam04816 357809011145 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 357809011146 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 357809011147 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357809011148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809011149 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357809011150 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809011151 DNA binding residues [nucleotide binding] 357809011152 DNA primase; Validated; Region: dnaG; PRK05667 357809011153 CHC2 zinc finger; Region: zf-CHC2; pfam01807 357809011154 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 357809011155 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 357809011156 active site 357809011157 metal binding site [ion binding]; metal-binding site 357809011158 interdomain interaction site; other site 357809011159 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 357809011160 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 357809011161 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809011162 Zn2+ binding site [ion binding]; other site 357809011163 Mg2+ binding site [ion binding]; other site 357809011164 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 357809011165 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 357809011166 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 357809011167 G1 box; other site 357809011168 GTP/Mg2+ binding site [chemical binding]; other site 357809011169 Switch I region; other site 357809011170 G2 box; other site 357809011171 G3 box; other site 357809011172 Switch II region; other site 357809011173 G4 box; other site 357809011174 G5 box; other site 357809011175 Nucleoside recognition; Region: Gate; pfam07670 357809011176 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 357809011177 Nucleoside recognition; Region: Gate; pfam07670 357809011178 FeoA domain; Region: FeoA; pfam04023 357809011179 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 357809011180 Response regulator receiver domain; Region: Response_reg; pfam00072 357809011181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809011182 active site 357809011183 phosphorylation site [posttranslational modification] 357809011184 intermolecular recognition site; other site 357809011185 dimerization interface [polypeptide binding]; other site 357809011186 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 357809011187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809011188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809011189 homodimer interface [polypeptide binding]; other site 357809011190 catalytic residue [active] 357809011191 aspartate aminotransferase; Provisional; Region: PRK06836 357809011192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357809011193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809011194 homodimer interface [polypeptide binding]; other site 357809011195 catalytic residue [active] 357809011196 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 357809011197 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357809011198 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357809011199 Walker A/P-loop; other site 357809011200 ATP binding site [chemical binding]; other site 357809011201 Q-loop/lid; other site 357809011202 ABC transporter signature motif; other site 357809011203 Walker B; other site 357809011204 D-loop; other site 357809011205 H-loop/switch region; other site 357809011206 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357809011207 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357809011208 Walker A/P-loop; other site 357809011209 ATP binding site [chemical binding]; other site 357809011210 Q-loop/lid; other site 357809011211 ABC transporter signature motif; other site 357809011212 Walker B; other site 357809011213 D-loop; other site 357809011214 H-loop/switch region; other site 357809011215 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357809011216 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357809011217 TM-ABC transporter signature motif; other site 357809011218 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357809011219 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357809011220 TM-ABC transporter signature motif; other site 357809011221 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357809011222 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 357809011223 putative ligand binding site [chemical binding]; other site 357809011224 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 357809011225 active site 357809011226 catalytic triad [active] 357809011227 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 357809011228 putative active site [active] 357809011229 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 357809011230 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 357809011231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809011232 Walker A motif; other site 357809011233 ATP binding site [chemical binding]; other site 357809011234 Walker B motif; other site 357809011235 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357809011236 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 357809011237 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 357809011238 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357809011239 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 357809011240 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357809011241 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357809011242 protein binding site [polypeptide binding]; other site 357809011243 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 357809011244 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 357809011245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357809011246 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357809011247 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 357809011248 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 357809011249 Walker A/P-loop; other site 357809011250 ATP binding site [chemical binding]; other site 357809011251 Q-loop/lid; other site 357809011252 ABC transporter signature motif; other site 357809011253 Walker B; other site 357809011254 D-loop; other site 357809011255 H-loop/switch region; other site 357809011256 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 357809011257 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357809011258 2-isopropylmalate synthase; Validated; Region: PRK03739 357809011259 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 357809011260 active site 357809011261 catalytic residues [active] 357809011262 metal binding site [ion binding]; metal-binding site 357809011263 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 357809011264 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357809011265 dimerization domain swap beta strand [polypeptide binding]; other site 357809011266 regulatory protein interface [polypeptide binding]; other site 357809011267 active site 357809011268 regulatory phosphorylation site [posttranslational modification]; other site 357809011269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 357809011270 Uncharacterized conserved protein [Function unknown]; Region: COG1624 357809011271 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 357809011272 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 357809011273 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 357809011274 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357809011275 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 357809011276 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 357809011277 dimer interface [polypeptide binding]; other site 357809011278 putative anticodon binding site; other site 357809011279 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 357809011280 motif 1; other site 357809011281 active site 357809011282 motif 2; other site 357809011283 motif 3; other site 357809011284 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 357809011285 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 357809011286 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 357809011287 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 357809011288 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357809011289 dimer interface [polypeptide binding]; other site 357809011290 PYR/PP interface [polypeptide binding]; other site 357809011291 TPP binding site [chemical binding]; other site 357809011292 substrate binding site [chemical binding]; other site 357809011293 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 357809011294 Domain of unknown function; Region: EKR; pfam10371 357809011295 4Fe-4S binding domain; Region: Fer4_6; pfam12837 357809011296 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809011297 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 357809011298 TPP-binding site [chemical binding]; other site 357809011299 dimer interface [polypeptide binding]; other site 357809011300 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357809011301 Predicted transcriptional regulators [Transcription]; Region: COG1695 357809011302 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 357809011303 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 357809011304 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357809011305 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357809011306 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357809011307 putative active site [active] 357809011308 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 357809011309 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 357809011310 putative active site cavity [active] 357809011311 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 357809011312 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 357809011313 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 357809011314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809011315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809011316 dimer interface [polypeptide binding]; other site 357809011317 conserved gate region; other site 357809011318 putative PBP binding loops; other site 357809011319 ABC-ATPase subunit interface; other site 357809011320 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809011321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809011322 dimer interface [polypeptide binding]; other site 357809011323 conserved gate region; other site 357809011324 putative PBP