-- dump date 20140619_045300 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1121335000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1121335000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1121335000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000004 Walker A motif; other site 1121335000005 ATP binding site [chemical binding]; other site 1121335000006 Walker B motif; other site 1121335000007 arginine finger; other site 1121335000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121335000009 DnaA box-binding interface [nucleotide binding]; other site 1121335000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1121335000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1121335000012 putative DNA binding surface [nucleotide binding]; other site 1121335000013 dimer interface [polypeptide binding]; other site 1121335000014 beta-clamp/clamp loader binding surface; other site 1121335000015 beta-clamp/translesion DNA polymerase binding surface; other site 1121335000016 recombination protein F; Reviewed; Region: recF; PRK00064 1121335000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000018 Walker A/P-loop; other site 1121335000019 ATP binding site [chemical binding]; other site 1121335000020 Q-loop/lid; other site 1121335000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000022 ABC transporter signature motif; other site 1121335000023 Walker B; other site 1121335000024 D-loop; other site 1121335000025 H-loop/switch region; other site 1121335000026 Domain of unknown function (DUF370); Region: DUF370; cl00898 1121335000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1121335000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000029 ATP binding site [chemical binding]; other site 1121335000030 Mg2+ binding site [ion binding]; other site 1121335000031 G-X-G motif; other site 1121335000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1121335000033 anchoring element; other site 1121335000034 dimer interface [polypeptide binding]; other site 1121335000035 ATP binding site [chemical binding]; other site 1121335000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1121335000037 active site 1121335000038 putative metal-binding site [ion binding]; other site 1121335000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121335000040 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335000041 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335000042 Integrase core domain; Region: rve; pfam00665 1121335000043 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121335000044 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121335000045 P-loop; other site 1121335000046 Magnesium ion binding site [ion binding]; other site 1121335000047 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121335000048 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1121335000049 ParB-like nuclease domain; Region: ParB; smart00470 1121335000050 seryl-tRNA synthetase; Provisional; Region: PRK05431 1121335000051 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1121335000052 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1121335000053 dimer interface [polypeptide binding]; other site 1121335000054 active site 1121335000055 motif 1; other site 1121335000056 motif 2; other site 1121335000057 motif 3; other site 1121335000058 hypothetical protein; Provisional; Region: PRK03881 1121335000059 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1121335000060 AMMECR1; Region: AMMECR1; pfam01871 1121335000061 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 1121335000062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335000063 FeS/SAM binding site; other site 1121335000064 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1121335000065 active site 1121335000066 8-oxo-dGMP binding site [chemical binding]; other site 1121335000067 nudix motif; other site 1121335000068 metal binding site [ion binding]; metal-binding site 1121335000069 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1121335000070 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1121335000071 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1121335000072 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1121335000073 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1121335000074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1121335000075 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1121335000076 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 1121335000077 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 1121335000078 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1121335000079 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1121335000080 Cl binding site [ion binding]; other site 1121335000081 oligomer interface [polypeptide binding]; other site 1121335000082 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1121335000083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335000084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335000085 DNA binding residues [nucleotide binding] 1121335000086 Putative zinc-finger; Region: zf-HC2; pfam13490 1121335000087 Sporulation and spore germination; Region: Germane; pfam10646 1121335000088 Tubby C 2; Region: Tub_2; cl02043 1121335000089 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1121335000090 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1121335000091 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1121335000092 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121335000093 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1121335000094 putative dimer interface [polypeptide binding]; other site 1121335000095 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1121335000096 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1121335000097 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1121335000098 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1121335000099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000100 Walker A/P-loop; other site 1121335000101 ATP binding site [chemical binding]; other site 1121335000102 Q-loop/lid; other site 1121335000103 ABC transporter signature motif; other site 1121335000104 Walker B; other site 1121335000105 D-loop; other site 1121335000106 H-loop/switch region; other site 1121335000107 DNA polymerase IV; Reviewed; Region: PRK03103 1121335000108 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121335000109 active site 1121335000110 DNA binding site [nucleotide binding] 1121335000111 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1121335000112 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1121335000113 homotrimer interaction site [polypeptide binding]; other site 1121335000114 putative active site [active] 1121335000115 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1121335000116 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1121335000117 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1121335000118 active site 1121335000119 FMN binding site [chemical binding]; other site 1121335000120 substrate binding site [chemical binding]; other site 1121335000121 putative catalytic residue [active] 1121335000122 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335000123 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335000124 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1121335000125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335000126 NAD(P) binding site [chemical binding]; other site 1121335000127 active site 1121335000128 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1121335000129 L-aspartate oxidase; Provisional; Region: PRK06175 1121335000130 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1121335000131 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1121335000132 Walker A/P-loop; other site 1121335000133 ATP binding site [chemical binding]; other site 1121335000134 Q-loop/lid; other site 1121335000135 ABC transporter signature motif; other site 1121335000136 Walker B; other site 1121335000137 D-loop; other site 1121335000138 H-loop/switch region; other site 1121335000139 NIL domain; Region: NIL; pfam09383 1121335000140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000141 dimer interface [polypeptide binding]; other site 1121335000142 conserved gate region; other site 1121335000143 ABC-ATPase subunit interface; other site 1121335000144 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1121335000145 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1121335000146 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335000147 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335000148 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1121335000149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335000150 DNA-binding site [nucleotide binding]; DNA binding site 1121335000151 FCD domain; Region: FCD; pfam07729 1121335000152 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121335000153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335000154 DNA-binding site [nucleotide binding]; DNA binding site 1121335000155 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1121335000156 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1121335000157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335000158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335000159 homodimer interface [polypeptide binding]; other site 1121335000160 catalytic residue [active] 1121335000161 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1121335000162 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1121335000163 peptide binding site [polypeptide binding]; other site 1121335000164 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335000165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000166 dimer interface [polypeptide binding]; other site 1121335000167 conserved gate region; other site 1121335000168 putative PBP binding loops; other site 1121335000169 ABC-ATPase subunit interface; other site 1121335000170 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121335000171 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335000172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000173 dimer interface [polypeptide binding]; other site 1121335000174 conserved gate region; other site 1121335000175 putative PBP binding loops; other site 1121335000176 ABC-ATPase subunit interface; other site 1121335000177 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335000178 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335000179 Walker A/P-loop; other site 1121335000180 ATP binding site [chemical binding]; other site 1121335000181 Q-loop/lid; other site 1121335000182 ABC transporter signature motif; other site 1121335000183 Walker B; other site 1121335000184 D-loop; other site 1121335000185 H-loop/switch region; other site 1121335000186 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335000187 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1121335000188 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335000189 Walker A/P-loop; other site 1121335000190 ATP binding site [chemical binding]; other site 1121335000191 Q-loop/lid; other site 1121335000192 ABC transporter signature motif; other site 1121335000193 Walker B; other site 1121335000194 D-loop; other site 1121335000195 H-loop/switch region; other site 1121335000196 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335000197 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1121335000198 homotrimer interaction site [polypeptide binding]; other site 1121335000199 putative active site [active] 1121335000200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121335000201 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1121335000202 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1121335000203 active site 1121335000204 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335000205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335000206 dimerization interface [polypeptide binding]; other site 1121335000207 Histidine kinase; Region: His_kinase; pfam06580 1121335000208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000209 ATP binding site [chemical binding]; other site 1121335000210 Mg2+ binding site [ion binding]; other site 1121335000211 G-X-G motif; other site 1121335000212 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335000213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000214 active site 1121335000215 phosphorylation site [posttranslational modification] 1121335000216 intermolecular recognition site; other site 1121335000217 dimerization interface [polypeptide binding]; other site 1121335000218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000220 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000222 dimer interface [polypeptide binding]; other site 1121335000223 conserved gate region; other site 1121335000224 ABC-ATPase subunit interface; other site 1121335000225 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000227 dimer interface [polypeptide binding]; other site 1121335000228 conserved gate region; other site 1121335000229 putative PBP binding loops; other site 1121335000230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335000231 ABC-ATPase subunit interface; other site 1121335000232 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000233 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121335000234 5S rRNA interface [nucleotide binding]; other site 1121335000235 CTC domain interface [polypeptide binding]; other site 1121335000236 L16 interface [polypeptide binding]; other site 1121335000237 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1121335000238 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335000239 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1121335000240 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1121335000241 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1121335000242 active site 1121335000243 Substrate binding site; other site 1121335000244 Mg++ binding site; other site 1121335000245 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121335000246 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1121335000247 ATP cone domain; Region: ATP-cone; pfam03477 1121335000248 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1121335000249 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1121335000250 active site 1121335000251 Zn binding site [ion binding]; other site 1121335000252 glycine loop; other site 1121335000253 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1121335000254 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1121335000255 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121335000256 trimer interface [polypeptide binding]; other site 1121335000257 active site 1121335000258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1121335000259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335000260 Coenzyme A binding pocket [chemical binding]; other site 1121335000261 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1121335000262 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1121335000263 O-Antigen ligase; Region: Wzy_C; pfam04932 1121335000264 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1121335000265 active site 1121335000266 dimer interfaces [polypeptide binding]; other site 1121335000267 catalytic residues [active] 1121335000268 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121335000269 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121335000270 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121335000271 nucleoside/Zn binding site; other site 1121335000272 dimer interface [polypeptide binding]; other site 1121335000273 catalytic motif [active] 1121335000274 Stage II sporulation protein; Region: SpoIID; pfam08486 1121335000275 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1121335000276 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 1121335000277 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121335000278 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121335000279 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1121335000280 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1121335000281 MreB and similar proteins; Region: MreB_like; cd10225 1121335000282 nucleotide binding site [chemical binding]; other site 1121335000283 putative protofilament interaction site [polypeptide binding]; other site 1121335000284 RodZ interaction site [polypeptide binding]; other site 1121335000285 Mg binding site [ion binding]; other site 1121335000286 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1121335000287 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121335000288 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1121335000289 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1121335000290 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121335000291 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335000292 Rod binding protein; Region: Rod-binding; cl01626 1121335000293 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335000294 S-layer homology domain; Region: SLH; pfam00395 1121335000295 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335000296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000297 Walker A/P-loop; other site 1121335000298 ATP binding site [chemical binding]; other site 1121335000299 Q-loop/lid; other site 1121335000300 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335000301 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1121335000302 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1121335000303 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335000304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335000305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000306 active site 1121335000307 phosphorylation site [posttranslational modification] 1121335000308 intermolecular recognition site; other site 1121335000309 dimerization interface [polypeptide binding]; other site 1121335000310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335000311 DNA binding site [nucleotide binding] 1121335000312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335000313 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121335000314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335000315 dimerization interface [polypeptide binding]; other site 1121335000316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335000317 dimer interface [polypeptide binding]; other site 1121335000318 phosphorylation site [posttranslational modification] 1121335000319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000320 ATP binding site [chemical binding]; other site 1121335000321 Mg2+ binding site [ion binding]; other site 1121335000322 G-X-G motif; other site 1121335000323 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1121335000324 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1121335000325 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1121335000326 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000328 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121335000329 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1121335000330 putative NAD(P) binding site [chemical binding]; other site 1121335000331 catalytic Zn binding site [ion binding]; other site 1121335000332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335000333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121335000334 active site 1121335000335 catalytic tetrad [active] 1121335000336 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1121335000337 glycogen branching enzyme; Provisional; Region: PRK05402 1121335000338 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1121335000339 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1121335000340 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1121335000341 active site 1121335000342 catalytic site [active] 1121335000343 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1121335000344 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000345 Interdomain contacts; other site 1121335000346 Cytokine receptor motif; other site 1121335000347 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000348 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000349 Interdomain contacts; other site 1121335000350 Cytokine receptor motif; other site 1121335000351 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000352 Interdomain contacts; other site 1121335000353 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000354 Interdomain contacts; other site 1121335000355 Cytokine receptor motif; other site 1121335000356 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000357 Interdomain contacts; other site 1121335000358 Cytokine receptor motif; other site 1121335000359 S-layer homology domain; Region: SLH; pfam00395 1121335000360 S-layer homology domain; Region: SLH; pfam00395 1121335000361 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 1121335000362 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1121335000363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335000364 S-adenosylmethionine binding site [chemical binding]; other site 1121335000365 Pleckstrin homology-like domain; Region: PH-like; cl17171 1121335000366 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1121335000367 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1121335000368 spore coat protein YutH; Region: spore_yutH; TIGR02905 1121335000369 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1121335000370 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1121335000371 Potassium binding sites [ion binding]; other site 1121335000372 Cesium cation binding sites [ion binding]; other site 1121335000373 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1121335000374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000376 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000378 dimer interface [polypeptide binding]; other site 1121335000379 conserved gate region; other site 1121335000380 putative PBP binding loops; other site 1121335000381 ABC-ATPase subunit interface; other site 1121335000382 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000384 dimer interface [polypeptide binding]; other site 1121335000385 conserved gate region; other site 1121335000386 ABC-ATPase subunit interface; other site 1121335000387 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1121335000388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000389 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000390 S-layer homology domain; Region: SLH; pfam00395 1121335000391 S-layer homology domain; Region: SLH; pfam00395 1121335000392 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1121335000393 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1121335000394 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1121335000395 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335000396 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1121335000397 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1121335000398 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1121335000399 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121335000400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335000401 DNA-binding site [nucleotide binding]; DNA binding site 1121335000402 FCD domain; Region: FCD; pfam07729 1121335000403 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1121335000404 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121335000405 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121335000406 dimer interface [polypeptide binding]; other site 1121335000407 ssDNA binding site [nucleotide binding]; other site 1121335000408 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121335000409 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1121335000410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335000411 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335000412 FeS/SAM binding site; other site 1121335000413 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1121335000414 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121335000415 putative NAD(P) binding site [chemical binding]; other site 1121335000416 active site 1121335000417 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121335000418 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121335000419 Ligand binding site; other site 1121335000420 Putative Catalytic site; other site 1121335000421 DXD motif; other site 1121335000422 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1121335000423 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1121335000424 FMN binding site [chemical binding]; other site 1121335000425 active site 1121335000426 catalytic residues [active] 1121335000427 substrate binding site [chemical binding]; other site 1121335000428 Bacterial Ig-like domain; Region: Big_5; pfam13205 1121335000429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1121335000430 O-Antigen ligase; Region: Wzy_C; pfam04932 1121335000431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335000432 TPR motif; other site 1121335000433 binding surface 1121335000434 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335000435 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121335000436 MULE transposase domain; Region: MULE; pfam10551 1121335000437 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1121335000438 LicD family; Region: LicD; pfam04991 1121335000439 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1121335000440 putative ADP-binding pocket [chemical binding]; other site 1121335000441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335000442 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1121335000443 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1121335000444 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335000445 MULE transposase domain; Region: MULE; pfam10551 1121335000446 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1121335000447 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121335000448 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121335000449 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1121335000450 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335000451 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1121335000452 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1121335000453 LicD family; Region: LicD; cl01378 1121335000454 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121335000455 substrate binding site; other site 1121335000456 dimer interface; other site 1121335000457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335000458 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121335000459 NAD(P) binding site [chemical binding]; other site 1121335000460 active site 1121335000461 S-layer homology domain; Region: SLH; pfam00395 1121335000462 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335000463 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335000464 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335000465 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335000466 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335000467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335000468 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335000469 binding surface 1121335000470 TPR motif; other site 1121335000471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335000472 binding surface 1121335000473 TPR motif; other site 1121335000474 TPR repeat; Region: TPR_11; pfam13414 1121335000475 Histidine kinase; Region: His_kinase; pfam06580 1121335000476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000477 ATP binding site [chemical binding]; other site 1121335000478 Mg2+ binding site [ion binding]; other site 1121335000479 G-X-G motif; other site 1121335000480 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335000481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000482 active site 1121335000483 phosphorylation site [posttranslational modification] 1121335000484 intermolecular recognition site; other site 1121335000485 dimerization interface [polypeptide binding]; other site 1121335000486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000487 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1121335000488 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121335000489 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1121335000490 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1121335000491 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1121335000492 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1121335000493 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1121335000494 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121335000495 heterodimer interface [polypeptide binding]; other site 1121335000496 homodimer interface [polypeptide binding]; other site 1121335000497 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335000498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000499 Walker A motif; other site 1121335000500 ATP binding site [chemical binding]; other site 1121335000501 Walker B motif; other site 1121335000502 arginine finger; other site 1121335000503 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1121335000504 Protein of unknown function DUF58; Region: DUF58; pfam01882 1121335000505 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000506 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000507 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000508 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000509 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335000510 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335000511 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1121335000512 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1121335000513 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121335000514 active site 1121335000515 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1121335000516 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121335000517 Active Sites [active] 1121335000518 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1121335000519 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1121335000520 CysD dimerization site [polypeptide binding]; other site 1121335000521 G1 box; other site 1121335000522 putative GEF interaction site [polypeptide binding]; other site 1121335000523 GTP/Mg2+ binding site [chemical binding]; other site 1121335000524 Switch I region; other site 1121335000525 G2 box; other site 1121335000526 G3 box; other site 1121335000527 Switch II region; other site 1121335000528 G4 box; other site 1121335000529 G5 box; other site 1121335000530 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1121335000531 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1121335000532 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1121335000533 Rrf2 family protein; Region: rrf2_super; TIGR00738 1121335000534 Transcriptional regulator; Region: Rrf2; pfam02082 1121335000535 