-- dump date 20140619_045220 -- class Genbank::misc_feature -- table misc_feature_note -- id note 931276000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 931276000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 931276000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276000004 Walker A motif; other site 931276000005 ATP binding site [chemical binding]; other site 931276000006 Walker B motif; other site 931276000007 arginine finger; other site 931276000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 931276000009 DnaA box-binding interface [nucleotide binding]; other site 931276000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 931276000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 931276000012 putative DNA binding surface [nucleotide binding]; other site 931276000013 dimer interface [polypeptide binding]; other site 931276000014 beta-clamp/clamp loader binding surface; other site 931276000015 beta-clamp/translesion DNA polymerase binding surface; other site 931276000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276000017 RNA binding surface [nucleotide binding]; other site 931276000018 recombination protein F; Reviewed; Region: recF; PRK00064 931276000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 931276000020 Walker A/P-loop; other site 931276000021 ATP binding site [chemical binding]; other site 931276000022 Q-loop/lid; other site 931276000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276000024 ABC transporter signature motif; other site 931276000025 Walker B; other site 931276000026 D-loop; other site 931276000027 H-loop/switch region; other site 931276000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 931276000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276000030 Mg2+ binding site [ion binding]; other site 931276000031 G-X-G motif; other site 931276000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 931276000033 anchoring element; other site 931276000034 dimer interface [polypeptide binding]; other site 931276000035 ATP binding site [chemical binding]; other site 931276000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 931276000037 active site 931276000038 putative metal-binding site [ion binding]; other site 931276000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 931276000040 DNA gyrase subunit A; Validated; Region: PRK05560 931276000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 931276000042 CAP-like domain; other site 931276000043 active site 931276000044 primary dimer interface [polypeptide binding]; other site 931276000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931276000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931276000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931276000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931276000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931276000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931276000051 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 931276000052 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 931276000053 HTH domain; Region: HTH_11; pfam08279 931276000054 3H domain; Region: 3H; pfam02829 931276000055 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931276000056 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931276000057 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 931276000058 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 931276000059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276000060 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 931276000061 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 931276000062 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 931276000063 Part of AAA domain; Region: AAA_19; pfam13245 931276000064 Family description; Region: UvrD_C_2; pfam13538 931276000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 931276000066 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 931276000067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276000068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276000069 dimer interface [polypeptide binding]; other site 931276000070 phosphorylation site [posttranslational modification] 931276000071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276000072 ATP binding site [chemical binding]; other site 931276000073 Mg2+ binding site [ion binding]; other site 931276000074 G-X-G motif; other site 931276000075 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 931276000076 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 931276000077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276000078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276000079 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 931276000080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276000081 Walker A/P-loop; other site 931276000082 ATP binding site [chemical binding]; other site 931276000083 Q-loop/lid; other site 931276000084 ABC transporter signature motif; other site 931276000085 Walker B; other site 931276000086 D-loop; other site 931276000087 H-loop/switch region; other site 931276000088 ABC transporter; Region: ABC_tran_2; pfam12848 931276000089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276000090 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 931276000091 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 931276000092 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 931276000093 gamma-glutamyl kinase; Provisional; Region: PRK05429 931276000094 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 931276000095 nucleotide binding site [chemical binding]; other site 931276000096 homotetrameric interface [polypeptide binding]; other site 931276000097 putative phosphate binding site [ion binding]; other site 931276000098 putative allosteric binding site; other site 931276000099 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 931276000100 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 931276000101 putative catalytic cysteine [active] 931276000102 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 931276000103 active site 931276000104 dimer interfaces [polypeptide binding]; other site 931276000105 catalytic residues [active] 931276000106 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 931276000107 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 931276000108 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 931276000109 catalytic site [active] 931276000110 subunit interface [polypeptide binding]; other site 931276000111 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 931276000112 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931276000113 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 931276000114 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 931276000115 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931276000116 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931276000117 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 931276000118 IMP binding site; other site 931276000119 dimer interface [polypeptide binding]; other site 931276000120 interdomain contacts; other site 931276000121 partial ornithine binding site; other site 931276000122 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276000123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276000124 Zn2+ binding site [ion binding]; other site 931276000125 Mg2+ binding site [ion binding]; other site 931276000126 glutamate racemase; Provisional; Region: PRK00865 931276000127 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 931276000128 active site 931276000129 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 931276000130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276000131 non-specific DNA binding site [nucleotide binding]; other site 931276000132 salt bridge; other site 931276000133 sequence-specific DNA binding site [nucleotide binding]; other site 931276000134 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 931276000135 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 931276000136 active site 931276000137 catalytic triad [active] 931276000138 Stage II sporulation protein; Region: SpoIID; pfam08486 931276000139 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 931276000140 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931276000141 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931276000142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276000143 FeS/SAM binding site; other site 931276000144 Uncharacterized membrane protein [Function unknown]; Region: COG3949 931276000145 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 931276000146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276000147 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 931276000148 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 931276000149 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276000150 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 931276000151 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 931276000152 nucleotide binding site [chemical binding]; other site 931276000153 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931276000154 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 931276000155 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 931276000156 HIGH motif; other site 931276000157 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 931276000158 active site 931276000159 KMSKS motif; other site 931276000160 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 931276000161 tRNA binding surface [nucleotide binding]; other site 931276000162 anticodon binding site; other site 931276000163 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276000164 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276000165 DNA binding site [nucleotide binding] 931276000166 domain linker motif; other site 931276000167 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276000168 dimerization interface [polypeptide binding]; other site 931276000169 ligand binding site [chemical binding]; other site 931276000170 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276000171 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 931276000172 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 931276000173 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 931276000174 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 931276000175 proline aminopeptidase P II; Provisional; Region: PRK10879 931276000176 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 931276000177 active site 931276000178 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 931276000179 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 931276000180 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 931276000181 active site 931276000182 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 931276000183 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 931276000184 HIGH motif; other site 931276000185 active site 931276000186 KMSKS motif; other site 931276000187 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 931276000188 tRNA binding surface [nucleotide binding]; other site 931276000189 anticodon binding site; other site 931276000190 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 931276000191 putative tRNA-binding site [nucleotide binding]; other site 931276000192 dimer interface [polypeptide binding]; other site 931276000193 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 931276000194 active site 931276000195 Domain of unknown function (DUF348); Region: DUF348; pfam03990 931276000196 Domain of unknown function (DUF348); Region: DUF348; pfam03990 931276000197 G5 domain; Region: G5; pfam07501 931276000198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 931276000199 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 931276000200 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 931276000201 putative active site [active] 931276000202 putative metal binding site [ion binding]; other site 931276000203 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 931276000204 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 931276000205 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 931276000206 S-adenosylmethionine binding site [chemical binding]; other site 931276000207 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 931276000208 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 931276000209 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 931276000210 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 931276000211 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 931276000212 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 931276000213 ATP cone domain; Region: ATP-cone; pfam03477 931276000214 Class III ribonucleotide reductase; Region: RNR_III; cd01675 931276000215 effector binding site; other site 931276000216 active site 931276000217 Zn binding site [ion binding]; other site 931276000218 glycine loop; other site 931276000219 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 931276000220 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 931276000221 active site 931276000222 catalytic residues [active] 931276000223 metal binding site [ion binding]; metal-binding site 931276000224 aconitate hydratase; Validated; Region: PRK07229 931276000225 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 931276000226 substrate binding site [chemical binding]; other site 931276000227 ligand binding site [chemical binding]; other site 931276000228 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 931276000229 substrate binding site [chemical binding]; other site 931276000230 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 931276000231 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 931276000232 active site 931276000233 HIGH motif; other site 931276000234 dimer interface [polypeptide binding]; other site 931276000235 KMSKS motif; other site 931276000236 S4 RNA-binding domain; Region: S4; smart00363 931276000237 RNA binding surface [nucleotide binding]; other site 931276000238 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 931276000239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276000240 FeS/SAM binding site; other site 931276000241 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 931276000242 active site 931276000243 catalytic residues [active] 931276000244 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 931276000245 active site 931276000246 DNA binding site [nucleotide binding] 931276000247 Predicted membrane protein [Function unknown]; Region: COG2246 931276000248 GtrA-like protein; Region: GtrA; pfam04138 931276000249 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 931276000250 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 931276000251 Ligand binding site; other site 931276000252 Putative Catalytic site; other site 931276000253 DXD motif; other site 931276000254 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276000255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276000256 Zn2+ binding site [ion binding]; other site 931276000257 Mg2+ binding site [ion binding]; other site 931276000258 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 931276000259 homodimer interface [polypeptide binding]; other site 931276000260 substrate-cofactor binding pocket; other site 931276000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276000262 catalytic residue [active] 931276000263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276000264 non-specific DNA binding site [nucleotide binding]; other site 931276000265 salt bridge; other site 931276000266 sequence-specific DNA binding site [nucleotide binding]; other site 931276000267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276000268 non-specific DNA binding site [nucleotide binding]; other site 931276000269 salt bridge; other site 931276000270 sequence-specific DNA binding site [nucleotide binding]; other site 931276000271 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276000272 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276000273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276000274 active site 931276000275 phosphorylation site [posttranslational modification] 931276000276 intermolecular recognition site; other site 931276000277 dimerization interface [polypeptide binding]; other site 931276000278 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276000279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276000280 S-adenosylmethionine binding site [chemical binding]; other site 931276000281 Accessory gene regulator B; Region: AgrB; pfam04647 931276000282 Staphylococcal AgrD protein; Region: AgrD; cl05477 931276000283 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 931276000284 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 931276000285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276000286 putative active site [active] 931276000287 heme pocket [chemical binding]; other site 931276000288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276000289 dimer interface [polypeptide binding]; other site 931276000290 phosphorylation site [posttranslational modification] 931276000291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276000292 ATP binding site [chemical binding]; other site 931276000293 Mg2+ binding site [ion binding]; other site 931276000294 G-X-G motif; other site 931276000295 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 931276000296 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 931276000297 putative dimer interface [polypeptide binding]; other site 931276000298 putative anticodon binding site; other site 931276000299 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 931276000300 homodimer interface [polypeptide binding]; other site 931276000301 motif 1; other site 931276000302 motif 2; other site 931276000303 active site 931276000304 motif 3; other site 931276000305 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 931276000306 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276000307 active site 931276000308 metal binding site [ion binding]; metal-binding site 931276000309 homotetramer interface [polypeptide binding]; other site 931276000310 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 931276000311 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 931276000312 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276000313 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931276000314 pur operon repressor; Provisional; Region: PRK09213 931276000315 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 931276000316 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276000317 active site 931276000318 regulatory protein SpoVG; Reviewed; Region: PRK13259 931276000319 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 931276000320 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 931276000321 Substrate binding site; other site 931276000322 Mg++ binding site; other site 931276000323 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 931276000324 active site 931276000325 substrate binding site [chemical binding]; other site 931276000326 CoA binding site [chemical binding]; other site 931276000327 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 931276000328 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 931276000329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276000330 active site 931276000331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276000332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276000333 active site 931276000334 phosphorylation site [posttranslational modification] 931276000335 intermolecular recognition site; other site 931276000336 dimerization interface [polypeptide binding]; other site 931276000337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276000338 DNA binding site [nucleotide binding] 931276000339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276000340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276000341 dimerization interface [polypeptide binding]; other site 931276000342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276000343 dimer interface [polypeptide binding]; other site 931276000344 phosphorylation site [posttranslational modification] 931276000345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276000346 ATP binding site [chemical binding]; other site 931276000347 Mg2+ binding site [ion binding]; other site 931276000348 G-X-G motif; other site 931276000349 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 931276000350 putative active site [active] 931276000351 catalytic residue [active] 931276000352 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 931276000353 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 931276000354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276000355 ATP binding site [chemical binding]; other site 931276000356 putative Mg++ binding site [ion binding]; other site 931276000357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276000358 nucleotide binding region [chemical binding]; other site 931276000359 ATP-binding site [chemical binding]; other site 931276000360 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 931276000361 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 931276000362 SurA N-terminal domain; Region: SurA_N_3; cl07813 931276000363 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 931276000364 stage V sporulation protein T; Region: spore_V_T; TIGR02851 931276000365 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 931276000366 stage V sporulation protein B; Region: spore_V_B; TIGR02900 931276000367 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 931276000368 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 931276000369 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 931276000370 putative SAM binding site [chemical binding]; other site 931276000371 putative homodimer interface [polypeptide binding]; other site 931276000372 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 931276000373 homodimer interface [polypeptide binding]; other site 931276000374 metal binding site [ion binding]; metal-binding site 931276000375 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 931276000376 homodimer interface [polypeptide binding]; other site 931276000377 active site 931276000378 putative chemical substrate binding site [chemical binding]; other site 931276000379 metal binding site [ion binding]; metal-binding site 931276000380 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 931276000381 IHF dimer interface [polypeptide binding]; other site 931276000382 IHF - DNA interface [nucleotide binding]; other site 931276000383 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276000384 RNA binding surface [nucleotide binding]; other site 931276000385 YabP family; Region: YabP; cl06766 931276000386 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 931276000387 Septum formation initiator; Region: DivIC; pfam04977 931276000388 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 931276000389 hypothetical protein; Provisional; Region: PRK05807 931276000390 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 931276000391 RNA binding site [nucleotide binding]; other site 931276000392 stage II sporulation protein E; Region: spore_II_E; TIGR02865 931276000393 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 931276000394 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 931276000395 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 931276000396 Ligand Binding Site [chemical binding]; other site 931276000397 TilS substrate C-terminal domain; Region: TilS_C; smart00977 931276000398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276000399 active site 931276000400 FtsH Extracellular; Region: FtsH_ext; pfam06480 931276000401 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 931276000402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276000403 Walker A motif; other site 931276000404 ATP binding site [chemical binding]; other site 931276000405 Walker B motif; other site 931276000406 arginine finger; other site 931276000407 Peptidase family M41; Region: Peptidase_M41; pfam01434 931276000408 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 931276000409 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 931276000410 Potassium binding sites [ion binding]; other site 931276000411 Cesium cation binding sites [ion binding]; other site 931276000412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276000413 nucleotide binding site [chemical binding]; other site 931276000414 Type III pantothenate kinase; Region: Pan_kinase; cl17198 931276000415 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 931276000416 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 931276000417 FMN binding site [chemical binding]; other site 931276000418 active site 931276000419 catalytic residues [active] 931276000420 substrate binding site [chemical binding]; other site 931276000421 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 931276000422 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 931276000423 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 931276000424 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 931276000425 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 931276000426 dimer interface [polypeptide binding]; other site 931276000427 putative anticodon binding site; other site 931276000428 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 931276000429 motif 1; other site 931276000430 active site 931276000431 motif 2; other site 931276000432 motif 3; other site 931276000433 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 931276000434 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 931276000435 dimer interface [polypeptide binding]; other site 931276000436 ssDNA binding site [nucleotide binding]; other site 931276000437 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276000438 glycyl-tRNA synthetase; Provisional; Region: PRK04173 931276000439 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 931276000440 motif 1; other site 931276000441 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 931276000442 active site 931276000443 motif 2; other site 931276000444 motif 3; other site 931276000445 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 931276000446 anticodon binding site; other site 931276000447 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 931276000448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276000449 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 931276000450 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 931276000451 metal binding site [ion binding]; metal-binding site 931276000452 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 931276000453 thymidylate kinase; Validated; Region: tmk; PRK00698 931276000454 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 931276000455 TMP-binding site; other site 931276000456 ATP-binding site [chemical binding]; other site 931276000457 Protein of unknown function (DUF970); Region: DUF970; pfam06153 931276000458 DNA polymerase III subunit delta'; Validated; Region: PRK05564 931276000459 DNA polymerase III subunit delta'; Validated; Region: PRK08485 931276000460 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 931276000461 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 931276000462 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276000463 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931276000464 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931276000465 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 931276000466 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 931276000467 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 931276000468 UvrB/uvrC motif; Region: UVR; pfam02151 931276000469 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 931276000470 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 931276000471 ADP binding site [chemical binding]; other site 931276000472 phosphagen binding site; other site 931276000473 substrate specificity loop; other site 931276000474 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 931276000475 Clp amino terminal domain; Region: Clp_N; pfam02861 931276000476 Clp amino terminal domain; Region: Clp_N; pfam02861 931276000477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276000478 Walker A motif; other site 931276000479 ATP binding site [chemical binding]; other site 931276000480 Walker B motif; other site 931276000481 arginine finger; other site 931276000482 UvrB/uvrC motif; Region: UVR; pfam02151 931276000483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276000484 Walker A motif; other site 931276000485 ATP binding site [chemical binding]; other site 931276000486 Walker B motif; other site 931276000487 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 931276000488 DNA repair protein RadA; Provisional; Region: PRK11823 931276000489 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931276000490 Walker A motif; other site 931276000491 ATP binding site [chemical binding]; other site 931276000492 Walker B motif; other site 931276000493 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 931276000494 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 931276000495 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 931276000496 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 931276000497 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 931276000498 putative active site [active] 931276000499 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 931276000500 substrate binding site; other site 931276000501 dimer interface; other site 931276000502 prolyl-tRNA synthetase; Provisional; Region: PRK09194 931276000503 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 931276000504 dimer interface [polypeptide binding]; other site 931276000505 motif 1; other site 931276000506 active site 931276000507 motif 2; other site 931276000508 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 931276000509 putative deacylase active site [active] 931276000510 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 931276000511 active site 931276000512 motif 3; other site 931276000513 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 931276000514 anticodon binding site; other site 931276000515 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 931276000516 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 931276000517 active site 931276000518 HIGH motif; other site 931276000519 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 931276000520 KMSKS motif; other site 931276000521 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 931276000522 tRNA binding surface [nucleotide binding]; other site 931276000523 anticodon binding site; other site 931276000524 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 931276000525 dimerization interface [polypeptide binding]; other site 931276000526 active site 931276000527 metal binding site [ion binding]; metal-binding site 931276000528 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 931276000529 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 931276000530 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 931276000531 YacP-like NYN domain; Region: NYN_YacP; pfam05991 931276000532 RNA polymerase factor sigma-70; Validated; Region: PRK08295 931276000533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276000534 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 931276000535 elongation factor Tu; Reviewed; Region: PRK00049 931276000536 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 931276000537 G1 box; other site 931276000538 GEF interaction site [polypeptide binding]; other site 931276000539 GTP/Mg2+ binding site [chemical binding]; other site 931276000540 Switch I region; other site 931276000541 G2 box; other site 931276000542 G3 box; other site 931276000543 Switch II region; other site 931276000544 G4 box; other site 931276000545 G5 box; other site 931276000546 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 931276000547 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 931276000548 Antibiotic Binding Site [chemical binding]; other site 931276000549 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 931276000550 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 931276000551 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 931276000552 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 931276000553 putative homodimer interface [polypeptide binding]; other site 931276000554 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 931276000555 heterodimer interface [polypeptide binding]; other site 931276000556 homodimer interface [polypeptide binding]; other site 931276000557 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 931276000558 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 931276000559 23S rRNA interface [nucleotide binding]; other site 931276000560 L7/L12 interface [polypeptide binding]; other site 931276000561 putative thiostrepton binding site; other site 931276000562 L25 interface [polypeptide binding]; other site 931276000563 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 931276000564 mRNA/rRNA interface [nucleotide binding]; other site 931276000565 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 931276000566 23S rRNA interface [nucleotide binding]; other site 931276000567 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 931276000568 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 931276000569 core dimer interface [polypeptide binding]; other site 931276000570 peripheral dimer interface [polypeptide binding]; other site 931276000571 L10 interface [polypeptide binding]; other site 931276000572 L11 interface [polypeptide binding]; other site 931276000573 putative EF-Tu interaction site [polypeptide binding]; other site 931276000574 putative EF-G interaction site [polypeptide binding]; other site 931276000575 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 931276000576 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 931276000577 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 931276000578 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 931276000579 RPB1 interaction site [polypeptide binding]; other site 931276000580 RPB10 interaction site [polypeptide binding]; other site 931276000581 RPB11 interaction site [polypeptide binding]; other site 931276000582 RPB3 interaction site [polypeptide binding]; other site 931276000583 RPB12 interaction site [polypeptide binding]; other site 931276000584 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 931276000585 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 931276000586 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 931276000587 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 931276000588 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 931276000589 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 931276000590 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 931276000591 G-loop; other site 931276000592 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 931276000593 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 931276000594 DNA binding site [nucleotide binding] 931276000595 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 931276000596 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 931276000597 S17 interaction site [polypeptide binding]; other site 931276000598 S8 interaction site; other site 931276000599 16S rRNA interaction site [nucleotide binding]; other site 931276000600 streptomycin interaction site [chemical binding]; other site 931276000601 23S rRNA interaction site [nucleotide binding]; other site 931276000602 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 931276000603 30S ribosomal protein S7; Validated; Region: PRK05302 931276000604 elongation factor G; Reviewed; Region: PRK00007 931276000605 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 931276000606 G1 box; other site 931276000607 putative GEF interaction site [polypeptide binding]; other site 931276000608 GTP/Mg2+ binding site [chemical binding]; other site 931276000609 Switch I region; other site 931276000610 G2 box; other site 931276000611 G3 box; other site 931276000612 Switch II region; other site 931276000613 G4 box; other site 931276000614 G5 box; other site 931276000615 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 931276000616 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 931276000617 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 931276000618 elongation factor Tu; Reviewed; Region: PRK00049 931276000619 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 931276000620 G1 box; other site 931276000621 GEF interaction site [polypeptide binding]; other site 931276000622 GTP/Mg2+ binding site [chemical binding]; other site 931276000623 Switch I region; other site 931276000624 G2 box; other site 931276000625 G3 box; other site 931276000626 Switch II region; other site 931276000627 G4 box; other site 931276000628 G5 box; other site 931276000629 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 931276000630 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 931276000631 Antibiotic Binding Site [chemical binding]; other site 931276000632 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 931276000633 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 931276000634 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 931276000635 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 931276000636 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 931276000637 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 931276000638 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 931276000639 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 931276000640 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 931276000641 putative translocon binding site; other site 931276000642 protein-rRNA interface [nucleotide binding]; other site 931276000643 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 931276000644 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 931276000645 G-X-X-G motif; other site 931276000646 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 931276000647 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 931276000648 23S rRNA interface [nucleotide binding]; other site 931276000649 5S rRNA interface [nucleotide binding]; other site 931276000650 putative antibiotic binding site [chemical binding]; other site 931276000651 L25 interface [polypeptide binding]; other site 931276000652 L27 interface [polypeptide binding]; other site 931276000653 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 931276000654 23S rRNA interface [nucleotide binding]; other site 931276000655 putative translocon interaction site; other site 931276000656 signal recognition particle (SRP54) interaction site; other site 931276000657 L23 interface [polypeptide binding]; other site 931276000658 trigger factor interaction site; other site 931276000659 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 931276000660 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 931276000661 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 931276000662 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 931276000663 RNA binding site [nucleotide binding]; other site 931276000664 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 931276000665 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 931276000666 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 931276000667 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 931276000668 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 931276000669 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 931276000670 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 931276000671 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 931276000672 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 931276000673 5S rRNA interface [nucleotide binding]; other site 931276000674 L27 interface [polypeptide binding]; other site 931276000675 23S rRNA interface [nucleotide binding]; other site 931276000676 L5 interface [polypeptide binding]; other site 931276000677 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 931276000678 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 931276000679 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 931276000680 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 931276000681 23S rRNA binding site [nucleotide binding]; other site 931276000682 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 931276000683 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 931276000684 SecY translocase; Region: SecY; pfam00344 931276000685 adenylate kinase; Reviewed; Region: adk; PRK00279 931276000686 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 931276000687 AMP-binding site [chemical binding]; other site 931276000688 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 931276000689 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 931276000690 active site 931276000691 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 931276000692 RNA binding site [nucleotide binding]; other site 931276000693 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 931276000694 rRNA binding site [nucleotide binding]; other site 931276000695 predicted 30S ribosome binding site; other site 931276000696 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 931276000697 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 931276000698 30S ribosomal protein S13; Region: bact_S13; TIGR03631 931276000699 30S ribosomal protein S11; Validated; Region: PRK05309 931276000700 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 931276000701 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 931276000702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276000703 RNA binding surface [nucleotide binding]; other site 931276000704 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 931276000705 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 931276000706 alphaNTD homodimer interface [polypeptide binding]; other site 931276000707 alphaNTD - beta interaction site [polypeptide binding]; other site 931276000708 alphaNTD - beta' interaction site [polypeptide binding]; other site 931276000709 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 931276000710 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 931276000711 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 931276000712 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931276000713 Walker A/P-loop; other site 931276000714 ATP binding site [chemical binding]; other site 931276000715 Q-loop/lid; other site 931276000716 ABC transporter signature motif; other site 931276000717 Walker B; other site 931276000718 D-loop; other site 931276000719 H-loop/switch region; other site 931276000720 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 931276000721 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931276000722 Walker A/P-loop; other site 931276000723 ATP binding site [chemical binding]; other site 931276000724 Q-loop/lid; other site 931276000725 ABC transporter signature motif; other site 931276000726 Walker B; other site 931276000727 D-loop; other site 931276000728 H-loop/switch region; other site 931276000729 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 931276000730 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 931276000731 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 931276000732 dimerization interface 3.5A [polypeptide binding]; other site 931276000733 active site 931276000734 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 931276000735 23S rRNA interface [nucleotide binding]; other site 931276000736 L3 interface [polypeptide binding]; other site 931276000737 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 931276000738 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 931276000739 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931276000740 active site 931276000741 metal binding site [ion binding]; metal-binding site 931276000742 fumarate hydratase; Provisional; Region: PRK06246 931276000743 Fumarase C-terminus; Region: Fumerase_C; cl00795 931276000744 TPR repeat; Region: TPR_11; pfam13414 931276000745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276000746 binding surface 931276000747 TPR motif; other site 931276000748 TPR repeat; Region: TPR_11; pfam13414 931276000749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276000750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276000751 active site 931276000752 phosphorylation site [posttranslational modification] 931276000753 intermolecular recognition site; other site 931276000754 dimerization interface [polypeptide binding]; other site 931276000755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276000756 DNA binding site [nucleotide binding] 931276000757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276000758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276000759 dimer interface [polypeptide binding]; other site 931276000760 phosphorylation site [posttranslational modification] 931276000761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276000762 ATP binding site [chemical binding]; other site 931276000763 Mg2+ binding site [ion binding]; other site 931276000764 G-X-G motif; other site 931276000765 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 931276000766 Class I ribonucleotide reductase; Region: RNR_I; cd01679 931276000767 active site 931276000768 dimer interface [polypeptide binding]; other site 931276000769 catalytic residues [active] 931276000770 effector binding site; other site 931276000771 R2 peptide binding site; other site 931276000772 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 931276000773 dimer interface [polypeptide binding]; other site 931276000774 putative radical transfer pathway; other site 931276000775 diiron center [ion binding]; other site 931276000776 tyrosyl radical; other site 931276000777 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 931276000778 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 931276000779 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 931276000780 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 931276000781 Tetratricopeptide repeat; Region: TPR_16; pfam13432 931276000782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931276000783 binding surface 931276000784 TPR motif; other site 931276000785 TPR repeat; Region: TPR_11; pfam13414 931276000786 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 931276000787 Uncharacterized conserved protein [Function unknown]; Region: COG1624 931276000788 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 931276000789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 931276000790 YbbR-like protein; Region: YbbR; pfam07949 931276000791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 931276000792 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 931276000793 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 931276000794 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 931276000795 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 931276000796 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 931276000797 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931276000798 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 931276000799 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 931276000800 phosphate butyryltransferase; Validated; Region: PRK05805 931276000801 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276000802 nucleotide binding site [chemical binding]; other site 931276000803 Acetokinase family; Region: Acetate_kinase; cl17229 931276000804 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 931276000805 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 931276000806 Ligand binding site; other site 931276000807 Putative Catalytic site; other site 931276000808 DXD motif; other site 931276000809 GtrA-like protein; Region: GtrA; pfam04138 931276000810 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276000811 Zn2+ binding site [ion binding]; other site 931276000812 Mg2+ binding site [ion binding]; other site 931276000813 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 931276000814 dihydropteroate synthase; Region: DHPS; TIGR01496 931276000815 substrate binding pocket [chemical binding]; other site 931276000816 dimer interface [polypeptide binding]; other site 931276000817 inhibitor binding site; inhibition site 931276000818 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 931276000819 homooctamer interface [polypeptide binding]; other site 931276000820 active site 931276000821 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 931276000822 catalytic center binding site [active] 931276000823 ATP binding site [chemical binding]; other site 931276000824 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 931276000825 Trp repressor protein; Region: Trp_repressor; cl17266 931276000826 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 931276000827 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 931276000828 active site 931276000829 substrate binding site [chemical binding]; other site 931276000830 metal binding site [ion binding]; metal-binding site 931276000831 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 931276000832 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 931276000833 Protein of unknown function, DUF624; Region: DUF624; pfam04854 931276000834 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 931276000835 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 931276000836 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 931276000837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276000838 dimer interface [polypeptide binding]; other site 931276000839 conserved gate region; other site 931276000840 ABC-ATPase subunit interface; other site 931276000841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276000842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276000843 dimer interface [polypeptide binding]; other site 931276000844 conserved gate region; other site 931276000845 ABC-ATPase subunit interface; other site 931276000846 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 931276000847 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276000848 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276000849 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276000850 putative alpha-glucosidase; Provisional; Region: PRK10658 931276000851 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 931276000852 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 931276000853 active site 931276000854 homotrimer interface [polypeptide binding]; other site 931276000855 catalytic site [active] 931276000856 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 931276000857 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 931276000858 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 931276000859 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 931276000860 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 931276000861 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276000862 dimerization interface [polypeptide binding]; other site 931276000863 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931276000864 Histidine kinase; Region: His_kinase; pfam06580 931276000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276000866 ATP binding site [chemical binding]; other site 931276000867 Mg2+ binding site [ion binding]; other site 931276000868 G-X-G motif; other site 931276000869 Response regulator receiver domain; Region: Response_reg; pfam00072 931276000870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276000871 active site 931276000872 phosphorylation site [posttranslational modification] 931276000873 intermolecular recognition site; other site 931276000874 dimerization interface [polypeptide binding]; other site 931276000875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276000876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276000877 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 931276000878 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 931276000879 putative valine binding site [chemical binding]; other site 931276000880 dimer interface [polypeptide binding]; other site 931276000881 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 931276000882 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 931276000883 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 931276000884 active site 931276000885 catalytic residues [active] 931276000886 metal binding site [ion binding]; metal-binding site 931276000887 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 931276000888 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 931276000889 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 931276000890 substrate binding site [chemical binding]; other site 931276000891 ligand binding site [chemical binding]; other site 931276000892 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 931276000893 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 931276000894 substrate binding site [chemical binding]; other site 931276000895 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 931276000896 tartrate dehydrogenase; Region: TTC; TIGR02089 931276000897 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 931276000898 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 931276000899 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931276000900 PYR/PP interface [polypeptide binding]; other site 931276000901 dimer interface [polypeptide binding]; other site 931276000902 TPP binding site [chemical binding]; other site 931276000903 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 931276000904 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 931276000905 TPP-binding site [chemical binding]; other site 931276000906 dimer interface [polypeptide binding]; other site 931276000907 ketol-acid reductoisomerase; Provisional; Region: PRK05479 931276000908 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 931276000909 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 931276000910 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 931276000911 GIY-YIG motif/motif A; other site 931276000912 putative active site [active] 931276000913 putative metal binding site [ion binding]; other site 931276000914 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276000915 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276000916 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 931276000917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276000918 dimer interface [polypeptide binding]; other site 931276000919 conserved gate region; other site 931276000920 putative PBP binding loops; other site 931276000921 ABC-ATPase subunit interface; other site 931276000922 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276000923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276000924 dimer interface [polypeptide binding]; other site 931276000925 conserved gate region; other site 931276000926 putative PBP binding loops; other site 931276000927 ABC-ATPase subunit interface; other site 931276000928 4-alpha-glucanotransferase; Provisional; Region: PRK14508 931276000929 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276000930 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276000931 DNA binding site [nucleotide binding] 931276000932 domain linker motif; other site 931276000933 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 931276000934 putative dimerization interface [polypeptide binding]; other site 931276000935 putative ligand binding site [chemical binding]; other site 931276000936 HAMP domain; Region: HAMP; pfam00672 931276000937 dimerization interface [polypeptide binding]; other site 931276000938 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276000939 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276000940 dimer interface [polypeptide binding]; other site 931276000941 putative CheW interface [polypeptide binding]; other site 931276000942 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 931276000943 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 931276000944 putative active site [active] 931276000945 putative metal binding site [ion binding]; other site 931276000946 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276000947 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276000948 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276000949 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276000950 Walker A/P-loop; other site 931276000951 ATP binding site [chemical binding]; other site 931276000952 Q-loop/lid; other site 931276000953 ABC transporter signature motif; other site 931276000954 Walker B; other site 931276000955 D-loop; other site 931276000956 H-loop/switch region; other site 931276000957 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276000958 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931276000959 FtsX-like permease family; Region: FtsX; pfam02687 931276000960 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 931276000961 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 931276000962 active site 931276000963 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 931276000964 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276000965 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276000966 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 931276000967 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 931276000968 homodimer interface [polypeptide binding]; other site 931276000969 substrate-cofactor binding pocket; other site 931276000970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276000971 catalytic residue [active] 931276000972 cystathionine beta-lyase; Provisional; Region: PRK08064 931276000973 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 931276000974 homodimer interface [polypeptide binding]; other site 931276000975 substrate-cofactor binding pocket; other site 931276000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276000977 catalytic residue [active] 931276000978 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276000979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276000980 putative DNA binding site [nucleotide binding]; other site 931276000981 putative Zn2+ binding site [ion binding]; other site 931276000982 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 931276000983 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 931276000984 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 931276000985 glutaminase active site [active] 931276000986 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 931276000987 dimer interface [polypeptide binding]; other site 931276000988 active site 931276000989 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 931276000990 dimer interface [polypeptide binding]; other site 931276000991 active site 931276000992 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 931276000993 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 931276000994 nucleophile elbow; other site 931276000995 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 931276000996 classical (c) SDRs; Region: SDR_c; cd05233 931276000997 NAD(P) binding site [chemical binding]; other site 931276000998 active site 931276000999 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 931276001000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276001001 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276001002 Phosphopantetheine attachment site; Region: PP-binding; cl09936 931276001003 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931276001004 hypothetical protein; Validated; Region: PRK07080 931276001005 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 931276001006 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 931276001007 active site 931276001008 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 931276001009 Ligand binding site [chemical binding]; other site 931276001010 Electron transfer flavoprotein domain; Region: ETF; pfam01012 931276001011 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931276001012 Ligand Binding Site [chemical binding]; other site 931276001013 Electron transfer flavoprotein domain; Region: ETF; smart00893 931276001014 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931276001015 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 931276001016 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 931276001017 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 931276001018 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 931276001019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276001020 Walker A/P-loop; other site 931276001021 ATP binding site [chemical binding]; other site 931276001022 Q-loop/lid; other site 931276001023 ABC transporter signature motif; other site 931276001024 Walker B; other site 931276001025 D-loop; other site 931276001026 H-loop/switch region; other site 931276001027 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 931276001028 putative active site [active] 931276001029 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 931276001030 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 931276001031 acyl-activating enzyme (AAE) consensus motif; other site 931276001032 AMP binding site [chemical binding]; other site 931276001033 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001034 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 931276001035 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 931276001036 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931276001037 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 931276001038 acyl-activating enzyme (AAE) consensus motif; other site 931276001039 AMP binding site [chemical binding]; other site 931276001040 active site 931276001041 acyl-activating enzyme (AAE) consensus motif; other site 931276001042 CoA binding site [chemical binding]; other site 931276001043 Phosphopantetheine attachment site; Region: PP-binding; cl09936 931276001044 Peptidase family U32; Region: Peptidase_U32; cl03113 931276001045 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 931276001046 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 931276001047 glutamine binding [chemical binding]; other site 931276001048 catalytic triad [active] 931276001049 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 931276001050 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 931276001051 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 931276001052 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 931276001053 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 931276001054 homodimer interface [polypeptide binding]; other site 931276001055 substrate-cofactor binding pocket; other site 931276001056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276001057 catalytic residue [active] 931276001058 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276001059 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931276001060 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 931276001061 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276001062 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276001063 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276001064 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 931276001065 Helix-turn-helix domain; Region: HTH_18; pfam12833 931276001066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276001067 HutD; Region: HutD; pfam05962 931276001068 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 931276001069 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 931276001070 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 931276001071 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 931276001072 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 931276001073 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 931276001074 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 931276001075 active site 931276001076 dimer interface [polypeptide binding]; other site 931276001077 motif 1; other site 931276001078 motif 2; other site 931276001079 motif 3; other site 931276001080 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 931276001081 anticodon binding site; other site 931276001082 Cache domain; Region: Cache_1; pfam02743 931276001083 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276001084 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276001085 dimer interface [polypeptide binding]; other site 931276001086 putative CheW interface [polypeptide binding]; other site 931276001087 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 931276001088 active site 931276001089 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 931276001090 homotrimer interaction site [polypeptide binding]; other site 931276001091 zinc binding site [ion binding]; other site 931276001092 CDP-binding sites; other site 931276001093 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 931276001094 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276001095 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 931276001096 putative active site [active] 931276001097 putative metal binding site [ion binding]; other site 931276001098 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 931276001099 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 931276001100 biotin synthase; Provisional; Region: PRK07094 931276001101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276001102 FeS/SAM binding site; other site 931276001103 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 931276001104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276001105 salt bridge; other site 931276001106 non-specific DNA binding site [nucleotide binding]; other site 931276001107 sequence-specific DNA binding site [nucleotide binding]; other site 931276001108 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 931276001109 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 931276001110 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 931276001111 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276001112 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 931276001113 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 931276001114 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931276001115 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 931276001116 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 931276001117 active site 931276001118 nucleophile elbow; other site 931276001119 Transcriptional regulators [Transcription]; Region: FadR; COG2186 931276001120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276001121 DNA-binding site [nucleotide binding]; DNA binding site 931276001122 FCD domain; Region: FCD; pfam07729 931276001123 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 931276001124 L-lactate permease; Region: Lactate_perm; cl00701 931276001125 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 931276001126 Ligand binding site [chemical binding]; other site 931276001127 Electron transfer flavoprotein domain; Region: ETF; pfam01012 931276001128 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 931276001129 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931276001130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 931276001131 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931276001132 FAD binding domain; Region: FAD_binding_4; pfam01565 931276001133 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 931276001134 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 931276001135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276001136 DNA binding residues [nucleotide binding] 931276001137 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931276001138 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 931276001139 peptide binding site [polypeptide binding]; other site 931276001140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931276001141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276001142 dimer interface [polypeptide binding]; other site 931276001143 conserved gate region; other site 931276001144 putative PBP binding loops; other site 931276001145 ABC-ATPase subunit interface; other site 931276001146 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 931276001147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276001148 dimer interface [polypeptide binding]; other site 931276001149 conserved gate region; other site 931276001150 putative PBP binding loops; other site 931276001151 ABC-ATPase subunit interface; other site 931276001152 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931276001153 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276001154 Walker A/P-loop; other site 931276001155 ATP binding site [chemical binding]; other site 931276001156 Q-loop/lid; other site 931276001157 ABC transporter signature motif; other site 931276001158 Walker B; other site 931276001159 D-loop; other site 931276001160 H-loop/switch region; other site 931276001161 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276001162 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 931276001163 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276001164 Walker A/P-loop; other site 931276001165 ATP binding site [chemical binding]; other site 931276001166 Q-loop/lid; other site 931276001167 ABC transporter signature motif; other site 931276001168 Walker B; other site 931276001169 D-loop; other site 931276001170 H-loop/switch region; other site 931276001171 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276001172 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276001174 active site 931276001175 phosphorylation site [posttranslational modification] 931276001176 intermolecular recognition site; other site 931276001177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276001178 dimerization interface [polypeptide binding]; other site 931276001179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276001180 dimer interface [polypeptide binding]; other site 931276001181 phosphorylation site [posttranslational modification] 931276001182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276001183 ATP binding site [chemical binding]; other site 931276001184 Mg2+ binding site [ion binding]; other site 931276001185 G-X-G motif; other site 931276001186 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 931276001187 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931276001188 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 931276001189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276001190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931276001191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931276001192 active site 931276001193 Response regulator receiver domain; Region: Response_reg; pfam00072 931276001194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276001195 active site 931276001196 phosphorylation site [posttranslational modification] 931276001197 intermolecular recognition site; other site 931276001198 dimerization interface [polypeptide binding]; other site 931276001199 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 931276001200 putative binding surface; other site 931276001201 active site 931276001202 PAS domain; Region: PAS_9; pfam13426 931276001203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276001204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276001205 dimer interface [polypeptide binding]; other site 931276001206 phosphorylation site [posttranslational modification] 931276001207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276001208 ATP binding site [chemical binding]; other site 931276001209 Mg2+ binding site [ion binding]; other site 931276001210 G-X-G motif; other site 931276001211 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276001212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276001213 active site 931276001214 phosphorylation site [posttranslational modification] 931276001215 intermolecular recognition site; other site 931276001216 dimerization interface [polypeptide binding]; other site 931276001217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276001218 active site 931276001219 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 931276001220 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 931276001221 Substrate binding site; other site 931276001222 Cupin domain; Region: Cupin_2; cl17218 931276001223 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 931276001224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276001225 active site 931276001226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276001227 Walker A/P-loop; other site 931276001228 ATP binding site [chemical binding]; other site 931276001229 Q-loop/lid; other site 931276001230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276001231 ABC transporter signature motif; other site 931276001232 Walker B; other site 931276001233 D-loop; other site 931276001234 H-loop/switch region; other site 931276001235 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 931276001236 AAA domain; Region: AAA_21; pfam13304 931276001237 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931276001238 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276001239 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 931276001240 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 931276001241 acyl-activating enzyme (AAE) consensus motif; other site 931276001242 active site 931276001243 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001244 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001245 active site 931276001246 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001247 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001248 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001249 active site 931276001250 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 931276001251 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 931276001252 putative NADP binding site [chemical binding]; other site 931276001253 active site 931276001254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001255 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001256 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001257 active site 931276001258 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 931276001259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276001260 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001261 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 931276001262 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001263 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001264 active site 931276001265 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 931276001266 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 931276001267 putative NADP binding site [chemical binding]; other site 931276001268 active site 931276001269 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001270 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001271 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001272 active site 931276001273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001274 Condensation domain; Region: Condensation; pfam00668 931276001275 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276001276 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 931276001277 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 931276001278 acyl-activating enzyme (AAE) consensus motif; other site 931276001279 AMP binding site [chemical binding]; other site 931276001280 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001281 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001282 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001283 active site 931276001284 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 931276001285 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 931276001286 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 931276001287 putative NADP binding site [chemical binding]; other site 931276001288 active site 931276001289 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001291 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001292 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001293 active site 931276001294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001295 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 931276001296 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 931276001297 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 931276001298 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931276001299 FtsX-like permease family; Region: FtsX; pfam02687 931276001300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276001301 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276001302 Walker A/P-loop; other site 931276001303 ATP binding site [chemical binding]; other site 931276001304 Q-loop/lid; other site 931276001305 ABC transporter signature motif; other site 931276001306 Walker B; other site 931276001307 D-loop; other site 931276001308 H-loop/switch region; other site 931276001309 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276001310 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276001311 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276001312 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276001313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276001314 S-adenosylmethionine binding site [chemical binding]; other site 931276001315 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 931276001316 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 931276001317 NAD(P) binding site [chemical binding]; other site 931276001318 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 931276001319 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 931276001320 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 931276001321 acyl-activating enzyme (AAE) consensus motif; other site 931276001322 AMP binding site [chemical binding]; other site 931276001323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001324 Condensation domain; Region: Condensation; pfam00668 931276001325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276001326 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 931276001327 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 931276001328 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931276001329 acyl-activating enzyme (AAE) consensus motif; other site 931276001330 AMP binding site [chemical binding]; other site 931276001331 active site 931276001332 CoA binding site [chemical binding]; other site 931276001333 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 931276001334 putative NADP binding site [chemical binding]; other site 931276001335 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 931276001336 active site 931276001337 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001338 thioester reductase domain; Region: Thioester-redct; TIGR01746 931276001339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276001340 NAD(P) binding site [chemical binding]; other site 931276001341 active site 931276001342 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001343 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001344 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001345 active site 931276001346 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 931276001347 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 931276001348 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931276001350 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 931276001351 acyl-activating enzyme (AAE) consensus motif; other site 931276001352 AMP binding site [chemical binding]; other site 931276001353 active site 931276001354 CoA binding site [chemical binding]; other site 931276001355 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 931276001356 putative NADP binding site [chemical binding]; other site 931276001357 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 931276001358 active site 931276001359 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001360 Condensation domain; Region: Condensation; pfam00668 931276001361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276001362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 931276001363 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001364 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276001365 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 931276001366 active site 931276001367 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276001368 Condensation domain; Region: Condensation; pfam00668 931276001369 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276001370 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 931276001371 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 931276001372 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 931276001373 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276001374 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 931276001375 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276001376 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276001377 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 931276001378 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276001379 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 931276001380 protein-splicing catalytic site; other site 931276001381 thioester formation/cholesterol transfer; other site 931276001382 Pretoxin HINT domain; Region: PT-HINT; pfam07591 931276001383 putative transposase OrfB; Reviewed; Region: PHA02517 931276001384 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931276001385 Integrase core domain; Region: rve; pfam00665 931276001386 Integrase core domain; Region: rve_3; cl15866 931276001387 Transposase; Region: HTH_Tnp_1; cl17663 931276001388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931276001389 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 931276001390 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 931276001391 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 931276001392 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276001393 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 931276001394 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 931276001395 catalytic residues [active] 931276001396 catalytic nucleophile [active] 931276001397 Recombinase; Region: Recombinase; pfam07508 931276001398 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 931276001399 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 931276001400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276001401 Cupin domain; Region: Cupin_2; cl17218 931276001402 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 931276001403 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 931276001404 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 931276001405 CoA binding domain; Region: CoA_binding; pfam02629 931276001406 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 931276001407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 931276001408 substrate binding site [chemical binding]; other site 931276001409 oxyanion hole (OAH) forming residues; other site 931276001410 trimer interface [polypeptide binding]; other site 931276001411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 931276001412 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 931276001413 FAD binding site [chemical binding]; other site 931276001414 homotetramer interface [polypeptide binding]; other site 931276001415 substrate binding pocket [chemical binding]; other site 931276001416 catalytic base [active] 931276001417 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 931276001418 Ligand binding site [chemical binding]; other site 931276001419 Electron transfer flavoprotein domain; Region: ETF; pfam01012 931276001420 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931276001421 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 931276001422 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931276001423 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 931276001424 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 931276001425 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 931276001426 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931276001427 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 931276001428 putative active site [active] 931276001429 metal binding site [ion binding]; metal-binding site 931276001430 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 931276001431 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 931276001432 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 931276001433 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 931276001434 minor groove reading motif; other site 931276001435 helix-hairpin-helix signature motif; other site 931276001436 substrate binding pocket [chemical binding]; other site 931276001437 active site 931276001438 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 931276001439 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276001440 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931276001441 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 931276001442 oligomerisation interface [polypeptide binding]; other site 931276001443 mobile loop; other site 931276001444 roof hairpin; other site 931276001445 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 931276001446 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 931276001447 ring oligomerisation interface [polypeptide binding]; other site 931276001448 ATP/Mg binding site [chemical binding]; other site 931276001449 stacking interactions; other site 931276001450 hinge regions; other site 931276001451 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 931276001452 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 931276001453 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931276001454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 931276001455 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 931276001456 active site 931276001457 GMP synthase; Reviewed; Region: guaA; PRK00074 931276001458 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 931276001459 AMP/PPi binding site [chemical binding]; other site 931276001460 candidate oxyanion hole; other site 931276001461 catalytic triad [active] 931276001462 potential glutamine specificity residues [chemical binding]; other site 931276001463 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 931276001464 ATP Binding subdomain [chemical binding]; other site 931276001465 Ligand Binding sites [chemical binding]; other site 931276001466 Dimerization subdomain; other site 931276001467 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 931276001468 active site 931276001469 catalytic triad [active] 931276001470 oxyanion hole [active] 931276001471 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 931276001472 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931276001473 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276001474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276001475 Walker A/P-loop; other site 931276001476 ATP binding site [chemical binding]; other site 931276001477 Q-loop/lid; other site 931276001478 ABC transporter signature motif; other site 931276001479 Walker B; other site 931276001480 D-loop; other site 931276001481 H-loop/switch region; other site 931276001482 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 931276001483 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 931276001484 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 931276001485 active site 931276001486 dimer interface [polypeptide binding]; other site 931276001487 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 931276001488 dimer interface [polypeptide binding]; other site 931276001489 active site 931276001490 hypothetical protein; Validated; Region: PRK00124 931276001491 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 931276001492 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 931276001493 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 931276001494 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 931276001495 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 931276001496 N-acetyl-D-glucosamine binding site [chemical binding]; other site 931276001497 catalytic residue [active] 931276001498 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 931276001499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276001500 RNA binding surface [nucleotide binding]; other site 931276001501 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 931276001502 active site 931276001503 uracil binding [chemical binding]; other site 931276001504 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 931276001505 dimer interface [polypeptide binding]; other site 931276001506 FMN binding site [chemical binding]; other site 931276001507 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276001508 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276001509 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931276001510 MarR family; Region: MarR_2; pfam12802 931276001511 NifU-like domain; Region: NifU; cl00484 931276001512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276001513 dimerization interface [polypeptide binding]; other site 931276001514 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276001515 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276001516 dimer interface [polypeptide binding]; other site 931276001517 putative CheW interface [polypeptide binding]; other site 931276001518 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 931276001519 Part of AAA domain; Region: AAA_19; pfam13245 931276001520 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 931276001521 protein-splicing catalytic site; other site 931276001522 thioester formation/cholesterol transfer; other site 931276001523 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 931276001524 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 931276001525 thioester formation/cholesterol transfer; other site 931276001526 protein-splicing catalytic site; other site 931276001527 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 931276001528 Family description; Region: UvrD_C_2; pfam13538 931276001529 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 931276001530 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 931276001531 nucleotide binding pocket [chemical binding]; other site 931276001532 K-X-D-G motif; other site 931276001533 catalytic site [active] 931276001534 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 931276001535 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 931276001536 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 931276001537 Dimer interface [polypeptide binding]; other site 931276001538 BRCT sequence motif; other site 931276001539 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 931276001540 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 931276001541 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 931276001542 active site 931276001543 dimerization interface [polypeptide binding]; other site 931276001544 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 931276001545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276001546 active site 931276001547 metal binding site [ion binding]; metal-binding site 931276001548 homotetramer interface [polypeptide binding]; other site 931276001549 Fic/DOC family; Region: Fic; pfam02661 931276001550 Fic/DOC family; Region: Fic; cl00960 931276001551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276001552 short chain dehydrogenase; Provisional; Region: PRK08251 931276001553 NAD(P) binding site [chemical binding]; other site 931276001554 active site 931276001555 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276001556 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276001557 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276001558 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276001559 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 931276001560 active site 931276001561 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 931276001562 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276001563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276001564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276001565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276001566 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 931276001567 putative active site [active] 931276001568 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 931276001569 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 931276001570 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 931276001571 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 931276001572 active site 931276001573 Zn binding site [ion binding]; other site 931276001574 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276001575 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 931276001576 NodB motif; other site 931276001577 active site 931276001578 catalytic site [active] 931276001579 Zn binding site [ion binding]; other site 931276001580 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 931276001581 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 931276001582 Histidine kinase; Region: HisKA_3; pfam07730 931276001583 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 931276001584 ATP binding site [chemical binding]; other site 931276001585 Mg2+ binding site [ion binding]; other site 931276001586 G-X-G motif; other site 931276001587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276001588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276001589 active site 931276001590 phosphorylation site [posttranslational modification] 931276001591 intermolecular recognition site; other site 931276001592 dimerization interface [polypeptide binding]; other site 931276001593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276001594 DNA binding residues [nucleotide binding] 931276001595 dimerization interface [polypeptide binding]; other site 931276001596 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276001597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276001598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276001599 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276001600 EamA-like transporter family; Region: EamA; pfam00892 931276001601 EamA-like transporter family; Region: EamA; pfam00892 931276001602 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276001603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276001604 Walker A/P-loop; other site 931276001605 ATP binding site [chemical binding]; other site 931276001606 Q-loop/lid; other site 931276001607 ABC transporter signature motif; other site 931276001608 Walker B; other site 931276001609 D-loop; other site 931276001610 H-loop/switch region; other site 931276001611 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931276001612 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931276001613 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931276001614 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931276001615 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931276001616 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 931276001617 Sulfatase; Region: Sulfatase; pfam00884 931276001618 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 931276001619 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 931276001620 CPxP motif; other site 931276001621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276001622 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 931276001623 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 931276001624 active site 931276001625 catalytic triad [active] 931276001626 oxyanion hole [active] 931276001627 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 931276001628 UGMP family protein; Validated; Region: PRK09604 931276001629 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 931276001630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276001631 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 931276001632 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 931276001633 protein binding site [polypeptide binding]; other site 931276001634 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276001635 methionine cluster; other site 931276001636 active site 931276001637 phosphorylation site [posttranslational modification] 931276001638 metal binding site [ion binding]; metal-binding site 931276001639 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276001640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276001641 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 931276001642 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 931276001643 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 931276001644 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 931276001645 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 931276001646 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 931276001647 substrate binding site [chemical binding]; other site 931276001648 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276001649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276001650 Walker A/P-loop; other site 931276001651 ATP binding site [chemical binding]; other site 931276001652 Q-loop/lid; other site 931276001653 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276001654 ABC transporter; Region: ABC_tran_2; pfam12848 931276001655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276001656 Mor transcription activator family; Region: Mor; cl02360 931276001657 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 931276001658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276001659 active site 931276001660 HIGH motif; other site 931276001661 nucleotide binding site [chemical binding]; other site 931276001662 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 931276001663 active site 931276001664 KMSKS motif; other site 931276001665 flagellin; Provisional; Region: PRK12806 931276001666 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931276001667 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 931276001668 Heme NO binding; Region: HNOB; pfam07700 931276001669 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276001670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276001671 dimer interface [polypeptide binding]; other site 931276001672 putative CheW interface [polypeptide binding]; other site 931276001673 Putative esterase; Region: Esterase; pfam00756 931276001674 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 931276001675 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 931276001676 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 931276001677 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 931276001678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931276001679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276001680 Coenzyme A binding pocket [chemical binding]; other site 931276001681 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 931276001682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276001683 active site 931276001684 HIGH motif; other site 931276001685 nucleotide binding site [chemical binding]; other site 931276001686 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 931276001687 KMSKS motif; other site 931276001688 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 931276001689 Right handed beta helix region; Region: Beta_helix; pfam13229 931276001690 Response regulator receiver domain; Region: Response_reg; pfam00072 931276001691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276001692 active site 931276001693 phosphorylation site [posttranslational modification] 931276001694 intermolecular recognition site; other site 931276001695 dimerization interface [polypeptide binding]; other site 931276001696 LytTr DNA-binding domain; Region: LytTR; pfam04397 931276001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 931276001698 Accessory gene regulator B; Region: AgrB; pfam04647 931276001699 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 931276001700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276001701 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 931276001702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 931276001703 active site 931276001704 ATP binding site [chemical binding]; other site 931276001705 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 931276001706 active site 931276001707 ATP binding site [chemical binding]; other site 931276001708 substrate binding site [chemical binding]; other site 931276001709 YabG peptidase U57; Region: Peptidase_U57; pfam05582 931276001710 short chain dehydrogenase; Validated; Region: PRK06182 931276001711 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 931276001712 NADP binding site [chemical binding]; other site 931276001713 active site 931276001714 steroid binding site; other site 931276001715 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276001716 classical (c) SDRs; Region: SDR_c; cd05233 931276001717 NAD(P) binding site [chemical binding]; other site 931276001718 active site 931276001719 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 931276001720 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276001721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276001722 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 931276001723 active site 931276001724 NTP binding site [chemical binding]; other site 931276001725 metal binding triad [ion binding]; metal-binding site 931276001726 antibiotic binding site [chemical binding]; other site 931276001727 Protein of unknown function DUF86; Region: DUF86; cl01031 931276001728 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 931276001729 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276001730 active site 931276001731 metal binding site [ion binding]; metal-binding site 931276001732 YibE/F-like protein; Region: YibE_F; pfam07907 931276001733 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276001734 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 931276001735 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 931276001736 dimer interface [polypeptide binding]; other site 931276001737 motif 1; other site 931276001738 active site 931276001739 motif 2; other site 931276001740 motif 3; other site 931276001741 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 931276001742 anticodon binding site; other site 931276001743 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276001744 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276001745 substrate binding pocket [chemical binding]; other site 931276001746 membrane-bound complex binding site; other site 931276001747 hinge residues; other site 931276001748 Uncharacterized conserved protein [Function unknown]; Region: COG1359 931276001749 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276001750 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276001751 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276001752 dimer interface [polypeptide binding]; other site 931276001753 putative CheW interface [polypeptide binding]; other site 931276001754 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 931276001755 Predicted membrane protein [Function unknown]; Region: COG1511 931276001756 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931276001757 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 931276001758 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 931276001759 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 931276001760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276001761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276001762 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276001763 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 931276001764 classical (c) SDRs; Region: SDR_c; cd05233 931276001765 NAD(P) binding site [chemical binding]; other site 931276001766 active site 931276001767 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276001768 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931276001769 DNA binding residues [nucleotide binding] 931276001770 putative dimer interface [polypeptide binding]; other site 931276001771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276001772 FeS/SAM binding site; other site 931276001773 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931276001774 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 931276001775 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 931276001776 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276001777 DNA binding residues [nucleotide binding] 931276001778 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 931276001779 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931276001780 catalytic core [active] 931276001781 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276001782 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276001783 RNA polymerase factor sigma-70; Validated; Region: PRK06811 931276001784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276001785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276001786 DNA binding residues [nucleotide binding] 931276001787 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 931276001788 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931276001789 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931276001790 putative active site [active] 931276001791 putative NTP binding site [chemical binding]; other site 931276001792 putative nucleic acid binding site [nucleotide binding]; other site 931276001793 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931276001794 methionine sulfoxide reductase A; Provisional; Region: PRK14054 931276001795 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276001796 beta-galactosidase; Region: BGL; TIGR03356 931276001797 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 931276001798 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 931276001799 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 931276001800 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 931276001801 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 931276001802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 931276001803 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 931276001804 proposed catalytic triad [active] 931276001805 active site nucleophile [active] 931276001806 cyanophycin synthetase; Provisional; Region: PRK14016 931276001807 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931276001808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276001809 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931276001810 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 931276001811 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 931276001812 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 931276001813 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 931276001814 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 931276001815 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 931276001816 Ligand Binding Site [chemical binding]; other site 931276001817 Domain of unknown function (DUF814); Region: DUF814; pfam05670 931276001818 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 931276001819 CTP synthetase; Validated; Region: pyrG; PRK05380 931276001820 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 931276001821 Catalytic site [active] 931276001822 active site 931276001823 UTP binding site [chemical binding]; other site 931276001824 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 931276001825 active site 931276001826 putative oxyanion hole; other site 931276001827 catalytic triad [active] 931276001828 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 931276001829 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 931276001830 transcription termination factor Rho; Provisional; Region: PRK12608 931276001831 RNA binding site [nucleotide binding]; other site 931276001832 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 931276001833 multimer interface [polypeptide binding]; other site 931276001834 Walker A motif; other site 931276001835 ATP binding site [chemical binding]; other site 931276001836 Walker B motif; other site 931276001837 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 931276001838 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 931276001839 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276001840 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 931276001841 thymidine kinase; Provisional; Region: PRK04296 931276001842 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931276001843 ATP binding site [chemical binding]; other site 931276001844 Walker A motif; other site 931276001845 Walker B motif; other site 931276001846 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 931276001847 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 931276001848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276001849 S-adenosylmethionine binding site [chemical binding]; other site 931276001850 peptide chain release factor 1; Validated; Region: prfA; PRK00591 931276001851 This domain is found in peptide chain release factors; Region: PCRF; smart00937 931276001852 RF-1 domain; Region: RF-1; pfam00472 931276001853 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 931276001854 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 931276001855 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 931276001856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276001857 active site 931276001858 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 931276001859 active site 931276001860 Zn binding site [ion binding]; other site 931276001861 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 931276001862 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 931276001863 active site 931276001864 homodimer interface [polypeptide binding]; other site 931276001865 putative acyltransferase; Provisional; Region: PRK05790 931276001866 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 931276001867 dimer interface [polypeptide binding]; other site 931276001868 active site 931276001869 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 931276001870 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 931276001871 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 931276001872 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 931276001873 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 931276001874 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 931276001875 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 931276001876 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 931276001877 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 931276001878 beta subunit interaction interface [polypeptide binding]; other site 931276001879 Walker A motif; other site 931276001880 ATP binding site [chemical binding]; other site 931276001881 Walker B motif; other site 931276001882 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 931276001883 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 931276001884 core domain interface [polypeptide binding]; other site 931276001885 delta subunit interface [polypeptide binding]; other site 931276001886 epsilon subunit interface [polypeptide binding]; other site 931276001887 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 931276001888 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 931276001889 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 931276001890 alpha subunit interaction interface [polypeptide binding]; other site 931276001891 Walker A motif; other site 931276001892 ATP binding site [chemical binding]; other site 931276001893 Walker B motif; other site 931276001894 inhibitor binding site; inhibition site 931276001895 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 931276001896 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 931276001897 alternate F1F0 ATPase, F1 subunit epsilon; Region: alt_F1F0_F1_eps; TIGR03166 931276001898 gamma subunit interface [polypeptide binding]; other site 931276001899 epsilon subunit interface [polypeptide binding]; other site 931276001900 LBP interface [polypeptide binding]; other site 931276001901 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 931276001902 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 931276001903 hinge; other site 931276001904 active site 931276001905 Stage II sporulation protein; Region: SpoIID; pfam08486 931276001906 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 931276001907 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931276001908 Peptidase family M23; Region: Peptidase_M23; pfam01551 931276001909 Stage III sporulation protein D; Region: SpoIIID; pfam12116 931276001910 rod shape-determining protein Mbl; Provisional; Region: PRK13928 931276001911 MreB and similar proteins; Region: MreB_like; cd10225 931276001912 nucleotide binding site [chemical binding]; other site 931276001913 Mg binding site [ion binding]; other site 931276001914 putative protofilament interaction site [polypeptide binding]; other site 931276001915 RodZ interaction site [polypeptide binding]; other site 931276001916 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 931276001917 S-adenosylmethionine synthetase; Validated; Region: PRK05250 931276001918 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 931276001919 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 931276001920 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 931276001921 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 931276001922 AAA domain; Region: AAA_30; pfam13604 931276001923 Family description; Region: UvrD_C_2; pfam13538 931276001924 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 931276001925 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 931276001926 active site 931276001927 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 931276001928 30S subunit binding site; other site 931276001929 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 931276001930 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 931276001931 SEC-C motif; Region: SEC-C; pfam02810 931276001932 peptide chain release factor 2; Provisional; Region: PRK05589 931276001933 PCRF domain; Region: PCRF; pfam03462 931276001934 RF-1 domain; Region: RF-1; pfam00472 931276001935 Uncharacterized conserved protein [Function unknown]; Region: COG1359 931276001936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276001937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276001938 active site 931276001939 phosphorylation site [posttranslational modification] 931276001940 intermolecular recognition site; other site 931276001941 dimerization interface [polypeptide binding]; other site 931276001942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276001943 DNA binding site [nucleotide binding] 931276001944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276001945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276001946 dimerization interface [polypeptide binding]; other site 931276001947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276001948 dimer interface [polypeptide binding]; other site 931276001949 phosphorylation site [posttranslational modification] 931276001950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276001951 ATP binding site [chemical binding]; other site 931276001952 Mg2+ binding site [ion binding]; other site 931276001953 G-X-G motif; other site 931276001954 CAAX protease self-immunity; Region: Abi; pfam02517 931276001955 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 931276001956 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 931276001957 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 931276001958 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 931276001959 RNA binding site [nucleotide binding]; other site 931276001960 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276001961 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276001962 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276001963 EamA-like transporter family; Region: EamA; pfam00892 931276001964 EamA-like transporter family; Region: EamA; pfam00892 931276001965 Predicted membrane protein [Function unknown]; Region: COG2364 931276001966 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 931276001967 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276001968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276001969 nucleotide binding site [chemical binding]; other site 931276001970 Cache domain; Region: Cache_1; pfam02743 931276001971 HAMP domain; Region: HAMP; pfam00672 931276001972 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276001973 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276001974 dimer interface [polypeptide binding]; other site 931276001975 putative CheW interface [polypeptide binding]; other site 931276001976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276001977 dimerization interface [polypeptide binding]; other site 931276001978 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276001979 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276001980 dimer interface [polypeptide binding]; other site 931276001981 putative CheW interface [polypeptide binding]; other site 931276001982 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 931276001983 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 931276001984 DNA binding site [nucleotide binding] 931276001985 active site 931276001986 endonuclease IV; Provisional; Region: PRK01060 931276001987 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 931276001988 AP (apurinic/apyrimidinic) site pocket; other site 931276001989 DNA interaction; other site 931276001990 Metal-binding active site; metal-binding site 931276001991 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931276001992 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931276001993 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931276001994 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 931276001995 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931276001996 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276001997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276001998 active site 931276001999 motif I; other site 931276002000 motif II; other site 931276002001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276002002 Transcriptional regulator [Transcription]; Region: IclR; COG1414 931276002003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276002004 putative DNA binding site [nucleotide binding]; other site 931276002005 putative Zn2+ binding site [ion binding]; other site 931276002006 Bacterial transcriptional regulator; Region: IclR; pfam01614 931276002007 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 931276002008 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 931276002009 NADP binding site [chemical binding]; other site 931276002010 homodimer interface [polypeptide binding]; other site 931276002011 active site 931276002012 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 931276002013 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 931276002014 substrate binding site [chemical binding]; other site 931276002015 ATP binding site [chemical binding]; other site 931276002016 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 931276002017 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 931276002018 active site 931276002019 intersubunit interface [polypeptide binding]; other site 931276002020 catalytic residue [active] 931276002021 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276002022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276002023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276002024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276002025 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 931276002026 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 931276002027 NADP binding site [chemical binding]; other site 931276002028 homodimer interface [polypeptide binding]; other site 931276002029 active site 931276002030 hypothetical protein; Provisional; Region: PRK09273 931276002031 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 931276002032 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 931276002033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276002034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276002035 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931276002036 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931276002037 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276002038 substrate binding site [chemical binding]; other site 931276002039 active site 931276002040 putative catalytic residue [active] 931276002041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 931276002042 active site 931276002043 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931276002044 classical (c) SDRs; Region: SDR_c; cd05233 931276002045 NAD(P) binding site [chemical binding]; other site 931276002046 active site 931276002047 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 931276002048 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 931276002049 SLBB domain; Region: SLBB; pfam10531 931276002050 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276002051 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 931276002052 FMN-binding domain; Region: FMN_bind; cl01081 931276002053 electron transport complex RsxE subunit; Provisional; Region: PRK12405 931276002054 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 931276002055 ferredoxin; Validated; Region: PRK07118 931276002056 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276002057 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276002058 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 931276002059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276002060 putative active site [active] 931276002061 heme pocket [chemical binding]; other site 931276002062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276002063 Walker A motif; other site 931276002064 ATP binding site [chemical binding]; other site 931276002065 Walker B motif; other site 931276002066 arginine finger; other site 931276002067 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276002068 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 931276002069 putative MPT binding site; other site 931276002070 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931276002071 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 931276002072 catalytic loop [active] 931276002073 iron binding site [ion binding]; other site 931276002074 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931276002075 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931276002076 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931276002077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276002078 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 931276002079 Cysteine-rich domain; Region: CCG; pfam02754 931276002080 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931276002081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276002082 S-adenosylmethionine binding site [chemical binding]; other site 931276002083 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 931276002084 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 931276002085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276002086 FeS/SAM binding site; other site 931276002087 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 931276002088 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 931276002089 XdhC Rossmann domain; Region: XdhC_C; pfam13478 931276002090 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 931276002091 Ligand binding site; other site 931276002092 metal-binding site 931276002093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276002094 Zn2+ binding site [ion binding]; other site 931276002095 Mg2+ binding site [ion binding]; other site 931276002096 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931276002097 catalytic core [active] 931276002098 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 931276002099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931276002100 acyl-activating enzyme (AAE) consensus motif; other site 931276002101 active site 931276002102 AMP binding site [chemical binding]; other site 931276002103 CoA binding site [chemical binding]; other site 931276002104 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 931276002105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276002106 FeS/SAM binding site; other site 931276002107 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 931276002108 MOSC domain; Region: MOSC; pfam03473 931276002109 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276002110 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276002111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276002112 dimer interface [polypeptide binding]; other site 931276002113 putative CheW interface [polypeptide binding]; other site 931276002114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276002115 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276002116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276002117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276002118 WHG domain; Region: WHG; pfam13305 931276002119 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276002120 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276002121 Walker A/P-loop; other site 931276002122 ATP binding site [chemical binding]; other site 931276002123 Q-loop/lid; other site 931276002124 ABC transporter signature motif; other site 931276002125 Walker B; other site 931276002126 D-loop; other site 931276002127 H-loop/switch region; other site 931276002128 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276002129 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931276002130 FtsX-like permease family; Region: FtsX; pfam02687 931276002131 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 931276002132 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276002133 FtsX-like permease family; Region: FtsX; pfam02687 931276002134 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276002135 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276002136 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276002137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276002138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276002139 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 931276002140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276002141 ATP binding site [chemical binding]; other site 931276002142 Q-loop/lid; other site 931276002143 ABC transporter signature motif; other site 931276002144 Walker B; other site 931276002145 D-loop; other site 931276002146 H-loop/switch region; other site 931276002147 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 931276002148 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 931276002149 Hemerythrin; Region: Hemerythrin; cd12107 931276002150 Fe binding site [ion binding]; other site 931276002151 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 931276002152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276002153 dimer interface [polypeptide binding]; other site 931276002154 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276002155 putative CheW interface [polypeptide binding]; other site 931276002156 transcriptional antiterminator BglG; Provisional; Region: PRK09772 931276002157 CAT RNA binding domain; Region: CAT_RBD; smart01061 931276002158 PRD domain; Region: PRD; pfam00874 931276002159 PRD domain; Region: PRD; pfam00874 931276002160 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 931276002161 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276002162 active site turn [active] 931276002163 phosphorylation site [posttranslational modification] 931276002164 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276002165 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 931276002166 HPr interaction site; other site 931276002167 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276002168 active site 931276002169 phosphorylation site [posttranslational modification] 