binding loops; other site 357809011325 ABC-ATPase subunit interface; other site 357809011326 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809011327 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 357809011328 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 357809011329 putative active site [active] 357809011330 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 357809011331 active site 357809011332 catalytic triad [active] 357809011333 oxyanion hole [active] 357809011334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357809011335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357809011336 nucleotide binding site [chemical binding]; other site 357809011337 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 357809011338 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 357809011339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809011340 FeS/SAM binding site; other site 357809011341 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 357809011342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809011343 Walker A/P-loop; other site 357809011344 ATP binding site [chemical binding]; other site 357809011345 Q-loop/lid; other site 357809011346 ABC transporter signature motif; other site 357809011347 Walker B; other site 357809011348 D-loop; other site 357809011349 H-loop/switch region; other site 357809011350 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 357809011351 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 357809011352 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 357809011353 ATP binding site [chemical binding]; other site 357809011354 substrate interface [chemical binding]; other site 357809011355 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 357809011356 Peptidase family M50; Region: Peptidase_M50; pfam02163 357809011357 active site 357809011358 putative substrate binding region [chemical binding]; other site 357809011359 uncharacterized domain; Region: TIGR00702 357809011360 YcaO-like family; Region: YcaO; pfam02624 357809011361 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 357809011362 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 357809011363 active site 357809011364 dimer interface [polypeptide binding]; other site 357809011365 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 357809011366 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 357809011367 active site 357809011368 trimer interface [polypeptide binding]; other site 357809011369 allosteric site; other site 357809011370 active site lid [active] 357809011371 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 357809011372 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 357809011373 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 357809011374 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357809011375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809011376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809011377 DNA binding site [nucleotide binding] 357809011378 domain linker motif; other site 357809011379 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809011380 dimerization interface [polypeptide binding]; other site 357809011381 ligand binding site [chemical binding]; other site 357809011382 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 357809011383 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 357809011384 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 357809011385 putative sugar binding sites [chemical binding]; other site 357809011386 Q-X-W motif; other site 357809011387 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809011388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809011389 dimer interface [polypeptide binding]; other site 357809011390 conserved gate region; other site 357809011391 putative PBP binding loops; other site 357809011392 ABC-ATPase subunit interface; other site 357809011393 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357809011394 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 357809011395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357809011396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809011397 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357809011398 HAMP domain; Region: HAMP; pfam00672 357809011399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809011400 dimer interface [polypeptide binding]; other site 357809011401 putative CheW interface [polypeptide binding]; other site 357809011402 RNA polymerase sigma factor; Provisional; Region: PRK11924 357809011403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357809011404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357809011405 DNA binding residues [nucleotide binding] 357809011406 DHHW protein; Region: DHHW; pfam14286 357809011407 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 357809011408 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 357809011409 G1 box; other site 357809011410 putative GEF interaction site [polypeptide binding]; other site 357809011411 GTP/Mg2+ binding site [chemical binding]; other site 357809011412 Switch I region; other site 357809011413 G2 box; other site 357809011414 G3 box; other site 357809011415 Switch II region; other site 357809011416 G4 box; other site 357809011417 G5 box; other site 357809011418 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 357809011419 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 357809011420 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809011421 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809011422 Walker A/P-loop; other site 357809011423 ATP binding site [chemical binding]; other site 357809011424 Q-loop/lid; other site 357809011425 ABC transporter signature motif; other site 357809011426 Walker B; other site 357809011427 D-loop; other site 357809011428 H-loop/switch region; other site 357809011429 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 357809011430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809011431 ABC transporter signature motif; other site 357809011432 Walker B; other site 357809011433 D-loop; other site 357809011434 H-loop/switch region; other site 357809011435 LytTr DNA-binding domain; Region: LytTR; pfam04397 357809011436 aspartate kinase; Reviewed; Region: PRK06635 357809011437 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 357809011438 putative nucleotide binding site [chemical binding]; other site 357809011439 putative catalytic residues [active] 357809011440 putative Mg ion binding site [ion binding]; other site 357809011441 putative aspartate binding site [chemical binding]; other site 357809011442 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 357809011443 putative allosteric regulatory site; other site 357809011444 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 357809011445 homoserine dehydrogenase; Provisional; Region: PRK06349 357809011446 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 357809011447 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 357809011448 hypothetical protein; Provisional; Region: PRK04435 357809011449 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 357809011450 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357809011451 C-terminal peptidase (prc); Region: prc; TIGR00225 357809011452 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 357809011453 protein binding site [polypeptide binding]; other site 357809011454 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 357809011455 Catalytic dyad [active] 357809011456 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357809011457 Peptidase family M23; Region: Peptidase_M23; pfam01551 357809011458 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 357809011459 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 357809011460 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 357809011461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809011462 Walker A/P-loop; other site 357809011463 ATP binding site [chemical binding]; other site 357809011464 Q-loop/lid; other site 357809011465 ABC transporter signature motif; other site 357809011466 Walker B; other site 357809011467 D-loop; other site 357809011468 H-loop/switch region; other site 357809011469 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 357809011470 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357809011471 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 357809011472 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 357809011473 Walker A/P-loop; other site 357809011474 ATP binding site [chemical binding]; other site 357809011475 Q-loop/lid; other site 357809011476 ABC transporter signature motif; other site 357809011477 Walker B; other site 357809011478 D-loop; other site 357809011479 H-loop/switch region; other site 357809011480 TOBE domain; Region: TOBE; pfam03459 357809011481 Uncharacterized conserved protein [Function unknown]; Region: COG1284 357809011482 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 357809011483 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 357809011484 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 357809011485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357809011486 NAD(P) binding site [chemical binding]; other site 357809011487 active site 357809011488 hypothetical protein; Provisional; Region: PRK08262 357809011489 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 357809011490 metal binding site [ion binding]; metal-binding site 357809011491 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 357809011492 hypothetical protein; Provisional; Region: PRK00955 357809011493 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 357809011494 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 357809011495 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 357809011496 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 357809011497 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 357809011498 active site 357809011499 classical (c) SDRs; Region: SDR_c; cd05233 357809011500 NAD(P) binding site [chemical binding]; other site 357809011501 active site 357809011502 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 357809011503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357809011504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357809011505 putative deaminase; Validated; Region: PRK06846 357809011506 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 357809011507 active site 357809011508 