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1121335000536 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1121335000537 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121335000538 SWIM zinc finger; Region: SWIM; pfam04434 1121335000539 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1121335000540 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1121335000541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335000542 ATP binding site [chemical binding]; other site 1121335000543 putative Mg++ binding site [ion binding]; other site 1121335000544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335000545 nucleotide binding region [chemical binding]; other site 1121335000546 ATP-binding site [chemical binding]; other site 1121335000547 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1121335000548 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121335000549 RF-1 domain; Region: RF-1; pfam00472 1121335000550 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1121335000551 Hemerythrin; Region: Hemerythrin; cd12107 1121335000552 Fe binding site [ion binding]; other site 1121335000553 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1121335000554 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1121335000555 metal binding site [ion binding]; metal-binding site 1121335000556 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335000557 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335000558 Integrase core domain; Region: rve; pfam00665 1121335000559 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335000560 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121335000561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335000562 FeS/SAM binding site; other site 1121335000563 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121335000564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335000565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335000566 putative substrate translocation pore; other site 1121335000567 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121335000568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335000569 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121335000570 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121335000571 active site residue [active] 1121335000572 ankyin-like protein; Provisional; Region: PHA02946 1121335000573 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000574 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000575 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000577 dimer interface [polypeptide binding]; other site 1121335000578 conserved gate region; other site 1121335000579 putative PBP binding loops; other site 1121335000580 ABC-ATPase subunit interface; other site 1121335000581 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335000584 ABC-ATPase subunit interface; other site 1121335000585 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1121335000586 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1121335000587 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121335000588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000589 active site 1121335000590 phosphorylation site [posttranslational modification] 1121335000591 intermolecular recognition site; other site 1121335000592 dimerization interface [polypeptide binding]; other site 1121335000593 CheB methylesterase; Region: CheB_methylest; pfam01339 1121335000594 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000596 dimer interface [polypeptide binding]; other site 1121335000597 conserved gate region; other site 1121335000598 ABC-ATPase subunit interface; other site 1121335000599 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000601 dimer interface [polypeptide binding]; other site 1121335000602 conserved gate region; other site 1121335000603 putative PBP binding loops; other site 1121335000604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335000605 ABC-ATPase subunit interface; other site 1121335000606 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000607 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000611 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335000612 PHP domain; Region: PHP; pfam02811 1121335000613 active site 1121335000614 PHP-associated; Region: PHP_C; pfam13263 1121335000615 S-layer homology domain; Region: SLH; pfam00395 1121335000616 S-layer homology domain; Region: SLH; pfam00395 1121335000617 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121335000618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000619 active site 1121335000620 phosphorylation site [posttranslational modification] 1121335000621 intermolecular recognition site; other site 1121335000622 dimerization interface [polypeptide binding]; other site 1121335000623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335000627 dimerization interface [polypeptide binding]; other site 1121335000628 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335000629 Histidine kinase; Region: His_kinase; pfam06580 1121335000630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000632 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000634 dimer interface [polypeptide binding]; other site 1121335000635 conserved gate region; other site 1121335000636 putative PBP binding loops; other site 1121335000637 ABC-ATPase subunit interface; other site 1121335000638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000640 dimer interface [polypeptide binding]; other site 1121335000641 conserved gate region; other site 1121335000642 putative PBP binding loops; other site 1121335000643 ABC-ATPase subunit interface; other site 1121335000644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000646 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000648 dimer interface [polypeptide binding]; other site 1121335000649 conserved gate region; other site 1121335000650 ABC-ATPase subunit interface; other site 1121335000651 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000653 dimer interface [polypeptide binding]; other site 1121335000654 conserved gate region; other site 1121335000655 putative PBP binding loops; other site 1121335000656 ABC-ATPase subunit interface; other site 1121335000657 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000660 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335000661 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335000662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000663 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1121335000664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000666 dimer interface [polypeptide binding]; other site 1121335000667 conserved gate region; other site 1121335000668 putative PBP binding loops; other site 1121335000669 ABC-ATPase subunit interface; other site 1121335000670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000672 dimer interface [polypeptide binding]; other site 1121335000673 conserved gate region; other site 1121335000674 putative PBP binding loops; other site 1121335000675 ABC-ATPase subunit interface; other site 1121335000676 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1121335000677 Amidohydrolase; Region: Amidohydro_2; pfam04909 1121335000678 active site 1121335000679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121335000680 active site 1121335000681 Flavin Reductases; Region: FlaRed; cl00801 1121335000682 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1121335000683 CoenzymeA binding site [chemical binding]; other site 1121335000684 subunit interaction site [polypeptide binding]; other site 1121335000685 PHB binding site; other site 1121335000686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335000687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335000688 DNA binding site [nucleotide binding] 1121335000689 domain linker motif; other site 1121335000690 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335000691 ligand binding site [chemical binding]; other site 1121335000692 dimerization interface [polypeptide binding]; other site 1121335000693 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000695 dimer interface [polypeptide binding]; other site 1121335000696 conserved gate region; other site 1121335000697 ABC-ATPase subunit interface; other site 1121335000698 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000700 dimer interface [polypeptide binding]; other site 1121335000701 ABC-ATPase subunit interface; other site 1121335000702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000704 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1121335000705 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335000706 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335000707 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335000708 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1121335000709 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1121335000710 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1121335000711 TrkA-N domain; Region: TrkA_N; pfam02254 1121335000712 TrkA-C domain; Region: TrkA_C; pfam02080 1121335000713 TrkA-N domain; Region: TrkA_N; pfam02254 1121335000714 TrkA-C domain; Region: TrkA_C; pfam02080 1121335000715 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1121335000716 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121335000717 HAMP domain; Region: HAMP; pfam00672 1121335000718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335000719 dimerization interface [polypeptide binding]; other site 1121335000720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335000721 dimer interface [polypeptide binding]; other site 1121335000722 phosphorylation site [posttranslational modification] 1121335000723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000724 ATP binding site [chemical binding]; other site 1121335000725 Mg2+ binding site [ion binding]; other site 1121335000726 G-X-G motif; other site 1121335000727 Probable beta-xylosidase; Provisional; Region: PLN03080 1121335000728 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335000729 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335000730 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335000731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000734 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1121335000735 ligand-binding site [chemical binding]; other site 1121335000736 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1121335000737 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1121335000738 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1121335000739 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 1121335000740 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121335000741 minor groove reading motif; other site 1121335000742 helix-hairpin-helix signature motif; other site 1121335000743 substrate binding pocket [chemical binding]; other site 1121335000744 active site 1121335000745 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1121335000746 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1121335000747 homodimer interface [polypeptide binding]; other site 1121335000748 metal binding site [ion binding]; metal-binding site 1121335000749 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1121335000750 homodimer interface [polypeptide binding]; other site 1121335000751 active site 1121335000752 putative chemical substrate binding site [chemical binding]; other site 1121335000753 metal binding site [ion binding]; metal-binding site 1121335000754 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335000755 RNA binding surface [nucleotide binding]; other site 1121335000756 YabP family; Region: YabP; cl06766 1121335000757 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 1121335000758 Predicted permeases [General function prediction only]; Region: COG0679 1121335000759 Septum formation initiator; Region: DivIC; pfam04977 1121335000760 serine O-acetyltransferase; Region: cysE; TIGR01172 1121335000761 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1121335000762 trimer interface [polypeptide binding]; other site 1121335000763 active site 1121335000764 substrate binding site [chemical binding]; other site 1121335000765 CoA binding site [chemical binding]; other site 1121335000766 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1121335000767 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121335000768 active site 1121335000769 HIGH motif; other site 1121335000770 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121335000771 KMSKS motif; other site 1121335000772 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1121335000773 tRNA binding surface [nucleotide binding]; other site 1121335000774 anticodon binding site; other site 1121335000775 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121335000776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335000777 dimer interface [polypeptide binding]; other site 1121335000778 putative CheW interface [polypeptide binding]; other site 1121335000779 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121335000780 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1121335000781 DXD motif; other site 1121335000782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1121335000783 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1121335000784 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 1121335000785 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1121335000786 DNA repair protein RadA; Provisional; Region: PRK11823 1121335000787 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1121335000788 Walker A motif/ATP binding site; other site 1121335000789 ATP binding site [chemical binding]; other site 1121335000790 Walker B motif; other site 1121335000791 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1121335000792 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 1121335000793 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1121335000794 putative active site [active] 1121335000795 TRAM domain; Region: TRAM; cl01282 1121335000796 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121335000797 substrate binding site; other site 1121335000798 dimer interface; other site 1121335000799 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1121335000800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335000801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335000802 homodimer interface [polypeptide binding]; other site 1121335000803 catalytic residue [active] 1121335000804 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1121335000805 elongation factor G; Reviewed; Region: PRK12740 1121335000806 G1 box; other site 1121335000807 putative GEF interaction site [polypeptide binding]; other site 1121335000808 GTP/Mg2+ binding site [chemical binding]; other site 1121335000809 Switch I region; other site 1121335000810 G2 box; other site 1121335000811 G3 box; other site 1121335000812 Switch II region; other site 1121335000813 G4 box; other site 1121335000814 G5 box; other site 1121335000815 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121335000816 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121335000817 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121335000818 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1121335000819 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1121335000820 UvrB/uvrC motif; Region: UVR; pfam02151 1121335000821 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1121335000822 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1121335000823 ADP binding site [chemical binding]; other site 1121335000824 phosphagen binding site; other site 1121335000825 substrate specificity loop; other site 1121335000826 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1121335000827 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335000828 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000830 Walker A motif; other site 1121335000831 ATP binding site [chemical binding]; other site 1121335000832 Walker B motif; other site 1121335000833 arginine finger; other site 1121335000834 UvrB/uvrC motif; Region: UVR; pfam02151 1121335000835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000836 Walker A motif; other site 1121335000837 ATP binding site [chemical binding]; other site 1121335000838 Walker B motif; other site 1121335000839 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121335000840 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1121335000841 23S rRNA interface [nucleotide binding]; other site 1121335000842 L3 interface [polypeptide binding]; other site 1121335000843 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1121335000844 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1121335000845 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121335000846 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335000847 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335000848 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121335000849 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1121335000850 Predicted membrane protein [Function unknown]; Region: COG3601 1121335000851 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1121335000852 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121335000853 Predicted membrane protein [Function unknown]; Region: COG2323 1121335000854 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121335000855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121335000856 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335000857 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121335000858 nucleotide binding site [chemical binding]; other site 1121335000859 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1121335000860 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1121335000861 dimerization interface 3.5A [polypeptide binding]; other site 1121335000862 active site 1121335000863 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1121335000864 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1121335000865 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121335000866 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121335000867 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121335000868 RPB1 interaction site [polypeptide binding]; other site 1121335000869 RPB10 interaction site [polypeptide binding]; other site 1121335000870 RPB11 interaction site [polypeptide binding]; other site 1121335000871 RPB3 interaction site [polypeptide binding]; other site 1121335000872 RPB12 interaction site [polypeptide binding]; other site 1121335000873 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1121335000874 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1121335000875 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1121335000876 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1121335000877 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1121335000878 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121335000879 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1121335000880 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1121335000881 G-loop; other site 1121335000882 DNA binding site [nucleotide binding] 1121335000883 TraX protein; Region: TraX; pfam05857 1121335000884 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121335000885 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1121335000886 putative ligand binding site [chemical binding]; other site 1121335000887 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 1121335000888 putative active site [active] 1121335000889 putative metal binding site [ion binding]; other site 1121335000890 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 1121335000891 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1121335000892 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1121335000893 homoserine dehydrogenase; Provisional; Region: PRK06349 1121335000894 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1121335000895 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1121335000896 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1121335000897 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335000898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335000899 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1121335000900 Walker A/P-loop; other site 1121335000901 ATP binding site [chemical binding]; other site 1121335000902 Q-loop/lid; other site 1121335000903 ABC transporter signature motif; other site 1121335000904 Walker B; other site 1121335000905 D-loop; other site 1121335000906 H-loop/switch region; other site 1121335000907 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335000908 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335000909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000910 Walker A/P-loop; other site 1121335000911 ATP binding site [chemical binding]; other site 1121335000912 Q-loop/lid; other site 1121335000913 ABC transporter signature motif; other site 1121335000914 Walker B; other site 1121335000915 D-loop; other site 1121335000916 H-loop/switch region; other site 1121335000917 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335000918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000920 hypothetical protein; Validated; Region: PRK00153 1121335000921 recombination protein RecR; Reviewed; Region: recR; PRK00076 1121335000922 RecR protein; Region: RecR; pfam02132 1121335000923 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1121335000924 putative active site [active] 1121335000925 putative metal-binding site [ion binding]; other site 1121335000926 tetramer interface [polypeptide binding]; other site 1121335000927 AAA domain; Region: AAA_17; pfam13207 1121335000928 AAA domain; Region: AAA_18; pfam13238 1121335000929 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335000930 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121335000931 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1121335000932 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335000933 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1121335000934 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1121335000935 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 1121335000936 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1121335000937 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1121335000938 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1121335000939 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 1121335000940 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 1121335000941 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1121335000942 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1121335000943 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121335000944 Metal-binding active site; metal-binding site 1121335000945 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1121335000946 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1121335000947 putative ligand binding site [chemical binding]; other site 1121335000948 putative NAD binding site [chemical binding]; other site 1121335000949 catalytic site [active] 1121335000950 Probable beta-xylosidase; Provisional; Region: PLN03080 1121335000951 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335000952 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335000953 LysE type translocator; Region: LysE; pfam01810 1121335000954 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1121335000955 active site 1121335000956 tetramer interface; other site 1121335000957 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1121335000958 Maf-like protein; Region: Maf; pfam02545 1121335000959 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1121335000960 active site 1121335000961 dimer interface [polypeptide binding]; other site 1121335000962 rod shape-determining protein MreB; Provisional; Region: PRK13927 1121335000963 MreB and similar proteins; Region: MreB_like; cd10225 1121335000964 nucleotide binding site [chemical binding]; other site 1121335000965 Mg binding site [ion binding]; other site 1121335000966 putative protofilament interaction site [polypeptide binding]; other site 1121335000967 RodZ interaction site [polypeptide binding]; other site 1121335000968 rod shape-determining protein MreC; Provisional; Region: PRK13922 1121335000969 rod shape-determining protein MreC; Region: MreC; pfam04085 1121335000970 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1121335000971 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1121335000972 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121335000973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121335000974 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1121335000975 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1121335000976 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1121335000977 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1121335000978 Switch I; other site 1121335000979 Switch II; other site 1121335000980 cell division topological specificity factor MinE; Provisional; Region: PRK13987 1121335000981 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1121335000982 substrate binding site [chemical binding]; other site 1121335000983 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335000984 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335000985 metal binding site [ion binding]; metal-binding site 1121335000986 active site 1121335000987 I-site; other site 1121335000988 V-type ATP synthase subunit I; Validated; Region: PRK05771 1121335000989 V-type ATP synthase subunit K; Validated; Region: PRK06558 1121335000990 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1121335000991 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1121335000992 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 1121335000993 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 1121335000994 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 1121335000995 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 1121335000996 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 1121335000997 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1121335000998 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335000999 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1121335001000 Walker A motif/ATP binding site; other site 1121335001001 Walker B motif; other site 1121335001002 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335001003 V-type ATP synthase subunit B; Provisional; Region: PRK04196 1121335001004 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335001005 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1121335001006 Walker A motif homologous position; other site 1121335001007 Walker B motif; other site 1121335001008 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335001009 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 1121335001010 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1121335001011 peptidase T; Region: peptidase-T; TIGR01882 1121335001012 metal binding site [ion binding]; metal-binding site 1121335001013 dimer interface [polypeptide binding]; other site 1121335001014 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1121335001015 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335001016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335001017 motif II; other site 1121335001018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001019 Walker A/P-loop; other site 1121335001020 ATP binding site [chemical binding]; other site 1121335001021 Q-loop/lid; other site 1121335001022 transglutaminase; Provisional; Region: tgl; PRK03187 1121335001023 YtxC-like family; Region: YtxC; pfam08812 1121335001024 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1121335001025 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121335001026 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1121335001027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001028 Walker A/P-loop; other site 1121335001029 ATP binding site [chemical binding]; other site 1121335001030 Q-loop/lid; other site 1121335001031 ABC transporter signature motif; other site 1121335001032 Walker B; other site 1121335001033 D-loop; other site 1121335001034 H-loop/switch region; other site 1121335001035 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121335001036 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1121335001037 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1121335001038 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121335001039 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1121335001040 C-terminal peptidase (prc); Region: prc; TIGR00225 1121335001041 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1121335001042 protein binding site [polypeptide binding]; other site 1121335001043 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1121335001044 Catalytic dyad [active] 1121335001045 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1121335001046 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335001047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335001048 S-adenosylmethionine binding site [chemical binding]; other site 1121335001049 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1121335001050 DNA replication protein DnaC; Validated; Region: PRK06835 1121335001051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335001052 Walker A motif; other site 1121335001053 ATP binding site [chemical binding]; other site 1121335001054 Walker B motif; other site 1121335001055 arginine finger; other site 1121335001056 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1121335001057 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1121335001058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001059 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1121335001060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001061 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335001062 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1121335001063 active site 1121335001064 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335001065 Interdomain contacts; other site 1121335001066 Cytokine receptor motif; other site 1121335001067 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121335001068 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121335001069 hinge; other site 1121335001070 active site 1121335001071 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335001072 Zn2+ binding site [ion binding]; other site 1121335001073 Mg2+ binding site [ion binding]; other site 1121335001074 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1121335001075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335001076 Walker A motif; other site 1121335001077 ATP binding site [chemical binding]; other site 1121335001078 Walker B motif; other site 1121335001079 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121335001080 anti sigma factor interaction site; other site 1121335001081 regulatory phosphorylation site [posttranslational modification]; other site 1121335001082 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1121335001083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335001084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335001085 DNA binding site [nucleotide binding] 1121335001086 domain linker motif; other site 1121335001087 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335001088 dimerization interface [polypeptide binding]; other site 1121335001089 ligand binding site [chemical binding]; other site 1121335001090 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1121335001091 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 1121335001092 catalytic domain interface [polypeptide binding]; other site 1121335001093 homodimer interface [polypeptide binding]; other site 1121335001094 putative active site [active] 1121335001095 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335001096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335001097 MULE transposase domain; Region: MULE; pfam10551 1121335001098 integron integrase; Region: integrase_gron; TIGR02249 1121335001099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335001100 active site 1121335001101 DNA binding site [nucleotide binding] 1121335001102 Int/Topo IB signature motif; other site 1121335001103 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121335001104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335001105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335001106 non-specific DNA binding site [nucleotide binding]; other site 1121335001107 salt bridge; other site 1121335001108 sequence-specific DNA binding site [nucleotide binding]; other site 1121335001109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335001110 non-specific DNA binding site [nucleotide binding]; other site 1121335001111 salt bridge; other site 1121335001112 sequence-specific DNA binding site [nucleotide binding]; other site 1121335001113 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1121335001114 RecT family; Region: RecT; cl04285 1121335001115 Helix-turn-helix domain; Region: HTH_36; pfam13730 1121335001116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1121335001117 Walker A motif; other site 1121335001118 ATP binding site [chemical binding]; other site 1121335001119 Walker B motif; other site 1121335001120 arginine finger; other site 1121335001121 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1121335001122 putative active site [active] 1121335001123 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 1121335001124 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1121335001125 Terminase small subunit; Region: Terminase_2; pfam03592 1121335001126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335001127 MULE transposase domain; Region: MULE; pfam10551 1121335001128 Phage terminase large subunit; Region: Terminase_3; cl12054 1121335001129 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1121335001130 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1121335001131 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1121335001132 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1121335001133 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1121335001134 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1121335001135 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1121335001136 Phage XkdN-like protein; Region: XkdN; pfam08890 1121335001137 Phage-related minor tail protein [Function unknown]; Region: COG5281 1121335001138 tape measure domain; Region: tape_meas_nterm; TIGR02675 1121335001139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001140 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1121335001141 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1121335001142 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1121335001143 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1121335001144 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1121335001145 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1121335001146 amidase catalytic site [active] 1121335001147 Zn binding residues [ion binding]; other site 1121335001148 substrate binding site [chemical binding]; other site 1121335001149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335001150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335001151 non-specific DNA binding site [nucleotide binding]; other site 1121335001152 salt bridge; other site 1121335001153 sequence-specific DNA binding site [nucleotide binding]; other site 1121335001154 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121335001155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335001156 DNA binding site [nucleotide binding] 1121335001157 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1121335001158 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1121335001159 AAA domain; Region: AAA_21; pfam13304 1121335001160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001161 Walker B; other site 1121335001162 D-loop; other site 1121335001163 H-loop/switch region; other site 1121335001164 Transmembrane protein; Region: Macoilin; pfam09726 1121335001165 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1121335001166 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001167 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121335001168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335001169 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335001171 S-adenosylmethionine binding site [chemical binding]; other site 1121335001172 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121335001173 catalytic core [active] 1121335001174 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1121335001175 Melibiase; Region: Melibiase; pfam02065 1121335001176 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1121335001177 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1121335001178 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121335001179 S-adenosylmethionine binding site [chemical binding]; other site 1121335001180 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121335001181 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121335001182 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121335001183 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1121335001184 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1121335001185 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1121335001186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335001187 ATP binding site [chemical binding]; other site 1121335001188 putative Mg++ binding site [ion binding]; other site 1121335001189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1121335001190 nucleotide binding region [chemical binding]; other site 1121335001191 ATP-binding site [chemical binding]; other site 1121335001192 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335001193 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1121335001194 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1121335001195 dimerization interface [polypeptide binding]; other site 1121335001196 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335001197 Histidine kinase; Region: His_kinase; pfam06580 1121335001198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001199 ATP binding site [chemical binding]; other site 1121335001200 Mg2+ binding site [ion binding]; other site 1121335001201 G-X-G motif; other site 1121335001202 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335001203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001204 active site 1121335001205 phosphorylation site [posttranslational modification] 1121335001206 intermolecular recognition site; other site 1121335001207 dimerization interface [polypeptide binding]; other site 1121335001208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001209 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1121335001210 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001211 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121335001212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335001213 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001214 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001216 dimer interface [polypeptide binding]; other site 1121335001217 conserved gate region; other site 1121335001218 ABC-ATPase subunit interface; other site 1121335001219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001221 ABC-ATPase subunit interface; other site 1121335001222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335001224 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1121335001225 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335001226 HSP70 interaction site [polypeptide binding]; other site 1121335001227 mannonate dehydratase; Provisional; Region: PRK03906 1121335001228 mannonate dehydratase; Region: uxuA; TIGR00695 1121335001229 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121335001230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001231 FeS/SAM binding site; other site 1121335001232 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121335001233 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1121335001234 putative ADP-ribose binding site [chemical binding]; other site 1121335001235 putative active site [active] 1121335001236 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335001237 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335001238 DNA binding site [nucleotide binding] 1121335001239 domain linker motif; other site 1121335001240 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335001241 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001243 dimer interface [polypeptide binding]; other site 1121335001244 conserved gate region; other site 1121335001245 putative PBP binding loops; other site 1121335001246 ABC-ATPase subunit interface; other site 1121335001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001248 dimer interface [polypeptide binding]; other site 1121335001249 conserved gate region; other site 1121335001250 putative PBP binding loops; other site 1121335001251 ABC-ATPase subunit interface; other site 1121335001252 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001253 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335001254 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001256 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1121335001257 active site 1121335001258 catalytic triad [active] 1121335001259 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1121335001260 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1121335001261 Substrate binding site [chemical binding]; other site 1121335001262 Leucine rich repeat; Region: LRR_8; pfam13855 1121335001263 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1121335001264 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1121335001265 S-layer homology domain; Region: SLH; pfam00395 1121335001266 S-layer homology domain; Region: SLH; pfam00395 1121335001267 S-layer homology domain; Region: SLH; pfam00395 1121335001268 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121335001269 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121335001270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335001271 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121335001272 active site 1121335001273 catalytic tetrad [active] 1121335001274 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335001275 active site 1121335001276 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121335001277 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1121335001278 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121335001279 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335001280 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335001281 Walker A/P-loop; other site 1121335001282 ATP binding site [chemical binding]; other site 1121335001283 Q-loop/lid; other site 1121335001284 ABC transporter signature motif; other site 1121335001285 Walker B; other site 1121335001286 D-loop; other site 1121335001287 H-loop/switch region; other site 1121335001288 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335001289 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335001290 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335001291 Walker A/P-loop; other site 1121335001292 ATP binding site [chemical binding]; other site 1121335001293 Q-loop/lid; other site 1121335001294 ABC transporter signature motif; other site 1121335001295 Walker B; other site 1121335001296 D-loop; other site 1121335001297 H-loop/switch region; other site 1121335001298 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335001299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335001300 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335001301 TM-ABC transporter signature motif; other site 1121335001302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335001303 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335001304 TM-ABC transporter signature motif; other site 1121335001305 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1121335001306 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1121335001307 ligand binding site [chemical binding]; other site 1121335001308 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335001309 CoA binding domain; Region: CoA_binding_2; pfam13380 1121335001310 SurA N-terminal domain; Region: SurA_N_3; cl07813 1121335001311 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1121335001312 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1121335001313 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1121335001314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335001315 dimerization interface [polypeptide binding]; other site 1121335001316 Histidine kinase; Region: His_kinase; pfam06580 1121335001317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001318 Mg2+ binding site [ion binding]; other site 1121335001319 G-X-G motif; other site 1121335001320 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335001321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001322 active site 1121335001323 phosphorylation site [posttranslational modification] 1121335001324 intermolecular recognition site; other site 1121335001325 dimerization interface [polypeptide binding]; other site 1121335001326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335001327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001329 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001331 dimer interface [polypeptide binding]; other site 1121335001332 conserved gate region; other site 1121335001333 ABC-ATPase subunit interface; other site 1121335001334 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001336 dimer interface [polypeptide binding]; other site 1121335001337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335001338 ABC-ATPase subunit interface; other site 1121335001339 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335001340 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1121335001341 active site 1121335001342 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1121335001343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001344 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335001345 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335001346 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121335001347 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121335001348 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121335001349 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1121335001350 catalytic site [active] 1121335001351 FlxA-like protein; Region: FlxA; pfam14282 1121335001352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001353 RPEL repeat; Region: RPEL; cl15286 1121335001354 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001356 dimer interface [polypeptide binding]; other site 1121335001357 conserved gate region; other site 1121335001358 putative PBP binding loops; other site 1121335001359 ABC-ATPase subunit interface; other site 1121335001360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001362 dimer interface [polypeptide binding]; other site 1121335001363 conserved gate region; other site 1121335001364 putative PBP binding loops; other site 1121335001365 ABC-ATPase subunit interface; other site 1121335001366 Bacterial Ig-like domain; Region: Big_5; pfam13205 1121335001367 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1121335001368 MG2 domain; Region: A2M_N; pfam01835 1121335001369 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1121335001370 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1121335001371 homodimer interface [polypeptide binding]; other site 1121335001372 substrate-cofactor binding pocket; other site 1121335001373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335001374 catalytic residue [active] 1121335001375 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1121335001376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001377 FeS/SAM binding site; other site 1121335001378 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1121335001379 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1121335001380 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1121335001381 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1121335001382 homodimer interface [polypeptide binding]; other site 1121335001383 oligonucleotide binding site [chemical binding]; other site 1121335001384 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121335001385 metal binding site 2 [ion binding]; metal-binding site 1121335001386 putative DNA binding helix; other site 1121335001387 metal binding site 1 [ion binding]; metal-binding site 1121335001388 dimer interface [polypeptide binding]; other site 1121335001389 structural Zn2+ binding site [ion binding]; other site 1121335001390 peroxiredoxin; Region: AhpC; TIGR03137 1121335001391 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1121335001392 dimer interface [polypeptide binding]; other site 1121335001393 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1121335001394 catalytic triad [active] 1121335001395 peroxidatic and resolving cysteines [active] 1121335001396 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1121335001397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335001398 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1121335001399 catalytic residue [active] 1121335001400 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1121335001401 catalytic residues [active] 1121335001402 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1121335001403 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1121335001404 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1121335001405 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1121335001406 GTP1/OBG; Region: GTP1_OBG; pfam01018 1121335001407 Obg GTPase; Region: Obg; cd01898 1121335001408 G1 box; other site 1121335001409 GTP/Mg2+ binding site [chemical binding]; other site 1121335001410 Switch I region; other site 1121335001411 G2 box; other site 1121335001412 G3 box; other site 1121335001413 Switch II region; other site 1121335001414 G4 box; other site 1121335001415 G5 box; other site 1121335001416 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1121335001417 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1121335001418 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1121335001419 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1121335001420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001421 active site 1121335001422 phosphorylation site [posttranslational modification] 1121335001423 intermolecular recognition site; other site 1121335001424 LytTr DNA-binding domain; Region: LytTR; smart00850 1121335001425 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1121335001426 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1121335001427 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1121335001428 Trp docking motif [polypeptide binding]; other site 1121335001429 AP endonuclease family 2; Region: AP2Ec; smart00518 1121335001430 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121335001431 Metal-binding active site; metal-binding site 1121335001432 AP (apurinic/apyrimidinic) site pocket; other site 1121335001433 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1121335001434 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1121335001435 FAD binding pocket [chemical binding]; other site 1121335001436 FAD binding motif [chemical binding]; other site 1121335001437 phosphate binding motif [ion binding]; other site 1121335001438 beta-alpha-beta structure motif; other site 1121335001439 NAD binding pocket [chemical binding]; other site 1121335001440 Iron coordination center [ion binding]; other site 1121335001441 putative oxidoreductase; Provisional; Region: PRK12831 1121335001442 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335001443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335001444 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1121335001445 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1121335001446 trimer interface [polypeptide binding]; other site 1121335001447 active site 1121335001448 dimer interface [polypeptide binding]; other site 1121335001449 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121335001450 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121335001451 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121335001452 active site 1121335001453 elongation factor P; Validated; Region: PRK00529 1121335001454 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1121335001455 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1121335001456 RNA binding site [nucleotide binding]; other site 1121335001457 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1121335001458 RNA binding site [nucleotide binding]; other site 1121335001459 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1121335001460 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121335001461 Walker A motif; other site 1121335001462 ATP binding site [chemical binding]; other site 1121335001463 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1121335001464 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1121335001465 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1121335001466 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1121335001467 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1121335001468 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1121335001469 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1121335001470 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1121335001471 germination protease; Provisional; Region: PRK12362 1121335001472 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335001473 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335001474 active site 1121335001475 metal binding site [ion binding]; metal-binding site 1121335001476 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1121335001477 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1121335001478 nucleotide binding pocket [chemical binding]; other site 1121335001479 K-X-D-G motif; other site 1121335001480 catalytic site [active] 1121335001481 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1121335001482 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1121335001483 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1121335001484 Dimer interface [polypeptide binding]; other site 1121335001485 BRCT sequence motif; other site 1121335001486 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1121335001487 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1121335001488 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1121335001489 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1121335001490 NodB motif; other site 1121335001491 active site 1121335001492 catalytic site [active] 1121335001493 Cd binding site [ion binding]; other site 1121335001494 YabP family; Region: YabP; cl06766 1121335001495 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1121335001496 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1121335001497 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1121335001498 PhoH-like protein; Region: PhoH; pfam02562 1121335001499 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1121335001500 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1121335001501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335001502 Zn2+ binding site [ion binding]; other site 1121335001503 Mg2+ binding site [ion binding]; other site 1121335001504 metal-binding heat shock protein; Provisional; Region: PRK00016 1121335001505 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1121335001506 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1121335001507 Peptidase family M50; Region: Peptidase_M50; pfam02163 1121335001508 active site 1121335001509 putative substrate binding region [chemical binding]; other site 1121335001510 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1121335001511 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1121335001512 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1121335001513 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1121335001514 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1121335001515 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1121335001516 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1121335001517 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335001518 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1121335001519 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1121335001520 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1121335001521 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1121335001522 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1121335001523 FliG C-terminal domain; Region: FliG_C; pfam01706 1121335001524 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121335001525 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1121335001526 Flagellar assembly protein FliH; Region: FliH; pfam02108 1121335001527 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 1121335001528 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335001529 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1121335001530 Walker A motif/ATP binding site; other site 1121335001531 Walker B motif; other site 1121335001532 MgtE intracellular N domain; Region: MgtE_N; smart00924 1121335001533 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1121335001534 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1121335001535 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1121335001536 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 1121335001537 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1121335001538 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121335001539 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1121335001540 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335001541 Flagellar protein (FlbD); Region: FlbD; pfam06289 1121335001542 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1121335001543 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1121335001544 flagellar motor switch protein; Validated; Region: PRK08119 1121335001545 CheC-like family; Region: CheC; pfam04509 1121335001546 CheC-like family; Region: CheC; pfam04509 1121335001547 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1121335001548 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335001549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001550 active site 1121335001551 phosphorylation site [posttranslational modification] 1121335001552 intermolecular recognition site; other site 1121335001553 dimerization interface [polypeptide binding]; other site 1121335001554 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1121335001555 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1121335001556 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1121335001557 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1121335001558 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1121335001559 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1121335001560 B12 binding domain; Region: B12-binding; pfam02310 1121335001561 B12 binding site [chemical binding]; other site 1121335001562 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1121335001563 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 1121335001564 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1121335001565 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1121335001566 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335001567 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335001568 Walker A/P-loop; other site 1121335001569 ATP binding site [chemical binding]; other site 1121335001570 Q-loop/lid; other site 1121335001571 ABC transporter signature motif; other site 1121335001572 Walker B; other site 1121335001573 D-loop; other site 1121335001574 H-loop/switch region; other site 1121335001575 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335001576 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1121335001577 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335001578 active site 1121335001579 HIGH motif; other site 1121335001580 nucleotide binding site [chemical binding]; other site 1121335001581 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121335001582 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121335001583 active site 1121335001584 KMSKS motif; other site 1121335001585 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1121335001586 tRNA binding surface [nucleotide binding]; other site 1121335001587 anticodon binding site; other site 1121335001588 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121335001589 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1121335001590 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1121335001591 oligomer interface [polypeptide binding]; other site 1121335001592 active site 1121335001593 metal binding site [ion binding]; metal-binding site 1121335001594 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1121335001595 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1121335001596 oligomer interface [polypeptide binding]; other site 1121335001597 active site 1121335001598 metal binding site [ion binding]; metal-binding site 1121335001599 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1121335001600 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1121335001601 oligomer interface [polypeptide binding]; other site 1121335001602 active site 1121335001603 metal binding site [ion binding]; metal-binding site 1121335001604 Carbohydrate binding domain; Region: CBM_25; smart01066 1121335001605 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 1121335001606 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1121335001607 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1121335001608 catalytic residues [active] 