931276002170 Predicted membrane protein [Function unknown]; Region: COG3601 931276002171 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 931276002172 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 931276002173 Rubredoxin; Region: Rubredoxin; pfam00301 931276002174 iron binding site [ion binding]; other site 931276002175 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 931276002176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276002177 Coenzyme A binding pocket [chemical binding]; other site 931276002178 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 931276002179 Glycoprotease family; Region: Peptidase_M22; pfam00814 931276002180 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 931276002181 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 931276002182 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 931276002183 intersubunit interface [polypeptide binding]; other site 931276002184 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 931276002185 ethanolamine permease; Region: 2A0305; TIGR00908 931276002186 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 931276002187 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 931276002188 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 931276002189 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 931276002190 homotrimer interaction site [polypeptide binding]; other site 931276002191 putative active site [active] 931276002192 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 931276002193 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 931276002194 FMN binding site [chemical binding]; other site 931276002195 substrate binding site [chemical binding]; other site 931276002196 putative catalytic residue [active] 931276002197 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 931276002198 putative active site [active] 931276002199 nucleotide binding site [chemical binding]; other site 931276002200 nudix motif; other site 931276002201 putative metal binding site [ion binding]; other site 931276002202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 931276002203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276002204 Coenzyme A binding pocket [chemical binding]; other site 931276002205 Outer membrane efflux protein; Region: OEP; pfam02321 931276002206 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276002207 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276002208 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276002209 ABC transporter; Region: ABC_tran; pfam00005 931276002210 Q-loop/lid; other site 931276002211 ABC transporter signature motif; other site 931276002212 Walker B; other site 931276002213 D-loop; other site 931276002214 H-loop/switch region; other site 931276002215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276002216 FtsX-like permease family; Region: FtsX; pfam02687 931276002217 electron transport complex protein RnfC; Provisional; Region: PRK05035 931276002218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276002219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276002220 active site 931276002221 phosphorylation site [posttranslational modification] 931276002222 intermolecular recognition site; other site 931276002223 dimerization interface [polypeptide binding]; other site 931276002224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276002225 DNA binding site [nucleotide binding] 931276002226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276002227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276002228 dimerization interface [polypeptide binding]; other site 931276002229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276002230 dimer interface [polypeptide binding]; other site 931276002231 phosphorylation site [posttranslational modification] 931276002232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276002233 ATP binding site [chemical binding]; other site 931276002234 Mg2+ binding site [ion binding]; other site 931276002235 G-X-G motif; other site 931276002236 Domain of unknown function (DUF955); Region: DUF955; pfam06114 931276002237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931276002238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276002239 non-specific DNA binding site [nucleotide binding]; other site 931276002240 salt bridge; other site 931276002241 sequence-specific DNA binding site [nucleotide binding]; other site 931276002242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276002243 non-specific DNA binding site [nucleotide binding]; other site 931276002244 salt bridge; other site 931276002245 sequence-specific DNA binding site [nucleotide binding]; other site 931276002246 Protein of unknown function (DUF2009); Region: DUF2009; pfam09418 931276002247 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 931276002248 Phage-related protein [Function unknown]; Region: COG4722 931276002249 Phage tail protein; Region: Sipho_tail; cl17486 931276002250 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 931276002251 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276002252 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276002253 Domain of unknown function DUF11; Region: DUF11; cl17728 931276002254 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 931276002255 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 931276002256 Phage XkdN-like protein; Region: XkdN; pfam08890 931276002257 Phage-related protein [Function unknown]; Region: COG5412 931276002258 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 931276002259 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 931276002260 Baseplate J-like protein; Region: Baseplate_J; pfam04865 931276002261 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 931276002262 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 931276002263 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 931276002264 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 931276002265 Phage XkdN-like protein; Region: XkdN; pfam08890 931276002266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 931276002267 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 931276002268 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 931276002269 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 931276002270 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 931276002271 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 931276002272 Haemolysin XhlA; Region: XhlA; pfam10779 931276002273 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 931276002274 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931276002275 active site 931276002276 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276002277 ornithine carbamoyltransferase; Provisional; Region: PRK00779 931276002278 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 931276002279 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 931276002280 acetylornithine aminotransferase; Provisional; Region: PRK02627 931276002281 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931276002282 inhibitor-cofactor binding pocket; inhibition site 931276002283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276002284 catalytic residue [active] 931276002285 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 931276002286 feedback inhibition sensing region; other site 931276002287 homohexameric interface [polypeptide binding]; other site 931276002288 carbamate kinase; Reviewed; Region: PRK12686 931276002289 nucleotide binding site [chemical binding]; other site 931276002290 N-acetyl-L-glutamate binding site [chemical binding]; other site 931276002291 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 931276002292 heterotetramer interface [polypeptide binding]; other site 931276002293 active site pocket [active] 931276002294 cleavage site 931276002295 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 931276002296 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 931276002297 argininosuccinate lyase; Provisional; Region: PRK00855 931276002298 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 931276002299 active sites [active] 931276002300 tetramer interface [polypeptide binding]; other site 931276002301 argininosuccinate synthase; Provisional; Region: PRK13820 931276002302 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 931276002303 ANP binding site [chemical binding]; other site 931276002304 Substrate Binding Site II [chemical binding]; other site 931276002305 Substrate Binding Site I [chemical binding]; other site 931276002306 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 931276002307 Predicted membrane protein [Function unknown]; Region: COG2323 931276002308 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 931276002309 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 931276002310 active site 931276002311 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 931276002312 amphipathic channel; other site 931276002313 Asn-Pro-Ala signature motifs; other site 931276002314 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 931276002315 glycerol kinase; Provisional; Region: glpK; PRK00047 931276002316 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 931276002317 N- and C-terminal domain interface [polypeptide binding]; other site 931276002318 active site 931276002319 MgATP binding site [chemical binding]; other site 931276002320 catalytic site [active] 931276002321 metal binding site [ion binding]; metal-binding site 931276002322 glycerol binding site [chemical binding]; other site 931276002323 homotetramer interface [polypeptide binding]; other site 931276002324 homodimer interface [polypeptide binding]; other site 931276002325 FBP binding site [chemical binding]; other site 931276002326 protein IIAGlc interface [polypeptide binding]; other site 931276002327 Predicted dehydrogenase [General function prediction only]; Region: COG0579 931276002328 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931276002329 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931276002330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931276002331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276002332 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 931276002333 Helix-turn-helix domain; Region: HTH_18; pfam12833 931276002334 YtxH-like protein; Region: YtxH; pfam12732 931276002335 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 931276002336 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 931276002337 Melibiase; Region: Melibiase; pfam02065 931276002338 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276002339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276002340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276002341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276002342 FtsX-like permease family; Region: FtsX; pfam02687 931276002343 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931276002344 FtsX-like permease family; Region: FtsX; pfam02687 931276002345 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276002346 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276002347 Walker A/P-loop; other site 931276002348 ATP binding site [chemical binding]; other site 931276002349 Q-loop/lid; other site 931276002350 ABC transporter signature motif; other site 931276002351 Walker B; other site 931276002352 D-loop; other site 931276002353 H-loop/switch region; other site 931276002354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276002355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276002356 dimer interface [polypeptide binding]; other site 931276002357 phosphorylation site [posttranslational modification] 931276002358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276002359 ATP binding site [chemical binding]; other site 931276002360 Mg2+ binding site [ion binding]; other site 931276002361 G-X-G motif; other site 931276002362 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276002363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276002364 active site 931276002365 phosphorylation site [posttranslational modification] 931276002366 intermolecular recognition site; other site 931276002367 dimerization interface [polypeptide binding]; other site 931276002368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276002369 DNA binding site [nucleotide binding] 931276002370 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 931276002371 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 931276002372 active site 931276002373 substrate binding site [chemical binding]; other site 931276002374 trimer interface [polypeptide binding]; other site 931276002375 CoA binding site [chemical binding]; other site 931276002376 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 931276002377 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 931276002378 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 931276002379 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 931276002380 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 931276002381 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 931276002382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276002383 active site 931276002384 phosphorylation site [posttranslational modification] 931276002385 intermolecular recognition site; other site 931276002386 dimerization interface [polypeptide binding]; other site 931276002387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276002388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276002389 dimerization interface [polypeptide binding]; other site 931276002390 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931276002391 Histidine kinase; Region: His_kinase; pfam06580 931276002392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276002393 ATP binding site [chemical binding]; other site 931276002394 Mg2+ binding site [ion binding]; other site 931276002395 G-X-G motif; other site 931276002396 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276002397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276002398 dimer interface [polypeptide binding]; other site 931276002399 conserved gate region; other site 931276002400 putative PBP binding loops; other site 931276002401 ABC-ATPase subunit interface; other site 931276002402 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276002403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276002404 dimer interface [polypeptide binding]; other site 931276002405 conserved gate region; other site 931276002406 putative PBP binding loops; other site 931276002407 ABC-ATPase subunit interface; other site 931276002408 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 931276002409 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 931276002410 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 931276002411 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 931276002412 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 931276002413 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276002414 DNA binding site [nucleotide binding] 931276002415 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 931276002416 putative ligand binding site [chemical binding]; other site 931276002417 putative dimerization interface [polypeptide binding]; other site 931276002418 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276002419 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276002420 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276002421 dimer interface [polypeptide binding]; other site 931276002422 putative CheW interface [polypeptide binding]; other site 931276002423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276002424 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 931276002425 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 931276002426 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 931276002427 putative L-serine binding site [chemical binding]; other site 931276002428 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 931276002429 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 931276002430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276002431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276002432 active site 931276002433 phosphorylation site [posttranslational modification] 931276002434 intermolecular recognition site; other site 931276002435 dimerization interface [polypeptide binding]; other site 931276002436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276002437 DNA binding site [nucleotide binding] 931276002438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276002439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276002440 dimerization interface [polypeptide binding]; other site 931276002441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276002442 dimer interface [polypeptide binding]; other site 931276002443 phosphorylation site [posttranslational modification] 931276002444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276002445 ATP binding site [chemical binding]; other site 931276002446 Mg2+ binding site [ion binding]; other site 931276002447 G-X-G motif; other site 931276002448 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 931276002449 ApbE family; Region: ApbE; pfam02424 931276002450 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276002451 FMN-binding domain; Region: FMN_bind; cl01081 931276002452 FMN-binding domain; Region: FMN_bind; cl01081 931276002453 FMN-binding domain; Region: FMN_bind; cl01081 931276002454 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 931276002455 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276002456 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276002457 FMN-binding domain; Region: FMN_bind; cl01081 931276002458 FMN-binding domain; Region: FMN_bind; cl01081 931276002459 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 931276002460 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 931276002461 dimer interface [polypeptide binding]; other site 931276002462 substrate binding site [chemical binding]; other site 931276002463 ATP binding site [chemical binding]; other site 931276002464 ThiC family; Region: ThiC; pfam01964 931276002465 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 931276002466 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 931276002467 substrate binding site [chemical binding]; other site 931276002468 multimerization interface [polypeptide binding]; other site 931276002469 ATP binding site [chemical binding]; other site 931276002470 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 931276002471 thiamine phosphate binding site [chemical binding]; other site 931276002472 active site 931276002473 pyrophosphate binding site [ion binding]; other site 931276002474 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 931276002475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276002476 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276002477 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 931276002478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276002479 S-adenosylmethionine binding site [chemical binding]; other site 931276002480 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 931276002481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276002482 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276002483 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 931276002484 iron binding site [ion binding]; other site 931276002485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931276002486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276002487 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276002488 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276002489 Metal-binding active site; metal-binding site 931276002490 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 931276002491 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 931276002492 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 931276002493 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 931276002494 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276002495 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 931276002496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276002497 ATP binding site [chemical binding]; other site 931276002498 putative Mg++ binding site [ion binding]; other site 931276002499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276002500 nucleotide binding region [chemical binding]; other site 931276002501 ATP-binding site [chemical binding]; other site 931276002502 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 931276002503 HRDC domain; Region: HRDC; pfam00570 931276002504 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 931276002505 plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517 931276002506 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276002507 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 931276002508 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931276002509 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931276002510 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276002511 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276002512 Zn2+ binding site [ion binding]; other site 931276002513 Mg2+ binding site [ion binding]; other site 931276002514 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 931276002515 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276002516 active site 931276002517 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276002518 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276002519 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 931276002520 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 931276002521 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 931276002522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276002523 catalytic residue [active] 931276002524 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 931276002525 Right handed beta helix region; Region: Beta_helix; pfam13229 931276002526 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 931276002527 Interdomain contacts; other site 931276002528 Cytokine receptor motif; other site 931276002529 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931276002530 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276002531 ligand binding site [chemical binding]; other site 931276002532 flexible hinge region; other site 931276002533 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 931276002534 hybrid cluster protein; Provisional; Region: PRK05290 931276002535 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276002536 ACS interaction site; other site 931276002537 CODH interaction site; other site 931276002538 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 931276002539 hybrid metal cluster; other site 931276002540 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 931276002541 lysine transporter; Provisional; Region: PRK10836 931276002542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276002543 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276002544 substrate binding pocket [chemical binding]; other site 931276002545 membrane-bound complex binding site; other site 931276002546 hinge residues; other site 931276002547 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931276002548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276002549 dimer interface [polypeptide binding]; other site 931276002550 conserved gate region; other site 931276002551 putative PBP binding loops; other site 931276002552 ABC-ATPase subunit interface; other site 931276002553 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276002554 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276002555 Walker A/P-loop; other site 931276002556 ATP binding site [chemical binding]; other site 931276002557 Q-loop/lid; other site 931276002558 ABC transporter signature motif; other site 931276002559 Walker B; other site 931276002560 D-loop; other site 931276002561 H-loop/switch region; other site 931276002562 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 931276002563 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276002564 putative active site [active] 931276002565 putative metal binding site [ion binding]; other site 931276002566 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931276002567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931276002568 Walker A/P-loop; other site 931276002569 ATP binding site [chemical binding]; other site 931276002570 Q-loop/lid; other site 931276002571 ABC transporter signature motif; other site 931276002572 Walker B; other site 931276002573 D-loop; other site 931276002574 H-loop/switch region; other site 931276002575 Predicted transcriptional regulators [Transcription]; Region: COG1725 931276002576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276002577 DNA-binding site [nucleotide binding]; DNA binding site 931276002578 Sensory domain found in PocR; Region: PocR; pfam10114 931276002579 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931276002580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276002581 dimer interface [polypeptide binding]; other site 931276002582 putative CheW interface [polypeptide binding]; other site 931276002583 Quinolinate synthetase A protein; Region: NadA; pfam02445 931276002584 L-aspartate oxidase; Provisional; Region: PRK06175 931276002585 FAD binding domain; Region: FAD_binding_2; pfam00890 931276002586 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 931276002587 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 931276002588 dimerization interface [polypeptide binding]; other site 931276002589 active site 931276002590 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931276002591 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931276002592 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 931276002593 Ligand Binding Site [chemical binding]; other site 931276002594 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 931276002595 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 931276002596 active site 931276002597 HIGH motif; other site 931276002598 dimer interface [polypeptide binding]; other site 931276002599 KMSKS motif; other site 931276002600 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 931276002601 DNA polymerase I; Provisional; Region: PRK05755 931276002602 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 931276002603 active site 931276002604 metal binding site 1 [ion binding]; metal-binding site 931276002605 putative 5' ssDNA interaction site; other site 931276002606 metal binding site 3; metal-binding site 931276002607 metal binding site 2 [ion binding]; metal-binding site 931276002608 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 931276002609 putative DNA binding site [nucleotide binding]; other site 931276002610 putative metal binding site [ion binding]; other site 931276002611 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 931276002612 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 931276002613 active site 931276002614 DNA binding site [nucleotide binding] 931276002615 catalytic site [active] 931276002616 dephospho-CoA kinase; Region: TIGR00152 931276002617 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 931276002618 CoA-binding site [chemical binding]; other site 931276002619 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 931276002620 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 931276002621 N-acetyl-D-glucosamine binding site [chemical binding]; other site 931276002622 catalytic residue [active] 931276002623 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 931276002624 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 931276002625 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 931276002626 acyl-activating enzyme (AAE) consensus motif; other site 931276002627 AMP binding site [chemical binding]; other site 931276002628 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 931276002629 catalytic triad [active] 931276002630 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 931276002631 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 931276002632 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276002633 active site 931276002634 HIGH motif; other site 931276002635 nucleotide binding site [chemical binding]; other site 931276002636 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276002637 KMSKS motif; other site 931276002638 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 931276002639 anticodon binding site; other site 931276002640 tRNA binding surface [nucleotide binding]; other site 931276002641 Predicted membrane protein [Function unknown]; Region: COG1511 931276002642 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931276002643 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 931276002644 Predicted membrane protein [Function unknown]; Region: COG1511 931276002645 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931276002646 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 931276002647 TspO/MBR family; Region: TspO_MBR; pfam03073 931276002648 AAA domain; Region: AAA_32; pfam13654 931276002649 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 931276002650 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 931276002651 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 931276002652 anti sigma factor interaction site; other site 931276002653 regulatory phosphorylation site [posttranslational modification]; other site 931276002654 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 931276002655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276002656 ATP binding site [chemical binding]; other site 931276002657 Mg2+ binding site [ion binding]; other site 931276002658 G-X-G motif; other site 931276002659 sporulation sigma factor SigF; Validated; Region: PRK05572 931276002660 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 931276002661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276002662 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 931276002663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276002664 DNA binding residues [nucleotide binding] 931276002665 SpoVA protein; Region: SpoVA; cl04298 931276002666 stage V sporulation protein AD; Validated; Region: PRK08304 931276002667 stage V sporulation protein AD; Provisional; Region: PRK12404 931276002668 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 931276002669 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 931276002670 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 931276002671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276002672 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 931276002673 Competence protein; Region: Competence; pfam03772 931276002674 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 931276002675 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 931276002676 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 931276002677 germination protease; Provisional; Region: PRK12362 931276002678 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 931276002679 stage II sporulation protein P; Region: spore_II_P; TIGR02867 931276002680 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 931276002681 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 931276002682 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276002683 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931276002684 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 931276002685 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 931276002686 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 931276002687 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 931276002688 Ligand Binding Site [chemical binding]; other site 931276002689 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 931276002690 GAF domain; Region: GAF_3; pfam13492 931276002691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276002692 phosphorylation site [posttranslational modification] 931276002693 dimer interface [polypeptide binding]; other site 931276002694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276002695 ATP binding site [chemical binding]; other site 931276002696 Mg2+ binding site [ion binding]; other site 931276002697 G-X-G motif; other site 931276002698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276002699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276002700 active site 931276002701 phosphorylation site [posttranslational modification] 931276002702 intermolecular recognition site; other site 931276002703 dimerization interface [polypeptide binding]; other site 931276002704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276002705 DNA binding site [nucleotide binding] 931276002706 GTP-binding protein LepA; Provisional; Region: PRK05433 931276002707 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 931276002708 G1 box; other site 931276002709 putative GEF interaction site [polypeptide binding]; other site 931276002710 GTP/Mg2+ binding site [chemical binding]; other site 931276002711 Switch I region; other site 931276002712 G2 box; other site 931276002713 G3 box; other site 931276002714 Switch II region; other site 931276002715 G4 box; other site 931276002716 G5 box; other site 931276002717 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 931276002718 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 931276002719 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 931276002720 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 931276002721 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276002722 FeS/SAM binding site; other site 931276002723 HemN C-terminal domain; Region: HemN_C; pfam06969 931276002724 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 931276002725 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 931276002726 GrpE; Region: GrpE; pfam01025 931276002727 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 931276002728 dimer interface [polypeptide binding]; other site 931276002729 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 931276002730 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 931276002731 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 931276002732 nucleotide binding site [chemical binding]; other site 931276002733 NEF interaction site [polypeptide binding]; other site 931276002734 SBD interface [polypeptide binding]; other site 931276002735 chaperone protein DnaJ; Provisional; Region: PRK14297 931276002736 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 931276002737 HSP70 interaction site [polypeptide binding]; other site 931276002738 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 931276002739 substrate binding site [polypeptide binding]; other site 931276002740 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 931276002741 Zn binding sites [ion binding]; other site 931276002742 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 931276002743 dimer interface [polypeptide binding]; other site 931276002744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276002745 S-adenosylmethionine binding site [chemical binding]; other site 931276002746 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 931276002747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276002748 S-adenosylmethionine binding site [chemical binding]; other site 931276002749 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 931276002750 RNA methyltransferase, RsmE family; Region: TIGR00046 931276002751 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 931276002752 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 931276002753 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 931276002754 nucleotide binding site/active site [active] 931276002755 HIT family signature motif; other site 931276002756 catalytic residue [active] 931276002757 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 931276002758 Yqey-like protein; Region: YqeY; pfam09424 931276002759 YabP family; Region: YabP; cl06766 931276002760 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 931276002761 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 931276002762 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 931276002763 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 931276002764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276002765 Zn2+ binding site [ion binding]; other site 931276002766 Mg2+ binding site [ion binding]; other site 931276002767 metal-binding heat shock protein; Provisional; Region: PRK00016 931276002768 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 931276002769 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 931276002770 active site 931276002771 GTPase Era; Reviewed; Region: era; PRK00089 931276002772 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 931276002773 G1 box; other site 931276002774 GTP/Mg2+ binding site [chemical binding]; other site 931276002775 Switch I region; other site 931276002776 G2 box; other site 931276002777 Switch II region; other site 931276002778 G3 box; other site 931276002779 G4 box; other site 931276002780 G5 box; other site 931276002781 KH domain; Region: KH_2; pfam07650 931276002782 Recombination protein O N terminal; Region: RecO_N; pfam11967 931276002783 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 931276002784 Recombination protein O C terminal; Region: RecO_C; pfam02565 931276002785 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 931276002786 HTH domain; Region: HTH_11; pfam08279 931276002787 FOG: CBS domain [General function prediction only]; Region: COG0517 931276002788 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 931276002789 pyruvate phosphate dikinase; Provisional; Region: PRK09279 931276002790 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 931276002791 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 931276002792 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 931276002793 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 931276002794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 931276002795 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 931276002796 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276002797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276002798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276002799 WHG domain; Region: WHG; pfam13305 931276002800 drug efflux system protein MdtG; Provisional; Region: PRK09874 931276002801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276002802 putative substrate translocation pore; other site 931276002803 Isochorismatase family; Region: Isochorismatase; pfam00857 931276002804 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 931276002805 catalytic triad [active] 931276002806 conserved cis-peptide bond; other site 931276002807 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931276002808 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 931276002809 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 931276002810 dimerization interface [polypeptide binding]; other site 931276002811 Histidine kinase; Region: His_kinase; pfam06580 931276002812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276002813 ATP binding site [chemical binding]; other site 931276002814 Mg2+ binding site [ion binding]; other site 931276002815 G-X-G motif; other site 931276002816 Response regulator receiver domain; Region: Response_reg; pfam00072 931276002817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276002818 active site 931276002819 phosphorylation site [posttranslational modification] 931276002820 intermolecular recognition site; other site 931276002821 dimerization interface [polypeptide binding]; other site 931276002822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276002823 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276002824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276002825 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276002826 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276002827 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 931276002828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276002829 dimer interface [polypeptide binding]; other site 931276002830 conserved gate region; other site 931276002831 putative PBP binding loops; other site 931276002832 ABC-ATPase subunit interface; other site 931276002833 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276002834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276002835 dimer interface [polypeptide binding]; other site 931276002836 conserved gate region; other site 931276002837 putative PBP binding loops; other site 931276002838 ABC-ATPase subunit interface; other site 931276002839 alpha-glucosidase; Provisional; Region: PRK10426 931276002840 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 931276002841 putative active site [active] 931276002842 putative catalytic site [active] 931276002843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 931276002844 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 931276002845 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276002846 transcriptional antiterminator BglG; Provisional; Region: PRK09772 931276002847 CAT RNA binding domain; Region: CAT_RBD; pfam03123 931276002848 PRD domain; Region: PRD; pfam00874 931276002849 PRD domain; Region: PRD; pfam00874 931276002850 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 931276002851 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276002852 active site turn [active] 931276002853 phosphorylation site [posttranslational modification] 931276002854 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276002855 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 931276002856 HPr interaction site; other site 931276002857 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276002858 active site 931276002859 phosphorylation site [posttranslational modification] 931276002860 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276002861 beta-galactosidase; Region: BGL; TIGR03356 931276002862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 931276002863 Sterol carrier protein domain; Region: SCP2_2; pfam13530 931276002864 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 931276002865 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 931276002866 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 931276002867 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276002868 Zn2+ binding site [ion binding]; other site 931276002869 Mg2+ binding site [ion binding]; other site 931276002870 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 931276002871 DNA primase; Validated; Region: dnaG; PRK05667 931276002872 CHC2 zinc finger; Region: zf-CHC2; pfam01807 931276002873 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 931276002874 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 931276002875 active site 931276002876 metal binding site [ion binding]; metal-binding site 931276002877 interdomain interaction site; other site 931276002878 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 931276002879 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 931276002880 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 931276002881 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 931276002882 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 931276002883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276002884 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 931276002885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276002886 DNA binding residues [nucleotide binding] 931276002887 Family of unknown function (DUF633); Region: DUF633; pfam04816 931276002888 Uncharacterized conserved protein [Function unknown]; Region: COG0327 931276002889 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 931276002890 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276002891 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276002892 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276002893 putative active site [active] 931276002894 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276002895 methionine cluster; other site 931276002896 active site 931276002897 phosphorylation site [posttranslational modification] 931276002898 metal binding site [ion binding]; metal-binding site 931276002899 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276002900 beta-galactosidase; Region: BGL; TIGR03356 931276002901 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276002902 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276002903 short chain dehydrogenase; Provisional; Region: PRK06914 931276002904 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 931276002905 NADP binding site [chemical binding]; other site 931276002906 active site 931276002907 steroid binding site; other site 931276002908 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 931276002909 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931276002910 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931276002911 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 931276002912 FAD binding domain; Region: FAD_binding_4; pfam01565 931276002913 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 931276002914 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 931276002915 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931276002916 catalytic loop [active] 931276002917 iron binding site [ion binding]; other site 931276002918 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931276002919 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 931276002920 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 931276002921 putative FMN binding site [chemical binding]; other site 931276002922 NADPH bind site [chemical binding]; other site 931276002923 hybrid cluster protein; Provisional; Region: PRK05290 931276002924 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276002925 ACS interaction site; other site 931276002926 CODH interaction site; other site 931276002927 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 931276002928 hybrid metal cluster; other site 931276002929 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 931276002930 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 931276002931 active site 931276002932 catalytic triad [active] 931276002933 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 931276002934 active site 931276002935 catalytic triad [active] 931276002936 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 931276002937 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 931276002938 Walker A/P-loop; other site 931276002939 ATP binding site [chemical binding]; other site 931276002940 Q-loop/lid; other site 931276002941 ABC transporter signature motif; other site 931276002942 Walker B; other site 931276002943 D-loop; other site 931276002944 H-loop/switch region; other site 931276002945 TOBE domain; Region: TOBE; pfam03459 931276002946 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276002947 4-alpha-glucanotransferase; Provisional; Region: PRK14508 931276002948 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 931276002949 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 931276002950 homodimer interface [polypeptide binding]; other site 931276002951 active site pocket [active] 931276002952 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 931276002953 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 931276002954 putative ligand binding site [chemical binding]; other site 931276002955 putative NAD binding site [chemical binding]; other site 931276002956 catalytic site [active] 931276002957 DNA topoisomerase III; Provisional; Region: PRK07726 931276002958 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 931276002959 active site 931276002960 putative interdomain interaction site [polypeptide binding]; other site 931276002961 putative metal-binding site [ion binding]; other site 931276002962 putative nucleotide binding site [chemical binding]; other site 931276002963 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 931276002964 domain I; other site 931276002965 DNA binding groove [nucleotide binding] 931276002966 phosphate binding site [ion binding]; other site 931276002967 domain II; other site 931276002968 domain III; other site 931276002969 nucleotide binding site [chemical binding]; other site 931276002970 catalytic site [active] 931276002971 domain IV; other site 931276002972 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 931276002973 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 931276002974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276002975 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 931276002976 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 931276002977 iron-sulfur cluster [ion binding]; other site 931276002978 [2Fe-2S] cluster binding site [ion binding]; other site 931276002979 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 931276002980 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931276002981 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 931276002982 Na binding site [ion binding]; other site 931276002983 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 931276002984 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 931276002985 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 931276002986 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 931276002987 catalytic residues [active] 931276002988 catalytic nucleophile [active] 931276002989 Recombinase; Region: Recombinase; pfam07508 931276002990 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 931276002991 Domain of unknown function (DUF955); Region: DUF955; cl01076 931276002992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276002993 sequence-specific DNA binding site [nucleotide binding]; other site 931276002994 salt bridge; other site 931276002995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276002996 non-specific DNA binding site [nucleotide binding]; other site 931276002997 salt bridge; other site 931276002998 sequence-specific DNA binding site [nucleotide binding]; other site 931276002999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276003000 salt bridge; other site 931276003001 non-specific DNA binding site [nucleotide binding]; other site 931276003002 sequence-specific DNA binding site [nucleotide binding]; other site 931276003003 Helix-turn-helix domain; Region: HTH_36; pfam13730 931276003004 Restriction endonuclease; Region: Mrr_cat; pfam04471 931276003005 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 931276003006 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276003007 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276003008 active site 931276003009 DNA binding site [nucleotide binding] 931276003010 Int/Topo IB signature motif; other site 931276003011 M6 family metalloprotease domain; Region: M6dom_TIGR03296 931276003012 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 931276003013 Phage portal protein; Region: Phage_portal; pfam04860 931276003014 Phage-related protein [Function unknown]; Region: COG4695; cl01923 931276003015 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 931276003016 oligomer interface [polypeptide binding]; other site 931276003017 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 931276003018 active site residues [active] 931276003019 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 931276003020 Phage capsid family; Region: Phage_capsid; pfam05065 931276003021 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 931276003022 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 931276003023 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 931276003024 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 931276003025 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 931276003026 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 931276003027 Phage-related protein [Function unknown]; Region: COG4722 931276003028 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 931276003029 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 931276003030 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276003031 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276003032 Domain of unknown function DUF11; Region: DUF11; pfam01345 931276003033 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 931276003034 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931276003035 active site 931276003036 metal binding site [ion binding]; metal-binding site 931276003037 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 931276003038 dinuclear metal binding motif [ion binding]; other site 931276003039 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 931276003040 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 931276003041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 931276003042 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 931276003043 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931276003044 Walker A/P-loop; other site 931276003045 ATP binding site [chemical binding]; other site 931276003046 Q-loop/lid; other site 931276003047 ABC transporter signature motif; other site 931276003048 Walker B; other site 931276003049 D-loop; other site 931276003050 H-loop/switch region; other site 931276003051 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931276003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276003053 dimer interface [polypeptide binding]; other site 931276003054 conserved gate region; other site 931276003055 putative PBP binding loops; other site 931276003056 ABC-ATPase subunit interface; other site 931276003057 Uncharacterized conserved protein [Function unknown]; Region: COG1284 931276003058 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 931276003059 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 931276003060 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 931276003061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 931276003062 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 931276003063 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 931276003064 catalytic triad [active] 931276003065 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 931276003066 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276003067 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 931276003068 Cell division protein ZapA; Region: ZapA; pfam05164 931276003069 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 931276003070 Peptidase family U32; Region: Peptidase_U32; pfam01136 931276003071 Collagenase; Region: DUF3656; pfam12392 931276003072 Peptidase family U32; Region: Peptidase_U32; cl03113 931276003073 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 931276003074 MutS domain III; Region: MutS_III; pfam05192 931276003075 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 931276003076 Walker A/P-loop; other site 931276003077 ATP binding site [chemical binding]; other site 931276003078 Q-loop/lid; other site 931276003079 ABC transporter signature motif; other site 931276003080 Walker B; other site 931276003081 D-loop; other site 931276003082 H-loop/switch region; other site 931276003083 Smr domain; Region: Smr; pfam01713 931276003084 Uncharacterized conserved protein [Function unknown]; Region: COG1683 931276003085 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276003086 beta-galactosidase; Region: BGL; TIGR03356 931276003087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276003088 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 931276003089 putative substrate translocation pore; other site 931276003090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276003091 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 931276003092 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 931276003093 putative active site [active] 931276003094 metal binding site [ion binding]; metal-binding site 931276003095 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931276003096 MarR family; Region: MarR; pfam01047 931276003097 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 931276003098 catalytic residues [active] 931276003099 dimer interface [polypeptide binding]; other site 931276003100 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 931276003101 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931276003102 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931276003103 catalytic residues [active] 931276003104 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 931276003105 catalytic residues [active] 931276003106 dimer interface [polypeptide binding]; other site 931276003107 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276003108 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 931276003109 DNA binding site [nucleotide binding] 931276003110 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276003111 active site 931276003112 metal binding site [ion binding]; metal-binding site 931276003113 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 931276003114 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 931276003115 AAA domain; Region: AAA_23; pfam13476 931276003116 Walker A/P-loop; other site 931276003117 ATP binding site [chemical binding]; other site 931276003118 Q-loop/lid; other site 931276003119 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 931276003120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276003121 ABC transporter signature motif; other site 931276003122 Walker B; other site 931276003123 D-loop; other site 931276003124 H-loop/switch region; other site 931276003125 hybrid cluster protein; Provisional; Region: PRK05290 931276003126 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276003127 ACS interaction site; other site 931276003128 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276003129 ACS interaction site; other site 931276003130 CODH interaction site; other site 931276003131 metal cluster binding site [ion binding]; other site 931276003132 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931276003133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276003134 active site 931276003135 phosphorylation site [posttranslational modification] 931276003136 intermolecular recognition site; other site 931276003137 dimerization interface [polypeptide binding]; other site 931276003138 LytTr DNA-binding domain; Region: LytTR; smart00850 931276003139 hypothetical protein; Provisional; Region: PRK13665 931276003140 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 931276003141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276003142 ATP binding site [chemical binding]; other site 931276003143 Mg2+ binding site [ion binding]; other site 931276003144 G-X-G motif; other site 931276003145 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 931276003146 active site 931276003147 substrate binding site [chemical binding]; other site 931276003148 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 931276003149 metal binding site [ion binding]; metal-binding site 931276003150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276003151 binding surface 931276003152 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276003153 TPR motif; other site 931276003154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276003155 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 931276003156 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 931276003157 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 931276003158 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 931276003159 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276003160 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 931276003161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276003162 O-Antigen ligase; Region: Wzy_C; pfam04932 931276003163 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 931276003164 Transposase, Mutator family; Region: Transposase_mut; pfam00872 931276003165 MULE transposase domain; Region: MULE; pfam10551 931276003166 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 931276003167 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 931276003168 NodB motif; other site 931276003169 active site 931276003170 catalytic site [active] 931276003171 Cd binding site [ion binding]; other site 931276003172 GTP-binding protein YchF; Reviewed; Region: PRK09601 931276003173 YchF GTPase; Region: YchF; cd01900 931276003174 G1 box; other site 931276003175 GTP/Mg2+ binding site [chemical binding]; other site 931276003176 Switch I region; other site 931276003177 G2 box; other site 931276003178 Switch II region; other site 931276003179 G3 box; other site 931276003180 G4 box; other site 931276003181 G5 box; other site 931276003182 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 931276003183 TPR repeat; Region: TPR_11; pfam13414 931276003184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276003185 TPR motif; other site 931276003186 binding surface 931276003187 Tetratricopeptide repeat; Region: TPR_16; pfam13432 931276003188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276003189 TPR motif; other site 931276003190 binding surface 931276003191 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 931276003192 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 931276003193 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 931276003194 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 931276003195 phosphofructokinase; Region: PFK_mixed; TIGR02483 931276003196 active site 931276003197 ADP/pyrophosphate binding site [chemical binding]; other site 931276003198 dimerization interface [polypeptide binding]; other site 931276003199 allosteric effector site; other site 931276003200 fructose-1,6-bisphosphate binding site; other site 931276003201 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 931276003202 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 931276003203 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 931276003204 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 931276003205 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 931276003206 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 931276003207 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 931276003208 dihydroorotase; Validated; Region: pyrC; PRK09357 931276003209 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931276003210 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 931276003211 active site 931276003212 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 931276003213 active site 931276003214 dimer interface [polypeptide binding]; other site 931276003215 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 931276003216 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 931276003217 FAD binding pocket [chemical binding]; other site 931276003218 FAD binding motif [chemical binding]; other site 931276003219 phosphate binding motif [ion binding]; other site 931276003220 beta-alpha-beta structure motif; other site 931276003221 NAD binding pocket [chemical binding]; other site 931276003222 Iron coordination center [ion binding]; other site 931276003223 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 931276003224 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 931276003225 heterodimer interface [polypeptide binding]; other site 931276003226 active site 931276003227 FMN binding site [chemical binding]; other site 931276003228 homodimer interface [polypeptide binding]; other site 931276003229 substrate binding site [chemical binding]; other site 931276003230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276003231 active site 931276003232 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 931276003233 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 931276003234 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 931276003235 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 931276003236 Pyruvate formate lyase 1; Region: PFL1; cd01678 931276003237 coenzyme A binding site [chemical binding]; other site 931276003238 active site 931276003239 catalytic residues [active] 931276003240 glycine loop; other site 931276003241 Rubredoxin [Energy production and conversion]; Region: COG1773 931276003242 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 931276003243 iron binding site [ion binding]; other site 931276003244 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 931276003245 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 931276003246 active site 931276003247 catalytic site [active] 931276003248 substrate binding site [chemical binding]; other site 931276003249 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 931276003250 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 931276003251 NAD binding site [chemical binding]; other site 931276003252 dimer interface [polypeptide binding]; other site 931276003253 substrate binding site [chemical binding]; other site 931276003254 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276003255 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 931276003256 Biotin operon repressor [Transcription]; Region: BirA; COG1654 931276003257 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 931276003258 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 931276003259 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 931276003260 Peptidase family M50; Region: Peptidase_M50; pfam02163 931276003261 active site 931276003262 putative substrate binding region [chemical binding]; other site 931276003263 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276003264 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276003265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276003266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276003267 dimerization interface [polypeptide binding]; other site 931276003268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276003269 dimer interface [polypeptide binding]; other site 931276003270 phosphorylation site [posttranslational modification] 931276003271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276003272 ATP binding site [chemical binding]; other site 931276003273 Mg2+ binding site [ion binding]; other site 931276003274 G-X-G motif; other site 931276003275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276003277 active site 931276003278 phosphorylation site [posttranslational modification] 931276003279 intermolecular recognition site; other site 931276003280 dimerization interface [polypeptide binding]; other site 931276003281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276003282 DNA binding site [nucleotide binding] 931276003283 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 931276003284 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 931276003285 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276003286 KMSKS motif; other site 931276003287 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 931276003288 tRNA binding surface [nucleotide binding]; other site 931276003289 anticodon binding site; other site 931276003290 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931276003291 Domain of unknown function DUF20; Region: UPF0118; pfam01594 931276003292 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 931276003293 putative FMN binding site [chemical binding]; other site 931276003294 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 931276003295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276003296 motif II; other site 931276003297 RNase_H superfamily; Region: RNase_H_2; pfam13482 931276003298 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 931276003299 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 931276003300 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 931276003301 active site 931276003302 metal-binding site [ion binding] 931276003303 nucleotide-binding site [chemical binding]; other site 931276003304 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 931276003305 Domain of unknown function (DUF378); Region: DUF378; cl00943 931276003306 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 931276003307 AsnC family; Region: AsnC_trans_reg; pfam01037 931276003308 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 931276003309 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 931276003310 trimer interface [polypeptide binding]; other site 931276003311 putative metal binding site [ion binding]; other site 931276003312 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 931276003313 S1 domain; Region: S1_2; pfam13509 931276003314 S1 domain; Region: S1_2; pfam13509 931276003315 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 931276003316 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 931276003317 active site 931276003318 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 931276003319 dimer interface [polypeptide binding]; other site 931276003320 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 931276003321 Ligand Binding Site [chemical binding]; other site 931276003322 Molecular Tunnel; other site 931276003323 Protein of unknown function (DUF327); Region: DUF327; pfam03885 931276003324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 931276003325 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 931276003326 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931276003327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 931276003328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276003329 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276003330 Walker A/P-loop; other site 931276003331 ATP binding site [chemical binding]; other site 931276003332 Q-loop/lid; other site 931276003333 ABC transporter signature motif; other site 931276003334 Walker B; other site 931276003335 D-loop; other site 931276003336 H-loop/switch region; other site 931276003337 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276003338 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276003339 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 931276003340 Walker A/P-loop; other site 931276003341 ATP binding site [chemical binding]; other site 931276003342 Q-loop/lid; other site 931276003343 ABC transporter signature motif; other site 931276003344 Walker B; other site 931276003345 D-loop; other site 931276003346 H-loop/switch region; other site 931276003347 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 931276003348 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 931276003349 homodimer interface [polypeptide binding]; other site 931276003350 substrate-cofactor binding pocket; other site 931276003351 catalytic residue [active] 931276003352 NAD synthetase; Reviewed; Region: nadE; PRK02628 931276003353 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 931276003354 multimer interface [polypeptide binding]; other site 931276003355 active site 931276003356 catalytic triad [active] 931276003357 protein interface 1 [polypeptide binding]; other site 931276003358 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 931276003359 homodimer interface [polypeptide binding]; other site 931276003360 NAD binding pocket [chemical binding]; other site 931276003361 ATP binding pocket [chemical binding]; other site 931276003362 Mg binding site [ion binding]; other site 931276003363 active-site loop [active] 931276003364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276003365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276003366 active site 931276003367 phosphorylation site [posttranslational modification] 931276003368 intermolecular recognition site; other site 931276003369 dimerization interface [polypeptide binding]; other site 931276003370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276003371 DNA binding site [nucleotide binding] 931276003372 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 931276003373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276003374 dimerization interface [polypeptide binding]; other site 931276003375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276003376 dimer interface [polypeptide binding]; other site 931276003377 phosphorylation site [posttranslational modification] 931276003378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276003379 ATP binding site [chemical binding]; other site 931276003380 Mg2+ binding site [ion binding]; other site 931276003381 G-X-G motif; other site 931276003382 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 931276003383 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 931276003384 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 931276003385 EcsC protein family; Region: EcsC; pfam12787 931276003386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276003387 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276003388 substrate binding pocket [chemical binding]; other site 931276003389 membrane-bound complex binding site; other site 931276003390 hinge residues; other site 931276003391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276003392 dimer interface [polypeptide binding]; other site 931276003393 conserved gate region; other site 931276003394 putative PBP binding loops; other site 931276003395 ABC-ATPase subunit interface; other site 931276003396 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 931276003397 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276003398 Walker A/P-loop; other site 931276003399 ATP binding site [chemical binding]; other site 931276003400 Q-loop/lid; other site 931276003401 ABC transporter signature motif; other site 931276003402 Walker B; other site 931276003403 D-loop; other site 931276003404 H-loop/switch region; other site 931276003405 Probable zinc-binding domain; Region: zf-trcl; pfam13451 931276003406 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 931276003407 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 931276003408 Cl- selectivity filter; other site 931276003409 Cl- binding residues [ion binding]; other site 931276003410 pore gating glutamate residue; other site 931276003411 dimer interface [polypeptide binding]; other site 931276003412 H+/Cl- coupling transport residue; other site 931276003413 TrkA-C domain; Region: TrkA_C; pfam02080 931276003414 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276003415 EamA-like transporter family; Region: EamA; pfam00892 931276003416 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 931276003417 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 931276003418 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 931276003419 dimerization interface [polypeptide binding]; other site 931276003420 ATP binding site [chemical binding]; other site 931276003421 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 931276003422 dimerization interface [polypeptide binding]; other site 931276003423 ATP binding site [chemical binding]; other site 931276003424 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 931276003425 putative active site [active] 931276003426 catalytic triad [active] 931276003427 AIR carboxylase; Region: AIRC; pfam00731 931276003428 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 931276003429 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 931276003430 ATP binding site [chemical binding]; other site 931276003431 active site 931276003432 substrate binding site [chemical binding]; other site 931276003433 amidophosphoribosyltransferase; Provisional; Region: PRK05793 931276003434 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 931276003435 active site 931276003436 tetramer interface [polypeptide binding]; other site 931276003437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276003438 active site 931276003439 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 931276003440 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 931276003441 dimerization interface [polypeptide binding]; other site 931276003442 putative ATP binding site [chemical binding]; other site 931276003443 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 931276003444 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 931276003445 active site 931276003446 substrate binding site [chemical binding]; other site 931276003447 cosubstrate binding site; other site 931276003448 catalytic site [active] 931276003449 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 931276003450 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 931276003451 purine monophosphate binding site [chemical binding]; other site 931276003452 dimer interface [polypeptide binding]; other site 931276003453 putative catalytic residues [active] 931276003454 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 931276003455 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 931276003456 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 931276003457 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 931276003458 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 931276003459 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 931276003460 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 931276003461 active site 931276003462 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276003463 Penicillinase repressor; Region: Pencillinase_R; pfam03965 931276003464 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 931276003465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276003466 TPR motif; other site 931276003467 binding surface 931276003468 TPR repeat; Region: TPR_11; pfam13414 931276003469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276003470 binding surface 931276003471 TPR motif; other site 931276003472 TPR repeat; Region: TPR_11; pfam13414 931276003473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276003474 binding surface 931276003475 TPR repeat; Region: TPR_11; pfam13414 931276003476 TPR motif; other site 931276003477 TPR repeat; Region: TPR_11; pfam13414 931276003478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931276003479 binding surface 931276003480 TPR motif; other site 931276003481 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 931276003482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276003483 Coenzyme A binding pocket [chemical binding]; other site 931276003484 MarR family; Region: MarR_2; pfam12802 931276003485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276003486 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 931276003487 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 931276003488 dimer interface [polypeptide binding]; other site 931276003489 active site 931276003490 CoA binding pocket [chemical binding]; other site 931276003491 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 931276003492 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 931276003493 FMN binding site [chemical binding]; other site 931276003494 substrate binding site [chemical binding]; other site 931276003495 putative catalytic residue [active] 931276003496 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 931276003497 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 931276003498 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 931276003499 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 931276003500 NAD(P) binding site [chemical binding]; other site 931276003501 homotetramer interface [polypeptide binding]; other site 931276003502 homodimer interface [polypeptide binding]; other site 931276003503 active site 931276003504 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 931276003505 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 931276003506 dimer interface [polypeptide binding]; other site 931276003507 active site 931276003508 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 931276003509 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 931276003510 carboxyltransferase (CT) interaction site; other site 931276003511 biotinylation site [posttranslational modification]; other site 931276003512 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 931276003513 biotin carboxylase; Validated; Region: PRK05586 931276003514 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931276003515 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 931276003516 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 931276003517 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 931276003518 RNA polymerase subunit 9; Region: RPOL9; smart00661 931276003519 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 931276003520 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 931276003521 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 931276003522 hexamer interface [polypeptide binding]; other site 931276003523 RNA binding site [nucleotide binding]; other site 931276003524 Histidine-zinc binding site [chemical binding]; other site 931276003525 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 931276003526 zinc binding site [ion binding]; other site 931276003527 putative ligand binding site [chemical binding]; other site 931276003528 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276003529 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 931276003530 TM-ABC transporter signature motif; other site 931276003531 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 931276003532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276003533 Walker A/P-loop; other site 931276003534 ATP binding site [chemical binding]; other site 931276003535 Q-loop/lid; other site 931276003536 ABC transporter signature motif; other site 931276003537 Walker B; other site 931276003538 D-loop; other site 931276003539 H-loop/switch region; other site 931276003540 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 931276003541 Chain length determinant protein; Region: Wzz; cl15801 931276003542 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 931276003543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276003544 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 931276003545 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 931276003546 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931276003547 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 931276003548 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 931276003549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276003550 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 931276003551 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 931276003552 trimer interface [polypeptide binding]; other site 931276003553 active site 931276003554 substrate binding site [chemical binding]; other site 931276003555 CoA binding site [chemical binding]; other site 931276003556 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 931276003557 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 931276003558 putative glycosyl transferase; Provisional; Region: PRK10073 931276003559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931276003560 active site 931276003561 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 931276003562 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 931276003563 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 931276003564 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931276003565 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931276003566 active site 931276003567 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276003568 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276003569 Walker A/P-loop; other site 931276003570 ATP binding site [chemical binding]; other site 931276003571 Q-loop/lid; other site 931276003572 ABC transporter signature motif; other site 931276003573 Walker B; other site 931276003574 D-loop; other site 931276003575 H-loop/switch region; other site 931276003576 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276003577 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 931276003578 FtsX-like permease family; Region: FtsX; pfam02687 931276003579 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 931276003580 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 931276003581 Sensor protein DegS; Region: DegS; pfam05384 931276003582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 931276003583 Histidine kinase; Region: HisKA_3; pfam07730 931276003584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276003585 ATP binding site [chemical binding]; other site 931276003586 Mg2+ binding site [ion binding]; other site 931276003587 G-X-G motif; other site 931276003588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276003589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276003590 active site 931276003591 phosphorylation site [posttranslational modification] 931276003592 intermolecular recognition site; other site 931276003593 dimerization interface [polypeptide binding]; other site 931276003594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276003595 DNA binding residues [nucleotide binding] 931276003596 dimerization interface [polypeptide binding]; other site 931276003597 Chain length determinant protein; Region: Wzz; cl15801 931276003598 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 931276003599 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276003600 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276003601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276003602 DNA binding residues [nucleotide binding] 931276003603 dimerization interface [polypeptide binding]; other site 931276003604 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931276003605 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 931276003606 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 931276003607 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 931276003608 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 931276003609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276003610 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 931276003611 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 931276003612 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931276003613 4Fe-4S binding domain; Region: Fer4; pfam00037 931276003614 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 931276003615 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276003616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276003617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276003618 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 931276003619 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931276003620 Probable Catalytic site; other site 931276003621 metal-binding site 931276003622 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931276003623 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931276003624 active site 931276003625 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 931276003626 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 931276003627 substrate binding site; other site 931276003628 tetramer interface; other site 931276003629 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 931276003630 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 931276003631 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 931276003632 NADP binding site [chemical binding]; other site 931276003633 active site 931276003634 putative substrate binding site [chemical binding]; other site 931276003635 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 931276003636 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 931276003637 NAD binding site [chemical binding]; other site 931276003638 substrate binding site [chemical binding]; other site 931276003639 homodimer interface [polypeptide binding]; other site 931276003640 active site 931276003641 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276003642 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 931276003643 putative ADP-binding pocket [chemical binding]; other site 931276003644 colanic acid exporter; Provisional; Region: PRK10459 931276003645 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 931276003646 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 931276003647 Acyltransferase family; Region: Acyl_transf_3; pfam01757 931276003648 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 931276003649 Acyltransferase family; Region: Acyl_transf_3; pfam01757 931276003650 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 931276003651 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 931276003652 active site 931276003653 tetramer interface; other site 931276003654 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276003655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276003656 Walker A/P-loop; other site 931276003657 ATP binding site [chemical binding]; other site 931276003658 Q-loop/lid; other site 931276003659 ABC transporter signature motif; other site 931276003660 Walker B; other site 931276003661 D-loop; other site 931276003662 H-loop/switch region; other site 931276003663 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276003664 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 931276003665 FtsX-like permease family; Region: FtsX; pfam02687 931276003666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 931276003667 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276003668 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931276003669 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931276003670 putative active site [active] 931276003671 putative NTP binding site [chemical binding]; other site 931276003672 putative nucleic acid binding site [nucleotide binding]; other site 931276003673 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931276003674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276003675 Walker A motif; other site 931276003676 ATP binding site [chemical binding]; other site 931276003677 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 931276003678 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 931276003679 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 931276003680 NADP binding site [chemical binding]; other site 931276003681 active site 931276003682 putative substrate binding site [chemical binding]; other site 931276003683 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 931276003684 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 931276003685 NAD binding site [chemical binding]; other site 931276003686 substrate binding site [chemical binding]; other site 931276003687 homodimer interface [polypeptide binding]; other site 931276003688 active site 931276003689 Predicted integral membrane protein [Function unknown]; Region: COG5652 931276003690 recombination factor protein RarA; Reviewed; Region: PRK13342 931276003691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276003692 Walker A motif; other site 931276003693 ATP binding site [chemical binding]; other site 931276003694 Walker B motif; other site 931276003695 arginine finger; other site 931276003696 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 931276003697 Transcriptional regulator; Region: Rrf2; cl17282 931276003698 Rrf2 family protein; Region: rrf2_super; TIGR00738 931276003699 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 931276003700 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 931276003701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276003702 catalytic residue [active] 931276003703 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 931276003704 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 931276003705 trimerization site [polypeptide binding]; other site 931276003706 active site 931276003707 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 931276003708 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 931276003709 Ligand Binding Site [chemical binding]; other site 931276003710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 931276003711 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 931276003712 FAD binding site [chemical binding]; other site 931276003713 homotetramer interface [polypeptide binding]; other site 931276003714 substrate binding pocket [chemical binding]; other site 931276003715 catalytic base [active] 931276003716 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931276003717 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931276003718 Rubredoxin [Energy production and conversion]; Region: COG1773 931276003719 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 931276003720 iron binding site [ion binding]; other site 931276003721 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 931276003722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276003723 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276003724 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 931276003725 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931276003726 Domain of unknown function DUF20; Region: UPF0118; pfam01594 931276003727 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 931276003728 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 931276003729 motif 1; other site 931276003730 active site 931276003731 motif 2; other site 931276003732 motif 3; other site 931276003733 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 931276003734 DHHA1 domain; Region: DHHA1; pfam02272 931276003735 hypothetical protein; Provisional; Region: PRK05473 931276003736 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 931276003737 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 931276003738 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 931276003739 metal binding site 2 [ion binding]; metal-binding site 931276003740 putative DNA binding helix; other site 931276003741 metal binding site 1 [ion binding]; metal-binding site 931276003742 dimer interface [polypeptide binding]; other site 931276003743 structural Zn2+ binding site [ion binding]; other site 931276003744 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 931276003745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276003746 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 931276003747 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 931276003748 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 931276003749 G1 box; other site 931276003750 putative GEF interaction site [polypeptide binding]; other site 931276003751 GTP/Mg2+ binding site [chemical binding]; other site 931276003752 Switch I region; other site 931276003753 G2 box; other site 931276003754 G3 box; other site 931276003755 Switch II region; other site 931276003756 G4 box; other site 931276003757 G5 box; other site 931276003758 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 931276003759 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 931276003760 YceG-like family; Region: YceG; pfam02618 931276003761 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 931276003762 dimerization interface [polypeptide binding]; other site 931276003763 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 931276003764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276003765 S-adenosylmethionine binding site [chemical binding]; other site 931276003766 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 931276003767 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 931276003768 Peptidase family U32; Region: Peptidase_U32; pfam01136 931276003769 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 931276003770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 931276003771 sporulation sigma factor SigK; Reviewed; Region: PRK05803 931276003772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276003773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276003774 DNA binding residues [nucleotide binding] 931276003775 cell division protein FtsA; Region: ftsA; TIGR01174 931276003776 Cell division protein FtsA; Region: FtsA; smart00842 931276003777 Cell division protein FtsA; Region: FtsA; pfam14450 931276003778 cell division protein FtsZ; Validated; Region: PRK09330 931276003779 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 931276003780 nucleotide binding site [chemical binding]; other site 931276003781 SulA interaction site; other site 931276003782 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 931276003783 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 931276003784 sporulation sigma factor SigE; Reviewed; Region: PRK08301 931276003785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276003786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276003787 DNA binding residues [nucleotide binding] 931276003788 sporulation sigma factor SigG; Reviewed; Region: PRK08215 931276003789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276003790 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 931276003791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276003792 DNA binding residues [nucleotide binding] 931276003793 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 931276003794 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 931276003795 ATP cone domain; Region: ATP-cone; pfam03477 931276003796 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 931276003797 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 931276003798 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276003799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276003800 active site 931276003801 phosphorylation site [posttranslational modification] 931276003802 intermolecular recognition site; other site 931276003803 dimerization interface [polypeptide binding]; other site 931276003804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276003805 DNA binding site [nucleotide binding] 931276003806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276003807 dimerization interface [polypeptide binding]; other site 931276003808 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 931276003809 PAS domain; Region: PAS; smart00091 931276003810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276003811 dimer interface [polypeptide binding]; other site 931276003812 phosphorylation site [posttranslational modification] 931276003813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276003814 ATP binding site [chemical binding]; other site 931276003815 Mg2+ binding site [ion binding]; other site 931276003816 G-X-G motif; other site 931276003817 PBP superfamily domain; Region: PBP_like_2; cl17296 931276003818 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 931276003819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276003820 dimer interface [polypeptide binding]; other site 931276003821 conserved gate region; other site 931276003822 putative PBP binding loops; other site 931276003823 ABC-ATPase subunit interface; other site 931276003824 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 931276003825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276003826 dimer interface [polypeptide binding]; other site 931276003827 conserved gate region; other site 931276003828 putative PBP binding loops; other site 931276003829 ABC-ATPase subunit interface; other site 931276003830 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 931276003831 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 931276003832 Walker A/P-loop; other site 931276003833 ATP binding site [chemical binding]; other site 931276003834 Q-loop/lid; other site 931276003835 ABC transporter signature motif; other site 931276003836 Walker B; other site 931276003837 D-loop; other site 931276003838 H-loop/switch region; other site 931276003839 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 931276003840 PhoU domain; Region: PhoU; pfam01895 931276003841 PhoU domain; Region: PhoU; pfam01895 931276003842 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 931276003843 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 931276003844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 931276003845 FeS/SAM binding site; other site 931276003846 Protein of unknown function (DUF512); Region: DUF512; pfam04459 931276003847 GTP-binding protein Der; Reviewed; Region: PRK00093 931276003848 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 931276003849 G1 box; other site 931276003850 GTP/Mg2+ binding site [chemical binding]; other site 931276003851 Switch I region; other site 931276003852 G2 box; other site 931276003853 Switch II region; other site 931276003854 G3 box; other site 931276003855 G4 box; other site 931276003856 G5 box; other site 931276003857 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 931276003858 G1 box; other site 931276003859 GTP/Mg2+ binding site [chemical binding]; other site 931276003860 Switch I region; other site 931276003861 G2 box; other site 931276003862 G3 box; other site 931276003863 Switch II region; other site 931276003864 G4 box; other site 931276003865 G5 box; other site 931276003866 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 931276003867 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 931276003868 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 931276003869 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 931276003870 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 931276003871 hypothetical protein; Provisional; Region: PRK11820 931276003872 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 931276003873 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 931276003874 hypothetical protein; Provisional; Region: PRK04323 931276003875 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 931276003876 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 931276003877 catalytic site [active] 931276003878 G-X2-G-X-G-K; other site 931276003879 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 931276003880 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 931276003881 Flavoprotein; Region: Flavoprotein; pfam02441 931276003882 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 931276003883 primosome assembly protein PriA; Validated; Region: PRK05580 931276003884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276003885 ATP binding site [chemical binding]; other site 931276003886 putative Mg++ binding site [ion binding]; other site 931276003887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276003888 nucleotide binding region [chemical binding]; other site 931276003889 ATP-binding site [chemical binding]; other site 931276003890 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 931276003891 active site 931276003892 catalytic residues [active] 931276003893 metal binding site [ion binding]; metal-binding site 931276003894 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 931276003895 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 931276003896 putative active site [active] 931276003897 substrate binding site [chemical binding]; other site 931276003898 putative cosubstrate binding site; other site 931276003899 catalytic site [active] 931276003900 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 931276003901 substrate binding site [chemical binding]; other site 931276003902 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 931276003903 16S rRNA methyltransferase B; Provisional; Region: PRK14902 931276003904 NusB family; Region: NusB; pfam01029 931276003905 putative RNA binding site [nucleotide binding]; other site 931276003906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276003907 S-adenosylmethionine binding site [chemical binding]; other site 931276003908 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 931276003909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276003910 FeS/SAM binding site; other site 931276003911 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 931276003912 active site 931276003913 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 931276003914 Catalytic domain of Protein Kinases; Region: PKc; cd00180 931276003915 active site 931276003916 ATP binding site [chemical binding]; other site 931276003917 substrate binding site [chemical binding]; other site 931276003918 activation loop (A-loop); other site 931276003919 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 931276003920 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 931276003921 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 931276003922 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 931276003923 GTPase RsgA; Reviewed; Region: PRK00098 931276003924 RNA binding site [nucleotide binding]; other site 931276003925 homodimer interface [polypeptide binding]; other site 931276003926 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 931276003927 GTPase/Zn-binding domain interface [polypeptide binding]; other site 931276003928 GTP/Mg2+ binding site [chemical binding]; other site 931276003929 G4 box; other site 931276003930 G5 box; other site 931276003931 G1 box; other site 931276003932 Switch I region; other site 931276003933 G2 box; other site 931276003934 G3 box; other site 931276003935 Switch II region; other site 931276003936 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 931276003937 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 931276003938 substrate binding site [chemical binding]; other site 931276003939 hexamer interface [polypeptide binding]; other site 931276003940 metal binding site [ion binding]; metal-binding site 931276003941 Thiamine pyrophosphokinase; Region: TPK; cd07995 931276003942 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 931276003943 active site 931276003944 dimerization interface [polypeptide binding]; other site 931276003945 thiamine binding site [chemical binding]; other site 931276003946 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 931276003947 Asp23 family; Region: Asp23; pfam03780 931276003948 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 931276003949 DAK2 domain; Region: Dak2; pfam02734 931276003950 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 931276003951 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 931276003952 ssDNA binding site; other site 931276003953 generic binding surface II; other site 931276003954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276003955 ATP binding site [chemical binding]; other site 931276003956 putative Mg++ binding site [ion binding]; other site 931276003957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276003958 nucleotide binding region [chemical binding]; other site 931276003959 ATP-binding site [chemical binding]; other site 931276003960 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 931276003961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276003962 S-adenosylmethionine binding site [chemical binding]; other site 931276003963 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 931276003964 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 931276003965 active site 931276003966 (T/H)XGH motif; other site 931276003967 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 931276003968 Nucleoside recognition; Region: Gate; pfam07670 931276003969 hypothetical protein; Provisional; Region: PRK13670 931276003970 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 931276003971 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 931276003972 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 931276003973 propionate/acetate kinase; Provisional; Region: PRK12379 931276003974 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 931276003975 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 931276003976 putative phosphate acyltransferase; Provisional; Region: PRK05331 931276003977 acyl carrier protein; Provisional; Region: acpP; PRK00982 931276003978 ribonuclease III; Reviewed; Region: rnc; PRK00102 931276003979 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 931276003980 dimerization interface [polypeptide binding]; other site 931276003981 active site 931276003982 metal binding site [ion binding]; metal-binding site 931276003983 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 931276003984 dsRNA binding site [nucleotide binding]; other site 931276003985 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931276003986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276003987 FeS/SAM binding site; other site 931276003988 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 931276003989 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 931276003990 Walker A/P-loop; other site 931276003991 ATP binding site [chemical binding]; other site 931276003992 Q-loop/lid; other site 931276003993 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 931276003994 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 931276003995 ABC transporter signature motif; other site 931276003996 Walker B; other site 931276003997 D-loop; other site 931276003998 H-loop/switch region; other site 931276003999 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 931276004000 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 931276004001 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 931276004002 P loop; other site 931276004003 GTP binding site [chemical binding]; other site 931276004004 putative DNA-binding protein; Validated; Region: PRK00118 931276004005 signal recognition particle protein; Provisional; Region: PRK10867 931276004006 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 931276004007 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 931276004008 P loop; other site 931276004009 GTP binding site [chemical binding]; other site 931276004010 Signal peptide binding domain; Region: SRP_SPB; pfam02978 931276004011 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 931276004012 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 931276004013 hypothetical protein; Provisional; Region: PRK00468 931276004014 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 931276004015 RimM N-terminal domain; Region: RimM; pfam01782 931276004016 PRC-barrel domain; Region: PRC; pfam05239 931276004017 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 931276004018 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 931276004019 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 931276004020 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 931276004021 GTP/Mg2+ binding site [chemical binding]; other site 931276004022 G4 box; other site 931276004023 G5 box; other site 931276004024 G1 box; other site 931276004025 Switch I region; other site 931276004026 G2 box; other site 931276004027 G3 box; other site 931276004028 Switch II region; other site 931276004029 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 931276004030 RNA/DNA hybrid binding site [nucleotide binding]; other site 931276004031 active site 931276004032 hypothetical protein; Reviewed; Region: PRK12497 931276004033 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 931276004034 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 931276004035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276004036 Walker A motif; other site 931276004037 ATP binding site [chemical binding]; other site 931276004038 Walker B motif; other site 931276004039 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 931276004040 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 931276004041 DNA protecting protein DprA; Region: dprA; TIGR00732 931276004042 DNA topoisomerase I; Validated; Region: PRK05582 931276004043 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 931276004044 active site 931276004045 interdomain interaction site; other site 931276004046 putative metal-binding site [ion binding]; other site 931276004047 nucleotide binding site [chemical binding]; other site 931276004048 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 931276004049 domain I; other site 931276004050 DNA binding groove [nucleotide binding] 931276004051 phosphate binding site [ion binding]; other site 931276004052 domain II; other site 931276004053 domain III; other site 931276004054 nucleotide binding site [chemical binding]; other site 931276004055 catalytic site [active] 931276004056 domain IV; other site 931276004057 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 931276004058 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 931276004059 transcriptional repressor CodY; Validated; Region: PRK04158 931276004060 CodY GAF-like domain; Region: CodY; pfam06018 931276004061 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 931276004062 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 931276004063 rRNA interaction site [nucleotide binding]; other site 931276004064 S8 interaction site; other site 931276004065 putative laminin-1 binding site; other site 931276004066 elongation factor Ts; Provisional; Region: tsf; PRK09377 931276004067 UBA/TS-N domain; Region: UBA; pfam00627 931276004068 Elongation factor TS; Region: EF_TS; pfam00889 931276004069 Elongation factor TS; Region: EF_TS; pfam00889 931276004070 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 931276004071 putative nucleotide binding site [chemical binding]; other site 931276004072 uridine monophosphate binding site [chemical binding]; other site 931276004073 homohexameric interface [polypeptide binding]; other site 931276004074 ribosome recycling factor; Reviewed; Region: frr; PRK00083 931276004075 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 931276004076 hinge region; other site 931276004077 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 931276004078 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 931276004079 catalytic residue [active] 931276004080 putative FPP diphosphate binding site; other site 931276004081 putative FPP binding hydrophobic cleft; other site 931276004082 dimer interface [polypeptide binding]; other site 931276004083 putative IPP diphosphate binding site; other site 931276004084 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 931276004085 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 931276004086 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 931276004087 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 931276004088 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 931276004089 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 931276004090 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 931276004091 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 931276004092 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 931276004093 active site 931276004094 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 931276004095 protein binding site [polypeptide binding]; other site 931276004096 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 931276004097 putative substrate binding region [chemical binding]; other site 931276004098 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 931276004099 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 931276004100 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 931276004101 ribosome maturation protein RimP; Reviewed; Region: PRK00092 931276004102 Sm and related proteins; Region: Sm_like; cl00259 931276004103 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 931276004104 putative oligomer interface [polypeptide binding]; other site 931276004105 putative RNA binding site [nucleotide binding]; other site 931276004106 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 931276004107 NusA N-terminal domain; Region: NusA_N; pfam08529 931276004108 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 931276004109 RNA binding site [nucleotide binding]; other site 931276004110 homodimer interface [polypeptide binding]; other site 931276004111 NusA-like KH domain; Region: KH_5; pfam13184 931276004112 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 931276004113 G-X-X-G motif; other site 931276004114 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 931276004115 putative RNA binding cleft [nucleotide binding]; other site 931276004116 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 931276004117 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 931276004118 translation initiation factor IF-2; Region: IF-2; TIGR00487 931276004119 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 931276004120 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 931276004121 G1 box; other site 931276004122 putative GEF interaction site [polypeptide binding]; other site 931276004123 GTP/Mg2+ binding site [chemical binding]; other site 931276004124 Switch I region; other site 931276004125 G2 box; other site 931276004126 G3 box; other site 931276004127 Switch II region; other site 931276004128 G4 box; other site 931276004129 G5 box; other site 931276004130 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 931276004131 Translation-initiation factor 2; Region: IF-2; pfam11987 931276004132 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 931276004133 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 931276004134 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 931276004135 DHH family; Region: DHH; pfam01368 931276004136 DHHA1 domain; Region: DHHA1; pfam02272 931276004137 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 931276004138 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 931276004139 RNA binding site [nucleotide binding]; other site 931276004140 active site 931276004141 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 931276004142 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 931276004143 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 931276004144 active site 931276004145 Riboflavin kinase; Region: Flavokinase; smart00904 931276004146 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 931276004147 16S/18S rRNA binding site [nucleotide binding]; other site 931276004148 S13e-L30e interaction site [polypeptide binding]; other site 931276004149 25S rRNA binding site [nucleotide binding]; other site 931276004150 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 931276004151 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 931276004152 RNase E interface [polypeptide binding]; other site 931276004153 trimer interface [polypeptide binding]; other site 931276004154 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 931276004155 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 931276004156 RNase E interface [polypeptide binding]; other site 931276004157 trimer interface [polypeptide binding]; other site 931276004158 active site 931276004159 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 931276004160 putative nucleic acid binding region [nucleotide binding]; other site 931276004161 G-X-X-G motif; other site 931276004162 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 931276004163 RNA binding site [nucleotide binding]; other site 931276004164 domain interface; other site 931276004165 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 931276004166 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 931276004167 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 931276004168 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 931276004169 aspartate kinase I; Reviewed; Region: PRK08210 931276004170 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 931276004171 nucleotide binding site [chemical binding]; other site 931276004172 substrate binding site [chemical binding]; other site 931276004173 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 931276004174 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 931276004175 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 931276004176 active site 931276004177 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 931276004178 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 931276004179 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 931276004180 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 931276004181 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 931276004182 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 931276004183 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 931276004184 recombinase A; Provisional; Region: recA; PRK09354 931276004185 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 931276004186 hexamer interface [polypeptide binding]; other site 931276004187 Walker A motif; other site 931276004188 ATP binding site [chemical binding]; other site 931276004189 Walker B motif; other site 931276004190 phosphodiesterase; Provisional; Region: PRK12704 931276004191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276004192 Zn2+ binding site [ion binding]; other site 931276004193 Mg2+ binding site [ion binding]; other site 931276004194 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 931276004195 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 931276004196 dimerization domain swap beta strand [polypeptide binding]; other site 931276004197 regulatory protein interface [polypeptide binding]; other site 931276004198 active site 931276004199 regulatory phosphorylation site [posttranslational modification]; other site 931276004200 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 931276004201 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 931276004202 tetramer interface [polypeptide binding]; other site 931276004203 active site 931276004204 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931276004205 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931276004206 putative active site [active] 931276004207 putative NTP binding site [chemical binding]; other site 931276004208 putative nucleic acid binding site [nucleotide binding]; other site 931276004209 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931276004210 Putative amidase domain; Region: Amidase_6; pfam12671 931276004211 Suppression of tumorigenicity 7; Region: ST7; cd11557 931276004212 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 931276004213 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 931276004214 catalytic motif [active] 931276004215 Zn binding site [ion binding]; other site 931276004216 RibD C-terminal domain; Region: RibD_C; cl17279 931276004217 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 931276004218 Lumazine binding domain; Region: Lum_binding; pfam00677 931276004219 Lumazine binding domain; Region: Lum_binding; pfam00677 931276004220 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 931276004221 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 931276004222 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 931276004223 dimerization interface [polypeptide binding]; other site 931276004224 active site 931276004225 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 931276004226 homopentamer interface [polypeptide binding]; other site 931276004227 active site 931276004228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 931276004229 Syntaxin; Region: Syntaxin; pfam00804 931276004230 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 931276004231 NlpC/P60 family; Region: NLPC_P60; pfam00877 931276004232 K+ potassium transporter; Region: K_trans; pfam02705 931276004233 K+ potassium transporter; Region: K_trans; pfam02705 931276004234 hypothetical protein; Provisional; Region: PRK03881 931276004235 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 931276004236 AMMECR1; Region: AMMECR1; pfam01871 931276004237 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 931276004238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276004239 FeS/SAM binding site; other site 931276004240 FIST N domain; Region: FIST; pfam08495 931276004241 FIST C domain; Region: FIST_C; pfam10442 931276004242 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276004243 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 931276004244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276004245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276004246 Coenzyme A binding pocket [chemical binding]; other site 931276004247 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276004248 MarR family; Region: MarR_2; pfam12802 931276004249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276004250 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276004251 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931276004252 Beta-lactamase; Region: Beta-lactamase; pfam00144 931276004253 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 931276004254 Peptidase family M50; Region: Peptidase_M50; pfam02163 931276004255 active site 931276004256 putative substrate binding region [chemical binding]; other site 931276004257 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931276004258 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931276004259 dimer interface [polypeptide binding]; other site 931276004260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004261 catalytic residue [active] 931276004262 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 931276004263 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 931276004264 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 931276004265 putative dimer interface [polypeptide binding]; other site 931276004266 N-terminal domain interface [polypeptide binding]; other site 931276004267 putative substrate binding pocket (H-site) [chemical binding]; other site 931276004268 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931276004269 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 931276004270 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931276004271 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 931276004272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004273 dimer interface [polypeptide binding]; other site 931276004274 conserved gate region; other site 931276004275 putative PBP binding loops; other site 931276004276 ABC-ATPase subunit interface; other site 931276004277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 931276004278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004279 dimer interface [polypeptide binding]; other site 931276004280 conserved gate region; other site 931276004281 putative PBP binding loops; other site 931276004282 ABC-ATPase subunit interface; other site 931276004283 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931276004284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276004285 Walker A/P-loop; other site 931276004286 ATP binding site [chemical binding]; other site 931276004287 Q-loop/lid; other site 931276004288 ABC transporter signature motif; other site 931276004289 Walker B; other site 931276004290 D-loop; other site 931276004291 H-loop/switch region; other site 931276004292 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276004293 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 931276004294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276004295 Walker A/P-loop; other site 931276004296 ATP binding site [chemical binding]; other site 931276004297 Q-loop/lid; other site 931276004298 ABC transporter signature motif; other site 931276004299 Walker B; other site 931276004300 D-loop; other site 931276004301 H-loop/switch region; other site 931276004302 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276004303 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 931276004304 peptidase T-like protein; Region: PepT-like; TIGR01883 931276004305 metal binding site [ion binding]; metal-binding site 931276004306 putative dimer interface [polypeptide binding]; other site 931276004307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276004308 Coenzyme A binding pocket [chemical binding]; other site 931276004309 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 931276004310 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 931276004311 substrate binding site [chemical binding]; other site 931276004312 THF binding site; other site 931276004313 zinc-binding site [ion binding]; other site 931276004314 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 931276004315 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 931276004316 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 931276004317 putative dimer interface [polypeptide binding]; other site 931276004318 N-terminal domain interface [polypeptide binding]; other site 931276004319 putative substrate binding pocket (H-site) [chemical binding]; other site 931276004320 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 931276004321 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 931276004322 putative dimer interface [polypeptide binding]; other site 931276004323 N-terminal domain interface [polypeptide binding]; other site 931276004324 putative substrate binding pocket (H-site) [chemical binding]; other site 931276004325 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276004326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276004327 substrate binding pocket [chemical binding]; other site 931276004328 membrane-bound complex binding site; other site 931276004329 hinge residues; other site 931276004330 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931276004331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004332 dimer interface [polypeptide binding]; other