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809011509 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 357809011510 DNA binding residues [nucleotide binding] 357809011511 dimer interface [polypeptide binding]; other site 357809011512 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 357809011513 Short C-terminal domain; Region: SHOCT; pfam09851 357809011514 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 357809011515 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357809011516 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 357809011517 AAA domain; Region: AAA_33; pfam13671 357809011518 P-loop motif; other site 357809011519 ATP binding site [chemical binding]; other site 357809011520 Chloramphenicol (Cm) binding site [chemical binding]; other site 357809011521 catalytic residue [active] 357809011522 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 357809011523 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 357809011524 23S rRNA interface [nucleotide binding]; other site 357809011525 L3 interface [polypeptide binding]; other site 357809011526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357809011527 Histidine kinase; Region: HisKA_3; pfam07730 357809011528 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357809011529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357809011530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809011531 active site 357809011532 phosphorylation site [posttranslational modification] 357809011533 intermolecular recognition site; other site 357809011534 dimerization interface [polypeptide binding]; other site 357809011535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357809011536 DNA binding residues [nucleotide binding] 357809011537 dimerization interface [polypeptide binding]; other site 357809011538 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809011539 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809011540 Walker A/P-loop; other site 357809011541 ATP binding site [chemical binding]; other site 357809011542 Q-loop/lid; other site 357809011543 ABC transporter signature motif; other site 357809011544 Walker B; other site 357809011545 D-loop; other site 357809011546 H-loop/switch region; other site 357809011547 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809011548 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 357809011549 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 357809011550 dimerization interface 3.5A [polypeptide binding]; other site 357809011551 active site 357809011552 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 357809011553 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 357809011554 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357809011555 Walker A/P-loop; other site 357809011556 ATP binding site [chemical binding]; other site 357809011557 Q-loop/lid; other site 357809011558 ABC transporter signature motif; other site 357809011559 Walker B; other site 357809011560 D-loop; other site 357809011561 H-loop/switch region; other site 357809011562 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 357809011563 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 357809011564 Walker A/P-loop; other site 357809011565 ATP binding site [chemical binding]; other site 357809011566 Q-loop/lid; other site 357809011567 ABC transporter signature motif; other site 357809011568 Walker B; other site 357809011569 D-loop; other site 357809011570 H-loop/switch region; other site 357809011571 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 357809011572 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 357809011573 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 357809011574 alphaNTD - beta interaction site [polypeptide binding]; other site 357809011575 alphaNTD homodimer interface [polypeptide binding]; other site 357809011576 alphaNTD - beta' interaction site [polypeptide binding]; other site 357809011577 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 357809011578 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 357809011579 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 357809011580 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357809011581 RNA binding surface [nucleotide binding]; other site 357809011582 30S ribosomal protein S11; Validated; Region: PRK05309 357809011583 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 357809011584 30S ribosomal protein S13; Region: bact_S13; TIGR03631 357809011585 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 357809011586 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 357809011587 rRNA binding site [nucleotide binding]; other site 357809011588 predicted 30S ribosome binding site; other site 357809011589 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 357809011590 active site 357809011591 adenylate kinase; Reviewed; Region: adk; PRK00279 357809011592 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 357809011593 AMP-binding site [chemical binding]; other site 357809011594 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 357809011595 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 357809011596 SecY translocase; Region: SecY; pfam00344 357809011597 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 357809011598 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 357809011599 23S rRNA binding site [nucleotide binding]; other site 357809011600 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 357809011601 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 357809011602 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 357809011603 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 357809011604 23S rRNA interface [nucleotide binding]; other site 357809011605 L21e interface [polypeptide binding]; other site 357809011606 5S rRNA interface [nucleotide binding]; other site 357809011607 L27 interface [polypeptide binding]; other site 357809011608 L5 interface [polypeptide binding]; other site 357809011609 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 357809011610 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357809011611 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357809011612 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 357809011613 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 357809011614 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 357809011615 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 357809011616 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 357809011617 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 357809011618 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 357809011619 RNA binding site [nucleotide binding]; other site 357809011620 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 357809011621 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 357809011622 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 357809011623 putative translocon interaction site; other site 357809011624 23S rRNA interface [nucleotide binding]; other site 357809011625 signal recognition particle (SRP54) interaction site; other site 357809011626 L23 interface [polypeptide binding]; other site 357809011627 trigger factor interaction site; other site 357809011628 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 357809011629 23S rRNA interface [nucleotide binding]; other site 357809011630 5S rRNA interface [nucleotide binding]; other site 357809011631 putative antibiotic binding site [chemical binding]; other site 357809011632 L25 interface [polypeptide binding]; other site 357809011633 L27 interface [polypeptide binding]; other site 357809011634 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 357809011635 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 357809011636 G-X-X-G motif; other site 357809011637 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 357809011638 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 357809011639 protein-rRNA interface [nucleotide binding]; other site 357809011640 putative translocon binding site; other site 357809011641 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 357809011642 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 357809011643 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 357809011644 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 357809011645 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 357809011646 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 357809011647 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 357809011648 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 357809011649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809011650 dimerization interface [polypeptide binding]; other site 357809011651 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809011652 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809011653 dimer interface [polypeptide binding]; other site 357809011654 putative CheW interface [polypeptide binding]; other site 357809011655 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 357809011656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357809011657 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 357809011658 Repair protein; Region: Repair_PSII; cl01535 357809011659 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 357809011660 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 357809011661 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357809011662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357809011663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357809011664 metal binding site [ion binding]; metal-binding site 357809011665 active site 357809011666 I-site; other site 357809011667 BioY family; Region: BioY; pfam02632 357809011668 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 357809011669 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 357809011670 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 357809011671 NADP binding site [chemical binding]; other site 357809011672 active site 357809011673 putative substrate binding site [chemical binding]; other site 357809011674 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 357809011675 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 357809011676 NAD binding site [chemical binding]; other site 357809011677 substrate binding site [chemical binding]; other site 357809011678 homodimer interface [polypeptide binding]; other site 357809011679 active site 357809011680 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 