1121335001609 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1121335001610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001611 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001613 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1121335001614 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121335001615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335001616 dimerization interface [polypeptide binding]; other site 1121335001617 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335001618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335001619 dimer interface [polypeptide binding]; other site 1121335001620 putative CheW interface [polypeptide binding]; other site 1121335001621 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121335001622 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121335001623 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1121335001624 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1121335001625 Predicted transcriptional regulator [Transcription]; Region: COG4189 1121335001626 Helix-turn-helix domain; Region: HTH_20; pfam12840 1121335001627 dimerization interface [polypeptide binding]; other site 1121335001628 putative DNA binding site [nucleotide binding]; other site 1121335001629 putative Zn2+ binding site [ion binding]; other site 1121335001630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001631 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1121335001632 dimer interface [polypeptide binding]; other site 1121335001633 active site 1121335001634 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1121335001635 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1121335001636 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1121335001637 Spore germination protein; Region: Spore_permease; cl17796 1121335001638 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1121335001639 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335001640 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335001641 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335001642 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1121335001643 glycogen synthase; Provisional; Region: glgA; PRK00654 1121335001644 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1121335001645 ADP-binding pocket [chemical binding]; other site 1121335001646 homodimer interface [polypeptide binding]; other site 1121335001647 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121335001648 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1121335001649 dimer interface [polypeptide binding]; other site 1121335001650 active site 1121335001651 metal binding site [ion binding]; metal-binding site 1121335001652 glutathione binding site [chemical binding]; other site 1121335001653 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1121335001654 Part of AAA domain; Region: AAA_19; pfam13245 1121335001655 Family description; Region: UvrD_C_2; pfam13538 1121335001656 Oligomerisation domain; Region: Oligomerisation; pfam02410 1121335001657 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1121335001658 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1121335001659 HIGH motif; other site 1121335001660 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121335001661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335001662 active site 1121335001663 KMSKS motif; other site 1121335001664 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1121335001665 tRNA binding surface [nucleotide binding]; other site 1121335001666 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1121335001667 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1121335001668 active site 1121335001669 dimer interface [polypeptide binding]; other site 1121335001670 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121335001671 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121335001672 acyl-activating enzyme (AAE) consensus motif; other site 1121335001673 putative active site [active] 1121335001674 putative AMP binding site [chemical binding]; other site 1121335001675 putative CoA binding site [chemical binding]; other site 1121335001676 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1121335001677 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1121335001678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001679 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 1121335001680 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1121335001681 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1121335001682 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 1121335001683 DRTGG domain; Region: DRTGG; pfam07085 1121335001684 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121335001685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001686 ATP binding site [chemical binding]; other site 1121335001687 Mg2+ binding site [ion binding]; other site 1121335001688 G-X-G motif; other site 1121335001689 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335001690 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335001691 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335001692 Putative Fe-S cluster; Region: FeS; cl17515 1121335001693 DRTGG domain; Region: DRTGG; pfam07085 1121335001694 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335001695 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1121335001696 active site 1121335001697 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335001698 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1121335001699 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1121335001700 FAD binding pocket [chemical binding]; other site 1121335001701 FAD binding motif [chemical binding]; other site 1121335001702 phosphate binding motif [ion binding]; other site 1121335001703 beta-alpha-beta structure motif; other site 1121335001704 NAD binding pocket [chemical binding]; other site 1121335001705 Iron coordination center [ion binding]; other site 1121335001706 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1121335001707 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1121335001708 heterodimer interface [polypeptide binding]; other site 1121335001709 active site 1121335001710 FMN binding site [chemical binding]; other site 1121335001711 homodimer interface [polypeptide binding]; other site 1121335001712 substrate binding site [chemical binding]; other site 1121335001713 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121335001714 catalytic core [active] 1121335001715 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335001716 active site 1121335001717 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1121335001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335001719 S-adenosylmethionine binding site [chemical binding]; other site 1121335001720 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1121335001721 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1121335001722 lipoyl synthase; Provisional; Region: PRK05481 1121335001723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001724 FeS/SAM binding site; other site 1121335001725 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335001726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001727 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001729 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 1121335001730 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1121335001731 L-rhamnose isomerase; Provisional; Region: PRK01076 1121335001732 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1121335001733 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1121335001734 Isochorismatase family; Region: Isochorismatase; pfam00857 1121335001735 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1121335001736 catalytic triad [active] 1121335001737 conserved cis-peptide bond; other site 1121335001738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001739 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335001740 active site 1121335001741 phosphorylation site [posttranslational modification] 1121335001742 intermolecular recognition site; other site 1121335001743 dimerization interface [polypeptide binding]; other site 1121335001744 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335001747 dimerization interface [polypeptide binding]; other site 1121335001748 Histidine kinase; Region: His_kinase; pfam06580 1121335001749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001750 ATP binding site [chemical binding]; other site 1121335001751 Mg2+ binding site [ion binding]; other site 1121335001752 G-X-G motif; other site 1121335001753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001754 active site 1121335001755 phosphorylation site [posttranslational modification] 1121335001756 intermolecular recognition site; other site 1121335001757 dimerization interface [polypeptide binding]; other site 1121335001758 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335001759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001761 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335001762 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001764 dimer interface [polypeptide binding]; other site 1121335001765 conserved gate region; other site 1121335001766 putative PBP binding loops; other site 1121335001767 ABC-ATPase subunit interface; other site 1121335001768 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001770 dimer interface [polypeptide binding]; other site 1121335001771 conserved gate region; other site 1121335001772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335001773 ABC-ATPase subunit interface; other site 1121335001774 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1121335001775 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1121335001776 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 1121335001777 Ca binding site [ion binding]; other site 1121335001778 carbohydrate binding site [chemical binding]; other site 1121335001779 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1121335001780 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121335001781 dimer interface [polypeptide binding]; other site 1121335001782 motif 1; other site 1121335001783 active site 1121335001784 motif 2; other site 1121335001785 motif 3; other site 1121335001786 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1121335001787 anticodon binding site; other site 1121335001788 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121335001789 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121335001790 dimer interface [polypeptide binding]; other site 1121335001791 anticodon binding site; other site 1121335001792 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121335001793 homodimer interface [polypeptide binding]; other site 1121335001794 motif 1; other site 1121335001795 active site 1121335001796 motif 2; other site 1121335001797 GAD domain; Region: GAD; pfam02938 1121335001798 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121335001799 motif 3; other site 1121335001800 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121335001801 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121335001802 Catalytic site [active] 1121335001803 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1121335001804 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1121335001805 generic binding surface II; other site 1121335001806 generic binding surface I; other site 1121335001807 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1121335001808 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1121335001809 active site 1121335001810 putative PHP Thumb interface [polypeptide binding]; other site 1121335001811 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1121335001812 Trp repressor protein; Region: Trp_repressor; cl17266 1121335001813 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1121335001814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335001815 ATP binding site [chemical binding]; other site 1121335001816 putative Mg++ binding site [ion binding]; other site 1121335001817 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1121335001818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1121335001819 nucleotide binding region [chemical binding]; other site 1121335001820 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1121335001821 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335001822 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335001823 6-phosphofructokinase; Provisional; Region: PRK14072 1121335001824 active site 1121335001825 ADP/pyrophosphate binding site [chemical binding]; other site 1121335001826 dimerization interface [polypeptide binding]; other site 1121335001827 allosteric effector site; other site 1121335001828 fructose-1,6-bisphosphate binding site; other site 1121335001829 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1121335001830 putative metal binding site [ion binding]; other site 1121335001831 Integral membrane protein DUF95; Region: DUF95; pfam01944 1121335001832 RDD family; Region: RDD; pfam06271 1121335001833 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1121335001834 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335001835 dimer interface [polypeptide binding]; other site 1121335001836 PYR/PP interface [polypeptide binding]; other site 1121335001837 TPP binding site [chemical binding]; other site 1121335001838 substrate binding site [chemical binding]; other site 1121335001839 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121335001840 Domain of unknown function; Region: EKR; pfam10371 1121335001841 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1121335001842 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1121335001843 TPP-binding site [chemical binding]; other site 1121335001844 dimer interface [polypeptide binding]; other site 1121335001845 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1121335001846 active site 1121335001847 putative catalytic site [active] 1121335001848 DNA binding site [nucleotide binding] 1121335001849 putative phosphate binding site [ion binding]; other site 1121335001850 metal binding site A [ion binding]; metal-binding site 1121335001851 AP binding site [nucleotide binding]; other site 1121335001852 metal binding site B [ion binding]; metal-binding site 1121335001853 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1121335001854 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1121335001855 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335001856 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1121335001857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335001858 motif II; other site 1121335001859 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1121335001860 KWG Leptospira; Region: KWG; pfam07656 1121335001861 Holin family; Region: Phage_holin_4; pfam05105 1121335001862 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1121335001863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335001864 DNA binding residues [nucleotide binding] 1121335001865 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335001866 PQQ-like domain; Region: PQQ_2; pfam13360 1121335001867 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1121335001868 Trp docking motif [polypeptide binding]; other site 1121335001869 active site 1121335001870 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1121335001871 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121335001872 transmembrane helices; other site 1121335001873 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1121335001874 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1121335001875 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1121335001876 dimer interface [polypeptide binding]; other site 1121335001877 active site 1121335001878 metal binding site [ion binding]; metal-binding site 1121335001879 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 1121335001880 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 1121335001881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001882 FeS/SAM binding site; other site 1121335001883 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1121335001884 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 1121335001885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001886 FeS/SAM binding site; other site 1121335001887 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1121335001888 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1121335001889 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1121335001890 G1 box; other site 1121335001891 GTP/Mg2+ binding site [chemical binding]; other site 1121335001892 Switch I region; other site 1121335001893 G2 box; other site 1121335001894 Switch II region; other site 1121335001895 G3 box; other site 1121335001896 G4 box; other site 1121335001897 G5 box; other site 1121335001898 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001900 dimer interface [polypeptide binding]; other site 1121335001901 conserved gate region; other site 1121335001902 putative PBP binding loops; other site 1121335001903 ABC-ATPase subunit interface; other site 1121335001904 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335001905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335001906 TPR motif; other site 1121335001907 binding surface 1121335001908 Yip1 domain; Region: Yip1; pfam04893 1121335001909 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1121335001910 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335001911 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1121335001912 active site 1121335001913 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1121335001914 substrate binding site [chemical binding]; other site 1121335001915 active site 1121335001916 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335001917 metal binding site [ion binding]; metal-binding site 1121335001918 ligand binding site [chemical binding]; other site 1121335001919 Rhomboid family; Region: Rhomboid; cl11446 1121335001920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335001921 dimerization interface [polypeptide binding]; other site 1121335001922 putative DNA binding site [nucleotide binding]; other site 1121335001923 putative Zn2+ binding site [ion binding]; other site 1121335001924 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121335001925 Heavy-metal-associated domain; Region: HMA; pfam00403 1121335001926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335001927 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335001928 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1121335001929 FHIPEP family; Region: FHIPEP; pfam00771 1121335001930 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1121335001931 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335001932 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1121335001933 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335001934 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121335001935 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1121335001936 PilZ domain; Region: PilZ; pfam07238 1121335001937 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121335001938 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121335001939 putative binding surface; other site 1121335001940 active site 1121335001941 P2 response regulator binding domain; Region: P2; pfam07194 1121335001942 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121335001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001944 ATP binding site [chemical binding]; other site 1121335001945 Mg2+ binding site [ion binding]; other site 1121335001946 G-X-G motif; other site 1121335001947 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121335001948 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121335001949 putative CheA interaction surface; other site 1121335001950 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1121335001951 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121335001952 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1121335001953 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 1121335001954 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335001955 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335001956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335001957 DNA binding residues [nucleotide binding] 1121335001958 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121335001959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335001960 Zn2+ binding site [ion binding]; other site 1121335001961 Mg2+ binding site [ion binding]; other site 1121335001962 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1121335001963 dihydropteroate synthase; Region: DHPS; TIGR01496 1121335001964 substrate binding pocket [chemical binding]; other site 1121335001965 dimer interface [polypeptide binding]; other site 1121335001966 inhibitor binding site; inhibition site 1121335001967 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1121335001968 homooctamer interface [polypeptide binding]; other site 1121335001969 active site 1121335001970 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1121335001971 catalytic center binding site [active] 1121335001972 ATP binding site [chemical binding]; other site 1121335001973 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1121335001974 GTP cyclohydrolase I; Provisional; Region: PLN03044 1121335001975 active site 1121335001976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335001977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335001978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001979 Walker A/P-loop; other site 1121335001980 ATP binding site [chemical binding]; other site 1121335001981 Q-loop/lid; other site 1121335001982 ABC transporter signature motif; other site 1121335001983 Walker B; other site 1121335001984 D-loop; other site 1121335001985 H-loop/switch region; other site 1121335001986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335001987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335001988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001989 Walker A/P-loop; other site 1121335001990 ATP binding site [chemical binding]; other site 1121335001991 Q-loop/lid; other site 1121335001992 ABC transporter signature motif; other site 1121335001993 Walker B; other site 1121335001994 D-loop; other site 1121335001995 H-loop/switch region; other site 1121335001996 Chromate transporter; Region: Chromate_transp; pfam02417 1121335001997 Chromate transporter; Region: Chromate_transp; pfam02417 1121335001998 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1121335001999 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335002000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335002001 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1121335002002 SmpB-tmRNA interface; other site 1121335002003 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1121335002004 amidase catalytic site [active] 1121335002005 Zn binding residues [ion binding]; other site 1121335002006 substrate binding site [chemical binding]; other site 1121335002007 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1121335002008 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1121335002009 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1121335002010 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121335002011 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1121335002012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335002013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002014 dimer interface [polypeptide binding]; other site 1121335002015 conserved gate region; other site 1121335002016 putative PBP binding loops; other site 1121335002017 ABC-ATPase subunit interface; other site 1121335002018 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335002019 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121335002020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002021 dimer interface [polypeptide binding]; other site 1121335002022 conserved gate region; other site 1121335002023 putative PBP binding loops; other site 1121335002024 ABC-ATPase subunit interface; other site 1121335002025 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335002026 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002027 Walker A/P-loop; other site 1121335002028 ATP binding site [chemical binding]; other site 1121335002029 Q-loop/lid; other site 1121335002030 ABC transporter signature motif; other site 1121335002031 Walker B; other site 1121335002032 D-loop; other site 1121335002033 H-loop/switch region; other site 1121335002034 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121335002035 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121335002036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002037 Walker A/P-loop; other site 1121335002038 ATP binding site [chemical binding]; other site 1121335002039 Q-loop/lid; other site 1121335002040 ABC transporter signature motif; other site 1121335002041 Walker B; other site 1121335002042 D-loop; other site 1121335002043 H-loop/switch region; other site 1121335002044 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335002045 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121335002046 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121335002047 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121335002048 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1121335002049 active site 1121335002050 PAS fold; Region: PAS_4; pfam08448 1121335002051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335002052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002053 dimer interface [polypeptide binding]; other site 1121335002054 phosphorylation site [posttranslational modification] 1121335002055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002056 ATP binding site [chemical binding]; other site 1121335002057 Mg2+ binding site [ion binding]; other site 1121335002058 G-X-G motif; other site 1121335002059 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1121335002060 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121335002061 putative active site [active] 1121335002062 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 1121335002063 Predicted transcriptional regulator [Transcription]; Region: COG3432 1121335002064 aconitate hydratase; Validated; Region: PRK07229 1121335002065 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 1121335002066 substrate binding site [chemical binding]; other site 1121335002067 ligand binding site [chemical binding]; other site 1121335002068 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 1121335002069 substrate binding site [chemical binding]; other site 1121335002070 isocitrate dehydrogenase; Validated; Region: PRK08299 1121335002071 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121335002072 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335002073 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1121335002074 pseudouridine synthase; Region: TIGR00093 1121335002075 active site 1121335002076 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1121335002077 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1121335002078 dimer interface [polypeptide binding]; other site 1121335002079 active site 1121335002080 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1121335002081 folate binding site [chemical binding]; other site 1121335002082 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1121335002083 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1121335002084 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1121335002085 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1121335002086 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1121335002087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121335002088 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335002089 Predicted membrane protein [Function unknown]; Region: COG1971 1121335002090 Domain of unknown function DUF; Region: DUF204; pfam02659 1121335002091 Domain of unknown function DUF; Region: DUF204; pfam02659 1121335002092 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1121335002093 ApbE family; Region: ApbE; pfam02424 1121335002094 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1121335002095 trimer interface [polypeptide binding]; other site 1121335002096 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 1121335002097 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1121335002098 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1121335002099 Y-family of DNA polymerases; Region: PolY; cl12025 1121335002100 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1121335002101 ssDNA binding site; other site 1121335002102 generic binding surface II; other site 1121335002103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335002104 ATP binding site [chemical binding]; other site 1121335002105 putative Mg++ binding site [ion binding]; other site 1121335002106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335002107 nucleotide binding region [chemical binding]; other site 1121335002108 ATP-binding site [chemical binding]; other site 1121335002109 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1121335002110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335002111 S-adenosylmethionine binding site [chemical binding]; other site 1121335002112 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1121335002113 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1121335002114 active site 1121335002115 (T/H)XGH motif; other site 1121335002116 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1121335002117 Nucleoside recognition; Region: Gate; pfam07670 1121335002118 Asp23 family; Region: Asp23; pfam03780 1121335002119 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335002120 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1121335002121 HSP70 interaction site [polypeptide binding]; other site 1121335002122 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335002123 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335002124 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335002125 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335002126 active site 1121335002127 metal binding site [ion binding]; metal-binding site 1121335002128 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1121335002129 MutS domain III; Region: MutS_III; pfam05192 1121335002130 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1121335002131 Walker A/P-loop; other site 1121335002132 ATP binding site [chemical binding]; other site 1121335002133 Q-loop/lid; other site 1121335002134 ABC transporter signature motif; other site 1121335002135 Walker B; other site 1121335002136 D-loop; other site 1121335002137 H-loop/switch region; other site 1121335002138 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121335002139 Smr domain; Region: Smr; pfam01713 1121335002140 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 