site 931276004333 conserved gate region; other site 931276004334 putative PBP binding loops; other site 931276004335 ABC-ATPase subunit interface; other site 931276004336 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276004337 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276004338 Walker A/P-loop; other site 931276004339 ATP binding site [chemical binding]; other site 931276004340 Q-loop/lid; other site 931276004341 ABC transporter signature motif; other site 931276004342 Walker B; other site 931276004343 D-loop; other site 931276004344 H-loop/switch region; other site 931276004345 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 931276004346 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 931276004347 putative dimer interface [polypeptide binding]; other site 931276004348 N-terminal domain interface [polypeptide binding]; other site 931276004349 putative substrate binding pocket (H-site) [chemical binding]; other site 931276004350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276004351 Coenzyme A binding pocket [chemical binding]; other site 931276004352 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276004353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276004354 substrate binding pocket [chemical binding]; other site 931276004355 membrane-bound complex binding site; other site 931276004356 hinge residues; other site 931276004357 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 931276004358 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 931276004359 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 931276004360 metal binding site [ion binding]; metal-binding site 931276004361 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 931276004362 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 931276004363 metal binding site [ion binding]; metal-binding site 931276004364 dimer interface [polypeptide binding]; other site 931276004365 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276004366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276004367 substrate binding pocket [chemical binding]; other site 931276004368 membrane-bound complex binding site; other site 931276004369 hinge residues; other site 931276004370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004371 dimer interface [polypeptide binding]; other site 931276004372 conserved gate region; other site 931276004373 putative PBP binding loops; other site 931276004374 ABC-ATPase subunit interface; other site 931276004375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004376 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931276004377 dimer interface [polypeptide binding]; other site 931276004378 conserved gate region; other site 931276004379 putative PBP binding loops; other site 931276004380 ABC-ATPase subunit interface; other site 931276004381 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276004382 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276004383 Walker A/P-loop; other site 931276004384 ATP binding site [chemical binding]; other site 931276004385 Q-loop/lid; other site 931276004386 ABC transporter signature motif; other site 931276004387 Walker B; other site 931276004388 D-loop; other site 931276004389 H-loop/switch region; other site 931276004390 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276004391 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276004392 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276004393 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276004394 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 931276004395 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276004396 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276004397 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276004398 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276004399 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 931276004400 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 931276004401 active site 931276004402 zinc binding site [ion binding]; other site 931276004403 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 931276004404 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276004405 substrate binding pocket [chemical binding]; other site 931276004406 membrane-bound complex binding site; other site 931276004407 hinge residues; other site 931276004408 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931276004409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004410 putative PBP binding loops; other site 931276004411 dimer interface [polypeptide binding]; other site 931276004412 ABC-ATPase subunit interface; other site 931276004413 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 931276004414 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931276004415 Walker A/P-loop; other site 931276004416 ATP binding site [chemical binding]; other site 931276004417 Q-loop/lid; other site 931276004418 ABC transporter signature motif; other site 931276004419 Walker B; other site 931276004420 D-loop; other site 931276004421 H-loop/switch region; other site 931276004422 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 931276004423 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276004424 active site 931276004425 NAD binding site [chemical binding]; other site 931276004426 metal binding site [ion binding]; metal-binding site 931276004427 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 931276004428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276004429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004430 homodimer interface [polypeptide binding]; other site 931276004431 catalytic residue [active] 931276004432 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276004433 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 931276004434 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276004435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 931276004436 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 931276004437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 931276004438 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 931276004439 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 931276004440 Ligand Binding Site [chemical binding]; other site 931276004441 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 931276004442 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 931276004443 nitrogenase iron protein; Region: nifH; TIGR01287 931276004444 Nucleotide-binding sites [chemical binding]; other site 931276004445 Walker A motif; other site 931276004446 Switch I region of nucleotide binding site; other site 931276004447 Fe4S4 binding sites [ion binding]; other site 931276004448 Switch II region of nucleotide binding site; other site 931276004449 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276004450 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 931276004451 Walker A/P-loop; other site 931276004452 ATP binding site [chemical binding]; other site 931276004453 Q-loop/lid; other site 931276004454 ABC transporter signature motif; other site 931276004455 Walker B; other site 931276004456 D-loop; other site 931276004457 H-loop/switch region; other site 931276004458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004459 conserved gate region; other site 931276004460 ABC-ATPase subunit interface; other site 931276004461 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 931276004462 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 931276004463 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 931276004464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276004465 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931276004466 FeS/SAM binding site; other site 931276004467 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 931276004468 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 931276004469 homodimer interface [polypeptide binding]; other site 931276004470 substrate-cofactor binding pocket; other site 931276004471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004472 catalytic residue [active] 931276004473 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931276004474 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931276004475 dimer interface [polypeptide binding]; other site 931276004476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004477 catalytic residue [active] 931276004478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 931276004479 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931276004480 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 931276004481 peptide binding site [polypeptide binding]; other site 931276004482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931276004483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004484 dimer interface [polypeptide binding]; other site 931276004485 conserved gate region; other site 931276004486 putative PBP binding loops; other site 931276004487 ABC-ATPase subunit interface; other site 931276004488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 931276004489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276004490 dimer interface [polypeptide binding]; other site 931276004491 conserved gate region; other site 931276004492 putative PBP binding loops; other site 931276004493 ABC-ATPase subunit interface; other site 931276004494 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931276004495 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276004496 Walker A/P-loop; other site 931276004497 ATP binding site [chemical binding]; other site 931276004498 Q-loop/lid; other site 931276004499 ABC transporter signature motif; other site 931276004500 Walker B; other site 931276004501 D-loop; other site 931276004502 H-loop/switch region; other site 931276004503 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276004504 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 931276004505 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276004506 Walker A/P-loop; other site 931276004507 ATP binding site [chemical binding]; other site 931276004508 Q-loop/lid; other site 931276004509 ABC transporter signature motif; other site 931276004510 Walker B; other site 931276004511 D-loop; other site 931276004512 H-loop/switch region; other site 931276004513 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276004514 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 931276004515 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 931276004516 catalytic triad [active] 931276004517 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 931276004518 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 931276004519 catalytic triad [active] 931276004520 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 931276004521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276004522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276004523 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276004524 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931276004525 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 931276004526 seryl-tRNA synthetase; Provisional; Region: PRK05431 931276004527 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 931276004528 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 931276004529 motif 1; other site 931276004530 dimer interface [polypeptide binding]; other site 931276004531 active site 931276004532 motif 2; other site 931276004533 motif 3; other site 931276004534 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 931276004535 active site 931276004536 SAM binding site [chemical binding]; other site 931276004537 homodimer interface [polypeptide binding]; other site 931276004538 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 931276004539 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 931276004540 Predicted transcriptional regulator [Transcription]; Region: COG3888 931276004541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276004542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276004543 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 931276004544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276004545 Walker A motif; other site 931276004546 ATP binding site [chemical binding]; other site 931276004547 Walker B motif; other site 931276004548 arginine finger; other site 931276004549 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 931276004550 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 931276004551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276004552 S-adenosylmethionine binding site [chemical binding]; other site 931276004553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276004554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276004555 Coenzyme A binding pocket [chemical binding]; other site 931276004556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276004557 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 931276004558 HTH domain; Region: HTH_11; pfam08279 931276004559 HTH domain; Region: HTH_11; pfam08279 931276004560 PRD domain; Region: PRD; pfam00874 931276004561 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 931276004562 active site 931276004563 P-loop; other site 931276004564 phosphorylation site [posttranslational modification] 931276004565 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276004566 beta-galactosidase; Region: BGL; TIGR03356 931276004567 hypothetical protein; Provisional; Region: PRK05415 931276004568 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 931276004569 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931276004570 active site 931276004571 catalytic tetrad [active] 931276004572 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276004573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276004574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931276004575 catalytic core [active] 931276004576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931276004577 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 931276004578 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 931276004579 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 931276004580 putative dimer interface [polypeptide binding]; other site 931276004581 active site pocket [active] 931276004582 putative cataytic base [active] 931276004583 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 931276004584 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931276004585 ATP binding site [chemical binding]; other site 931276004586 Walker B motif; other site 931276004587 cobalamin synthase; Reviewed; Region: cobS; PRK00235 931276004588 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 931276004589 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 931276004590 catalytic core [active] 931276004591 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 931276004592 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 931276004593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276004594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004595 homodimer interface [polypeptide binding]; other site 931276004596 catalytic residue [active] 931276004597 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 931276004598 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 931276004599 Ligand Binding Site [chemical binding]; other site 931276004600 cobyric acid synthase; Provisional; Region: PRK00784 931276004601 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276004602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276004603 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 931276004604 catalytic triad [active] 931276004605 Response regulator receiver domain; Region: Response_reg; pfam00072 931276004606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276004607 active site 931276004608 phosphorylation site [posttranslational modification] 931276004609 intermolecular recognition site; other site 931276004610 dimerization interface [polypeptide binding]; other site 931276004611 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 931276004612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276004613 active site 931276004614 phosphorylation site [posttranslational modification] 931276004615 intermolecular recognition site; other site 931276004616 dimerization interface [polypeptide binding]; other site 931276004617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276004618 Zn2+ binding site [ion binding]; other site 931276004619 Mg2+ binding site [ion binding]; other site 931276004620 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 931276004621 Domain of unknown function DUF; Region: DUF204; pfam02659 931276004622 sugar phosphate phosphatase; Provisional; Region: PRK10513 931276004623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276004624 active site 931276004625 motif I; other site 931276004626 motif II; other site 931276004627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276004628 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276004629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276004630 Zn2+ binding site [ion binding]; other site 931276004631 Mg2+ binding site [ion binding]; other site 931276004632 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 931276004633 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931276004634 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 931276004635 active site 931276004636 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 931276004637 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 931276004638 Homoserine O-succinyltransferase; Region: HTS; pfam04204 931276004639 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 931276004640 proposed active site lysine [active] 931276004641 conserved cys residue [active] 931276004642 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 931276004643 Predicted membrane protein [General function prediction only]; Region: COG4194 931276004644 Predicted membrane protein [Function unknown]; Region: COG3326 931276004645 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 931276004646 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 931276004647 catalytic residue [active] 931276004648 putative FPP diphosphate binding site; other site 931276004649 putative FPP binding hydrophobic cleft; other site 931276004650 dimer interface [polypeptide binding]; other site 931276004651 putative IPP diphosphate binding site; other site 931276004652 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 931276004653 Flavin Reductases; Region: FlaRed; cl00801 931276004654 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276004655 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276004656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276004657 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 931276004658 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 931276004659 tRNA; other site 931276004660 putative tRNA binding site [nucleotide binding]; other site 931276004661 putative NADP binding site [chemical binding]; other site 931276004662 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 931276004663 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 931276004664 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 931276004665 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 931276004666 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 931276004667 domain interfaces; other site 931276004668 active site 931276004669 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 931276004670 active site 931276004671 SAM binding site [chemical binding]; other site 931276004672 homodimer interface [polypeptide binding]; other site 931276004673 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 931276004674 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 931276004675 active site 931276004676 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 931276004677 dimer interface [polypeptide binding]; other site 931276004678 active site 931276004679 Schiff base residues; other site 931276004680 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 931276004681 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931276004682 inhibitor-cofactor binding pocket; inhibition site 931276004683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004684 catalytic residue [active] 931276004685 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 931276004686 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 931276004687 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 931276004688 substrate binding site [chemical binding]; other site 931276004689 active site 931276004690 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 931276004691 metal binding site [ion binding]; metal-binding site 931276004692 ligand binding site [chemical binding]; other site 931276004693 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 931276004694 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 931276004695 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 931276004696 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 931276004697 active site 931276004698 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 931276004699 Putative esterase; Region: Esterase; pfam00756 931276004700 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276004701 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 931276004702 putative active site [active] 931276004703 putative metal binding site [ion binding]; other site 931276004704 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 931276004705 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276004706 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276004707 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 931276004708 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 931276004709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004710 catalytic residue [active] 931276004711 homoserine kinase; Provisional; Region: PRK01212 931276004712 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 931276004713 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 931276004714 hypothetical protein; Provisional; Region: PRK04435 931276004715 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 931276004716 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 931276004717 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 931276004718 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 931276004719 Domain of unknown function DUF21; Region: DUF21; pfam01595 931276004720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 931276004721 Transporter associated domain; Region: CorC_HlyC; pfam03471 931276004722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 931276004723 SPFH domain / Band 7 family; Region: Band_7; pfam01145 931276004724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276004725 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 931276004726 Walker A/P-loop; other site 931276004727 ATP binding site [chemical binding]; other site 931276004728 Q-loop/lid; other site 931276004729 ABC transporter signature motif; other site 931276004730 Walker B; other site 931276004731 D-loop; other site 931276004732 H-loop/switch region; other site 931276004733 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 931276004734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276004735 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 931276004736 dimerization interface [polypeptide binding]; other site 931276004737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276004738 dimer interface [polypeptide binding]; other site 931276004739 phosphorylation site [posttranslational modification] 931276004740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276004741 ATP binding site [chemical binding]; other site 931276004742 Mg2+ binding site [ion binding]; other site 931276004743 G-X-G motif; other site 931276004744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276004745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276004746 active site 931276004747 phosphorylation site [posttranslational modification] 931276004748 intermolecular recognition site; other site 931276004749 dimerization interface [polypeptide binding]; other site 931276004750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276004751 DNA binding site [nucleotide binding] 931276004752 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 931276004753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276004754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276004755 putative substrate translocation pore; other site 931276004756 RNA polymerase factor sigma-70; Validated; Region: PRK06811 931276004757 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276004758 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 931276004759 DNA binding residues [nucleotide binding] 931276004760 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06452 931276004761 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276004762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276004763 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 931276004764 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 931276004765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276004766 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931276004767 Flavodoxin domain; Region: Flavodoxin_5; cl17428 931276004768 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 931276004769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276004770 DNA binding residues [nucleotide binding] 931276004771 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276004772 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 931276004773 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931276004774 synthetase active site [active] 931276004775 NTP binding site [chemical binding]; other site 931276004776 metal binding site [ion binding]; metal-binding site 931276004777 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 931276004778 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276004779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276004780 Zn2+ binding site [ion binding]; other site 931276004781 Mg2+ binding site [ion binding]; other site 931276004782 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 931276004783 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 931276004784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276004785 catalytic residue [active] 931276004786 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 931276004787 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 931276004788 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 931276004789 Ligand Binding Site [chemical binding]; other site 931276004790 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 931276004791 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 931276004792 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 931276004793 dimer interface [polypeptide binding]; other site 931276004794 motif 1; other site 931276004795 active site 931276004796 motif 2; other site 931276004797 motif 3; other site 931276004798 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 931276004799 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 931276004800 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 931276004801 histidinol dehydrogenase; Region: hisD; TIGR00069 931276004802 NAD binding site [chemical binding]; other site 931276004803 dimerization interface [polypeptide binding]; other site 931276004804 product binding site; other site 931276004805 substrate binding site [chemical binding]; other site 931276004806 zinc binding site [ion binding]; other site 931276004807 catalytic residues [active] 931276004808 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 931276004809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276004810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276004811 homodimer interface [polypeptide binding]; other site 931276004812 catalytic residue [active] 931276004813 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 931276004814 putative active site pocket [active] 931276004815 4-fold oligomerization interface [polypeptide binding]; other site 931276004816 metal binding residues [ion binding]; metal-binding site 931276004817 3-fold/trimer interface [polypeptide binding]; other site 931276004818 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 931276004819 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 931276004820 putative active site [active] 931276004821 oxyanion strand; other site 931276004822 catalytic triad [active] 931276004823 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 931276004824 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 931276004825 catalytic residues [active] 931276004826 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 931276004827 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 931276004828 substrate binding site [chemical binding]; other site 931276004829 glutamase interaction surface [polypeptide binding]; other site 931276004830 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 931276004831 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 931276004832 metal binding site [ion binding]; metal-binding site 931276004833 trigger factor; Provisional; Region: tig; PRK01490 931276004834 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 931276004835 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 931276004836 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 931276004837 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 931276004838 oligomer interface [polypeptide binding]; other site 931276004839 active site residues [active] 931276004840 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 931276004841 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 931276004842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276004843 Walker A motif; other site 931276004844 ATP binding site [chemical binding]; other site 931276004845 Walker B motif; other site 931276004846 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 931276004847 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 931276004848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276004849 Walker A motif; other site 931276004850 ATP binding site [chemical binding]; other site 931276004851 Walker B motif; other site 931276004852 arginine finger; other site 931276004853 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 931276004854 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 931276004855 Found in ATP-dependent protease La (LON); Region: LON; smart00464 931276004856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276004857 Walker A motif; other site 931276004858 ATP binding site [chemical binding]; other site 931276004859 Walker B motif; other site 931276004860 arginine finger; other site 931276004861 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 931276004862 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 931276004863 G1 box; other site 931276004864 GTP/Mg2+ binding site [chemical binding]; other site 931276004865 Switch I region; other site 931276004866 G2 box; other site 931276004867 G3 box; other site 931276004868 Switch II region; other site 931276004869 G4 box; other site 931276004870 G5 box; other site 931276004871 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 931276004872 metal binding site 2 [ion binding]; metal-binding site 931276004873 putative DNA binding helix; other site 931276004874 metal binding site 1 [ion binding]; metal-binding site 931276004875 dimer interface [polypeptide binding]; other site 931276004876 structural Zn2+ binding site [ion binding]; other site 931276004877 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 931276004878 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 931276004879 active site 931276004880 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 931276004881 Part of AAA domain; Region: AAA_19; pfam13245 931276004882 Family description; Region: UvrD_C_2; pfam13538 931276004883 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931276004884 cell division protein FtsA; Region: ftsA; TIGR01174 931276004885 Cell division protein FtsA; Region: FtsA; smart00842 931276004886 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931276004887 nucleotide binding site [chemical binding]; other site 931276004888 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 931276004889 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 931276004890 metal binding site [ion binding]; metal-binding site 931276004891 dimer interface [polypeptide binding]; other site 931276004892 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 931276004893 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 931276004894 active site 931276004895 stage V sporulation protein B; Region: spore_V_B; TIGR02900 931276004896 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 931276004897 stage V sporulation protein B; Region: spore_V_B; TIGR02900 931276004898 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931276004899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276004900 putative CheW interface [polypeptide binding]; other site 931276004901 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 931276004902 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 931276004903 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 931276004904 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 931276004905 HSP70 interaction site [polypeptide binding]; other site 931276004906 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 931276004907 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 931276004908 phosphopeptide binding site; other site 931276004909 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 931276004910 active site 931276004911 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 931276004912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931276004913 nucleotide binding site [chemical binding]; other site 931276004914 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276004915 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 931276004916 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276004917 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931276004918 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931276004919 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 931276004920 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 931276004921 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276004922 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 931276004923 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 931276004924 RHS Repeat; Region: RHS_repeat; cl11982 931276004925 RHS Repeat; Region: RHS_repeat; pfam05593 931276004926 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 931276004927 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 931276004928 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 931276004929 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 931276004930 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 931276004931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276004932 Walker A motif; other site 931276004933 ATP binding site [chemical binding]; other site 931276004934 Walker B motif; other site 931276004935 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276004936 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 931276004937 Uncharacterized conserved protein [Function unknown]; Region: COG1284 931276004938 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 931276004939 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 931276004940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276004941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276004942 WHG domain; Region: WHG; pfam13305 931276004943 FMN-binding domain; Region: FMN_bind; cl01081 931276004944 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 931276004945 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931276004946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276004947 FeS/SAM binding site; other site 931276004948 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 931276004949 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276004950 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931276004951 DNA binding residues [nucleotide binding] 931276004952 drug binding residues [chemical binding]; other site 931276004953 dimer interface [polypeptide binding]; other site 931276004954 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276004955 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276004956 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276004957 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276004958 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276004959 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931276004960 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 931276004961 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 931276004962 Penicillinase repressor; Region: Pencillinase_R; pfam03965 931276004963 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 931276004964 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 931276004965 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 931276004966 Mg++ binding site [ion binding]; other site 931276004967 putative catalytic motif [active] 931276004968 substrate binding site [chemical binding]; other site 931276004969 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931276004970 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 931276004971 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 931276004972 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931276004973 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 931276004974 substrate binding pocket [chemical binding]; other site 931276004975 dimer interface [polypeptide binding]; other site 931276004976 inhibitor binding site; inhibition site 931276004977 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931276004978 B12 binding site [chemical binding]; other site 931276004979 cobalt ligand [ion binding]; other site 931276004980 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 931276004981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276004982 Beta-Casp domain; Region: Beta-Casp; smart01027 931276004983 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 931276004984 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 931276004985 Amb_all domain; Region: Amb_all; smart00656 931276004986 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 931276004987 Predicted permeases [General function prediction only]; Region: COG0679 931276004988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276004989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276004990 ATP binding site [chemical binding]; other site 931276004991 G-X-G motif; other site 931276004992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276004993 Response regulator receiver domain; Region: Response_reg; pfam00072 931276004994 active site 931276004995 phosphorylation site [posttranslational modification] 931276004996 intermolecular recognition site; other site 931276004997 dimerization interface [polypeptide binding]; other site 931276004998 YcbB domain; Region: YcbB; pfam08664 931276004999 acetolactate synthase; Reviewed; Region: PRK08322 931276005000 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931276005001 PYR/PP interface [polypeptide binding]; other site 931276005002 dimer interface [polypeptide binding]; other site 931276005003 TPP binding site [chemical binding]; other site 931276005004 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 931276005005 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 931276005006 TPP-binding site [chemical binding]; other site 931276005007 dimer interface [polypeptide binding]; other site 931276005008 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276005009 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276005010 Walker A/P-loop; other site 931276005011 ATP binding site [chemical binding]; other site 931276005012 Q-loop/lid; other site 931276005013 ABC transporter signature motif; other site 931276005014 Walker B; other site 931276005015 D-loop; other site 931276005016 H-loop/switch region; other site 931276005017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276005018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276005019 substrate binding pocket [chemical binding]; other site 931276005020 membrane-bound complex binding site; other site 931276005021 hinge residues; other site 931276005022 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931276005023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276005024 dimer interface [polypeptide binding]; other site 931276005025 conserved gate region; other site 931276005026 putative PBP binding loops; other site 931276005027 ABC-ATPase subunit interface; other site 931276005028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276005029 dimer interface [polypeptide binding]; other site 931276005030 conserved gate region; other site 931276005031 putative PBP binding loops; other site 931276005032 ABC-ATPase subunit interface; other site 931276005033 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276005034 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276005035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276005036 dimer interface [polypeptide binding]; other site 931276005037 putative CheW interface [polypeptide binding]; other site 931276005038 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276005039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276005040 active site 931276005041 phosphorylation site [posttranslational modification] 931276005042 intermolecular recognition site; other site 931276005043 dimerization interface [polypeptide binding]; other site 931276005044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276005045 DNA binding site [nucleotide binding] 931276005046 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 931276005047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276005048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276005049 ATP binding site [chemical binding]; other site 931276005050 G-X-G motif; other site 931276005051 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276005052 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276005053 Walker A/P-loop; other site 931276005054 ATP binding site [chemical binding]; other site 931276005055 Q-loop/lid; other site 931276005056 ABC transporter signature motif; other site 931276005057 Walker B; other site 931276005058 D-loop; other site 931276005059 H-loop/switch region; other site 931276005060 purine nucleoside phosphorylase; Provisional; Region: PRK08202 931276005061 PAS fold; Region: PAS_4; pfam08448 931276005062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276005063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276005064 metal binding site [ion binding]; metal-binding site 931276005065 active site 931276005066 I-site; other site 931276005067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276005068 Zn2+ binding site [ion binding]; other site 931276005069 Mg2+ binding site [ion binding]; other site 931276005070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276005071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276005072 putative substrate translocation pore; other site 931276005073 heat shock protein 90; Provisional; Region: PRK05218 931276005074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276005075 ATP binding site [chemical binding]; other site 931276005076 Mg2+ binding site [ion binding]; other site 931276005077 G-X-G motif; other site 931276005078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276005079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276005080 DNA binding residues [nucleotide binding] 931276005081 dimerization interface [polypeptide binding]; other site 931276005082 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276005083 active site turn [active] 931276005084 phosphorylation site [posttranslational modification] 931276005085 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 931276005086 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 931276005087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276005088 FeS/SAM binding site; other site 931276005089 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 931276005090 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 931276005091 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 931276005092 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 931276005093 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 931276005094 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931276005095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276005096 catalytic residue [active] 931276005097 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 931276005098 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931276005099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276005100 catalytic residue [active] 931276005101 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 931276005102 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 931276005103 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 931276005104 Clp amino terminal domain; Region: Clp_N; pfam02861 931276005105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276005106 Walker A motif; other site 931276005107 ATP binding site [chemical binding]; other site 931276005108 Walker B motif; other site 931276005109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276005110 Walker A motif; other site 931276005111 ATP binding site [chemical binding]; other site 931276005112 Walker B motif; other site 931276005113 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 931276005114 Probable zinc-binding domain; Region: zf-trcl; pfam13451 931276005115 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 931276005116 AsnC family; Region: AsnC_trans_reg; pfam01037 931276005117 hypothetical protein; Validated; Region: PRK07682 931276005118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276005119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276005120 homodimer interface [polypeptide binding]; other site 931276005121 catalytic residue [active] 931276005122 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276005123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276005124 DNA binding site [nucleotide binding] 931276005125 domain linker motif; other site 931276005126 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276005127 dimerization interface [polypeptide binding]; other site 931276005128 ligand binding site [chemical binding]; other site 931276005129 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 931276005130 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 931276005131 ligand binding site [chemical binding]; other site 931276005132 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 931276005133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276005134 Walker A/P-loop; other site 931276005135 ATP binding site [chemical binding]; other site 931276005136 Q-loop/lid; other site 931276005137 ABC transporter signature motif; other site 931276005138 Walker B; other site 931276005139 D-loop; other site 931276005140 H-loop/switch region; other site 931276005141 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 931276005142 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276005143 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 931276005144 TM-ABC transporter signature motif; other site 931276005145 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276005146 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 931276005147 TM-ABC transporter signature motif; other site 931276005148 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 931276005149 intersubunit interface [polypeptide binding]; other site 931276005150 active site 931276005151 catalytic residue [active] 931276005152 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 931276005153 active site 931276005154 catalytic motif [active] 931276005155 Zn binding site [ion binding]; other site 931276005156 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 931276005157 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 931276005158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276005159 active site 931276005160 motif I; other site 931276005161 motif II; other site 931276005162 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 931276005163 active site 931276005164 catalytic triad [active] 931276005165 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 931276005166 ArsC family; Region: ArsC; pfam03960 931276005167 catalytic residue [active] 931276005168 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276005169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276005170 Zn2+ binding site [ion binding]; other site 931276005171 Mg2+ binding site [ion binding]; other site 931276005172 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276005173 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276005174 Zn2+ binding site [ion binding]; other site 931276005175 Mg2+ binding site [ion binding]; other site 931276005176 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 931276005177 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 931276005178 active site 931276005179 catalytic site [active] 931276005180 pullulanase, type I; Region: pulA_typeI; TIGR02104 931276005181 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 931276005182 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 931276005183 Ca binding site [ion binding]; other site 931276005184 active site 931276005185 catalytic site [active] 931276005186 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 931276005187 nucleotide binding site/active site [active] 931276005188 HIT family signature motif; other site 931276005189 catalytic residue [active] 931276005190 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 931276005191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276005192 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 931276005193 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 931276005194 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931276005195 inhibitor-cofactor binding pocket; inhibition site 931276005196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276005197 catalytic residue [active] 931276005198 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 931276005199 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276005200 DNA binding residues [nucleotide binding] 931276005201 dimer interface [polypeptide binding]; other site 931276005202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276005203 S-adenosylmethionine binding site [chemical binding]; other site 931276005204 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 931276005205 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931276005206 inhibitor-cofactor binding pocket; inhibition site 931276005207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276005208 catalytic residue [active] 931276005209 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 931276005210 trimer interface [polypeptide binding]; other site 931276005211 active site 931276005212 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 931276005213 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 931276005214 putative RNA binding site [nucleotide binding]; other site 931276005215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276005216 S-adenosylmethionine binding site [chemical binding]; other site 931276005217 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 931276005218 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 931276005219 putative dimer interface [polypeptide binding]; other site 931276005220 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 931276005221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276005222 S-adenosylmethionine binding site [chemical binding]; other site 931276005223 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 931276005224 putative deacylase active site [active] 931276005225 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276005226 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276005227 ligand binding site [chemical binding]; other site 931276005228 calcium binding site [ion binding]; other site 931276005229 3D domain; Region: 3D; cl01439 931276005230 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 931276005231 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 931276005232 ACS interaction site; other site 931276005233 CODH interaction site; other site 931276005234 cubane metal cluster (B-cluster) [ion binding]; other site 931276005235 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 931276005236 amino acid transporter; Region: 2A0306; TIGR00909 931276005237 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 931276005238 amino acid transporter; Region: 2A0306; TIGR00909 931276005239 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 931276005240 Predicted secreted protein [Function unknown]; Region: COG4086 931276005241 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 931276005242 Rrf2 family protein; Region: rrf2_super; TIGR00738 931276005243 Transcriptional regulator; Region: Rrf2; pfam02082 931276005244 Transcriptional regulator; Region: Rrf2; cl17282 931276005245 Heme NO binding; Region: HNOB; pfam07700 931276005246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276005247 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276005248 dimer interface [polypeptide binding]; other site 931276005249 putative CheW interface [polypeptide binding]; other site 931276005250 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 931276005251 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 931276005252 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276005253 DNA binding residues [nucleotide binding] 931276005254 dimerization interface [polypeptide binding]; other site 931276005255 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 931276005256 AAA domain; Region: AAA_31; pfam13614 931276005257 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931276005258 P-loop; other site 931276005259 Magnesium ion binding site [ion binding]; other site 931276005260 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276005261 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 931276005262 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 931276005263 ATP binding site [chemical binding]; other site 931276005264 Walker A motif; other site 931276005265 hexamer interface [polypeptide binding]; other site 931276005266 Walker B motif; other site 931276005267 TadE-like protein; Region: TadE; pfam07811 931276005268 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 931276005269 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931276005270 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 931276005271 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931276005272 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 931276005273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276005274 FeS/SAM binding site; other site 931276005275 CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119 931276005276 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 931276005277 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 931276005278 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 931276005279 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276005280 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276005281 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276005282 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276005283 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 931276005284 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 931276005285 lipoic acid synthase; Region: PLN02428 931276005286 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 931276005287 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 931276005288 MgtE intracellular N domain; Region: MgtE_N; smart00924 931276005289 FOG: CBS domain [General function prediction only]; Region: COG0517 931276005290 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 931276005291 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 931276005292 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 931276005293 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 931276005294 catalytic residues [active] 931276005295 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 931276005296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276005297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276005298 Short C-terminal domain; Region: SHOCT; pfam09851 931276005299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276005300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276005301 active site 931276005302 phosphorylation site [posttranslational modification] 931276005303 intermolecular recognition site; other site 931276005304 dimerization interface [polypeptide binding]; other site 931276005305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276005306 DNA binding site [nucleotide binding] 931276005307 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 931276005308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276005309 dimerization interface [polypeptide binding]; other site 931276005310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276005311 dimer interface [polypeptide binding]; other site 931276005312 phosphorylation site [posttranslational modification] 931276005313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276005314 ATP binding site [chemical binding]; other site 931276005315 Mg2+ binding site [ion binding]; other site 931276005316 G-X-G motif; other site 931276005317 FeoA domain; Region: FeoA; pfam04023 931276005318 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 931276005319 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 931276005320 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 931276005321 G1 box; other site 931276005322 GTP/Mg2+ binding site [chemical binding]; other site 931276005323 Switch I region; other site 931276005324 G2 box; other site 931276005325 G3 box; other site 931276005326 Switch II region; other site 931276005327 G4 box; other site 931276005328 G5 box; other site 931276005329 Nucleoside recognition; Region: Gate; pfam07670 931276005330 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 931276005331 Nucleoside recognition; Region: Gate; pfam07670 931276005332 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276005333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931276005334 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 931276005335 Predicted permeases [General function prediction only]; Region: COG0730 931276005336 putative acyltransferase; Provisional; Region: PRK05790 931276005337 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 931276005338 dimer interface [polypeptide binding]; other site 931276005339 active site 931276005340 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 931276005341 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 931276005342 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 931276005343 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931276005344 catalytic residues [active] 931276005345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276005346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276005347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276005348 dimerization interface [polypeptide binding]; other site 931276005349 hypothetical protein; Validated; Region: PRK07121 931276005350 L-aspartate oxidase; Provisional; Region: PRK06175 931276005351 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 931276005352 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276005353 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276005354 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 931276005355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276005356 Walker A motif; other site 931276005357 ATP binding site [chemical binding]; other site 931276005358 Walker B motif; other site 931276005359 arginine finger; other site 931276005360 Transcriptional antiterminator [Transcription]; Region: COG3933 931276005361 PRD domain; Region: PRD; pfam00874 931276005362 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 931276005363 active pocket/dimerization site; other site 931276005364 active site 931276005365 phosphorylation site [posttranslational modification] 931276005366 PRD domain; Region: PRD; pfam00874 931276005367 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276005368 methionine cluster; other site 931276005369 active site 931276005370 phosphorylation site [posttranslational modification] 931276005371 metal binding site [ion binding]; metal-binding site 931276005372 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276005373 active site 931276005374 P-loop; other site 931276005375 phosphorylation site [posttranslational modification] 931276005376 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276005377 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276005378 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 931276005379 beta-D-glucuronidase; Provisional; Region: PRK10150 931276005380 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 931276005381 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 931276005382 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276005383 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276005384 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276005385 putative active site [active] 931276005386 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276005387 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276005388 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 931276005389 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276005390 beta-galactosidase; Region: BGL; TIGR03356 931276005391 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 931276005392 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 931276005393 Ca binding site [ion binding]; other site 931276005394 active site 931276005395 catalytic site [active] 931276005396 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276005397 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 931276005398 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 931276005399 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276005400 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276005401 active site turn [active] 931276005402 phosphorylation site [posttranslational modification] 931276005403 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 931276005404 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 931276005405 NAD binding site [chemical binding]; other site 931276005406 sugar binding site [chemical binding]; other site 931276005407 divalent metal binding site [ion binding]; other site 931276005408 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276005409 dimer interface [polypeptide binding]; other site 931276005410 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276005411 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276005412 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276005413 putative active site [active] 931276005414 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931276005415 HPr interaction site; other site 931276005416 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276005417 active site 931276005418 phosphorylation site [posttranslational modification] 931276005419 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 931276005420 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 931276005421 putative substrate binding site [chemical binding]; other site 931276005422 putative ATP binding site [chemical binding]; other site 931276005423 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 931276005424 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 931276005425 active site 931276005426 homodimer interface [polypeptide binding]; other site 931276005427 catalytic site [active] 931276005428 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931276005429 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276005430 active site 931276005431 FMN binding site [chemical binding]; other site 931276005432 substrate binding site [chemical binding]; other site 931276005433 putative catalytic residue [active] 931276005434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276005435 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 931276005436 HTH domain; Region: HTH_11; cl17392 931276005437 Mga helix-turn-helix domain; Region: Mga; pfam05043 931276005438 PRD domain; Region: PRD; pfam00874 931276005439 PRD domain; Region: PRD; pfam00874 931276005440 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 931276005441 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931276005442 active site 931276005443 phosphorylation site [posttranslational modification] 931276005444 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276005445 active site 931276005446 P-loop; other site 931276005447 phosphorylation site [posttranslational modification] 931276005448 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276005449 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276005450 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 931276005451 active site 931276005452 methionine cluster; other site 931276005453 phosphorylation site [posttranslational modification] 931276005454 metal binding site [ion binding]; metal-binding site 931276005455 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276005456 beta-galactosidase; Region: BGL; TIGR03356 931276005457 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276005458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276005459 dimerization interface [polypeptide binding]; other site 931276005460 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276005461 dimer interface [polypeptide binding]; other site 931276005462 putative CheW interface [polypeptide binding]; other site 931276005463 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931276005464 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931276005465 dimer interface [polypeptide binding]; other site 931276005466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276005467 catalytic residue [active] 931276005468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276005469 S-adenosylmethionine binding site [chemical binding]; other site 931276005470 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 931276005471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276005472 putative PBP binding loops; other site 931276005473 dimer interface [polypeptide binding]; other site 931276005474 ABC-ATPase subunit interface; other site 931276005475 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276005476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276005477 dimer interface [polypeptide binding]; other site 931276005478 conserved gate region; other site 931276005479 putative PBP binding loops; other site 931276005480 ABC-ATPase subunit interface; other site 931276005481 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276005482 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276005483 Protein of unknown function, DUF624; Region: DUF624; cl02369 931276005484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276005485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276005486 dimerization interface [polypeptide binding]; other site 931276005487 Histidine kinase; Region: His_kinase; pfam06580 931276005488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276005489 ATP binding site [chemical binding]; other site 931276005490 Mg2+ binding site [ion binding]; other site 931276005491 G-X-G motif; other site 931276005492 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 931276005493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276005494 active site 931276005495 phosphorylation site [posttranslational modification] 931276005496 intermolecular recognition site; other site 931276005497 dimerization interface [polypeptide binding]; other site 931276005498 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 931276005499 active site 931276005500 catalytic site [active] 931276005501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276005502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276005503 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 931276005504 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276005505 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276005506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276005507 D-mannonate oxidoreductase; Provisional; Region: PRK08277 931276005508 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 931276005509 putative NAD(P) binding site [chemical binding]; other site 931276005510 active site 931276005511 mannonate dehydratase; Provisional; Region: PRK03906 931276005512 mannonate dehydratase; Region: uxuA; TIGR00695 931276005513 Glucuronate isomerase; Region: UxaC; pfam02614 931276005514 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 931276005515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276005516 dimerization interface [polypeptide binding]; other site 931276005517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276005518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276005519 dimer interface [polypeptide binding]; other site 931276005520 phosphorylation site [posttranslational modification] 931276005521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276005522 ATP binding site [chemical binding]; other site 931276005523 Mg2+ binding site [ion binding]; other site 931276005524 G-X-G motif; other site 931276005525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276005527 active site 931276005528 phosphorylation site [posttranslational modification] 931276005529 intermolecular recognition site; other site 931276005530 dimerization interface [polypeptide binding]; other site 931276005531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276005532 DNA binding site [nucleotide binding] 931276005533 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 931276005534 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 931276005535 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 931276005536 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 931276005537 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931276005538 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276005539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276005540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276005541 Walker A/P-loop; other site 931276005542 ATP binding site [chemical binding]; other site 931276005543 Q-loop/lid; other site 931276005544 ABC transporter signature motif; other site 931276005545 Walker B; other site 931276005546 D-loop; other site 931276005547 H-loop/switch region; other site 931276005548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276005549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276005550 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931276005551 Walker A/P-loop; other site 931276005552 ATP binding site [chemical binding]; other site 931276005553 Q-loop/lid; other site 931276005554 ABC transporter signature motif; other site 931276005555 Walker B; other site 931276005556 D-loop; other site 931276005557 H-loop/switch region; other site 931276005558 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276005559 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 931276005560 putative active site [active] 931276005561 putative metal binding site [ion binding]; other site 931276005562 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 931276005563 active site 931276005564 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 931276005565 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276005566 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276005567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276005568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276005569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276005570 dimerization interface [polypeptide binding]; other site 931276005571 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276005572 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931276005573 DNA binding residues [nucleotide binding] 931276005574 putative dimer interface [polypeptide binding]; other site 931276005575 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276005576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276005577 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 931276005578 active site 1 [active] 931276005579 dimer interface [polypeptide binding]; other site 931276005580 hexamer interface [polypeptide binding]; other site 931276005581 active site 2 [active] 931276005582 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276005583 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931276005584 active site 931276005585 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276005586 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 931276005587 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 931276005588 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 931276005589 TPP-binding site; other site 931276005590 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276005591 PYR/PP interface [polypeptide binding]; other site 931276005592 dimer interface [polypeptide binding]; other site 931276005593 TPP binding site [chemical binding]; other site 931276005594 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276005595 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 931276005596 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 931276005597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931276005598 catalytic core [active] 931276005599 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276005600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931276005601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 931276005602 active site 931276005603 catalytic tetrad [active] 931276005604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 931276005605 sequence-specific DNA binding site [nucleotide binding]; other site 931276005606 salt bridge; other site 931276005607 Helix-turn-helix domain; Region: HTH_17; cl17695 931276005608 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 931276005609 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 931276005610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276005611 Walker A motif; other site 931276005612 ATP binding site [chemical binding]; other site 931276005613 Walker B motif; other site 931276005614 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 931276005615 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276005616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276005617 Coenzyme A binding pocket [chemical binding]; other site 931276005618 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276005619 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276005620 4Fe-4S binding domain; Region: Fer4; pfam00037 931276005621 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276005622 Isochorismatase family; Region: Isochorismatase; pfam00857 931276005623 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 931276005624 catalytic triad [active] 931276005625 conserved cis-peptide bond; other site 931276005626 Rrf2 family protein; Region: rrf2_super; TIGR00738 931276005627 Transcriptional regulator; Region: Rrf2; pfam02082 931276005628 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 931276005629 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 931276005630 catalytic residues [active] 931276005631 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 931276005632 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 931276005633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276005634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276005635 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 931276005636 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276005637 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 931276005638 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 931276005639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276005640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276005641 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931276005642 active site 931276005643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276005644 Coenzyme A binding pocket [chemical binding]; other site 931276005645 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 931276005646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276005647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276005648 metal binding site [ion binding]; metal-binding site 931276005649 active site 931276005650 I-site; other site 931276005651 YvrJ protein family; Region: YvrJ; pfam12841 931276005652 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 931276005653 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 931276005654 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276005655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276005656 S-adenosylmethionine binding site [chemical binding]; other site 931276005657 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 931276005658 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 931276005659 dimer interface [polypeptide binding]; other site 931276005660 active site 931276005661 CoA binding pocket [chemical binding]; other site 931276005662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276005663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276005664 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 931276005665 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276005666 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276005667 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276005668 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276005669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276005670 Walker A/P-loop; other site 931276005671 ATP binding site [chemical binding]; other site 931276005672 Q-loop/lid; other site 931276005673 ABC transporter signature motif; other site 931276005674 Walker B; other site 931276005675 D-loop; other site 931276005676 H-loop/switch region; other site 931276005677 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931276005678 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 931276005679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276005680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276005681 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276005682 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276005683 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276005684 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276005685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276005686 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 931276005687 putative substrate translocation pore; other site 931276005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276005689 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 931276005690 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 931276005691 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 931276005692 active site 931276005693 HIGH motif; other site 931276005694 KMSKS motif; other site 931276005695 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 931276005696 tRNA binding surface [nucleotide binding]; other site 931276005697 anticodon binding site; other site 931276005698 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 931276005699 Patatin-like phospholipase; Region: Patatin; pfam01734 931276005700 active site 931276005701 nucleophile elbow; other site 931276005702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276005703 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 931276005704 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276005705 DNA binding residues [nucleotide binding] 931276005706 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276005707 MarR family; Region: MarR_2; pfam12802 931276005708 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276005709 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 931276005710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276005711 dimerization interface [polypeptide binding]; other site 931276005712 putative DNA binding site [nucleotide binding]; other site 931276005713 putative Zn2+ binding site [ion binding]; other site 931276005714 MarR family; Region: MarR_2; pfam12802 931276005715 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276005716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276005717 Coenzyme A binding pocket [chemical binding]; other site 931276005718 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276005719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276005720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276005721 Walker A/P-loop; other site 931276005722 ATP binding site [chemical binding]; other site 931276005723 Q-loop/lid; other site 931276005724 ABC transporter signature motif; other site 931276005725 Walker B; other site 931276005726 D-loop; other site 931276005727 H-loop/switch region; other site 931276005728 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 931276005729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276005730 FeS/SAM binding site; other site 931276005731 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 931276005732 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 931276005733 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 931276005734 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 931276005735 Asp-box motif; other site 931276005736 Cellulose binding domain; Region: CBM_3; pfam00942 931276005737 Cellulose binding domain; Region: CBM_3; pfam00942 931276005738 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 931276005739 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 931276005740 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 931276005741 dockerin binding interface; other site 931276005742 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 931276005743 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 931276005744 dockerin binding interface; other site 931276005745 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 931276005746 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 931276005747 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 931276005748 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 931276005749 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 931276005750 endoglucanase; Region: PLN02420 931276005751 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 931276005752 Cellulose binding domain; Region: CBM_3; pfam00942 931276005753 Dockerin type I repeat; Region: Dockerin_1; pfam00404 931276005754 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 931276005755 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 931276005756 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 931276005757 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931276005758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276005759 active site 931276005760 phosphorylation site [posttranslational modification] 931276005761 intermolecular recognition site; other site 931276005762 dimerization interface [polypeptide binding]; other site 931276005763 LytTr DNA-binding domain; Region: LytTR; pfam04397 931276005764 Accessory gene regulator B; Region: AgrB; cl01873 931276005765 CAAX protease self-immunity; Region: Abi; pfam02517 931276005766 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 931276005767 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 931276005768 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 931276005769 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 931276005770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276005771 putative substrate translocation pore; other site 931276005772 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276005773 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276005774 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276005775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276005776 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276005777 putative substrate translocation pore; other site 931276005778 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 931276005779 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 931276005780 G1 box; other site 931276005781 putative GEF interaction site [polypeptide binding]; other site 931276005782 GTP/Mg2+ binding site [chemical binding]; other site 931276005783 Switch I region; other site 931276005784 G2 box; other site 931276005785 G3 box; other site 931276005786 Switch II region; other site 931276005787 G4 box; other site 931276005788 G5 box; other site 931276005789 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 931276005790 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 931276005791 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 931276005792 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 931276005793 active site 931276005794 catalytic triad [active] 931276005795 oxyanion hole [active] 931276005796 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 931276005797 Predicted membrane protein [Function unknown]; Region: COG2323 931276005798 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276005799 HAMP domain; Region: HAMP; pfam00672 931276005800 dimerization interface [polypeptide binding]; other site 931276005801 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276005802 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276005803 dimer interface [polypeptide binding]; other site 931276005804 putative CheW interface [polypeptide binding]; other site 931276005805 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 931276005806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276005807 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 931276005808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276005809 Coenzyme A binding pocket [chemical binding]; other site 931276005810 VanZ like family; Region: VanZ; pfam04892 931276005811 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 931276005812 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 931276005813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276005814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276005815 dimerization interface [polypeptide binding]; other site 931276005816 putative DNA binding site [nucleotide binding]; other site 931276005817 putative Zn2+ binding site [ion binding]; other site 931276005818 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 931276005819 Low molecular weight phosphatase family; Region: LMWPc; cd00115 931276005820 active site 931276005821 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 931276005822 arsenical-resistance protein; Region: acr3; TIGR00832 931276005823 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 931276005824 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 931276005825 tetramer interface [polypeptide binding]; other site 931276005826 active site 931276005827 Mg2+/Mn2+ binding site [ion binding]; other site 931276005828 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 931276005829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276005830 Coenzyme A binding pocket [chemical binding]; other site 931276005831 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276005832 MarR family; Region: MarR; pfam01047 931276005833 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276005834 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 931276005835 Interdomain contacts; other site 931276005836 Cytokine receptor motif; other site 931276005837 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276005838 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276005839 Domain of unknown function DUF11; Region: DUF11; cl17728 931276005840 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276005841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276005842 dimerization interface [polypeptide binding]; other site 931276005843 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276005844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276005845 dimer interface [polypeptide binding]; other site 931276005846 putative CheW interface [polypeptide binding]; other site 931276005847 Predicted membrane protein [Function unknown]; Region: COG2510 931276005848 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 931276005849 active site 931276005850 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 931276005851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276005852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276005853 active site 931276005854 phosphorylation site [posttranslational modification] 931276005855 intermolecular recognition site; other site 931276005856 dimerization interface [polypeptide binding]; other site 931276005857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276005858 DNA binding site [nucleotide binding] 931276005859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276005860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276005861 dimer interface [polypeptide binding]; other site 931276005862 phosphorylation site [posttranslational modification] 931276005863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276005864 ATP binding site [chemical binding]; other site 931276005865 Mg2+ binding site [ion binding]; other site 931276005866 G-X-G motif; other site 931276005867 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 931276005868 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 931276005869 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 931276005870 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 931276005871 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 931276005872 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 931276005873 active site 931276005874 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276005875 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 931276005876 putative ADP-binding pocket [chemical binding]; other site 931276005877 Zn binding site [ion binding]; other site 931276005878 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 931276005879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276005880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276005881 dimerization interface [polypeptide binding]; other site 931276005882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276005883 dimer interface [polypeptide binding]; other site 931276005884 phosphorylation site [posttranslational modification] 931276005885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276005886 ATP binding site [chemical binding]; other site 931276005887 Mg2+ binding site [ion binding]; other site 931276005888 G-X-G motif; other site 931276005889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276005890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276005891 active site 931276005892 phosphorylation site [posttranslational modification] 931276005893 intermolecular recognition site; other site 931276005894 dimerization interface [polypeptide binding]; other site 931276005895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276005896 DNA binding site [nucleotide binding] 931276005897 Uncharacterized conserved protein [Function unknown]; Region: COG0398 931276005898 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 931276005899 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 931276005900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276005901 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 931276005902 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 931276005903 active site 931276005904 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276005905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276005906 substrate binding pocket [chemical binding]; other site 931276005907 membrane-bound complex binding site; other site 931276005908 hinge residues; other site 931276005909 hybrid cluster protein; Provisional; Region: PRK05290 931276005910 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276005911 ACS interaction site; other site 931276005912 CODH interaction site; other site 931276005913 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276005914 ACS interaction site; other site 931276005915 CODH interaction site; other site 931276005916 metal cluster binding site [ion binding]; other site 931276005917 PgaD-like protein; Region: PgaD; cl14676 931276005918 N-glycosyltransferase; Provisional; Region: PRK11204 931276005919 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 931276005920 DXD motif; other site 931276005921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276005922 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 931276005923 active site 931276005924 metal binding site [ion binding]; metal-binding site 931276005925 Resolvase, N terminal domain; Region: Resolvase; pfam00239 931276005926 catalytic residues [active] 931276005927 catalytic nucleophile [active] 931276005928 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 931276005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276005930 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 931276005931 hypothetical protein; Validated; Region: PRK07080 931276005932 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 931276005933 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 931276005934 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 931276005935 homotrimer interaction site [polypeptide binding]; other site 931276005936 putative active site [active] 931276005937 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 931276005938 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 931276005939 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 931276005940 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 931276005941 Walker A/P-loop; other site 931276005942 ATP binding site [chemical binding]; other site 931276005943 Q-loop/lid; other site 931276005944 ABC transporter signature motif; other site 931276005945 Walker B; other site 931276005946 D-loop; other site 931276005947 H-loop/switch region; other site 931276005948 NIL domain; Region: NIL; pfam09383 931276005949 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 931276005950 FAD binding domain; Region: FAD_binding_4; pfam01565 931276005951 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 931276005952 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276005953 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276005954 Domain of unknown function DUF11; Region: DUF11; cl17728 931276005955 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276005956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276005957 substrate binding pocket [chemical binding]; other site 931276005958 membrane-bound complex binding site; other site 931276005959 hinge residues; other site 931276005960 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 931276005961 putative homodimer interface [polypeptide binding]; other site 931276005962 putative homotetramer interface [polypeptide binding]; other site 931276005963 putative metal binding site [ion binding]; other site 931276005964 putative homodimer-homodimer interface [polypeptide binding]; other site 931276005965 putative allosteric switch controlling residues; other site 931276005966 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276005967 EamA-like transporter family; Region: EamA; pfam00892 931276005968 EamA-like transporter family; Region: EamA; pfam00892 931276005969 Domain of unknown function DUF11; Region: DUF11; cl17728 931276005970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276005971 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276005972 Coenzyme A binding pocket [chemical binding]; other site 931276005973 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 931276005974 putative hydrophobic ligand binding site [chemical binding]; other site 931276005975 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 931276005976 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 931276005977 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 931276005978 conserved cys residue [active] 931276005979 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 931276005980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276005981 motif II; other site 931276005982 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931276005983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276005984 ligand binding site [chemical binding]; other site 931276005985 flexible hinge region; other site 931276005986 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 931276005987 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 931276005988 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931276005989 inhibitor-cofactor binding pocket; inhibition site 931276005990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276005991 catalytic residue [active] 931276005992 WxcM-like, C-terminal; Region: FdtA; pfam05523 931276005993 Protein of unknown function (DUF563); Region: DUF563; pfam04577 931276005994 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 931276005995 putative trimer interface [polypeptide binding]; other site 931276005996 putative CoA binding site [chemical binding]; other site 931276005997 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 931276005998 putative trimer interface [polypeptide binding]; other site 931276005999 putative active site [active] 931276006000 putative substrate binding site [chemical binding]; other site 931276006001 putative CoA binding site [chemical binding]; other site 931276006002 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 931276006003 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276006004 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931276006005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276006006 active site 931276006007 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 931276006008 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 931276006009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276006010 catalytic residue [active] 931276006011 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 931276006012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276006013 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276006014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276006015 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 931276006016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276006017 NAD(P) binding site [chemical binding]; other site 931276006018 active site 931276006019 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 931276006020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276006021 NAD(P) binding site [chemical binding]; other site 931276006022 active site 931276006023 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 931276006024 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931276006025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276006026 FeS/SAM binding site; other site 931276006027 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 931276006028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276006029 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 931276006030 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 931276006031 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 931276006032 putative metal binding site; other site 931276006033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931276006034 binding surface 931276006035 TPR motif; other site 931276006036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276006037 TPR motif; other site 931276006038 binding surface 931276006039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276006040 binding surface 931276006041 TPR motif; other site 931276006042 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 931276006043 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931276006044 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 931276006045 putative metal binding site; other site 931276006046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276006047 binding surface 931276006048 TPR motif; other site 931276006049 TPR repeat; Region: TPR_11; pfam13414 931276006050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276006051 binding surface 931276006052 TPR motif; other site 931276006053 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 931276006054 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 931276006055 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931276006056 Probable Catalytic site; other site 931276006057 metal-binding site 931276006058 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276006059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276006060 S-adenosylmethionine binding site [chemical binding]; other site 931276006061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276006062 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276006063 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 931276006064 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 931276006065 Uncharacterized conserved protein [Function unknown]; Region: COG3391 931276006066 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 931276006067 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 931276006068 substrate binding site; other site 931276006069 tetramer interface; other site 931276006070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006071 dimer interface [polypeptide binding]; other site 931276006072 putative CheW interface [polypeptide binding]; other site 931276006073 PAS domain S-box; Region: sensory_box; TIGR00229 931276006074 PAS domain S-box; Region: sensory_box; TIGR00229 931276006075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276006076 PAS fold; Region: PAS_3; pfam08447 931276006077 putative active site [active] 931276006078 heme pocket [chemical binding]; other site 931276006079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276006080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276006081 dimer interface [polypeptide binding]; other site 931276006082 phosphorylation site [posttranslational modification] 931276006083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276006084 ATP binding site [chemical binding]; other site 931276006085 Mg2+ binding site [ion binding]; other site 931276006086 G-X-G motif; other site 931276006087 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276006088 HAMP domain; Region: HAMP; pfam00672 931276006089 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276006090 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006091 dimer interface [polypeptide binding]; other site 931276006092 putative CheW interface [polypeptide binding]; other site 931276006093 Predicted transcriptional regulator [Transcription]; Region: COG2378 931276006094 HTH domain; Region: HTH_11; pfam08279 931276006095 WYL domain; Region: WYL; pfam13280 931276006096 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 931276006097 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276006098 MarR family; Region: MarR_2; pfam12802 931276006099 short chain dehydrogenase; Provisional; Region: PRK06197 931276006100 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 931276006101 putative NAD(P) binding site [chemical binding]; other site 931276006102 active site 931276006103 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276006104 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931276006105 DNA binding residues [nucleotide binding] 931276006106 drug binding residues [chemical binding]; other site 931276006107 dimer interface [polypeptide binding]; other site 931276006108 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276006109 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 931276006110 RNA polymerase factor sigma-70; Validated; Region: PRK06811 931276006111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276006112 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 931276006113 DNA binding residues [nucleotide binding] 931276006114 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 931276006115 Helix-turn-helix domain; Region: HTH_17; pfam12728 931276006116 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 931276006117 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276006118 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276006119 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 931276006120 Fn3 associated; Region: Fn3_assoc; pfam13287 931276006121 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 931276006122 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 931276006123 Fn3 associated; Region: Fn3_assoc; pfam13287 931276006124 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 931276006125 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276006126 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276006127 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276006128 YCII-related domain; Region: YCII; cl00999 931276006129 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 931276006130 Walker A/P-loop; other site 931276006131 ATP binding site [chemical binding]; other site 931276006132 Q-loop/lid; other site 931276006133 ABC transporter signature motif; other site 931276006134 Walker B; other site 931276006135 D-loop; other site 931276006136 H-loop/switch region; other site 931276006137 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276006138 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931276006139 FeS/SAM binding site; other site 931276006140 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276006141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276006142 substrate binding pocket [chemical binding]; other site 931276006143 membrane-bound complex binding site; other site 931276006144 hinge residues; other site 931276006145 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276006146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276006147 S-adenosylmethionine binding site [chemical binding]; other site 931276006148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931276006149 classical (c) SDRs; Region: SDR_c; cd05233 931276006150 NAD(P) binding site [chemical binding]; other site 931276006151 active site 931276006152 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 931276006153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276006154 Zn2+ binding site [ion binding]; other site 931276006155 Mg2+ binding site [ion binding]; other site 931276006156 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 931276006157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006158 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276006159 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276006160 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276006161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276006162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276006163 putative substrate translocation pore; other site 931276006164 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 931276006165 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276006166 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276006167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006169 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 931276006170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 931276006171 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 931276006172 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 931276006173 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 931276006174 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 931276006175 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 931276006176 putative NAD(P) binding site [chemical binding]; other site 931276006177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006179 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 931276006180 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276006181 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276006182 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 931276006183 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 931276006184 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276006185 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 931276006186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006187 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276006188 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 931276006189 glycosyltransferase, MGT family; Region: MGT; TIGR01426 931276006190 active site 931276006191 TDP-binding site; other site 931276006192 acceptor substrate-binding pocket; other site 931276006193 homodimer interface [polypeptide binding]; other site 931276006194 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276006195 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276006196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006200 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 931276006201 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 931276006202 NADP binding site [chemical binding]; other site 931276006203 putative substrate binding site [chemical binding]; other site 931276006204 active site 931276006205 oxidoreductase; Provisional; Region: PRK06196 931276006206 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 931276006207 putative NAD(P) binding site [chemical binding]; other site 931276006208 active site 931276006209 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931276006210 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276006211 DNA binding residues [nucleotide binding] 931276006212 putative dimer interface [polypeptide binding]; other site 931276006213 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276006214 MarR family; Region: MarR; pfam01047 931276006215 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 931276006216 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 931276006217 active site 931276006218 substrate binding site [chemical binding]; other site 931276006219 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 931276006220 FMN binding site [chemical binding]; other site 931276006221 putative catalytic residues [active] 931276006222 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276006223 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276006224 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276006225 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276006226 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 931276006227 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276006228 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276006229 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 931276006230 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 931276006231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276006232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276006233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276006234 dimerization interface [polypeptide binding]; other site 931276006235 putative acyltransferase; Provisional; Region: PRK05790 931276006236 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 931276006237 dimer interface [polypeptide binding]; other site 931276006238 active site 931276006239 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 931276006240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006242 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931276006243 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276006244 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 931276006245 putative FMN binding site [chemical binding]; other site 931276006246 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276006247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276006248 Coenzyme A binding pocket [chemical binding]; other site 931276006249 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 931276006250 transmembrane helices; other site 931276006251 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 931276006252 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276006253 MarR family; Region: MarR; pfam01047 931276006254 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276006255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006256 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931276006257 Beta-lactamase; Region: Beta-lactamase; pfam00144 931276006258 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931276006259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276006260 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276006261 active site 931276006262 motif I; other site 931276006263 motif II; other site 931276006264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276006265 motif II; other site 931276006266 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276006267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931276006269 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931276006270 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276006271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276006272 Walker A/P-loop; other site 931276006273 ATP binding site [chemical binding]; other site 931276006274 Q-loop/lid; other site 931276006275 ABC transporter signature motif; other site 931276006276 Walker B; other site 931276006277 D-loop; other site 931276006278 H-loop/switch region; other site 931276006279 ABC-2 type transporter; Region: ABC2_membrane; cl17235 931276006280 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276006281 MarR family; Region: MarR_2; pfam12802 931276006282 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 931276006283 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276006284 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276006285 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 931276006286 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931276006287 Sensory domain found in PocR; Region: PocR; pfam10114 931276006288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006289 dimer interface [polypeptide binding]; other site 931276006290 putative CheW interface [polypeptide binding]; other site 931276006291 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 931276006292 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276006293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276006294 dimerization interface [polypeptide binding]; other site 931276006295 putative DNA binding site [nucleotide binding]; other site 931276006296 putative Zn2+ binding site [ion binding]; other site 931276006297 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 931276006298 putative ADP-ribose binding site [chemical binding]; other site 931276006299 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 931276006300 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 931276006301 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931276006302 EamA-like transporter family; Region: EamA; pfam00892 931276006303 Cupin domain; Region: Cupin_2; pfam07883 931276006304 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276006305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006306 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 931276006307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276006308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276006309 putative substrate translocation pore; other site 931276006310 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 931276006311 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276006312 ligand binding site [chemical binding]; other site 931276006313 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276006314 calcium binding site [ion binding]; other site 931276006315 Uncharacterized conserved protein [Function unknown]; Region: COG3603 931276006316 Family description; Region: ACT_7; pfam13840 931276006317 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 931276006318 active site 931276006319 DNA binding site [nucleotide binding] 931276006320 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 931276006321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276006322 putative active site [active] 931276006323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276006324 putative active site [active] 931276006325 heme pocket [chemical binding]; other site 931276006326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276006327 Walker A motif; other site 931276006328 ATP binding site [chemical binding]; other site 931276006329 Walker B motif; other site 931276006330 arginine finger; other site 931276006331 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276006332 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 931276006333 Coenzyme A transferase; Region: CoA_trans; smart00882 931276006334 Coenzyme A transferase; Region: CoA_trans; cl17247 931276006335 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 931276006336 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 931276006337 dimer interaction site [polypeptide binding]; other site 931276006338 substrate-binding tunnel; other site 931276006339 active site 931276006340 catalytic site [active] 931276006341 substrate binding site [chemical binding]; other site 931276006342 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 931276006343 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 931276006344 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 931276006345 putative acyltransferase; Provisional; Region: PRK05790 931276006346 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 931276006347 dimer interface [polypeptide binding]; other site 931276006348 active site 931276006349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 931276006350 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 931276006351 FAD binding site [chemical binding]; other site 931276006352 homotetramer interface [polypeptide binding]; other site 931276006353 substrate binding pocket [chemical binding]; other site 931276006354 catalytic base [active] 931276006355 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 931276006356 Ligand binding site [chemical binding]; other site 931276006357 Electron transfer flavoprotein domain; Region: ETF; pfam01012 931276006358 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931276006359 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 931276006360 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931276006361 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 931276006362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276006363 dimerization interface [polypeptide binding]; other site 931276006364 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276006365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006366 dimer interface [polypeptide binding]; other site 931276006367 putative CheW interface [polypeptide binding]; other site 931276006368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006370 phosphoenolpyruvate synthase; Validated; Region: PRK06241 931276006371 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 931276006372 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 931276006373 Predicted transcriptional regulators [Transcription]; Region: COG1378 931276006374 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 931276006375 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 931276006376 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 931276006377 Putative transposase; Region: Y2_Tnp; pfam04986 931276006378 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 931276006379 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276006380 active site 931276006381 DNA binding site [nucleotide binding] 931276006382 Int/Topo IB signature motif; other site 931276006383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006385 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 931276006386 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 931276006387 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931276006388 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931276006389 putative active site [active] 931276006390 putative NTP binding site [chemical binding]; other site 931276006391 putative nucleic acid binding site [nucleotide binding]; other site 931276006392 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931276006393 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276006394 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276006395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276006396 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 931276006397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276006398 FeS/SAM binding site; other site 931276006399 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 931276006400 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 931276006401 substrate binding site [chemical binding]; other site 931276006402 active site 931276006403 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 931276006404 metal binding site [ion binding]; metal-binding site 931276006405 ligand binding site [chemical binding]; other site 931276006406 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 931276006407 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 931276006408 P-loop; other site 931276006409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276006410 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 931276006411 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 931276006412 ACS interaction site; other site 931276006413 CODH interaction site; other site 931276006414 cubane metal cluster (B-cluster) [ion binding]; other site 931276006415 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 931276006416 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 931276006417 4Fe-4S binding domain; Region: Fer4; pfam00037 931276006418 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 931276006419 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 931276006420 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 931276006421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276006422 Walker A motif; other site 931276006423 ATP binding site [chemical binding]; other site 931276006424 Walker B motif; other site 931276006425 arginine finger; other site 931276006426 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276006427 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276006428 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276006429 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276006430 putative active site [active] 931276006431 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276006432 methionine cluster; other site 931276006433 active site 931276006434 phosphorylation site [posttranslational modification] 931276006435 metal binding site [ion binding]; metal-binding site 931276006436 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 931276006437 HPr interaction site; other site 931276006438 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276006439 active site 931276006440 phosphorylation site [posttranslational modification] 931276006441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 931276006442 active site 931276006443 motif I; other site 931276006444 motif II; other site 931276006445 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 931276006446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276006447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276006448 putative Zn2+ binding site [ion binding]; other site 931276006449 putative DNA binding site [nucleotide binding]; other site 931276006450 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 931276006451 short chain dehydrogenase; Provisional; Region: PRK05993 931276006452 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 931276006453 NADP binding site [chemical binding]; other site 931276006454 active site 931276006455 steroid binding site; other site 931276006456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006458 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 931276006459 Flavodoxin domain; Region: Flavodoxin_5; cl17428 931276006460 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276006461 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276006462 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931276006463 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 931276006464 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931276006465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276006466 ABC-ATPase subunit interface; other site 931276006467 putative PBP binding loops; other site 931276006468 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 931276006469 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 931276006470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276006471 dimer interface [polypeptide binding]; other site 931276006472 conserved gate region; other site 931276006473 putative PBP binding loops; other site 931276006474 ABC-ATPase subunit interface; other site 931276006475 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931276006476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276006477 Walker A/P-loop; other site 931276006478 ATP binding site [chemical binding]; other site 931276006479 Q-loop/lid; other site 931276006480 ABC transporter signature motif; other site 931276006481 Walker B; other site 931276006482 D-loop; other site 931276006483 H-loop/switch region; other site 931276006484 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276006485 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 931276006486 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276006487 Walker A/P-loop; other site 931276006488 ATP binding site [chemical binding]; other site 931276006489 Q-loop/lid; other site 931276006490 ABC transporter signature motif; other site 931276006491 Walker B; other site 931276006492 D-loop; other site 931276006493 H-loop/switch region; other site 931276006494 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276006495 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 931276006496 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 931276006497 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276006498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276006499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276006500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931276006501 dimerization interface [polypeptide binding]; other site 931276006502 Amidohydrolase; Region: Amidohydro_2; pfam04909 931276006503 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276006504 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276006505 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276006506 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931276006507 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276006508 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276006509 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276006510 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276006511 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276006512 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 931276006513 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 931276006514 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 931276006515 endoglucanase; Region: PLN02420 931276006516 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 931276006517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276006518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276006519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276006520 dimerization interface [polypeptide binding]; other site 931276006521 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 931276006522 Flavoprotein; Region: Flavoprotein; pfam02441 931276006523 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 931276006524 