357809011681 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 357809011682 substrate binding site; other site 357809011683 tetramer interface; other site 357809011684 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 357809011685 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 357809011686 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 357809011687 intersubunit interface [polypeptide binding]; other site 357809011688 active site 357809011689 zinc binding site [ion binding]; other site 357809011690 Na+ binding site [ion binding]; other site 357809011691 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 357809011692 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 357809011693 active site 357809011694 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 357809011695 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 357809011696 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 357809011697 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 357809011698 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 357809011699 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 357809011700 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 357809011701 G-loop; other site 357809011702 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 357809011703 DNA binding site [nucleotide binding] 357809011704 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 357809011705 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 357809011706 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 357809011707 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 357809011708 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 357809011709 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 357809011710 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 357809011711 RPB1 interaction site [polypeptide binding]; other site 357809011712 RPB10 interaction site [polypeptide binding]; other site 357809011713 RPB11 interaction site [polypeptide binding]; other site 357809011714 RPB3 interaction site [polypeptide binding]; other site 357809011715 RPB12 interaction site [polypeptide binding]; other site 357809011716 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 357809011717 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357809011718 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809011719 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357809011720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809011721 motif II; other site 357809011722 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357809011723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357809011724 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357809011725 putative substrate translocation pore; other site 357809011726 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 357809011727 core dimer interface [polypeptide binding]; other site 357809011728 peripheral dimer interface [polypeptide binding]; other site 357809011729 L10 interface [polypeptide binding]; other site 357809011730 L11 interface [polypeptide binding]; other site 357809011731 putative EF-Tu interaction site [polypeptide binding]; other site 357809011732 putative EF-G interaction site [polypeptide binding]; other site 357809011733 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 357809011734 23S rRNA interface [nucleotide binding]; other site 357809011735 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 357809011736 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 357809011737 mRNA/rRNA interface [nucleotide binding]; other site 357809011738 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 357809011739 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 357809011740 23S rRNA interface [nucleotide binding]; other site 357809011741 L7/L12 interface [polypeptide binding]; other site 357809011742 putative thiostrepton binding site; other site 357809011743 L25 interface [polypeptide binding]; other site 357809011744 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 357809011745 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 357809011746 putative homodimer interface [polypeptide binding]; other site 357809011747 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 357809011748 heterodimer interface [polypeptide binding]; other site 357809011749 homodimer interface [polypeptide binding]; other site 357809011750 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 357809011751 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 357809011752 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 357809011753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809011754 active site 357809011755 phosphorylation site [posttranslational modification] 357809011756 intermolecular recognition site; other site 357809011757 dimerization interface [polypeptide binding]; other site 357809011758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809011759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809011760 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 357809011761 catalytic triad [active] 357809011762 putative active site [active] 357809011763 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 357809011764 oligoendopeptidase F; Region: pepF; TIGR00181 357809011765 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 357809011766 active site 357809011767 Zn binding site [ion binding]; other site 357809011768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357809011769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357809011770 DNA binding site [nucleotide binding] 357809011771 domain linker motif; other site 357809011772 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357809011773 dimerization interface [polypeptide binding]; other site 357809011774 ligand binding site [chemical binding]; other site 357809011775 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 357809011776 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357809011777 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 357809011778 FtsX-like permease family; Region: FtsX; pfam02687 357809011779 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 357809011780 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 357809011781 CARDB; Region: CARDB; pfam07705 357809011782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357809011783 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357809011784 Walker A/P-loop; other site 357809011785 ATP binding site [chemical binding]; other site 357809011786 Q-loop/lid; other site 357809011787 ABC transporter signature motif; other site 357809011788 Walker B; other site 357809011789 D-loop; other site 357809011790 H-loop/switch region; other site 357809011791 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 357809011792 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357809011793 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357809011794 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357809011795 Protein of unknown function DUF58; Region: DUF58; pfam01882 357809011796 MoxR-like ATPases [General function prediction only]; Region: COG0714 357809011797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809011798 Walker A motif; other site 357809011799 ATP binding site [chemical binding]; other site 357809011800 Walker B motif; other site 357809011801 arginine finger; other site 357809011802 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 357809011803 dimer interface [polypeptide binding]; other site 357809011804 pyridoxal binding site [chemical binding]; other site 357809011805 ATP binding site [chemical binding]; other site 357809011806 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 357809011807 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357809011808 DNA binding residues [nucleotide binding] 357809011809 dimer interface [polypeptide binding]; other site 357809011810 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 357809011811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357809011812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357809011813 DNA binding residues [nucleotide binding] 357809011814 dimerization interface [polypeptide binding]; other site 357809011815 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 357809011816 putative active site [active] 357809011817 dimerization interface [polypeptide binding]; other site 357809011818 putative tRNAtyr binding site [nucleotide binding]; other site 357809011819 phosphopentomutase; Provisional; Region: PRK05362 357809011820 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 357809011821 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 357809011822 active site 357809011823 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357809011824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357809011825 active site 357809011826 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357809011827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809011828 S-adenosylmethionine binding site [chemical binding]; other site 357809011829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809011830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809011831 ATP binding site [chemical binding]; other site 357809011832 Mg2+ binding site [ion binding]; other site 357809011833 G-X-G motif; other site 357809011834 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 357809011835 HIT family signature motif; other site 357809011836 catalytic residue [active] 357809011837 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 357809011838 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 357809011839 active site 357809011840 homodimer interface [polypeptide binding]; other site 357809011841 TSCPD domain; Region: TSCPD; cl14834 357809011842 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 357809011843 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 357809011844 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 357809011845 HTH domain; Region: HTH_11; pfam08279 357809011846 3H domain; Region: 3H; pfam02829 357809011847 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 357809011848 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 357809011849 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 357809011850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357809011851 active site 357809011852 metal binding site [ion binding]; metal-binding site 357809011853 homotetramer interface [polypeptide binding]; other site 