1121335002141 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335002142 dimer interface [polypeptide binding]; other site 1121335002143 PYR/PP interface [polypeptide binding]; other site 1121335002144 TPP binding site [chemical binding]; other site 1121335002145 substrate binding site [chemical binding]; other site 1121335002146 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1121335002147 TPP-binding site; other site 1121335002148 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1121335002149 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1121335002150 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121335002151 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1121335002152 acyl-activating enzyme (AAE) consensus motif; other site 1121335002153 AMP binding site [chemical binding]; other site 1121335002154 active site 1121335002155 CoA binding site [chemical binding]; other site 1121335002156 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1121335002157 Family of unknown function (DUF633); Region: DUF633; pfam04816 1121335002158 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121335002159 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121335002160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1121335002161 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121335002162 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121335002163 Predicted transcriptional regulators [Transcription]; Region: COG1725 1121335002164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335002165 DNA-binding site [nucleotide binding]; DNA binding site 1121335002166 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121335002167 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335002168 Walker A/P-loop; other site 1121335002169 ATP binding site [chemical binding]; other site 1121335002170 Q-loop/lid; other site 1121335002171 ABC transporter signature motif; other site 1121335002172 Walker B; other site 1121335002173 D-loop; other site 1121335002174 H-loop/switch region; other site 1121335002175 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1121335002176 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1121335002177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1121335002178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335002179 Coenzyme A binding pocket [chemical binding]; other site 1121335002180 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1121335002181 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1121335002182 active site 1121335002183 homodimer interface [polypeptide binding]; other site 1121335002184 Helix-hairpin-helix motif; Region: HHH; pfam00633 1121335002185 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1121335002186 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1121335002187 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1121335002188 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121335002189 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121335002190 active site 1121335002191 dimer interface [polypeptide binding]; other site 1121335002192 motif 1; other site 1121335002193 motif 2; other site 1121335002194 motif 3; other site 1121335002195 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121335002196 anticodon binding site; other site 1121335002197 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 1121335002198 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1121335002199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335002200 active site 1121335002201 motif I; other site 1121335002202 motif II; other site 1121335002203 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1121335002204 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1121335002205 DJ-1 family protein; Region: not_thiJ; TIGR01383 1121335002206 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1121335002207 conserved cys residue [active] 1121335002208 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1121335002209 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121335002210 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121335002211 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1121335002212 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1121335002213 active site 1121335002214 intersubunit interface [polypeptide binding]; other site 1121335002215 catalytic residue [active] 1121335002216 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121335002217 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1121335002218 substrate binding site [chemical binding]; other site 1121335002219 ATP binding site [chemical binding]; other site 1121335002220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335002221 MULE transposase domain; Region: MULE; pfam10551 1121335002222 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121335002223 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335002224 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1121335002225 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121335002226 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335002227 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335002228 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121335002229 IMP binding site; other site 1121335002230 dimer interface [polypeptide binding]; other site 1121335002231 interdomain contacts; other site 1121335002232 partial ornithine binding site; other site 1121335002233 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121335002234 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002235 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002236 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1121335002237 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1121335002238 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1121335002239 catalytic site [active] 1121335002240 subunit interface [polypeptide binding]; other site 1121335002241 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1121335002242 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1121335002243 active site 1121335002244 tetramer interface [polypeptide binding]; other site 1121335002245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335002246 active site 1121335002247 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1121335002248 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1121335002249 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1121335002250 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121335002251 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121335002252 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1121335002253 putative active site [active] 1121335002254 putative metal binding residues [ion binding]; other site 1121335002255 signature motif; other site 1121335002256 putative dimer interface [polypeptide binding]; other site 1121335002257 putative phosphate binding site [ion binding]; other site 1121335002258 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335002259 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002261 dimer interface [polypeptide binding]; other site 1121335002262 conserved gate region; other site 1121335002263 putative PBP binding loops; other site 1121335002264 ABC-ATPase subunit interface; other site 1121335002265 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002267 dimer interface [polypeptide binding]; other site 1121335002268 conserved gate region; other site 1121335002269 ABC-ATPase subunit interface; other site 1121335002270 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121335002271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335002272 DNA-binding site [nucleotide binding]; DNA binding site 1121335002273 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002274 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335002275 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1121335002276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121335002277 CAAX protease self-immunity; Region: Abi; pfam02517 1121335002278 S-layer homology domain; Region: SLH; pfam00395 1121335002279 S-layer homology domain; Region: SLH; pfam00395 1121335002280 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121335002281 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121335002282 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121335002283 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1121335002284 putative active site [active] 1121335002285 putative metal binding site [ion binding]; other site 1121335002286 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335002287 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002289 ABC-ATPase subunit interface; other site 1121335002290 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002292 dimer interface [polypeptide binding]; other site 1121335002293 conserved gate region; other site 1121335002294 putative PBP binding loops; other site 1121335002295 ABC-ATPase subunit interface; other site 1121335002296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002297 HAMP domain; Region: HAMP; pfam00672 1121335002298 Histidine kinase; Region: His_kinase; pfam06580 1121335002299 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1121335002300 ATP binding site [chemical binding]; other site 1121335002301 Mg2+ binding site [ion binding]; other site 1121335002302 G-X-G motif; other site 1121335002303 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335002304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002305 active site 1121335002306 phosphorylation site [posttranslational modification] 1121335002307 intermolecular recognition site; other site 1121335002308 dimerization interface [polypeptide binding]; other site 1121335002309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002310 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002311 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002312 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1121335002313 active site 1121335002314 catalytic residues [active] 1121335002315 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1121335002316 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1121335002317 NAD(P) binding site [chemical binding]; other site 1121335002318 LDH/MDH dimer interface [polypeptide binding]; other site 1121335002319 substrate binding site [chemical binding]; other site 1121335002320 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335002321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002324 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1121335002325 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1121335002326 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1121335002327 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121335002328 Domain of unknown function DUF77; Region: DUF77; pfam01910 1121335002329 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002331 dimer interface [polypeptide binding]; other site 1121335002332 conserved gate region; other site 1121335002333 putative PBP binding loops; other site 1121335002334 ABC-ATPase subunit interface; other site 1121335002335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121335002336 NMT1/THI5 like; Region: NMT1; pfam09084 1121335002337 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335002338 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335002339 Walker A/P-loop; other site 1121335002340 ATP binding site [chemical binding]; other site 1121335002341 Q-loop/lid; other site 1121335002342 ABC transporter signature motif; other site 1121335002343 Walker B; other site 1121335002344 D-loop; other site 1121335002345 H-loop/switch region; other site 1121335002346 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1121335002347 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121335002348 DNA binding residues [nucleotide binding] 1121335002349 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1121335002350 Ferredoxin [Energy production and conversion]; Region: COG1146 1121335002351 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335002352 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121335002353 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1121335002354 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121335002355 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1121335002356 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121335002357 putative NAD(P) binding site [chemical binding]; other site 1121335002358 catalytic Zn binding site [ion binding]; other site 1121335002359 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1121335002360 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121335002361 E3 interaction surface; other site 1121335002362 lipoyl attachment site [posttranslational modification]; other site 1121335002363 e3 binding domain; Region: E3_binding; pfam02817 1121335002364 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1121335002365 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1121335002366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335002367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335002368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335002369 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121335002370 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1121335002371 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1121335002372 tetramer interface [polypeptide binding]; other site 1121335002373 TPP-binding site [chemical binding]; other site 1121335002374 heterodimer interface [polypeptide binding]; other site 1121335002375 phosphorylation loop region [posttranslational modification] 1121335002376 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1121335002377 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1121335002378 PYR/PP interface [polypeptide binding]; other site 1121335002379 dimer interface [polypeptide binding]; other site 1121335002380 TPP binding site [chemical binding]; other site 1121335002381 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335002382 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1121335002383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335002384 NAD(P) binding site [chemical binding]; other site 1121335002385 active site 1121335002386 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1121335002387 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1121335002388 active site 1121335002389 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1121335002390 N- and C-terminal domain interface [polypeptide binding]; other site 1121335002391 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1121335002392 active site 1121335002393 putative catalytic site [active] 1121335002394 metal binding site [ion binding]; metal-binding site 1121335002395 ATP binding site [chemical binding]; other site 1121335002396 carbohydrate binding site [chemical binding]; other site 1121335002397 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1121335002398 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121335002399 NlpC/P60 family; Region: NLPC_P60; cl17555 1121335002400 Restriction endonuclease; Region: Mrr_cat; pfam04471 1121335002401 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335002402 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335002403 Walker A/P-loop; other site 1121335002404 ATP binding site [chemical binding]; other site 1121335002405 Q-loop/lid; other site 1121335002406 ABC transporter signature motif; other site 1121335002407 Walker B; other site 1121335002408 D-loop; other site 1121335002409 H-loop/switch region; other site 1121335002410 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 1121335002411 CARDB; Region: CARDB; pfam07705 1121335002412 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335002413 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121335002414 FtsX-like permease family; Region: FtsX; pfam02687 1121335002415 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121335002416 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335002417 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335002418 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121335002419 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 1121335002420 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121335002421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335002422 FeS/SAM binding site; other site 1121335002423 TRAM domain; Region: TRAM; pfam01938 1121335002424 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1121335002425 MutS domain I; Region: MutS_I; pfam01624 1121335002426 MutS domain II; Region: MutS_II; pfam05188 1121335002427 MutS domain III; Region: MutS_III; pfam05192 1121335002428 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1121335002429 Walker A/P-loop; other site 1121335002430 ATP binding site [chemical binding]; other site 1121335002431 Q-loop/lid; other site 1121335002432 ABC transporter signature motif; other site 1121335002433 Walker B; other site 1121335002434 D-loop; other site 1121335002435 H-loop/switch region; other site 1121335002436 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1121335002437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002438 ATP binding site [chemical binding]; other site 1121335002439 Mg2+ binding site [ion binding]; other site 1121335002440 G-X-G motif; other site 1121335002441 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1121335002442 ATP binding site [chemical binding]; other site 1121335002443 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1121335002444 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1121335002445 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1121335002446 bacterial Hfq-like; Region: Hfq; cd01716 1121335002447 hexamer interface [polypeptide binding]; other site 1121335002448 Sm1 motif; other site 1121335002449 RNA binding site [nucleotide binding]; other site 1121335002450 Sm2 motif; other site 1121335002451 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002452 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335002453 DNA binding site [nucleotide binding] 1121335002454 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335002455 ligand binding site [chemical binding]; other site 1121335002456 dimerization interface [polypeptide binding]; other site 1121335002457 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1121335002458 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1121335002459 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1121335002460 NADP binding site [chemical binding]; other site 1121335002461 homodimer interface [polypeptide binding]; other site 1121335002462 active site 1121335002463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002465 dimer interface [polypeptide binding]; other site 1121335002466 conserved gate region; other site 1121335002467 ABC-ATPase subunit interface; other site 1121335002468 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002470 dimer interface [polypeptide binding]; other site 1121335002471 conserved gate region; other site 1121335002472 ABC-ATPase subunit interface; other site 1121335002473 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335002474 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 1121335002475 substrate binding site [chemical binding]; other site 1121335002476 active site 1121335002477 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335002478 ligand binding site [chemical binding]; other site 1121335002479 metal binding site [ion binding]; metal-binding site 1121335002480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335002482 DNA binding site [nucleotide binding] 1121335002483 domain linker motif; other site 1121335002484 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335002485 dimerization interface [polypeptide binding]; other site 1121335002486 ligand binding site [chemical binding]; other site 1121335002487 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121335002488 Carboxylesterase family; Region: COesterase; pfam00135 1121335002489 substrate binding pocket [chemical binding]; other site 1121335002490 catalytic triad [active] 1121335002491 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1121335002492 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1121335002493 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335002494 Double zinc ribbon; Region: DZR; pfam12773 1121335002495 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1121335002496 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335002497 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1121335002498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002499 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002501 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335002502 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1121335002503 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121335002504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335002505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002506 dimer interface [polypeptide binding]; other site 1121335002507 conserved gate region; other site 1121335002508 putative PBP binding loops; other site 1121335002509 ABC-ATPase subunit interface; other site 1121335002510 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335002511 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1121335002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002513 dimer interface [polypeptide binding]; other site 1121335002514 conserved gate region; other site 1121335002515 putative PBP binding loops; other site 1121335002516 ABC-ATPase subunit interface; other site 1121335002517 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335002518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002519 Walker A/P-loop; other site 1121335002520 ATP binding site [chemical binding]; other site 1121335002521 Q-loop/lid; other site 1121335002522 ABC transporter signature motif; other site 1121335002523 Walker B; other site 1121335002524 D-loop; other site 1121335002525 H-loop/switch region; other site 1121335002526 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335002527 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121335002528 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002529 Walker A/P-loop; other site 1121335002530 ATP binding site [chemical binding]; other site 1121335002531 Q-loop/lid; other site 1121335002532 ABC transporter signature motif; other site 1121335002533 Walker B; other site 1121335002534 D-loop; other site 1121335002535 H-loop/switch region; other site 1121335002536 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335002537 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1121335002538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335002539 motif I; other site 1121335002540 active site 1121335002541 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1121335002542 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121335002543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002544 active site 1121335002545 phosphorylation site [posttranslational modification] 1121335002546 intermolecular recognition site; other site 1121335002547 dimerization interface [polypeptide binding]; other site 1121335002548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335002549 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121335002550 putative active site [active] 1121335002551 heme pocket [chemical binding]; other site 1121335002552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335002553 putative active site [active] 1121335002554 heme pocket [chemical binding]; other site 1121335002555 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335002556 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121335002557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335002558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335002559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335002560 Walker A/P-loop; other site 1121335002561 ATP binding site [chemical binding]; other site 1121335002562 Q-loop/lid; other site 1121335002563 ABC transporter signature motif; other site 1121335002564 Walker B; other site 1121335002565 D-loop; other site 1121335002566 H-loop/switch region; other site 1121335002567 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335002568 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335002569 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335002570 Walker A/P-loop; other site 1121335002571 ATP binding site [chemical binding]; other site 1121335002572 Q-loop/lid; other site 1121335002573 ABC transporter signature motif; other site 1121335002574 Walker B; other site 1121335002575 D-loop; other site 1121335002576 H-loop/switch region; other site 1121335002577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335002578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002579 active site 1121335002580 phosphorylation site [posttranslational modification] 1121335002581 intermolecular recognition site; other site 1121335002582 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335002583 DNA binding site [nucleotide binding] 1121335002584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335002586 dimer interface [polypeptide binding]; other site 1121335002587 phosphorylation site [posttranslational modification] 1121335002588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002589 ATP binding site [chemical binding]; other site 1121335002590 Mg2+ binding site [ion binding]; other site 1121335002591 G-X-G motif; other site 1121335002592 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121335002593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335002594 Walker A/P-loop; other site 1121335002595 ATP binding site [chemical binding]; other site 1121335002596 Q-loop/lid; other site 1121335002597 ABC transporter signature motif; other site 1121335002598 Walker B; other site 1121335002599 D-loop; other site 1121335002600 H-loop/switch region; other site 1121335002601 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1121335002602 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335002603 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1121335002604 N- and C-terminal domain interface [polypeptide binding]; other site 1121335002605 D-xylulose kinase; Region: XylB; TIGR01312 1121335002606 active site 1121335002607 MgATP binding site [chemical binding]; other site 1121335002608 catalytic site [active] 1121335002609 metal binding site [ion binding]; metal-binding site 1121335002610 xylulose binding site [chemical binding]; other site 1121335002611 homodimer interface [polypeptide binding]; other site 1121335002612 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1121335002613 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121335002614 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335002615 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121335002616 nucleotide binding site [chemical binding]; other site 1121335002617 xylose isomerase; Provisional; Region: PRK05474 1121335002618 xylose isomerase; Region: xylose_isom_A; TIGR02630 1121335002619 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1121335002620 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121335002621 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121335002622 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121335002623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335002624 catalytic residue [active] 1121335002625 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1121335002626 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1121335002627 trimerization site [polypeptide binding]; other site 1121335002628 active site 1121335002629 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1121335002630 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121335002631 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121335002632 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1121335002633 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1121335002634 Ligand Binding Site [chemical binding]; other site 1121335002635 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1121335002636 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121335002637 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1121335002638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335002639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335002640 DNA binding residues [nucleotide binding] 1121335002641 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1121335002642 intersubunit interface [polypeptide binding]; other site 1121335002643 active site 1121335002644 catalytic residue [active] 1121335002645 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335002646 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1121335002647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1121335002648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335002649 Coenzyme A binding pocket [chemical binding]; other site 1121335002650 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1121335002651 putative homodimer interface [polypeptide binding]; other site 1121335002652 putative active site pocket [active] 1121335002653 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121335002654 DivIVA protein; Region: DivIVA; pfam05103 1121335002655 Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; Region: ACE1-Sec16-like; cl14807 1121335002656 homodimer interface [polypeptide binding]; other site 1121335002657 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1121335002658 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1121335002659 AsnC family; Region: AsnC_trans_reg; pfam01037 1121335002660 hypothetical protein; Validated; Region: PRK07682 1121335002661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335002662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002663 homodimer interface [polypeptide binding]; other site 1121335002664 catalytic residue [active] 1121335002665 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1121335002666 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1121335002667 NAD binding site [chemical binding]; other site 1121335002668 homotetramer interface [polypeptide binding]; other site 1121335002669 homodimer interface [polypeptide binding]; other site 1121335002670 substrate binding site [chemical binding]; other site 1121335002671 active site 1121335002672 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1121335002673 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335002674 Walker A/P-loop; other site 1121335002675 ATP binding site [chemical binding]; other site 1121335002676 Q-loop/lid; other site 1121335002677 ABC transporter signature motif; other site 1121335002678 Walker B; other site 1121335002679 D-loop; other site 1121335002680 H-loop/switch region; other site 1121335002681 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1121335002682 