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 931276006525 NAD(P) binding site [chemical binding]; other site 931276006526 catalytic residues [active] 931276006527 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 931276006528 butyrate kinase; Provisional; Region: PRK03011 931276006529 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 931276006530 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 931276006531 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 931276006532 active site 931276006533 P-loop; other site 931276006534 phosphorylation site [posttranslational modification] 931276006535 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276006536 active site 931276006537 metal binding site [ion binding]; metal-binding site 931276006538 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 931276006539 PRD domain; Region: PRD; pfam00874 931276006540 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 931276006541 active site 931276006542 P-loop; other site 931276006543 phosphorylation site [posttranslational modification] 931276006544 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 931276006545 active site 931276006546 phosphorylation site [posttranslational modification] 931276006547 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931276006548 active site 931276006549 phosphorylation site [posttranslational modification] 931276006550 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 931276006551 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 931276006552 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 931276006553 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 931276006554 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 931276006555 glutaminase active site [active] 931276006556 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 931276006557 dimer interface [polypeptide binding]; other site 931276006558 active site 931276006559 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 931276006560 dimer interface [polypeptide binding]; other site 931276006561 active site 931276006562 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 931276006563 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 931276006564 NAD(P) binding site [chemical binding]; other site 931276006565 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 931276006566 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 931276006567 active site 931276006568 catalytic site [active] 931276006569 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276006570 RibD C-terminal domain; Region: RibD_C; cl17279 931276006571 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 931276006572 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 931276006573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276006574 motif II; other site 931276006575 amidophosphoribosyltransferase; Provisional; Region: PRK05793 931276006576 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 931276006577 active site 931276006578 tetramer interface [polypeptide binding]; other site 931276006579 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276006580 active site 931276006581 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276006582 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 931276006583 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 931276006584 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 931276006585 GGGtGRT protein; Region: GGGtGRT; pfam14057 931276006586 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276006587 active site 931276006588 Int/Topo IB signature motif; other site 931276006589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276006590 non-specific DNA binding site [nucleotide binding]; other site 931276006591 salt bridge; other site 931276006592 sequence-specific DNA binding site [nucleotide binding]; other site 931276006593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276006594 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 931276006595 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 931276006596 Protein of unknown function (DUF429); Region: DUF429; pfam04250 931276006597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276006598 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 931276006599 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276006600 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 931276006601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276006603 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 931276006604 active site 931276006605 Mor transcription activator family; Region: Mor; cl02360 931276006606 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276006607 MarR family; Region: MarR; pfam01047 931276006608 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 931276006609 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 931276006610 putative active site [active] 931276006611 putative metal binding site [ion binding]; other site 931276006612 Hemerythrin; Region: Hemerythrin; cd12107 931276006613 Fe binding site [ion binding]; other site 931276006614 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276006615 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 931276006616 Hemerythrin; Region: Hemerythrin; cd12107 931276006617 Fe binding site [ion binding]; other site 931276006618 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 931276006619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276006620 Walker A motif; other site 931276006621 ATP binding site [chemical binding]; other site 931276006622 Walker B motif; other site 931276006623 arginine finger; other site 931276006624 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276006625 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 931276006626 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 931276006627 putative NAD(P) binding site [chemical binding]; other site 931276006628 catalytic Zn binding site [ion binding]; other site 931276006629 Condensation domain; Region: Condensation; pfam00668 931276006630 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276006631 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 931276006632 acyl-activating enzyme (AAE) consensus motif; other site 931276006633 AMP binding site [chemical binding]; other site 931276006634 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276006635 Condensation domain; Region: Condensation; pfam00668 931276006636 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276006637 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 931276006638 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 931276006639 acyl-activating enzyme (AAE) consensus motif; other site 931276006640 AMP binding site [chemical binding]; other site 931276006641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276006642 thioester reductase domain; Region: Thioester-redct; TIGR01746 931276006643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276006644 NAD(P) binding site [chemical binding]; other site 931276006645 active site 931276006646 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276006647 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276006648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276006649 dimerization interface [polypeptide binding]; other site 931276006650 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006652 dimer interface [polypeptide binding]; other site 931276006653 putative CheW interface [polypeptide binding]; other site 931276006654 EamA-like transporter family; Region: EamA; pfam00892 931276006655 EamA-like transporter family; Region: EamA; pfam00892 931276006656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276006657 putative transporter; Provisional; Region: PRK10504 931276006658 putative substrate translocation pore; other site 931276006659 MarR family; Region: MarR_2; cl17246 931276006660 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276006661 Isochorismatase family; Region: Isochorismatase; pfam00857 931276006662 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 931276006663 catalytic triad [active] 931276006664 conserved cis-peptide bond; other site 931276006665 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 931276006666 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 931276006667 AsnC family; Region: AsnC_trans_reg; pfam01037 931276006668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276006669 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276006670 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276006671 putative membrane fusion protein; Region: TIGR02828 931276006672 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 931276006673 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931276006674 MarR family; Region: MarR; pfam01047 931276006675 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 931276006676 hydrophobic ligand binding site; other site 931276006677 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 931276006678 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276006679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276006681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006682 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 931276006683 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 931276006684 EamA-like transporter family; Region: EamA; cl17759 931276006685 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276006686 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276006687 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 931276006688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276006689 dimer interface [polypeptide binding]; other site 931276006690 conserved gate region; other site 931276006691 putative PBP binding loops; other site 931276006692 ABC-ATPase subunit interface; other site 931276006693 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276006694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276006695 dimer interface [polypeptide binding]; other site 931276006696 conserved gate region; other site 931276006697 putative PBP binding loops; other site 931276006698 ABC-ATPase subunit interface; other site 931276006699 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 931276006700 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 931276006701 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 931276006702 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 931276006703 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 931276006704 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276006705 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276006706 Metal-binding active site; metal-binding site 931276006707 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 931276006708 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276006709 active site turn [active] 931276006710 phosphorylation site [posttranslational modification] 931276006711 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276006712 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931276006713 HPr interaction site; other site 931276006714 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276006715 active site 931276006716 phosphorylation site [posttranslational modification] 931276006717 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276006718 beta-galactosidase; Region: BGL; TIGR03356 931276006719 transcriptional antiterminator BglG; Provisional; Region: PRK09772 931276006720 CAT RNA binding domain; Region: CAT_RBD; smart01061 931276006721 PRD domain; Region: PRD; pfam00874 931276006722 PRD domain; Region: PRD; pfam00874 931276006723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 931276006724 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 931276006725 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 931276006726 Transcriptional regulator [Transcription]; Region: IclR; COG1414 931276006727 Bacterial transcriptional regulator; Region: IclR; pfam01614 931276006728 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 931276006729 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 931276006730 inhibitor site; inhibition site 931276006731 active site 931276006732 dimer interface [polypeptide binding]; other site 931276006733 catalytic residue [active] 931276006734 Dehydratase family; Region: ILVD_EDD; pfam00920 931276006735 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 931276006736 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 931276006737 inhibitor binding site; inhibition site 931276006738 active site 931276006739 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276006740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276006741 putative substrate translocation pore; other site 931276006742 hypothetical protein; Provisional; Region: PRK06761 931276006743 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276006744 Right handed beta helix region; Region: Beta_helix; pfam13229 931276006745 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 931276006746 Uncharacterized conserved protein [Function unknown]; Region: COG1262 931276006747 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 931276006748 Hemerythrin; Region: Hemerythrin; cd12107 931276006749 Fe binding site [ion binding]; other site 931276006750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276006751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276006752 dimer interface [polypeptide binding]; other site 931276006753 phosphorylation site [posttranslational modification] 931276006754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276006755 ATP binding site [chemical binding]; other site 931276006756 Mg2+ binding site [ion binding]; other site 931276006757 G-X-G motif; other site 931276006758 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931276006759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276006760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276006761 Walker A/P-loop; other site 931276006762 ATP binding site [chemical binding]; other site 931276006763 Q-loop/lid; other site 931276006764 ABC transporter signature motif; other site 931276006765 Walker B; other site 931276006766 D-loop; other site 931276006767 H-loop/switch region; other site 931276006768 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931276006769 ABC-2 type transporter; Region: ABC2_membrane; cl17235 931276006770 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 931276006771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276006772 motif II; other site 931276006773 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276006774 dimerization interface [polypeptide binding]; other site 931276006775 putative DNA binding site [nucleotide binding]; other site 931276006776 putative Zn2+ binding site [ion binding]; other site 931276006777 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276006778 Accessory gene regulator B; Region: AgrB; pfam04647 931276006779 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 931276006780 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 931276006781 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276006782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276006783 metal binding site [ion binding]; metal-binding site 931276006784 active site 931276006785 I-site; other site 931276006786 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276006787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276006788 Zn2+ binding site [ion binding]; other site 931276006789 Mg2+ binding site [ion binding]; other site 931276006790 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 931276006791 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 931276006792 Cache domain; Region: Cache_1; pfam02743 931276006793 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276006794 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006795 dimer interface [polypeptide binding]; other site 931276006796 putative CheW interface [polypeptide binding]; other site 931276006797 Coenzyme A transferase; Region: CoA_trans; cl17247 931276006798 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 931276006799 Cupin domain; Region: Cupin_2; pfam07883 931276006800 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 931276006801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276006802 NAD(P) binding site [chemical binding]; other site 931276006803 active site 931276006804 Putative cyclase; Region: Cyclase; pfam04199 931276006805 Putative cyclase; Region: Cyclase; cl00814 931276006806 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 931276006807 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 931276006808 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 931276006809 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 931276006810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276006811 PAS domain; Region: PAS_9; pfam13426 931276006812 putative active site [active] 931276006813 heme pocket [chemical binding]; other site 931276006814 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 931276006815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276006816 Walker A motif; other site 931276006817 ATP binding site [chemical binding]; other site 931276006818 Walker B motif; other site 931276006819 arginine finger; other site 931276006820 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 931276006821 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 931276006822 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276006823 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276006824 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931276006825 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 931276006826 active site 931276006827 FMN binding site [chemical binding]; other site 931276006828 substrate binding site [chemical binding]; other site 931276006829 homotetramer interface [polypeptide binding]; other site 931276006830 catalytic residue [active] 931276006831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276006832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276006833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276006834 dimerization interface [polypeptide binding]; other site 931276006835 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 931276006836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276006837 NAD(P) binding site [chemical binding]; other site 931276006838 active site 931276006839 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276006840 dimer interface [polypeptide binding]; other site 931276006841 putative CheW interface [polypeptide binding]; other site 931276006842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276006843 dimerization interface [polypeptide binding]; other site 931276006844 putative DNA binding site [nucleotide binding]; other site 931276006845 putative Zn2+ binding site [ion binding]; other site 931276006846 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931276006847 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276006848 active site 931276006849 FMN binding site [chemical binding]; other site 931276006850 substrate binding site [chemical binding]; other site 931276006851 putative catalytic residue [active] 931276006852 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 931276006853 Ca binding site [ion binding]; other site 931276006854 carbohydrate binding site [chemical binding]; other site 931276006855 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 931276006856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276006857 Coenzyme A binding pocket [chemical binding]; other site 931276006858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276006859 Zn2+ binding site [ion binding]; other site 931276006860 Mg2+ binding site [ion binding]; other site 931276006861 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 931276006862 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 931276006863 active site 931276006864 catalytic residues [active] 931276006865 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 931276006866 RibD C-terminal domain; Region: RibD_C; cl17279 931276006867 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276006868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276006869 dimerization interface [polypeptide binding]; other site 931276006870 putative DNA binding site [nucleotide binding]; other site 931276006871 putative Zn2+ binding site [ion binding]; other site 931276006872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276006873 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931276006874 active site 931276006875 metal binding site [ion binding]; metal-binding site 931276006876 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 931276006877 4Fe-4S binding domain; Region: Fer4; pfam00037 931276006878 DJ-1 family protein; Region: not_thiJ; TIGR01383 931276006879 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 931276006880 conserved cys residue [active] 931276006881 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931276006882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276006883 DNA-binding site [nucleotide binding]; DNA binding site 931276006884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276006885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276006886 homodimer interface [polypeptide binding]; other site 931276006887 catalytic residue [active] 931276006888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276006889 Coenzyme A binding pocket [chemical binding]; other site 931276006890 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276006891 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 931276006892 catalytic site [active] 931276006893 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 931276006894 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276006895 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276006896 DNA binding residues [nucleotide binding] 931276006897 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 931276006898 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931276006899 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931276006900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276006901 DNA-binding site [nucleotide binding]; DNA binding site 931276006902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276006903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276006904 homodimer interface [polypeptide binding]; other site 931276006905 catalytic residue [active] 931276006906 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276006907 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276006908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006909 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276006910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276006912 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276006913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276006914 dimer interface [polypeptide binding]; other site 931276006915 conserved gate region; other site 931276006916 putative PBP binding loops; other site 931276006917 ABC-ATPase subunit interface; other site 931276006918 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276006919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276006920 dimer interface [polypeptide binding]; other site 931276006921 conserved gate region; other site 931276006922 putative PBP binding loops; other site 931276006923 ABC-ATPase subunit interface; other site 931276006924 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 931276006925 Melibiase; Region: Melibiase; pfam02065 931276006926 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276006927 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 931276006928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276006930 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 931276006931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276006932 Zn2+ binding site [ion binding]; other site 931276006933 Mg2+ binding site [ion binding]; other site 931276006934 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276006935 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276006936 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 931276006937 Predicted membrane protein [Function unknown]; Region: COG2364 931276006938 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276006939 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276006940 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276006941 putative active site [active] 931276006942 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 931276006943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276006944 active site 931276006945 motif I; other site 931276006946 motif II; other site 931276006947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 931276006948 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276006949 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931276006950 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 931276006951 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276006952 active site 931276006953 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276006955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276006956 putative substrate translocation pore; other site 931276006957 maltose O-acetyltransferase; Provisional; Region: PRK10092 931276006958 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 931276006959 active site 931276006960 substrate binding site [chemical binding]; other site 931276006961 trimer interface [polypeptide binding]; other site 931276006962 CoA binding site [chemical binding]; other site 931276006963 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 931276006964 FMN binding site [chemical binding]; other site 931276006965 dimer interface [polypeptide binding]; other site 931276006966 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 931276006967 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276006968 DNA binding residues [nucleotide binding] 931276006969 dimer interface [polypeptide binding]; other site 931276006970 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931276006971 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 931276006972 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 931276006973 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 931276006974 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 931276006975 metal binding site [ion binding]; metal-binding site 931276006976 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276006977 Predicted permeases [General function prediction only]; Region: COG0701 931276006978 TIGR03943 family protein; Region: TIGR03943 931276006979 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 931276006980 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276006981 putative active site [active] 931276006982 putative metal binding site [ion binding]; other site 931276006983 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931276006984 catalytic residues [active] 931276006985 EamA-like transporter family; Region: EamA; pfam00892 931276006986 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931276006987 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 931276006988 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276006989 active site turn [active] 931276006990 phosphorylation site [posttranslational modification] 931276006991 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276006992 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 931276006993 HPr interaction site; other site 931276006994 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276006995 active site 931276006996 phosphorylation site [posttranslational modification] 931276006997 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276006998 beta-galactosidase; Region: BGL; TIGR03356 931276006999 transcriptional antiterminator BglG; Provisional; Region: PRK09772 931276007000 CAT RNA binding domain; Region: CAT_RBD; smart01061 931276007001 PRD domain; Region: PRD; pfam00874 931276007002 PRD domain; Region: PRD; pfam00874 931276007003 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931276007004 FGGY family of carbohydrate kinases; Region: FGGY; cd00366 931276007005 N- and C-terminal domain interface [polypeptide binding]; other site 931276007006 active site 931276007007 MgATP binding site [chemical binding]; other site 931276007008 catalytic site [active] 931276007009 metal binding site [ion binding]; metal-binding site 931276007010 carbohydrate binding site [chemical binding]; other site 931276007011 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 931276007012 Mor transcription activator family; Region: Mor; cl02360 931276007013 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 931276007014 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 931276007015 molybdopterin cofactor binding site; other site 931276007016 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 931276007017 putative molybdopterin cofactor binding site; other site 931276007018 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 931276007019 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931276007020 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 931276007021 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276007022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276007023 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276007024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276007025 dimer interface [polypeptide binding]; other site 931276007026 putative CheW interface [polypeptide binding]; other site 931276007027 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 931276007028 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 931276007029 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 931276007030 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 931276007031 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276007032 ligand binding site [chemical binding]; other site 931276007033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276007034 HAMP domain; Region: HAMP; pfam00672 931276007035 Histidine kinase; Region: His_kinase; pfam06580 931276007036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007037 ATP binding site [chemical binding]; other site 931276007038 Mg2+ binding site [ion binding]; other site 931276007039 G-X-G motif; other site 931276007040 Response regulator receiver domain; Region: Response_reg; pfam00072 931276007041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007042 active site 931276007043 phosphorylation site [posttranslational modification] 931276007044 intermolecular recognition site; other site 931276007045 dimerization interface [polypeptide binding]; other site 931276007046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276007047 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276007048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276007049 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 931276007050 Peptidase family M28; Region: Peptidase_M28; pfam04389 931276007051 metal binding site [ion binding]; metal-binding site 931276007052 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 931276007053 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 931276007054 putative ligand binding site [chemical binding]; other site 931276007055 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 931276007056 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 931276007057 Walker A/P-loop; other site 931276007058 ATP binding site [chemical binding]; other site 931276007059 Q-loop/lid; other site 931276007060 ABC transporter signature motif; other site 931276007061 Walker B; other site 931276007062 D-loop; other site 931276007063 H-loop/switch region; other site 931276007064 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 931276007065 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276007066 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 931276007067 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 931276007068 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276007069 TM-ABC transporter signature motif; other site 931276007070 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276007071 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276007072 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276007073 dimer interface [polypeptide binding]; other site 931276007074 putative CheW interface [polypeptide binding]; other site 931276007075 xylose isomerase; Provisional; Region: PRK05474 931276007076 xylose isomerase; Region: xylose_isom_A; TIGR02630 931276007077 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 931276007078 N- and C-terminal domain interface [polypeptide binding]; other site 931276007079 D-xylulose kinase; Region: XylB; TIGR01312 931276007080 active site 931276007081 MgATP binding site [chemical binding]; other site 931276007082 catalytic site [active] 931276007083 metal binding site [ion binding]; metal-binding site 931276007084 xylulose binding site [chemical binding]; other site 931276007085 homodimer interface [polypeptide binding]; other site 931276007086 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276007087 putative DNA binding site [nucleotide binding]; other site 931276007088 putative Zn2+ binding site [ion binding]; other site 931276007089 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276007090 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931276007091 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 931276007092 active site 931276007093 intersubunit interactions; other site 931276007094 catalytic residue [active] 931276007095 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 931276007096 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931276007097 TPP-binding site [chemical binding]; other site 931276007098 dimer interface [polypeptide binding]; other site 931276007099 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276007100 PYR/PP interface [polypeptide binding]; other site 931276007101 dimer interface [polypeptide binding]; other site 931276007102 TPP binding site [chemical binding]; other site 931276007103 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276007104 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 931276007105 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 931276007106 hexamer (dimer of trimers) interface [polypeptide binding]; other site 931276007107 trimer interface [polypeptide binding]; other site 931276007108 substrate binding site [chemical binding]; other site 931276007109 Mn binding site [ion binding]; other site 931276007110 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276007111 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276007112 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276007113 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276007114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276007115 MarR family; Region: MarR; pfam01047 931276007116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276007117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276007118 putative substrate translocation pore; other site 931276007119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276007120 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276007121 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276007122 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 931276007123 DNA binding residues [nucleotide binding] 931276007124 dimer interface [polypeptide binding]; other site 931276007125 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276007126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276007127 non-specific DNA binding site [nucleotide binding]; other site 931276007128 salt bridge; other site 931276007129 sequence-specific DNA binding site [nucleotide binding]; other site 931276007130 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 931276007131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276007132 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 931276007133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276007134 Coenzyme A binding pocket [chemical binding]; other site 931276007135 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 931276007136 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 931276007137 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 931276007138 active site 931276007139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276007140 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276007141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276007142 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276007143 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276007144 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276007145 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276007146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276007147 HAMP domain; Region: HAMP; pfam00672 931276007148 dimerization interface [polypeptide binding]; other site 931276007149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276007150 dimer interface [polypeptide binding]; other site 931276007151 phosphorylation site [posttranslational modification] 931276007152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007153 ATP binding site [chemical binding]; other site 931276007154 Mg2+ binding site [ion binding]; other site 931276007155 G-X-G motif; other site 931276007156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276007157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007158 active site 931276007159 phosphorylation site [posttranslational modification] 931276007160 intermolecular recognition site; other site 931276007161 dimerization interface [polypeptide binding]; other site 931276007162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276007163 DNA binding site [nucleotide binding] 931276007164 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276007165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276007166 dimer interface [polypeptide binding]; other site 931276007167 putative CheW interface [polypeptide binding]; other site 931276007168 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 931276007169 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 931276007170 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276007171 beta-galactosidase; Region: BGL; TIGR03356 931276007172 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 931276007173 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276007174 Coenzyme A binding pocket [chemical binding]; other site 931276007175 Membrane transport protein; Region: Mem_trans; cl09117 931276007176 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 931276007177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276007178 motif II; other site 931276007179 Pleckstrin homology-like domain; Region: PH-like; cl17171 931276007180 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 931276007181 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931276007182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276007183 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 931276007184 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 931276007185 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 931276007186 substrate binding pocket [chemical binding]; other site 931276007187 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 931276007188 B12 binding site [chemical binding]; other site 931276007189 cobalt ligand [ion binding]; other site 931276007190 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931276007191 Bacterial SH3 domain; Region: SH3_3; cl17532 931276007192 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 931276007193 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 931276007194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276007195 Walker A/P-loop; other site 931276007196 ATP binding site [chemical binding]; other site 931276007197 Q-loop/lid; other site 931276007198 ABC transporter signature motif; other site 931276007199 Walker B; other site 931276007200 D-loop; other site 931276007201 H-loop/switch region; other site 931276007202 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 931276007203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276007204 DNA-binding site [nucleotide binding]; DNA binding site 931276007205 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 931276007206 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 931276007207 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276007208 active site turn [active] 931276007209 phosphorylation site [posttranslational modification] 931276007210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276007211 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 931276007212 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 931276007213 Ca binding site [ion binding]; other site 931276007214 active site 931276007215 catalytic site [active] 931276007216 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 931276007217 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 931276007218 ApbE family; Region: ApbE; pfam02424 931276007219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 931276007220 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276007221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007222 active site 931276007223 phosphorylation site [posttranslational modification] 931276007224 intermolecular recognition site; other site 931276007225 dimerization interface [polypeptide binding]; other site 931276007226 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 931276007227 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 931276007228 trimer interface [polypeptide binding]; other site 931276007229 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 931276007230 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 931276007231 Cache domain; Region: Cache_1; pfam02743 931276007232 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276007233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276007234 dimerization interface [polypeptide binding]; other site 931276007235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276007236 PAS fold; Region: PAS_3; pfam08447 931276007237 putative active site [active] 931276007238 heme pocket [chemical binding]; other site 931276007239 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276007240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276007241 metal binding site [ion binding]; metal-binding site 931276007242 active site 931276007243 I-site; other site 931276007244 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931276007245 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 931276007246 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 931276007247 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 931276007248 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276007249 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 931276007250 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 931276007251 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 931276007252 PilZ domain; Region: PilZ; pfam07238 931276007253 drug efflux system protein MdtG; Provisional; Region: PRK09874 931276007254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276007255 putative substrate translocation pore; other site 931276007256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276007257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276007258 WHG domain; Region: WHG; pfam13305 931276007259 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276007260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276007261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276007262 Walker A/P-loop; other site 931276007263 ATP binding site [chemical binding]; other site 931276007264 Q-loop/lid; other site 931276007265 ABC transporter signature motif; other site 931276007266 Walker B; other site 931276007267 D-loop; other site 931276007268 H-loop/switch region; other site 931276007269 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276007270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276007271 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931276007272 Walker A/P-loop; other site 931276007273 ATP binding site [chemical binding]; other site 931276007274 Q-loop/lid; other site 931276007275 ABC transporter signature motif; other site 931276007276 Walker B; other site 931276007277 D-loop; other site 931276007278 H-loop/switch region; other site 931276007279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 931276007280 Cache domain; Region: Cache_1; pfam02743 931276007281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276007282 dimerization interface [polypeptide binding]; other site 931276007283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276007284 dimer interface [polypeptide binding]; other site 931276007285 phosphorylation site [posttranslational modification] 931276007286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007287 ATP binding site [chemical binding]; other site 931276007288 Mg2+ binding site [ion binding]; other site 931276007289 G-X-G motif; other site 931276007290 Response regulator receiver domain; Region: Response_reg; pfam00072 931276007291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007292 active site 931276007293 phosphorylation site [posttranslational modification] 931276007294 intermolecular recognition site; other site 931276007295 dimerization interface [polypeptide binding]; other site 931276007296 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 931276007297 putative binding surface; other site 931276007298 active site 931276007299 Response regulator receiver domain; Region: Response_reg; pfam00072 931276007300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007301 active site 931276007302 phosphorylation site [posttranslational modification] 931276007303 intermolecular recognition site; other site 931276007304 dimerization interface [polypeptide binding]; other site 931276007305 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276007306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276007307 metal binding site [ion binding]; metal-binding site 931276007308 active site 931276007309 I-site; other site 931276007310 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276007311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276007312 Zn2+ binding site [ion binding]; other site 931276007313 Mg2+ binding site [ion binding]; other site 931276007314 FOG: CBS domain [General function prediction only]; Region: COG0517 931276007315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 931276007316 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 931276007317 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276007318 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276007319 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276007320 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 931276007321 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931276007322 active site 931276007323 CheD chemotactic sensory transduction; Region: CheD; cl00810 931276007324 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 931276007325 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 931276007326 Hemerythrin; Region: Hemerythrin; cd12107 931276007327 Fe binding site [ion binding]; other site 931276007328 Rubrerythrin [Energy production and conversion]; Region: COG1592 931276007329 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 931276007330 binuclear metal center [ion binding]; other site 931276007331 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931276007332 iron binding site [ion binding]; other site 931276007333 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 931276007334 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 931276007335 non-heme iron binding site [ion binding]; other site 931276007336 dimer interface [polypeptide binding]; other site 931276007337 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 931276007338 non-heme iron binding site [ion binding]; other site 931276007339 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 931276007340 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 931276007341 non-heme iron binding site [ion binding]; other site 931276007342 dimer interface [polypeptide binding]; other site 931276007343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276007344 H-loop/switch region; other site 931276007345 Response regulator receiver domain; Region: Response_reg; pfam00072 931276007346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007347 active site 931276007348 phosphorylation site [posttranslational modification] 931276007349 intermolecular recognition site; other site 931276007350 dimerization interface [polypeptide binding]; other site 931276007351 HDOD domain; Region: HDOD; pfam08668 931276007352 Uncharacterized conserved protein [Function unknown]; Region: COG3287 931276007353 FIST N domain; Region: FIST; pfam08495 931276007354 FIST C domain; Region: FIST_C; pfam10442 931276007355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007356 ATP binding site [chemical binding]; other site 931276007357 Mg2+ binding site [ion binding]; other site 931276007358 G-X-G motif; other site 931276007359 Response regulator receiver domain; Region: Response_reg; pfam00072 931276007360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007361 active site 931276007362 phosphorylation site [posttranslational modification] 931276007363 intermolecular recognition site; other site 931276007364 dimerization interface [polypeptide binding]; other site 931276007365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 931276007366 dimer interface [polypeptide binding]; other site 931276007367 phosphorylation site [posttranslational modification] 931276007368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007369 ATP binding site [chemical binding]; other site 931276007370 Mg2+ binding site [ion binding]; other site 931276007371 G-X-G motif; other site 931276007372 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 931276007373 diiron binding motif [ion binding]; other site 931276007374 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 931276007375 dimer interface [polypeptide binding]; other site 931276007376 FMN binding site [chemical binding]; other site 931276007377 NADPH bind site [chemical binding]; other site 931276007378 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 931276007379 ArsC family; Region: ArsC; pfam03960 931276007380 putative ArsC-like catalytic residues; other site 931276007381 putative TRX-like catalytic residues [active] 931276007382 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 931276007383 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 931276007384 nucleotide binding site [chemical binding]; other site 931276007385 putative NEF/HSP70 interaction site [polypeptide binding]; other site 931276007386 SBD interface [polypeptide binding]; other site 931276007387 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 931276007388 HSP70 interaction site [polypeptide binding]; other site 931276007389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276007390 binding surface 931276007391 Tetratricopeptide repeat; Region: TPR_16; pfam13432 931276007392 TPR motif; other site 931276007393 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 931276007394 oligoendopeptidase F; Region: pepF; TIGR00181 931276007395 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 931276007396 active site 931276007397 Zn binding site [ion binding]; other site 931276007398 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276007399 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931276007400 4Fe-4S binding domain; Region: Fer4; pfam00037 931276007401 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931276007402 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 931276007403 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 931276007404 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 931276007405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276007406 putative active site [active] 931276007407 heme pocket [chemical binding]; other site 931276007408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276007409 dimer interface [polypeptide binding]; other site 931276007410 phosphorylation site [posttranslational modification] 931276007411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007412 ATP binding site [chemical binding]; other site 931276007413 Mg2+ binding site [ion binding]; other site 931276007414 G-X-G motif; other site 931276007415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276007416 Coenzyme A binding pocket [chemical binding]; other site 931276007417 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 931276007418 nudix motif; other site 931276007419 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 931276007420 BioY family; Region: BioY; pfam02632 931276007421 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 931276007422 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 931276007423 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 931276007424 putative active site; other site 931276007425 catalytic triad [active] 931276007426 putative dimer interface [polypeptide binding]; other site 931276007427 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 931276007428 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 931276007429 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 931276007430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007431 G-X-G motif; other site 931276007432 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 931276007433 peptidase T; Region: peptidase-T; TIGR01882 931276007434 metal binding site [ion binding]; metal-binding site 931276007435 dimer interface [polypeptide binding]; other site 931276007436 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 931276007437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931276007438 ATP binding site [chemical binding]; other site 931276007439 putative Mg++ binding site [ion binding]; other site 931276007440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276007441 nucleotide binding region [chemical binding]; other site 931276007442 ATP-binding site [chemical binding]; other site 931276007443 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 931276007444 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 931276007445 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 931276007446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276007447 active site 931276007448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 931276007449 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 931276007450 NlpC/P60 family; Region: NLPC_P60; pfam00877 931276007451 Protein of unknown function (DUF503); Region: DUF503; pfam04456 931276007452 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 931276007453 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 931276007454 Predicted membrane protein [Function unknown]; Region: COG2364 931276007455 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276007456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276007457 binding surface 931276007458 TPR motif; other site 931276007459 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276007460 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276007461 metal binding site [ion binding]; metal-binding site 931276007462 active site 931276007463 I-site; other site 931276007464 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931276007465 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276007466 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276007467 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 931276007468 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 931276007469 ornithine carbamoyltransferase; Validated; Region: PRK02102 931276007470 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 931276007471 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 931276007472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276007473 Coenzyme A binding pocket [chemical binding]; other site 931276007474 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 931276007475 nudix motif; other site 931276007476 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 931276007477 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 931276007478 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 931276007479 Repair protein; Region: Repair_PSII; pfam04536 931276007480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276007481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007482 active site 931276007483 phosphorylation site [posttranslational modification] 931276007484 intermolecular recognition site; other site 931276007485 dimerization interface [polypeptide binding]; other site 931276007486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276007487 DNA binding site [nucleotide binding] 931276007488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276007489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276007490 dimerization interface [polypeptide binding]; other site 931276007491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276007492 dimer interface [polypeptide binding]; other site 931276007493 phosphorylation site [posttranslational modification] 931276007494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007495 ATP binding site [chemical binding]; other site 931276007496 Mg2+ binding site [ion binding]; other site 931276007497 G-X-G motif; other site 931276007498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276007499 binding surface 931276007500 TPR motif; other site 931276007501 TPR repeat; Region: TPR_11; pfam13414 931276007502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276007503 binding surface 931276007504 TPR repeat; Region: TPR_11; pfam13414 931276007505 TPR motif; other site 931276007506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276007507 binding surface 931276007508 TPR motif; other site 931276007509 TPR repeat; Region: TPR_11; pfam13414 931276007510 TPR repeat; Region: TPR_11; pfam13414 931276007511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276007512 binding surface 931276007513 TPR motif; other site 931276007514 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276007515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276007516 binding surface 931276007517 TPR motif; other site 931276007518 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 931276007519 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 931276007520 nucleotide binding site [chemical binding]; other site 931276007521 putative NEF/HSP70 interaction site [polypeptide binding]; other site 931276007522 SBD interface [polypeptide binding]; other site 931276007523 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276007524 EamA-like transporter family; Region: EamA; pfam00892 931276007525 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276007526 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276007527 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931276007528 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 931276007529 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931276007530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276007531 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276007532 active site 931276007533 motif I; other site 931276007534 motif II; other site 931276007535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276007536 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 931276007537 Pyruvate formate lyase 1; Region: PFL1; cd01678 931276007538 coenzyme A binding site [chemical binding]; other site 931276007539 active site 931276007540 catalytic residues [active] 931276007541 glycine loop; other site 931276007542 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 931276007543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276007544 FeS/SAM binding site; other site 931276007545 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 931276007546 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276007547 ligand binding site [chemical binding]; other site 931276007548 flexible hinge region; other site 931276007549 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 931276007550 putative switch regulator; other site 931276007551 non-specific DNA interactions [nucleotide binding]; other site 931276007552 DNA binding site [nucleotide binding] 931276007553 sequence specific DNA binding site [nucleotide binding]; other site 931276007554 putative cAMP binding site [chemical binding]; other site 931276007555 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931276007556 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 931276007557 Protein of unknown function (DUF975); Region: DUF975; cl10504 931276007558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276007559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276007560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276007561 dimerization interface [polypeptide binding]; other site 931276007562 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 931276007563 Isochorismatase family; Region: Isochorismatase; pfam00857 931276007564 catalytic triad [active] 931276007565 conserved cis-peptide bond; other site 931276007566 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 931276007567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 931276007568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276007569 Coenzyme A binding pocket [chemical binding]; other site 931276007570 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 931276007571 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276007572 Sensory domain found in PocR; Region: PocR; pfam10114 931276007573 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931276007574 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 931276007575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276007576 putative active site [active] 931276007577 heme pocket [chemical binding]; other site 931276007578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276007579 dimer interface [polypeptide binding]; other site 931276007580 phosphorylation site [posttranslational modification] 931276007581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276007582 ATP binding site [chemical binding]; other site 931276007583 Mg2+ binding site [ion binding]; other site 931276007584 G-X-G motif; other site 931276007585 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 931276007586 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 931276007587 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 931276007588 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 931276007589 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 931276007590 lysine transporter; Provisional; Region: PRK10836 931276007591 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276007592 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 931276007593 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 931276007594 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276007595 active site 931276007596 HIGH motif; other site 931276007597 nucleotide binding site [chemical binding]; other site 931276007598 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276007599 active site 931276007600 KMSKS motif; other site 931276007601 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 931276007602 tRNA binding surface [nucleotide binding]; other site 931276007603 anticodon binding site; other site 931276007604 Predicted membrane protein [Function unknown]; Region: COG4129 931276007605 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 931276007606 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 931276007607 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 931276007608 Lipase (class 2); Region: Lipase_2; pfam01674 931276007609 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276007610 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276007611 Zn2+ binding site [ion binding]; other site 931276007612 Mg2+ binding site [ion binding]; other site 931276007613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276007614 Zn2+ binding site [ion binding]; other site 931276007615 Mg2+ binding site [ion binding]; other site 931276007616 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 931276007617 active site 931276007618 P-loop; other site 931276007619 phosphorylation site [posttranslational modification] 931276007620 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276007621 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 931276007622 DNA binding residues [nucleotide binding] 931276007623 dimer interface [polypeptide binding]; other site 931276007624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276007625 S-adenosylmethionine binding site [chemical binding]; other site 931276007626 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 931276007627 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 931276007628 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931276007629 Rubredoxin; Region: Rubredoxin; pfam00301 931276007630 iron binding site [ion binding]; other site 931276007631 Rubrerythrin [Energy production and conversion]; Region: COG1592 931276007632 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 931276007633 diiron binding motif [ion binding]; other site 931276007634 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 931276007635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276007636 motif II; other site 931276007637 3D domain; Region: 3D; cl01439 931276007638 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931276007639 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 931276007640 synthetase active site [active] 931276007641 NTP binding site [chemical binding]; other site 931276007642 metal binding site [ion binding]; metal-binding site 931276007643 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 931276007644 FMN binding site [chemical binding]; other site 931276007645 dimer interface [polypeptide binding]; other site 931276007646 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931276007647 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 931276007648 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276007649 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276007650 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 931276007651 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 931276007652 catalytic triad [active] 931276007653 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 931276007654 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 931276007655 catalytic triad [active] 931276007656 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276007657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276007658 active site 931276007659 phosphorylation site [posttranslational modification] 931276007660 intermolecular recognition site; other site 931276007661 dimerization interface [polypeptide binding]; other site 931276007662 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 931276007663 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931276007664 Walker A/P-loop; other site 931276007665 ATP binding site [chemical binding]; other site 931276007666 Q-loop/lid; other site 931276007667 ABC transporter signature motif; other site 931276007668 Walker B; other site 931276007669 D-loop; other site 931276007670 H-loop/switch region; other site 931276007671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276007672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276007673 Coenzyme A binding pocket [chemical binding]; other site 931276007674 Protein of unknown function, DUF488; Region: DUF488; pfam04343 931276007675 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 931276007676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 931276007677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 931276007678 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 931276007679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276007680 FeS/SAM binding site; other site 931276007681 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 931276007682 dimer interface [polypeptide binding]; other site 931276007683 pyridoxal binding site [chemical binding]; other site 931276007684 ATP binding site [chemical binding]; other site 931276007685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276007686 FeS/SAM binding site; other site 931276007687 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 931276007688 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 931276007689 RuvA N terminal domain; Region: RuvA_N; pfam01330 931276007690 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 931276007691 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 931276007692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276007693 Walker A motif; other site 931276007694 ATP binding site [chemical binding]; other site 931276007695 Walker B motif; other site 931276007696 arginine finger; other site 931276007697 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 931276007698 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 931276007699 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 931276007700 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 931276007701 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 931276007702 Preprotein translocase subunit; Region: YajC; pfam02699 931276007703 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 931276007704 protein-export membrane protein SecD; Region: secD; TIGR01129 931276007705 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 931276007706 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 931276007707 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 931276007708 Protein export membrane protein; Region: SecD_SecF; cl14618 931276007709 DHH family; Region: DHH; pfam01368 931276007710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276007711 active site 931276007712 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 931276007713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276007714 Zn2+ binding site [ion binding]; other site 931276007715 Mg2+ binding site [ion binding]; other site 931276007716 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931276007717 synthetase active site [active] 931276007718 NTP binding site [chemical binding]; other site 931276007719 metal binding site [ion binding]; metal-binding site 931276007720 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 931276007721 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 931276007722 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 931276007723 putative active site [active] 931276007724 dimerization interface [polypeptide binding]; other site 931276007725 putative tRNAtyr binding site [nucleotide binding]; other site 931276007726 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 931276007727 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 931276007728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276007729 FeS/SAM binding site; other site 931276007730 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 931276007731 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 931276007732 dimer interface [polypeptide binding]; other site 931276007733 motif 1; other site 931276007734 active site 931276007735 motif 2; other site 931276007736 motif 3; other site 931276007737 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 931276007738 anticodon binding site; other site 931276007739 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 931276007740 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 931276007741 dimer interface [polypeptide binding]; other site 931276007742 anticodon binding site; other site 931276007743 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 931276007744 homodimer interface [polypeptide binding]; other site 931276007745 motif 1; other site 931276007746 active site 931276007747 motif 2; other site 931276007748 GAD domain; Region: GAD; pfam02938 931276007749 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 931276007750 active site 931276007751 motif 3; other site 931276007752 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931276007753 flagellin; Provisional; Region: PRK12804 931276007754 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 931276007755 Protein of unknown function (DUF554); Region: DUF554; pfam04474 931276007756 Transcription antiterminator [Transcription]; Region: NusG; COG0250 931276007757 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 931276007758 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 931276007759 heterodimer interface [polypeptide binding]; other site 931276007760 homodimer interface [polypeptide binding]; other site 931276007761 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276007762 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 931276007763 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 931276007764 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 931276007765 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276007766 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 931276007767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276007768 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276007769 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931276007770 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 931276007771 Probable Catalytic site; other site 931276007772 acetylornithine deacetylase; Validated; Region: PRK08596 931276007773 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 931276007774 trimer interface [polypeptide binding]; other site 931276007775 active site 931276007776 substrate binding site [chemical binding]; other site 931276007777 CoA binding site [chemical binding]; other site 931276007778 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931276007779 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 931276007780 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 931276007781 substrate binding site; other site 931276007782 tetramer interface; other site 931276007783 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931276007784 Chain length determinant protein; Region: Wzz; cl15801 931276007785 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 931276007786 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 931276007787 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276007788 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 931276007789 active site 931276007790 catalytic triad [active] 931276007791 oxyanion hole [active] 931276007792 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 931276007793 Chain length determinant protein; Region: Wzz; cl15801 931276007794 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 931276007795 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276007796 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 931276007797 Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943 931276007798 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 931276007799 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276007800 putative homodimer interface [polypeptide binding]; other site 931276007801 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 931276007802 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931276007803 Probable Catalytic site; other site 931276007804 metal-binding site 931276007805 Acyltransferase family; Region: Acyl_transf_3; pfam01757 931276007806 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 931276007807 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 931276007808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276007809 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 931276007810 putative ligand binding site [chemical binding]; other site 931276007811 putative catalytic site [active] 931276007812 homoserine dehydrogenase; Provisional; Region: PRK06349 931276007813 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 931276007814 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 931276007815 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 931276007816 Probable zinc-binding domain; Region: zf-trcl; pfam13451 931276007817 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 931276007818 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 931276007819 ATP-binding site [chemical binding]; other site 931276007820 Sugar specificity; other site 931276007821 Pyrimidine base specificity; other site 931276007822 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 931276007823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276007824 active site 931276007825 motif I; other site 931276007826 motif II; other site 931276007827 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 931276007828 threonine dehydratase; Provisional; Region: PRK08198 931276007829 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 931276007830 tetramer interface [polypeptide binding]; other site 931276007831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276007832 catalytic residue [active] 931276007833 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 931276007834 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 931276007835 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276007836 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931276007837 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 931276007838 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 931276007839 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276007840 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276007841 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276007842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276007843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276007844 ABC transporter; Region: ABC_tran_2; pfam12848 931276007845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276007846 YtxC-like family; Region: YtxC; pfam08812 931276007847 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 931276007848 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 931276007849 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 931276007850 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 931276007851 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 931276007852 23S rRNA binding site [nucleotide binding]; other site 931276007853 L21 binding site [polypeptide binding]; other site 931276007854 L13 binding site [polypeptide binding]; other site 931276007855 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 931276007856 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 931276007857 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 931276007858 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 931276007859 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 931276007860 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 931276007861 dimer interface [polypeptide binding]; other site 931276007862 motif 1; other site 931276007863 active site 931276007864 motif 2; other site 931276007865 motif 3; other site 931276007866 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 931276007867 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 931276007868 putative tRNA-binding site [nucleotide binding]; other site 931276007869 B3/4 domain; Region: B3_4; pfam03483 931276007870 tRNA synthetase B5 domain; Region: B5; smart00874 931276007871 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 931276007872 dimer interface [polypeptide binding]; other site 931276007873 motif 1; other site 931276007874 motif 3; other site 931276007875 motif 2; other site 931276007876 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 931276007877 cell division protein MraZ; Reviewed; Region: PRK00326 931276007878 MraZ protein; Region: MraZ; pfam02381 931276007879 MraZ protein; Region: MraZ; pfam02381 931276007880 MraW methylase family; Region: Methyltransf_5; pfam01795 931276007881 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 931276007882 Cell division protein FtsL; Region: FtsL; cl11433 931276007883 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 931276007884 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931276007885 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 931276007886 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 931276007887 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 931276007888 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 931276007889 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931276007890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 931276007891 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 931276007892 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 931276007893 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 931276007894 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 931276007895 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276007896 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931276007897 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 931276007898 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 931276007899 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276007900 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931276007901 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 931276007902 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 931276007903 Mg++ binding site [ion binding]; other site 931276007904 putative catalytic motif [active] 931276007905 putative substrate binding site [chemical binding]; other site 931276007906 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 931276007907 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 931276007908 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 931276007909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 931276007910 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 931276007911 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 931276007912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 931276007913 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 931276007914 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 931276007915 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931276007916 catalytic residue [active] 931276007917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 931276007918 YGGT family; Region: YGGT; pfam02325 931276007919 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 931276007920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276007921 RNA binding surface [nucleotide binding]; other site 931276007922 DivIVA protein; Region: DivIVA; pfam05103 931276007923 DivIVA domain; Region: DivI1A_domain; TIGR03544 931276007924 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 931276007925 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 931276007926 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 931276007927 ligand binding site [chemical binding]; other site 931276007928 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 931276007929 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 931276007930 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 931276007931 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276007932 RNA binding surface [nucleotide binding]; other site 931276007933 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 931276007934 active site 931276007935 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 931276007936 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 931276007937 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 931276007938 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 931276007939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276007940 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276007941 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276007942 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276007943 putative active site [active] 931276007944 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 931276007945 Domain of unknown function (DUF814); Region: DUF814; pfam05670 931276007946 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 931276007947 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 931276007948 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 931276007949 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 931276007950 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931276007951 Walker A motif; other site 931276007952 ATP binding site [chemical binding]; other site 931276007953 Walker B motif; other site 931276007954 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276007955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276007956 active site 931276007957 DNA binding site [nucleotide binding] 931276007958 Int/Topo IB signature motif; other site 931276007959 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931276007960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276007961 non-specific DNA binding site [nucleotide binding]; other site 931276007962 salt bridge; other site 931276007963 sequence-specific DNA binding site [nucleotide binding]; other site 931276007964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276007965 non-specific DNA binding site [nucleotide binding]; other site 931276007966 salt bridge; other site 931276007967 sequence-specific DNA binding site [nucleotide binding]; other site 931276007968 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 931276007969 Helix-turn-helix domain; Region: HTH_17; cl17695 931276007970 ORF6N domain; Region: ORF6N; pfam10543 931276007971 KTSC domain; Region: KTSC; pfam13619 931276007972 ERF superfamily; Region: ERF; pfam04404 931276007973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 931276007974 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 931276007975 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 931276007976 dimer interface [polypeptide binding]; other site 931276007977 ssDNA binding site [nucleotide binding]; other site 931276007978 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276007979 ERCC4 domain; Region: ERCC4; pfam02732 931276007980 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 931276007981 metal binding site [ion binding]; metal-binding site 931276007982 zinc finger; Region: ZnF_CHCC; smart00400 931276007983 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 931276007984 active site 931276007985 metal binding site [ion binding]; metal-binding site 931276007986 YopX protein; Region: YopX; pfam09643 931276007987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276007988 non-specific DNA binding site [nucleotide binding]; other site 931276007989 salt bridge; other site 931276007990 sequence-specific DNA binding site [nucleotide binding]; other site 931276007991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276007992 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 931276007993 active site 931276007994 DNA binding site [nucleotide binding] 931276007995 Int/Topo IB signature motif; other site 931276007996 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 931276007997 DNA-binding interface [nucleotide binding]; DNA binding site 931276007998 NUMOD4 motif; Region: NUMOD4; pfam07463 931276007999 HNH endonuclease; Region: HNH_3; pfam13392 931276008000 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 931276008001 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 931276008002 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 931276008003 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 931276008004 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 931276008005 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 931276008006 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 931276008007 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 931276008008 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 931276008009 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 931276008010 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 931276008011 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 931276008012 NlpC/P60 family; Region: NLPC_P60; pfam00877 931276008013 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 931276008014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 931276008015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 931276008016 catalytic residue [active] 931276008017 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 931276008018 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 931276008019 Baseplate J-like protein; Region: Baseplate_J; pfam04865 931276008020 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 931276008021 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 931276008022 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276008023 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276008024 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276008025 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276008026 Domain of unknown function DUF11; Region: DUF11; cl17728 931276008027 Haemolysin XhlA; Region: XhlA; pfam10779 931276008028 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 931276008029 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931276008030 active site 931276008031 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276008032 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276008033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276008034 non-specific DNA binding site [nucleotide binding]; other site 931276008035 salt bridge; other site 931276008036 sequence-specific DNA binding site [nucleotide binding]; other site 931276008037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276008038 elongation factor P; Validated; Region: PRK00529 931276008039 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 931276008040 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 931276008041 RNA binding site [nucleotide binding]; other site 931276008042 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 931276008043 RNA binding site [nucleotide binding]; other site 931276008044 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 931276008045 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 931276008046 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 931276008047 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 931276008048 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 931276008049 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 931276008050 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 931276008051 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 931276008052 Asp23 family; Region: Asp23; pfam03780 931276008053 transcription antitermination factor NusB; Region: nusB; TIGR01951 931276008054 putative RNA binding site [nucleotide binding]; other site 931276008055 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 931276008056 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 931276008057 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 931276008058 homodimer interface [polypeptide binding]; other site 931276008059 NADP binding site [chemical binding]; other site 931276008060 substrate binding site [chemical binding]; other site 931276008061 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 931276008062 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 931276008063 generic binding surface II; other site 931276008064 generic binding surface I; other site 931276008065 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 931276008066 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 931276008067 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 931276008068 substrate binding pocket [chemical binding]; other site 931276008069 chain length determination region; other site 931276008070 substrate-Mg2+ binding site; other site 931276008071 catalytic residues [active] 931276008072 aspartate-rich region 1; other site 931276008073 active site lid residues [active] 931276008074 aspartate-rich region 2; other site 931276008075 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 931276008076 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 931276008077 TPP-binding site; other site 931276008078 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276008079 PYR/PP interface [polypeptide binding]; other site 931276008080 dimer interface [polypeptide binding]; other site 931276008081 TPP binding site [chemical binding]; other site 931276008082 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276008083 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 931276008084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276008085 RNA binding surface [nucleotide binding]; other site 931276008086 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 931276008087 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 931276008088 ATP-NAD kinase; Region: NAD_kinase; pfam01513 931276008089 arginine repressor; Provisional; Region: argR; PRK00441 931276008090 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 931276008091 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 931276008092 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 931276008093 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 931276008094 Walker A/P-loop; other site 931276008095 ATP binding site [chemical binding]; other site 931276008096 Q-loop/lid; other site 931276008097 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 931276008098 Q-loop/lid; other site 931276008099 ABC transporter signature motif; other site 931276008100 Walker B; other site 931276008101 D-loop; other site 931276008102 H-loop/switch region; other site 931276008103 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 931276008104 protein binding site [polypeptide binding]; other site 931276008105 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 931276008106 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 931276008107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276008108 active site 931276008109 phosphorylation site [posttranslational modification] 931276008110 intermolecular recognition site; other site 931276008111 dimerization interface [polypeptide binding]; other site 931276008112 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 931276008113 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 931276008114 GIY-YIG motif/motif A; other site 931276008115 active site 931276008116 catalytic site [active] 931276008117 metal binding site [ion binding]; metal-binding site 931276008118 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 931276008119 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 931276008120 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276008121 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276008122 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276008123 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 931276008124 Domain of unknown function DUF11; Region: DUF11; cl17728 931276008125 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276008126 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276008127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276008128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276008129 dimer interface [polypeptide binding]; other site 931276008130 putative CheW interface [polypeptide binding]; other site 931276008131 PilZ domain; Region: PilZ; pfam07238 931276008132 uracil transporter; Provisional; Region: PRK10720 931276008133 TQXA domain; Region: TQXA_dom; TIGR03934 931276008134 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 931276008135 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 931276008136 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931276008137 catalytic core [active] 931276008138 TPR repeat; Region: TPR_11; pfam13414 931276008139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276008140 binding surface 931276008141 TPR motif; other site 931276008142 TPR repeat; Region: TPR_11; pfam13414 931276008143 stage V sporulation protein K; Region: spore_V_K; TIGR02881 931276008144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276008145 Walker A motif; other site 931276008146 ATP binding site [chemical binding]; other site 931276008147 Walker B motif; other site 931276008148 arginine finger; other site 931276008149 stage V sporulation protein K; Region: spore_V_K; TIGR02881 931276008150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276008151 Walker A motif; other site 931276008152 ATP binding site [chemical binding]; other site 931276008153 Walker B motif; other site 931276008154 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 931276008155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276008156 Walker A motif; other site 931276008157 ATP binding site [chemical binding]; other site 931276008158 Walker B motif; other site 931276008159 arginine finger; other site 931276008160 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276008161 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931276008162 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 931276008163 putative active site [active] 931276008164 metal binding site [ion binding]; metal-binding site 931276008165 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 931276008166 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 931276008167 FAD binding pocket [chemical binding]; other site 931276008168 FAD binding motif [chemical binding]; other site 931276008169 phosphate binding motif [ion binding]; other site 931276008170 beta-alpha-beta structure motif; other site 931276008171 NAD binding pocket [chemical binding]; other site 931276008172 Iron coordination center [ion binding]; other site 931276008173 putative oxidoreductase; Provisional; Region: PRK12831 931276008174 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276008175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276008176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276008177 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276008178 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 931276008179 NodB motif; other site 931276008180 active site 931276008181 catalytic site [active] 931276008182 Zn binding site [ion binding]; other site 931276008183 CAAX protease self-immunity; Region: Abi; pfam02517 931276008184 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931276008185 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 931276008186 putative ligand binding site [chemical binding]; other site 931276008187 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 931276008188 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 931276008189 Ligand binding site; other site 931276008190 Putative Catalytic site; other site 931276008191 DXD motif; other site 931276008192 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 931276008193 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 931276008194 Predicted integral membrane protein [Function unknown]; Region: COG5542 931276008195 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 931276008196 classical (c) SDRs; Region: SDR_c; cd05233 931276008197 NAD(P) binding site [chemical binding]; other site 931276008198 active site 931276008199 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 931276008200 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 931276008201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276008202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276008203 active site 931276008204 phosphorylation site [posttranslational modification] 931276008205 intermolecular recognition site; other site 931276008206 dimerization interface [polypeptide binding]; other site 931276008207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276008208 DNA binding site [nucleotide binding] 931276008209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276008210 dimerization interface [polypeptide binding]; other site 931276008211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276008212 dimer interface [polypeptide binding]; other site 931276008213 phosphorylation site [posttranslational modification] 931276008214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276008215 ATP binding site [chemical binding]; other site 931276008216 Mg2+ binding site [ion binding]; other site 931276008217 G-X-G motif; other site 931276008218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 931276008219 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 931276008220 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931276008221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276008222 dimerization interface [polypeptide binding]; other site 931276008223 putative DNA binding site [nucleotide binding]; other site 931276008224 putative Zn2+ binding site [ion binding]; other site 931276008225 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 931276008226 putative efflux protein, MATE family; Region: matE; TIGR00797 931276008227 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 931276008228 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 931276008229 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931276008230 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931276008231 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 931276008232 Uncharacterized conserved protein [Function unknown]; Region: COG2966 931276008233 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 931276008234 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 931276008235 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 931276008236 dimer interface [polypeptide binding]; other site 931276008237 active site 931276008238 glycine-pyridoxal phosphate binding site [chemical binding]; other site 931276008239 folate binding site [chemical binding]; other site 931276008240 DNA topoisomerase III; Provisional; Region: PRK07726 931276008241 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 931276008242 active site 931276008243 putative interdomain interaction site [polypeptide binding]; other site 931276008244 putative metal-binding site [ion binding]; other site 931276008245 putative nucleotide binding site [chemical binding]; other site 931276008246 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 931276008247 domain I; other site 931276008248 DNA binding groove [nucleotide binding] 931276008249 phosphate binding site [ion binding]; other site 931276008250 domain II; other site 931276008251 domain III; other site 931276008252 nucleotide binding site [chemical binding]; other site 931276008253 catalytic site [active] 931276008254 domain IV; other site 931276008255 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 931276008256 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 931276008257 Cache domain; Region: Cache_1; pfam02743 931276008258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276008259 dimerization interface [polypeptide binding]; other site 931276008260 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276008261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276008262 dimer interface [polypeptide binding]; other site 931276008263 putative CheW interface [polypeptide binding]; other site 931276008264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276008265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276008266 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 931276008267 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276008268 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276008269 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931276008270 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931276008271 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931276008272 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 931276008273 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 931276008274 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 931276008275 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 931276008276 ATP binding site [chemical binding]; other site 931276008277 substrate interface [chemical binding]; other site 931276008278 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 931276008279 E3 interaction residues; other site 931276008280 Ub thioester intermediate interaction residues; other site 931276008281 active site cysteine 931276008282 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 931276008283 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 931276008284 phosphopeptide binding site; other site 931276008285 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 931276008286 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 931276008287 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 931276008288 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 931276008289 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 931276008290 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 931276008291 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 931276008292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 931276008293 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 931276008294 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 931276008295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276008296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276008297 DNA binding residues [nucleotide binding] 931276008298 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 931276008299 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 931276008300 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 931276008301 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 931276008302 ScpA/B protein; Region: ScpA_ScpB; cl00598 931276008303 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 931276008304 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 931276008305 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 931276008306 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 931276008307 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 931276008308 hypothetical protein; Provisional; Region: PRK05802 931276008309 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 931276008310 FAD binding pocket [chemical binding]; other site 931276008311 FAD binding motif [chemical binding]; other site 931276008312 phosphate binding motif [ion binding]; other site 931276008313 beta-alpha-beta structure motif; other site 931276008314 NAD binding pocket [chemical binding]; other site 931276008315 Iron coordination center [ion binding]; other site 931276008316 Glucose inhibited division protein A; Region: GIDA; pfam01134 931276008317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276008318 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 931276008319 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 931276008320 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276008321 RNA binding surface [nucleotide binding]; other site 931276008322 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 931276008323 active site 931276008324 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276008325 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276008326 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276008327 putative active site [active] 931276008328 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 931276008329 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 931276008330 active site 931276008331 NTP binding site [chemical binding]; other site 931276008332 metal binding triad [ion binding]; metal-binding site 931276008333 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 931276008334 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 931276008335 Uncharacterized conserved protein [Function unknown]; Region: COG3287 931276008336 FIST N domain; Region: FIST; pfam08495 931276008337 FIST C domain; Region: FIST_C; pfam10442 931276008338 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276008339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276008340 dimer interface [polypeptide binding]; other site 931276008341 putative CheW interface [polypeptide binding]; other site 931276008342 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 931276008343 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931276008344 Walker A/P-loop; other site 931276008345 ATP binding site [chemical binding]; other site 931276008346 Q-loop/lid; other site 931276008347 ABC transporter signature motif; other site 931276008348 Walker B; other site 931276008349 D-loop; other site 931276008350 H-loop/switch region; other site 931276008351 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931276008352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276008353 dimer interface [polypeptide binding]; other site 931276008354 conserved gate region; other site 931276008355 putative PBP binding loops; other site 931276008356 ABC-ATPase subunit interface; other site 931276008357 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 931276008358 NMT1/THI5 like; Region: NMT1; pfam09084 931276008359 Putative serine esterase (DUF676); Region: DUF676; pfam05057 931276008360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276008361 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276008362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276008363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276008364 EamA-like transporter family; Region: EamA; pfam00892 931276008365 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931276008366 EamA-like transporter family; Region: EamA; pfam00892 931276008367 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 931276008368 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276008369 dimer interface [polypeptide binding]; other site 931276008370 putative CheW interface [polypeptide binding]; other site 931276008371 Response regulator receiver domain; Region: Response_reg; pfam00072 931276008372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276008373 active site 931276008374 phosphorylation site [posttranslational modification] 931276008375 intermolecular recognition site; other site 931276008376 dimerization interface [polypeptide binding]; other site 931276008377 HDOD domain; Region: HDOD; pfam08668 931276008378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276008379 dimer interface [polypeptide binding]; other site 931276008380 phosphorylation site [posttranslational modification] 931276008381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276008382 ATP binding site [chemical binding]; other site 931276008383 Mg2+ binding site [ion binding]; other site 931276008384 G-X-G motif; other site 931276008385 Response regulator receiver domain; Region: Response_reg; pfam00072 931276008386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276008387 active site 931276008388 phosphorylation site [posttranslational modification] 931276008389 intermolecular recognition site; other site 931276008390 dimerization interface [polypeptide binding]; other site 931276008391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276008392 dimer interface [polypeptide binding]; other site 931276008393 phosphorylation site [posttranslational modification] 931276008394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276008395 ATP binding site [chemical binding]; other site 931276008396 Mg2+ binding site [ion binding]; other site 931276008397 G-X-G motif; other site 931276008398 Cache domain; Region: Cache_1; pfam02743 931276008399 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276008400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931276008401 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276008402 dimer interface [polypeptide binding]; other site 931276008403 putative CheW interface [polypeptide binding]; other site 931276008404 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276008405 MarR family; Region: MarR_2; pfam12802 931276008406 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 931276008407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276008408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276008409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931276008410 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 931276008411 active site residue [active] 931276008412 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 931276008413 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 931276008414 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 931276008415 putative active site [active] 931276008416 catalytic site [active] 931276008417 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 931276008418 UbiA prenyltransferase family; Region: UbiA; pfam01040 931276008419 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 931276008420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276008421 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276008422 DNA binding residues [nucleotide binding] 931276008423 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 931276008424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276008425 dimerization interface [polypeptide binding]; other site 931276008426 putative DNA binding site [nucleotide binding]; other site 931276008427 putative Zn2+ binding site [ion binding]; other site 931276008428 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931276008429 metal-binding site [ion binding] 931276008430 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 931276008431 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 931276008432 metal-binding site [ion binding] 931276008433 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276008434 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 931276008435 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 931276008436 substrate binding site [chemical binding]; other site 931276008437 ATP binding site [chemical binding]; other site 931276008438 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 931276008439 Acyltransferase family; Region: Acyl_transf_3; pfam01757 931276008440 Acyltransferase family; Region: Acyl_transf_3; pfam01757 931276008441 Flavodoxin domain; Region: Flavodoxin_5; cl17428 931276008442 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276008443 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276008444 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 931276008445 FtsH Extracellular; Region: FtsH_ext; pfam06480 931276008446 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 931276008447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276008448 Walker A motif; other site 931276008449 ATP binding site [chemical binding]; other site 931276008450 Walker B motif; other site 931276008451 arginine finger; other site 931276008452 Peptidase family M41; Region: Peptidase_M41; pfam01434 931276008453 Protein of unknown function (DUF445); Region: DUF445; pfam04286 931276008454 Protein of unknown function (DUF445); Region: DUF445; pfam04286 931276008455 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 931276008456 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 931276008457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276008458 NAD(P) binding site [chemical binding]; other site 931276008459 active site 931276008460 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 931276008461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276008462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276008463 DNA binding residues [nucleotide binding] 931276008464 dimerization interface [polypeptide binding]; other site 931276008465 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931276008466 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276008467 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 931276008468 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 931276008469 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 931276008470 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 931276008471 Walker A/P-loop; other site 931276008472 ATP binding site [chemical binding]; other site 931276008473 Q-loop/lid; other site 931276008474 ABC transporter signature motif; other site 931276008475 Walker B; other site 931276008476 D-loop; other site 931276008477 H-loop/switch region; other site 931276008478 TOBE domain; Region: TOBE_2; pfam08402 931276008479 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 931276008480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276008481 dimer interface [polypeptide binding]; other site 931276008482 conserved gate region; other site 931276008483 putative PBP binding loops; other site 931276008484 ABC-ATPase subunit interface; other site 931276008485 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 931276008486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276008487 dimer interface [polypeptide binding]; other site 931276008488 conserved gate region; other site 931276008489 putative PBP binding loops; other site 931276008490 ABC-ATPase subunit interface; other site 931276008491 D-glutamate deacylase; Validated; Region: PRK09061 931276008492 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931276008493 active site 931276008494 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931276008495 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 931276008496 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 931276008497 tetramerization interface [polypeptide binding]; other site 931276008498 NAD(P) binding site [chemical binding]; other site 931276008499 catalytic residues [active] 931276008500 Helix-turn-helix domain; Region: HTH_38; pfam13936 931276008501 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 931276008502 Integrase core domain; Region: rve; pfam00665 931276008503 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 931276008504 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 931276008505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276008506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276008507 homodimer interface [polypeptide binding]; other site 931276008508 catalytic residue [active] 931276008509 Cupin domain; Region: Cupin_2; pfam07883 931276008510 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276008511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276008512 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276008513 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931276008514 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 931276008515 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 931276008516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276008517 putative frv operon regulatory protein; Provisional; Region: PRK09863 931276008518 HTH domain; Region: HTH_11; pfam08279 931276008519 Mga helix-turn-helix domain; Region: Mga; pfam05043 931276008520 PRD domain; Region: PRD; pfam00874 931276008521 PRD domain; Region: PRD; pfam00874 931276008522 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 931276008523 active site 931276008524 P-loop; other site 931276008525 phosphorylation site [posttranslational modification] 931276008526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931276008527 active site 931276008528 phosphorylation site [posttranslational modification] 931276008529 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276008530 active site 931276008531 P-loop; other site 931276008532 phosphorylation site [posttranslational modification] 931276008533 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 931276008534 active site 931276008535 P-loop; other site 931276008536 phosphorylation site [posttranslational modification] 931276008537 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276008538 methionine cluster; other site 931276008539 active site 931276008540 phosphorylation site [posttranslational modification] 931276008541 metal binding site [ion binding]; metal-binding site 931276008542 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276008543 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276008544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 931276008545 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276008546 substrate binding pocket [chemical binding]; other site 931276008547 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276008548 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 931276008549 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 931276008550 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276008551 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276008552 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276008553 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276008554 beta-galactosidase; Region: BGL; TIGR03356 931276008555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276008556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276008557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276008558 dimerization interface [polypeptide binding]; other site 931276008559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276008560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276008561 putative substrate translocation pore; other site 931276008562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 931276008563 PAS domain; Region: PAS_9; pfam13426 931276008564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276008565 PAS domain; Region: PAS_9; pfam13426 931276008566 putative active site [active] 931276008567 heme pocket [chemical binding]; other site 931276008568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276008569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276008570 metal binding site [ion binding]; metal-binding site 931276008571 active site 931276008572 I-site; other site 931276008573 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276008574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276008575 Zn2+ binding site [ion binding]; other site 931276008576 Mg2+ binding site [ion binding]; other site 931276008577 Cache domain; Region: Cache_1; pfam02743 931276008578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276008579 dimerization interface [polypeptide binding]; other site 931276008580 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276008581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276008582 dimer interface [polypeptide binding]; other site 931276008583 putative CheW interface [polypeptide binding]; other site 931276008584 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 931276008585 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 931276008586 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 931276008587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276008588 non-specific DNA binding site [nucleotide binding]; other site 931276008589 salt bridge; other site 931276008590 sequence-specific DNA binding site [nucleotide binding]; other site 931276008591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931276008592 binding surface 931276008593 TPR motif; other site 931276008594 acyl carrier protein; Provisional; Region: acpP; PRK00982 931276008595 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 931276008596 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 931276008597 FMN binding site [chemical binding]; other site 931276008598 substrate binding site [chemical binding]; other site 931276008599 putative catalytic residue [active] 931276008600 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 931276008601 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 931276008602 dimer interface [polypeptide binding]; other site 931276008603 active site 931276008604 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 931276008605 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 931276008606 carboxyltransferase (CT) interaction site; other site 931276008607 biotinylation site [posttranslational modification]; other site 931276008608 biotin carboxylase; Validated; Region: PRK05586 931276008609 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931276008610 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 931276008611 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 931276008612 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 931276008613 RNA polymerase subunit 9; Region: RPOL9; smart00661 931276008614 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 931276008615 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 931276008616 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 931276008617 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 931276008618 Condensation domain; Region: Condensation; pfam00668 931276008619 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276008620 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 931276008621 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 931276008622 acyl-activating enzyme (AAE) consensus motif; other site 931276008623 AMP binding site [chemical binding]; other site 931276008624 Condensation domain; Region: Condensation; pfam00668 931276008625 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 931276008626 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931276008627 classical (c) SDRs; Region: SDR_c; cd05233 931276008628 NAD(P) binding site [chemical binding]; other site 931276008629 active site 931276008630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276008631 putative substrate translocation pore; other site 931276008632 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 931276008633 acyl-CoA synthetase; Validated; Region: PRK09192 931276008634 acyl-activating enzyme (AAE) consensus motif; other site 931276008635 putative AMP binding site [chemical binding]; other site 931276008636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276008637 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276008638 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 931276008639 active site 931276008640 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 931276008641 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 931276008642 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 931276008643 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 931276008644 putative NADP binding site [chemical binding]; other site 931276008645 active site 931276008646 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 931276008647 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 931276008648 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 931276008649 active site 931276008650 FMN-binding domain; Region: FMN_bind; cl01081 931276008651 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 931276008652 GAF domain; Region: GAF; cl17456 931276008653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276008654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276008655 DNA binding residues [nucleotide binding] 931276008656 dimerization interface [polypeptide binding]; other site 931276008657 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 931276008658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931276008659 inhibitor-cofactor binding pocket; inhibition site 931276008660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276008661 catalytic residue [active] 931276008662 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276008663 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276008664 active site 931276008665 NAD binding site [chemical binding]; other site 931276008666 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276008667 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931276008668 DNA binding residues [nucleotide binding] 931276008669 putative dimer interface [polypeptide binding]; other site 931276008670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276008671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276008672 putative substrate translocation pore; other site 931276008673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276008674 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 931276008675 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 931276008676 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276008677 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276008678 MarR family; Region: MarR_2; pfam12802 931276008679 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 931276008680 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276008681 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 