357809011854 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 357809011855 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 357809011856 active site 357809011857 catalytic site [active] 357809011858 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 357809011859 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 357809011860 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 357809011861 gamma subunit interface [polypeptide binding]; other site 357809011862 epsilon subunit interface [polypeptide binding]; other site 357809011863 LBP interface [polypeptide binding]; other site 357809011864 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 357809011865 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357809011866 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 357809011867 alpha subunit interaction interface [polypeptide binding]; other site 357809011868 Walker A motif; other site 357809011869 ATP binding site [chemical binding]; other site 357809011870 Walker B motif; other site 357809011871 inhibitor binding site; inhibition site 357809011872 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357809011873 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 357809011874 core domain interface [polypeptide binding]; other site 357809011875 delta subunit interface [polypeptide binding]; other site 357809011876 epsilon subunit interface [polypeptide binding]; other site 357809011877 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 357809011878 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357809011879 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 357809011880 beta subunit interaction interface [polypeptide binding]; other site 357809011881 Walker A motif; other site 357809011882 ATP binding site [chemical binding]; other site 357809011883 Walker B motif; other site 357809011884 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357809011885 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 357809011886 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 357809011887 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 357809011888 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 357809011889 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 357809011890 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 357809011891 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 357809011892 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 357809011893 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 357809011894 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357809011895 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 357809011896 active site 357809011897 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 357809011898 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 357809011899 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 357809011900 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 357809011901 active site 357809011902 metal binding site [ion binding]; metal-binding site 357809011903 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 357809011904 Glyco_18 domain; Region: Glyco_18; smart00636 357809011905 active site 357809011906 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357809011907 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357809011908 active site 357809011909 ATP binding site [chemical binding]; other site 357809011910 substrate binding site [chemical binding]; other site 357809011911 activation loop (A-loop); other site 357809011912 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 357809011913 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 357809011914 4Fe-4S binding domain; Region: Fer4; cl02805 357809011915 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 357809011916 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357809011917 DNA binding residues [nucleotide binding] 357809011918 replicative DNA helicase; Region: DnaB; TIGR00665 357809011919 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 357809011920 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 357809011921 Walker A motif; other site 357809011922 ATP binding site [chemical binding]; other site 357809011923 Walker B motif; other site 357809011924 DNA binding loops [nucleotide binding] 357809011925 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 357809011926 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 357809011927 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 357809011928 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 357809011929 DHH family; Region: DHH; pfam01368 357809011930 DHHA1 domain; Region: DHHA1; pfam02272 357809011931 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 357809011932 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 357809011933 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 357809011934 Transcriptional regulators [Transcription]; Region: GntR; COG1802 357809011935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809011936 DNA-binding site [nucleotide binding]; DNA binding site 357809011937 FCD domain; Region: FCD; pfam07729 357809011938 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 357809011939 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 357809011940 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 357809011941 Citrate transporter; Region: CitMHS; pfam03600 357809011942 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 357809011943 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 357809011944 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357809011945 Double zinc ribbon; Region: DZR; pfam12773 357809011946 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 357809011947 Double zinc ribbon; Region: DZR; pfam12773 357809011948 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 357809011949 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 357809011950 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 357809011951 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357809011952 dimer interface [polypeptide binding]; other site 357809011953 ssDNA binding site [nucleotide binding]; other site 357809011954 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357809011955 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 357809011956 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 357809011957 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 357809011958 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 357809011959 Peptidase family M23; Region: Peptidase_M23; pfam01551 357809011960 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 357809011961 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 357809011962 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 357809011963 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 357809011964 Walker A/P-loop; other site 357809011965 ATP binding site [chemical binding]; other site 357809011966 Q-loop/lid; other site 357809011967 ABC transporter signature motif; other site 357809011968 Walker B; other site 357809011969 D-loop; other site 357809011970 H-loop/switch region; other site 357809011971 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809011972 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809011973 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 357809011974 Walker A/P-loop; other site 357809011975 ATP binding site [chemical binding]; other site 357809011976 Q-loop/lid; other site 357809011977 ABC transporter signature motif; other site 357809011978 Walker B; other site 357809011979 D-loop; other site 357809011980 H-loop/switch region; other site 357809011981 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357809011982 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357809011983 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 357809011984 Walker A/P-loop; other site 357809011985 ATP binding site [chemical binding]; other site 357809011986 Q-loop/lid; other site 357809011987 ABC transporter signature motif; other site 357809011988 Walker B; other site 357809011989 D-loop; other site 357809011990 H-loop/switch region; other site 357809011991 Transcriptional regulator [Transcription]; Region: LytR; COG1316 357809011992 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 357809011993 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 357809011994 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 357809011995 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 357809011996 trimer interface [polypeptide binding]; other site 357809011997 active site 357809011998 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 357809011999 catalytic site [active] 357809012000 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 357809012001 Rubredoxin; Region: Rubredoxin; pfam00301 357809012002 iron binding site [ion binding]; other site 357809012003 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357809012004 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357809012005 putative acyl-acceptor binding pocket; other site 357809012006 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 357809012007 glutamate racemase; Provisional; Region: PRK00865 357809012008 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 357809012009 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 357809012010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357809012011 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 357809012012 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 357809012013 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 357809012014 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 357809012015 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 357809012016 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 357809012017 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 357809012018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357809012019 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 357809012020 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 357809012021 active site 357809012022 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 357809012023 DRTGG domain; Region: DRTGG; pfam07085 357809012024 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 357809012025 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 357809012026 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 357809012027 Putative Fe-S cluster; Region: FeS; cl17515 357809012028 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 