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1121335002683 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1121335002684 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1121335002685 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1121335002686 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1121335002687 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1121335002688 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1121335002689 putative dimer interface [polypeptide binding]; other site 1121335002690 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002693 ATP binding site [chemical binding]; other site 1121335002694 Mg2+ binding site [ion binding]; other site 1121335002695 G-X-G motif; other site 1121335002696 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335002697 dimer interface [polypeptide binding]; other site 1121335002698 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002699 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335002700 dimer interface [polypeptide binding]; other site 1121335002701 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002702 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1121335002703 SLBB domain; Region: SLBB; pfam10531 1121335002704 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1121335002705 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335002706 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335002707 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335002708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121335002709 catalytic loop [active] 1121335002710 iron binding site [ion binding]; other site 1121335002711 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1121335002712 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1121335002713 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335002714 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335002715 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1121335002716 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1121335002717 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121335002718 5S rRNA interface [nucleotide binding]; other site 1121335002719 CTC domain interface [polypeptide binding]; other site 1121335002720 L16 interface [polypeptide binding]; other site 1121335002721 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1121335002722 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121335002723 Metal-binding active site; metal-binding site 1121335002724 AP (apurinic/apyrimidinic) site pocket; other site 1121335002725 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335002726 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1121335002727 active site 1121335002728 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1121335002729 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1121335002730 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1121335002731 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1121335002732 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121335002733 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121335002734 metal-binding site [ion binding] 1121335002735 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121335002736 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121335002737 metal-binding site [ion binding] 1121335002738 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335002739 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121335002740 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121335002741 metal-binding site [ion binding] 1121335002742 Predicted permeases [General function prediction only]; Region: COG0679 1121335002743 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1121335002744 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1121335002745 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1121335002746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335002747 DNA-binding site [nucleotide binding]; DNA binding site 1121335002748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335002749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002750 homodimer interface [polypeptide binding]; other site 1121335002751 catalytic residue [active] 1121335002752 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1121335002753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335002754 FeS/SAM binding site; other site 1121335002755 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1121335002756 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1121335002757 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1121335002758 putative dimer interface [polypeptide binding]; other site 1121335002759 putative anticodon binding site; other site 1121335002760 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1121335002761 homodimer interface [polypeptide binding]; other site 1121335002762 motif 1; other site 1121335002763 motif 2; other site 1121335002764 active site 1121335002765 motif 3; other site 1121335002766 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121335002767 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002768 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002769 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 1121335002770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335002771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002772 homodimer interface [polypeptide binding]; other site 1121335002773 catalytic residue [active] 1121335002774 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1121335002775 catalytic triad [active] 1121335002776 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1121335002777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335002778 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1121335002779 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1121335002780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335002781 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335002782 DNA binding residues [nucleotide binding] 1121335002783 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1121335002784 DNA polymerase I; Provisional; Region: PRK05755 1121335002785 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1121335002786 active site 1121335002787 metal binding site 1 [ion binding]; metal-binding site 1121335002788 putative 5' ssDNA interaction site; other site 1121335002789 metal binding site 3; metal-binding site 1121335002790 metal binding site 2 [ion binding]; metal-binding site 1121335002791 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1121335002792 putative DNA binding site [nucleotide binding]; other site 1121335002793 putative metal binding site [ion binding]; other site 1121335002794 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1121335002795 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1121335002796 active site 1121335002797 DNA binding site [nucleotide binding] 1121335002798 catalytic site [active] 1121335002799 dephospho-CoA kinase; Region: TIGR00152 1121335002800 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1121335002801 CoA-binding site [chemical binding]; other site 1121335002802 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121335002803 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121335002804 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121335002805 catalytic residue [active] 1121335002806 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1121335002807 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1121335002808 intersubunit interface [polypeptide binding]; other site 1121335002809 active site 1121335002810 zinc binding site [ion binding]; other site 1121335002811 Na+ binding site [ion binding]; other site 1121335002812 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1121335002813 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335002814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002815 active site 1121335002816 phosphorylation site [posttranslational modification] 1121335002817 intermolecular recognition site; other site 1121335002818 dimerization interface [polypeptide binding]; other site 1121335002819 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335002820 DNA binding site [nucleotide binding] 1121335002821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335002823 dimer interface [polypeptide binding]; other site 1121335002824 phosphorylation site [posttranslational modification] 1121335002825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002826 ATP binding site [chemical binding]; other site 1121335002827 Mg2+ binding site [ion binding]; other site 1121335002828 G-X-G motif; other site 1121335002829 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335002831 DNA binding site [nucleotide binding] 1121335002832 domain linker motif; other site 1121335002833 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335002834 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335002835 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335002836 Integrase core domain; Region: rve; pfam00665 1121335002837 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1121335002838 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335002839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002840 dimer interface [polypeptide binding]; other site 1121335002841 conserved gate region; other site 1121335002842 ABC-ATPase subunit interface; other site 1121335002843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002845 dimer interface [polypeptide binding]; other site 1121335002846 conserved gate region; other site 1121335002847 putative PBP binding loops; other site 1121335002848 ABC-ATPase subunit interface; other site 1121335002849 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1121335002850 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121335002851 active site 1121335002852 catalytic site [active] 1121335002853 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121335002854 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121335002855 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1121335002856 homodimer interface [polypeptide binding]; other site 1121335002857 maltodextrin glucosidase; Provisional; Region: PRK10785 1121335002858 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1121335002859 active site 1121335002860 homodimer interface [polypeptide binding]; other site 1121335002861 catalytic site [active] 1121335002862 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121335002863 active site 1121335002864 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121335002865 active site 2 [active] 1121335002866 active site 1 [active] 1121335002867 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1121335002868 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335002869 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335002870 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335002871 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1121335002872 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1121335002873 metal binding site [ion binding]; metal-binding site 1121335002874 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1121335002875 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1121335002876 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1121335002877 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1121335002878 lipoyl attachment site [posttranslational modification]; other site 1121335002879 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1121335002880 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1121335002881 tetramer interface [polypeptide binding]; other site 1121335002882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002883 catalytic residue [active] 1121335002884 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1121335002885 tetramer interface [polypeptide binding]; other site 1121335002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002887 catalytic residue [active] 1121335002888 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1121335002889 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121335002890 dinuclear metal binding motif [ion binding]; other site 1121335002891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121335002892 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1121335002893 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1121335002894 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1121335002895 NAD(P) binding site [chemical binding]; other site 1121335002896 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121335002897 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121335002898 putative dimer interface [polypeptide binding]; other site 1121335002899 uracil-xanthine permease; Region: ncs2; TIGR00801 1121335002900 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121335002901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335002902 substrate binding pocket [chemical binding]; other site 1121335002903 membrane-bound complex binding site; other site 1121335002904 hinge residues; other site 1121335002905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002906 dimer interface [polypeptide binding]; other site 1121335002907 conserved gate region; other site 1121335002908 putative PBP binding loops; other site 1121335002909 ABC-ATPase subunit interface; other site 1121335002910 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121335002911 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121335002912 Walker A/P-loop; other site 1121335002913 ATP binding site [chemical binding]; other site 1121335002914 Q-loop/lid; other site 1121335002915 ABC transporter signature motif; other site 1121335002916 Walker B; other site 1121335002917 D-loop; other site 1121335002918 H-loop/switch region; other site 1121335002919 FOG: CBS domain [General function prediction only]; Region: COG0517 1121335002920 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1121335002921 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121335002922 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121335002923 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121335002924 Walker A/P-loop; other site 1121335002925 ATP binding site [chemical binding]; other site 1121335002926 Q-loop/lid; other site 1121335002927 ABC transporter signature motif; other site 1121335002928 Walker B; other site 1121335002929 D-loop; other site 1121335002930 H-loop/switch region; other site 1121335002931 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121335002932 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121335002933 Walker A/P-loop; other site 1121335002934 ATP binding site [chemical binding]; other site 1121335002935 Q-loop/lid; other site 1121335002936 ABC transporter signature motif; other site 1121335002937 Walker B; other site 1121335002938 D-loop; other site 1121335002939 H-loop/switch region; other site 1121335002940 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121335002941 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121335002942 TM-ABC transporter signature motif; other site 1121335002943 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335002944 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121335002945 TM-ABC transporter signature motif; other site 1121335002946 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121335002947 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1121335002948 putative ligand binding site [chemical binding]; other site 1121335002949 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1121335002950 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1121335002951 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1121335002952 Double zinc ribbon; Region: DZR; pfam12773 1121335002953 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1121335002954 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1121335002955 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1121335002956 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1121335002957 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1121335002958 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002959 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1121335002960 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1121335002961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121335002962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121335002963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121335002964 dimerization interface [polypeptide binding]; other site 1121335002965 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1121335002966 active site 1121335002967 substrate-binding site [chemical binding]; other site 1121335002968 metal-binding site [ion binding] 1121335002969 GTP binding site [chemical binding]; other site 1121335002970 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002972 dimer interface [polypeptide binding]; other site 1121335002973 conserved gate region; other site 1121335002974 ABC-ATPase subunit interface; other site 1121335002975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002977 dimer interface [polypeptide binding]; other site 1121335002978 conserved gate region; other site 1121335002979 ABC-ATPase subunit interface; other site 1121335002980 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121335002981 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002983 zinc transporter ZupT; Provisional; Region: PRK04201 1121335002984 ZIP Zinc transporter; Region: Zip; pfam02535 1121335002985 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1121335002986 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335002987 active site 1121335002988 catalytic tetrad [active] 1121335002989 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335002990 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1121335002991 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1121335002992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121335002993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121335002994 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121335002995 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121335002996 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121335002997 Protein export membrane protein; Region: SecD_SecF; cl14618 1121335002998 Protein export membrane protein; Region: SecD_SecF; cl14618 1121335002999 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335003000 PrcB C-terminal; Region: PrcB_C; pfam14343 1121335003001 PrcB C-terminal; Region: PrcB_C; pfam14343 1121335003002 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335003005 Walker A/P-loop; other site 1121335003006 ATP binding site [chemical binding]; other site 1121335003007 Q-loop/lid; other site 1121335003008 ABC transporter signature motif; other site 1121335003009 Walker B; other site 1121335003010 D-loop; other site 1121335003011 H-loop/switch region; other site 1121335003012 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003013 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003014 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335003015 Walker A/P-loop; other site 1121335003016 ATP binding site [chemical binding]; other site 1121335003017 Q-loop/lid; other site 1121335003018 ABC transporter signature motif; other site 1121335003019 Walker B; other site 1121335003020 D-loop; other site 1121335003021 H-loop/switch region; other site 1121335003022 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1121335003023 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1121335003024 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1121335003025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335003026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335003027 DNA binding site [nucleotide binding] 1121335003028 domain linker motif; other site 1121335003029 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335003030 dimerization interface [polypeptide binding]; other site 1121335003031 ligand binding site [chemical binding]; other site 1121335003032 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121335003033 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121335003034 NAD(P) binding site [chemical binding]; other site 1121335003035 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1121335003036 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1121335003037 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1121335003038 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335003039 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335003040 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121335003041 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1121335003042 active site 1121335003043 catalytic site [active] 1121335003044 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1121335003045 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1121335003046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003047 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335003048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003049 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003051 dimer interface [polypeptide binding]; other site 1121335003052 conserved gate region; other site 1121335003053 ABC-ATPase subunit interface; other site 1121335003054 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003056 dimer interface [polypeptide binding]; other site 1121335003057 ABC-ATPase subunit interface; other site 1121335003058 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003059 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335003060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335003061 sugar efflux transporter; Region: 2A0120; TIGR00899 1121335003062 putative substrate translocation pore; other site 1121335003063 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121335003064 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335003065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003066 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335003067 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1121335003068 active site 1121335003069 catalytic triad [active] 1121335003070 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335003071 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1121335003072 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1121335003073 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1121335003074 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1121335003075 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 1121335003076 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003078 dimer interface [polypeptide binding]; other site 1121335003079 conserved gate region; other site 1121335003080 putative PBP binding loops; other site 1121335003081 ABC-ATPase subunit interface; other site 1121335003082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003084 dimer interface [polypeptide binding]; other site 1121335003085 ABC-ATPase subunit interface; other site 1121335003086 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 1121335003087 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1121335003088 transketolase; Reviewed; Region: PRK05899 1121335003089 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121335003090 TPP-binding site [chemical binding]; other site 1121335003091 dimer interface [polypeptide binding]; other site 1121335003092 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1121335003093 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121335003094 PYR/PP interface [polypeptide binding]; other site 1121335003095 dimer interface [polypeptide binding]; other site 1121335003096 TPP binding site [chemical binding]; other site 1121335003097 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335003098 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1121335003099 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003100 nucleotide binding site [chemical binding]; other site 1121335003101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003102 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 1121335003103 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1121335003104 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121335003105 substrate binding site [chemical binding]; other site 1121335003106 trimer interface [polypeptide binding]; other site 1121335003107 Mn binding site [ion binding]; other site 1121335003108 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1121335003109 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1121335003110 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1121335003111 Trehalase; Region: Trehalase; cl17346 1121335003112 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335003113 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335003114 DNA binding site [nucleotide binding] 1121335003115 domain linker motif; other site 1121335003116 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335003117 ligand binding site [chemical binding]; other site 1121335003118 dimerization interface [polypeptide binding]; other site 1121335003119 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1121335003120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335003121 DEAD_2; Region: DEAD_2; pfam06733 1121335003122 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1121335003123 Probable zinc-binding domain; Region: zf-trcl; pfam13451 1121335003124 hybrid cluster protein; Provisional; Region: PRK05290 1121335003125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335003126 CODH interaction site; other site 1121335003127 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1121335003128 hybrid metal cluster; other site 1121335003129 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121335003130 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121335003131 ligand binding site [chemical binding]; other site 1121335003132 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1121335003133 putative switch regulator; other site 1121335003134 non-specific DNA interactions [nucleotide binding]; other site 1121335003135 DNA binding site [nucleotide binding] 1121335003136 sequence specific DNA binding site [nucleotide binding]; other site 1121335003137 putative cAMP binding site [chemical binding]; other site 1121335003138 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121335003139 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121335003140 acyl-activating enzyme (AAE) consensus motif; other site 1121335003141 putative active site [active] 1121335003142 putative AMP binding site [chemical binding]; other site 1121335003143 putative CoA binding site [chemical binding]; other site 1121335003144 GTP-binding protein YchF; Reviewed; Region: PRK09601 1121335003145 YchF GTPase; Region: YchF; cd01900 1121335003146 G1 box; other site 1121335003147 GTP/Mg2+ binding site [chemical binding]; other site 1121335003148 Switch I region; other site 1121335003149 G2 box; other site 1121335003150 Switch II region; other site 1121335003151 G3 box; other site 1121335003152 G4 box; other site 1121335003153 G5 box; other site 1121335003154 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1121335003155 PQQ-like domain; Region: PQQ_2; pfam13360 1121335003156 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1121335003157 YWTD domain; Region: YWTD; cl17223 1121335003158 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1121335003159 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1121335003160 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1121335003161 dimer interface [polypeptide binding]; other site 1121335003162 motif 1; other site 1121335003163 active site 1121335003164 motif 2; other site 1121335003165 motif 3; other site 1121335003166 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1121335003167 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1121335003168 putative tRNA-binding site [nucleotide binding]; other site 1121335003169 B3/4 domain; Region: B3_4; pfam03483 1121335003170 tRNA synthetase B5 domain; Region: B5; smart00874 1121335003171 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1121335003172 dimer interface [polypeptide binding]; other site 1121335003173 motif 1; other site 1121335003174 motif 3; other site 1121335003175 motif 2; other site 1121335003176 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1121335003177 hypothetical protein; Provisional; Region: PRK13670 1121335003178 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1121335003179 2-isopropylmalate synthase; Validated; Region: PRK03739 1121335003180 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1121335003181 active site 1121335003182 catalytic residues [active] 1121335003183 metal binding site [ion binding]; metal-binding site 1121335003184 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1121335003185 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1121335003186 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1121335003187 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335003188 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335003189 Integrase core domain; Region: rve; pfam00665 1121335003190 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1121335003191 Sm and related proteins; Region: Sm_like; cl00259 1121335003192 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1121335003193 putative oligomer interface [polypeptide binding]; other site 1121335003194 putative RNA binding site [nucleotide binding]; other site 1121335003195 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1121335003196 NusA N-terminal domain; Region: NusA_N; pfam08529 1121335003197 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1121335003198 RNA binding site [nucleotide binding]; other site 1121335003199 homodimer interface [polypeptide binding]; other site 1121335003200 NusA-like KH domain; Region: KH_5; pfam13184 1121335003201 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121335003202 G-X-X-G motif; other site 1121335003203 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1121335003204 putative RNA binding cleft [nucleotide binding]; other site 1121335003205 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1121335003206 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121335003207 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121335003208 translation initiation factor IF-2; Region: IF-2; TIGR00487 1121335003209 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1121335003210 G1 box; other site 1121335003211 putative GEF interaction site [polypeptide binding]; other site 1121335003212 GTP/Mg2+ binding site [chemical binding]; other site 1121335003213 Switch I region; other site 1121335003214 G2 box; other site 1121335003215 G3 box; other site 1121335003216 Switch II region; other site 1121335003217 G4 box; other site 1121335003218 G5 box; other site 1121335003219 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1121335003220 