931276008682 DEAD/DEAH box helicase; Region: DEAD; pfam00270 931276008683 helicase superfamily c-terminal domain; Region: HELICc; smart00490 931276008684 Dehydratase family; Region: ILVD_EDD; cl00340 931276008685 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 931276008686 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 931276008687 Part of AAA domain; Region: AAA_19; pfam13245 931276008688 Family description; Region: UvrD_C_2; pfam13538 931276008689 Hemerythrin; Region: Hemerythrin; cd12107 931276008690 Fe binding site [ion binding]; other site 931276008691 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 931276008692 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 931276008693 NAD(P) binding site [chemical binding]; other site 931276008694 catalytic residues [active] 931276008695 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 931276008696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276008697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276008698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931276008699 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 931276008700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276008701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276008702 active site 931276008703 phosphorylation site [posttranslational modification] 931276008704 intermolecular recognition site; other site 931276008705 dimerization interface [polypeptide binding]; other site 931276008706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276008707 DNA binding site [nucleotide binding] 931276008708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276008709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276008710 dimer interface [polypeptide binding]; other site 931276008711 phosphorylation site [posttranslational modification] 931276008712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276008713 ATP binding site [chemical binding]; other site 931276008714 Mg2+ binding site [ion binding]; other site 931276008715 G-X-G motif; other site 931276008716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931276008717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 931276008718 active site 931276008719 catalytic tetrad [active] 931276008720 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 931276008721 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 931276008722 active site 931276008723 purine riboside binding site [chemical binding]; other site 931276008724 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276008725 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276008726 ligand binding site [chemical binding]; other site 931276008727 calcium binding site [ion binding]; other site 931276008728 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276008729 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276008730 ligand binding site [chemical binding]; other site 931276008731 calcium binding site [ion binding]; other site 931276008732 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 931276008733 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276008734 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276008735 ligand binding site [chemical binding]; other site 931276008736 calcium binding site [ion binding]; other site 931276008737 Hemerythrin-like domain; Region: Hr-like; cd12108 931276008738 Fe binding site [ion binding]; other site 931276008739 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 931276008740 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931276008741 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276008742 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 931276008743 active site 931276008744 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931276008745 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 931276008746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276008747 substrate binding pocket [chemical binding]; other site 931276008748 membrane-bound complex binding site; other site 931276008749 hinge residues; other site 931276008750 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 931276008751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276008752 dimer interface [polypeptide binding]; other site 931276008753 conserved gate region; other site 931276008754 putative PBP binding loops; other site 931276008755 ABC-ATPase subunit interface; other site 931276008756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276008757 dimer interface [polypeptide binding]; other site 931276008758 conserved gate region; other site 931276008759 putative PBP binding loops; other site 931276008760 ABC-ATPase subunit interface; other site 931276008761 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 931276008762 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 931276008763 Walker A/P-loop; other site 931276008764 ATP binding site [chemical binding]; other site 931276008765 Q-loop/lid; other site 931276008766 ABC transporter signature motif; other site 931276008767 Walker B; other site 931276008768 D-loop; other site 931276008769 H-loop/switch region; other site 931276008770 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 931276008771 L-aspartate oxidase; Provisional; Region: PRK06175 931276008772 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 931276008773 Ferredoxin [Energy production and conversion]; Region: COG1146 931276008774 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276008775 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 931276008776 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 931276008777 Active Sites [active] 931276008778 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 931276008779 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 931276008780 CysD dimerization site [polypeptide binding]; other site 931276008781 G1 box; other site 931276008782 putative GEF interaction site [polypeptide binding]; other site 931276008783 GTP/Mg2+ binding site [chemical binding]; other site 931276008784 Switch I region; other site 931276008785 G2 box; other site 931276008786 G3 box; other site 931276008787 Switch II region; other site 931276008788 G4 box; other site 931276008789 G5 box; other site 931276008790 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 931276008791 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 931276008792 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 931276008793 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276008794 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276008795 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276008796 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276008797 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276008798 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931276008799 MarR family; Region: MarR_2; pfam12802 931276008800 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 931276008801 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931276008802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276008803 S-adenosylmethionine binding site [chemical binding]; other site 931276008804 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 931276008805 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931276008806 active site 931276008807 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276008808 beta-galactosidase; Region: BGL; TIGR03356 931276008809 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 931276008810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276008811 NAD(P) binding site [chemical binding]; other site 931276008812 active site 931276008813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276008814 PAS domain; Region: PAS_9; pfam13426 931276008815 putative active site [active] 931276008816 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 931276008817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276008818 Walker A motif; other site 931276008819 ATP binding site [chemical binding]; other site 931276008820 Walker B motif; other site 931276008821 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 931276008822 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 931276008823 putative active site [active] 931276008824 YdjC motif; other site 931276008825 Mg binding site [ion binding]; other site 931276008826 putative homodimer interface [polypeptide binding]; other site 931276008827 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276008828 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276008829 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 931276008830 CHAT domain; Region: CHAT; cl17868 931276008831 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276008832 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276008833 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276008834 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276008835 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276008836 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 931276008837 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 931276008838 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 931276008839 HTH domain; Region: HTH_11; pfam08279 931276008840 HTH domain; Region: HTH_11; pfam08279 931276008841 PRD domain; Region: PRD; pfam00874 931276008842 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 931276008843 active site 931276008844 P-loop; other site 931276008845 phosphorylation site [posttranslational modification] 931276008846 putative oxidoreductase; Provisional; Region: PRK10206 931276008847 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276008848 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276008849 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 931276008850 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276008851 active site 931276008852 dimer interface [polypeptide binding]; other site 931276008853 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276008854 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276008855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931276008856 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 931276008857 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276008858 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276008859 metal binding site [ion binding]; metal-binding site 931276008860 active site 931276008861 I-site; other site 931276008862 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 931276008863 propionate/acetate kinase; Provisional; Region: PRK12379 931276008864 DNA polymerase III PolC; Validated; Region: polC; PRK00448 931276008865 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 931276008866 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 931276008867 generic binding surface II; other site 931276008868 generic binding surface I; other site 931276008869 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931276008870 active site 931276008871 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 931276008872 active site 931276008873 catalytic site [active] 931276008874 substrate binding site [chemical binding]; other site 931276008875 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 931276008876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276008877 MarR family; Region: MarR_2; pfam12802 931276008878 Predicted membrane protein [Function unknown]; Region: COG1289 931276008879 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 931276008880 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 931276008881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276008882 putative substrate translocation pore; other site 931276008883 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276008884 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 931276008885 ligand binding site [chemical binding]; other site 931276008886 flexible hinge region; other site 931276008887 putative switch regulator; other site 931276008888 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 931276008889 non-specific DNA interactions [nucleotide binding]; other site 931276008890 DNA binding site [nucleotide binding] 931276008891 sequence specific DNA binding site [nucleotide binding]; other site 931276008892 putative cAMP binding site [chemical binding]; other site 931276008893 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 931276008894 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276008895 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 931276008896 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 931276008897 FAD binding pocket [chemical binding]; other site 931276008898 FAD binding motif [chemical binding]; other site 931276008899 phosphate binding motif [ion binding]; other site 931276008900 beta-alpha-beta structure motif; other site 931276008901 NAD binding pocket [chemical binding]; other site 931276008902 Iron coordination center [ion binding]; other site 931276008903 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 931276008904 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931276008905 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276008906 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 931276008907 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 931276008908 [4Fe-4S] binding site [ion binding]; other site 931276008909 molybdopterin cofactor binding site; other site 931276008910 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 931276008911 molybdopterin cofactor binding site; other site 931276008912 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 931276008913 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276008914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931276008915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276008916 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 931276008917 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 931276008918 GTP binding site; other site 931276008919 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 931276008920 putative MPT binding site; other site 931276008921 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 931276008922 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 931276008923 dimer interface [polypeptide binding]; other site 931276008924 putative functional site; other site 931276008925 putative MPT binding site; other site 931276008926 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 931276008927 trimer interface [polypeptide binding]; other site 931276008928 dimer interface [polypeptide binding]; other site 931276008929 putative active site [active] 931276008930 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 931276008931 Walker A motif; other site 931276008932 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 931276008933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276008934 FeS/SAM binding site; other site 931276008935 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 931276008936 MOSC domain; Region: MOSC; pfam03473 931276008937 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 931276008938 MPT binding site; other site 931276008939 trimer interface [polypeptide binding]; other site 931276008940 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931276008941 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 931276008942 active site 931276008943 catalytic tetrad [active] 931276008944 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 931276008945 cobalt transport protein CbiM; Provisional; Region: PRK07331 931276008946 cobalt transport protein CbiM; Provisional; Region: PRK11909 931276008947 PDGLE domain; Region: PDGLE; pfam13190 931276008948 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 931276008949 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931276008950 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931276008951 Walker A/P-loop; other site 931276008952 ATP binding site [chemical binding]; other site 931276008953 Q-loop/lid; other site 931276008954 ABC transporter signature motif; other site 931276008955 Walker B; other site 931276008956 D-loop; other site 931276008957 H-loop/switch region; other site 931276008958 Protein of unknown function DUF111; Region: DUF111; pfam01969 931276008959 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 931276008960 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 931276008961 Ligand Binding Site [chemical binding]; other site 931276008962 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 931276008963 AIR carboxylase; Region: AIRC; smart01001 931276008964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276008965 active site 931276008966 ribonuclease Z; Reviewed; Region: PRK00055 931276008967 Acyltransferase family; Region: Acyl_transf_3; pfam01757 931276008968 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 931276008969 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276008970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276008971 ABC transporter; Region: ABC_tran_2; pfam12848 931276008972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276008973 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 931276008974 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 931276008975 putative acyl-acceptor binding pocket; other site 931276008976 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 931276008977 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 931276008978 G1 box; other site 931276008979 putative GEF interaction site [polypeptide binding]; other site 931276008980 GTP/Mg2+ binding site [chemical binding]; other site 931276008981 Switch I region; other site 931276008982 G2 box; other site 931276008983 G3 box; other site 931276008984 Switch II region; other site 931276008985 G4 box; other site 931276008986 G5 box; other site 931276008987 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 931276008988 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 931276008989 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 931276008990 Protein of unknown function DUF45; Region: DUF45; pfam01863 931276008991 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931276008992 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 931276008993 ligand binding site [chemical binding]; other site 931276008994 Cache domain; Region: Cache_1; pfam02743 931276008995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 931276008996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931276008997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276008998 putative active site [active] 931276008999 heme pocket [chemical binding]; other site 931276009000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276009001 dimer interface [polypeptide binding]; other site 931276009002 phosphorylation site [posttranslational modification] 931276009003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276009004 ATP binding site [chemical binding]; other site 931276009005 Mg2+ binding site [ion binding]; other site 931276009006 G-X-G motif; other site 931276009007 Protein of unknown function, DUF606; Region: DUF606; pfam04657 931276009008 Protein of unknown function, DUF606; Region: DUF606; pfam04657 931276009009 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 931276009010 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276009011 ligand binding site [chemical binding]; other site 931276009012 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 931276009013 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 931276009014 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 931276009015 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 931276009016 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 931276009017 FAD binding pocket [chemical binding]; other site 931276009018 FAD binding motif [chemical binding]; other site 931276009019 phosphate binding motif [ion binding]; other site 931276009020 beta-alpha-beta structure motif; other site 931276009021 NAD binding pocket [chemical binding]; other site 931276009022 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 931276009023 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 931276009024 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 931276009025 DEAD-like helicases superfamily; Region: DEXDc; smart00487 931276009026 ATP binding site [chemical binding]; other site 931276009027 Mg++ binding site [ion binding]; other site 931276009028 motif III; other site 931276009029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276009030 nucleotide binding region [chemical binding]; other site 931276009031 ATP-binding site [chemical binding]; other site 931276009032 Predicted transcriptional regulator [Transcription]; Region: COG1959 931276009033 Transcriptional regulator; Region: Rrf2; pfam02082 931276009034 anthranilate synthase component I; Provisional; Region: PRK13570 931276009035 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 931276009036 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 931276009037 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 931276009038 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 931276009039 glutamine binding [chemical binding]; other site 931276009040 catalytic triad [active] 931276009041 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 931276009042 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 931276009043 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 931276009044 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 931276009045 active site 931276009046 ribulose/triose binding site [chemical binding]; other site 931276009047 phosphate binding site [ion binding]; other site 931276009048 substrate (anthranilate) binding pocket [chemical binding]; other site 931276009049 product (indole) binding pocket [chemical binding]; other site 931276009050 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 931276009051 active site 931276009052 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 931276009053 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 931276009054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276009055 catalytic residue [active] 931276009056 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 931276009057 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 931276009058 substrate binding site [chemical binding]; other site 931276009059 active site 931276009060 catalytic residues [active] 931276009061 heterodimer interface [polypeptide binding]; other site 931276009062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276009063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276009064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276009065 dimerization interface [polypeptide binding]; other site 931276009066 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 931276009067 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 931276009068 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 931276009069 Integral membrane protein DUF95; Region: DUF95; cl00572 931276009070 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276009071 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 931276009072 active site 931276009073 DNA binding site [nucleotide binding] 931276009074 Int/Topo IB signature motif; other site 931276009075 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 931276009076 putative active site [active] 931276009077 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 931276009078 molybdenum-pterin binding domain; Region: Mop; TIGR00638 931276009079 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 931276009080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276009081 Walker A/P-loop; other site 931276009082 ATP binding site [chemical binding]; other site 931276009083 Q-loop/lid; other site 931276009084 ABC transporter signature motif; other site 931276009085 Walker B; other site 931276009086 D-loop; other site 931276009087 H-loop/switch region; other site 931276009088 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 931276009089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276009090 dimer interface [polypeptide binding]; other site 931276009091 conserved gate region; other site 931276009092 putative PBP binding loops; other site 931276009093 ABC-ATPase subunit interface; other site 931276009094 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 931276009095 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 931276009096 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276009097 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 931276009098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276009099 Walker A/P-loop; other site 931276009100 ATP binding site [chemical binding]; other site 931276009101 Q-loop/lid; other site 931276009102 ABC transporter signature motif; other site 931276009103 Walker B; other site 931276009104 D-loop; other site 931276009105 H-loop/switch region; other site 931276009106 molybdenum-pterin binding domain; Region: Mop; TIGR00638 931276009107 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 931276009108 Helix-turn-helix domain; Region: HTH_17; pfam12728 931276009109 PBP superfamily domain; Region: PBP_like; pfam12727 931276009110 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 931276009111 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 931276009112 nitrogenase iron protein; Region: nifH; TIGR01287 931276009113 Nucleotide-binding sites [chemical binding]; other site 931276009114 Walker A motif; other site 931276009115 Switch I region of nucleotide binding site; other site 931276009116 Fe4S4 binding sites [ion binding]; other site 931276009117 Switch II region of nucleotide binding site; other site 931276009118 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 931276009119 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276009120 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931276009121 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276009122 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276009123 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276009124 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 931276009125 MoFe protein beta/alpha subunit interactions; other site 931276009126 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276009127 Beta subunit P cluster binding residues; other site 931276009128 MoFe protein beta subunit/Fe protein contacts; other site 931276009129 MoFe protein dimer/ dimer interactions; other site 931276009130 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 931276009131 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276009132 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276009133 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276009134 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 931276009135 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 931276009136 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 931276009137 dimer interface [polypeptide binding]; other site 931276009138 [2Fe-2S] cluster binding site [ion binding]; other site 931276009139 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 931276009140 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 931276009141 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 931276009142 Nucleotide-binding sites [chemical binding]; other site 931276009143 Walker A motif; other site 931276009144 nitrogenase iron protein; Region: nifH; TIGR01287 931276009145 Switch I region of nucleotide binding site; other site 931276009146 Fe4S4 binding sites [ion binding]; other site 931276009147 Switch II region of nucleotide binding site; other site 931276009148 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 931276009149 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 931276009150 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 931276009151 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931276009152 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931276009153 HEPN domain; Region: HEPN; cl00824 931276009154 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 931276009155 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276009156 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931276009157 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276009158 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 931276009159 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 931276009160 catalytic triad [active] 931276009161 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 931276009162 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 931276009163 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276009164 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 931276009165 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 931276009166 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 931276009167 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 931276009168 active site 931276009169 catalytic residues [active] 931276009170 metal binding site [ion binding]; metal-binding site 931276009171 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 931276009172 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 931276009173 active site 931276009174 catalytic site [active] 931276009175 substrate binding site [chemical binding]; other site 931276009176 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 931276009177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276009178 ATP binding site [chemical binding]; other site 931276009179 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 931276009180 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 931276009181 dinuclear metal binding motif [ion binding]; other site 931276009182 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 931276009183 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 931276009184 catalytic residues [active] 931276009185 catalytic nucleophile [active] 931276009186 Recombinase; Region: Recombinase; pfam07508 931276009187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276009188 binding surface 931276009189 TPR motif; other site 931276009190 TPR repeat; Region: TPR_11; pfam13414 931276009191 TPR repeat; Region: TPR_11; pfam13414 931276009192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276009193 binding surface 931276009194 TPR motif; other site 931276009195 TPR repeat; Region: TPR_11; pfam13414 931276009196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276009197 binding surface 931276009198 TPR motif; other site 931276009199 TPR repeat; Region: TPR_11; pfam13414 931276009200 TPR repeat; Region: TPR_11; pfam13414 931276009201 Tetratricopeptide repeat; Region: TPR_17; pfam13431 931276009202 NACHT domain; Region: NACHT; pfam05729 931276009203 AAA ATPase domain; Region: AAA_16; pfam13191 931276009204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 931276009205 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 931276009206 DDE domain; Region: DDE_Tnp_IS240; pfam13610 931276009207 Integrase core domain; Region: rve; pfam00665 931276009208 Integrase core domain; Region: rve_3; pfam13683 931276009209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 931276009210 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276009211 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276009212 Domain of unknown function DUF11; Region: DUF11; pfam01345 931276009213 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276009214 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276009215 Domain of unknown function DUF11; Region: DUF11; pfam01345 931276009216 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276009217 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276009218 substrate binding pocket [chemical binding]; other site 931276009219 membrane-bound complex binding site; other site 931276009220 hinge residues; other site 931276009221 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276009222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276009223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931276009224 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276009225 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 931276009226 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276009227 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276009228 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 931276009229 DNA binding residues [nucleotide binding] 931276009230 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276009231 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276009232 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 931276009233 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 931276009234 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 931276009235 active site 931276009236 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 931276009237 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 931276009238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276009239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276009240 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 931276009241 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 931276009242 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 931276009243 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 931276009244 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 931276009245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276009246 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 931276009247 active site 931276009248 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931276009249 Flavodoxin domain; Region: Flavodoxin_5; cl17428 931276009250 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276009251 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276009252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276009253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276009254 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276009255 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276009256 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276009257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276009258 substrate binding pocket [chemical binding]; other site 931276009259 membrane-bound complex binding site; other site 931276009260 hinge residues; other site 931276009261 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 931276009262 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 931276009263 non-specific DNA binding site [nucleotide binding]; other site 931276009264 salt bridge; other site 931276009265 sequence-specific DNA binding site [nucleotide binding]; other site 931276009266 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276009267 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276009268 ligand binding site [chemical binding]; other site 931276009269 calcium binding site [ion binding]; other site 931276009270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931276009271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276009272 Coenzyme A binding pocket [chemical binding]; other site 931276009273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931276009274 Helix-turn-helix domain; Region: HTH_28; pfam13518 931276009275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931276009276 Transposase; Region: HTH_Tnp_1; cl17663 931276009277 Helix-turn-helix domain; Region: HTH_28; pfam13518 931276009278 HTH-like domain; Region: HTH_21; pfam13276 931276009279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 931276009280 Integrase core domain; Region: rve; pfam00665 931276009281 Integrase core domain; Region: rve_2; pfam13333 931276009282 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276009283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276009284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276009285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931276009286 active site 931276009287 metal binding site [ion binding]; metal-binding site 931276009288 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 931276009289 putative active site [active] 931276009290 putative metal binding site [ion binding]; other site 931276009291 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 931276009292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276009293 Coenzyme A binding pocket [chemical binding]; other site 931276009294 YmaF family; Region: YmaF; pfam12788 931276009295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276009296 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276009297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 931276009298 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 931276009299 CotJB protein; Region: CotJB; pfam12652 931276009300 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 931276009301 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 931276009302 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 931276009303 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 931276009304 nudix motif; other site 931276009305 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 931276009306 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 931276009307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276009308 active site 931276009309 Isochorismatase family; Region: Isochorismatase; pfam00857 931276009310 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 931276009311 catalytic triad [active] 931276009312 conserved cis-peptide bond; other site 931276009313 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 931276009314 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 931276009315 active site 931276009316 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276009317 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 931276009318 4Fe-4S binding domain; Region: Fer4; pfam00037 931276009319 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 931276009320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276009321 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 931276009322 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 931276009323 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 931276009324 FAD binding domain; Region: FAD_binding_4; pfam01565 931276009325 Berberine and berberine like; Region: BBE; pfam08031 931276009326 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 931276009327 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276009328 Zn2+ binding site [ion binding]; other site 931276009329 Mg2+ binding site [ion binding]; other site 931276009330 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 931276009331 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276009332 histidinol-phosphatase; Reviewed; Region: PRK08123 931276009333 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 931276009334 active site 931276009335 dimer interface [polypeptide binding]; other site 931276009336 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 931276009337 putative active site [active] 931276009338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276009339 Zn2+ binding site [ion binding]; other site 931276009340 Mg2+ binding site [ion binding]; other site 931276009341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276009342 Zn2+ binding site [ion binding]; other site 931276009343 Mg2+ binding site [ion binding]; other site 931276009344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276009345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276009346 active site 931276009347 phosphorylation site [posttranslational modification] 931276009348 intermolecular recognition site; other site 931276009349 dimerization interface [polypeptide binding]; other site 931276009350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276009351 DNA binding site [nucleotide binding] 931276009352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276009353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276009354 dimer interface [polypeptide binding]; other site 931276009355 phosphorylation site [posttranslational modification] 931276009356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276009357 ATP binding site [chemical binding]; other site 931276009358 Mg2+ binding site [ion binding]; other site 931276009359 G-X-G motif; other site 931276009360 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 931276009361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 931276009362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276009363 putative substrate translocation pore; other site 931276009364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276009365 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 931276009366 Putative amidase domain; Region: Amidase_6; pfam12671 931276009367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276009368 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 931276009369 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 931276009370 Dimer interface [polypeptide binding]; other site 931276009371 anticodon binding site; other site 931276009372 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 931276009373 homodimer interface [polypeptide binding]; other site 931276009374 motif 1; other site 931276009375 motif 2; other site 931276009376 active site 931276009377 motif 3; other site 931276009378 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 931276009379 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 931276009380 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 931276009381 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 931276009382 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 931276009383 GatB domain; Region: GatB_Yqey; smart00845 931276009384 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 931276009385 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 931276009386 putative valine binding site [chemical binding]; other site 931276009387 dimer interface [polypeptide binding]; other site 931276009388 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 931276009389 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931276009390 PYR/PP interface [polypeptide binding]; other site 931276009391 dimer interface [polypeptide binding]; other site 931276009392 TPP binding site [chemical binding]; other site 931276009393 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 931276009394 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 931276009395 TPP-binding site [chemical binding]; other site 931276009396 dimer interface [polypeptide binding]; other site 931276009397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276009398 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276009399 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276009400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276009401 Walker A/P-loop; other site 931276009402 ATP binding site [chemical binding]; other site 931276009403 Q-loop/lid; other site 931276009404 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276009405 ABC transporter signature motif; other site 931276009406 Walker B; other site 931276009407 D-loop; other site 931276009408 ABC transporter; Region: ABC_tran_2; pfam12848 931276009409 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276009410 SWIM zinc finger; Region: SWIM; pfam04434 931276009411 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 931276009412 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 931276009413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276009414 ATP binding site [chemical binding]; other site 931276009415 putative Mg++ binding site [ion binding]; other site 931276009416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276009417 nucleotide binding region [chemical binding]; other site 931276009418 ATP-binding site [chemical binding]; other site 931276009419 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 931276009420 MgtC family; Region: MgtC; pfam02308 931276009421 Uncharacterized conserved protein [Function unknown]; Region: COG5495 931276009422 Rossmann-like domain; Region: Rossmann-like; pfam10727 931276009423 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 931276009424 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 931276009425 oligomerization interface [polypeptide binding]; other site 931276009426 active site 931276009427 metal binding site [ion binding]; metal-binding site 931276009428 Pantoate-beta-alanine ligase; Region: PanC; cd00560 931276009429 pantoate--beta-alanine ligase; Region: panC; TIGR00018 931276009430 active site 931276009431 ATP-binding site [chemical binding]; other site 931276009432 pantoate-binding site; other site 931276009433 HXXH motif; other site 931276009434 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 931276009435 tetramerization interface [polypeptide binding]; other site 931276009436 active site 931276009437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931276009438 Transposase; Region: HTH_Tnp_1; pfam01527 931276009439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276009440 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276009441 active site 931276009442 motif I; other site 931276009443 motif II; other site 931276009444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276009445 motif I; other site 931276009446 motif II; other site 931276009447 Cupin domain; Region: Cupin_2; cl17218 931276009448 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276009449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276009450 MFS/sugar transport protein; Region: MFS_2; pfam13347 931276009451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276009452 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 931276009453 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 931276009454 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 931276009455 Catalytic site [active] 931276009456 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276009457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276009458 Walker A/P-loop; other site 931276009459 ATP binding site [chemical binding]; other site 931276009460 Q-loop/lid; other site 931276009461 ABC transporter signature motif; other site 931276009462 Walker B; other site 931276009463 D-loop; other site 931276009464 H-loop/switch region; other site 931276009465 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 931276009466 Uncharacterized conserved protein [Function unknown]; Region: COG5663 931276009467 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 931276009468 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 931276009469 tetrameric interface [polypeptide binding]; other site 931276009470 activator binding site; other site 931276009471 NADP binding site [chemical binding]; other site 931276009472 substrate binding site [chemical binding]; other site 931276009473 catalytic residues [active] 931276009474 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 931276009475 MutS domain I; Region: MutS_I; pfam01624 931276009476 MutS domain II; Region: MutS_II; pfam05188 931276009477 MutS domain III; Region: MutS_III; pfam05192 931276009478 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 931276009479 Walker A/P-loop; other site 931276009480 ATP binding site [chemical binding]; other site 931276009481 Q-loop/lid; other site 931276009482 ABC transporter signature motif; other site 931276009483 Walker B; other site 931276009484 D-loop; other site 931276009485 H-loop/switch region; other site 931276009486 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 931276009487 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 931276009488 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931276009489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276009490 S-adenosylmethionine binding site [chemical binding]; other site 931276009491 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 931276009492 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 931276009493 ATP binding site [chemical binding]; other site 931276009494 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 931276009495 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 931276009496 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 931276009497 bacterial Hfq-like; Region: Hfq; cd01716 931276009498 hexamer interface [polypeptide binding]; other site 931276009499 Sm1 motif; other site 931276009500 RNA binding site [nucleotide binding]; other site 931276009501 Sm2 motif; other site 931276009502 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 931276009503 Aluminium resistance protein; Region: Alum_res; pfam06838 931276009504 LexA repressor; Validated; Region: PRK00215 931276009505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276009506 putative DNA binding site [nucleotide binding]; other site 931276009507 putative Zn2+ binding site [ion binding]; other site 931276009508 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 931276009509 Catalytic site [active] 931276009510 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 931276009511 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276009512 active site 931276009513 DNA binding site [nucleotide binding] 931276009514 Int/Topo IB signature motif; other site 931276009515 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 931276009516 putative deacylase active site [active] 931276009517 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 931276009518 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 931276009519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276009520 FeS/SAM binding site; other site 931276009521 TRAM domain; Region: TRAM; pfam01938 931276009522 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 931276009523 active site residue [active] 931276009524 MarR family; Region: MarR_2; cl17246 931276009525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276009526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276009527 non-specific DNA binding site [nucleotide binding]; other site 931276009528 salt bridge; other site 931276009529 sequence-specific DNA binding site [nucleotide binding]; other site 931276009530 Chloramphenicol acetyltransferase; Region: CAT; cl02008 931276009531 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276009532 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276009533 ligand binding site [chemical binding]; other site 931276009534 calcium binding site [ion binding]; other site 931276009535 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 931276009536 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276009537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276009538 Flavodoxin domain; Region: Flavodoxin_5; cl17428 931276009539 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276009540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276009541 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 931276009542 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 931276009543 NAD(P) binding site [chemical binding]; other site 931276009544 catalytic residues [active] 931276009545 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 931276009546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276009547 NAD(P) binding site [chemical binding]; other site 931276009548 active site 931276009549 Transposase domain (DUF772); Region: DUF772; pfam05598 931276009550 FtsH Extracellular; Region: FtsH_ext; pfam06480 931276009551 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 931276009552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276009553 Walker A motif; other site 931276009554 ATP binding site [chemical binding]; other site 931276009555 Walker B motif; other site 931276009556 arginine finger; other site 931276009557 Peptidase family M41; Region: Peptidase_M41; pfam01434 931276009558 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931276009559 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 931276009560 short chain dehydrogenase; Validated; Region: PRK06182 931276009561 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 931276009562 NADP binding site [chemical binding]; other site 931276009563 active site 931276009564 steroid binding site; other site 931276009565 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931276009566 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276009567 active site 931276009568 FMN binding site [chemical binding]; other site 931276009569 substrate binding site [chemical binding]; other site 931276009570 putative catalytic residue [active] 931276009571 short chain dehydrogenase; Validated; Region: PRK06182 931276009572 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 931276009573 NADP binding site [chemical binding]; other site 931276009574 active site 931276009575 steroid binding site; other site 931276009576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276009577 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276009578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276009579 dimer interface [polypeptide binding]; other site 931276009580 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276009581 putative CheW interface [polypeptide binding]; other site 931276009582 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276009583 active site 931276009584 P-loop; other site 931276009585 phosphorylation site [posttranslational modification] 931276009586 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276009587 active site 931276009588 methionine cluster; other site 931276009589 phosphorylation site [posttranslational modification] 931276009590 metal binding site [ion binding]; metal-binding site 931276009591 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276009592 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276009593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276009594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276009595 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 931276009596 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 931276009597 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 931276009598 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 931276009599 active site 931276009600 catalytic site [active] 931276009601 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 931276009602 Putative esterase; Region: Esterase; pfam00756 931276009603 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 931276009604 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 931276009605 active site 931276009606 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 931276009607 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 931276009608 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 931276009609 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 931276009610 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 931276009611 substrate binding site [chemical binding]; other site 931276009612 active site 931276009613 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 931276009614 metal binding site [ion binding]; metal-binding site 931276009615 ligand binding site [chemical binding]; other site 931276009616 Protein of unknown function (DUF998); Region: DUF998; pfam06197 931276009617 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276009618 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931276009619 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 931276009620 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 931276009621 Presynaptic Site I dimer interface [polypeptide binding]; other site 931276009622 catalytic residues [active] 931276009623 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 931276009624 Synaptic Flat tetramer interface [polypeptide binding]; other site 931276009625 Synaptic Site I dimer interface [polypeptide binding]; other site 931276009626 DNA binding site [nucleotide binding] 931276009627 Recombinase; Region: Recombinase; pfam07508 931276009628 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 931276009629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276009630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276009631 Coenzyme A binding pocket [chemical binding]; other site 931276009632 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 931276009633 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931276009634 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 931276009635 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 931276009636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276009637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276009638 active site 931276009639 phosphorylation site [posttranslational modification] 931276009640 intermolecular recognition site; other site 931276009641 dimerization interface [polypeptide binding]; other site 931276009642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276009643 DNA binding site [nucleotide binding] 931276009644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276009645 dimer interface [polypeptide binding]; other site 931276009646 phosphorylation site [posttranslational modification] 931276009647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276009648 ATP binding site [chemical binding]; other site 931276009649 Mg2+ binding site [ion binding]; other site 931276009650 G-X-G motif; other site 931276009651 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 931276009652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276009653 Walker A motif; other site 931276009654 ATP binding site [chemical binding]; other site 931276009655 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 931276009656 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 931276009657 dimer interface [polypeptide binding]; other site 931276009658 ADP-ribose binding site [chemical binding]; other site 931276009659 active site 931276009660 nudix motif; other site 931276009661 metal binding site [ion binding]; metal-binding site 931276009662 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 931276009663 LytB protein; Region: LYTB; cl00507 931276009664 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 931276009665 RNA binding site [nucleotide binding]; other site 931276009666 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 931276009667 RNA binding site [nucleotide binding]; other site 931276009668 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 931276009669 RNA binding site [nucleotide binding]; other site 931276009670 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 931276009671 RNA binding site [nucleotide binding]; other site 931276009672 cytidylate kinase; Provisional; Region: cmk; PRK00023 931276009673 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 931276009674 CMP-binding site; other site 931276009675 The sites determining sugar specificity; other site 931276009676 HI0933-like protein; Region: HI0933_like; pfam03486 931276009677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276009678 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 931276009679 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 931276009680 Ligand Binding Site [chemical binding]; other site 931276009681 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 931276009682 GTP cyclohydrolase I; Provisional; Region: PLN03044 931276009683 active site 931276009684 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 931276009685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276009686 FeS/SAM binding site; other site 931276009687 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 931276009688 active site 931276009689 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 931276009690 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 931276009691 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931276009692 catalytic loop [active] 931276009693 iron binding site [ion binding]; other site 931276009694 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 931276009695 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931276009696 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931276009697 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 931276009698 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 931276009699 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 931276009700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276009701 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 931276009702 dimer interface [polypeptide binding]; other site 931276009703 catalytic triad [active] 931276009704 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 931276009705 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 931276009706 active site 931276009707 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 931276009708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276009709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276009710 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931276009711 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 931276009712 active site residue [active] 931276009713 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 931276009714 CPxP motif; other site 931276009715 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 931276009716 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 931276009717 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931276009718 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 931276009719 intersubunit interface [polypeptide binding]; other site 931276009720 active site 931276009721 zinc binding site [ion binding]; other site 931276009722 Na+ binding site [ion binding]; other site 931276009723 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 931276009724 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931276009725 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 931276009726 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 931276009727 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931276009728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 931276009729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276009730 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 931276009731 dimer interface [polypeptide binding]; other site 931276009732 active site 931276009733 metal binding site [ion binding]; metal-binding site 931276009734 glutathione binding site [chemical binding]; other site 931276009735 calcium/proton exchanger (cax); Region: cax; TIGR00378 931276009736 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 931276009737 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 931276009738 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826 931276009739 Cl binding site [ion binding]; other site 931276009740 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 931276009741 oligomer interface [polypeptide binding]; other site 931276009742 Late competence development protein ComFB; Region: ComFB; pfam10719 931276009743 short chain dehydrogenase; Provisional; Region: PRK06701 931276009744 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 931276009745 NAD binding site [chemical binding]; other site 931276009746 metal binding site [ion binding]; metal-binding site 931276009747 active site 931276009748 EDD domain protein, DegV family; Region: DegV; TIGR00762 931276009749 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931276009750 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931276009751 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931276009752 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 931276009753 active site 931276009754 catalytic triad [active] 931276009755 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 931276009756 active site 931276009757 catalytic triad [active] 931276009758 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 931276009759 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 931276009760 dimer interface [polypeptide binding]; other site 931276009761 PYR/PP interface [polypeptide binding]; other site 931276009762 TPP binding site [chemical binding]; other site 931276009763 substrate binding site [chemical binding]; other site 931276009764 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 931276009765 Domain of unknown function; Region: EKR; smart00890 931276009766 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931276009767 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 931276009768 TPP-binding site [chemical binding]; other site 931276009769 dimer interface [polypeptide binding]; other site 931276009770 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 931276009771 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 931276009772 trimerization site [polypeptide binding]; other site 931276009773 active site 931276009774 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 931276009775 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 931276009776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276009777 catalytic residue [active] 931276009778 FeS assembly protein SufD; Region: sufD; TIGR01981 931276009779 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 931276009780 FeS assembly protein SufB; Region: sufB; TIGR01980 931276009781 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 931276009782 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 931276009783 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 931276009784 Walker A/P-loop; other site 931276009785 ATP binding site [chemical binding]; other site 931276009786 Q-loop/lid; other site 931276009787 ABC transporter signature motif; other site 931276009788 Walker B; other site 931276009789 D-loop; other site 931276009790 H-loop/switch region; other site 931276009791 Transcriptional regulator; Region: Rrf2; cl17282 931276009792 Rrf2 family protein; Region: rrf2_super; TIGR00738 931276009793 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 931276009794 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931276009795 active site 931276009796 phosphorylation site [posttranslational modification] 931276009797 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 931276009798 active site 931276009799 P-loop; other site 931276009800 phosphorylation site [posttranslational modification] 931276009801 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 931276009802 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 931276009803 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 931276009804 putative substrate binding site [chemical binding]; other site 931276009805 putative ATP binding site [chemical binding]; other site 931276009806 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931276009807 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 931276009808 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931276009809 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 931276009810 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 931276009811 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276009812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276009813 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 931276009814 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 931276009815 galactarate dehydratase; Region: galactar-dH20; TIGR03248 931276009816 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 931276009817 altronate oxidoreductase; Provisional; Region: PRK03643 931276009818 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 931276009819 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 931276009820 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 931276009821 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 931276009822 active site 931276009823 intersubunit interface [polypeptide binding]; other site 931276009824 catalytic residue [active] 931276009825 Glucuronate isomerase; Region: UxaC; pfam02614 931276009826 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 931276009827 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 931276009828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276009829 putative substrate translocation pore; other site 931276009830 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 931276009831 nucleotide binding site/active site [active] 931276009832 HIT family signature motif; other site 931276009833 catalytic residue [active] 931276009834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276009835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276009836 DNA binding site [nucleotide binding] 931276009837 domain linker motif; other site 931276009838 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276009839 dimerization interface [polypeptide binding]; other site 931276009840 ligand binding site [chemical binding]; other site 931276009841 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 931276009842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276009843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276009844 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 931276009845 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 931276009846 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 931276009847 FAD binding site [chemical binding]; other site 931276009848 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 931276009849 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 931276009850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276009851 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 931276009852 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 931276009853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276009854 ATP binding site [chemical binding]; other site 931276009855 putative Mg++ binding site [ion binding]; other site 931276009856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276009857 nucleotide binding region [chemical binding]; other site 931276009858 ATP-binding site [chemical binding]; other site 931276009859 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 931276009860 HRDC domain; Region: HRDC; pfam00570 931276009861 HRDC domain; Region: HRDC; pfam00570 931276009862 methionine aminopeptidase; Provisional; Region: PRK12318 931276009863 SEC-C motif; Region: SEC-C; pfam02810 931276009864 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 931276009865 active site 931276009866 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 931276009867 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 931276009868 ATP binding site [chemical binding]; other site 931276009869 Mg++ binding site [ion binding]; other site 931276009870 motif III; other site 931276009871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276009872 nucleotide binding region [chemical binding]; other site 931276009873 ATP-binding site [chemical binding]; other site 931276009874 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 931276009875 RNA binding site [nucleotide binding]; other site 931276009876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931276009877 DEAD-like helicases superfamily; Region: DEXDc; smart00487 931276009878 ATP binding site [chemical binding]; other site 931276009879 putative Mg++ binding site [ion binding]; other site 931276009880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276009881 nucleotide binding region [chemical binding]; other site 931276009882 ATP-binding site [chemical binding]; other site 931276009883 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931276009884 EamA-like transporter family; Region: EamA; pfam00892 931276009885 EamA-like transporter family; Region: EamA; pfam00892 931276009886 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276009887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276009888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276009889 Walker A/P-loop; other site 931276009890 ATP binding site [chemical binding]; other site 931276009891 Q-loop/lid; other site 931276009892 ABC transporter signature motif; other site 931276009893 Walker B; other site 931276009894 D-loop; other site 931276009895 H-loop/switch region; other site 931276009896 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276009897 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276009898 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 931276009899 Walker A/P-loop; other site 931276009900 ATP binding site [chemical binding]; other site 931276009901 Q-loop/lid; other site 931276009902 ABC transporter signature motif; other site 931276009903 Walker B; other site 931276009904 D-loop; other site 931276009905 H-loop/switch region; other site 931276009906 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 931276009907 Predicted permeases [General function prediction only]; Region: COG0701 931276009908 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276009909 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 931276009910 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276009911 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 931276009912 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276009913 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276009914 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 931276009915 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 931276009916 putative oligomer interface [polypeptide binding]; other site 931276009917 putative active site [active] 931276009918 metal binding site [ion binding]; metal-binding site 931276009919 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 931276009920 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 931276009921 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276009922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276009923 homodimer interface [polypeptide binding]; other site 931276009924 catalytic residue [active] 931276009925 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 931276009926 Mor transcription activator family; Region: Mor; cl02360 931276009927 2-isopropylmalate synthase; Validated; Region: PRK03739 931276009928 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 931276009929 active site 931276009930 catalytic residues [active] 931276009931 metal binding site [ion binding]; metal-binding site 931276009932 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 931276009933 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 931276009934 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276009935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276009936 FtsX-like permease family; Region: FtsX; pfam02687 931276009937 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931276009938 FtsX-like permease family; Region: FtsX; pfam02687 931276009939 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276009940 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276009941 Walker A/P-loop; other site 931276009942 ATP binding site [chemical binding]; other site 931276009943 Q-loop/lid; other site 931276009944 ABC transporter signature motif; other site 931276009945 Walker B; other site 931276009946 D-loop; other site 931276009947 H-loop/switch region; other site 931276009948 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 931276009949 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276009950 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 931276009951 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 931276009952 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276009953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276009954 active site 931276009955 phosphorylation site [posttranslational modification] 931276009956 intermolecular recognition site; other site 931276009957 dimerization interface [polypeptide binding]; other site 931276009958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276009959 DNA binding site [nucleotide binding] 931276009960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276009961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276009962 dimerization interface [polypeptide binding]; other site 931276009963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276009964 dimer interface [polypeptide binding]; other site 931276009965 phosphorylation site [posttranslational modification] 931276009966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276009967 ATP binding site [chemical binding]; other site 931276009968 Mg2+ binding site [ion binding]; other site 931276009969 G-X-G motif; other site 931276009970 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 931276009971 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 931276009972 active site 931276009973 Uncharacterized conserved protein [Function unknown]; Region: COG1434 931276009974 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 931276009975 putative active site [active] 931276009976 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 931276009977 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 931276009978 dimerization interface [polypeptide binding]; other site 931276009979 domain crossover interface; other site 931276009980 redox-dependent activation switch; other site 931276009981 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276009982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276009983 S-adenosylmethionine binding site [chemical binding]; other site 931276009984 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 931276009985 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 931276009986 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 931276009987 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 931276009988 dihydrodipicolinate synthase; Region: dapA; TIGR00674 931276009989 dimer interface [polypeptide binding]; other site 931276009990 active site 931276009991 catalytic residue [active] 931276009992 dihydrodipicolinate reductase; Provisional; Region: PRK00048 931276009993 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 931276009994 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 931276009995 topology modulation protein; Reviewed; Region: PRK08118 931276009996 AAA domain; Region: AAA_17; pfam13207 931276009997 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276009998 Coenzyme A binding pocket [chemical binding]; other site 931276009999 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931276010000 active site 931276010001 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276010002 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931276010003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276010004 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276010005 DNA binding residues [nucleotide binding] 931276010006 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 931276010007 hypothetical protein; Validated; Region: PRK06217 931276010008 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 931276010009 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 931276010010 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276010011 active site 931276010012 dimer interface [polypeptide binding]; other site 931276010013 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 931276010014 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 931276010015 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 931276010016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276010017 motif II; other site 931276010018 H+ Antiporter protein; Region: 2A0121; TIGR00900 931276010019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276010020 putative substrate translocation pore; other site 931276010021 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 931276010022 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931276010023 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 931276010024 putative dimer interface [polypeptide binding]; other site 931276010025 catalytic triad [active] 931276010026 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276010027 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276010028 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276010029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276010030 Serine hydrolase; Region: Ser_hydrolase; cl17834 931276010031 short chain dehydrogenase; Provisional; Region: PRK06914 931276010032 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 931276010033 NADP binding site [chemical binding]; other site 931276010034 active site 931276010035 steroid binding site; other site 931276010036 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931276010037 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276010038 ligand binding site [chemical binding]; other site 931276010039 flexible hinge region; other site 931276010040 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931276010041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010042 Coenzyme A binding pocket [chemical binding]; other site 931276010043 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 931276010044 AAA domain; Region: AAA_17; pfam13207 931276010045 AAA domain; Region: AAA_18; pfam13238 931276010046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010047 Coenzyme A binding pocket [chemical binding]; other site 931276010048 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 931276010049 active site 931276010050 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276010051 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 931276010052 catalytic site [active] 931276010053 TAP-like protein; Region: Abhydrolase_4; pfam08386 931276010054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276010055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010056 Coenzyme A binding pocket [chemical binding]; other site 931276010057 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 931276010058 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931276010059 active site 931276010060 catalytic tetrad [active] 931276010061 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010062 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010063 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010064 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010065 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010066 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010067 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010068 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010069 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 931276010070 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 931276010071 FMN binding site [chemical binding]; other site 931276010072 active site 931276010073 catalytic residues [active] 931276010074 substrate binding site [chemical binding]; other site 931276010075 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 931276010076 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 931276010077 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 931276010078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276010079 FeS/SAM binding site; other site 931276010080 HemN C-terminal domain; Region: HemN_C; pfam06969 931276010081 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 931276010082 nudix motif; other site 931276010083 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276010084 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 931276010085 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 931276010086 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 931276010087 Uncharacterized conserved protein [Function unknown]; Region: COG5646 931276010088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276010089 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276010090 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 931276010091 active site 931276010092 catalytic residues [active] 931276010093 metal binding site [ion binding]; metal-binding site 931276010094 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931276010095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276010096 S-adenosylmethionine binding site [chemical binding]; other site 931276010097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276010098 Zn2+ binding site [ion binding]; other site 931276010099 Mg2+ binding site [ion binding]; other site 931276010100 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276010101 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276010102 Metal-binding active site; metal-binding site 931276010103 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 931276010104 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 931276010105 aspartate racemase; Region: asp_race; TIGR00035 931276010106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 931276010107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276010108 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276010109 Coenzyme A binding pocket [chemical binding]; other site 931276010110 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 931276010111 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 931276010112 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 931276010113 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276010114 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 931276010115 Phosphotransferase enzyme family; Region: APH; pfam01636 931276010116 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 931276010117 active site 931276010118 ATP binding site [chemical binding]; other site 931276010119 substrate binding site [chemical binding]; other site 931276010120 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276010121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 931276010122 active site 931276010123 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276010124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010125 Coenzyme A binding pocket [chemical binding]; other site 931276010126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276010127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276010128 Coenzyme A binding pocket [chemical binding]; other site 931276010129 Beta-lactamase; Region: Beta-lactamase; pfam00144 931276010130 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931276010131 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 931276010132 catalytic triad [active] 931276010133 active site nucleophile [active] 931276010134 Rrf2 family protein; Region: rrf2_super; TIGR00738 931276010135 Transcriptional regulator; Region: Rrf2; pfam02082 931276010136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276010137 S-adenosylmethionine binding site [chemical binding]; other site 931276010138 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276010139 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 931276010140 Phosphotransferase enzyme family; Region: APH; pfam01636 931276010141 active site 931276010142 substrate binding site [chemical binding]; other site 931276010143 ATP binding site [chemical binding]; other site 931276010144 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 931276010145 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 931276010146 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 931276010147 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 931276010148 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 931276010149 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276010150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276010151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931276010152 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 931276010153 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276010154 DNA binding residues [nucleotide binding] 931276010155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010156 Coenzyme A binding pocket [chemical binding]; other site 931276010157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 931276010158 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 931276010159 Cupin domain; Region: Cupin_2; pfam07883 931276010160 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276010161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276010162 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 931276010163 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931276010164 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931276010165 putative active site [active] 931276010166 putative NTP binding site [chemical binding]; other site 931276010167 putative nucleic acid binding site [nucleotide binding]; other site 931276010168 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931276010169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276010170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276010171 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 931276010172 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 931276010173 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 931276010174 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 931276010175 SdpI/YhfL protein family; Region: SdpI; pfam13630 931276010176 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276010177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276010178 S-adenosylmethionine binding site [chemical binding]; other site 931276010179 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 931276010180 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276010181 active site 931276010182 DNA binding site [nucleotide binding] 931276010183 Int/Topo IB signature motif; other site 931276010184 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 931276010185 Putative transposase; Region: Y2_Tnp; pfam04986 931276010186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276010187 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 931276010188 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 931276010189 flagellar capping protein; Reviewed; Region: fliD; PRK08032 931276010190 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 931276010191 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 931276010192 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 931276010193 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 931276010194 dimer interface [polypeptide binding]; other site 931276010195 PYR/PP interface [polypeptide binding]; other site 931276010196 TPP binding site [chemical binding]; other site 931276010197 substrate binding site [chemical binding]; other site 931276010198 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 931276010199 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 931276010200 TPP-binding site [chemical binding]; other site 931276010201 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 931276010202 Helix-turn-helix domain; Region: HTH_18; pfam12833 931276010203 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931276010204 catalytic residues [active] 931276010205 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 931276010206 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 931276010207 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276010208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276010209 homodimer interface [polypeptide binding]; other site 931276010210 catalytic residue [active] 931276010211 aminotransferase A; Validated; Region: PRK07683 931276010212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276010213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276010214 homodimer interface [polypeptide binding]; other site 931276010215 catalytic residue [active] 931276010216 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 931276010217 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 931276010218 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 931276010219 active site 931276010220 trimer interface [polypeptide binding]; other site 931276010221 substrate binding site [chemical binding]; other site 931276010222 CoA binding site [chemical binding]; other site 931276010223 single-stranded DNA-binding protein; Provisional; Region: PRK05813 931276010224 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 931276010225 dimer interface [polypeptide binding]; other site 931276010226 ssDNA binding site [nucleotide binding]; other site 931276010227 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276010228 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 931276010229 NodB motif; other site 931276010230 active site 931276010231 catalytic site [active] 931276010232 metal binding site [ion binding]; metal-binding site 931276010233 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 931276010234 Predicted transcriptional regulator [Transcription]; Region: COG3432 931276010235 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 931276010236 TSCPD domain; Region: TSCPD; cl14834 931276010237 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 931276010238 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 931276010239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931276010240 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931276010241 aspartate aminotransferase; Provisional; Region: PRK06836 931276010242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276010243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276010244 homodimer interface [polypeptide binding]; other site 931276010245 catalytic residue [active] 931276010246 Integral membrane protein TerC family; Region: TerC; cl10468 931276010247 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 931276010248 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276010249 active site 931276010250 HIGH motif; other site 931276010251 nucleotide binding site [chemical binding]; other site 931276010252 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 931276010253 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 931276010254 active site 931276010255 KMSKS motif; other site 931276010256 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 931276010257 tRNA binding surface [nucleotide binding]; other site 931276010258 anticodon binding site; other site 931276010259 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 931276010260 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 931276010261 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276010262 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276010263 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276010264 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276010265 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 931276010266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276010267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276010268 homodimer interface [polypeptide binding]; other site 931276010269 catalytic residue [active] 931276010270 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 931276010271 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 931276010272 Dimer interface [polypeptide binding]; other site 931276010273 anticodon binding site; other site 931276010274 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 931276010275 homodimer interface [polypeptide binding]; other site 931276010276 motif 1; other site 931276010277 motif 2; other site 931276010278 active site 931276010279 motif 3; other site 931276010280 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 931276010281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931276010282 putative metal binding site [ion binding]; other site 931276010283 Membrane protein of unknown function; Region: DUF360; pfam04020 931276010284 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 931276010285 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276010286 putative active site [active] 931276010287 putative metal binding site [ion binding]; other site 931276010288 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 931276010289 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 931276010290 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 931276010291 SLBB domain; Region: SLBB; pfam10531 931276010292 4Fe-4S binding domain; Region: Fer4; pfam00037 931276010293 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931276010294 4Fe-4S binding domain; Region: Fer4; pfam00037 931276010295 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931276010296 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 931276010297 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931276010298 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 931276010299 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931276010300 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 931276010301 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 931276010302 Walker A/P-loop; other site 931276010303 ATP binding site [chemical binding]; other site 931276010304 Q-loop/lid; other site 931276010305 ABC transporter signature motif; other site 931276010306 Walker B; other site 931276010307 D-loop; other site 931276010308 H-loop/switch region; other site 931276010309 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 931276010310 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 931276010311 Walker A/P-loop; other site 931276010312 ATP binding site [chemical binding]; other site 931276010313 Q-loop/lid; other site 931276010314 ABC transporter signature motif; other site 931276010315 Walker B; other site 931276010316 D-loop; other site 931276010317 H-loop/switch region; other site 931276010318 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 931276010319 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 931276010320 TM-ABC transporter signature motif; other site 931276010321 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276010322 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 931276010323 TM-ABC transporter signature motif; other site 931276010324 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931276010325 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 931276010326 putative ligand binding site [chemical binding]; other site 931276010327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276010328 binding surface 931276010329 TPR motif; other site 931276010330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276010331 TPR repeat; Region: TPR_11; pfam13414 931276010332 TPR motif; other site 931276010333 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 931276010334 Sulfatase; Region: Sulfatase; cl17466 931276010335 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 931276010336 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 931276010337 oligomer interface [polypeptide binding]; other site 931276010338 metal binding site [ion binding]; metal-binding site 931276010339 metal binding site [ion binding]; metal-binding site 931276010340 putative Cl binding site [ion binding]; other site 931276010341 aspartate ring; other site 931276010342 basic sphincter; other site 931276010343 hydrophobic gate; other site 931276010344 periplasmic entrance; other site 931276010345 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 931276010346 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 931276010347 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276010348 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931276010349 Walker A/P-loop; other site 931276010350 ATP binding site [chemical binding]; other site 931276010351 Q-loop/lid; other site 931276010352 ABC transporter signature motif; other site 931276010353 Walker B; other site 931276010354 D-loop; other site 931276010355 H-loop/switch region; other site 931276010356 Predicted transcriptional regulators [Transcription]; Region: COG1725 931276010357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276010358 DNA-binding site [nucleotide binding]; DNA binding site 931276010359 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 931276010360 conserved cys residue [active] 931276010361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276010362 Predicted transcriptional regulator [Transcription]; Region: COG2378 931276010363 HTH domain; Region: HTH_11; pfam08279 931276010364 WYL domain; Region: WYL; pfam13280 931276010365 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 931276010366 H+ Antiporter protein; Region: 2A0121; TIGR00900 931276010367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 931276010368 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 931276010369 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276010370 DNA binding residues [nucleotide binding] 931276010371 Methyltransferase domain; Region: Methyltransf_26; pfam13659 931276010372 Predicted membrane protein [Function unknown]; Region: COG2860 931276010373 UPF0126 domain; Region: UPF0126; pfam03458 931276010374 UPF0126 domain; Region: UPF0126; pfam03458 931276010375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276010376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276010377 putative substrate translocation pore; other site 931276010378 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 931276010379 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 931276010380 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 931276010381 dimer interface [polypeptide binding]; other site 931276010382 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276010383 NAD binding site [chemical binding]; other site 931276010384 substrate binding site [chemical binding]; other site 931276010385 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 931276010386 dinuclear metal binding motif [ion binding]; other site 931276010387 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 931276010388 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 931276010389 active site 931276010390 Zn binding site [ion binding]; other site 931276010391 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 931276010392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276010393 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276010394 active site 931276010395 motif I; other site 931276010396 motif II; other site 931276010397 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276010398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276010399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010400 dimerization interface [polypeptide binding]; other site 931276010401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276010402 dimer interface [polypeptide binding]; other site 931276010403 phosphorylation site [posttranslational modification] 931276010404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276010405 ATP binding site [chemical binding]; other site 931276010406 Mg2+ binding site [ion binding]; other site 931276010407 G-X-G motif; other site 931276010408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276010409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276010410 active site 931276010411 phosphorylation site [posttranslational modification] 931276010412 intermolecular recognition site; other site 931276010413 dimerization interface [polypeptide binding]; other site 931276010414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276010415 DNA binding site [nucleotide binding] 931276010416 SdpI/YhfL protein family; Region: SdpI; pfam13630 931276010417 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276010418 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 931276010419 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 931276010420 AAA domain; Region: AAA_17; pfam13207 931276010421 AAA domain; Region: AAA_18; pfam13238 931276010422 CAAX protease self-immunity; Region: Abi; pfam02517 931276010423 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 931276010424 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 931276010425 active site 931276010426 Zn binding site [ion binding]; other site 931276010427 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 931276010428 Part of AAA domain; Region: AAA_19; pfam13245 931276010429 Family description; Region: UvrD_C_2; pfam13538 931276010430 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 931276010431 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 931276010432 dimer interface [polypeptide binding]; other site 931276010433 active site 931276010434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276010435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276010436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276010437 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276010438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276010439 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 931276010440 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931276010441 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 931276010442 Domain of unknown function DUF21; Region: DUF21; pfam01595 931276010443 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 931276010444 Transporter associated domain; Region: CorC_HlyC; smart01091 931276010445 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 931276010446 active site 931276010447 catalytic site [active] 931276010448 substrate binding site [chemical binding]; other site 931276010449 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 931276010450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276010451 active site 931276010452 phosphorylation site [posttranslational modification] 931276010453 intermolecular recognition site; other site 931276010454 dimerization interface [polypeptide binding]; other site 931276010455 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 931276010456 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 931276010457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276010458 putative active site [active] 931276010459 heme pocket [chemical binding]; other site 931276010460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276010461 ATP binding site [chemical binding]; other site 931276010462 Mg2+ binding site [ion binding]; other site 931276010463 G-X-G motif; other site 931276010464 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 931276010465 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 931276010466 Malic enzyme, N-terminal domain; Region: malic; pfam00390 931276010467 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 931276010468 putative NAD(P) binding site [chemical binding]; other site 931276010469 Cache domain; Region: Cache_1; pfam02743 931276010470 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276010471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010472 dimerization interface [polypeptide binding]; other site 931276010473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276010474 dimer interface [polypeptide binding]; other site 931276010475 putative CheW interface [polypeptide binding]; other site 931276010476 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931276010477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276010478 DNA-binding site [nucleotide binding]; DNA binding site 931276010479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276010480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276010481 homodimer interface [polypeptide binding]; other site 931276010482 catalytic residue [active] 931276010483 Response regulator receiver domain; Region: Response_reg; pfam00072 931276010484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276010485 active site 931276010486 phosphorylation site [posttranslational modification] 931276010487 intermolecular recognition site; other site 931276010488 dimerization interface [polypeptide binding]; other site 931276010489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276010490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276010491 dimer interface [polypeptide binding]; other site 931276010492 phosphorylation site [posttranslational modification] 931276010493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276010494 ATP binding site [chemical binding]; other site 931276010495 Mg2+ binding site [ion binding]; other site 931276010496 G-X-G motif; other site 931276010497 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276010498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276010499 active site 931276010500 phosphorylation site [posttranslational modification] 931276010501 intermolecular recognition site; other site 931276010502 dimerization interface [polypeptide binding]; other site 931276010503 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276010504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010505 dimerization interface [polypeptide binding]; other site 931276010506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931276010507 dimerization interface [polypeptide binding]; other site 931276010508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276010509 dimer interface [polypeptide binding]; other site 931276010510 putative CheW interface [polypeptide binding]; other site 931276010511 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276010512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010513 dimerization interface [polypeptide binding]; other site 931276010514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010515 dimerization interface [polypeptide binding]; other site 931276010516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276010517 dimer interface [polypeptide binding]; other site 931276010518 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276010519 putative CheW interface [polypeptide binding]; other site 931276010520 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276010521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010522 dimerization interface [polypeptide binding]; other site 931276010523 PAS domain; Region: PAS; smart00091 931276010524 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276010525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010526 dimerization interface [polypeptide binding]; other site 931276010527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276010528 dimer interface [polypeptide binding]; other site 931276010529 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276010530 putative CheW interface [polypeptide binding]; other site 931276010531 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931276010532 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 931276010533 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931276010534 putative binding surface; other site 931276010535 active site 931276010536 P2 response regulator binding domain; Region: P2; pfam07194 931276010537 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 931276010538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276010539 ATP binding site [chemical binding]; other site 931276010540 Mg2+ binding site [ion binding]; other site 931276010541 G-X-G motif; other site 931276010542 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 931276010543 Response regulator receiver domain; Region: Response_reg; pfam00072 931276010544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276010545 active site 931276010546 phosphorylation site [posttranslational modification] 931276010547 intermolecular recognition site; other site 931276010548 dimerization interface [polypeptide binding]; other site 931276010549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010550 Coenzyme A binding pocket [chemical binding]; other site 931276010551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010552 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276010553 Coenzyme A binding pocket [chemical binding]; other site 931276010554 GTPase RsgA; Reviewed; Region: PRK01889 931276010555 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 931276010556 RNA binding site [nucleotide binding]; other site 931276010557 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 931276010558 GTPase/Zn-binding domain interface [polypeptide binding]; other site 931276010559 GTP/Mg2+ binding site [chemical binding]; other site 931276010560 G4 box; other site 931276010561 G5 box; other site 931276010562 G1 box; other site 931276010563 Switch I region; other site 931276010564 G2 box; other site 931276010565 G3 box; other site 931276010566 Switch II region; other site 931276010567 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 931276010568 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 931276010569 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 931276010570 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 931276010571 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 931276010572 active site 931276010573 SAM binding site [chemical binding]; other site 931276010574 homodimer interface [polypeptide binding]; other site 931276010575 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 931276010576 active site 931276010577 SAM binding site [chemical binding]; other site 931276010578 homodimer interface [polypeptide binding]; other site 931276010579 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 931276010580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276010581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276010582 S-adenosylmethionine binding site [chemical binding]; other site 931276010583 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 931276010584 active site 931276010585 putative homodimer interface [polypeptide binding]; other site 931276010586 SAM binding site [chemical binding]; other site 931276010587 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 931276010588 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 931276010589 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 931276010590 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 931276010591 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 931276010592 catalytic triad [active] 931276010593 hypothetical protein; Provisional; Region: PRK00872 931276010594 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 931276010595 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 931276010596 active site 931276010597 C-terminal domain interface [polypeptide binding]; other site 931276010598 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 931276010599 active site 931276010600 N-terminal domain interface [polypeptide binding]; other site 931276010601 YmaF family; Region: YmaF; pfam12788 931276010602 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276010603 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276010604 Domain of unknown function DUF11; Region: DUF11; cl17728 931276010605 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276010606 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276010607 Domain of unknown function DUF11; Region: DUF11; cl17728 931276010608 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 931276010609 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931276010610 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 931276010611 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931276010612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276010613 DNA-binding site [nucleotide binding]; DNA binding site 931276010614 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276010615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276010616 homodimer interface [polypeptide binding]; other site 931276010617 catalytic residue [active] 931276010618 NACHT domain; Region: NACHT; pfam05729 931276010619 SEFIR domain; Region: SEFIR; pfam08357 931276010620 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931276010621 active site 931276010622 metal binding site [ion binding]; metal-binding site 931276010623 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931276010624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276010625 YvrJ protein family; Region: YvrJ; pfam12841 931276010626 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 931276010627 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 931276010628 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 931276010629 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 931276010630 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 931276010631 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 931276010632 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 931276010633 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 931276010634 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931276010635 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276010636 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 931276010637 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 931276010638 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 931276010639 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 931276010640 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 931276010641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276010642 Walker A motif; other site 931276010643 ATP binding site [chemical binding]; other site 931276010644 Walker B motif; other site 931276010645 arginine finger; other site 931276010646 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 931276010647 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 931276010648 Helix-turn-helix domain; Region: HTH_17; cl17695 931276010649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276010650 non-specific DNA binding site [nucleotide binding]; other site 931276010651 salt bridge; other site 931276010652 sequence-specific DNA binding site [nucleotide binding]; other site 931276010653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 931276010654 non-specific DNA binding site [nucleotide binding]; other site 931276010655 salt bridge; other site 931276010656 sequence-specific DNA binding site [nucleotide binding]; other site 931276010657 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 931276010658 Int/Topo IB signature motif; other site 931276010659 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 931276010660 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 931276010661 cofactor binding site; other site 931276010662 DNA binding site [nucleotide binding] 931276010663 substrate interaction site [chemical binding]; other site 931276010664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276010665 Walker A/P-loop; other site 931276010666 ATP binding site [chemical binding]; other site 931276010667 Q-loop/lid; other site 931276010668 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 931276010669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276010670 Walker A/P-loop; other site 931276010671 ATP binding site [chemical binding]; other site 931276010672 AAA domain; Region: AAA_21; pfam13304 931276010673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 931276010674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 931276010675 active site 931276010676 ATP binding site [chemical binding]; other site 931276010677 substrate binding site [chemical binding]; other site 931276010678 activation loop (A-loop); other site 931276010679 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 931276010680 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 931276010681 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 931276010682 homodimer interface [polypeptide binding]; other site 931276010683 chemical substrate binding site [chemical binding]; other site 931276010684 oligomer interface [polypeptide binding]; other site 931276010685 metal binding site [ion binding]; metal-binding site 931276010686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276010687 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 931276010688 Cupin domain; Region: Cupin_2; cl17218 931276010689 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 931276010690 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276010691 Zn2+ binding site [ion binding]; other site 931276010692 Mg2+ binding site [ion binding]; other site 931276010693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276010694 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276010695 dimerization interface [polypeptide binding]; other site 931276010696 putative DNA binding site [nucleotide binding]; other site 931276010697 putative Zn2+ binding site [ion binding]; other site 931276010698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010699 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276010700 Coenzyme A binding pocket [chemical binding]; other site 931276010701 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 931276010702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276010703 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276010704 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 931276010705 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 931276010706 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 931276010707 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 931276010708 active site 931276010709 Zn binding site [ion binding]; other site 931276010710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010711 Coenzyme A binding pocket [chemical binding]; other site 931276010712 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 931276010713 substrate binding site [chemical binding]; other site 931276010714 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276010715 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276010716 hypothetical protein; Provisional; Region: PRK08262 931276010717 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 931276010718 metal binding site [ion binding]; metal-binding site 931276010719 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 931276010720 aspartate racemase; Region: asp_race; TIGR00035 931276010721 Condensation domain; Region: Condensation; pfam00668 931276010722 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276010723 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 931276010724 acyl-activating enzyme (AAE) consensus motif; other site 931276010725 AMP binding site [chemical binding]; other site 931276010726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276010727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276010728 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 931276010729 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 931276010730 putative catalytic cysteine [active] 931276010731 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 931276010732 putative active site [active] 931276010733 metal binding site [ion binding]; metal-binding site 931276010734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 931276010735 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 931276010736 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 931276010737 dimer interface [polypeptide binding]; other site 931276010738 FMN binding site [chemical binding]; other site 931276010739 Pirin-related protein [General function prediction only]; Region: COG1741 931276010740 Pirin; Region: Pirin; pfam02678 931276010741 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931276010742 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 931276010743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276010744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276010745 WHG domain; Region: WHG; pfam13305 931276010746 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 931276010747 Malic enzyme, N-terminal domain; Region: malic; pfam00390 931276010748 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 931276010749 putative NAD(P) binding site [chemical binding]; other site 931276010750 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 931276010751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276010752 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 931276010753 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 931276010754 active site 931276010755 substrate-binding site [chemical binding]; other site 931276010756 metal-binding site [ion binding] 931276010757 ATP binding site [chemical binding]; other site 931276010758 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 931276010759 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 931276010760 PrpF protein; Region: PrpF; pfam04303 931276010761 aconitate hydratase; Validated; Region: PRK07229 931276010762 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 931276010763 substrate binding site [chemical binding]; other site 931276010764 ligand binding site [chemical binding]; other site 931276010765 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 931276010766 substrate binding site [chemical binding]; other site 931276010767 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 931276010768 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 931276010769 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 931276010770 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 931276010771 citrate lyase subunit gamma; Provisional; Region: PRK13253 931276010772 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 931276010773 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276010774 active site 931276010775 nucleotide binding site [chemical binding]; other site 931276010776 HIGH motif; other site 931276010777 KMSKS motif; other site 931276010778 Transcriptional regulators [Transcription]; Region: GntR; COG1802 931276010779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276010780 DNA-binding site [nucleotide binding]; DNA binding site 931276010781 FCD domain; Region: FCD; pfam07729 931276010782 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 931276010783 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276010784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276010785 dimerization interface [polypeptide binding]; other site 931276010786 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276010787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276010788 dimer interface [polypeptide binding]; other site 931276010789 putative CheW interface [polypeptide binding]; other site 931276010790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276010791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276010792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276010793 dimerization interface [polypeptide binding]; other site 931276010794 acetolactate synthase; Reviewed; Region: PRK08322 931276010795 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931276010796 PYR/PP interface [polypeptide binding]; other site 931276010797 dimer interface [polypeptide binding]; other site 931276010798 TPP binding site [chemical binding]; other site 931276010799 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 931276010800 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 931276010801 TPP-binding site [chemical binding]; other site 931276010802 dimer interface [polypeptide binding]; other site 931276010803 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 931276010804 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276010805 ligand binding site [chemical binding]; other site 931276010806 calcium binding site [ion binding]; other site 931276010807 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 931276010808 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931276010809 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931276010810 putative active site [active] 931276010811 putative NTP binding site [chemical binding]; other site 931276010812 putative nucleic acid binding site [nucleotide binding]; other site 931276010813 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931276010814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931276010815 Helix-turn-helix domain; Region: HTH_28; pfam13518 931276010816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931276010817 Transposase; Region: HTH_Tnp_1; cl17663 931276010818 Helix-turn-helix domain; Region: HTH_28; pfam13518 931276010819 HTH-like domain; Region: HTH_21; pfam13276 931276010820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 931276010821 Integrase core domain; Region: rve; pfam00665 931276010822 Integrase core domain; Region: rve_2; pfam13333 931276010823 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 931276010824 nudix motif; other site 931276010825 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 931276010826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276010827 S-adenosylmethionine binding site [chemical binding]; other site 931276010828 CAAX protease self-immunity; Region: Abi; pfam02517 931276010829 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 931276010830 UbiA prenyltransferase family; Region: UbiA; pfam01040 931276010831 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 931276010832 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276010833 4Fe-4S binding domain; Region: Fer4; pfam00037 931276010834 YtkA-like; Region: YtkA; pfam13115 931276010835 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 931276010836 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 931276010837 substrate binding pocket [chemical binding]; other site 931276010838 chain