357809012029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809012030 ATP binding site [chemical binding]; other site 357809012031 Mg2+ binding site [ion binding]; other site 357809012032 G-X-G motif; other site 357809012033 DRTGG domain; Region: DRTGG; pfam07085 357809012034 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 357809012035 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 357809012036 putative dimer interface [polypeptide binding]; other site 357809012037 [2Fe-2S] cluster binding site [ion binding]; other site 357809012038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809012039 ATP binding site [chemical binding]; other site 357809012040 Mg2+ binding site [ion binding]; other site 357809012041 G-X-G motif; other site 357809012042 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 357809012043 dimer interface [polypeptide binding]; other site 357809012044 [2Fe-2S] cluster binding site [ion binding]; other site 357809012045 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 357809012046 dimer interface [polypeptide binding]; other site 357809012047 [2Fe-2S] cluster binding site [ion binding]; other site 357809012048 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 357809012049 SLBB domain; Region: SLBB; pfam10531 357809012050 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 357809012051 4Fe-4S binding domain; Region: Fer4; pfam00037 357809012052 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 357809012053 4Fe-4S binding domain; Region: Fer4; pfam00037 357809012054 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 357809012055 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357809012056 catalytic loop [active] 357809012057 iron binding site [ion binding]; other site 357809012058 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 357809012059 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357809012060 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 357809012061 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 357809012062 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 357809012063 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 357809012064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357809012065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809012066 Coenzyme A binding pocket [chemical binding]; other site 357809012067 MoxR-like ATPases [General function prediction only]; Region: COG0714 357809012068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809012069 Walker A motif; other site 357809012070 ATP binding site [chemical binding]; other site 357809012071 Walker B motif; other site 357809012072 arginine finger; other site 357809012073 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 357809012074 Protein of unknown function DUF58; Region: DUF58; pfam01882 357809012075 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 357809012076 PrcB C-terminal; Region: PrcB_C; pfam14343 357809012077 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 357809012078 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 357809012079 metal binding site 2 [ion binding]; metal-binding site 357809012080 putative DNA binding helix; other site 357809012081 metal binding site 1 [ion binding]; metal-binding site 357809012082 dimer interface [polypeptide binding]; other site 357809012083 structural Zn2+ binding site [ion binding]; other site 357809012084 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 357809012085 Rubredoxin; Region: Rubredoxin; pfam00301 357809012086 iron binding site [ion binding]; other site 357809012087 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 357809012088 Rubrerythrin [Energy production and conversion]; Region: COG1592 357809012089 diiron binding motif [ion binding]; other site 357809012090 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 357809012091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809012092 motif II; other site 357809012093 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 357809012094 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357809012095 ATP binding site [chemical binding]; other site 357809012096 Mg++ binding site [ion binding]; other site 357809012097 motif III; other site 357809012098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357809012099 nucleotide binding region [chemical binding]; other site 357809012100 ATP-binding site [chemical binding]; other site 357809012101 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 357809012102 RNA binding site [nucleotide binding]; other site 357809012103 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 357809012104 Clp amino terminal domain; Region: Clp_N; pfam02861 357809012105 Clp amino terminal domain; Region: Clp_N; pfam02861 357809012106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809012107 Walker A motif; other site 357809012108 ATP binding site [chemical binding]; other site 357809012109 Walker B motif; other site 357809012110 arginine finger; other site 357809012111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809012112 Walker A motif; other site 357809012113 ATP binding site [chemical binding]; other site 357809012114 Walker B motif; other site 357809012115 arginine finger; other site 357809012116 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357809012117 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357809012118 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357809012119 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 357809012120 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 357809012121 HflK protein; Region: hflK; TIGR01933 357809012122 PEGA domain; Region: PEGA; pfam08308 357809012123 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 357809012124 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 357809012125 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 357809012126 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 357809012127 active site 357809012128 NTP binding site [chemical binding]; other site 357809012129 metal binding triad [ion binding]; metal-binding site 357809012130 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 357809012131 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809012132 Zn2+ binding site [ion binding]; other site 357809012133 Mg2+ binding site [ion binding]; other site 357809012134 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 357809012135 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 357809012136 active site 357809012137 catalytic triad [active] 357809012138 oxyanion hole [active] 357809012139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357809012140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809012141 DNA-binding site [nucleotide binding]; DNA binding site 357809012142 FCD domain; Region: FCD; pfam07729 357809012143 Dehydratase family; Region: ILVD_EDD; pfam00920 357809012144 fructuronate transporter; Provisional; Region: PRK10034; cl15264 357809012145 GntP family permease; Region: GntP_permease; pfam02447 357809012146 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 357809012147 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357809012148 active site 357809012149 HIGH motif; other site 357809012150 nucleotide binding site [chemical binding]; other site 357809012151 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 357809012152 active site 357809012153 KMSKS motif; other site 357809012154 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 357809012155 tRNA binding surface [nucleotide binding]; other site 357809012156 anticodon binding site; other site 357809012157 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 357809012158 dimer interface [polypeptide binding]; other site 357809012159 Citrate synthase; Region: Citrate_synt; pfam00285 357809012160 active site 357809012161 citrylCoA binding site [chemical binding]; other site 357809012162 oxalacetate/citrate binding site [chemical binding]; other site 357809012163 coenzyme A binding site [chemical binding]; other site 357809012164 catalytic triad [active] 357809012165 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357809012166 MarR family; Region: MarR_2; pfam12802 357809012167 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 357809012168 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 357809012169 active site 357809012170 prolyl-tRNA synthetase; Provisional; Region: PRK08661 357809012171 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 357809012172 dimer interface [polypeptide binding]; other site 357809012173 motif 1; other site 357809012174 active site 357809012175 motif 2; other site 357809012176 motif 3; other site 357809012177 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 357809012178 anticodon binding site; other site 357809012179 zinc-binding site [ion binding]; other site 357809012180 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 357809012181 Domain of unknown function DUF20; Region: UPF0118; pfam01594 357809012182 cytidylate kinase; Provisional; Region: PRK04182 357809012183 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 357809012184 active site 357809012185 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 357809012186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809012187 Walker A/P-loop; other site 357809012188 ATP binding site [chemical binding]; other site 357809012189 Q-loop/lid; other site 357809012190 ABC transporter signature motif; other site 357809012191 Walker B; other site 357809012192 D-loop; other site 357809012193 H-loop/switch region; other site 357809012194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809012195 dimer interface [polypeptide binding]; other site 357809012196 conserved gate region; other site 357809012197 putative PBP binding loops; other site 357809012198 ABC-ATPase subunit interface; other site 357809012199 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 357809012200 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 357809012201 substrate binding site [chemical binding]; other site 357809012202 active site 357809012203 catalytic residues [active] 357809012204 heterodimer interface [polypeptide binding]; other site 357809012205 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 357809012206 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 357809012207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357809012208 catalytic residue [active] 357809012209 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 357809012210 active site 