Translation-initiation factor 2; Region: IF-2; pfam11987 1121335003221 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1121335003222 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1121335003223 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121335003224 DHH family; Region: DHH; pfam01368 1121335003225 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 1121335003226 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1121335003227 RNA binding site [nucleotide binding]; other site 1121335003228 active site 1121335003229 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1121335003230 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1121335003231 active site 1121335003232 Riboflavin kinase; Region: Flavokinase; pfam01687 1121335003233 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1121335003234 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121335003235 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121335003236 PspC domain; Region: PspC; pfam04024 1121335003237 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1121335003238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335003239 active site 1121335003240 phosphorylation site [posttranslational modification] 1121335003241 intermolecular recognition site; other site 1121335003242 dimerization interface [polypeptide binding]; other site 1121335003243 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1121335003244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121335003245 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335003246 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1121335003247 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1121335003248 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121335003249 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121335003250 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121335003251 carboxyltransferase (CT) interaction site; other site 1121335003252 biotinylation site [posttranslational modification]; other site 1121335003253 oxaloacetate decarboxylase; Provisional; Region: PRK12331 1121335003254 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1121335003255 active site 1121335003256 catalytic residues [active] 1121335003257 metal binding site [ion binding]; metal-binding site 1121335003258 homodimer binding site [polypeptide binding]; other site 1121335003259 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1121335003260 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1121335003261 active site 1121335003262 dimer interface [polypeptide binding]; other site 1121335003263 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1121335003264 dimer interface [polypeptide binding]; other site 1121335003265 active site 1121335003266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335003267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335003268 dimer interface [polypeptide binding]; other site 1121335003269 phosphorylation site [posttranslational modification] 1121335003270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335003271 ATP binding site [chemical binding]; other site 1121335003272 Mg2+ binding site [ion binding]; other site 1121335003273 G-X-G motif; other site 1121335003274 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1121335003275 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1121335003276 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1121335003277 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1121335003278 23S rRNA binding site [nucleotide binding]; other site 1121335003279 L21 binding site [polypeptide binding]; other site 1121335003280 L13 binding site [polypeptide binding]; other site 1121335003281 TIGR00159 family protein; Region: TIGR00159 1121335003282 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1121335003283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1121335003284 YbbR-like protein; Region: YbbR; pfam07949 1121335003285 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1121335003286 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121335003287 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121335003288 PhoU domain; Region: PhoU; pfam01895 1121335003289 PhoU domain; Region: PhoU; pfam01895 1121335003290 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1121335003291 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1121335003292 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1121335003293 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1121335003294 active site 1121335003295 substrate binding site [chemical binding]; other site 1121335003296 metal binding site [ion binding]; metal-binding site 1121335003297 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121335003298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335003299 Coenzyme A binding pocket [chemical binding]; other site 1121335003300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121335003301 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1121335003302 active site 1121335003303 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335003304 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1121335003305 substrate binding site [chemical binding]; other site 1121335003306 active site 1121335003307 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1121335003308 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003309 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003311 dimer interface [polypeptide binding]; other site 1121335003312 conserved gate region; other site 1121335003313 putative PBP binding loops; other site 1121335003314 ABC-ATPase subunit interface; other site 1121335003315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003317 dimer interface [polypeptide binding]; other site 1121335003318 conserved gate region; other site 1121335003319 putative PBP binding loops; other site 1121335003320 ABC-ATPase subunit interface; other site 1121335003321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003322 binding surface 1121335003323 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335003324 TPR motif; other site 1121335003325 Yip1 domain; Region: Yip1; pfam04893 1121335003326 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003328 dimer interface [polypeptide binding]; other site 1121335003329 conserved gate region; other site 1121335003330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335003331 ABC-ATPase subunit interface; other site 1121335003332 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003334 dimer interface [polypeptide binding]; other site 1121335003335 conserved gate region; other site 1121335003336 putative PBP binding loops; other site 1121335003337 ABC-ATPase subunit interface; other site 1121335003338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335003341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335003342 DNA binding site [nucleotide binding] 1121335003343 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335003344 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1121335003345 metal binding site [ion binding]; metal-binding site 1121335003346 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1121335003347 putative metal binding site [ion binding]; other site 1121335003348 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003349 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003350 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003352 dimer interface [polypeptide binding]; other site 1121335003353 conserved gate region; other site 1121335003354 putative PBP binding loops; other site 1121335003355 ABC-ATPase subunit interface; other site 1121335003356 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003358 dimer interface [polypeptide binding]; other site 1121335003359 conserved gate region; other site 1121335003360 ABC-ATPase subunit interface; other site 1121335003361 NHL repeat; Region: NHL; pfam01436 1121335003362 NHL repeat; Region: NHL; pfam01436 1121335003363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003364 binding surface 1121335003365 TPR repeat; Region: TPR_11; pfam13414 1121335003366 TPR motif; other site 1121335003367 Yip1 domain; Region: Yip1; pfam04893 1121335003368 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003369 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1121335003370 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003372 dimer interface [polypeptide binding]; other site 1121335003373 conserved gate region; other site 1121335003374 ABC-ATPase subunit interface; other site 1121335003375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003377 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1121335003378 putative metal binding site [ion binding]; other site 1121335003379 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1121335003380 Domain of unknown function (DUF377); Region: DUF377; pfam04041 1121335003381 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1121335003382 active site 1121335003383 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121335003384 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121335003385 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1121335003386 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121335003387 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1121335003388 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1121335003389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1121335003390 NAD-dependent deacetylase; Provisional; Region: PRK00481 1121335003391 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1121335003392 NAD+ binding site [chemical binding]; other site 1121335003393 substrate binding site [chemical binding]; other site 1121335003394 Zn binding site [ion binding]; other site 1121335003395 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1121335003396 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121335003397 YGGT family; Region: YGGT; cl00508 1121335003398 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 1121335003399 dimer interface [polypeptide binding]; other site 1121335003400 Citrate synthase; Region: Citrate_synt; pfam00285 1121335003401 active site 1121335003402 citrylCoA binding site [chemical binding]; other site 1121335003403 oxalacetate/citrate binding site [chemical binding]; other site 1121335003404 coenzyme A binding site [chemical binding]; other site 1121335003405 catalytic triad [active] 1121335003406 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1121335003407 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121335003408 Walker A/P-loop; other site 1121335003409 ATP binding site [chemical binding]; other site 1121335003410 Q-loop/lid; other site 1121335003411 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1121335003412 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121335003413 Q-loop/lid; other site 1121335003414 ABC transporter signature motif; other site 1121335003415 Walker B; other site 1121335003416 D-loop; other site 1121335003417 H-loop/switch region; other site 1121335003418 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1121335003419 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1121335003420 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121335003421 GTP binding site [chemical binding]; other site 1121335003422 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 1121335003423 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121335003424 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 1121335003425 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121335003426 active site 1121335003427 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1121335003428 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1121335003429 active site 1121335003430 YlzJ-like protein; Region: YlzJ; pfam14035 1121335003431 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1121335003432 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1121335003433 ligand binding site [chemical binding]; other site 1121335003434 NAD binding site [chemical binding]; other site 1121335003435 dimerization interface [polypeptide binding]; other site 1121335003436 catalytic site [active] 1121335003437 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1121335003438 putative L-serine binding site [chemical binding]; other site 1121335003439 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1121335003440 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121335003441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335003442 FeS/SAM binding site; other site 1121335003443 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1121335003444 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1121335003445 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1121335003446 active site 2 [active] 1121335003447 active site 1 [active] 1121335003448 putative phosphate acyltransferase; Provisional; Region: PRK05331 1121335003449 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1121335003450 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1121335003451 dimer interface [polypeptide binding]; other site 1121335003452 active site 1121335003453 CoA binding pocket [chemical binding]; other site 1121335003454 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121335003455 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121335003456 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1121335003457 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1121335003458 NAD(P) binding site [chemical binding]; other site 1121335003459 homotetramer interface [polypeptide binding]; other site 1121335003460 homodimer interface [polypeptide binding]; other site 1121335003461 active site 1121335003462 acyl carrier protein; Provisional; Region: acpP; PRK00982 1121335003463 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1121335003464 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1121335003465 dimer interface [polypeptide binding]; other site 1121335003466 active site 1121335003467 ribonuclease III; Reviewed; Region: rnc; PRK00102 1121335003468 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1121335003469 dimerization interface [polypeptide binding]; other site 1121335003470 active site 1121335003471 metal binding site [ion binding]; metal-binding site 1121335003472 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1121335003473 dsRNA binding site [nucleotide binding]; other site 1121335003474 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1121335003475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335003476 FeS/SAM binding site; other site 1121335003477 Fumble; Region: Fumble; cl17357 1121335003478 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1121335003479 Predicted membrane protein [Function unknown]; Region: COG4684 1121335003480 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1121335003481 fumarate hydratase; Provisional; Region: PRK06246 1121335003482 Predicted methyltransferases [General function prediction only]; Region: COG0313 1121335003483 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1121335003484 putative SAM binding site [chemical binding]; other site 1121335003485 putative homodimer interface [polypeptide binding]; other site 1121335003486 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1121335003487 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1121335003488 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1121335003489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335003490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335003491 active site 1121335003492 phosphorylation site [posttranslational modification] 1121335003493 intermolecular recognition site; other site 1121335003494 dimerization interface [polypeptide binding]; other site 1121335003495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335003496 DNA binding site [nucleotide binding] 1121335003497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335003498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335003499 dimerization interface [polypeptide binding]; other site 1121335003500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335003501 dimer interface [polypeptide binding]; other site 1121335003502 phosphorylation site [posttranslational modification] 1121335003503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335003504 ATP binding site [chemical binding]; other site 1121335003505 Mg2+ binding site [ion binding]; other site 1121335003506 G-X-G motif; other site 1121335003507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335003508 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335003509 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335003510 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121335003511 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121335003512 protein binding site [polypeptide binding]; other site 1121335003513 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1121335003514 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1121335003515 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1121335003516 dimerization interface [polypeptide binding]; other site 1121335003517 ATP binding site [chemical binding]; other site 1121335003518 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1121335003519 dimerization interface [polypeptide binding]; other site 1121335003520 ATP binding site [chemical binding]; other site 1121335003521 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1121335003522 putative active site [active] 1121335003523 catalytic triad [active] 1121335003524 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1121335003525 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1121335003526 VanW like protein; Region: VanW; pfam04294 1121335003527 Putative amidase domain; Region: Amidase_6; pfam12671 1121335003528 HEAT repeats; Region: HEAT_2; pfam13646 1121335003529 HEAT repeat; Region: HEAT; pfam02985 1121335003530 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335003531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1121335003532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1121335003533 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335003534 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121335003535 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1121335003536 S-layer homology domain; Region: SLH; pfam00395 1121335003537 S-layer homology domain; Region: SLH; pfam00395 1121335003538 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1121335003539 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121335003540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335003541 putative DNA binding site [nucleotide binding]; other site 1121335003542 putative Zn2+ binding site [ion binding]; other site 1121335003543 MarR family; Region: MarR_2; cl17246 1121335003544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003545 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335003547 Walker A/P-loop; other site 1121335003548 ATP binding site [chemical binding]; other site 1121335003549 Q-loop/lid; other site 1121335003550 ABC transporter signature motif; other site 1121335003551 Walker B; other site 1121335003552 D-loop; other site 1121335003553 H-loop/switch region; other site 1121335003554 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003556 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335003557 Walker A/P-loop; other site 1121335003558 ATP binding site [chemical binding]; other site 1121335003559 Q-loop/lid; other site 1121335003560 ABC transporter signature motif; other site 1121335003561 Walker B; other site 1121335003562 D-loop; other site 1121335003563 H-loop/switch region; other site 1121335003564 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335003565 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1121335003566 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1121335003567 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1121335003568 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1121335003569 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1121335003570 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1121335003571 dimer interface [polypeptide binding]; other site 1121335003572 active site 1121335003573 catalytic residue [active] 1121335003574 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1121335003575 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121335003576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1121335003577 signal recognition particle protein; Provisional; Region: PRK10867 1121335003578 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1121335003579 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121335003580 P loop; other site 1121335003581 GTP binding site [chemical binding]; other site 1121335003582 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1121335003583 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1121335003584 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1121335003585 hypothetical protein; Provisional; Region: PRK00468 1121335003586 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121335003587 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121335003588 catalytic residues [active] 1121335003589 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 1121335003590 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1121335003591 active site 1121335003592 putative substrate binding pocket [chemical binding]; other site 1121335003593 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1121335003594 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1121335003595 Colicin V production protein; Region: Colicin_V; pfam02674 1121335003596 S-layer homology domain; Region: SLH; pfam00395 1121335003597 S-layer homology domain; Region: SLH; pfam00395 1121335003598 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1121335003599 C-terminal peptidase (prc); Region: prc; TIGR00225 1121335003600 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1121335003601 protein binding site [polypeptide binding]; other site 1121335003602 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1121335003603 Catalytic dyad [active] 1121335003604 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335003605 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1121335003606 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1121335003607 putative substrate binding site [chemical binding]; other site 1121335003608 putative ATP binding site [chemical binding]; other site 1121335003609 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1121335003610 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1121335003611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335003612 MULE transposase domain; Region: MULE; pfam10551 1121335003613 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1121335003614 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335003615 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335003616 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335003617 metal binding site [ion binding]; metal-binding site 1121335003618 ligand binding site [chemical binding]; other site 1121335003619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335003620 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335003621 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121335003622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335003623 Coenzyme A binding pocket [chemical binding]; other site 1121335003624 putative alpha-glucosidase; Provisional; Region: PRK10658 1121335003625 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1121335003626 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1121335003627 active site 1121335003628 homotrimer interface [polypeptide binding]; other site 1121335003629 catalytic site [active] 1121335003630 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1121335003631 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335003632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335003634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003635 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 1121335003636 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1121335003637 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1121335003638 active site 1121335003639 (T/H)XGH motif; other site 1121335003640 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335003641 Zn2+ binding site [ion binding]; other site 1121335003642 Mg2+ binding site [ion binding]; other site 1121335003643 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121335003644 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121335003645 Catalytic site [active] 1121335003646 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335003647 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335003648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335003649 MULE transposase domain; Region: MULE; pfam10551 1121335003650 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003651 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003652 MULE transposase domain; Region: MULE; pfam10551 1121335003653 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1121335003654 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121335003655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335003656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335003657 non-specific DNA binding site [nucleotide binding]; other site 1121335003658 salt bridge; other site 1121335003659 sequence-specific DNA binding site [nucleotide binding]; other site 1121335003660 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 1121335003661 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003662 MULE transposase domain; Region: MULE; pfam10551 1121335003663 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1121335003664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335003665 non-specific DNA binding site [nucleotide binding]; other site 1121335003666 salt bridge; other site 1121335003667 sequence-specific DNA binding site [nucleotide binding]; other site 1121335003668 Cupin domain; Region: Cupin_2; pfam07883 1121335003669 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1121335003670 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1121335003671 Walker A/P-loop; other site 1121335003672 ATP binding site [chemical binding]; other site 1121335003673 Q-loop/lid; other site 1121335003674 ABC transporter signature motif; other site 1121335003675 Walker B; other site 1121335003676 D-loop; other site 1121335003677 H-loop/switch region; other site 1121335003678 TOBE domain; Region: TOBE_2; pfam08402 1121335003679 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1121335003680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003681 dimer interface [polypeptide binding]; other site 1121335003682 conserved gate region; other site 1121335003683 putative PBP binding loops; other site 1121335003684 ABC-ATPase subunit interface; other site 1121335003685 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1121335003686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003687 dimer interface [polypeptide binding]; other site 1121335003688 conserved gate region; other site 1121335003689 putative PBP binding loops; other site 1121335003690 ABC-ATPase subunit interface; other site 1121335003691 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1121335003692 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1121335003693 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1121335003694 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1121335003695 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1121335003696 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1121335003697 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1121335003698 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1121335003699 homodimer interface [polypeptide binding]; other site 1121335003700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335003701 catalytic residue [active] 1121335003702 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1121335003703 thymidylate kinase; Validated; Region: tmk; PRK00698 1121335003704 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1121335003705 TMP-binding site; other site 1121335003706 ATP-binding site [chemical binding]; other site 1121335003707 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1121335003708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003709 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1121335003710 Walker A motif; other site 1121335003711 ATP binding site [chemical binding]; other site 1121335003712 DNA polymerase III subunit delta'; Validated; Region: PRK07132 1121335003713 Walker B motif; other site 1121335003714 arginine finger; other site 1121335003715 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1121335003716 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335003717 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121335003718 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1121335003719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335003720 Fumarase C-terminus; Region: Fumerase_C; cl00795 1121335003721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335003722 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335003723 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335003724 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1121335003725 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335003726 dimer interface [polypeptide binding]; other site 1121335003727 PYR/PP interface [polypeptide binding]; other site 1121335003728 TPP binding site [chemical binding]; other site 1121335003729 substrate binding site [chemical binding]; other site 1121335003730 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335003731 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1121335003732 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1121335003733 TPP-binding site [chemical binding]; other site 1121335003734 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1121335003735 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1121335003736 QueT transporter; Region: QueT; pfam06177 1121335003737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121335003738 ribonuclease R; Region: RNase_R; TIGR02063 1121335003739 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1121335003740 RNB domain; Region: RNB; pfam00773 1121335003741 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1121335003742 RNA binding site [nucleotide binding]; other site 1121335003743 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003744 MULE transposase domain; Region: MULE; pfam10551 1121335003745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335003746 MULE transposase domain; Region: MULE; pfam10551 1121335003747 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1121335003748 