length determination region; other site 931276010839 substrate-Mg2+ binding site; other site 931276010840 catalytic residues [active] 931276010841 aspartate-rich region 1; other site 931276010842 active site lid residues [active] 931276010843 aspartate-rich region 2; other site 931276010844 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 931276010845 HAMP domain; Region: HAMP; pfam00672 931276010846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276010847 dimer interface [polypeptide binding]; other site 931276010848 phosphorylation site [posttranslational modification] 931276010849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276010850 ATP binding site [chemical binding]; other site 931276010851 Mg2+ binding site [ion binding]; other site 931276010852 G-X-G motif; other site 931276010853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276010854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276010855 active site 931276010856 phosphorylation site [posttranslational modification] 931276010857 intermolecular recognition site; other site 931276010858 dimerization interface [polypeptide binding]; other site 931276010859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276010860 DNA binding site [nucleotide binding] 931276010861 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 931276010862 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276010863 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 931276010864 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276010865 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931276010866 FMN-binding domain; Region: FMN_bind; cl01081 931276010867 FMN-binding domain; Region: FMN_bind; cl01081 931276010868 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 931276010869 ApbE family; Region: ApbE; pfam02424 931276010870 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931276010871 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931276010872 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276010873 MarR family; Region: MarR_2; pfam12802 931276010874 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 931276010875 metal-binding site [ion binding] 931276010876 multicopper oxidase; Provisional; Region: PRK10965 931276010877 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 931276010878 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 931276010879 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931276010880 metal-binding site [ion binding] 931276010881 Uncharacterized conserved protein [Function unknown]; Region: COG2836 931276010882 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 931276010883 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 931276010884 K+ potassium transporter; Region: K_trans; pfam02705 931276010885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276010886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276010887 dimer interface [polypeptide binding]; other site 931276010888 phosphorylation site [posttranslational modification] 931276010889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276010890 ATP binding site [chemical binding]; other site 931276010891 Mg2+ binding site [ion binding]; other site 931276010892 G-X-G motif; other site 931276010893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276010894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276010895 active site 931276010896 phosphorylation site [posttranslational modification] 931276010897 intermolecular recognition site; other site 931276010898 dimerization interface [polypeptide binding]; other site 931276010899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276010900 DNA binding site [nucleotide binding] 931276010901 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 931276010902 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 931276010903 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 931276010904 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 931276010905 Amidohydrolase; Region: Amidohydro_2; pfam04909 931276010906 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 931276010907 Protein export membrane protein; Region: SecD_SecF; cl14618 931276010908 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276010909 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276010910 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276010911 putative membrane fusion protein; Region: TIGR02828 931276010912 Outer membrane efflux protein; Region: OEP; pfam02321 931276010913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276010914 putative acetyltransferase; Provisional; Region: PRK03624 931276010915 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 931276010916 Probable zinc-binding domain; Region: zf-trcl; pfam13451 931276010917 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 931276010918 putative FMN binding site [chemical binding]; other site 931276010919 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931276010920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010921 Coenzyme A binding pocket [chemical binding]; other site 931276010922 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 931276010923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276010924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276010925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931276010926 dimerization interface [polypeptide binding]; other site 931276010927 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 931276010928 active site 931276010929 catalytic residues [active] 931276010930 metal binding site [ion binding]; metal-binding site 931276010931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276010932 non-specific DNA binding site [nucleotide binding]; other site 931276010933 salt bridge; other site 931276010934 sequence-specific DNA binding site [nucleotide binding]; other site 931276010935 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276010936 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276010937 dimer interface [polypeptide binding]; other site 931276010938 putative CheW interface [polypeptide binding]; other site 931276010939 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 931276010940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276010941 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276010942 Coenzyme A binding pocket [chemical binding]; other site 931276010943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276010944 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276010945 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 931276010946 DNA binding site [nucleotide binding] 931276010947 sequence specific DNA binding site [nucleotide binding]; other site 931276010948 putative cAMP binding site [chemical binding]; other site 931276010949 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 931276010950 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276010951 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 931276010952 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276010953 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276010954 4Fe-4S binding domain; Region: Fer4; cl02805 931276010955 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931276010956 4Fe-4S binding domain; Region: Fer4; pfam00037 931276010957 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 931276010958 putative FMN binding site [chemical binding]; other site 931276010959 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 931276010960 Active_site [active] 931276010961 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 931276010962 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 931276010963 active site 931276010964 metal binding site [ion binding]; metal-binding site 931276010965 nudix motif; other site 931276010966 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 931276010967 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276010968 beta-galactosidase; Region: BGL; TIGR03356 931276010969 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 931276010970 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276010971 active site turn [active] 931276010972 phosphorylation site [posttranslational modification] 931276010973 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276010974 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 931276010975 HPr interaction site; other site 931276010976 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276010977 active site 931276010978 phosphorylation site [posttranslational modification] 931276010979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276010980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276010981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276010982 dimerization interface [polypeptide binding]; other site 931276010983 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 931276010984 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 931276010985 G1 box; other site 931276010986 GTP/Mg2+ binding site [chemical binding]; other site 931276010987 Switch I region; other site 931276010988 G2 box; other site 931276010989 Switch II region; other site 931276010990 G3 box; other site 931276010991 G4 box; other site 931276010992 G5 box; other site 931276010993 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 931276010994 Aspartase; Region: Aspartase; cd01357 931276010995 active sites [active] 931276010996 tetramer interface [polypeptide binding]; other site 931276010997 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 931276010998 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276010999 ligand binding site [chemical binding]; other site 931276011000 calcium binding site [ion binding]; other site 931276011001 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 931276011002 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 931276011003 dimer interface [polypeptide binding]; other site 931276011004 active site 931276011005 metal binding site [ion binding]; metal-binding site 931276011006 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 931276011007 intersubunit interface [polypeptide binding]; other site 931276011008 active site 931276011009 Zn2+ binding site [ion binding]; other site 931276011010 L-rhamnose isomerase; Provisional; Region: PRK01076 931276011011 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 931276011012 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 931276011013 N- and C-terminal domain interface [polypeptide binding]; other site 931276011014 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 931276011015 active site 931276011016 putative catalytic site [active] 931276011017 metal binding site [ion binding]; metal-binding site 931276011018 ATP binding site [chemical binding]; other site 931276011019 carbohydrate binding site [chemical binding]; other site 931276011020 Cupin domain; Region: Cupin_2; pfam07883 931276011021 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276011022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276011023 Stage II sporulation protein; Region: SpoIID; pfam08486 931276011024 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 931276011025 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931276011026 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276011027 EamA-like transporter family; Region: EamA; pfam00892 931276011028 EamA-like transporter family; Region: EamA; pfam00892 931276011029 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 931276011030 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931276011031 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931276011032 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276011033 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 931276011034 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 931276011035 intersubunit interface [polypeptide binding]; other site 931276011036 active site 931276011037 Zn2+ binding site [ion binding]; other site 931276011038 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 931276011039 Coenzyme A transferase; Region: CoA_trans; smart00882 931276011040 Coenzyme A transferase; Region: CoA_trans; cl17247 931276011041 YIEGIA protein; Region: YIEGIA; pfam14045 931276011042 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 931276011043 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931276011044 Peptidase family U32; Region: Peptidase_U32; pfam01136 931276011045 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 931276011046 prolyl-tRNA synthetase; Provisional; Region: PRK08661 931276011047 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 931276011048 dimer interface [polypeptide binding]; other site 931276011049 motif 1; other site 931276011050 active site 931276011051 motif 2; other site 931276011052 motif 3; other site 931276011053 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 931276011054 anticodon binding site; other site 931276011055 zinc-binding site [ion binding]; other site 931276011056 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 931276011057 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276011058 active site 931276011059 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276011060 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 931276011061 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 931276011062 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 931276011063 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 931276011064 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 931276011065 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 931276011066 putative NADH binding site [chemical binding]; other site 931276011067 putative active site [active] 931276011068 nudix motif; other site 931276011069 putative metal binding site [ion binding]; other site 931276011070 Uncharacterized conserved protein [Function unknown]; Region: COG2966 931276011071 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 931276011072 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 931276011073 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 931276011074 putative active site [active] 931276011075 putative catalytic site [active] 931276011076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931276011077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276011078 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 931276011079 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276011080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276011081 Walker A/P-loop; other site 931276011082 ATP binding site [chemical binding]; other site 931276011083 Q-loop/lid; other site 931276011084 ABC transporter signature motif; other site 931276011085 Walker B; other site 931276011086 D-loop; other site 931276011087 H-loop/switch region; other site 931276011088 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 931276011089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276011090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276011091 Walker A/P-loop; other site 931276011092 ATP binding site [chemical binding]; other site 931276011093 Q-loop/lid; other site 931276011094 ABC transporter signature motif; other site 931276011095 Walker B; other site 931276011096 D-loop; other site 931276011097 H-loop/switch region; other site 931276011098 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 931276011099 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 931276011100 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 931276011101 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 931276011102 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 931276011103 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 931276011104 substrate binding pocket [chemical binding]; other site 931276011105 chain length determination region; other site 931276011106 substrate-Mg2+ binding site; other site 931276011107 catalytic residues [active] 931276011108 aspartate-rich region 1; other site 931276011109 active site lid residues [active] 931276011110 aspartate-rich region 2; other site 931276011111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276011112 dimer interface [polypeptide binding]; other site 931276011113 putative CheW interface [polypeptide binding]; other site 931276011114 Uncharacterized conserved protein [Function unknown]; Region: COG3287 931276011115 FIST N domain; Region: FIST; pfam08495 931276011116 FIST C domain; Region: FIST_C; pfam10442 931276011117 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 931276011118 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276011119 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931276011120 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931276011121 catalytic loop [active] 931276011122 iron binding site [ion binding]; other site 931276011123 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 931276011124 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 931276011125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276011126 hypothetical protein; Validated; Region: PRK07121 931276011127 L-aspartate oxidase; Provisional; Region: PRK06175 931276011128 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 931276011129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276011130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276011131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276011132 dimerization interface [polypeptide binding]; other site 931276011133 DTW domain; Region: DTW; cl01221 931276011134 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 931276011135 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276011136 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 931276011137 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 931276011138 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 931276011139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276011140 active site 931276011141 motif I; other site 931276011142 motif II; other site 931276011143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276011144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276011145 Coenzyme A binding pocket [chemical binding]; other site 931276011146 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276011147 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276011148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276011149 dimer interface [polypeptide binding]; other site 931276011150 putative CheW interface [polypeptide binding]; other site 931276011151 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 931276011152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276011153 S-ribosylhomocysteinase; Provisional; Region: PRK02260 931276011154 TfoX C-terminal domain; Region: TfoX_C; pfam04994 931276011155 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 931276011156 Uncharacterized conserved protein [Function unknown]; Region: COG2006 931276011157 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 931276011158 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 931276011159 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 931276011160 Hemerythrin; Region: Hemerythrin; cd12107 931276011161 Fe binding site [ion binding]; other site 931276011162 Response regulator receiver domain; Region: Response_reg; pfam00072 931276011163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276011164 active site 931276011165 phosphorylation site [posttranslational modification] 931276011166 intermolecular recognition site; other site 931276011167 dimerization interface [polypeptide binding]; other site 931276011168 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931276011169 GAF domain; Region: GAF_3; pfam13492 931276011170 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 931276011171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276011172 putative active site [active] 931276011173 heme pocket [chemical binding]; other site 931276011174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276011175 dimer interface [polypeptide binding]; other site 931276011176 phosphorylation site [posttranslational modification] 931276011177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276011178 ATP binding site [chemical binding]; other site 931276011179 Mg2+ binding site [ion binding]; other site 931276011180 G-X-G motif; other site 931276011181 Response regulator receiver domain; Region: Response_reg; pfam00072 931276011182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276011183 active site 931276011184 phosphorylation site [posttranslational modification] 931276011185 intermolecular recognition site; other site 931276011186 dimerization interface [polypeptide binding]; other site 931276011187 Response regulator receiver domain; Region: Response_reg; pfam00072 931276011188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276011189 active site 931276011190 phosphorylation site [posttranslational modification] 931276011191 intermolecular recognition site; other site 931276011192 dimerization interface [polypeptide binding]; other site 931276011193 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931276011194 putative binding surface; other site 931276011195 active site 931276011196 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276011197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276011198 Zn2+ binding site [ion binding]; other site 931276011199 Mg2+ binding site [ion binding]; other site 931276011200 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 931276011201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276011202 substrate binding pocket [chemical binding]; other site 931276011203 membrane-bound complex binding site; other site 931276011204 hinge residues; other site 931276011205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276011206 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276011207 Walker A/P-loop; other site 931276011208 ATP binding site [chemical binding]; other site 931276011209 Q-loop/lid; other site 931276011210 ABC transporter signature motif; other site 931276011211 Walker B; other site 931276011212 D-loop; other site 931276011213 H-loop/switch region; other site 931276011214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276011215 dimer interface [polypeptide binding]; other site 931276011216 conserved gate region; other site 931276011217 putative PBP binding loops; other site 931276011218 ABC-ATPase subunit interface; other site 931276011219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276011220 dimer interface [polypeptide binding]; other site 931276011221 conserved gate region; other site 931276011222 putative PBP binding loops; other site 931276011223 ABC-ATPase subunit interface; other site 931276011224 Uncharacterized conserved protein [Function unknown]; Region: COG0397 931276011225 hypothetical protein; Validated; Region: PRK00029 931276011226 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 931276011227 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931276011228 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 931276011229 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276011230 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 931276011231 RNA/DNA hybrid binding site [nucleotide binding]; other site 931276011232 active site 931276011233 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 931276011234 Uncharacterized conserved protein [Function unknown]; Region: COG0398 931276011235 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276011236 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276011237 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276011238 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 931276011239 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931276011240 active site 931276011241 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 931276011242 Integral membrane protein TerC family; Region: TerC; cl10468 931276011243 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276011244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276011245 Zn2+ binding site [ion binding]; other site 931276011246 Mg2+ binding site [ion binding]; other site 931276011247 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 931276011248 YibE/F-like protein; Region: YibE_F; pfam07907 931276011249 YibE/F-like protein; Region: YibE_F; cl02259 931276011250 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276011251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276011252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276011253 Walker A/P-loop; other site 931276011254 ATP binding site [chemical binding]; other site 931276011255 Q-loop/lid; other site 931276011256 ABC transporter signature motif; other site 931276011257 Walker B; other site 931276011258 D-loop; other site 931276011259 H-loop/switch region; other site 931276011260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276011261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276011262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276011263 Walker A/P-loop; other site 931276011264 ATP binding site [chemical binding]; other site 931276011265 Q-loop/lid; other site 931276011266 ABC transporter signature motif; other site 931276011267 Walker B; other site 931276011268 D-loop; other site 931276011269 H-loop/switch region; other site 931276011270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276011271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276011272 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 931276011273 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 931276011274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931276011275 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 931276011276 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 931276011277 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 931276011278 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 931276011279 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 931276011280 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 931276011281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276011282 RNA binding surface [nucleotide binding]; other site 931276011283 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276011284 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 931276011285 EamA-like transporter family; Region: EamA; cl17759 931276011286 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 931276011287 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 931276011288 active site 931276011289 metal binding site [ion binding]; metal-binding site 931276011290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276011291 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 931276011292 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 931276011293 G1 box; other site 931276011294 GTP/Mg2+ binding site [chemical binding]; other site 931276011295 Switch I region; other site 931276011296 G2 box; other site 931276011297 G3 box; other site 931276011298 Switch II region; other site 931276011299 G4 box; other site 931276011300 G5 box; other site 931276011301 Nucleoside recognition; Region: Gate; pfam07670 931276011302 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 931276011303 Nucleoside recognition; Region: Gate; pfam07670 931276011304 FeoA domain; Region: FeoA; cl00838 931276011305 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931276011306 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 931276011307 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276011308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276011309 metal binding site [ion binding]; metal-binding site 931276011310 active site 931276011311 I-site; other site 931276011312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276011313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276011314 putative substrate translocation pore; other site 931276011315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276011316 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931276011317 MarR family; Region: MarR_2; pfam12802 931276011318 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276011319 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 931276011320 NodB motif; other site 931276011321 active site 931276011322 catalytic site [active] 931276011323 Zn binding site [ion binding]; other site 931276011324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276011325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276011326 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931276011327 Walker A/P-loop; other site 931276011328 ATP binding site [chemical binding]; other site 931276011329 Q-loop/lid; other site 931276011330 ABC transporter signature motif; other site 931276011331 Walker B; other site 931276011332 D-loop; other site 931276011333 H-loop/switch region; other site 931276011334 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276011335 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276011336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276011337 Walker A/P-loop; other site 931276011338 ATP binding site [chemical binding]; other site 931276011339 Q-loop/lid; other site 931276011340 ABC transporter signature motif; other site 931276011341 Walker B; other site 931276011342 D-loop; other site 931276011343 H-loop/switch region; other site 931276011344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276011345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276011346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276011347 dimerization interface [polypeptide binding]; other site 931276011348 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276011349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276011350 dimerization interface [polypeptide binding]; other site 931276011351 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276011352 dimer interface [polypeptide binding]; other site 931276011353 putative CheW interface [polypeptide binding]; other site 931276011354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276011355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276011356 binding surface 931276011357 TPR motif; other site 931276011358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276011359 binding surface 931276011360 TPR motif; other site 931276011361 Tetratricopeptide repeat; Region: TPR_16; pfam13432 931276011362 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 931276011363 MarR family; Region: MarR_2; cl17246 931276011364 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276011365 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276011366 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276011367 Metal-binding active site; metal-binding site 931276011368 AP (apurinic/apyrimidinic) site pocket; other site 931276011369 hypothetical protein; Validated; Region: PRK02101 931276011370 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 931276011371 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931276011372 catalytic triad [active] 931276011373 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276011374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276011375 active site 931276011376 phosphorylation site [posttranslational modification] 931276011377 intermolecular recognition site; other site 931276011378 dimerization interface [polypeptide binding]; other site 931276011379 Rubrerythrin [Energy production and conversion]; Region: COG1592 931276011380 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931276011381 iron binding site [ion binding]; other site 931276011382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276011383 binding surface 931276011384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276011385 TPR motif; other site 931276011386 ankyrin repeat protein; Provisional; Region: PHA02859 931276011387 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 931276011388 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 931276011389 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 931276011390 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931276011391 active site 931276011392 catalytic tetrad [active] 931276011393 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276011394 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 931276011395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276011396 substrate binding pocket [chemical binding]; other site 931276011397 membrane-bound complex binding site; other site 931276011398 hinge residues; other site 931276011399 peroxiredoxin; Region: AhpC; TIGR03137 931276011400 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 931276011401 dimer interface [polypeptide binding]; other site 931276011402 decamer (pentamer of dimers) interface [polypeptide binding]; other site 931276011403 catalytic triad [active] 931276011404 peroxidatic and resolving cysteines [active] 931276011405 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 931276011406 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 931276011407 catalytic residue [active] 931276011408 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 931276011409 catalytic residues [active] 931276011410 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276011411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276011412 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276011413 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276011414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276011415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276011416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276011417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276011418 metal binding site [ion binding]; metal-binding site 931276011419 active site 931276011420 I-site; other site 931276011421 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 931276011422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276011423 S-adenosylmethionine binding site [chemical binding]; other site 931276011424 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 931276011425 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276011426 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276011427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276011428 Coenzyme A binding pocket [chemical binding]; other site 931276011429 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 931276011430 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 931276011431 Protein of unknown function DUF2625; Region: DUF2625; cl08177 931276011432 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 931276011433 putative active site [active] 931276011434 putative metal binding site [ion binding]; other site 931276011435 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 931276011436 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 931276011437 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 931276011438 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 931276011439 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 931276011440 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 931276011441 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 931276011442 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 931276011443 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 931276011444 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 931276011445 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 931276011446 substrate binding site [chemical binding]; other site 931276011447 dimer interface [polypeptide binding]; other site 931276011448 ATP binding site [chemical binding]; other site 931276011449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276011450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276011451 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 931276011452 putative dimerization interface [polypeptide binding]; other site 931276011453 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 931276011454 FMN binding site [chemical binding]; other site 931276011455 dimer interface [polypeptide binding]; other site 931276011456 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276011457 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 931276011458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276011459 RNA binding surface [nucleotide binding]; other site 931276011460 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 931276011461 active site 931276011462 uracil binding [chemical binding]; other site 931276011463 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 931276011464 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 931276011465 putative ligand binding site [chemical binding]; other site 931276011466 putative NAD binding site [chemical binding]; other site 931276011467 catalytic site [active] 931276011468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276011469 binding surface 931276011470 Tetratricopeptide repeat; Region: TPR_16; pfam13432 931276011471 TPR motif; other site 931276011472 TPR repeat; Region: TPR_11; pfam13414 931276011473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276011474 binding surface 931276011475 TPR motif; other site 931276011476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276011477 binding surface 931276011478 TPR motif; other site 931276011479 TPR repeat; Region: TPR_11; pfam13414 931276011480 Domain of unknown function (DUF386); Region: DUF386; cl01047 931276011481 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931276011482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276011483 NAD(P) binding site [chemical binding]; other site 931276011484 active site 931276011485 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 931276011486 BNR repeat-like domain; Region: BNR_2; pfam13088 931276011487 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 931276011488 Na binding site [ion binding]; other site 931276011489 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 931276011490 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 931276011491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 931276011492 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931276011493 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 931276011494 putative active site [active] 931276011495 metal binding site [ion binding]; metal-binding site 931276011496 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 931276011497 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 931276011498 inhibitor site; inhibition site 931276011499 active site 931276011500 dimer interface [polypeptide binding]; other site 931276011501 catalytic residue [active] 931276011502 Propionate catabolism activator; Region: PrpR_N; pfam06506 931276011503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 931276011504 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 931276011505 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276011506 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276011507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276011508 Walker A/P-loop; other site 931276011509 ATP binding site [chemical binding]; other site 931276011510 Q-loop/lid; other site 931276011511 ABC transporter signature motif; other site 931276011512 Walker B; other site 931276011513 D-loop; other site 931276011514 H-loop/switch region; other site 931276011515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276011516 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276011517 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 931276011518 PilZ domain; Region: PilZ; pfam07238 931276011519 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276011520 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276011521 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276011522 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 931276011523 Protein export membrane protein; Region: SecD_SecF; cl14618 931276011524 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931276011525 intersubunit interface [polypeptide binding]; other site 931276011526 active site 931276011527 zinc binding site [ion binding]; other site 931276011528 Na+ binding site [ion binding]; other site 931276011529 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931276011530 intersubunit interface [polypeptide binding]; other site 931276011531 active site 931276011532 zinc binding site [ion binding]; other site 931276011533 Na+ binding site [ion binding]; other site 931276011534 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 931276011535 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 931276011536 active site 931276011537 P-loop; other site 931276011538 phosphorylation site [posttranslational modification] 931276011539 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 931276011540 PRD domain; Region: PRD; pfam00874 931276011541 PRD domain; Region: PRD; pfam00874 931276011542 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 931276011543 active site 931276011544 P-loop; other site 931276011545 phosphorylation site [posttranslational modification] 931276011546 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931276011547 active site 931276011548 phosphorylation site [posttranslational modification] 931276011549 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 931276011550 Cache domain; Region: Cache_1; pfam02743 931276011551 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276011552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276011553 dimerization interface [polypeptide binding]; other site 931276011554 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276011555 dimer interface [polypeptide binding]; other site 931276011556 putative CheW interface [polypeptide binding]; other site 931276011557 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 931276011558 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931276011559 putative active site [active] 931276011560 putative FMN binding site [chemical binding]; other site 931276011561 putative substrate binding site [chemical binding]; other site 931276011562 putative catalytic residue [active] 931276011563 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 931276011564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276011565 non-specific DNA binding site [nucleotide binding]; other site 931276011566 salt bridge; other site 931276011567 sequence-specific DNA binding site [nucleotide binding]; other site 931276011568 Cupin domain; Region: Cupin_2; pfam07883 931276011569 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 931276011570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 931276011571 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 931276011572 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 931276011573 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 931276011574 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 931276011575 putative active site [active] 931276011576 hypothetical protein; Provisional; Region: PRK05463 931276011577 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 931276011578 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 931276011579 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 931276011580 homodimer interface [polypeptide binding]; other site 931276011581 substrate-cofactor binding pocket; other site 931276011582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276011583 catalytic residue [active] 931276011584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 931276011585 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 931276011586 AsnC family; Region: AsnC_trans_reg; pfam01037 931276011587 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 931276011588 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 931276011589 Walker A/P-loop; other site 931276011590 ATP binding site [chemical binding]; other site 931276011591 Q-loop/lid; other site 931276011592 ABC transporter signature motif; other site 931276011593 Walker B; other site 931276011594 D-loop; other site 931276011595 H-loop/switch region; other site 931276011596 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 931276011597 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 931276011598 Walker A/P-loop; other site 931276011599 ATP binding site [chemical binding]; other site 931276011600 Q-loop/lid; other site 931276011601 ABC transporter signature motif; other site 931276011602 Walker B; other site 931276011603 D-loop; other site 931276011604 H-loop/switch region; other site 931276011605 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 931276011606 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 931276011607 TM-ABC transporter signature motif; other site 931276011608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276011609 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 931276011610 TM-ABC transporter signature motif; other site 931276011611 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931276011612 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 931276011613 putative ligand binding site [chemical binding]; other site 931276011614 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 931276011615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276011616 NAD(P) binding site [chemical binding]; other site 931276011617 active site 931276011618 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 931276011619 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276011620 DNA binding residues [nucleotide binding] 931276011621 dimer interface [polypeptide binding]; other site 931276011622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276011623 S-adenosylmethionine binding site [chemical binding]; other site 931276011624 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 931276011625 Part of AAA domain; Region: AAA_19; pfam13245 931276011626 Family description; Region: UvrD_C_2; pfam13538 931276011627 Pirin; Region: Pirin; pfam02678 931276011628 Pirin-related protein [General function prediction only]; Region: COG1741 931276011629 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 931276011630 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276011631 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276011632 ligand binding site [chemical binding]; other site 931276011633 calcium binding site [ion binding]; other site 931276011634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276011635 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 931276011636 active site 931276011637 DNA binding site [nucleotide binding] 931276011638 Int/Topo IB signature motif; other site 931276011639 Uncharacterized conserved protein [Function unknown]; Region: COG4715 931276011640 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 931276011641 Flagellin N-methylase; Region: FliB; pfam03692 931276011642 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 931276011643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276011644 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 931276011645 Walker A motif; other site 931276011646 ATP binding site [chemical binding]; other site 931276011647 Walker B motif; other site 931276011648 Uncharacterized conserved protein [Function unknown]; Region: COG3410 931276011649 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 931276011650 homodimer interface [polypeptide binding]; other site 931276011651 chemical substrate binding site [chemical binding]; other site 931276011652 oligomer interface [polypeptide binding]; other site 931276011653 metal binding site [ion binding]; metal-binding site 931276011654 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 931276011655 Aspartyl protease; Region: Asp_protease_2; pfam13650 931276011656 inhibitor binding site; inhibition site 931276011657 catalytic motif [active] 931276011658 Catalytic residue [active] 931276011659 Active site flap [active] 931276011660 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 931276011661 GIY-YIG motif/motif A; other site 931276011662 active site 931276011663 catalytic site [active] 931276011664 putative DNA binding site [nucleotide binding]; other site 931276011665 metal binding site [ion binding]; metal-binding site 931276011666 UvrB/uvrC motif; Region: UVR; pfam02151 931276011667 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276011668 Protein of unknown function (DUF524); Region: DUF524; pfam04411 931276011669 DpnII restriction endonuclease; Region: DpnII; pfam04556 931276011670 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 931276011671 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 931276011672 DNA methylase; Region: N6_N4_Mtase; pfam01555 931276011673 DNA methylase; Region: N6_N4_Mtase; pfam01555 931276011674 DNA methylase; Region: N6_N4_Mtase; cl17433 931276011675 SIR2-like domain; Region: SIR2_2; pfam13289 931276011676 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 931276011677 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931276011678 Magnesium ion binding site [ion binding]; other site 931276011679 Uncharacterized conserved protein [Function unknown]; Region: COG3586 931276011680 HNH endonuclease; Region: HNH_4; pfam13395 931276011681 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 931276011682 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 931276011683 conserved cys residue [active] 931276011684 Predicted transcriptional regulator [Transcription]; Region: COG2378 931276011685 HTH domain; Region: HTH_11; pfam08279 931276011686 WYL domain; Region: WYL; pfam13280 931276011687 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 931276011688 metal binding site [ion binding]; metal-binding site 931276011689 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931276011690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276011691 S-adenosylmethionine binding site [chemical binding]; other site 931276011692 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 931276011693 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 931276011694 Acylphosphatase; Region: Acylphosphatase; pfam00708 931276011695 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 931276011696 HypF finger; Region: zf-HYPF; pfam07503 931276011697 HypF finger; Region: zf-HYPF; pfam07503 931276011698 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 931276011699 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 931276011700 dimerization interface [polypeptide binding]; other site 931276011701 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 931276011702 ATP binding site [chemical binding]; other site 931276011703 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 931276011704 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 931276011705 HupF/HypC family; Region: HupF_HypC; pfam01455 931276011706 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 931276011707 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 931276011708 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 931276011709 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276011710 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 931276011711 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 931276011712 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 931276011713 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 931276011714 putative substrate-binding site; other site 931276011715 nickel binding site [ion binding]; other site 931276011716 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 931276011717 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 931276011718 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 931276011719 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931276011720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276011721 S-adenosylmethionine binding site [chemical binding]; other site 931276011722 RQC domain; Region: RQC; pfam09382 931276011723 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 931276011724 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 931276011725 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 931276011726 Rhomboid family; Region: Rhomboid; pfam01694 931276011727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931276011728 TPR motif; other site 931276011729 methionine sulfoxide reductase B; Provisional; Region: PRK00222 931276011730 SelR domain; Region: SelR; pfam01641 931276011731 PAS domain S-box; Region: sensory_box; TIGR00229 931276011732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276011733 putative active site [active] 931276011734 heme pocket [chemical binding]; other site 931276011735 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276011736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276011737 metal binding site [ion binding]; metal-binding site 931276011738 active site 931276011739 I-site; other site 931276011740 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276011741 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276011742 Zn2+ binding site [ion binding]; other site 931276011743 Mg2+ binding site [ion binding]; other site 931276011744 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 931276011745 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 931276011746 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 931276011747 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 931276011748 putative active site [active] 931276011749 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 931276011750 putative deacylase active site [active] 931276011751 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276011752 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276011753 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276011754 nucleotide binding site [chemical binding]; other site 931276011755 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 931276011756 active site 931276011757 catalytic site [active] 931276011758 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 931276011759 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 931276011760 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276011761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276011762 dimer interface [polypeptide binding]; other site 931276011763 conserved gate region; other site 931276011764 putative PBP binding loops; other site 931276011765 ABC-ATPase subunit interface; other site 931276011766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276011767 dimer interface [polypeptide binding]; other site 931276011768 conserved gate region; other site 931276011769 putative PBP binding loops; other site 931276011770 ABC-ATPase subunit interface; other site 931276011771 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276011772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 931276011773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276011774 Uncharacterized conserved protein [Function unknown]; Region: COG3538 931276011775 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 931276011776 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931276011777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276011778 DNA-binding site [nucleotide binding]; DNA binding site 931276011779 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276011780 dimerization interface [polypeptide binding]; other site 931276011781 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276011782 ligand binding site [chemical binding]; other site 931276011783 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 931276011784 alpha-galactosidase; Region: PLN02808; cl17638 931276011785 putative alpha-glucosidase; Provisional; Region: PRK10658 931276011786 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 931276011787 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 931276011788 putative active site [active] 931276011789 putative catalytic site [active] 931276011790 Cupin domain; Region: Cupin_2; pfam07883 931276011791 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276011792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276011793 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 931276011794 Palmitoyl protein thioesterase; Region: Palm_thioest; cl15849 931276011795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 931276011796 Proteins of 100 residues with WXG; Region: WXG100; cl02005 931276011797 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 931276011798 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 931276011799 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 931276011800 hypothetical protein; Reviewed; Region: PRK09588 931276011801 TROVE domain; Region: TROVE; pfam05731 931276011802 WYL domain; Region: WYL; pfam13280 931276011803 WYL domain; Region: WYL; pfam13280 931276011804 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276011805 RDD family; Region: RDD; pfam06271 931276011806 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 931276011807 tandem repeat interface [polypeptide binding]; other site 931276011808 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 931276011809 oligomer interface [polypeptide binding]; other site 931276011810 active site residues [active] 931276011811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276011812 dimer interface [polypeptide binding]; other site 931276011813 conserved gate region; other site 931276011814 putative PBP binding loops; other site 931276011815 ABC-ATPase subunit interface; other site 931276011816 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 931276011817 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 931276011818 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 931276011819 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 931276011820 Walker A/P-loop; other site 931276011821 ATP binding site [chemical binding]; other site 931276011822 Q-loop/lid; other site 931276011823 ABC transporter signature motif; other site 931276011824 Walker B; other site 931276011825 D-loop; other site 931276011826 H-loop/switch region; other site 931276011827 FOG: CBS domain [General function prediction only]; Region: COG0517 931276011828 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 931276011829 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931276011830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276011831 DNA-binding site [nucleotide binding]; DNA binding site 931276011832 TrkA-C domain; Region: TrkA_C; pfam02080 931276011833 allantoate amidohydrolase; Reviewed; Region: PRK09290 931276011834 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 931276011835 active site 931276011836 metal binding site [ion binding]; metal-binding site 931276011837 dimer interface [polypeptide binding]; other site 931276011838 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 931276011839 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 931276011840 homodimer interface [polypeptide binding]; other site 931276011841 active site 931276011842 FMN binding site [chemical binding]; other site 931276011843 substrate binding site [chemical binding]; other site 931276011844 phenylhydantoinase; Validated; Region: PRK08323 931276011845 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 931276011846 tetramer interface [polypeptide binding]; other site 931276011847 active site 931276011848 NMT1/THI5 like; Region: NMT1; pfam09084 931276011849 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 931276011850 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931276011851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276011852 dimer interface [polypeptide binding]; other site 931276011853 conserved gate region; other site 931276011854 putative PBP binding loops; other site 931276011855 ABC-ATPase subunit interface; other site 931276011856 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931276011857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276011858 dimer interface [polypeptide binding]; other site 931276011859 conserved gate region; other site 931276011860 putative PBP binding loops; other site 931276011861 ABC-ATPase subunit interface; other site 931276011862 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 931276011863 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931276011864 Walker A/P-loop; other site 931276011865 ATP binding site [chemical binding]; other site 931276011866 Q-loop/lid; other site 931276011867 ABC transporter signature motif; other site 931276011868 Walker B; other site 931276011869 D-loop; other site 931276011870 H-loop/switch region; other site 931276011871 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931276011872 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276011873 active site 931276011874 NAD binding site [chemical binding]; other site 931276011875 metal binding site [ion binding]; metal-binding site 931276011876 hypothetical protein; Provisional; Region: PRK06062 931276011877 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931276011878 inhibitor-cofactor binding pocket; inhibition site 931276011879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276011880 catalytic residue [active] 931276011881 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 931276011882 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276011883 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 931276011884 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 931276011885 FAD binding site [chemical binding]; other site 931276011886 homotetramer interface [polypeptide binding]; other site 931276011887 substrate binding pocket [chemical binding]; other site 931276011888 catalytic base [active] 931276011889 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 931276011890 FAD binding domain; Region: FAD_binding_4; pfam01565 931276011891 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 931276011892 L-lactate permease; Region: Lactate_perm; cl00701 931276011893 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931276011894 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 931276011895 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931276011896 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 931276011897 Ligand binding site [chemical binding]; other site 931276011898 Electron transfer flavoprotein domain; Region: ETF; pfam01012 931276011899 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276011900 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931276011901 DNA binding residues [nucleotide binding] 931276011902 drug binding residues [chemical binding]; other site 931276011903 dimer interface [polypeptide binding]; other site 931276011904 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276011905 PAS fold; Region: PAS_3; pfam08447 931276011906 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 931276011907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276011908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276011909 metal binding site [ion binding]; metal-binding site 931276011910 active site 931276011911 I-site; other site 931276011912 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 931276011913 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 931276011914 dimer interface [polypeptide binding]; other site 931276011915 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 931276011916 dimer interface [polypeptide binding]; other site 931276011917 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 931276011918 putative hydrophobic ligand binding site [chemical binding]; other site 931276011919 3D domain; Region: 3D; cl01439 931276011920 EDD domain protein, DegV family; Region: DegV; TIGR00762 931276011921 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931276011922 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 931276011923 PAS domain; Region: PAS_8; pfam13188 931276011924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276011925 dimer interface [polypeptide binding]; other site 931276011926 phosphorylation site [posttranslational modification] 931276011927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276011928 ATP binding site [chemical binding]; other site 931276011929 G-X-G motif; other site 931276011930 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 931276011931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276011932 Walker A motif; other site 931276011933 ATP binding site [chemical binding]; other site 931276011934 Walker B motif; other site 931276011935 arginine finger; other site 931276011936 Peptidase family M41; Region: Peptidase_M41; pfam01434 931276011937 Protein of unknown function (DUF342); Region: DUF342; pfam03961 931276011938 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276011939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276011940 metal binding site [ion binding]; metal-binding site 931276011941 active site 931276011942 I-site; other site 931276011943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931276011944 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276011945 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 931276011946 putative dimer interface [polypeptide binding]; other site 931276011947 catalytic triad [active] 931276011948 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 931276011949 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 931276011950 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 931276011951 trimer interface [polypeptide binding]; other site 931276011952 active site 931276011953 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 931276011954 catalytic site [active] 931276011955 Carboxylesterase family; Region: COesterase; pfam00135 931276011956 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 931276011957 substrate binding pocket [chemical binding]; other site 931276011958 catalytic triad [active] 931276011959 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276011960 polyphosphate kinase; Provisional; Region: PRK05443 931276011961 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 931276011962 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 931276011963 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 931276011964 putative domain interface [polypeptide binding]; other site 931276011965 putative active site [active] 931276011966 catalytic site [active] 931276011967 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 931276011968 putative domain interface [polypeptide binding]; other site 931276011969 putative active site [active] 931276011970 catalytic site [active] 931276011971 exopolyphosphatase; Region: exo_poly_only; TIGR03706 931276011972 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 931276011973 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931276011974 Domain of unknown function DUF20; Region: UPF0118; pfam01594 931276011975 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 931276011976 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276011977 MATE family multidrug exporter; Provisional; Region: PRK10189 931276011978 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 931276011979 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276011980 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276011981 dimer interface [polypeptide binding]; other site 931276011982 putative CheW interface [polypeptide binding]; other site 931276011983 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 931276011984 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276011985 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 931276011986 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276011987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 931276011988 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 931276011989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 931276011990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 931276011991 binding surface 931276011992 TPR motif; other site 931276011993 TPR repeat; Region: TPR_11; pfam13414 931276011994 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 931276011995 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 931276011996 RecX family; Region: RecX; cl00936 931276011997 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 931276011998 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 931276011999 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 931276012000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276012001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276012002 active site 931276012003 phosphorylation site [posttranslational modification] 931276012004 intermolecular recognition site; other site 931276012005 dimerization interface [polypeptide binding]; other site 931276012006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276012007 DNA binding site [nucleotide binding] 931276012008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276012009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276012010 dimerization interface [polypeptide binding]; other site 931276012011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276012012 dimer interface [polypeptide binding]; other site 931276012013 phosphorylation site [posttranslational modification] 931276012014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276012015 ATP binding site [chemical binding]; other site 931276012016 Mg2+ binding site [ion binding]; other site 931276012017 G-X-G motif; other site 931276012018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276012019 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 931276012020 NAD(P) binding site [chemical binding]; other site 931276012021 active site 931276012022 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 931276012023 putative active site [active] 931276012024 putative metal binding site [ion binding]; other site 931276012025 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 931276012026 active site 931276012027 homodimer interface [polypeptide binding]; other site 931276012028 homotetramer interface [polypeptide binding]; other site 931276012029 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276012030 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276012031 Walker A/P-loop; other site 931276012032 ATP binding site [chemical binding]; other site 931276012033 Q-loop/lid; other site 931276012034 ABC transporter signature motif; other site 931276012035 Walker B; other site 931276012036 D-loop; other site 931276012037 H-loop/switch region; other site 931276012038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276012039 dimer interface [polypeptide binding]; other site 931276012040 conserved gate region; other site 931276012041 putative PBP binding loops; other site 931276012042 ABC-ATPase subunit interface; other site 931276012043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276012044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276012045 substrate binding pocket [chemical binding]; other site 931276012046 membrane-bound complex binding site; other site 931276012047 hinge residues; other site 931276012048 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276012049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276012050 substrate binding pocket [chemical binding]; other site 931276012051 membrane-bound complex binding site; other site 931276012052 hinge residues; other site 931276012053 Transcriptional regulators [Transcription]; Region: GntR; COG1802 931276012054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276012055 DNA-binding site [nucleotide binding]; DNA binding site 931276012056 FCD domain; Region: FCD; pfam07729 931276012057 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 931276012058 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 931276012059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276012060 motif II; other site 931276012061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276012062 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 931276012063 active site triad [active] 931276012064 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 931276012065 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 931276012066 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276012067 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276012068 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276012069 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931276012070 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 931276012071 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 931276012072 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 931276012073 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276012074 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276012075 Coenzyme A binding pocket [chemical binding]; other site 931276012076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931276012077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276012078 Coenzyme A binding pocket [chemical binding]; other site 931276012079 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 931276012080 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 931276012081 conserved cys residue [active] 931276012082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931276012083 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931276012084 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 931276012085 putative active site [active] 931276012086 putative CoA binding site [chemical binding]; other site 931276012087 nudix motif; other site 931276012088 metal binding site [ion binding]; metal-binding site 931276012089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276012090 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276012091 active site 931276012092 motif I; other site 931276012093 motif II; other site 931276012094 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276012095 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 931276012096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276012097 motif II; other site 931276012098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276012099 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 931276012100 active site 931276012101 Predicted transcriptional regulator [Transcription]; Region: COG4189 931276012102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276012103 dimerization interface [polypeptide binding]; other site 931276012104 putative DNA binding site [nucleotide binding]; other site 931276012105 putative Zn2+ binding site [ion binding]; other site 931276012106 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 931276012107 substrate binding site [chemical binding]; other site 931276012108 active site 931276012109 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 931276012110 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 931276012111 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276012112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276012113 dimer interface [polypeptide binding]; other site 931276012114 conserved gate region; other site 931276012115 putative PBP binding loops; other site 931276012116 ABC-ATPase subunit interface; other site 931276012117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276012118 dimer interface [polypeptide binding]; other site 931276012119 conserved gate region; other site 931276012120 putative PBP binding loops; other site 931276012121 ABC-ATPase subunit interface; other site 931276012122 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276012123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276012124 Protein of unknown function, DUF624; Region: DUF624; pfam04854 931276012125 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 931276012126 active site 931276012127 putative catalytic site [active] 931276012128 DNA binding site [nucleotide binding] 931276012129 putative phosphate binding site [ion binding]; other site 931276012130 metal binding site A [ion binding]; metal-binding site 931276012131 AP binding site [nucleotide binding]; other site 931276012132 metal binding site B [ion binding]; metal-binding site 931276012133 Membrane transport protein; Region: Mem_trans; cl09117 931276012134 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 931276012135 hypothetical protein; Provisional; Region: PRK00955 931276012136 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 931276012137 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 931276012138 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 931276012139 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276012140 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 931276012141 putative active site [active] 931276012142 putative metal binding site [ion binding]; other site 931276012143 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 931276012144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276012145 putative DNA binding site [nucleotide binding]; other site 931276012146 putative Zn2+ binding site [ion binding]; other site 931276012147 AsnC family; Region: AsnC_trans_reg; pfam01037 931276012148 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 931276012149 Aspartase; Region: Aspartase; cd01357 931276012150 active sites [active] 931276012151 tetramer interface [polypeptide binding]; other site 931276012152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276012153 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 931276012154 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276012155 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276012156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276012157 dimer interface [polypeptide binding]; other site 931276012158 putative CheW interface [polypeptide binding]; other site 931276012159 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276012160 hypothetical protein; Provisional; Region: PRK11622 931276012161 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 931276012162 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 931276012163 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 931276012164 active site 931276012165 catalytic site [active] 931276012166 metal binding site [ion binding]; metal-binding site 931276012167 dimer interface [polypeptide binding]; other site 931276012168 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276012169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 931276012170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276012171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276012172 dimer interface [polypeptide binding]; other site 931276012173 conserved gate region; other site 931276012174 putative PBP binding loops; other site 931276012175 ABC-ATPase subunit interface; other site 931276012176 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 931276012177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276012178 ABC-ATPase subunit interface; other site 931276012179 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 931276012180 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 931276012181 Walker A/P-loop; other site 931276012182 ATP binding site [chemical binding]; other site 931276012183 Q-loop/lid; other site 931276012184 ABC transporter signature motif; other site 931276012185 Walker B; other site 931276012186 D-loop; other site 931276012187 H-loop/switch region; other site 931276012188 Putative motility protein; Region: YjfB_motility; pfam14070 931276012189 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931276012190 catalytic residues [active] 931276012191 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 931276012192 active site residue [active] 931276012193 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931276012194 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276012195 ligand binding site [chemical binding]; other site 931276012196 flexible hinge region; other site 931276012197 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 931276012198 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 931276012199 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 931276012200 active site 931276012201 substrate binding site [chemical binding]; other site 931276012202 ATP binding site [chemical binding]; other site 931276012203 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931276012204 HPr interaction site; other site 931276012205 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276012206 active site 931276012207 phosphorylation site [posttranslational modification] 931276012208 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 931276012209 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 931276012210 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 931276012211 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276012212 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 931276012213 HNH endonuclease; Region: HNH_3; pfam13392 931276012214 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 931276012215 putative ADP-ribose binding site [chemical binding]; other site 931276012216 putative active site [active] 931276012217 manganese transport transcriptional regulator; Provisional; Region: PRK03902 931276012218 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 931276012219 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 931276012220 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 931276012221 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 931276012222 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 931276012223 G1 box; other site 931276012224 GTP/Mg2+ binding site [chemical binding]; other site 931276012225 Switch I region; other site 931276012226 G2 box; other site 931276012227 G3 box; other site 931276012228 Switch II region; other site 931276012229 G4 box; other site 931276012230 G5 box; other site 931276012231 Nucleoside recognition; Region: Gate; pfam07670 931276012232 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 931276012233 Nucleoside recognition; Region: Gate; pfam07670 931276012234 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931276012235 catalytic core [active] 931276012236 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 931276012237 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 931276012238 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 931276012239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276012240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276012241 cobalt transport protein CbiN; Provisional; Region: PRK02898 931276012242 cobalt transport protein CbiM; Validated; Region: PRK08319 931276012243 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 931276012244 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931276012245 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931276012246 Walker A/P-loop; other site 931276012247 ATP binding site [chemical binding]; other site 931276012248 Q-loop/lid; other site 931276012249 ABC transporter signature motif; other site 931276012250 Walker B; other site 931276012251 D-loop; other site 931276012252 H-loop/switch region; other site 931276012253 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 931276012254 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931276012255 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276012256 DNA binding residues [nucleotide binding] 931276012257 drug binding residues [chemical binding]; other site 931276012258 dimer interface [polypeptide binding]; other site 931276012259 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276012260 SnoaL-like domain; Region: SnoaL_2; pfam12680 931276012261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 931276012262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276012263 NAD(P) binding site [chemical binding]; other site 931276012264 active site 931276012265 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931276012266 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276012267 DNA binding residues [nucleotide binding] 931276012268 putative dimer interface [polypeptide binding]; other site 931276012269 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931276012270 Rubredoxin; Region: Rubredoxin; pfam00301 931276012271 iron binding site [ion binding]; other site 931276012272 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 931276012273 Rubrerythrin [Energy production and conversion]; Region: COG1592 931276012274 diiron binding motif [ion binding]; other site 931276012275 putative pectinesterase; Region: PLN02432; cl01911 931276012276 Pectinesterase; Region: Pectinesterase; pfam01095 931276012277 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 931276012278 dimer interface [polypeptide binding]; other site 931276012279 FMN binding site [chemical binding]; other site 931276012280 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 931276012281 dimer interface [polypeptide binding]; other site 931276012282 FMN binding site [chemical binding]; other site 931276012283 Pirin; Region: Pirin; pfam02678 931276012284 Pirin-related protein [General function prediction only]; Region: COG1741 931276012285 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276012286 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276012287 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 931276012288 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 931276012289 MFS/sugar transport protein; Region: MFS_2; pfam13347 931276012290 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 931276012291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276012292 putative substrate translocation pore; other site 931276012293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276012294 dimer interface [polypeptide binding]; other site 931276012295 putative CheW interface [polypeptide binding]; other site 931276012296 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276012297 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276012298 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276012299 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276012300 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276012301 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276012302 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276012303 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276012304 Metal-binding active site; metal-binding site 931276012305 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 931276012306 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276012307 ligand binding site [chemical binding]; other site 931276012308 calcium binding site [ion binding]; other site 931276012309 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276012310 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 931276012311 active site 931276012312 catalytic residues [active] 931276012313 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 931276012314 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 931276012315 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 931276012316 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 931276012317 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 931276012318 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 931276012319 active site 931276012320 active site 931276012321 catalytic residues [active] 931276012322 Response regulator receiver domain; Region: Response_reg; pfam00072 931276012323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276012324 active site 931276012325 phosphorylation site [posttranslational modification] 931276012326 intermolecular recognition site; other site 931276012327 dimerization interface [polypeptide binding]; other site 931276012328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276012329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276012330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276012331 dimerization interface [polypeptide binding]; other site 931276012332 Histidine kinase; Region: His_kinase; pfam06580 931276012333 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 931276012334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276012335 ATP binding site [chemical binding]; other site 931276012336 Mg2+ binding site [ion binding]; other site 931276012337 G-X-G motif; other site 931276012338 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276012339 Cache domain; Region: Cache_1; pfam02743 931276012340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276012341 dimerization interface [polypeptide binding]; other site 931276012342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276012343 dimer interface [polypeptide binding]; other site 931276012344 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276012345 putative CheW interface [polypeptide binding]; other site 931276012346 DJ-1 family protein; Region: not_thiJ; TIGR01383 931276012347 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 931276012348 conserved cys residue [active] 931276012349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276012350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276012351 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 931276012352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 931276012353 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276012354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276012355 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 931276012356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276012357 nucleotide binding site [chemical binding]; other site 931276012358 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276012359 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276012360 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276012361 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276012362 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276012363 dimer interface [polypeptide binding]; other site 931276012364 putative CheW interface [polypeptide binding]; other site 931276012365 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276012366 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 931276012367 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 931276012368 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 931276012369 inhibitor binding site; inhibition site 931276012370 active site 931276012371 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 931276012372 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 931276012373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 931276012374 phosphorylation site [posttranslational modification] 931276012375 intermolecular recognition site; other site 931276012376 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 931276012377 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276012378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276012379 putative substrate translocation pore; other site 931276012380 Response regulator receiver domain; Region: Response_reg; pfam00072 931276012381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276012382 active site 931276012383 phosphorylation site [posttranslational modification] 931276012384 intermolecular recognition site; other site 931276012385 dimerization interface [polypeptide binding]; other site 931276012386 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276012387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276012388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276012389 dimerization interface [polypeptide binding]; other site 931276012390 Histidine kinase; Region: His_kinase; pfam06580 931276012391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276012392 ATP binding site [chemical binding]; other site 931276012393 Mg2+ binding site [ion binding]; other site 931276012394 G-X-G motif; other site 931276012395 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276012396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276012397 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 931276012398 Cupin domain; Region: Cupin_2; pfam07883 931276012399 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276012400 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276012401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276012402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276012403 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276012404 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276012405 Trehalose utilisation; Region: ThuA; pfam06283 931276012406 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 931276012407 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 931276012408 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 931276012409 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276012410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276012411 putative substrate translocation pore; other site 931276012412 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276012413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276012414 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276012415 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276012416 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276012417 DNA interaction; other site 931276012418 Metal-binding active site; metal-binding site 931276012419 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 931276012420 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 931276012421 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276012422 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276012423 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276012424 Cupin domain; Region: Cupin_2; pfam07883 931276012425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276012426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276012427 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276012428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276012429 Coenzyme A binding pocket [chemical binding]; other site 931276012430 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 931276012431 Predicted membrane protein [Function unknown]; Region: COG2323 931276012432 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 931276012433 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 931276012434 stage V sporulation protein AD; Provisional; Region: PRK12404 931276012435 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 931276012436 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 931276012437 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 931276012438 MarR family; Region: MarR_2; pfam12802 931276012439 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 931276012440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276012441 putative substrate translocation pore; other site 931276012442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276012443 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 931276012444 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 931276012445 lipoyl-biotinyl attachment site [posttranslational modification]; other site 931276012446 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276012447 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276012448 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 931276012449 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276012450 MarR family; Region: MarR_2; pfam12802 931276012451 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 931276012452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276012453 S-adenosylmethionine binding site [chemical binding]; other site 931276012454 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 931276012455 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 931276012456 active site 931276012457 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 931276012458 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 931276012459 active site 931276012460 intersubunit interactions; other site 931276012461 catalytic residue [active] 931276012462 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 931276012463 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276012464 PYR/PP interface [polypeptide binding]; other site 931276012465 dimer interface [polypeptide binding]; other site 931276012466 TPP binding site [chemical binding]; other site 931276012467 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276012468 transketolase; Reviewed; Region: PRK05899 931276012469 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931276012470 TPP-binding site [chemical binding]; other site 931276012471 dimer interface [polypeptide binding]; other site 931276012472 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 931276012473 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276012474 AP (apurinic/apyrimidinic) site pocket; other site 931276012475 DNA interaction; other site 931276012476 Metal-binding active site; metal-binding site 931276012477 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 931276012478 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 931276012479 intersubunit interface [polypeptide binding]; other site 931276012480 active site 931276012481 Zn2+ binding site [ion binding]; other site 931276012482 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 931276012483 active site 931276012484 P-loop; other site 931276012485 phosphorylation site [posttranslational modification] 931276012486 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 931276012487 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931276012488 active site 931276012489 phosphorylation site [posttranslational modification] 931276012490 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 931276012491 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931276012492 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931276012493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276012494 putative DNA binding site [nucleotide binding]; other site 931276012495 putative Zn2+ binding site [ion binding]; other site 931276012496 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931276012497 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 931276012498 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276012499 active site 931276012500 NAD binding site [chemical binding]; other site 931276012501 metal binding site [ion binding]; metal-binding site 931276012502 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276012503 active site 931276012504 P-loop; other site 931276012505 phosphorylation site [posttranslational modification] 931276012506 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276012507 beta-galactosidase; Region: BGL; TIGR03356 931276012508 methionine cluster; other site 931276012509 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 931276012510 active site 931276012511 phosphorylation site [posttranslational modification] 931276012512 metal binding site [ion binding]; metal-binding site 931276012513 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276012514 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 931276012515 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276012516 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276012517 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276012518 putative active site [active] 931276012519 Dehydratase family; Region: ILVD_EDD; pfam00920 931276012520 Transcriptional regulators [Transcription]; Region: FadR; COG2186 931276012521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276012522 DNA-binding site [nucleotide binding]; DNA binding site 931276012523 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 931276012524 H+ Antiporter protein; Region: 2A0121; TIGR00900 931276012525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276012526 putative substrate translocation pore; other site 931276012527 Amino acid permease; Region: AA_permease_2; pfam13520 931276012528 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 931276012529 major vault protein; Provisional; Region: PTZ00491 931276012530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276012531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276012532 dimerization interface [polypeptide binding]; other site 931276012533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276012534 dimer interface [polypeptide binding]; other site 931276012535 phosphorylation site [posttranslational modification] 931276012536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276012537 ATP binding site [chemical binding]; other site 931276012538 Mg2+ binding site [ion binding]; other site 931276012539 G-X-G motif; other site 931276012540 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276012541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276012542 active site 931276012543 phosphorylation site [posttranslational modification] 931276012544 intermolecular recognition site; other site 931276012545 dimerization interface [polypeptide binding]; other site 931276012546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276012547 DNA binding site [nucleotide binding] 931276012548 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 931276012549 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 931276012550 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 931276012551 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 931276012552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276012553 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276012554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276012555 dimerization interface [polypeptide binding]; other site 931276012556 putative DNA binding site [nucleotide binding]; other site 931276012557 putative Zn2+ binding site [ion binding]; other site 931276012558 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 931276012559 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931276012560 catalytic loop [active] 931276012561 iron binding site [ion binding]; other site 931276012562 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 931276012563 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931276012564 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276012565 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931276012566 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 931276012567 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 931276012568 [2Fe-2S] cluster binding site [ion binding]; other site 931276012569 dimer interface [polypeptide binding]; other site 931276012570 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 931276012571 SLBB domain; Region: SLBB; pfam10531 931276012572 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 931276012573 4Fe-4S binding domain; Region: Fer4; pfam00037 931276012574 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931276012575 4Fe-4S binding domain; Region: Fer4; pfam00037 931276012576 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 931276012577 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 931276012578 putative dimer interface [polypeptide binding]; other site 931276012579 [2Fe-2S] cluster binding site [ion binding]; other site 931276012580 alanine racemase; Reviewed; Region: alr; PRK00053 931276012581 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 931276012582 active site 931276012583 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931276012584 dimer interface [polypeptide binding]; other site 931276012585 substrate binding site [chemical binding]; other site 931276012586 catalytic residues [active] 931276012587 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 931276012588 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276012589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276012590 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276012591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276012592 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 931276012593 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 931276012594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276012595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276012596 DNA binding residues [nucleotide binding] 931276012597 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 931276012598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276012599 putative substrate translocation pore; other site 931276012600 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 931276012601 Dynamin family; Region: Dynamin_N; pfam00350 931276012602 G1 box; other site 931276012603 GTP/Mg2+ binding site [chemical binding]; other site 931276012604 G2 box; other site 931276012605 Switch I region; other site 931276012606 G3 box; other site 931276012607 Switch II region; other site 931276012608 Dynamin family; Region: Dynamin_N; pfam00350 931276012609 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 931276012610 GTP/Mg2+ binding site [chemical binding]; other site 931276012611 G1 box; other site 931276012612 G2 box; other site 931276012613 Switch I region; other site 931276012614 G3 box; other site 931276012615 Switch II region; other site 931276012616 G4 box; other site 931276012617 G5 box; other site 931276012618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276012619 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 931276012620 Dynamin family; Region: Dynamin_N; pfam00350 931276012621 G1 box; other site 931276012622 Walker A/P-loop; other site 931276012623 GTP/Mg2+ binding site [chemical binding]; other site 931276012624 ATP binding site [chemical binding]; other site 931276012625 G2 box; other site 931276012626 Switch I region; other site 931276012627 G3 box; other site 931276012628 Switch II region; other site 931276012629 G4 box; other site 931276012630 G5 box; other site 931276012631 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 931276012632 classical (c) SDRs; Region: SDR_c; cd05233 931276012633 NAD(P) binding site [chemical binding]; other site 931276012634 active site 931276012635 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 931276012636 Ferritin-like domain; Region: Ferritin; pfam00210 931276012637 ferroxidase diiron center [ion binding]; other site 931276012638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276012639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276012640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276012641 dimerization interface [polypeptide binding]; other site 931276012642 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931276012643 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276012644 active site 931276012645 FMN binding site [chemical binding]; other site 931276012646 substrate binding site [chemical binding]; other site 931276012647 putative catalytic residue [active] 931276012648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276012649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276012650 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 931276012651 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 931276012652 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 931276012653 enolase; Provisional; Region: eno; PRK00077 931276012654 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 931276012655 dimer interface [polypeptide binding]; other site 931276012656 metal binding site [ion binding]; metal-binding site 931276012657 substrate binding pocket [chemical binding]; other site 931276012658 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 931276012659 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 931276012660 HSP70 interaction site [polypeptide binding]; other site 931276012661 Tetratricopeptide repeat; Region: TPR_16; pfam13432 931276012662 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 931276012663 active site 931276012664 domain interfaces; other site 931276012665 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 931276012666 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 931276012667 Multicopper oxidase; Region: Cu-oxidase; pfam00394 931276012668 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 931276012669 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 931276012670 FAD binding domain; Region: FAD_binding_4; pfam01565 931276012671 Berberine and berberine like; Region: BBE; pfam08031 931276012672 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276012673 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276012674 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 931276012675 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276012676 active site 931276012677 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931276012678 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 931276012679 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 931276012680 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 931276012681 Hpr binding site; other site 931276012682 active site 931276012683 homohexamer subunit interaction site [polypeptide binding]; other site 931276012684 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 931276012685 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 931276012686 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 931276012687 isocitrate dehydrogenase; Validated; Region: PRK08299 931276012688 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931276012689 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 931276012690 aconitate hydratase; Validated; Region: PRK07229 931276012691 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 931276012692 substrate binding site [chemical binding]; other site 931276012693 ligand binding site [chemical binding]; other site 931276012694 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 931276012695 substrate binding site [chemical binding]; other site 931276012696 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 931276012697 Citrate transporter; Region: CitMHS; pfam03600 931276012698 Propionate catabolism activator; Region: PrpR_N; pfam06506 931276012699 PAS domain; Region: PAS; smart00091 931276012700 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 931276012701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276012702 Walker A motif; other site 931276012703 ATP binding site [chemical binding]; other site 931276012704 Walker B motif; other site 931276012705 arginine finger; other site 931276012706 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276012707 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 931276012708 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 931276012709 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 931276012710 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 931276012711 citrate lyase subunit gamma; Provisional; Region: PRK13253 931276012712 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 931276012713 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276012714 active site 931276012715 nucleotide binding site [chemical binding]; other site 931276012716 HIGH motif; other site 931276012717 KMSKS motif; other site 931276012718 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 931276012719 Malic enzyme, N-terminal domain; Region: malic; pfam00390 931276012720 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 931276012721 putative NAD(P) binding site [chemical binding]; other site 931276012722 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 931276012723 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 931276012724 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 931276012725 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 931276012726 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 931276012727 active site 931276012728 substrate-binding site [chemical binding]; other site 931276012729 metal-binding site [ion binding] 931276012730 ATP binding site [chemical binding]; other site 931276012731 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 931276012732 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 931276012733 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 931276012734 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 931276012735 CAAX protease self-immunity; Region: Abi; pfam02517 931276012736 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 931276012737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276012738 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 931276012739 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 931276012740 active site 931276012741 dimer interface [polypeptide binding]; other site 931276012742 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 931276012743 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 931276012744 active site 931276012745 FMN binding site [chemical binding]; other site 931276012746 substrate binding site [chemical binding]; other site 931276012747 3Fe-4S cluster binding site [ion binding]; other site 931276012748 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 931276012749 domain interface; other site 931276012750 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 931276012751 ANTAR domain; Region: ANTAR; pfam03861 931276012752 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 931276012753 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 931276012754 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 931276012755 aspartate kinase; Reviewed; Region: PRK09034 931276012756 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 931276012757 nucleotide binding site [chemical binding]; other site 931276012758 substrate binding site [chemical binding]; other site 931276012759 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 931276012760 allosteric regulatory residue; other site 931276012761 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 931276012762 Condensation domain; Region: Condensation; pfam00668 931276012763 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276012764 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 931276012765 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 931276012766 acyl-activating enzyme (AAE) consensus motif; other site 931276012767 AMP binding site [chemical binding]; other site 931276012768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276012769 Condensation domain; Region: Condensation; pfam00668 931276012770 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 931276012771 Condensation domain; Region: Condensation; pfam00668 931276012772 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 931276012773 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 931276012774 acyl-activating enzyme (AAE) consensus motif; other site 931276012775 AMP binding site [chemical binding]; other site 931276012776 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276012777 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 931276012778 FtsX-like permease family; Region: FtsX; pfam02687 931276012779 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276012780 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931276012781 Walker A/P-loop; other site 931276012782 ATP binding site [chemical binding]; other site 931276012783 Q-loop/lid; other site 931276012784 ABC transporter signature motif; other site 931276012785 Walker B; other site 931276012786 D-loop; other site 931276012787 H-loop/switch region; other site 931276012788 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 931276012789 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276012790 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276012791 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 931276012792 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 931276012793 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276012794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276012795 metal binding site [ion binding]; metal-binding site 931276012796 active site 931276012797 I-site; other site 931276012798 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 931276012799 metal ion-dependent adhesion site (MIDAS); other site 931276012800 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 931276012801 metal ion-dependent adhesion site (MIDAS); other site 931276012802 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 931276012803 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 931276012804 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 931276012805 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931276012806 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931276012807 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 931276012808 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 931276012809 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 931276012810 Walker A motif; other site 931276012811 ATP binding site [chemical binding]; other site 931276012812 Walker B motif; other site 931276012813 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 931276012814 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 931276012815 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 931276012816 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931276012817 Walker A motif; other site 931276012818 ATP binding site [chemical binding]; other site 931276012819 Walker B motif; other site 931276012820 Hemerythrin; Region: Hemerythrin; cd12107 931276012821 Fe binding site [ion binding]; other site 931276012822 Hemerythrin; Region: Hemerythrin; cd12107 931276012823 Fe binding site [ion binding]; other site 931276012824 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276012825 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 931276012826 active site 931276012827 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276012828 putative transposase OrfB; Reviewed; Region: PHA02517 931276012829 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931276012830 Integrase core domain; Region: rve; pfam00665 931276012831 Integrase core domain; Region: rve_3; cl15866 931276012832 Transposase; Region: HTH_Tnp_1; cl17663 931276012833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931276012834 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276012835 active site 931276012836 DNA binding site [nucleotide binding] 931276012837 Int/Topo IB signature motif; other site 931276012838 hypothetical protein; Validated; Region: PRK00110 931276012839 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931276012840 GAF domain; Region: GAF_3; pfam13492 931276012841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276012842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276012843 metal binding site [ion binding]; metal-binding site 931276012844 active site 931276012845 I-site; other site 931276012846 Uncharacterized conserved protein [Function unknown]; Region: COG1739 931276012847 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 931276012848 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 931276012849 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931276012850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276012851 DNA-binding site [nucleotide binding]; DNA binding site 931276012852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276012853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276012854 homodimer interface [polypeptide binding]; other site 931276012855 catalytic residue [active] 931276012856 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 931276012857 active site 931276012858 NTP binding site [chemical binding]; other site 931276012859 metal binding triad [ion binding]; metal-binding site 931276012860 antibiotic binding site [chemical binding]; other site 931276012861 GTPases [General function prediction only]; Region: HflX; COG2262 931276012862 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 931276012863 HflX GTPase family; Region: HflX; cd01878 931276012864 G1 box; other site 931276012865 GTP/Mg2+ binding site [chemical binding]; other site 931276012866 Switch I region; other site 931276012867 G2 box; other site 931276012868 G3 box; other site 931276012869 Switch II region; other site 931276012870 G4 box; other site 931276012871 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931276012872 active site 931276012873 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 931276012874 Transglycosylase; Region: Transgly; pfam00912 931276012875 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 931276012876 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 931276012877 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 931276012878 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 931276012879 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931276012880 DNA binding residues [nucleotide binding] 931276012881 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 931276012882 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931276012883 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276012884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276012885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276012886 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 931276012887 putative dimerization interface [polypeptide binding]; other site 931276012888 Predicted membrane protein [Function unknown]; Region: COG2855 931276012889 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 931276012890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 931276012891 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 931276012892 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931276012893 Cation efflux family; Region: Cation_efflux; pfam01545 931276012894 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 931276012895 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931276012896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276012897 S-adenosylmethionine binding site [chemical binding]; other site 931276012898 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 931276012899 active site 931276012900 multimer interface [polypeptide binding]; other site 931276012901 Acylphosphatase; Region: Acylphosphatase; cl00551 931276012902 putative hydrolase; Validated; Region: PRK09248 931276012903 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 931276012904 active site 931276012905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276012906 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276012907 active site 931276012908 motif I; other site 931276012909 motif II; other site 931276012910 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276012911 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 931276012912 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931276012913 Probable Catalytic site; other site 931276012914 metal-binding site 931276012915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276012916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276012917 S-adenosylmethionine binding site [chemical binding]; other site 931276012918 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931276012919 active site 931276012920 DNA polymerase IV; Provisional; Region: PRK14133 931276012921 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 931276012922 active site 931276012923 DNA binding site [nucleotide binding] 931276012924 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 931276012925 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931276012926 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 931276012927 flagellin; Provisional; Region: PRK12804 931276012928 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 931276012929 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 931276012930 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 931276012931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276012932 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 931276012933 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931276012934 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931276012935 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 931276012936 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931276012937 DRTGG domain; Region: DRTGG; pfam07085 931276012938 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 931276012939 DHHA2 domain; Region: DHHA2; pfam02833 931276012940 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 931276012941 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931276012942 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 931276012943 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931276012944 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 931276012945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276012946 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 931276012947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276012948 DNA binding residues [nucleotide binding] 931276012949 Flagellar protein YcgR; Region: YcgR_2; pfam12945 931276012950 PilZ domain; Region: PilZ; pfam07238 931276012951 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 931276012952 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 931276012953 P-loop; other site 931276012954 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 931276012955 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 931276012956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931276012957 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 931276012958 FHIPEP family; Region: FHIPEP; pfam00771 931276012959 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 931276012960 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 931276012961 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 931276012962 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 931276012963 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 931276012964 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 931276012965 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 931276012966 Flagellar protein (FlbD); Region: FlbD; pfam06289 931276012967 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 931276012968 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 931276012969 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 931276012970 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931276012971 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 931276012972 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 931276012973 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 931276012974 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 931276012975 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 931276012976 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 931276012977 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 931276012978 Walker A motif/ATP binding site; other site 931276012979 Walker B motif; other site 931276012980 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 931276012981 Flagellar assembly protein FliH; Region: FliH; pfam02108 931276012982 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 931276012983 FliG C-terminal domain; Region: FliG_C; pfam01706 931276012984 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 931276012985 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 931276012986 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 931276012987 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 931276012988 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 931276012989 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 931276012990 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931276012991 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 931276012992 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 931276012993 flagellin; Provisional; Region: PRK12804 931276012994 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931276012995 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 931276012996 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 931276012997 active site 931276012998 catalytic triad [active] 931276012999 oxyanion hole [active] 931276013000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 931276013001 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 931276013002 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276013003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276013004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276013005 pseudaminic acid synthase; Region: PseI; TIGR03586 931276013006 NeuB family; Region: NeuB; pfam03102 931276013007 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 931276013008 NeuB binding interface [polypeptide binding]; other site 931276013009 putative substrate binding site [chemical binding]; other site 931276013010 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276013011 UDP-galactopyranose mutase; Region: GLF; pfam03275 931276013012 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 