357809012211 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 357809012212 active site 357809012213 ribulose/triose binding site [chemical binding]; other site 357809012214 phosphate binding site [ion binding]; other site 357809012215 substrate (anthranilate) binding pocket [chemical binding]; other site 357809012216 product (indole) binding pocket [chemical binding]; other site 357809012217 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 357809012218 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 357809012219 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 357809012220 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 357809012221 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 357809012222 glutamine binding [chemical binding]; other site 357809012223 catalytic triad [active] 357809012224 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 357809012225 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 357809012226 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 357809012227 Flagellar protein FliS; Region: FliS; cl00654 357809012228 flagellin; Provisional; Region: PRK12806 357809012229 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 357809012230 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 357809012231 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 357809012232 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 357809012233 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 357809012234 active site 357809012235 metal-binding site [ion binding] 357809012236 nucleotide-binding site [chemical binding]; other site 357809012237 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 357809012238 catalytic domain interface [polypeptide binding]; other site 357809012239 putative homodimer interface [polypeptide binding]; other site 357809012240 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 357809012241 Protein of unknown function, DUF608; Region: DUF608; pfam04685 357809012242 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 357809012243 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 357809012244 active site 357809012245 substrate binding site [chemical binding]; other site 357809012246 metal binding site [ion binding]; metal-binding site 357809012247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357809012248 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357809012249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809012250 dimerization interface [polypeptide binding]; other site 357809012251 Histidine kinase; Region: His_kinase; pfam06580 357809012252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809012253 ATP binding site [chemical binding]; other site 357809012254 Mg2+ binding site [ion binding]; other site 357809012255 G-X-G motif; other site 357809012256 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357809012257 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357809012258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809012259 dimer interface [polypeptide binding]; other site 357809012260 conserved gate region; other site 357809012261 putative PBP binding loops; other site 357809012262 ABC-ATPase subunit interface; other site 357809012263 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357809012264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357809012265 dimer interface [polypeptide binding]; other site 357809012266 conserved gate region; other site 357809012267 putative PBP binding loops; other site 357809012268 ABC-ATPase subunit interface; other site 357809012269 Response regulator receiver domain; Region: Response_reg; pfam00072 357809012270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809012271 active site 357809012272 phosphorylation site [posttranslational modification] 357809012273 intermolecular recognition site; other site 357809012274 dimerization interface [polypeptide binding]; other site 357809012275 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357809012276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809012277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809012278 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 357809012279 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 357809012280 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 357809012281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809012282 Walker A/P-loop; other site 357809012283 ATP binding site [chemical binding]; other site 357809012284 Q-loop/lid; other site 357809012285 ABC transporter signature motif; other site 357809012286 Walker B; other site 357809012287 D-loop; other site 357809012288 H-loop/switch region; other site 357809012289 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 357809012290 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 357809012291 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 357809012292 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 357809012293 Beta-lactamase; Region: Beta-lactamase; pfam00144 357809012294 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357809012295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809012296 dimerization interface [polypeptide binding]; other site 357809012297 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357809012298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357809012299 dimer interface [polypeptide binding]; other site 357809012300 putative CheW interface [polypeptide binding]; other site 357809012301 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 357809012302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 357809012303 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 357809012304 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 357809012305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357809012306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809012307 active site 357809012308 phosphorylation site [posttranslational modification] 357809012309 intermolecular recognition site; other site 357809012310 dimerization interface [polypeptide binding]; other site 357809012311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357809012312 DNA binding site [nucleotide binding] 357809012313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357809012314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357809012315 dimerization interface [polypeptide binding]; other site 357809012316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357809012317 dimer interface [polypeptide binding]; other site 357809012318 phosphorylation site [posttranslational modification] 357809012319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809012320 ATP binding site [chemical binding]; other site 357809012321 Mg2+ binding site [ion binding]; other site 357809012322 G-X-G motif; other site 357809012323 S-adenosylmethionine synthetase; Validated; Region: PRK05250 357809012324 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 357809012325 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 357809012326 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 357809012327 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 357809012328 metal-binding site [ion binding] 357809012329 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 357809012330 putative homodimer interface [polypeptide binding]; other site 357809012331 putative homotetramer interface [polypeptide binding]; other site 357809012332 putative allosteric switch controlling residues; other site 357809012333 putative metal binding site [ion binding]; other site 357809012334 putative homodimer-homodimer interface [polypeptide binding]; other site 357809012335 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 357809012336 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357809012337 metal-binding site [ion binding] 357809012338 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357809012339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357809012340 motif II; other site 357809012341 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357809012342 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809012343 Zn2+ binding site [ion binding]; other site 357809012344 Mg2+ binding site [ion binding]; other site 357809012345 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 357809012346 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 357809012347 hinge; other site 357809012348 active site 357809012349 shikimate kinase; Reviewed; Region: aroK; PRK00131 357809012350 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 357809012351 ADP binding site [chemical binding]; other site 357809012352 magnesium binding site [ion binding]; other site 357809012353 putative shikimate binding site; other site 357809012354 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 357809012355 stage V sporulation protein K; Region: spore_V_K; TIGR02881 357809012356 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 357809012357 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809012358 Walker A/P-loop; other site 357809012359 ATP binding site [chemical binding]; other site 357809012360 Q-loop/lid; other site 357809012361 ABC transporter signature motif; other site 357809012362 Walker B; other site 357809012363 D-loop; other site 357809012364 H-loop/switch region; other site 357809012365 FMN-binding domain; Region: FMN_bind; pfam04205 357809012366 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 357809012367 L-aspartate oxidase; Provisional; Region: PRK06175 357809012368 Cache domain; Region: Cache_1; pfam02743 357809012369 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 357809012370 HAMP domain; Region: HAMP; pfam00672 357809012371 Histidine kinase; Region: His_kinase; pfam06580 357809012372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809012373 ATP binding site [chemical binding]; other site 357809012374 Mg2+ binding site [ion binding]; other site 357809012375 G-X-G motif; other site 357809012376 Response regulator receiver domain; Region: Response_reg; pfam00072 357809012377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809012378 active site 357809012379 phosphorylation site [posttranslational modification] 357809012380 intermolecular recognition site; other site 357809012381 dimerization interface [polypeptide binding]; other site 357809012382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357809012383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357809012384 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 