931276013013 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 931276013014 ligand binding site; other site 931276013015 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 931276013016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276013017 motif II; other site 931276013018 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 931276013019 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 931276013020 nudix motif; other site 931276013021 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276013022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276013023 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276013024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276013025 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931276013026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276013027 S-adenosylmethionine binding site [chemical binding]; other site 931276013028 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 931276013029 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 931276013030 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 931276013031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276013032 active site 931276013033 Phosphotransferase enzyme family; Region: APH; pfam01636 931276013034 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 931276013035 Cupin domain; Region: Cupin_2; cl17218 931276013036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276013037 active site 931276013038 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 931276013039 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276013040 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276013041 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 931276013042 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 931276013043 trimer interface [polypeptide binding]; other site 931276013044 active site 931276013045 substrate binding site [chemical binding]; other site 931276013046 CoA binding site [chemical binding]; other site 931276013047 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 931276013048 putative ligand binding site [chemical binding]; other site 931276013049 putative catalytic site [active] 931276013050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276013051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276013052 active site 931276013053 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 931276013054 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276013055 active site 931276013056 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 931276013057 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 931276013058 Ligand binding site; other site 931276013059 metal-binding site 931276013060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931276013061 active site 931276013062 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 931276013063 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 931276013064 putative active site [active] 931276013065 DltD C-terminal region; Region: DltD_C; pfam04914 931276013066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276013067 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 931276013068 active site 931276013069 Phosphotransferase enzyme family; Region: APH; pfam01636 931276013070 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 931276013071 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 931276013072 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 931276013073 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 931276013074 NAD(P) binding site [chemical binding]; other site 931276013075 homodimer interface [polypeptide binding]; other site 931276013076 substrate binding site [chemical binding]; other site 931276013077 active site 931276013078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 931276013079 flagellin; Provisional; Region: PRK12804 931276013080 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931276013081 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 931276013082 Flagellar protein FliT; Region: FliT; pfam05400 931276013083 flagellar capping protein; Validated; Region: fliD; PRK07737 931276013084 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 931276013085 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 931276013086 FlaG protein; Region: FlaG; pfam03646 931276013087 carbon storage regulator; Provisional; Region: PRK01712 931276013088 flagellar assembly protein FliW; Provisional; Region: PRK13285 931276013089 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 931276013090 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931276013091 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 931276013092 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931276013093 FlgN protein; Region: FlgN; pfam05130 931276013094 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 931276013095 V-type ATP synthase subunit I; Validated; Region: PRK05771 931276013096 flagellar motor switch protein; Validated; Region: PRK08119 931276013097 CheC-like family; Region: CheC; pfam04509 931276013098 CheC-like family; Region: CheC; pfam04509 931276013099 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 931276013100 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 931276013101 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 931276013102 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931276013103 Response regulator receiver domain; Region: Response_reg; pfam00072 931276013104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276013105 active site 931276013106 phosphorylation site [posttranslational modification] 931276013107 intermolecular recognition site; other site 931276013108 dimerization interface [polypeptide binding]; other site 931276013109 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 931276013110 CheC-like family; Region: CheC; pfam04509 931276013111 CheC-like family; Region: CheC; pfam04509 931276013112 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 931276013113 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931276013114 putative binding surface; other site 931276013115 active site 931276013116 P2 response regulator binding domain; Region: P2; pfam07194 931276013117 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 931276013118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276013119 ATP binding site [chemical binding]; other site 931276013120 Mg2+ binding site [ion binding]; other site 931276013121 G-X-G motif; other site 931276013122 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 931276013123 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 931276013124 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 931276013125 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 931276013126 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 931276013127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276013128 active site 931276013129 phosphorylation site [posttranslational modification] 931276013130 intermolecular recognition site; other site 931276013131 dimerization interface [polypeptide binding]; other site 931276013132 CheB methylesterase; Region: CheB_methylest; pfam01339 931276013133 CheD chemotactic sensory transduction; Region: CheD; cl00810 931276013134 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931276013135 Uncharacterized conserved protein [Function unknown]; Region: COG1315 931276013136 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 931276013137 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 931276013138 substrate-cofactor binding pocket; other site 931276013139 homodimer interface [polypeptide binding]; other site 931276013140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276013141 catalytic residue [active] 931276013142 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 931276013143 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276013144 aspartate aminotransferase; Provisional; Region: PRK05764 931276013145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276013146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276013147 homodimer interface [polypeptide binding]; other site 931276013148 catalytic residue [active] 931276013149 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 931276013150 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 931276013151 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 931276013152 dimer interface [polypeptide binding]; other site 931276013153 PYR/PP interface [polypeptide binding]; other site 931276013154 TPP binding site [chemical binding]; other site 931276013155 substrate binding site [chemical binding]; other site 931276013156 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276013157 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 931276013158 Domain of unknown function; Region: EKR; smart00890 931276013159 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931276013160 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276013161 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 931276013162 TPP-binding site [chemical binding]; other site 931276013163 dimer interface [polypeptide binding]; other site 931276013164 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931276013165 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 931276013166 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 931276013167 active site 931276013168 homodimer interface [polypeptide binding]; other site 931276013169 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 931276013170 DHH family; Region: DHH; pfam01368 931276013171 DHHA1 domain; Region: DHHA1; pfam02272 931276013172 DJ-1 family protein; Region: not_thiJ; TIGR01383 931276013173 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 931276013174 conserved cys residue [active] 931276013175 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 931276013176 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 931276013177 CAP-like domain; other site 931276013178 active site 931276013179 primary dimer interface [polypeptide binding]; other site 931276013180 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931276013181 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 931276013182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276013183 ATP binding site [chemical binding]; other site 931276013184 Mg2+ binding site [ion binding]; other site 931276013185 G-X-G motif; other site 931276013186 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 931276013187 anchoring element; other site 931276013188 dimer interface [polypeptide binding]; other site 931276013189 ATP binding site [chemical binding]; other site 931276013190 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 931276013191 active site 931276013192 metal binding site [ion binding]; metal-binding site 931276013193 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 931276013194 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 931276013195 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 931276013196 DXD motif; other site 931276013197 Rhomboid family; Region: Rhomboid; pfam01694 931276013198 oligoendopeptidase F; Region: pepF; TIGR00181 931276013199 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 931276013200 active site 931276013201 Zn binding site [ion binding]; other site 931276013202 Phosphopantetheine attachment site; Region: PP-binding; cl09936 931276013203 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 931276013204 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 931276013205 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 931276013206 acyl-activating enzyme (AAE) consensus motif; other site 931276013207 AMP binding site [chemical binding]; other site 931276013208 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 931276013209 DltD central region; Region: DltD_M; pfam04918 931276013210 DltD C-terminal region; Region: DltD_C; pfam04914 931276013211 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931276013212 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 931276013213 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 931276013214 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931276013215 ABC-ATPase subunit interface; other site 931276013216 dimer interface [polypeptide binding]; other site 931276013217 putative PBP binding regions; other site 931276013218 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931276013219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276013220 catalytic residue [active] 931276013221 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931276013222 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 931276013223 PYR/PP interface [polypeptide binding]; other site 931276013224 dimer interface [polypeptide binding]; other site 931276013225 TPP binding site [chemical binding]; other site 931276013226 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 931276013227 TPP-binding site; other site 931276013228 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276013229 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 931276013230 active site 931276013231 nucleotide binding site [chemical binding]; other site 931276013232 HIGH motif; other site 931276013233 KMSKS motif; other site 931276013234 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 931276013235 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 931276013236 tetramer interface [polypeptide binding]; other site 931276013237 active site 931276013238 Mg2+/Mn2+ binding site [ion binding]; other site 931276013239 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 931276013240 active site 931276013241 metal-binding site 931276013242 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 931276013243 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276013244 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931276013245 Walker A/P-loop; other site 931276013246 ATP binding site [chemical binding]; other site 931276013247 Q-loop/lid; other site 931276013248 ABC transporter signature motif; other site 931276013249 Walker B; other site 931276013250 D-loop; other site 931276013251 H-loop/switch region; other site 931276013252 Predicted transcriptional regulators [Transcription]; Region: COG1725 931276013253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276013254 DNA-binding site [nucleotide binding]; DNA binding site 931276013255 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 931276013256 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 931276013257 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 931276013258 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 931276013259 putative active site [active] 931276013260 Zn binding site [ion binding]; other site 931276013261 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 931276013262 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 931276013263 putative active site [active] 931276013264 Zn binding site [ion binding]; other site 931276013265 Cache domain; Region: Cache_1; pfam02743 931276013266 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276013267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276013268 dimer interface [polypeptide binding]; other site 931276013269 putative CheW interface [polypeptide binding]; other site 931276013270 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 931276013271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931276013272 inhibitor-cofactor binding pocket; inhibition site 931276013273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276013274 catalytic residue [active] 931276013275 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 931276013276 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276013277 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 931276013278 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 931276013279 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276013280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 931276013281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276013282 ABC-ATPase subunit interface; other site 931276013283 putative PBP binding loops; other site 931276013284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276013285 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276013286 substrate binding pocket [chemical binding]; other site 931276013287 membrane-bound complex binding site; other site 931276013288 hinge residues; other site 931276013289 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276013290 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276013291 Walker A/P-loop; other site 931276013292 ATP binding site [chemical binding]; other site 931276013293 Q-loop/lid; other site 931276013294 ABC transporter signature motif; other site 931276013295 Walker B; other site 931276013296 D-loop; other site 931276013297 H-loop/switch region; other site 931276013298 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 931276013299 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 931276013300 putative active site [active] 931276013301 metal binding site [ion binding]; metal-binding site 931276013302 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931276013303 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931276013304 dimer interface [polypeptide binding]; other site 931276013305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276013306 catalytic residue [active] 931276013307 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 931276013308 putative FMN binding site [chemical binding]; other site 931276013309 Hemerythrin; Region: Hemerythrin; cd12107 931276013310 Fe binding site [ion binding]; other site 931276013311 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 931276013312 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 931276013313 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 931276013314 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 931276013315 dimer interface [polypeptide binding]; other site 931276013316 active site 931276013317 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931276013318 catalytic residues [active] 931276013319 substrate binding site [chemical binding]; other site 931276013320 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 931276013321 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 931276013322 NAD(P) binding pocket [chemical binding]; other site 931276013323 spermidine synthase; Provisional; Region: PRK00811 931276013324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276013325 S-adenosylmethionine binding site [chemical binding]; other site 931276013326 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 931276013327 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 931276013328 homodimer interface [polypeptide binding]; other site 931276013329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276013330 catalytic residue [active] 931276013331 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 931276013332 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 931276013333 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 931276013334 Coat F domain; Region: Coat_F; pfam07875 931276013335 Cache domain; Region: Cache_1; pfam02743 931276013336 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276013337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276013338 dimer interface [polypeptide binding]; other site 931276013339 putative CheW interface [polypeptide binding]; other site 931276013340 galactokinase; Provisional; Region: PRK05322 931276013341 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 931276013342 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 931276013343 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 931276013344 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 931276013345 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 931276013346 NAD binding site [chemical binding]; other site 931276013347 homodimer interface [polypeptide binding]; other site 931276013348 active site 931276013349 substrate binding site [chemical binding]; other site 931276013350 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 931276013351 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 931276013352 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 931276013353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276013354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276013355 DNA binding site [nucleotide binding] 931276013356 domain linker motif; other site 931276013357 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276013358 dimerization interface [polypeptide binding]; other site 931276013359 ligand binding site [chemical binding]; other site 931276013360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276013361 dimer interface [polypeptide binding]; other site 931276013362 putative CheW interface [polypeptide binding]; other site 931276013363 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 931276013364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276013365 FeS/SAM binding site; other site 931276013366 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 931276013367 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 931276013368 active site clefts [active] 931276013369 zinc binding site [ion binding]; other site 931276013370 dimer interface [polypeptide binding]; other site 931276013371 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 931276013372 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276013373 ligand binding site [chemical binding]; other site 931276013374 calcium binding site [ion binding]; other site 931276013375 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 931276013376 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276013377 Cache domain; Region: Cache_1; pfam02743 931276013378 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931276013379 HAMP domain; Region: HAMP; pfam00672 931276013380 dimerization interface [polypeptide binding]; other site 931276013381 Histidine kinase; Region: His_kinase; pfam06580 931276013382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276013383 ATP binding site [chemical binding]; other site 931276013384 Mg2+ binding site [ion binding]; other site 931276013385 G-X-G motif; other site 931276013386 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 931276013387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276013388 active site 931276013389 phosphorylation site [posttranslational modification] 931276013390 intermolecular recognition site; other site 931276013391 dimerization interface [polypeptide binding]; other site 931276013392 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276013393 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276013394 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276013395 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 931276013396 TM-ABC transporter signature motif; other site 931276013397 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 931276013398 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 931276013399 Walker A/P-loop; other site 931276013400 ATP binding site [chemical binding]; other site 931276013401 Q-loop/lid; other site 931276013402 ABC transporter signature motif; other site 931276013403 Walker B; other site 931276013404 D-loop; other site 931276013405 H-loop/switch region; other site 931276013406 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 931276013407 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 931276013408 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 931276013409 ligand binding site [chemical binding]; other site 931276013410 calcium binding site [ion binding]; other site 931276013411 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 931276013412 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 931276013413 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 931276013414 EDD domain protein, DegV family; Region: DegV; TIGR00762 931276013415 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931276013416 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 931276013417 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931276013418 TPP-binding site [chemical binding]; other site 931276013419 dimer interface [polypeptide binding]; other site 931276013420 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276013421 PYR/PP interface [polypeptide binding]; other site 931276013422 dimer interface [polypeptide binding]; other site 931276013423 TPP binding site [chemical binding]; other site 931276013424 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276013425 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 931276013426 intersubunit interface [polypeptide binding]; other site 931276013427 active site 931276013428 catalytic residue [active] 931276013429 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 931276013430 active site 931276013431 intersubunit interactions; other site 931276013432 catalytic residue [active] 931276013433 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276013434 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 931276013435 TM-ABC transporter signature motif; other site 931276013436 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276013437 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 931276013438 TM-ABC transporter signature motif; other site 931276013439 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 931276013440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276013441 Walker A/P-loop; other site 931276013442 ATP binding site [chemical binding]; other site 931276013443 Q-loop/lid; other site 931276013444 ABC transporter signature motif; other site 931276013445 Walker B; other site 931276013446 D-loop; other site 931276013447 H-loop/switch region; other site 931276013448 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 931276013449 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 931276013450 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 931276013451 ligand binding site [chemical binding]; other site 931276013452 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 931276013453 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 931276013454 Predicted membrane protein [Function unknown]; Region: COG2364 931276013455 phosphopentomutase; Provisional; Region: PRK05362 931276013456 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 931276013457 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 931276013458 active site 931276013459 catalytic motif [active] 931276013460 Zn binding site [ion binding]; other site 931276013461 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 931276013462 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 931276013463 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931276013464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276013465 DNA-binding site [nucleotide binding]; DNA binding site 931276013466 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 931276013467 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931276013468 TPP-binding site [chemical binding]; other site 931276013469 dimer interface [polypeptide binding]; other site 931276013470 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276013471 PYR/PP interface [polypeptide binding]; other site 931276013472 dimer interface [polypeptide binding]; other site 931276013473 TPP binding site [chemical binding]; other site 931276013474 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276013475 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 931276013476 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 931276013477 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276013478 TM-ABC transporter signature motif; other site 931276013479 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 931276013480 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 931276013481 Walker A/P-loop; other site 931276013482 ATP binding site [chemical binding]; other site 931276013483 Q-loop/lid; other site 931276013484 ABC transporter signature motif; other site 931276013485 Walker B; other site 931276013486 D-loop; other site 931276013487 H-loop/switch region; other site 931276013488 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 931276013489 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 931276013490 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 931276013491 putative ligand binding site [chemical binding]; other site 931276013492 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 931276013493 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931276013494 putative N- and C-terminal domain interface [polypeptide binding]; other site 931276013495 putative active site [active] 931276013496 MgATP binding site [chemical binding]; other site 931276013497 catalytic site [active] 931276013498 metal binding site [ion binding]; metal-binding site 931276013499 putative carbohydrate binding site [chemical binding]; other site 931276013500 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 931276013501 active site 931276013502 intersubunit interactions; other site 931276013503 catalytic residue [active] 931276013504 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 931276013505 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 931276013506 intersubunit interface [polypeptide binding]; other site 931276013507 active site 931276013508 Zn2+ binding site [ion binding]; other site 931276013509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276013510 DNA-binding site [nucleotide binding]; DNA binding site 931276013511 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276013512 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 931276013513 putative dimerization interface [polypeptide binding]; other site 931276013514 putative ligand binding site [chemical binding]; other site 931276013515 L-arabinose isomerase; Provisional; Region: PRK02929 931276013516 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 931276013517 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 931276013518 trimer interface [polypeptide binding]; other site 931276013519 putative substrate binding site [chemical binding]; other site 931276013520 putative metal binding site [ion binding]; other site 931276013521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276013522 dimerization interface [polypeptide binding]; other site 931276013523 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931276013524 Histidine kinase; Region: His_kinase; pfam06580 931276013525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276013526 ATP binding site [chemical binding]; other site 931276013527 Mg2+ binding site [ion binding]; other site 931276013528 G-X-G motif; other site 931276013529 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276013530 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 931276013531 TM-ABC transporter signature motif; other site 931276013532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276013533 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 931276013534 TM-ABC transporter signature motif; other site 931276013535 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 931276013536 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 931276013537 Walker A/P-loop; other site 931276013538 ATP binding site [chemical binding]; other site 931276013539 Q-loop/lid; other site 931276013540 ABC transporter signature motif; other site 931276013541 Walker B; other site 931276013542 D-loop; other site 931276013543 H-loop/switch region; other site 931276013544 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 931276013545 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 931276013546 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 931276013547 putative ligand binding site [chemical binding]; other site 931276013548 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 931276013549 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 931276013550 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 931276013551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276013552 active site 931276013553 phosphorylation site [posttranslational modification] 931276013554 intermolecular recognition site; other site 931276013555 dimerization interface [polypeptide binding]; other site 931276013556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276013557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276013558 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 931276013559 active site 931276013560 catalytic residues [active] 931276013561 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 931276013562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276013563 active site 931276013564 motif I; other site 931276013565 motif II; other site 931276013566 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276013567 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276013568 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276013569 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276013570 active site 931276013571 P-loop; other site 931276013572 phosphorylation site [posttranslational modification] 931276013573 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 931276013574 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 931276013575 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 931276013576 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931276013577 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931276013578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276013579 active site 931276013580 phosphorylation site [posttranslational modification] 931276013581 intermolecular recognition site; other site 931276013582 dimerization interface [polypeptide binding]; other site 931276013583 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 931276013584 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 931276013585 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 931276013586 dimanganese center [ion binding]; other site 931276013587 CHASE3 domain; Region: CHASE3; cl05000 931276013588 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276013589 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276013590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276013591 dimerization interface [polypeptide binding]; other site 931276013592 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276013593 dimer interface [polypeptide binding]; other site 931276013594 putative CheW interface [polypeptide binding]; other site 931276013595 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 931276013596 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 931276013597 inner membrane transporter YjeM; Provisional; Region: PRK15238 931276013598 Rubredoxin; Region: Rubredoxin; pfam00301 931276013599 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 931276013600 iron binding site [ion binding]; other site 931276013601 AAA domain; Region: AAA_22; pfam13401 931276013602 AAA ATPase domain; Region: AAA_16; pfam13191 931276013603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276013604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276013605 DNA binding residues [nucleotide binding] 931276013606 dimerization interface [polypeptide binding]; other site 931276013607 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931276013608 ABC-2 type transporter; Region: ABC2_membrane; cl17235 931276013609 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931276013610 ABC-2 type transporter; Region: ABC2_membrane; cl17235 931276013611 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276013612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276013613 Walker A/P-loop; other site 931276013614 ATP binding site [chemical binding]; other site 931276013615 Q-loop/lid; other site 931276013616 ABC transporter signature motif; other site 931276013617 Walker B; other site 931276013618 D-loop; other site 931276013619 H-loop/switch region; other site 931276013620 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 931276013621 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 931276013622 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276013623 active site 931276013624 HIGH motif; other site 931276013625 nucleotide binding site [chemical binding]; other site 931276013626 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 931276013627 KMSK motif region; other site 931276013628 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 931276013629 tRNA binding surface [nucleotide binding]; other site 931276013630 anticodon binding site; other site 931276013631 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 931276013632 transcription elongation factor GreA; Region: greA; TIGR01462 931276013633 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 931276013634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931276013635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276013636 non-specific DNA binding site [nucleotide binding]; other site 931276013637 salt bridge; other site 931276013638 sequence-specific DNA binding site [nucleotide binding]; other site 931276013639 transcriptional antiterminator BglG; Provisional; Region: PRK09772 931276013640 PRD domain; Region: PRD; pfam00874 931276013641 PRD domain; Region: PRD; pfam00874 931276013642 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276013643 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 931276013644 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276013645 active site turn [active] 931276013646 phosphorylation site [posttranslational modification] 931276013647 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931276013648 HPr interaction site; other site 931276013649 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276013650 active site 931276013651 phosphorylation site [posttranslational modification] 931276013652 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 931276013653 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 931276013654 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 931276013655 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 931276013656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276013657 FeS/SAM binding site; other site 931276013658 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 931276013659 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 931276013660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276013661 FeS/SAM binding site; other site 931276013662 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 931276013663 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276013664 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276013665 Outer membrane efflux protein; Region: OEP; pfam02321 931276013666 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 931276013667 Protein export membrane protein; Region: SecD_SecF; cl14618 931276013668 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276013669 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276013670 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276013671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 931276013672 Histidine kinase; Region: HisKA_3; pfam07730 931276013673 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 931276013674 Mg2+ binding site [ion binding]; other site 931276013675 G-X-G motif; other site 931276013676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276013677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276013678 active site 931276013679 phosphorylation site [posttranslational modification] 931276013680 intermolecular recognition site; other site 931276013681 dimerization interface [polypeptide binding]; other site 931276013682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276013683 dimerization interface [polypeptide binding]; other site 931276013684 DNA binding residues [nucleotide binding] 931276013685 DHH family; Region: DHH; pfam01368 931276013686 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 931276013687 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 931276013688 active site 931276013689 intersubunit interactions; other site 931276013690 catalytic residue [active] 931276013691 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 931276013692 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 931276013693 dimer interface [polypeptide binding]; other site 931276013694 active site 931276013695 glycine loop; other site 931276013696 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931276013697 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 931276013698 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931276013699 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 931276013700 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276013701 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 931276013702 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931276013703 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931276013704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276013705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276013706 putative substrate translocation pore; other site 931276013707 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276013708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276013709 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276013710 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276013711 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276013712 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276013713 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276013714 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931276013715 Metal-binding active site; metal-binding site 931276013716 Predicted oxidoreductase [General function prediction only]; Region: COG3573 931276013717 hypothetical protein; Validated; Region: PRK07121 931276013718 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276013719 putative CheW interface [polypeptide binding]; other site 931276013720 Nitroreductase family; Region: Nitroreductase; pfam00881 931276013721 FMN binding site [chemical binding]; other site 931276013722 dimer interface [polypeptide binding]; other site 931276013723 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 931276013724 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931276013725 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276013726 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276013727 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276013728 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276013729 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 931276013730 SLBB domain; Region: SLBB; pfam10531 931276013731 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 931276013732 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276013733 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276013734 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931276013735 catalytic loop [active] 931276013736 iron binding site [ion binding]; other site 931276013737 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 931276013738 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931276013739 4Fe-4S binding domain; Region: Fer4; pfam00037 931276013740 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 931276013741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276013742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276013743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276013744 DNA binding site [nucleotide binding] 931276013745 domain linker motif; other site 931276013746 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276013747 ligand binding site [chemical binding]; other site 931276013748 dimerization interface [polypeptide binding]; other site 931276013749 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 931276013750 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 931276013751 putative ligand binding site [chemical binding]; other site 931276013752 putative NAD binding site [chemical binding]; other site 931276013753 catalytic site [active] 931276013754 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931276013755 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 931276013756 N- and C-terminal domain interface [polypeptide binding]; other site 931276013757 putative active site [active] 931276013758 MgATP binding site [chemical binding]; other site 931276013759 catalytic site [active] 931276013760 metal binding site [ion binding]; metal-binding site 931276013761 putative xylulose binding site [chemical binding]; other site 931276013762 putative homodimer interface [polypeptide binding]; other site 931276013763 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931276013764 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276013765 active site 931276013766 FMN binding site [chemical binding]; other site 931276013767 substrate binding site [chemical binding]; other site 931276013768 putative catalytic residue [active] 931276013769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276013770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276013771 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931276013772 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931276013773 active site 931276013774 NAD binding site [chemical binding]; other site 931276013775 metal binding site [ion binding]; metal-binding site 931276013776 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 931276013777 intersubunit interface [polypeptide binding]; other site 931276013778 active site 931276013779 Zn2+ binding site [ion binding]; other site 931276013780 HTH domain; Region: HTH_11; pfam08279 931276013781 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 931276013782 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 931276013783 active site 931276013784 phosphorylation site [posttranslational modification] 931276013785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276013786 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276013787 putative substrate translocation pore; other site 931276013788 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931276013789 MFS/sugar transport protein; Region: MFS_2; pfam13347 931276013790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276013791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276013792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276013793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276013794 putative substrate translocation pore; other site 931276013795 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931276013796 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276013797 active site 931276013798 FMN binding site [chemical binding]; other site 931276013799 substrate binding site [chemical binding]; other site 931276013800 putative catalytic residue [active] 931276013801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276013802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276013803 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 931276013804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276013805 putative substrate translocation pore; other site 931276013806 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276013807 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931276013808 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 931276013809 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 931276013810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276013811 active site 931276013812 motif I; other site 931276013813 motif II; other site 931276013814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276013815 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276013816 beta-galactosidase; Region: BGL; TIGR03356 931276013817 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276013818 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276013819 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276013820 putative active site [active] 931276013821 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 931276013822 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 931276013823 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 931276013824 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 931276013825 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276013826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276013827 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276013828 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 931276013829 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 931276013830 FMN binding site [chemical binding]; other site 931276013831 active site 931276013832 catalytic residues [active] 931276013833 substrate binding site [chemical binding]; other site 931276013834 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276013835 HAMP domain; Region: HAMP; pfam00672 931276013836 dimerization interface [polypeptide binding]; other site 931276013837 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276013838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276013839 dimer interface [polypeptide binding]; other site 931276013840 putative CheW interface [polypeptide binding]; other site 931276013841 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276013842 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 931276013843 Peptidase family U32; Region: Peptidase_U32; pfam01136 931276013844 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931276013845 Beta-lactamase; Region: Beta-lactamase; pfam00144 931276013846 QueT transporter; Region: QueT; pfam06177 931276013847 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 931276013848 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 931276013849 active site 931276013850 metal binding site [ion binding]; metal-binding site 931276013851 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 931276013852 YibE/F-like protein; Region: YibE_F; pfam07907 931276013853 Predicted peptidase [General function prediction only]; Region: COG4099 931276013854 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931276013855 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276013856 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276013857 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931276013858 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931276013859 Walker A/P-loop; other site 931276013860 ATP binding site [chemical binding]; other site 931276013861 Q-loop/lid; other site 931276013862 ABC transporter signature motif; other site 931276013863 Walker B; other site 931276013864 D-loop; other site 931276013865 H-loop/switch region; other site 931276013866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931276013867 ABC-ATPase subunit interface; other site 931276013868 dimer interface [polypeptide binding]; other site 931276013869 putative PBP binding regions; other site 931276013870 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 931276013871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931276013872 ABC-ATPase subunit interface; other site 931276013873 dimer interface [polypeptide binding]; other site 931276013874 putative PBP binding regions; other site 931276013875 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931276013876 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 931276013877 siderophore binding site; other site 931276013878 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 931276013879 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 931276013880 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276013881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276013882 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 931276013883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931276013884 ABC-ATPase subunit interface; other site 931276013885 dimer interface [polypeptide binding]; other site 931276013886 putative PBP binding regions; other site 931276013887 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931276013888 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931276013889 Walker A/P-loop; other site 931276013890 ATP binding site [chemical binding]; other site 931276013891 Q-loop/lid; other site 931276013892 ABC transporter signature motif; other site 931276013893 Walker B; other site 931276013894 D-loop; other site 931276013895 H-loop/switch region; other site 931276013896 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 931276013897 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 931276013898 intersubunit interface [polypeptide binding]; other site 931276013899 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276013900 Cupin domain; Region: Cupin_2; cl17218 931276013901 Cupin domain; Region: Cupin_2; pfam07883 931276013902 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276013903 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 931276013904 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276013905 nucleotide binding site [chemical binding]; other site 931276013906 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931276013907 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 931276013908 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931276013909 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931276013910 ligand binding site [chemical binding]; other site 931276013911 flexible hinge region; other site 931276013912 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 931276013913 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 931276013914 substrate binding site [chemical binding]; other site 931276013915 THF binding site; other site 931276013916 zinc-binding site [ion binding]; other site 931276013917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276013918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276013919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276013920 dimerization interface [polypeptide binding]; other site 931276013921 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 931276013922 CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP; Region: cas1_HMARI; TIGR03641 931276013923 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 931276013924 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 931276013925 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 931276013926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931276013927 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 931276013928 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 931276013929 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 931276013930 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 931276013931 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 931276013932 Predicted transcriptional regulator [Transcription]; Region: COG2378 931276013933 WYL domain; Region: WYL; pfam13280 931276013934 hypothetical protein; Provisional; Region: PRK10621 931276013935 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 931276013936 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 931276013937 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 931276013938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276013939 ATP binding site [chemical binding]; other site 931276013940 putative Mg++ binding site [ion binding]; other site 931276013941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276013942 nucleotide binding region [chemical binding]; other site 931276013943 ATP-binding site [chemical binding]; other site 931276013944 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 931276013945 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 931276013946 active site 931276013947 trimer interface [polypeptide binding]; other site 931276013948 allosteric site; other site 931276013949 active site lid [active] 931276013950 hexamer (dimer of trimers) interface [polypeptide binding]; other site 931276013951 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276013952 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276013953 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276013954 putative active site [active] 931276013955 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276013956 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276013957 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276013958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276013959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276013960 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 931276013961 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 931276013962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931276013963 active site 931276013964 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 931276013965 dimer interface [polypeptide binding]; other site 931276013966 N-terminal domain interface [polypeptide binding]; other site 931276013967 sulfate 1 binding site; other site 931276013968 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 931276013969 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 931276013970 ligand binding site; other site 931276013971 oligomer interface; other site 931276013972 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 931276013973 dimer interface [polypeptide binding]; other site 931276013974 N-terminal domain interface [polypeptide binding]; other site 931276013975 sulfate 1 binding site; other site 931276013976 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276013977 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276013978 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 931276013979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276013980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276013981 DNA binding site [nucleotide binding] 931276013982 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276013983 ligand binding site [chemical binding]; other site 931276013984 dimerization interface [polypeptide binding]; other site 931276013985 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 931276013986 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 931276013987 hexamer (dimer of trimers) interface [polypeptide binding]; other site 931276013988 substrate binding site [chemical binding]; other site 931276013989 trimer interface [polypeptide binding]; other site 931276013990 Mn binding site [ion binding]; other site 931276013991 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 931276013992 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 931276013993 N- and C-terminal domain interface [polypeptide binding]; other site 931276013994 active site 931276013995 MgATP binding site [chemical binding]; other site 931276013996 catalytic site [active] 931276013997 metal binding site [ion binding]; metal-binding site 931276013998 putative glycerol binding site [chemical binding]; other site 931276013999 putative homotetramer interface [polypeptide binding]; other site 931276014000 putative homodimer interface [polypeptide binding]; other site 931276014001 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 931276014002 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276014003 PYR/PP interface [polypeptide binding]; other site 931276014004 dimer interface [polypeptide binding]; other site 931276014005 TPP binding site [chemical binding]; other site 931276014006 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276014007 transketolase; Reviewed; Region: PRK05899 931276014008 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931276014009 TPP-binding site [chemical binding]; other site 931276014010 dimer interface [polypeptide binding]; other site 931276014011 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 931276014012 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 931276014013 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 931276014014 mannonate dehydratase; Provisional; Region: PRK03906 931276014015 mannonate dehydratase; Region: uxuA; TIGR00695 931276014016 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276014017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014018 dimer interface [polypeptide binding]; other site 931276014019 conserved gate region; other site 931276014020 putative PBP binding loops; other site 931276014021 ABC-ATPase subunit interface; other site 931276014022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014023 dimer interface [polypeptide binding]; other site 931276014024 conserved gate region; other site 931276014025 putative PBP binding loops; other site 931276014026 ABC-ATPase subunit interface; other site 931276014027 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276014028 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276014029 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276014030 HAMP domain; Region: HAMP; pfam00672 931276014031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276014032 dimer interface [polypeptide binding]; other site 931276014033 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276014034 putative CheW interface [polypeptide binding]; other site 931276014035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276014036 Response regulator receiver domain; Region: Response_reg; pfam00072 931276014037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014038 active site 931276014039 phosphorylation site [posttranslational modification] 931276014040 intermolecular recognition site; other site 931276014041 dimerization interface [polypeptide binding]; other site 931276014042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276014043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014044 Histidine kinase; Region: His_kinase; pfam06580 931276014045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014046 ATP binding site [chemical binding]; other site 931276014047 Mg2+ binding site [ion binding]; other site 931276014048 G-X-G motif; other site 931276014049 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276014050 active site turn [active] 931276014051 phosphorylation site [posttranslational modification] 931276014052 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 931276014053 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276014054 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 931276014055 Cupin domain; Region: Cupin_2; pfam07883 931276014056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276014057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014058 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 931276014059 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276014060 putative active site [active] 931276014061 putative metal binding site [ion binding]; other site 931276014062 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 931276014063 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 931276014064 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 931276014065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014066 active site 931276014067 phosphorylation site [posttranslational modification] 931276014068 intermolecular recognition site; other site 931276014069 dimerization interface [polypeptide binding]; other site 931276014070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014071 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931276014072 HAMP domain; Region: HAMP; pfam00672 931276014073 Histidine kinase; Region: His_kinase; pfam06580 931276014074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014075 ATP binding site [chemical binding]; other site 931276014076 Mg2+ binding site [ion binding]; other site 931276014077 G-X-G motif; other site 931276014078 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 931276014079 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 931276014080 active site 931276014081 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 931276014082 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 931276014083 inhibitor binding site; inhibition site 931276014084 active site 931276014085 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 931276014086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276014087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014088 dimer interface [polypeptide binding]; other site 931276014089 conserved gate region; other site 931276014090 ABC-ATPase subunit interface; other site 931276014091 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 931276014092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014093 dimer interface [polypeptide binding]; other site 931276014094 conserved gate region; other site 931276014095 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 931276014096 ABC-ATPase subunit interface; other site 931276014097 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276014098 Carboxylesterase family; Region: COesterase; pfam00135 931276014099 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 931276014100 substrate binding pocket [chemical binding]; other site 931276014101 catalytic triad [active] 931276014102 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 931276014103 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 931276014104 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 931276014105 active site 931276014106 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276014107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276014108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276014109 Walker A/P-loop; other site 931276014110 ATP binding site [chemical binding]; other site 931276014111 Q-loop/lid; other site 931276014112 ABC transporter signature motif; other site 931276014113 Walker B; other site 931276014114 D-loop; other site 931276014115 H-loop/switch region; other site 931276014116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276014117 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276014118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276014119 Walker A/P-loop; other site 931276014120 ATP binding site [chemical binding]; other site 931276014121 Q-loop/lid; other site 931276014122 ABC transporter signature motif; other site 931276014123 Walker B; other site 931276014124 D-loop; other site 931276014125 H-loop/switch region; other site 931276014126 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 931276014127 active site 931276014128 catalytic triad [active] 931276014129 oxyanion hole [active] 931276014130 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276014131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014132 dimer interface [polypeptide binding]; other site 931276014133 conserved gate region; other site 931276014134 putative PBP binding loops; other site 931276014135 ABC-ATPase subunit interface; other site 931276014136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014137 dimer interface [polypeptide binding]; other site 931276014138 conserved gate region; other site 931276014139 putative PBP binding loops; other site 931276014140 ABC-ATPase subunit interface; other site 931276014141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276014142 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276014143 Response regulator receiver domain; Region: Response_reg; pfam00072 931276014144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014145 active site 931276014146 phosphorylation site [posttranslational modification] 931276014147 intermolecular recognition site; other site 931276014148 dimerization interface [polypeptide binding]; other site 931276014149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276014151 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931276014152 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276014153 dimerization interface [polypeptide binding]; other site 931276014154 Histidine kinase; Region: His_kinase; pfam06580 931276014155 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 931276014156 ATP binding site [chemical binding]; other site 931276014157 Mg2+ binding site [ion binding]; other site 931276014158 G-X-G motif; other site 931276014159 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 931276014160 substrate binding site [chemical binding]; other site 931276014161 active site 931276014162 Probable beta-xylosidase; Provisional; Region: PLN03080 931276014163 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 931276014164 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 931276014165 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276014166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276014167 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 931276014168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276014169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276014170 DNA binding residues [nucleotide binding] 931276014171 Domain of unknown function (DUF956); Region: DUF956; pfam06115 931276014172 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 931276014173 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 931276014174 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 931276014175 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 931276014176 active pocket/dimerization site; other site 931276014177 active site 931276014178 phosphorylation site [posttranslational modification] 931276014179 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 931276014180 active site 931276014181 phosphorylation site [posttranslational modification] 931276014182 alpha-glucosidase; Provisional; Region: PRK10426 931276014183 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 931276014184 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 931276014185 putative active site [active] 931276014186 putative catalytic site [active] 931276014187 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 931276014188 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 931276014189 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 931276014190 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 931276014191 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 931276014192 putative active site [active] 931276014193 putative catalytic site [active] 931276014194 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276014195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014196 Glucuronate isomerase; Region: UxaC; pfam02614 931276014197 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 931276014198 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 931276014199 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 931276014200 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 931276014201 mannonate dehydratase; Provisional; Region: PRK03906 931276014202 mannonate dehydratase; Region: uxuA; TIGR00695 931276014203 Transcriptional regulators [Transcription]; Region: GntR; COG1802 931276014204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276014205 DNA-binding site [nucleotide binding]; DNA binding site 931276014206 FCD domain; Region: FCD; pfam07729 931276014207 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276014208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276014210 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 931276014211 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931276014212 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 931276014213 acyl-activating enzyme (AAE) consensus motif; other site 931276014214 acyl-activating enzyme (AAE) consensus motif; other site 931276014215 putative AMP binding site [chemical binding]; other site 931276014216 putative active site [active] 931276014217 putative CoA binding site [chemical binding]; other site 931276014218 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 931276014219 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 931276014220 active site 931276014221 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276014222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276014223 putative CheW interface [polypeptide binding]; other site 931276014224 M6 family metalloprotease domain; Region: M6dom_TIGR03296 931276014225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276014226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276014227 dimerization interface [polypeptide binding]; other site 931276014228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276014229 dimer interface [polypeptide binding]; other site 931276014230 phosphorylation site [posttranslational modification] 931276014231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014232 ATP binding site [chemical binding]; other site 931276014233 Mg2+ binding site [ion binding]; other site 931276014234 G-X-G motif; other site 931276014235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276014236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014237 active site 931276014238 phosphorylation site [posttranslational modification] 931276014239 intermolecular recognition site; other site 931276014240 dimerization interface [polypeptide binding]; other site 931276014241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276014242 DNA binding site [nucleotide binding] 931276014243 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 931276014244 thiamine phosphate binding site [chemical binding]; other site 931276014245 active site 931276014246 pyrophosphate binding site [ion binding]; other site 931276014247 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 931276014248 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 931276014249 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 931276014250 ThiS interaction site; other site 931276014251 putative active site [active] 931276014252 tetramer interface [polypeptide binding]; other site 931276014253 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 931276014254 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 931276014255 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 931276014256 putative ATP binding site [chemical binding]; other site 931276014257 putative substrate interface [chemical binding]; other site 931276014258 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 931276014259 thiS-thiF/thiG interaction site; other site 931276014260 putative proline-specific permease; Provisional; Region: proY; PRK10580 931276014261 RyR domain; Region: RyR; pfam02026 931276014262 Helix-turn-helix domain; Region: HTH_18; pfam12833 931276014263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014264 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 931276014265 homotrimer interaction site [polypeptide binding]; other site 931276014266 putative active site [active] 931276014267 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 931276014268 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931276014269 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931276014270 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 931276014271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931276014272 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931276014273 catalytic loop [active] 931276014274 iron binding site [ion binding]; other site 931276014275 ornithine cyclodeaminase; Validated; Region: PRK06199 931276014276 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 931276014277 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276014278 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276014279 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276014280 active site 931276014281 P-loop; other site 931276014282 phosphorylation site [posttranslational modification] 931276014283 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276014284 methionine cluster; other site 931276014285 active site 931276014286 phosphorylation site [posttranslational modification] 931276014287 metal binding site [ion binding]; metal-binding site 931276014288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276014289 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 931276014290 Walker A motif; other site 931276014291 ATP binding site [chemical binding]; other site 931276014292 Walker B motif; other site 931276014293 arginine finger; other site 931276014294 Transcriptional antiterminator [Transcription]; Region: COG3933 931276014295 PRD domain; Region: PRD; pfam00874 931276014296 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 931276014297 active pocket/dimerization site; other site 931276014298 active site 931276014299 phosphorylation site [posttranslational modification] 931276014300 PRD domain; Region: PRD; pfam00874 931276014301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276014302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276014303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276014305 putative substrate translocation pore; other site 931276014306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014307 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276014308 HAMP domain; Region: HAMP; pfam00672 931276014309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276014310 dimer interface [polypeptide binding]; other site 931276014311 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276014312 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276014313 dimer interface [polypeptide binding]; other site 931276014314 putative CheW interface [polypeptide binding]; other site 931276014315 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931276014316 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 931276014317 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 931276014318 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 931276014319 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 931276014320 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 931276014321 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 931276014322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276014323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276014324 dimer interface [polypeptide binding]; other site 931276014325 phosphorylation site [posttranslational modification] 931276014326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014327 ATP binding site [chemical binding]; other site 931276014328 Mg2+ binding site [ion binding]; other site 931276014329 G-X-G motif; other site 931276014330 Response regulator receiver domain; Region: Response_reg; pfam00072 931276014331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014332 active site 931276014333 phosphorylation site [posttranslational modification] 931276014334 intermolecular recognition site; other site 931276014335 dimerization interface [polypeptide binding]; other site 931276014336 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 931276014337 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931276014338 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931276014339 B12 binding site [chemical binding]; other site 931276014340 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 931276014341 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276014342 beta-galactosidase; Region: BGL; TIGR03356 931276014343 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 931276014344 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276014345 active site turn [active] 931276014346 phosphorylation site [posttranslational modification] 931276014347 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276014348 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 931276014349 HPr interaction site; other site 931276014350 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276014351 active site 931276014352 phosphorylation site [posttranslational modification] 931276014353 CAT RNA binding domain; Region: CAT_RBD; smart01061 931276014354 transcriptional antiterminator BglG; Provisional; Region: PRK09772 931276014355 PRD domain; Region: PRD; pfam00874 931276014356 PRD domain; Region: PRD; pfam00874 931276014357 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 931276014358 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 931276014359 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 931276014360 active site 931276014361 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 931276014362 RNAase interaction site [polypeptide binding]; other site 931276014363 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 931276014364 active site 931276014365 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276014366 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931276014367 putative DNA binding site [nucleotide binding]; other site 931276014368 dimerization interface [polypeptide binding]; other site 931276014369 putative Zn2+ binding site [ion binding]; other site 931276014370 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931276014371 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 931276014372 active site 931276014373 catalytic tetrad [active] 931276014374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276014376 putative substrate translocation pore; other site 931276014377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014378 putative substrate translocation pore; other site 931276014379 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 931276014380 nucleotide binding site/active site [active] 931276014381 HIT family signature motif; other site 931276014382 catalytic residue [active] 931276014383 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276014384 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931276014385 Glucuronate isomerase; Region: UxaC; pfam02614 931276014386 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 931276014387 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 931276014388 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 931276014389 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 931276014390 mannonate dehydratase; Provisional; Region: PRK03906 931276014391 mannonate dehydratase; Region: uxuA; TIGR00695 931276014392 Transcriptional regulators [Transcription]; Region: FadR; COG2186 931276014393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276014394 DNA-binding site [nucleotide binding]; DNA binding site 931276014395 FCD domain; Region: FCD; pfam07729 931276014396 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 931276014397 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931276014398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276014399 non-specific DNA binding site [nucleotide binding]; other site 931276014400 salt bridge; other site 931276014401 sequence-specific DNA binding site [nucleotide binding]; other site 931276014402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276014403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014404 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931276014405 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931276014406 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 931276014407 putative FMN binding site [chemical binding]; other site 931276014408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276014409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276014410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276014411 dimerization interface [polypeptide binding]; other site 931276014412 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 931276014413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276014414 NmrA-like family; Region: NmrA; pfam05368 931276014415 NAD(P) binding site [chemical binding]; other site 931276014416 active site 931276014417 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276014418 beta-galactosidase; Region: BGL; TIGR03356 931276014419 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 931276014420 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276014421 active site turn [active] 931276014422 phosphorylation site [posttranslational modification] 931276014423 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276014424 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931276014425 HPr interaction site; other site 931276014426 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276014427 active site 931276014428 phosphorylation site [posttranslational modification] 931276014429 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276014430 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276014431 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 931276014432 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 931276014433 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276014434 tetramer interface [polypeptide binding]; other site 931276014435 active site 931276014436 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 931276014437 active site 931276014438 dimer interface [polypeptide binding]; other site 931276014439 magnesium binding site [ion binding]; other site 931276014440 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 931276014441 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 931276014442 NAD binding site [chemical binding]; other site 931276014443 sugar binding site [chemical binding]; other site 931276014444 divalent metal binding site [ion binding]; other site 931276014445 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276014446 dimer interface [polypeptide binding]; other site 931276014447 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 931276014448 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276014449 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276014450 active site turn [active] 931276014451 phosphorylation site [posttranslational modification] 931276014452 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276014453 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276014454 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276014455 putative active site [active] 931276014456 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 931276014457 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 931276014458 NAD binding site [chemical binding]; other site 931276014459 catalytic residues [active] 931276014460 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931276014461 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276014462 DNA binding residues [nucleotide binding] 931276014463 putative dimer interface [polypeptide binding]; other site 931276014464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276014466 putative substrate translocation pore; other site 931276014467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276014468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276014469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931276014470 dimerization interface [polypeptide binding]; other site 931276014471 Predicted flavoprotein [General function prediction only]; Region: COG0431 931276014472 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276014473 FMN-binding domain; Region: FMN_bind; cl01081 931276014474 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 931276014475 L-aspartate oxidase; Provisional; Region: PRK06175 931276014476 Predicted flavoprotein [General function prediction only]; Region: COG0431 931276014477 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931276014478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276014479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276014480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276014481 dimerization interface [polypeptide binding]; other site 931276014482 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 931276014483 ApbE family; Region: ApbE; pfam02424 931276014484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276014485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931276014486 dimerization interface [polypeptide binding]; other site 931276014487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276014488 dimer interface [polypeptide binding]; other site 931276014489 phosphorylation site [posttranslational modification] 931276014490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014491 ATP binding site [chemical binding]; other site 931276014492 Mg2+ binding site [ion binding]; other site 931276014493 G-X-G motif; other site 931276014494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276014495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014496 active site 931276014497 phosphorylation site [posttranslational modification] 931276014498 intermolecular recognition site; other site 931276014499 dimerization interface [polypeptide binding]; other site 931276014500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276014501 DNA binding site [nucleotide binding] 931276014502 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 931276014503 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 931276014504 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931276014505 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 931276014506 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 931276014507 dimerization interface [polypeptide binding]; other site 931276014508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276014509 dimer interface [polypeptide binding]; other site 931276014510 phosphorylation site [posttranslational modification] 931276014511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014512 ATP binding site [chemical binding]; other site 931276014513 Mg2+ binding site [ion binding]; other site 931276014514 G-X-G motif; other site 931276014515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276014516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014517 active site 931276014518 phosphorylation site [posttranslational modification] 931276014519 intermolecular recognition site; other site 931276014520 dimerization interface [polypeptide binding]; other site 931276014521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276014522 DNA binding site [nucleotide binding] 931276014523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276014524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276014525 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276014526 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 931276014527 Protein of unknown function, DUF606; Region: DUF606; pfam04657 931276014528 RibD C-terminal domain; Region: RibD_C; cl17279 931276014529 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 931276014530 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 931276014531 Ca binding site [ion binding]; other site 931276014532 active site 931276014533 catalytic site [active] 931276014534 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276014535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014536 dimer interface [polypeptide binding]; other site 931276014537 conserved gate region; other site 931276014538 putative PBP binding loops; other site 931276014539 ABC-ATPase subunit interface; other site 931276014540 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 931276014541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014542 dimer interface [polypeptide binding]; other site 931276014543 conserved gate region; other site 931276014544 putative PBP binding loops; other site 931276014545 ABC-ATPase subunit interface; other site 931276014546 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276014547 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276014548 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276014549 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276014550 DNA binding site [nucleotide binding] 931276014551 domain linker motif; other site 931276014552 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276014553 dimerization interface [polypeptide binding]; other site 931276014554 ligand binding site [chemical binding]; other site 931276014555 short chain dehydrogenase; Provisional; Region: PRK06523 931276014556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276014557 NAD(P) binding site [chemical binding]; other site 931276014558 active site 931276014559 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 931276014560 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931276014561 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276014562 DNA binding residues [nucleotide binding] 931276014563 putative dimer interface [polypeptide binding]; other site 931276014564 short chain dehydrogenase; Provisional; Region: PRK06197 931276014565 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 931276014566 putative NAD(P) binding site [chemical binding]; other site 931276014567 active site 931276014568 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 931276014569 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 931276014570 putative ligand binding site [chemical binding]; other site 931276014571 putative NAD binding site [chemical binding]; other site 931276014572 catalytic site [active] 931276014573 hypothetical protein; Validated; Region: PRK06201 931276014574 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 931276014575 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 931276014576 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 931276014577 ligand binding site [chemical binding]; other site 931276014578 NAD binding site [chemical binding]; other site 931276014579 dimerization interface [polypeptide binding]; other site 931276014580 catalytic site [active] 931276014581 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 931276014582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931276014583 active site 931276014584 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 931276014585 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 931276014586 transmembrane helices; other site 931276014587 Propionate catabolism activator; Region: PrpR_N; pfam06506 931276014588 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 931276014589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276014590 Walker A motif; other site 931276014591 ATP binding site [chemical binding]; other site 931276014592 Walker B motif; other site 931276014593 arginine finger; other site 931276014594 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931276014595 AAA domain; Region: AAA_33; pfam13671 931276014596 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 931276014597 active site 931276014598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276014599 D-galactonate transporter; Region: 2A0114; TIGR00893 931276014600 putative substrate translocation pore; other site 931276014601 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 931276014602 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 931276014603 active site 931276014604 intersubunit interface [polypeptide binding]; other site 931276014605 catalytic residue [active] 931276014606 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 931276014607 Transcriptional regulator [Transcription]; Region: IclR; COG1414 931276014608 Bacterial transcriptional regulator; Region: IclR; pfam01614 931276014609 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 931276014610 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 931276014611 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931276014612 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931276014613 Walker A/P-loop; other site 931276014614 ATP binding site [chemical binding]; other site 931276014615 Q-loop/lid; other site 931276014616 ABC transporter signature motif; other site 931276014617 Walker B; other site 931276014618 D-loop; other site 931276014619 H-loop/switch region; other site 931276014620 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931276014621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276014622 non-specific DNA binding site [nucleotide binding]; other site 931276014623 salt bridge; other site 931276014624 sequence-specific DNA binding site [nucleotide binding]; other site 931276014625 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276014626 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276014627 Cupin domain; Region: Cupin_2; cl17218 931276014628 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 931276014629 Dehydroquinase class II; Region: DHquinase_II; pfam01220 931276014630 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 931276014631 trimer interface [polypeptide binding]; other site 931276014632 active site 931276014633 dimer interface [polypeptide binding]; other site 931276014634 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931276014635 active site 931276014636 metal binding site [ion binding]; metal-binding site 931276014637 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 931276014638 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 931276014639 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 931276014640 Cupin domain; Region: Cupin_2; pfam07883 931276014641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276014642 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931276014643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276014645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276014646 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 931276014647 Coenzyme A transferase; Region: CoA_trans; smart00882 931276014648 Coenzyme A transferase; Region: CoA_trans; cl17247 931276014649 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 931276014650 dimer interaction site [polypeptide binding]; other site 931276014651 substrate-binding tunnel; other site 931276014652 active site 931276014653 catalytic site [active] 931276014654 substrate binding site [chemical binding]; other site 931276014655 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 931276014656 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 931276014657 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 931276014658 metal binding triad [ion binding]; metal-binding site 931276014659 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 931276014660 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931276014661 active site 931276014662 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931276014663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276014664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276014665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276014666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931276014667 dimerization interface [polypeptide binding]; other site 931276014668 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 931276014669 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931276014670 acyl-activating enzyme (AAE) consensus motif; other site 931276014671 AMP binding site [chemical binding]; other site 931276014672 active site 931276014673 CoA binding site [chemical binding]; other site 931276014674 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 931276014675 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 931276014676 dimer interface [polypeptide binding]; other site 931276014677 active site 931276014678 BioY family; Region: BioY; pfam02632 931276014679 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 931276014680 active site 2 [active] 931276014681 active site 1 [active] 931276014682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931276014683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276014684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276014685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276014686 dimerization interface [polypeptide binding]; other site 931276014687 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 931276014688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276014689 active site 931276014690 phosphorylation site [posttranslational modification] 931276014691 intermolecular recognition site; other site 931276014692 dimerization interface [polypeptide binding]; other site 931276014693 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 931276014694 PAS domain; Region: PAS; smart00091 931276014695 putative active site [active] 931276014696 heme pocket [chemical binding]; other site 931276014697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014698 ATP binding site [chemical binding]; other site 931276014699 Mg2+ binding site [ion binding]; other site 931276014700 G-X-G motif; other site 931276014701 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 931276014702 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 931276014703 Malic enzyme, N-terminal domain; Region: malic; pfam00390 931276014704 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 931276014705 putative NAD(P) binding site [chemical binding]; other site 931276014706 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931276014707 active site 931276014708 catalytic residues [active] 931276014709 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 931276014710 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 931276014711 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 931276014712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276014713 FeS/SAM binding site; other site 931276014714 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 931276014715 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276014716 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276014717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276014718 Walker A/P-loop; other site 931276014719 ATP binding site [chemical binding]; other site 931276014720 Q-loop/lid; other site 931276014721 ABC transporter signature motif; other site 931276014722 Walker B; other site 931276014723 D-loop; other site 931276014724 H-loop/switch region; other site 931276014725 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931276014726 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 931276014727 inhibitor-cofactor binding pocket; inhibition site 931276014728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276014729 catalytic residue [active] 931276014730 AAA domain; Region: AAA_26; pfam13500 931276014731 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 931276014732 biotin synthase; Region: bioB; TIGR00433 931276014733 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276014734 FeS/SAM binding site; other site 931276014735 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 931276014736 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 931276014737 Protein of unknown function DUF262; Region: DUF262; pfam03235 931276014738 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 931276014739 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931276014740 HPr interaction site; other site 931276014741 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276014742 active site 931276014743 phosphorylation site [posttranslational modification] 931276014744 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 931276014745 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 931276014746 NAD binding site [chemical binding]; other site 931276014747 sugar binding site [chemical binding]; other site 931276014748 divalent metal binding site [ion binding]; other site 931276014749 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276014750 dimer interface [polypeptide binding]; other site 931276014751 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276014752 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 931276014753 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276014754 active site turn [active] 931276014755 phosphorylation site [posttranslational modification] 931276014756 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276014757 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276014758 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276014759 putative active site [active] 931276014760 PAS fold; Region: PAS_4; pfam08448 931276014761 PAS domain S-box; Region: sensory_box; TIGR00229 931276014762 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 931276014763 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 931276014764 anti sigma factor interaction site; other site 931276014765 regulatory phosphorylation site [posttranslational modification]; other site 931276014766 Cache domain; Region: Cache_1; pfam02743 931276014767 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276014768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276014769 dimerization interface [polypeptide binding]; other site 931276014770 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276014771 dimer interface [polypeptide binding]; other site 931276014772 putative CheW interface [polypeptide binding]; other site 931276014773 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 931276014774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014775 ATP binding site [chemical binding]; other site 931276014776 Mg2+ binding site [ion binding]; other site 931276014777 G-X-G motif; other site 931276014778 Predicted membrane protein [Function unknown]; Region: COG2364 931276014779 putative oxidoreductase; Provisional; Region: PRK12831 931276014780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276014781 Propionate catabolism activator; Region: PrpR_N; pfam06506 931276014782 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 931276014783 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 931276014784 FAD binding pocket [chemical binding]; other site 931276014785 FAD binding motif [chemical binding]; other site 931276014786 phosphate binding motif [ion binding]; other site 931276014787 beta-alpha-beta structure motif; other site 931276014788 NAD binding pocket [chemical binding]; other site 931276014789 Iron coordination center [ion binding]; other site 931276014790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276014791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276014792 ATP binding site [chemical binding]; other site 931276014793 Mg2+ binding site [ion binding]; other site 931276014794 G-X-G motif; other site 931276014795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931276014796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276014797 S-adenosylmethionine binding site [chemical binding]; other site 931276014798 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 931276014799 trimer interface [polypeptide binding]; other site 931276014800 active site 931276014801 Cna protein B-type domain; Region: Cna_B; pfam05738 931276014802 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276014803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276014804 metal binding site [ion binding]; metal-binding site 931276014805 active site 931276014806 I-site; other site 931276014807 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276014808 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 931276014809 NodB motif; other site 931276014810 active site 931276014811 catalytic site [active] 931276014812 Zn binding site [ion binding]; other site 931276014813 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276014814 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276014815 metal binding site [ion binding]; metal-binding site 931276014816 active site 931276014817 I-site; other site 931276014818 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931276014819 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 931276014820 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 931276014821 Ligand Binding Site [chemical binding]; other site 931276014822 Predicted membrane protein [Function unknown]; Region: COG4684 931276014823 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 931276014824 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 931276014825 putative active site pocket [active] 931276014826 cleavage site 931276014827 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 931276014828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276014829 Walker A/P-loop; other site 931276014830 ATP binding site [chemical binding]; other site 931276014831 Q-loop/lid; other site 931276014832 ABC transporter signature motif; other site 931276014833 Walker B; other site 931276014834 D-loop; other site 931276014835 H-loop/switch region; other site 931276014836 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931276014837 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931276014838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276014839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276014840 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276014841 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 931276014842 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276014843 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 931276014844 Clp amino terminal domain; Region: Clp_N; pfam02861 931276014845 Clp amino terminal domain; Region: Clp_N; pfam02861 931276014846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276014847 Walker A motif; other site 931276014848 ATP binding site [chemical binding]; other site 931276014849 Walker B motif; other site 931276014850 arginine finger; other site 931276014851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276014852 Walker A motif; other site 931276014853 ATP binding site [chemical binding]; other site 931276014854 Walker B motif; other site 931276014855 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 931276014856 FOG: CBS domain [General function prediction only]; Region: COG0517 931276014857 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 931276014858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276014859 non-specific DNA binding site [nucleotide binding]; other site 931276014860 salt bridge; other site 931276014861 sequence-specific DNA binding site [nucleotide binding]; other site 931276014862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276014863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276014864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276014865 non-specific DNA binding site [nucleotide binding]; other site 931276014866 salt bridge; other site 931276014867 sequence-specific DNA binding site [nucleotide binding]; other site 931276014868 Tetratricopeptide repeat; Region: TPR_12; pfam13424 931276014869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931276014870 binding surface 931276014871 TPR motif; other site 931276014872 YtxH-like protein; Region: YtxH; cl02079 931276014873 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 931276014874 RNA/DNA hybrid binding site [nucleotide binding]; other site 931276014875 active site 931276014876 Uncharacterized conserved protein [Function unknown]; Region: COG3339 931276014877 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 931276014878 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 931276014879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276014880 dimer interface [polypeptide binding]; other site 931276014881 conserved gate region; other site 931276014882 ABC-ATPase subunit interface; other site 931276014883 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 931276014884 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 931276014885 Walker A/P-loop; other site 931276014886 ATP binding site [chemical binding]; other site 931276014887 Q-loop/lid; other site 931276014888 ABC transporter signature motif; other site 931276014889 Walker B; other site 931276014890 D-loop; other site 931276014891 H-loop/switch region; other site 931276014892 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 931276014893 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 931276014894 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 931276014895 active site 931276014896 metal binding site [ion binding]; metal-binding site 931276014897 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 931276014898 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 931276014899 SmpB-tmRNA interface; other site 931276014900 ribonuclease R; Region: RNase_R; TIGR02063 931276014901 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 931276014902 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 931276014903 RNB domain; Region: RNB; pfam00773 931276014904 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 931276014905 RNA binding site [nucleotide binding]; other site 931276014906 RNA polymerase factor sigma-70; Validated; Region: PRK06811 931276014907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276014908 Preprotein translocase SecG subunit; Region: SecG; pfam03840 931276014909 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 931276014910 enolase; Provisional; Region: eno; PRK00077 931276014911 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 931276014912 dimer interface [polypeptide binding]; other site 931276014913 metal binding site [ion binding]; metal-binding site 931276014914 substrate binding pocket [chemical binding]; other site 931276014915 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 931276014916 active site 931276014917 ATP binding site [chemical binding]; other site 931276014918 substrate binding site [chemical binding]; other site 931276014919 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931276014920 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931276014921 putative active site [active] 931276014922 putative NTP binding site [chemical binding]; other site 931276014923 putative nucleic acid binding site [nucleotide binding]; other site 931276014924 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931276014925 phosphoglyceromutase; Provisional; Region: PRK05434 931276014926 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 931276014927 triosephosphate isomerase; Provisional; Region: PRK14567 931276014928 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 931276014929 substrate binding site [chemical binding]; other site 931276014930 dimer interface [polypeptide binding]; other site 931276014931 catalytic triad [active] 931276014932 Phosphoglycerate kinase; Region: PGK; pfam00162 931276014933 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 931276014934 substrate binding site [chemical binding]; other site 931276014935 hinge regions; other site 931276014936 ADP binding site [chemical binding]; other site 931276014937 catalytic site [active] 931276014938 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 931276014939 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 931276014940 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 931276014941 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 931276014942 Predicted transcriptional regulator [Transcription]; Region: COG3388 931276014943 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 931276014944 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 931276014945 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 931276014946 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 931276014947 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 931276014948 EDD domain protein, DegV family; Region: DegV; TIGR00762 931276014949 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931276014950 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 931276014951 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 931276014952 VanW like protein; Region: VanW; pfam04294 931276014953 G5 domain; Region: G5; pfam07501 931276014954 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 931276014955 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931276014956 active site 931276014957 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 931276014958 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 931276014959 active site 931276014960 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276014961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276014962 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276014963 ABC transporter; Region: ABC_tran_2; pfam12848 931276014964 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276014965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276014966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276014967 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 931276014968 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931276014969 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276014970 catalytic residue [active] 931276014971 6-phosphofructokinase; Provisional; Region: PRK14072 931276014972 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 931276014973 active site 931276014974 ADP/pyrophosphate binding site [chemical binding]; other site 931276014975 dimerization interface [polypeptide binding]; other site 931276014976 allosteric effector site; other site 931276014977 fructose-1,6-bisphosphate binding site; other site 931276014978 Predicted membrane protein [Function unknown]; Region: COG1971 931276014979 Domain of unknown function DUF; Region: DUF204; pfam02659 931276014980 ferric uptake regulator; Provisional; Region: fur; PRK09462 931276014981 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 931276014982 metal binding site 2 [ion binding]; metal-binding site 931276014983 putative DNA binding helix; other site 931276014984 metal binding site 1 [ion binding]; metal-binding site 931276014985 dimer interface [polypeptide binding]; other site 931276014986 structural Zn2+ binding site [ion binding]; other site 931276014987 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 931276014988 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 931276014989 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931276014990 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 931276014991 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 931276014992 minor groove reading motif; other site 931276014993 helix-hairpin-helix signature motif; other site 931276014994 substrate binding pocket [chemical binding]; other site 931276014995 active site 931276014996 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 931276014997 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 931276014998 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 931276014999 putative acyl-acceptor binding pocket; other site 931276015000 serine O-acetyltransferase; Region: cysE; TIGR01172 931276015001 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 931276015002 trimer interface [polypeptide binding]; other site 931276015003 active site 931276015004 substrate binding site [chemical binding]; other site 931276015005 CoA binding site [chemical binding]; other site 931276015006 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931276015007 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931276015008 dimer interface [polypeptide binding]; other site 931276015009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276015010 catalytic residue [active] 931276015011 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 931276015012 hypothetical protein; Provisional; Region: PRK00955 931276015013 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 931276015014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276015015 Coenzyme A binding pocket [chemical binding]; other site 931276015016 putative lipid kinase; Reviewed; Region: PRK13059 931276015017 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 931276015018 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 931276015019 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 931276015020 SpoVR like protein; Region: SpoVR; pfam04293 931276015021 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 931276015022 hypothetical protein; Provisional; Region: PRK05325 931276015023 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 931276015024 AAA ATPase domain; Region: AAA_16; pfam13191 931276015025 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 931276015026 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 931276015027 EAL domain; Region: EAL; pfam00563 931276015028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 931276015029 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 931276015030 Probable transposase; Region: OrfB_IS605; pfam01385 931276015031 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 931276015032 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931276015033 MerR family regulatory protein; Region: MerR; pfam00376 931276015034 DNA binding residues [nucleotide binding] 931276015035 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 931276015036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276015037 motif II; other site 931276015038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276015039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276015040 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 931276015041 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276015042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276015043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276015044 Walker A/P-loop; other site 931276015045 ATP binding site [chemical binding]; other site 931276015046 Q-loop/lid; other site 931276015047 ABC transporter signature motif; other site 931276015048 Walker B; other site 931276015049 D-loop; other site 931276015050 H-loop/switch region; other site 931276015051 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276015052 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276015053 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931276015054 Walker A/P-loop; other site 931276015055 ATP binding site [chemical binding]; other site 931276015056 Q-loop/lid; other site 931276015057 ABC transporter signature motif; other site 931276015058 Walker B; other site 931276015059 D-loop; other site 931276015060 H-loop/switch region; other site 931276015061 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 931276015062 E3 interaction surface; other site 931276015063 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276015064 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276015065 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276015066 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276015067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276015068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276015069 putative substrate translocation pore; other site 931276015070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276015071 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276015072 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 931276015073 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276015074 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 931276015075 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 931276015076 HlyD family secretion protein; Region: HlyD_3; pfam13437 931276015077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276015078 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 931276015079 active site 931276015080 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276015081 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276015082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276015083 dimer interface [polypeptide binding]; other site 931276015084 putative CheW interface [polypeptide binding]; other site 931276015085 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 931276015086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276015087 HD domain; Region: HD_4; pfam13328 931276015088 Predicted acetyltransferase [General function prediction only]; Region: COG2388 931276015089 YmaF family; Region: YmaF; pfam12788 931276015090 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 931276015091 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 931276015092 Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160 931276015093 putative homodimer interface [polypeptide binding]; other site 931276015094 putative homotetramer interface [polypeptide binding]; other site 931276015095 putative metal binding site [ion binding]; other site 931276015096 putative homodimer-homodimer interface [polypeptide binding]; other site 931276015097 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 931276015098 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276015099 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931276015100 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 931276015101 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 931276015102 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 931276015103 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 931276015104 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 931276015105 homodimer interface [polypeptide binding]; other site 931276015106 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 931276015107 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 931276015108 active site 931276015109 homodimer interface [polypeptide binding]; other site 931276015110 catalytic site [active] 931276015111 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276015112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015113 dimer interface [polypeptide binding]; other site 931276015114 conserved gate region; other site 931276015115 ABC-ATPase subunit interface; other site 931276015116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015117 dimer interface [polypeptide binding]; other site 931276015118 conserved gate region; other site 931276015119 putative PBP binding loops; other site 931276015120 ABC-ATPase subunit interface; other site 931276015121 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 931276015122 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 931276015123 active site 931276015124 homodimer interface [polypeptide binding]; other site 931276015125 catalytic site [active] 931276015126 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 931276015127 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 931276015128 active site 931276015129 catalytic site [active] 931276015130 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 931276015131 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 931276015132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276015133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276015134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276015135 DNA binding site [nucleotide binding] 931276015136 domain linker motif; other site 931276015137 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276015138 dimerization interface [polypeptide binding]; other site 931276015139 ligand binding site [chemical binding]; other site 931276015140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276015141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276015142 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 931276015143 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 931276015144 putative NAD(P) binding site [chemical binding]; other site 931276015145 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 931276015146 Recombinase; Region: Recombinase; pfam07508 931276015147 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 931276015148 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 931276015149 catalytic residues [active] 931276015150 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 931276015151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276015152 S-adenosylmethionine binding site [chemical binding]; other site 931276015153 RDD family; Region: RDD; cl00746 931276015154 SLBB domain; Region: SLBB; pfam10531 931276015155 comEA protein; Region: comE; TIGR01259 931276015156 Helix-hairpin-helix motif; Region: HHH; pfam00633 931276015157 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 931276015158 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 931276015159 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 931276015160 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 931276015161 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 931276015162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276015163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276015164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931276015165 dimerization interface [polypeptide binding]; other site 931276015166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276015167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276015168 dimer interface [polypeptide binding]; other site 931276015169 phosphorylation site [posttranslational modification] 931276015170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276015171 ATP binding site [chemical binding]; other site 931276015172 Mg2+ binding site [ion binding]; other site 931276015173 G-X-G motif; other site 931276015174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276015175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276015176 active site 931276015177 phosphorylation site [posttranslational modification] 931276015178 intermolecular recognition site; other site 931276015179 dimerization interface [polypeptide binding]; other site 931276015180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276015181 DNA binding site [nucleotide binding] 931276015182 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 931276015183 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 931276015184 active site 931276015185 Transcriptional regulator [Transcription]; Region: LytR; COG1316 931276015186 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 931276015187 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276015188 Zn2+ binding site [ion binding]; other site 931276015189 Mg2+ binding site [ion binding]; other site 931276015190 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 931276015191 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 931276015192 active site 931276015193 (T/H)XGH motif; other site 931276015194 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 931276015195 GTPase CgtA; Reviewed; Region: obgE; PRK12297 931276015196 GTP1/OBG; Region: GTP1_OBG; pfam01018 931276015197 Obg GTPase; Region: Obg; cd01898 931276015198 G1 box; other site 931276015199 GTP/Mg2+ binding site [chemical binding]; other site 931276015200 Switch I region; other site 931276015201 G2 box; other site 931276015202 G3 box; other site 931276015203 Switch II region; other site 931276015204 G4 box; other site 931276015205 G5 box; other site 931276015206 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 931276015207 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 931276015208 hypothetical protein; Provisional; Region: PRK14553 931276015209 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 931276015210 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 931276015211 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 931276015212 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 931276015213 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 931276015214 homodimer interface [polypeptide binding]; other site 931276015215 oligonucleotide binding site [chemical binding]; other site 931276015216 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 931276015217 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 931276015218 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 931276015219 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931276015220 B12 binding site [chemical binding]; other site 931276015221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931276015222 FeS/SAM binding site; other site 931276015223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 931276015224 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276015225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276015226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931276015227 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 931276015228 metal binding triad [ion binding]; metal-binding site 931276015229 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 931276015230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931276015231 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931276015232 catalytic residues [active] 931276015233 sugar efflux transporter; Region: 2A0120; TIGR00899 931276015234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276015235 putative substrate translocation pore; other site 931276015236 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 931276015237 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 931276015238 active site 931276015239 Zn binding site [ion binding]; other site 931276015240 putative alpha-glucosidase; Provisional; Region: PRK10658 931276015241 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 931276015242 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 931276015243 active site 931276015244 homotrimer interface [polypeptide binding]; other site 931276015245 catalytic site [active] 931276015246 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 931276015247 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 931276015248 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276015249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015250 dimer interface [polypeptide binding]; other site 931276015251 conserved gate region; other site 931276015252 putative PBP binding loops; other site 931276015253 ABC-ATPase subunit interface; other site 931276015254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 931276015255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015256 dimer interface [polypeptide binding]; other site 931276015257 conserved gate region; other site 931276015258 putative PBP binding loops; other site 931276015259 ABC-ATPase subunit interface; other site 931276015260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276015261 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276015262 Histidine kinase; Region: His_kinase; pfam06580 931276015263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276015264 ATP binding site [chemical binding]; other site 931276015265 Mg2+ binding site [ion binding]; other site 931276015266 G-X-G motif; other site 931276015267 Response regulator receiver domain; Region: Response_reg; pfam00072 931276015268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276015269 active site 931276015270 phosphorylation site [posttranslational modification] 931276015271 intermolecular recognition site; other site 931276015272 dimerization interface [polypeptide binding]; other site 931276015273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276015274 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276015275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276015276 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 931276015277 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 931276015278 homodimer interface [polypeptide binding]; other site 931276015279 substrate-cofactor binding pocket; other site 931276015280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276015281 catalytic residue [active] 931276015282 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 931276015283 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 931276015284 active site 931276015285 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 931276015286 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 931276015287 Peptidase family M50; Region: Peptidase_M50; pfam02163 931276015288 active site 931276015289 putative substrate binding region [chemical binding]; other site 931276015290 CBS domain; Region: CBS; pfam00571 931276015291 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 931276015292 Septum formation topological specificity factor MinE; Region: MinE; cl00538 931276015293 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 931276015294 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 931276015295 Switch I; other site 931276015296 Switch II; other site 931276015297 septum formation inhibitor; Reviewed; Region: minC; PRK00513 931276015298 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 931276015299 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 931276015300 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931276015301 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931276015302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 931276015303 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 931276015304 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 931276015305 rod shape-determining protein MreC; Provisional; Region: PRK13922 931276015306 rod shape-determining protein MreC; Region: MreC; pfam04085 931276015307 rod shape-determining protein MreB; Provisional; Region: PRK13927 931276015308 MreB and similar proteins; Region: MreB_like; cd10225 931276015309 nucleotide binding site [chemical binding]; other site 931276015310 Mg binding site [ion binding]; other site 931276015311 putative protofilament interaction site [polypeptide binding]; other site 931276015312 RodZ interaction site [polypeptide binding]; other site 931276015313 hypothetical protein; Reviewed; Region: PRK00024 931276015314 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 931276015315 MPN+ (JAMM) motif; other site 931276015316 Zinc-binding site [ion binding]; other site 931276015317 Maf-like protein; Reviewed; Region: PRK00078 931276015318 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 931276015319 active site 931276015320 dimer interface [polypeptide binding]; other site 931276015321 Sporulation related domain; Region: SPOR; cl10051 931276015322 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 931276015323 NlpC/P60 family; Region: NLPC_P60; pfam00877 931276015324 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 931276015325 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 931276015326 metal binding site [ion binding]; metal-binding site 931276015327 dimer interface [polypeptide binding]; other site 931276015328 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 931276015329 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 931276015330 domain interfaces; other site 931276015331 active site 931276015332 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 931276015333 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 931276015334 RNA binding site [nucleotide binding]; other site 931276015335 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 931276015336 RNA binding site [nucleotide binding]; other site 931276015337 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 931276015338 RNA binding site [nucleotide binding]; other site 931276015339 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 931276015340 RNA binding site [nucleotide binding]; other site 931276015341 domain interface; other site 931276015342 phage shock protein A; Region: phageshock_pspA; TIGR02977 931276015343 FOG: CBS domain [General function prediction only]; Region: COG0517 931276015344 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 931276015345 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 931276015346 active site 931276015347 catalytic site [active] 931276015348 substrate binding site [chemical binding]; other site 931276015349 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 931276015350 Walker A/P-loop; other site 931276015351 ATP binding site [chemical binding]; other site 931276015352 Q-loop/lid; other site 931276015353 ABC transporter signature motif; other site 931276015354 Walker B; other site 931276015355 D-loop; other site 931276015356 H-loop/switch region; other site 931276015357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276015358 Coenzyme A binding pocket [chemical binding]; other site 931276015359 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 931276015360 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 931276015361 metal binding site [ion binding]; metal-binding site 931276015362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276015363 Walker A/P-loop; other site 931276015364 ATP binding site [chemical binding]; other site 931276015365 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 931276015366 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 931276015367 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 931276015368 active site 931276015369 metal binding site [ion binding]; metal-binding site 931276015370 DNA binding site [nucleotide binding] 931276015371 TraC-like protein; Region: TraC; cl06725 931276015372 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 931276015373 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 931276015374 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 931276015375 Catalytic site [active] 931276015376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276015377 non-specific DNA binding site [nucleotide binding]; other site 931276015378 salt bridge; other site 931276015379 sequence-specific DNA binding site [nucleotide binding]; other site 931276015380 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931276015381 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 931276015382 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 931276015383 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 931276015384 putative active site [active] 931276015385 putative metal binding residues [ion binding]; other site 931276015386 putative triphosphate binding site [ion binding]; other site 931276015387 signature motif; other site 931276015388 dimer interface [polypeptide binding]; other site 931276015389 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931276015390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276015391 DNA-binding site [nucleotide binding]; DNA binding site 931276015392 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 931276015393 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 931276015394 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 931276015395 active site 931276015396 dimer interface [polypeptide binding]; other site 931276015397 Transposase, Mutator family; Region: Transposase_mut; pfam00872 931276015398 MULE transposase domain; Region: MULE; pfam10551 931276015399 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276015400 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276015401 nucleotide binding site [chemical binding]; other site 931276015402 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276015403 beta-galactosidase; Region: BGL; TIGR03356 931276015404 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276015405 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276015406 nucleotide binding site [chemical binding]; other site 931276015407 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 931276015408 Melibiase; Region: Melibiase; pfam02065 931276015409 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 931276015410 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 931276015411 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 931276015412 active site 931276015413 catalytic triad [active] 931276015414 oxyanion hole [active] 931276015415 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276015416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276015417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276015418 Walker A/P-loop; other site 931276015419 ATP binding site [chemical binding]; other site 931276015420 Q-loop/lid; other site 931276015421 ABC transporter signature motif; other site 931276015422 Walker B; other site 931276015423 D-loop; other site 931276015424 H-loop/switch region; other site 931276015425 Cupin domain; Region: Cupin_2; pfam07883 931276015426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276015427 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276015428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276015429 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 931276015430 active site 931276015431 catalytic triad [active] 931276015432 oxyanion hole [active] 931276015433 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276015434 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276015435 DNA binding site [nucleotide binding] 931276015436 domain linker motif; other site 931276015437 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 931276015438 Domain of unknown function (DUF377); Region: DUF377; pfam04041 931276015439 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 931276015440 active site 931276015441 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276015442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015443 dimer interface [polypeptide binding]; other site 931276015444 conserved gate region; other site 931276015445 putative PBP binding loops; other site 931276015446 ABC-ATPase subunit interface; other site 931276015447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015448 dimer interface [polypeptide binding]; other site 931276015449 conserved gate region; other site 931276015450 putative PBP binding loops; other site 931276015451 ABC-ATPase subunit interface; other site 931276015452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276015453 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931276015454 Protein of unknown function, DUF624; Region: DUF624; pfam04854 931276015455 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 931276015456 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 931276015457 Walker A/P-loop; other site 931276015458 ATP binding site [chemical binding]; other site 931276015459 Q-loop/lid; other site 931276015460 ABC transporter signature motif; other site 931276015461 Walker B; other site 931276015462 D-loop; other site 931276015463 H-loop/switch region; other site 931276015464 TOBE domain; Region: TOBE_2; pfam08402 931276015465 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 931276015466 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 931276015467 Interdomain contacts; other site 931276015468 Cytokine receptor motif; other site 931276015469 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 931276015470 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931276015471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276015472 Coenzyme A binding pocket [chemical binding]; other site 931276015473 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 931276015474 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276015475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276015476 dimer interface [polypeptide binding]; other site 931276015477 putative CheW interface [polypeptide binding]; other site 931276015478 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 931276015479 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 931276015480 active site 931276015481 catalytic residue [active] 931276015482 dimer interface [polypeptide binding]; other site 931276015483 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 931276015484 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 931276015485 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 931276015486 shikimate binding site; other site 931276015487 NAD(P) binding site [chemical binding]; other site 931276015488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276015489 D-galactonate transporter; Region: 2A0114; TIGR00893 931276015490 putative substrate translocation pore; other site 931276015491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276015492 putative substrate translocation pore; other site 931276015493 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276015494 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 931276015495 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 931276015496 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 931276015497 shikimate binding site; other site 931276015498 NAD(P) binding site [chemical binding]; other site 931276015499 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931276015500 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276015501 active site 931276015502 FMN binding site [chemical binding]; other site 931276015503 substrate binding site [chemical binding]; other site 931276015504 putative catalytic residue [active] 931276015505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931276015506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276015507 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 931276015508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276015509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276015510 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 931276015511 putative dimerization interface [polypeptide binding]; other site 931276015512 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931276015513 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931276015514 active site 931276015515 FMN binding site [chemical binding]; other site 931276015516 substrate binding site [chemical binding]; other site 931276015517 putative catalytic residue [active] 931276015518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931276015519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931276015520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931276015521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931276015522 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 931276015523 putative dimerization interface [polypeptide binding]; other site 931276015524 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 931276015525 Flavoprotein; Region: Flavoprotein; pfam02441 931276015526 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 931276015527 Uncharacterized conserved protein [Function unknown]; Region: COG1359 931276015528 prephenate dehydrogenase; Validated; Region: PRK08507 931276015529 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 931276015530 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 931276015531 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 931276015532 shikimate kinase; Reviewed; Region: aroK; PRK00131 931276015533 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 931276015534 ADP binding site [chemical binding]; other site 931276015535 magnesium binding site [ion binding]; other site 931276015536 putative shikimate binding site; other site 931276015537 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 931276015538 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 931276015539 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 931276015540 shikimate binding site; other site 931276015541 NAD(P) binding site [chemical binding]; other site 931276015542 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 931276015543 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 931276015544 Prephenate dehydratase; Region: PDT; pfam00800 931276015545 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 931276015546 putative L-Phe binding site [chemical binding]; other site 931276015547 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 931276015548 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 931276015549 Tetramer interface [polypeptide binding]; other site 931276015550 active site 931276015551 FMN-binding site [chemical binding]; other site 931276015552 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 931276015553 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 931276015554 hinge; other site 931276015555 active site 931276015556 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 931276015557 active site 931276015558 dimer interface [polypeptide binding]; other site 931276015559 metal binding site [ion binding]; metal-binding site 931276015560 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 931276015561 Pectinesterase; Region: Pectinesterase; pfam01095 931276015562 putative pectinesterase; Region: PLN02432; cl01911 931276015563 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 931276015564 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 931276015565 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 931276015566 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 931276015567 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 931276015568 putative active site [active] 931276015569 catalytic site [active] 931276015570 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 931276015571 putative active site [active] 931276015572 catalytic site [active] 931276015573 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 931276015574 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 931276015575 HIGH motif; other site 931276015576 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 931276015577 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931276015578 active site 931276015579 KMSKS motif; other site 931276015580 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 931276015581 tRNA binding surface [nucleotide binding]; other site 931276015582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276015583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276015584 active site 931276015585 phosphorylation site [posttranslational modification] 931276015586 intermolecular recognition site; other site 931276015587 dimerization interface [polypeptide binding]; other site 931276015588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276015589 DNA binding site [nucleotide binding] 931276015590 HAMP domain; Region: HAMP; pfam00672 931276015591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276015592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276015593 dimer interface [polypeptide binding]; other site 931276015594 phosphorylation site [posttranslational modification] 931276015595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276015596 ATP binding site [chemical binding]; other site 931276015597 Mg2+ binding site [ion binding]; other site 931276015598 G-X-G motif; other site 931276015599 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 931276015600 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 931276015601 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 931276015602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276015603 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 931276015604 Walker A motif; other site 931276015605 ATP binding site [chemical binding]; other site 931276015606 Walker B motif; other site 931276015607 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931276015608 synthetase active site [active] 931276015609 NTP binding site [chemical binding]; other site 931276015610 metal binding site [ion binding]; metal-binding site 931276015611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 931276015612 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 931276015613 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276015614 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276015615 dimer interface [polypeptide binding]; other site 931276015616 putative CheW interface [polypeptide binding]; other site 931276015617 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 931276015618 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931276015619 active site 931276015620 metal binding site [ion binding]; metal-binding site 931276015621 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 931276015622 butyrate kinase; Provisional; Region: PRK03011 931276015623 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 931276015624 Coat F domain; Region: Coat_F; pfam07875 931276015625 Coat F domain; Region: Coat_F; pfam07875 931276015626 YCII-related domain; Region: YCII; cl00999 931276015627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931276015628 Coenzyme A binding pocket [chemical binding]; other site 931276015629 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931276015630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276015631 DNA-binding site [nucleotide binding]; DNA binding site 931276015632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931276015633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276015634 homodimer interface [polypeptide binding]; other site 931276015635 catalytic residue [active] 931276015636 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 931276015637 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 931276015638 active site 931276015639 HIGH motif; other site 931276015640 dimer interface [polypeptide binding]; other site 931276015641 KMSKS motif; other site 931276015642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931276015643 RNA binding surface [nucleotide binding]; other site 931276015644 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276015645 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276015646 DNA binding site [nucleotide binding] 931276015647 domain linker motif; other site 931276015648 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276015649 dimerization interface [polypeptide binding]; other site 931276015650 ligand binding site [chemical binding]; other site 931276015651 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 931276015652 Divergent AAA domain; Region: AAA_4; pfam04326 931276015653 GAF domain; Region: GAF_3; pfam13492 931276015654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931276015655 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276015656 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276015657 metal binding site [ion binding]; metal-binding site 931276015658 active site 931276015659 I-site; other site 931276015660 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 931276015661 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 931276015662 active site 931276015663 tetramer interface; other site 931276015664 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 931276015665 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 931276015666 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 931276015667 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931276015668 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 931276015669 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 931276015670 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931276015671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931276015672 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 931276015673 UDP-glucose 4-epimerase; Region: PLN02240 931276015674 NAD binding site [chemical binding]; other site 931276015675 homodimer interface [polypeptide binding]; other site 931276015676 active site 931276015677 substrate binding site [chemical binding]; other site 931276015678 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 931276015679 active site 931276015680 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 931276015681 homodimer interface [polypeptide binding]; other site 931276015682 Domain of unknown function (DUF1919); Region: DUF1919; pfam08942 931276015683 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 931276015684 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 931276015685 NAD(P) binding site [chemical binding]; other site 931276015686 homodimer interface [polypeptide binding]; other site 931276015687 substrate binding site [chemical binding]; other site 931276015688 active site 931276015689 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 931276015690 active site 931276015691 LicD family; Region: LicD; pfam04991 931276015692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931276015693 active site 931276015694 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015695 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015696 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015697 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 931276015698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 931276015699 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 931276015700 DHHW protein; Region: DHHW; pfam14286 931276015701 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 931276015702 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931276015703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276015704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015705 dimer interface [polypeptide binding]; other site 931276015706 conserved gate region; other site 931276015707 putative PBP binding loops; other site 931276015708 ABC-ATPase subunit interface; other site 931276015709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276015710 dimer interface [polypeptide binding]; other site 931276015711 conserved gate region; other site 931276015712 putative PBP binding loops; other site 931276015713 ABC-ATPase subunit interface; other site 931276015714 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276015715 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 931276015716 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276015717 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276015718 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276015719 active site 931276015720 P-loop; other site 931276015721 phosphorylation site [posttranslational modification] 931276015722 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276015723 methionine cluster; other site 931276015724 active site 931276015725 phosphorylation site [posttranslational modification] 931276015726 metal binding site [ion binding]; metal-binding site 931276015727 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 931276015728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276015729 Walker A motif; other site 931276015730 ATP binding site [chemical binding]; other site 931276015731 Walker B motif; other site 931276015732 arginine finger; other site 931276015733 Transcriptional antiterminator [Transcription]; Region: COG3933 931276015734 PRD domain; Region: PRD; pfam00874 931276015735 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 931276015736 active pocket/dimerization site; other site 931276015737 active site 931276015738 phosphorylation site [posttranslational modification] 931276015739 PRD domain; Region: PRD; pfam00874 931276015740 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276015741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276015742 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276015743 putative active site [active] 931276015744 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 931276015745 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 931276015746 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 931276015747 beta-galactosidase; Region: BGL; TIGR03356 931276015748 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931276015749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276015750 active site 931276015751 motif I; other site 931276015752 motif II; other site 931276015753 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276015754 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 931276015755 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 931276015756 NAD binding site [chemical binding]; other site 931276015757 sugar binding site [chemical binding]; other site 931276015758 divalent metal binding site [ion binding]; other site 931276015759 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276015760 dimer interface [polypeptide binding]; other site 931276015761 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 931276015762 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931276015763 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931276015764 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931276015765 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 931276015766 active site 931276015767 P-loop; other site 931276015768 phosphorylation site [posttranslational modification] 931276015769 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 931276015770 active site 931276015771 methionine cluster; other site 931276015772 phosphorylation site [posttranslational modification] 931276015773 metal binding site [ion binding]; metal-binding site 931276015774 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 931276015775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276015776 Walker A motif; other site 931276015777 ATP binding site [chemical binding]; other site 931276015778 Walker B motif; other site 931276015779 arginine finger; other site 931276015780 Transcriptional antiterminator [Transcription]; Region: COG3933 931276015781 PRD domain; Region: PRD; pfam00874 931276015782 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 931276015783 active pocket/dimerization site; other site 931276015784 active site 931276015785 phosphorylation site [posttranslational modification] 931276015786 PRD domain; Region: PRD; pfam00874 931276015787 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276015788 dimerization interface [polypeptide binding]; other site 931276015789 PAS fold; Region: PAS; pfam00989 931276015790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931276015791 putative active site [active] 931276015792 heme pocket [chemical binding]; other site 931276015793 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276015794 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276015795 metal binding site [ion binding]; metal-binding site 931276015796 active site 931276015797 I-site; other site 931276015798 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276015799 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 931276015800 EamA-like transporter family; Region: EamA; pfam00892 931276015801 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931276015802 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 931276015803 EamA-like transporter family; Region: EamA; cl17759 931276015804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276015805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931276015806 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 931276015807 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 931276015808 active site 931276015809 metal-binding site 931276015810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 931276015811 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 931276015812 active site 931276015813 metal-binding site 931276015814 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 931276015815 Phosphotransferase enzyme family; Region: APH; pfam01636 931276015816 active site 931276015817 ATP binding site [chemical binding]; other site 931276015818 substrate binding site [chemical binding]; other site 931276015819 dimer interface [polypeptide binding]; other site 931276015820 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015821 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015822 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 931276015823 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015824 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015825 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015826 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015827 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015828 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 931276015829 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931276015830 active site 931276015831 metal binding site [ion binding]; metal-binding site 931276015832 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 931276015833 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 931276015834 G1 box; other site 931276015835 putative GEF interaction site [polypeptide binding]; other site 931276015836 GTP/Mg2+ binding site [chemical binding]; other site 931276015837 Switch I region; other site 931276015838 G2 box; other site 931276015839 G3 box; other site 931276015840 Switch II region; other site 931276015841 G4 box; other site 931276015842 G5 box; other site 931276015843 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 931276015844 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015845 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931276015846 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015847 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 931276015848 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 931276015849 YugN-like family; Region: YugN; pfam08868 931276015850 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015851 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015852 CHASE4 domain; Region: CHASE4; pfam05228 931276015853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931276015854 dimerization interface [polypeptide binding]; other site 931276015855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276015856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276015857 metal binding site [ion binding]; metal-binding site 931276015858 active site 931276015859 I-site; other site 931276015860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276015861 Zn2+ binding site [ion binding]; other site 931276015862 Mg2+ binding site [ion binding]; other site 931276015863 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276015864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276015865 dimer interface [polypeptide binding]; other site 931276015866 putative CheW interface [polypeptide binding]; other site 931276015867 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015868 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015869 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015870 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276015871 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015872 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015873 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015874 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015875 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276015876 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 931276015877 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276015878 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276015879 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015880 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276015881 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276015882 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276015883 Archaeal ATPase; Region: Arch_ATPase; pfam01637 931276015884 AAA ATPase domain; Region: AAA_16; pfam13191 931276015885 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 931276015886 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276015887 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276015888 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 931276015889 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 931276015890 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 931276015891 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 931276015892 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 931276015893 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 931276015894 Ligand binding site; other site 931276015895 Putative Catalytic site; other site 931276015896 DXD motif; other site 931276015897 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 931276015898 extended (e) SDRs; Region: SDR_e; cd08946 931276015899 NAD(P) binding site [chemical binding]; other site 931276015900 active site 931276015901 substrate binding site [chemical binding]; other site 931276015902 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 931276015903 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931276015904 PYR/PP interface [polypeptide binding]; other site 931276015905 dimer interface [polypeptide binding]; other site 931276015906 TPP binding site [chemical binding]; other site 931276015907 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 931276015908 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 931276015909 TPP-binding site [chemical binding]; other site 931276015910 Predicted membrane protein [Function unknown]; Region: COG2246 931276015911 GtrA-like protein; Region: GtrA; pfam04138 931276015912 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 931276015913 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931276015914 inhibitor-cofactor binding pocket; inhibition site 931276015915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276015916 catalytic residue [active] 931276015917 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 931276015918 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 931276015919 NAD binding site [chemical binding]; other site 931276015920 homotetramer interface [polypeptide binding]; other site 931276015921 homodimer interface [polypeptide binding]; other site 931276015922 substrate binding site [chemical binding]; other site 931276015923 active site 931276015924 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 931276015925 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 931276015926 substrate binding site; other site 931276015927 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 931276015928 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 931276015929 Ligand binding site; other site 931276015930 Putative Catalytic site; other site 931276015931 DXD motif; other site 931276015932 WxcM-like, C-terminal; Region: FdtA; pfam05523 931276015933 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 931276015934 putative trimer interface [polypeptide binding]; other site 931276015935 putative CoA binding site [chemical binding]; other site 931276015936 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 931276015937 putative trimer interface [polypeptide binding]; other site 931276015938 putative active site [active] 931276015939 putative substrate binding site [chemical binding]; other site 931276015940 putative CoA binding site [chemical binding]; other site 931276015941 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 931276015942 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931276015943 inhibitor-cofactor binding pocket; inhibition site 931276015944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276015945 catalytic residue [active] 931276015946 Methyltransferase domain; Region: Methyltransf_11; pfam08241 931276015947 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 931276015948 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 931276015949 Probable Catalytic site; other site 931276015950 metal-binding site 931276015951 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 931276015952 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931276015953 Probable Catalytic site; other site 931276015954 metal-binding site 931276015955 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 931276015956 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 931276015957 Walker A/P-loop; other site 931276015958 ATP binding site [chemical binding]; other site 931276015959 Q-loop/lid; other site 931276015960 ABC transporter signature motif; other site 931276015961 Walker B; other site 931276015962 D-loop; other site 931276015963 H-loop/switch region; other site 931276015964 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 931276015965 putative carbohydrate binding site [chemical binding]; other site 931276015966 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 931276015967 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931276015968 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 931276015969 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 931276015970 NADP binding site [chemical binding]; other site 931276015971 active site 931276015972 putative substrate binding site [chemical binding]; other site 931276015973 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931276015974 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 931276015975 Probable Catalytic site; other site 931276015976 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 931276015977 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 931276015978 NAD binding site [chemical binding]; other site 931276015979 substrate binding site [chemical binding]; other site 931276015980 homodimer interface [polypeptide binding]; other site 931276015981 active site 931276015982 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 931276015983 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 931276015984 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 931276015985 substrate binding site; other site 931276015986 tetramer interface; other site 931276015987 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 931276015988 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931276015989 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 931276015990 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931276015991 Probable Catalytic site; other site 931276015992 metal-binding site 931276015993 O-Antigen ligase; Region: Wzy_C; pfam04932 931276015994 O-Antigen ligase; Region: Wzy_C; pfam04932 931276015995 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 931276015996 four helix bundle protein; Region: TIGR02436 931276015997 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276015998 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 931276015999 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276016000 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276016001 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276016002 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276016003 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276016004 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276016005 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276016006 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276016007 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276016008 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931276016009 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276016010 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276016011 Uncharacterized conserved protein [Function unknown]; Region: COG1284 931276016012 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 931276016013 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 931276016014 Cache domain; Region: Cache_1; pfam02743 931276016015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931276016016 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276016017 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016018 dimer interface [polypeptide binding]; other site 931276016019 putative CheW interface [polypeptide binding]; other site 931276016020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276016021 Putative glucoamylase; Region: Glycoamylase; pfam10091 931276016022 Putative glucoamylase; Region: Glycoamylase; pfam10091 931276016023 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 931276016024 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 931276016025 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 931276016026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 931276016027 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 931276016028 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 931276016029 active site 931276016030 metal binding site [ion binding]; metal-binding site 931276016031 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 931276016032 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 931276016033 dimer interface [polypeptide binding]; other site 931276016034 active site 931276016035 catalytic residue [active] 931276016036 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 931276016037 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 931276016038 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 931276016039 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931276016040 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931276016041 Walker A/P-loop; other site 931276016042 ATP binding site [chemical binding]; other site 931276016043 Q-loop/lid; other site 931276016044 ABC transporter signature motif; other site 931276016045 Walker B; other site 931276016046 D-loop; other site 931276016047 H-loop/switch region; other site 931276016048 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931276016049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276016050 dimer interface [polypeptide binding]; other site 931276016051 conserved gate region; other site 931276016052 putative PBP binding loops; other site 931276016053 ABC-ATPase subunit interface; other site 931276016054 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 931276016055 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 931276016056 metal binding site [ion binding]; metal-binding site 931276016057 dimer interface [polypeptide binding]; other site 931276016058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931276016059 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931276016060 substrate binding pocket [chemical binding]; other site 931276016061 membrane-bound complex binding site; other site 931276016062 hinge residues; other site 931276016063 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 931276016064 Part of AAA domain; Region: AAA_19; pfam13245 931276016065 FtsH Extracellular; Region: FtsH_ext; pfam06480 931276016066 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 931276016067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276016068 Walker A motif; other site 931276016069 ATP binding site [chemical binding]; other site 931276016070 Walker B motif; other site 931276016071 arginine finger; other site 931276016072 Peptidase family M41; Region: Peptidase_M41; pfam01434 931276016073 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 931276016074 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 931276016075 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 931276016076 Catalytic site [active] 931276016077 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 931276016078 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 931276016079 Catalytic site [active] 931276016080 diaminopimelate decarboxylase; Region: lysA; TIGR01048 931276016081 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 931276016082 active site 931276016083 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931276016084 substrate binding site [chemical binding]; other site 931276016085 catalytic residues [active] 931276016086 dimer interface [polypeptide binding]; other site 931276016087 Class I aldolases; Region: Aldolase_Class_I; cl17187 931276016088 Class I aldolases; Region: Aldolase_Class_I; cl17187 931276016089 catalytic residue [active] 931276016090 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 931276016091 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 931276016092 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 931276016093 DHHA1 domain; Region: DHHA1; pfam02272 931276016094 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931276016095 metal-binding site [ion binding] 931276016096 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 931276016097 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931276016098 metal-binding site [ion binding] 931276016099 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 931276016100 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931276016101 metal-binding site [ion binding] 931276016102 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276016103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276016104 motif II; other site 931276016105 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 931276016106 putative homotetramer interface [polypeptide binding]; other site 931276016107 putative homodimer interface [polypeptide binding]; other site 931276016108 putative allosteric switch controlling residues; other site 931276016109 putative metal binding site [ion binding]; other site 931276016110 putative homodimer-homodimer interface [polypeptide binding]; other site 931276016111 PAS fold; Region: PAS_4; pfam08448 931276016112 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276016113 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276016114 metal binding site [ion binding]; metal-binding site 931276016115 active site 931276016116 I-site; other site 931276016117 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931276016118 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276016119 Zn2+ binding site [ion binding]; other site 931276016120 Mg2+ binding site [ion binding]; other site 931276016121 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 931276016122 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 931276016123 metal binding site [ion binding]; metal-binding site 931276016124 dimer interface [polypeptide binding]; other site 931276016125 CAAX protease self-immunity; Region: Abi; pfam02517 931276016126 Predicted amidohydrolase [General function prediction only]; Region: COG0388 931276016127 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 931276016128 active site 931276016129 catalytic triad [active] 931276016130 dimer interface [polypeptide binding]; other site 931276016131 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 931276016132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016133 dimerization interface [polypeptide binding]; other site 931276016134 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276016135 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016136 dimer interface [polypeptide binding]; other site 931276016137 putative CheW interface [polypeptide binding]; other site 931276016138 Response regulator receiver domain; Region: Response_reg; pfam00072 931276016139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016140 active site 931276016141 phosphorylation site [posttranslational modification] 931276016142 intermolecular recognition site; other site 931276016143 dimerization interface [polypeptide binding]; other site 931276016144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 931276016145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276016146 dimer interface [polypeptide binding]; other site 931276016147 phosphorylation site [posttranslational modification] 931276016148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276016149 ATP binding site [chemical binding]; other site 931276016150 Mg2+ binding site [ion binding]; other site 931276016151 G-X-G motif; other site 931276016152 Response regulator receiver domain; Region: Response_reg; pfam00072 931276016153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016154 active site 931276016155 phosphorylation site [posttranslational modification] 931276016156 intermolecular recognition site; other site 931276016157 dimerization interface [polypeptide binding]; other site 931276016158 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276016159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016160 dimerization interface [polypeptide binding]; other site 931276016161 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276016162 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016163 dimer interface [polypeptide binding]; other site 931276016164 putative CheW interface [polypeptide binding]; other site 931276016165 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931276016166 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016167 dimer interface [polypeptide binding]; other site 931276016168 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276016169 putative CheW interface [polypeptide binding]; other site 931276016170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931276016171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016172 active site 931276016173 phosphorylation site [posttranslational modification] 931276016174 intermolecular recognition site; other site 931276016175 dimerization interface [polypeptide binding]; other site 931276016176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931276016177 DNA binding residues [nucleotide binding] 931276016178 dimerization interface [polypeptide binding]; other site 931276016179 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 931276016180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016181 active site 931276016182 phosphorylation site [posttranslational modification] 931276016183 intermolecular recognition site; other site 931276016184 dimerization interface [polypeptide binding]; other site 931276016185 CheB methylesterase; Region: CheB_methylest; pfam01339 931276016186 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 931276016187 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 931276016188 baseplate wedge subunit; Provisional; Region: 7; PHA02579 931276016189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276016190 S-adenosylmethionine binding site [chemical binding]; other site 931276016191 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276016192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016193 dimerization interface [polypeptide binding]; other site 931276016194 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016195 dimer interface [polypeptide binding]; other site 931276016196 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931276016197 putative CheW interface [polypeptide binding]; other site 931276016198 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 931276016199 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 931276016200 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 931276016201 ligand binding site [chemical binding]; other site 931276016202 flagellar motor protein MotA; Validated; Region: PRK08124 931276016203 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 931276016204 Predicted membrane protein [Function unknown]; Region: COG2323 931276016205 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 931276016206 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 931276016207 beta-galactosidase; Region: BGL; TIGR03356 931276016208 Rubrerythrin [Energy production and conversion]; Region: COG1592 931276016209 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 931276016210 binuclear metal center [ion binding]; other site 931276016211 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931276016212 iron binding site [ion binding]; other site 931276016213 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 931276016214 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276016215 DNA binding residues [nucleotide binding] 931276016216 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931276016217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016218 active site 931276016219 phosphorylation site [posttranslational modification] 931276016220 intermolecular recognition site; other site 931276016221 dimerization interface [polypeptide binding]; other site 931276016222 LytTr DNA-binding domain; Region: LytTR; smart00850 931276016223 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276016224 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 931276016225 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 931276016226 putative active site [active] 931276016227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276016228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016229 Walker A/P-loop; other site 931276016230 ATP binding site [chemical binding]; other site 931276016231 Q-loop/lid; other site 931276016232 ABC transporter signature motif; other site 931276016233 Walker B; other site 931276016234 D-loop; other site 931276016235 H-loop/switch region; other site 931276016236 acyl-CoA synthetase; Validated; Region: PRK05850 931276016237 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931276016238 acyl-activating enzyme (AAE) consensus motif; other site 931276016239 AMP binding site [chemical binding]; other site 931276016240 active site 931276016241 CoA binding site [chemical binding]; other site 931276016242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931276016243 thioester reductase domain; Region: Thioester-redct; TIGR01746 931276016244 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 931276016245 putative NAD(P) binding site [chemical binding]; other site 931276016246 active site 931276016247 putative substrate binding site [chemical binding]; other site 931276016248 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 931276016249 multiple promoter invertase; Provisional; Region: mpi; PRK13413 931276016250 Presynaptic Site I dimer interface [polypeptide binding]; other site 931276016251 catalytic residues [active] 931276016252 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 931276016253 Synaptic Flat tetramer interface [polypeptide binding]; other site 931276016254 Synaptic Site I dimer interface [polypeptide binding]; other site 931276016255 DNA binding site [nucleotide binding] 931276016256 TRAM domain; Region: TRAM; cl01282 931276016257 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 931276016258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276016259 S-adenosylmethionine binding site [chemical binding]; other site 931276016260 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 931276016261 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 931276016262 domain interfaces; other site 931276016263 active site 931276016264 6-phosphofructokinase; Provisional; Region: PRK03202 931276016265 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 931276016266 active site 931276016267 ADP/pyrophosphate binding site [chemical binding]; other site 931276016268 dimerization interface [polypeptide binding]; other site 931276016269 allosteric effector site; other site 931276016270 fructose-1,6-bisphosphate binding site; other site 931276016271 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 931276016272 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 931276016273 active site 931276016274 PHP Thumb interface [polypeptide binding]; other site 931276016275 metal binding site [ion binding]; metal-binding site 931276016276 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 931276016277 generic binding surface II; other site 931276016278 generic binding surface I; other site 931276016279 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 931276016280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 931276016281 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 931276016282 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 931276016283 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 931276016284 putative substrate binding pocket [chemical binding]; other site 931276016285 dimer interface [polypeptide binding]; other site 931276016286 phosphate binding site [ion binding]; other site 931276016287 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 931276016288 shikimate kinase; Provisional; Region: PRK13947 931276016289 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 931276016290 FAD binding domain; Region: FAD_binding_4; pfam01565 931276016291 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 931276016292 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 931276016293 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 931276016294 GIY-YIG motif/motif A; other site 931276016295 active site 931276016296 catalytic site [active] 931276016297 putative DNA binding site [nucleotide binding]; other site 931276016298 metal binding site [ion binding]; metal-binding site 931276016299 UvrB/uvrC motif; Region: UVR; pfam02151 931276016300 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 931276016301 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931276016302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 931276016303 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 931276016304 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 931276016305 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 931276016306 phosphopeptide binding site; other site 931276016307 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 931276016308 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 931276016309 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 931276016310 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 931276016311 excinuclease ABC subunit B; Provisional; Region: PRK05298 931276016312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276016313 ATP binding site [chemical binding]; other site 931276016314 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276016315 nucleotide binding region [chemical binding]; other site 931276016316 ATP-binding site [chemical binding]; other site 931276016317 Ultra-violet resistance protein B; Region: UvrB; pfam12344 931276016318 UvrB/uvrC motif; Region: UVR; pfam02151 931276016319 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 931276016320 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 931276016321 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 931276016322 protein binding site [polypeptide binding]; other site 931276016323 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 931276016324 Catalytic dyad [active] 931276016325 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 931276016326 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 931276016327 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 931276016328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016329 Walker A/P-loop; other site 931276016330 ATP binding site [chemical binding]; other site 931276016331 Q-loop/lid; other site 931276016332 ABC transporter signature motif; other site 931276016333 Walker B; other site 931276016334 D-loop; other site 931276016335 H-loop/switch region; other site 931276016336 Uncharacterized conserved protein [Function unknown]; Region: COG1284 931276016337 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 931276016338 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 931276016339 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 931276016340 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931276016341 PYR/PP interface [polypeptide binding]; other site 931276016342 dimer interface [polypeptide binding]; other site 931276016343 TPP binding site [chemical binding]; other site 931276016344 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931276016345 transketolase; Reviewed; Region: PRK05899 931276016346 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931276016347 TPP-binding site [chemical binding]; other site 931276016348 dimer interface [polypeptide binding]; other site 931276016349 PemK-like protein; Region: PemK; pfam02452 931276016350 putative carbohydrate kinase; Provisional; Region: PRK10565 931276016351 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 931276016352 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 931276016353 putative substrate binding site [chemical binding]; other site 931276016354 putative ATP binding site [chemical binding]; other site 931276016355 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 931276016356 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 931276016357 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 931276016358 dimer interface [polypeptide binding]; other site 931276016359 ssDNA binding site [nucleotide binding]; other site 931276016360 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276016361 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 931276016362 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 931276016363 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 931276016364 DltD central region; Region: DltD_M; pfam04918 931276016365 DltD C-terminal region; Region: DltD_C; pfam04914 931276016366 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 931276016367 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 931276016368 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 931276016369 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 931276016370 putative trimer interface [polypeptide binding]; other site 931276016371 putative CoA binding site [chemical binding]; other site 931276016372 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 931276016373 putative trimer interface [polypeptide binding]; other site 931276016374 putative active site [active] 931276016375 putative substrate binding site [chemical binding]; other site 931276016376 putative CoA binding site [chemical binding]; other site 931276016377 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 931276016378 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931276016379 inhibitor-cofactor binding pocket; inhibition site 931276016380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931276016381 catalytic residue [active] 931276016382 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 931276016383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931276016384 ATP binding site [chemical binding]; other site 931276016385 DEAD_2; Region: DEAD_2; pfam06733 931276016386 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 931276016387 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 931276016388 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 931276016389 Predicted methyltransferases [General function prediction only]; Region: COG0313 931276016390 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 931276016391 putative SAM binding site [chemical binding]; other site 931276016392 putative homodimer interface [polypeptide binding]; other site 931276016393 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 931276016394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276016395 S-adenosylmethionine binding site [chemical binding]; other site 931276016396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 931276016397 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 931276016398 NlpC/P60 family; Region: NLPC_P60; pfam00877 931276016399 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 931276016400 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931276016401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276016402 motif II; other site 931276016403 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 931276016404 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 931276016405 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 931276016406 ligand binding site [chemical binding]; other site 931276016407 active site 931276016408 UGI interface [polypeptide binding]; other site 931276016409 catalytic site [active] 931276016410 Protein of unknown function (DUF3785); Region: DUF3785; pfam12653 931276016411 NAD-dependent deacetylase; Provisional; Region: PRK00481 931276016412 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 931276016413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276016414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016415 active site 931276016416 phosphorylation site [posttranslational modification] 931276016417 intermolecular recognition site; other site 931276016418 dimerization interface [polypeptide binding]; other site 931276016419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276016420 DNA binding site [nucleotide binding] 931276016421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276016422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276016423 dimer interface [polypeptide binding]; other site 931276016424 phosphorylation site [posttranslational modification] 931276016425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276016426 ATP binding site [chemical binding]; other site 931276016427 Mg2+ binding site [ion binding]; other site 931276016428 G-X-G motif; other site 931276016429 competence damage-inducible protein A; Provisional; Region: PRK00549 931276016430 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 931276016431 putative MPT binding site; other site 931276016432 Competence-damaged protein; Region: CinA; pfam02464 931276016433 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931276016434 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931276016435 nucleotide binding site [chemical binding]; other site 931276016436 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 931276016437 elongation factor G; Reviewed; Region: PRK12740 931276016438 G1 box; other site 931276016439 putative GEF interaction site [polypeptide binding]; other site 931276016440 GTP/Mg2+ binding site [chemical binding]; other site 931276016441 Switch I region; other site 931276016442 G2 box; other site 931276016443 G3 box; other site 931276016444 Switch II region; other site 931276016445 G4 box; other site 931276016446 G5 box; other site 931276016447 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 931276016448 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 931276016449 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 931276016450 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 931276016451 Sulfatase; Region: Sulfatase; pfam00884 931276016452 Predicted integral membrane protein [Function unknown]; Region: COG5652 931276016453 PEP synthetase regulatory protein; Provisional; Region: PRK05339 931276016454 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 931276016455 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 931276016456 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 931276016457 NAD binding site [chemical binding]; other site 931276016458 dimer interface [polypeptide binding]; other site 931276016459 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276016460 substrate binding site [chemical binding]; other site 931276016461 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 931276016462 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 931276016463 ligand binding site; other site 931276016464 oligomer interface; other site 931276016465 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 931276016466 dimer interface [polypeptide binding]; other site 931276016467 N-terminal domain interface [polypeptide binding]; other site 931276016468 sulfate 1 binding site; other site 931276016469 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 931276016470 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 931276016471 ligand binding site; other site 931276016472 oligomer interface; other site 931276016473 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 931276016474 dimer interface [polypeptide binding]; other site 931276016475 N-terminal domain interface [polypeptide binding]; other site 931276016476 sulfate 1 binding site; other site 931276016477 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 931276016478 homodimer interface [polypeptide binding]; other site 931276016479 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 931276016480 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 931276016481 active site 931276016482 homodimer interface [polypeptide binding]; other site 931276016483 catalytic site [active] 931276016484 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 931276016485 homodimer interface [polypeptide binding]; other site 931276016486 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 931276016487 active site pocket [active] 931276016488 glycogen synthase; Provisional; Region: glgA; PRK00654 931276016489 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 931276016490 ADP-binding pocket [chemical binding]; other site 931276016491 homodimer interface [polypeptide binding]; other site 931276016492 glycogen branching enzyme; Provisional; Region: PRK12313 931276016493 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 931276016494 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 931276016495 active site 931276016496 catalytic site [active] 931276016497 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 931276016498 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 931276016499 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 931276016500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931276016501 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 931276016502 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 931276016503 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 931276016504 active site 931276016505 phosphorylation site [posttranslational modification] 931276016506 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 931276016507 active pocket/dimerization site; other site 931276016508 active site 931276016509 phosphorylation site [posttranslational modification] 931276016510 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 931276016511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276016512 Walker A motif; other site 931276016513 ATP binding site [chemical binding]; other site 931276016514 Walker B motif; other site 931276016515 arginine finger; other site 931276016516 Transcriptional antiterminator [Transcription]; Region: COG3933 931276016517 PRD domain; Region: PRD; pfam00874 931276016518 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 931276016519 active pocket/dimerization site; other site 931276016520 active site 931276016521 phosphorylation site [posttranslational modification] 931276016522 PRD domain; Region: PRD; pfam00874 931276016523 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 931276016524 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 931276016525 putative ATP binding site [chemical binding]; other site 931276016526 putative substrate interface [chemical binding]; other site 931276016527 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 931276016528 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 931276016529 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276016530 CHASE3 domain; Region: CHASE3; cl05000 931276016531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016532 dimerization interface [polypeptide binding]; other site 931276016533 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276016534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016535 dimer interface [polypeptide binding]; other site 931276016536 putative CheW interface [polypeptide binding]; other site 931276016537 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276016538 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276016539 Ion channel; Region: Ion_trans_2; pfam07885 931276016540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931276016541 active site 931276016542 AAA domain; Region: AAA_21; pfam13304 931276016543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016544 Walker A/P-loop; other site 931276016545 ATP binding site [chemical binding]; other site 931276016546 ABC transporter signature motif; other site 931276016547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 931276016548 Walker B; other site 931276016549 Walker B; other site 931276016550 D-loop; other site 931276016551 D-loop; other site 931276016552 H-loop/switch region; other site 931276016553 H-loop/switch region; other site 931276016554 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 931276016555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276016556 Zn2+ binding site [ion binding]; other site 931276016557 Mg2+ binding site [ion binding]; other site 931276016558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931276016559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016560 active site 931276016561 phosphorylation site [posttranslational modification] 931276016562 intermolecular recognition site; other site 931276016563 dimerization interface [polypeptide binding]; other site 931276016564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931276016565 DNA binding site [nucleotide binding] 931276016566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276016567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016568 dimerization interface [polypeptide binding]; other site 931276016569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931276016570 dimer interface [polypeptide binding]; other site 931276016571 phosphorylation site [posttranslational modification] 931276016572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276016573 ATP binding site [chemical binding]; other site 931276016574 Mg2+ binding site [ion binding]; other site 931276016575 G-X-G motif; other site 931276016576 Cache domain; Region: Cache_1; pfam02743 931276016577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016578 dimerization interface [polypeptide binding]; other site 931276016579 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276016580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016581 dimer interface [polypeptide binding]; other site 931276016582 putative CheW interface [polypeptide binding]; other site 931276016583 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931276016584 Nitroreductase family; Region: Nitroreductase; pfam00881 931276016585 FMN binding site [chemical binding]; other site 931276016586 dimer interface [polypeptide binding]; other site 931276016587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931276016588 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 931276016589 putative hydrophobic ligand binding site [chemical binding]; other site 931276016590 Uncharacterized conserved protein [Function unknown]; Region: COG4198 931276016591 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 931276016592 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 931276016593 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 931276016594 putative ligand binding site [chemical binding]; other site 931276016595 NAD binding site [chemical binding]; other site 931276016596 dimerization interface [polypeptide binding]; other site 931276016597 catalytic site [active] 931276016598 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 931276016599 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 931276016600 active site 931276016601 Zn binding site [ion binding]; other site 931276016602 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 931276016603 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 931276016604 peptide binding site [polypeptide binding]; other site 931276016605 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 931276016606 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276016607 Walker A/P-loop; other site 931276016608 ATP binding site [chemical binding]; other site 931276016609 Q-loop/lid; other site 931276016610 ABC transporter signature motif; other site 931276016611 Walker B; other site 931276016612 D-loop; other site 931276016613 H-loop/switch region; other site 931276016614 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931276016615 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931276016616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931276016617 Walker A/P-loop; other site 931276016618 ATP binding site [chemical binding]; other site 931276016619 Q-loop/lid; other site 931276016620 ABC transporter signature motif; other site 931276016621 Walker B; other site 931276016622 D-loop; other site 931276016623 H-loop/switch region; other site 931276016624 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 931276016625 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 931276016626 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 931276016627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276016628 dimer interface [polypeptide binding]; other site 931276016629 conserved gate region; other site 931276016630 putative PBP binding loops; other site 931276016631 ABC-ATPase subunit interface; other site 931276016632 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931276016633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276016634 dimer interface [polypeptide binding]; other site 931276016635 conserved gate region; other site 931276016636 putative PBP binding loops; other site 931276016637 ABC-ATPase subunit interface; other site 931276016638 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 931276016639 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 931276016640 active site 931276016641 Zn binding site [ion binding]; other site 931276016642 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276016643 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276016644 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276016645 Bacterial SH3 domain; Region: SH3_3; pfam08239 931276016646 CHAP domain; Region: CHAP; pfam05257 931276016647 Surface antigen [General function prediction only]; Region: COG3942 931276016648 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 931276016649 recombination protein RecR; Reviewed; Region: recR; PRK00076 931276016650 RecR protein; Region: RecR; pfam02132 931276016651 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 931276016652 putative active site [active] 931276016653 putative metal-binding site [ion binding]; other site 931276016654 tetramer interface [polypeptide binding]; other site 931276016655 hypothetical protein; Validated; Region: PRK00153 931276016656 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 931276016657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276016658 Walker A motif; other site 931276016659 ATP binding site [chemical binding]; other site 931276016660 Walker B motif; other site 931276016661 arginine finger; other site 931276016662 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 931276016663 thymidylate synthase; Reviewed; Region: thyA; PRK01827 931276016664 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 931276016665 dimerization interface [polypeptide binding]; other site 931276016666 active site 931276016667 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 931276016668 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 931276016669 folate binding site [chemical binding]; other site 931276016670 NADP+ binding site [chemical binding]; other site 931276016671 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 931276016672 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 931276016673 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 931276016674 diiron binding motif [ion binding]; other site 931276016675 CrcB-like protein; Region: CRCB; cl09114 931276016676 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 931276016677 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 931276016678 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 931276016679 Response regulator receiver domain; Region: Response_reg; pfam00072 931276016680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276016681 active site 931276016682 phosphorylation site [posttranslational modification] 931276016683 intermolecular recognition site; other site 931276016684 dimerization interface [polypeptide binding]; other site 931276016685 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 931276016686 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931276016687 Domain of unknown function DUF20; Region: UPF0118; pfam01594 931276016688 pyruvate carboxylase; Reviewed; Region: PRK12999 931276016689 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931276016690 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 931276016691 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 931276016692 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 931276016693 active site 931276016694 catalytic residues [active] 931276016695 metal binding site [ion binding]; metal-binding site 931276016696 homodimer binding site [polypeptide binding]; other site 931276016697 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 931276016698 carboxyltransferase (CT) interaction site; other site 931276016699 biotinylation site [posttranslational modification]; other site 931276016700 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 931276016701 EAL domain; Region: EAL; pfam00563 931276016702 PAS fold; Region: PAS_3; pfam08447 931276016703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276016704 metal binding site [ion binding]; metal-binding site 931276016705 active site 931276016706 I-site; other site 931276016707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931276016708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931276016709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931276016710 metal binding site [ion binding]; metal-binding site 931276016711 active site 931276016712 I-site; other site 931276016713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276016714 Zn2+ binding site [ion binding]; other site 931276016715 Mg2+ binding site [ion binding]; other site 931276016716 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 931276016717 active site 931276016718 catalytic residues [active] 931276016719 DNA binding site [nucleotide binding] 931276016720 Int/Topo IB signature motif; other site 931276016721 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 931276016722 Cache domain; Region: Cache_1; pfam02743 931276016723 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276016724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016725 dimerization interface [polypeptide binding]; other site 931276016726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016727 dimer interface [polypeptide binding]; other site 931276016728 putative CheW interface [polypeptide binding]; other site 931276016729 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 931276016730 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 931276016731 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 931276016732 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 931276016733 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276016734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276016735 DNA binding site [nucleotide binding] 931276016736 domain linker motif; other site 931276016737 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931276016738 dimerization interface [polypeptide binding]; other site 931276016739 ligand binding site [chemical binding]; other site 931276016740 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 931276016741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276016742 dimer interface [polypeptide binding]; other site 931276016743 conserved gate region; other site 931276016744 putative PBP binding loops; other site 931276016745 ABC-ATPase subunit interface; other site 931276016746 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 931276016747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931276016748 dimer interface [polypeptide binding]; other site 931276016749 putative PBP binding loops; other site 931276016750 ABC-ATPase subunit interface; other site 931276016751 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931276016752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 931276016753 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931276016754 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931276016755 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931276016756 putative active site [active] 931276016757 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276016758 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 931276016759 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276016760 active site turn [active] 931276016761 phosphorylation site [posttranslational modification] 931276016762 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 931276016763 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 931276016764 NAD binding site [chemical binding]; other site 931276016765 sugar binding site [chemical binding]; other site 931276016766 divalent metal binding site [ion binding]; other site 931276016767 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276016768 dimer interface [polypeptide binding]; other site 931276016769 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931276016770 HPr interaction site; other site 931276016771 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931276016772 active site 931276016773 phosphorylation site [posttranslational modification] 931276016774 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 931276016775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276016776 S-adenosylmethionine binding site [chemical binding]; other site 931276016777 Transcriptional regulators [Transcription]; Region: FadR; COG2186 931276016778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931276016779 DNA-binding site [nucleotide binding]; DNA binding site 931276016780 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 931276016781 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 931276016782 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 931276016783 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 931276016784 nucleoside/Zn binding site; other site 931276016785 dimer interface [polypeptide binding]; other site 931276016786 catalytic motif [active] 931276016787 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 931276016788 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 931276016789 putative substrate binding site [chemical binding]; other site 931276016790 putative ATP binding site [chemical binding]; other site 931276016791 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 931276016792 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 931276016793 substrate binding [chemical binding]; other site 931276016794 active site 931276016795 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 931276016796 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276016797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276016798 DNA binding site [nucleotide binding] 931276016799 domain linker motif; other site 931276016800 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 931276016801 dimerization interface [polypeptide binding]; other site 931276016802 ligand binding site [chemical binding]; other site 931276016803 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 931276016804 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931276016805 active site turn [active] 931276016806 phosphorylation site [posttranslational modification] 931276016807 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931276016808 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276016809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276016810 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931276016811 Walker A/P-loop; other site 931276016812 ATP binding site [chemical binding]; other site 931276016813 Q-loop/lid; other site 931276016814 ABC transporter signature motif; other site 931276016815 Walker B; other site 931276016816 D-loop; other site 931276016817 H-loop/switch region; other site 931276016818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931276016819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931276016820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016821 Walker A/P-loop; other site 931276016822 ATP binding site [chemical binding]; other site 931276016823 Q-loop/lid; other site 931276016824 ABC transporter signature motif; other site 931276016825 Walker B; other site 931276016826 D-loop; other site 931276016827 H-loop/switch region; other site 931276016828 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931276016829 MarR family; Region: MarR_2; pfam12802 931276016830 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 931276016831 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931276016832 active site 931276016833 metal binding site [ion binding]; metal-binding site 931276016834 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 931276016835 Mg binding site [ion binding]; other site 931276016836 nucleotide binding site [chemical binding]; other site 931276016837 putative protofilament interface [polypeptide binding]; other site 931276016838 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 931276016839 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 931276016840 MutS domain III; Region: MutS_III; pfam05192 931276016841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016842 Walker A/P-loop; other site 931276016843 ATP binding site [chemical binding]; other site 931276016844 Q-loop/lid; other site 931276016845 ABC transporter signature motif; other site 931276016846 Walker B; other site 931276016847 D-loop; other site 931276016848 H-loop/switch region; other site 931276016849 hypothetical protein; Provisional; Region: PRK10281 931276016850 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 931276016851 Predicted transcriptional regulators [Transcription]; Region: COG1733 931276016852 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931276016853 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 931276016854 substrate binding site [chemical binding]; other site 931276016855 active site 931276016856 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 931276016857 LytTr DNA-binding domain; Region: LytTR; smart00850 931276016858 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276016859 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931276016860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276016861 dimerization interface [polypeptide binding]; other site 931276016862 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016863 dimer interface [polypeptide binding]; other site 931276016864 putative CheW interface [polypeptide binding]; other site 931276016865 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 931276016866 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 931276016867 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 931276016868 dimer interface [polypeptide binding]; other site 931276016869 active site 931276016870 metal binding site [ion binding]; metal-binding site 931276016871 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 931276016872 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 931276016873 PGAP1-like protein; Region: PGAP1; pfam07819 931276016874 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931276016875 MarR family; Region: MarR_2; pfam12802 931276016876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016877 Walker A/P-loop; other site 931276016878 ATP binding site [chemical binding]; other site 931276016879 Q-loop/lid; other site 931276016880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016881 ABC transporter signature motif; other site 931276016882 Walker B; other site 931276016883 D-loop; other site 931276016884 H-loop/switch region; other site 931276016885 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 931276016886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931276016887 Walker A/P-loop; other site 931276016888 ATP binding site [chemical binding]; other site 931276016889 Q-loop/lid; other site 931276016890 ABC transporter signature motif; other site 931276016891 Walker B; other site 931276016892 D-loop; other site 931276016893 H-loop/switch region; other site 931276016894 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931276016895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276016896 Epoxide hydrolase N terminus; Region: EHN; pfam06441 931276016897 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931276016898 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 931276016899 putative catalytic cysteine [active] 931276016900 Coenzyme A transferase; Region: CoA_trans; cl17247 931276016901 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 931276016902 acetoacetate decarboxylase; Provisional; Region: PRK02265 931276016903 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 931276016904 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 931276016905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276016906 non-specific DNA binding site [nucleotide binding]; other site 931276016907 salt bridge; other site 931276016908 sequence-specific DNA binding site [nucleotide binding]; other site 931276016909 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931276016910 active site 931276016911 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276016912 active site 931276016913 DNA binding site [nucleotide binding] 931276016914 Int/Topo IB signature motif; other site 931276016915 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931276016916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276016917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276016918 dimer interface [polypeptide binding]; other site 931276016919 putative CheW interface [polypeptide binding]; other site 931276016920 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 931276016921 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276016922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931276016923 ATP binding site [chemical binding]; other site 931276016924 putative Mg++ binding site [ion binding]; other site 931276016925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 931276016926 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 931276016927 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 931276016928 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931276016929 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 931276016930 Helix-turn-helix domain; Region: HTH_17; pfam12728 931276016931 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 931276016932 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 931276016933 catalytic residues [active] 931276016934 catalytic nucleophile [active] 931276016935 Presynaptic Site I dimer interface [polypeptide binding]; other site 931276016936 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 931276016937 Synaptic Flat tetramer interface [polypeptide binding]; other site 931276016938 Synaptic Site I dimer interface [polypeptide binding]; other site 931276016939 DNA binding site [nucleotide binding] 931276016940 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 931276016941 DNA-binding interface [nucleotide binding]; DNA binding site 931276016942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 931276016943 Terminase-like family; Region: Terminase_6; pfam03237 931276016944 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 931276016945 NlpC/P60 family; Region: NLPC_P60; cl17555 931276016946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931276016947 active site 931276016948 replicative DNA helicase; Region: DnaB; TIGR00665 931276016949 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 931276016950 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 931276016951 Walker A motif; other site 931276016952 ATP binding site [chemical binding]; other site 931276016953 Walker B motif; other site 931276016954 DNA binding loops [nucleotide binding] 931276016955 Helix-turn-helix domain; Region: HTH_36; pfam13730 931276016956 Helix-turn-helix domain; Region: HTH_17; pfam12728 931276016957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276016958 sequence-specific DNA binding site [nucleotide binding]; other site 931276016959 salt bridge; other site 931276016960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276016961 non-specific DNA binding site [nucleotide binding]; other site 931276016962 salt bridge; other site 931276016963 sequence-specific DNA binding site [nucleotide binding]; other site 931276016964 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 931276016965 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931276016966 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 931276016967 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 931276016968 Int/Topo IB signature motif; other site 931276016969 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931276016970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276016971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276016972 ABC transporter; Region: ABC_tran_2; pfam12848 931276016973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931276016974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276016975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276016976 putative substrate translocation pore; other site 931276016977 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 931276016978 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931276016979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931276016980 motif II; other site 931276016981 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931276016982 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 931276016983 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 931276016984 putative acyl-acceptor binding pocket; other site 931276016985 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 931276016986 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 931276016987 ATP binding site [chemical binding]; other site 931276016988 Mg++ binding site [ion binding]; other site 931276016989 motif III; other site 931276016990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931276016991 nucleotide binding region [chemical binding]; other site 931276016992 ATP-binding site [chemical binding]; other site 931276016993 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 931276016994 RNA binding site [nucleotide binding]; other site 931276016995 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 931276016996 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931276016997 Zn2+ binding site [ion binding]; other site 931276016998 Mg2+ binding site [ion binding]; other site 931276016999 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931276017000 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931276017001 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931276017002 Phosphotransferase enzyme family; Region: APH; pfam01636 931276017003 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 931276017004 active site 931276017005 ATP binding site [chemical binding]; other site 931276017006 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 931276017007 putative transporter; Provisional; Region: PRK11660 931276017008 Sulfate transporter family; Region: Sulfate_transp; pfam00916 931276017009 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 931276017010 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 931276017011 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 931276017012 dimer interface [polypeptide binding]; other site 931276017013 active site 931276017014 catalytic residue [active] 931276017015 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 931276017016 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 931276017017 predicted active site [active] 931276017018 catalytic triad [active] 931276017019 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 931276017020 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 931276017021 active site 931276017022 multimer interface [polypeptide binding]; other site 931276017023 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 931276017024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931276017025 S-adenosylmethionine binding site [chemical binding]; other site 931276017026 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931276017027 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 931276017028 putative ligand binding site [chemical binding]; other site 931276017029 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931276017030 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 931276017031 TM-ABC transporter signature motif; other site 931276017032 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 931276017033 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 931276017034 TM-ABC transporter signature motif; other site 931276017035 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 931276017036 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 931276017037 Walker A/P-loop; other site 931276017038 ATP binding site [chemical binding]; other site 931276017039 Q-loop/lid; other site 931276017040 ABC transporter signature motif; other site 931276017041 Walker B; other site 931276017042 D-loop; other site 931276017043 H-loop/switch region; other site 931276017044 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 931276017045 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 931276017046 Walker A/P-loop; other site 931276017047 ATP binding site [chemical binding]; other site 931276017048 Q-loop/lid; other site 931276017049 ABC transporter signature motif; other site 931276017050 Walker B; other site 931276017051 D-loop; other site 931276017052 H-loop/switch region; other site 931276017053 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 931276017054 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 931276017055 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 931276017056 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931276017057 ACS interaction site; other site 931276017058 CODH interaction site; other site 931276017059 metal cluster binding site [ion binding]; other site 931276017060 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 931276017061 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 931276017062 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931276017063 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931276017064 Double zinc ribbon; Region: DZR; pfam12773 931276017065 Double zinc ribbon; Region: DZR; pfam12773 931276017066 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 931276017067 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 931276017068 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 931276017069 ligand binding site [chemical binding]; other site 931276017070 Response regulator receiver domain; Region: Response_reg; pfam00072 931276017071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931276017072 active site 931276017073 phosphorylation site [posttranslational modification] 931276017074 intermolecular recognition site; other site 931276017075 dimerization interface [polypeptide binding]; other site 931276017076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931276017077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931276017078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931276017079 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276017080 dimerization interface [polypeptide binding]; other site 931276017081 Histidine kinase; Region: His_kinase; pfam06580 931276017082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931276017083 ATP binding site [chemical binding]; other site 931276017084 Mg2+ binding site [ion binding]; other site 931276017085 G-X-G motif; other site 931276017086 putative transporter; Provisional; Region: PRK10484 931276017087 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 931276017088 Na binding site [ion binding]; other site 931276017089 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276017090 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276017091 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276017092 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 931276017093 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931276017094 Beta-lactamase; Region: Beta-lactamase; pfam00144 931276017095 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931276017096 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931276017097 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 931276017098 putative active site [active] 931276017099 putative metal binding site [ion binding]; other site 931276017100 Putative esterase; Region: Esterase; pfam00756 931276017101 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 931276017102 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 931276017103 Uncharacterized conserved protein [Function unknown]; Region: COG0327 931276017104 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 931276017105 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 931276017106 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 931276017107 putative substrate binding site [chemical binding]; other site 931276017108 putative ATP binding site [chemical binding]; other site 931276017109 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 931276017110 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 931276017111 active site 931276017112 homodimer interface [polypeptide binding]; other site 931276017113 catalytic site [active] 931276017114 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931276017115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931276017116 DNA binding site [nucleotide binding] 931276017117 domain linker motif; other site 931276017118 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 931276017119 dimerization interface [polypeptide binding]; other site 931276017120 ligand binding site [chemical binding]; other site 931276017121 sodium binding site [ion binding]; other site 931276017122 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 931276017123 FAD binding domain; Region: FAD_binding_4; pfam01565 931276017124 Berberine and berberine like; Region: BBE; pfam08031 931276017125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931276017126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931276017127 non-specific DNA binding site [nucleotide binding]; other site 931276017128 salt bridge; other site 931276017129 sequence-specific DNA binding site [nucleotide binding]; other site 931276017130 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 931276017131 homodimer interaction site [polypeptide binding]; other site 931276017132 cofactor binding site; other site 931276017133 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931276017134 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931276017135 DNA binding residues [nucleotide binding] 931276017136 drug binding residues [chemical binding]; other site 931276017137 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931276017138 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 931276017139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276017140 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931276017141 putative substrate translocation pore; other site 931276017142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931276017143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931276017144 dimerization interface [polypeptide binding]; other site 931276017145 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931276017146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931276017147 dimer interface [polypeptide binding]; other site 931276017148 putative CheW interface [polypeptide binding]; other site 931276017149 hypothetical protein; Provisional; Region: PRK05590 931276017150 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 931276017151 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 931276017152 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 931276017153 hinge; other site 931276017154 active site 931276017155 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 931276017156 Protein of unknown function, DUF606; Region: DUF606; pfam04657 931276017157 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931276017158 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 931276017159 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931276017160 active site 931276017161 catalytic residues [active] 931276017162 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 931276017163 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 931276017164 DNA replication protein DnaC; Validated; Region: PRK06835 931276017165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276017166 Walker A motif; other site 931276017167 ATP binding site [chemical binding]; other site 931276017168 flavoprotein, HI0933 family; Region: TIGR00275 931276017169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931276017170 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 931276017171 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 931276017172 active site 931276017173 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 931276017174 active site 2 [active] 931276017175 active site 1 [active] 931276017176 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 931276017177 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 931276017178 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 931276017179 GDP-binding site [chemical binding]; other site 931276017180 ACT binding site; other site 931276017181 IMP binding site; other site 931276017182 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 931276017183 Malic enzyme, N-terminal domain; Region: malic; pfam00390 931276017184 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 931276017185 putative NAD(P) binding site [chemical binding]; other site 931276017186 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 931276017187 pyrroline-5-carboxylate reductase; Region: PLN02688 931276017188 replicative DNA helicase; Provisional; Region: PRK05595 931276017189 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 931276017190 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 931276017191 Walker A motif; other site 931276017192 ATP binding site [chemical binding]; other site 931276017193 Walker B motif; other site 931276017194 DNA binding loops [nucleotide binding] 931276017195 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 931276017196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276017197 Walker A motif; other site 931276017198 ATP binding site [chemical binding]; other site 931276017199 Walker B motif; other site 931276017200 arginine finger; other site 931276017201 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 931276017202 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 931276017203 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 931276017204 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 931276017205 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 931276017206 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 931276017207 DHH family; Region: DHH; pfam01368 931276017208 DHHA1 domain; Region: DHHA1; pfam02272 931276017209 MazG-like family; Region: MazG-like; pfam12643 931276017210 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 931276017211 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 931276017212 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 931276017213 dimer interface [polypeptide binding]; other site 931276017214 ssDNA binding site [nucleotide binding]; other site 931276017215 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931276017216 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 931276017217 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 931276017218 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 931276017219 Mechanosensitive ion channel; Region: MS_channel; pfam00924 931276017220 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 931276017221 LysE type translocator; Region: LysE; cl00565 931276017222 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931276017223 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 931276017224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931276017225 catalytic residue [active] 931276017226 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 931276017227 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 931276017228 ParB-like nuclease domain; Region: ParBc; pfam02195 931276017229 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 931276017230 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931276017231 P-loop; other site 931276017232 Magnesium ion binding site [ion binding]; other site 931276017233 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931276017234 Magnesium ion binding site [ion binding]; other site 931276017235 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 931276017236 ParB-like nuclease domain; Region: ParB; smart00470 931276017237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 931276017238 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 931276017239 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 931276017240 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 931276017241 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 931276017242 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 931276017243 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 931276017244 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 931276017245 trmE is a tRNA modification GTPase; Region: trmE; cd04164 931276017246 G1 box; other site 931276017247 GTP/Mg2+ binding site [chemical binding]; other site 931276017248 Switch I region; other site 931276017249 G2 box; other site 931276017250 Switch II region; other site 931276017251 G3 box; other site 931276017252 G4 box; other site 931276017253 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 931276017254 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 931276017255 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 931276017256 G-X-X-G motif; other site 931276017257 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 931276017258 RxxxH motif; other site 931276017259 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 931276017260 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 931276017261 Haemolytic domain; Region: Haemolytic; pfam01809 931276017262 ribonuclease P; Reviewed; Region: rnpA; PRK00499 931276017263 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 931276017264 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 931276017265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931276017266 P-loop; other site 931276017267 Magnesium ion binding site [ion binding]; other site 931276017268 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931276017269 Magnesium ion binding site [ion binding]; other site 931276017270 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276017271 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276017272 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276017273 Domain of unknown function DUF11; Region: DUF11; cl17728 931276017274 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276017275 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276017276 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 931276017277 dockerin binding interface; other site 931276017278 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931276017279 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931276017280 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 931276017281 Vps51/Vps67; Region: Vps51; pfam08700 931276017282 NlpC/P60 family; Region: NLPC_P60; cl17555 931276017283 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 931276017284 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 931276017285 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 931276017286 N-acetyl-D-glucosamine binding site [chemical binding]; other site 931276017287 catalytic residue [active] 931276017288 Baseplate J-like protein; Region: Baseplate_J; pfam04865 931276017289 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 931276017290 Glycine rich protein; Region: Gly_rich; pfam12810 931276017291 Glycine rich protein; Region: Gly_rich; pfam12810 931276017292 Glycine rich protein; Region: Gly_rich; pfam12810 931276017293 Glycine rich protein; Region: Gly_rich; pfam12810 931276017294 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 931276017295 active site 931276017296 catalytic triad [active] 931276017297 oxyanion hole [active] 931276017298 endonuclease subunit; Provisional; Region: 46; PHA02562 931276017299 Glycine rich protein; Region: Gly_rich; pfam12810 931276017300 Phage Tail Collar Domain; Region: Collar; pfam07484 931276017301 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 931276017302 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931276017303 active site 931276017304 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276017305 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931276017306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931276017307 DNA binding residues [nucleotide binding] 931276017308 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 931276017309 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 931276017310 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 931276017311 Predicted transcriptional regulators [Transcription]; Region: COG1695 931276017312 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931276017313 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276017314 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931276017315 PHP domain; Region: PHP; pfam02811 931276017316 active site 931276017317 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 931276017318 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 931276017319 oligomerisation interface [polypeptide binding]; other site 931276017320 mobile loop; other site 931276017321 roof hairpin; other site 931276017322 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276017323 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276017324 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276017325 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931276017326 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276017327 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276017328 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931276017329 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931276017330 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276017331 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276017332 Transposase domain (DUF772); Region: DUF772; pfam05598 931276017333 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276017334 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 931276017335 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 931276017336 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 931276017337 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 931276017338 metal ion-dependent adhesion site (MIDAS); other site 931276017339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931276017340 Walker A motif; other site 931276017341 ATP binding site [chemical binding]; other site 931276017342 Walker B motif; other site 931276017343 arginine finger; other site 931276017344 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 931276017345 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 931276017346 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872