357809012385 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 357809012386 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 357809012387 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 357809012388 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 357809012389 nucleoside/Zn binding site; other site 357809012390 dimer interface [polypeptide binding]; other site 357809012391 catalytic motif [active] 357809012392 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 357809012393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357809012394 FeS/SAM binding site; other site 357809012395 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357809012396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357809012397 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 357809012398 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357809012399 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809012400 ABC transporter; Region: ABC_tran_2; pfam12848 357809012401 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357809012402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809012403 Coenzyme A binding pocket [chemical binding]; other site 357809012404 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 357809012405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809012406 S-adenosylmethionine binding site [chemical binding]; other site 357809012407 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 357809012408 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 357809012409 active site 357809012410 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 357809012411 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 357809012412 putative substrate binding site [chemical binding]; other site 357809012413 putative ATP binding site [chemical binding]; other site 357809012414 Predicted transcriptional regulators [Transcription]; Region: COG1725 357809012415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357809012416 DNA-binding site [nucleotide binding]; DNA binding site 357809012417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357809012418 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357809012419 Walker A/P-loop; other site 357809012420 ATP binding site [chemical binding]; other site 357809012421 Q-loop/lid; other site 357809012422 ABC transporter signature motif; other site 357809012423 Walker B; other site 357809012424 D-loop; other site 357809012425 H-loop/switch region; other site 357809012426 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 357809012427 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 357809012428 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 357809012429 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357809012430 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357809012431 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 357809012432 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 357809012433 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 357809012434 Predicted methyltransferases [General function prediction only]; Region: COG0313 357809012435 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 357809012436 putative SAM binding site [chemical binding]; other site 357809012437 putative homodimer interface [polypeptide binding]; other site 357809012438 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 357809012439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809012440 S-adenosylmethionine binding site [chemical binding]; other site 357809012441 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 357809012442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357809012443 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 357809012444 Walker A motif; other site 357809012445 ATP binding site [chemical binding]; other site 357809012446 DNA polymerase III subunit delta'; Validated; Region: PRK07132 357809012447 Walker B motif; other site 357809012448 arginine finger; other site 357809012449 Protein of unknown function (DUF327); Region: DUF327; pfam03885 357809012450 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 357809012451 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 357809012452 active site 357809012453 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 357809012454 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357809012455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357809012456 catalytic residue [active] 357809012457 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 357809012458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357809012459 S-adenosylmethionine binding site [chemical binding]; other site 357809012460 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357809012461 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357809012462 catalytic residues [active] 357809012463 Domain of unknown function DUF20; Region: UPF0118; pfam01594 357809012464 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357809012465 DNA polymerase IV; Reviewed; Region: PRK03103 357809012466 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 357809012467 active site 357809012468 DNA binding site [nucleotide binding] 357809012469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 357809012470 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 357809012471 Probable transposase; Region: OrfB_IS605; pfam01385 357809012472 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 357809012473 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 357809012474 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 357809012475 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 357809012476 putative catalytic cysteine [active] 357809012477 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 357809012478 putative active site [active] 357809012479 metal binding site [ion binding]; metal-binding site 357809012480 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 357809012481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357809012482 Walker A/P-loop; other site 357809012483 ATP binding site [chemical binding]; other site 357809012484 Q-loop/lid; other site 357809012485 ABC transporter signature motif; other site 357809012486 Walker B; other site 357809012487 D-loop; other site 357809012488 H-loop/switch region; other site 357809012489 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 357809012490 Phosphotransferase enzyme family; Region: APH; pfam01636 357809012491 active site 357809012492 substrate binding site [chemical binding]; other site 357809012493 ATP binding site [chemical binding]; other site 357809012494 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 357809012495 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 357809012496 intersubunit interface [polypeptide binding]; other site 357809012497 active site 357809012498 Zn2+ binding site [ion binding]; other site 357809012499 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357809012500 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 357809012501 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 357809012502 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 357809012503 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357809012504 Zn2+ binding site [ion binding]; other site 357809012505 Mg2+ binding site [ion binding]; other site 357809012506 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 357809012507 ParB-like nuclease domain; Region: ParB; smart00470 357809012508 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357809012509 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357809012510 P-loop; other site 357809012511 Magnesium ion binding site [ion binding]; other site 357809012512 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357809012513 Magnesium ion binding site [ion binding]; other site 357809012514 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357809012515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357809012516 active site 357809012517 phosphorylation site [posttranslational modification] 357809012518 intermolecular recognition site; other site 357809012519 dimerization interface [polypeptide binding]; other site 357809012520 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357809012521 DNA binding residues [nucleotide binding] 357809012522 dimerization interface [polypeptide binding]; other site 357809012523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357809012524 Histidine kinase; Region: HisKA_3; pfam07730 357809012525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357809012526 ATP binding site [chemical binding]; other site 357809012527 Mg2+ binding site [ion binding]; other site 357809012528 G-X-G motif; other site 357809012529 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 357809012530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357809012531 Coenzyme A binding pocket [chemical binding]; other site 357809012532 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 357809012533 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 357809012534 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 357809012535 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 357809012536 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 357809012537 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 357809012538 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 357809012539 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 357809012540 trmE is a tRNA modification GTPase; Region: trmE; cd04164 357809012541 G1 box; other site 357809012542 GTP/Mg2+ binding site [chemical binding]; other site 357809012543 Switch I region; other site 357809012544 G2 box; other site 357809012545 Switch II region; other site 357809012546 G3 box; other site 357809012547 G4 box; other site 357809012548 G5 box; other site 357809012549 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 357809012550 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 357809012551 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 357809012552 G-X-X-G motif; other site 357809012553 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 357809012554 RxxxH motif; other site 357809012555 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 357809012556 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 357809012557 Haemolytic domain; Region: Haemolytic; pfam01809 357809012558 ribonuclease P; Reviewed; Region: rnpA; PRK00499 357809012559 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399