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1121335003749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335003750 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1121335003751 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1121335003752 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335003753 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121335003754 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121335003755 Type II/IV secretion system protein; Region: T2SE; pfam00437 1121335003756 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121335003757 Walker A motif; other site 1121335003758 ATP binding site [chemical binding]; other site 1121335003759 Walker B motif; other site 1121335003760 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1121335003761 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1121335003762 Walker A motif; other site 1121335003763 ATP binding site [chemical binding]; other site 1121335003764 Walker B motif; other site 1121335003765 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1121335003766 Cell division protein FtsA; Region: FtsA; cl17206 1121335003767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003768 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1121335003769 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121335003770 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121335003771 Uncharacterized protein family (UPF0179); Region: UPF0179; cl00805 1121335003772 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1121335003773 S-layer homology domain; Region: SLH; pfam00395 1121335003774 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335003775 metal ion-dependent adhesion site (MIDAS); other site 1121335003776 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1121335003777 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1121335003778 homodimer interface [polypeptide binding]; other site 1121335003779 substrate-cofactor binding pocket; other site 1121335003780 catalytic residue [active] 1121335003781 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1121335003782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335003783 active site 1121335003784 motif I; other site 1121335003785 motif II; other site 1121335003786 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1121335003787 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121335003788 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121335003789 shikimate binding site; other site 1121335003790 NAD(P) binding site [chemical binding]; other site 1121335003791 Late competence development protein ComFB; Region: ComFB; pfam10719 1121335003792 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335003793 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335003794 Walker A/P-loop; other site 1121335003795 ATP binding site [chemical binding]; other site 1121335003796 Q-loop/lid; other site 1121335003797 ABC transporter signature motif; other site 1121335003798 Walker B; other site 1121335003799 D-loop; other site 1121335003800 H-loop/switch region; other site 1121335003801 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335003802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003803 dimer interface [polypeptide binding]; other site 1121335003804 conserved gate region; other site 1121335003805 putative PBP binding loops; other site 1121335003806 ABC-ATPase subunit interface; other site 1121335003807 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335003808 NMT1-like family; Region: NMT1_2; pfam13379 1121335003809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1121335003810 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1121335003811 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1121335003812 Glucose inhibited division protein A; Region: GIDA; pfam01134 1121335003813 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1121335003814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003815 Walker A motif; other site 1121335003816 ATP binding site [chemical binding]; other site 1121335003817 Walker B motif; other site 1121335003818 arginine finger; other site 1121335003819 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1121335003820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003821 Walker A motif; other site 1121335003822 ATP binding site [chemical binding]; other site 1121335003823 Walker B motif; other site 1121335003824 arginine finger; other site 1121335003825 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1121335003826 propionate/acetate kinase; Provisional; Region: PRK12379 1121335003827 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121335003828 nucleotide binding site [chemical binding]; other site 1121335003829 butyrate kinase; Provisional; Region: PRK03011 1121335003830 aspartate kinase; Reviewed; Region: PRK09034 1121335003831 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1121335003832 nucleotide binding site [chemical binding]; other site 1121335003833 substrate binding site [chemical binding]; other site 1121335003834 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121335003835 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1121335003836 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003837 MULE transposase domain; Region: MULE; pfam10551 1121335003838 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1121335003839 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1121335003840 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1121335003841 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1121335003842 active site 1121335003843 dimer interface [polypeptide binding]; other site 1121335003844 metal binding site [ion binding]; metal-binding site 1121335003845 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1121335003846 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1121335003847 hinge; other site 1121335003848 active site 1121335003849 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1121335003850 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1121335003851 Tetramer interface [polypeptide binding]; other site 1121335003852 active site 1121335003853 FMN-binding site [chemical binding]; other site 1121335003854 hypothetical protein; Provisional; Region: PRK07248 1121335003855 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1121335003856 Prephenate dehydratase; Region: PDT; pfam00800 1121335003857 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1121335003858 putative L-Phe binding site [chemical binding]; other site 1121335003859 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1121335003860 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121335003861 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121335003862 shikimate binding site; other site 1121335003863 NAD(P) binding site [chemical binding]; other site 1121335003864 shikimate kinase; Reviewed; Region: aroK; PRK00131 1121335003865 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121335003866 ADP binding site [chemical binding]; other site 1121335003867 magnesium binding site [ion binding]; other site 1121335003868 putative shikimate binding site; other site 1121335003869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1121335003870 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121335003871 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335003872 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335003873 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335003874 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1121335003875 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1121335003876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335003877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335003878 homodimer interface [polypeptide binding]; other site 1121335003879 catalytic residue [active] 1121335003880 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1121335003881 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1121335003882 tetramer interface [polypeptide binding]; other site 1121335003883 active site 1121335003884 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121335003885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335003886 DNA-binding site [nucleotide binding]; DNA binding site 1121335003887 UTRA domain; Region: UTRA; pfam07702 1121335003888 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335003889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121335003890 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335003891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003893 dimer interface [polypeptide binding]; other site 1121335003894 ABC-ATPase subunit interface; other site 1121335003895 putative PBP binding loops; other site 1121335003896 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335003897 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335003898 Walker A/P-loop; other site 1121335003899 ATP binding site [chemical binding]; other site 1121335003900 Q-loop/lid; other site 1121335003901 ABC transporter signature motif; other site 1121335003902 Walker B; other site 1121335003903 D-loop; other site 1121335003904 H-loop/switch region; other site 1121335003905 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1121335003906 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1121335003907 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1121335003908 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121335003909 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1121335003910 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1121335003911 Preprotein translocase subunit; Region: YajC; pfam02699 1121335003912 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1121335003913 RimM N-terminal domain; Region: RimM; pfam01782 1121335003914 PRC-barrel domain; Region: PRC; pfam05239 1121335003915 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1121335003916 recombination factor protein RarA; Reviewed; Region: PRK13342 1121335003917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003918 Walker A motif; other site 1121335003919 ATP binding site [chemical binding]; other site 1121335003920 Walker B motif; other site 1121335003921 arginine finger; other site 1121335003922 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1121335003923 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1121335003924 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1121335003925 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 1121335003926 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1121335003927 oligomer interface [polypeptide binding]; other site 1121335003928 putative active site [active] 1121335003929 metal binding site [ion binding]; metal-binding site 1121335003930 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335003931 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1121335003932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003933 binding surface 1121335003934 TPR motif; other site 1121335003935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003936 binding surface 1121335003937 TPR motif; other site 1121335003938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003939 binding surface 1121335003940 TPR motif; other site 1121335003941 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1121335003942 Active site serine [active] 1121335003943 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1121335003944 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335003945 active site 1121335003946 DNA binding site [nucleotide binding] 1121335003947 Int/Topo IB signature motif; other site 1121335003948 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1121335003949 active site 1121335003950 catalytic site [active] 1121335003951 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1121335003952 regulatory protein CsrD; Provisional; Region: PRK11059 1121335003953 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121335003954 Catalytic site [active] 1121335003955 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1121335003956 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121335003957 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1121335003958 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1121335003959 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1121335003960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003961 binding surface 1121335003962 TPR motif; other site 1121335003963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335003964 active site 1121335003965 I-site; other site 1121335003966 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1121335003967 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1121335003968 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1121335003969 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 1121335003970 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 1121335003971 dimerization interface [polypeptide binding]; other site 1121335003972 putative ATP binding site [chemical binding]; other site 1121335003973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 1121335003974 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 1121335003975 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1121335003976 VanW like protein; Region: VanW; pfam04294 1121335003977 G5 domain; Region: G5; pfam07501 1121335003978 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1121335003979 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1121335003980 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1121335003981 Ligand Binding Site [chemical binding]; other site 1121335003982 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121335003983 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121335003984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335003985 catalytic residue [active] 1121335003986 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1121335003987 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335003988 active site 1121335003989 metal binding site [ion binding]; metal-binding site 1121335003990 homotetramer interface [polypeptide binding]; other site 1121335003991 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1121335003992 active site 1121335003993 dimerization interface [polypeptide binding]; other site 1121335003994 ribonuclease PH; Reviewed; Region: rph; PRK00173 1121335003995 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1121335003996 hexamer interface [polypeptide binding]; other site 1121335003997 active site 1121335003998 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335003999 AMIN domain; Region: AMIN; pfam11741 1121335004000 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335004001 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335004002 active site 1121335004003 metal binding site [ion binding]; metal-binding site 1121335004004 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 1121335004005 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121335004006 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121335004007 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121335004008 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335004009 Protein of unknown function DUF116; Region: DUF116; pfam01976 1121335004010 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1121335004011 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1121335004012 putative active site [active] 1121335004013 substrate binding site [chemical binding]; other site 1121335004014 putative cosubstrate binding site; other site 1121335004015 catalytic site [active] 1121335004016 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1121335004017 substrate binding site [chemical binding]; other site 1121335004018 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121335004019 active site 1121335004020 catalytic residues [active] 1121335004021 metal binding site [ion binding]; metal-binding site 1121335004022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335004023 primosomal protein N' Region: priA; TIGR00595 1121335004024 ATP binding site [chemical binding]; other site 1121335004025 putative Mg++ binding site [ion binding]; other site 1121335004026 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 1121335004027 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 1121335004028 Zn binding sites [ion binding]; other site 1121335004029 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1121335004030 single-stranded DNA-binding protein; Provisional; Region: PRK05813 1121335004031 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121335004032 dimer interface [polypeptide binding]; other site 1121335004033 ssDNA binding site [nucleotide binding]; other site 1121335004034 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121335004035 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1121335004036 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1121335004037 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1121335004038 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1121335004039 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121335004040 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121335004041 active site 1121335004042 ATP binding site [chemical binding]; other site 1121335004043 substrate binding site [chemical binding]; other site 1121335004044 activation loop (A-loop); other site 1121335004045 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1121335004046 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1121335004047 hinge region; other site 1121335004048 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1121335004049 putative nucleotide binding site [chemical binding]; other site 1121335004050 uridine monophosphate binding site [chemical binding]; other site 1121335004051 homohexameric interface [polypeptide binding]; other site 1121335004052 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1121335004053 UBA/TS-N domain; Region: UBA; pfam00627 1121335004054 Elongation factor TS; Region: EF_TS; pfam00889 1121335004055 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1121335004056 rRNA interaction site [nucleotide binding]; other site 1121335004057 S8 interaction site; other site 1121335004058 putative laminin-1 binding site; other site 1121335004059 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1121335004060 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1121335004061 ATP binding site [chemical binding]; other site 1121335004062 Walker A motif; other site 1121335004063 hexamer interface [polypeptide binding]; other site 1121335004064 Walker B motif; other site 1121335004065 AAA domain; Region: AAA_31; pfam13614 1121335004066 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1121335004067 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1121335004068 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1121335004069 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121335004070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004071 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335004072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004073 DNA binding residues [nucleotide binding] 1121335004074 DNA primase, catalytic core; Region: dnaG; TIGR01391 1121335004075 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1121335004076 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1121335004077 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1121335004078 active site 1121335004079 metal binding site [ion binding]; metal-binding site 1121335004080 interdomain interaction site; other site 1121335004081 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1121335004082 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1121335004083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004084 Zn2+ binding site [ion binding]; other site 1121335004085 Mg2+ binding site [ion binding]; other site 1121335004086 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1121335004087 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1121335004088 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1121335004089 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1121335004090 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1121335004091 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1121335004092 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121335004093 putative valine binding site [chemical binding]; other site 1121335004094 dimer interface [polypeptide binding]; other site 1121335004095 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1121335004096 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1121335004097 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 1121335004098 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121335004099 PYR/PP interface [polypeptide binding]; other site 1121335004100 dimer interface [polypeptide binding]; other site 1121335004101 TPP binding site [chemical binding]; other site 1121335004102 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121335004103 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121335004104 TPP-binding site [chemical binding]; other site 1121335004105 dimer interface [polypeptide binding]; other site 1121335004106 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1121335004107 tartrate dehydrogenase; Region: TTC; TIGR02089 1121335004108 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1121335004109 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1121335004110 substrate binding site [chemical binding]; other site 1121335004111 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1121335004112 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1121335004113 substrate binding site [chemical binding]; other site 1121335004114 ligand binding site [chemical binding]; other site 1121335004115 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1121335004116 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1121335004117 putative active site [active] 1121335004118 putative metal binding site [ion binding]; other site 1121335004119 DNA topoisomerase I; Validated; Region: PRK05582 1121335004120 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1121335004121 active site 1121335004122 interdomain interaction site; other site 1121335004123 putative metal-binding site [ion binding]; other site 1121335004124 nucleotide binding site [chemical binding]; other site 1121335004125 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1121335004126 domain I; other site 1121335004127 DNA binding groove [nucleotide binding] 1121335004128 phosphate binding site [ion binding]; other site 1121335004129 domain II; other site 1121335004130 domain III; other site 1121335004131 nucleotide binding site [chemical binding]; other site 1121335004132 catalytic site [active] 1121335004133 domain IV; other site 1121335004134 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121335004135 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121335004136 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1121335004137 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121335004138 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1121335004139 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335004140 beta-D-glucuronidase; Provisional; Region: PRK10150 1121335004141 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335004142 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335004143 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1121335004144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335004145 FeS/SAM binding site; other site 1121335004146 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121335004147 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1121335004148 putative active site [active] 1121335004149 dimerization interface [polypeptide binding]; other site 1121335004150 putative tRNAtyr binding site [nucleotide binding]; other site 1121335004151 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121335004152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004153 Zn2+ binding site [ion binding]; other site 1121335004154 Mg2+ binding site [ion binding]; other site 1121335004155 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121335004156 synthetase active site [active] 1121335004157 NTP binding site [chemical binding]; other site 1121335004158 metal binding site [ion binding]; metal-binding site 1121335004159 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1121335004160 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1121335004161 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1121335004162 DHH family; Region: DHH; pfam01368 1121335004163 DHHA1 domain; Region: DHHA1; pfam02272 1121335004164 Protein of unknown function (DUF3228); Region: DUF3228; pfam11539 1121335004165 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1121335004166 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1121335004167 nucleotide binding site/active site [active] 1121335004168 HIT family signature motif; other site 1121335004169 catalytic residue [active] 1121335004170 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1121335004171 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1121335004172 motif 1; other site 1121335004173 active site 1121335004174 motif 2; other site 1121335004175 motif 3; other site 1121335004176 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1121335004177 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121335004178 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1121335004179 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121335004180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335004181 active site 1121335004182 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121335004183 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121335004184 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1121335004185 PRC-barrel domain; Region: PRC; pfam05239 1121335004186 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1121335004187 Putative amidase domain; Region: Amidase_6; pfam12671 1121335004188 sporulation sigma factor SigF; Validated; Region: PRK05572 1121335004189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004190 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335004191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004192 DNA binding residues [nucleotide binding] 1121335004193 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1121335004194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004195 ATP binding site [chemical binding]; other site 1121335004196 Mg2+ binding site [ion binding]; other site 1121335004197 G-X-G motif; other site 1121335004198 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121335004199 anti sigma factor interaction site; other site 1121335004200 regulatory phosphorylation site [posttranslational modification]; other site 1121335004201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1121335004202 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1121335004203 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1121335004204 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 1121335004205 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1121335004206 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1121335004207 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1121335004208 phosphate binding site [ion binding]; other site 1121335004209 putative substrate binding pocket [chemical binding]; other site 1121335004210 dimer interface [polypeptide binding]; other site 1121335004211 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1121335004212 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1121335004213 FAD binding domain; Region: FAD_binding_4; pfam01565 1121335004214 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1121335004215 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1121335004216 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1121335004217 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1121335004218 Hpr binding site; other site 1121335004219 active site 1121335004220 homohexamer subunit interaction site [polypeptide binding]; other site 1121335004221 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1121335004222 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1121335004223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335004224 catalytic residue [active] 1121335004225 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 1121335004226 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 1121335004227 Predicted membrane protein [Function unknown]; Region: COG2246 1121335004228 GtrA-like protein; Region: GtrA; pfam04138 1121335004229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335004230 hypothetical protein; Provisional; Region: PRK07233 1121335004231 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121335004232 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121335004233 Ligand binding site; other site 1121335004234 Putative Catalytic site; other site 1121335004235 DXD motif; other site 1121335004236 Cation efflux family; Region: Cation_efflux; cl00316 1121335004237 putative oxidoreductase; Provisional; Region: PRK11445 1121335004238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335004239 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1121335004240 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335004241 motif 1; other site 1121335004242 dimer interface [polypeptide binding]; other site 1121335004243 active site 1121335004244 motif 2; other site 1121335004245 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1121335004246 putative deacylase active site [active] 1121335004247 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335004248 active site 1121335004249 motif 3; other site 1121335004250 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1121335004251 anticodon binding site; other site 1121335004252 HD domain; Region: HD_3; pfam13023 1121335004253 heat shock protein 90; Provisional; Region: PRK05218 1121335004254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004255 ATP binding site [chemical binding]; other site 1121335004256 Mg2+ binding site [ion binding]; other site 1121335004257 G-X-G motif; other site 1121335004258 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1121335004259 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121335004260 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121335004261 RIP metalloprotease RseP; Region: TIGR00054 1121335004262 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121335004263 active site 1121335004264 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121335004265 protein binding site [polypeptide binding]; other site 1121335004266 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121335004267 protein binding site [polypeptide binding]; other site 1121335004268 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121335004269 putative substrate binding region [chemical binding]; other site 1121335004270 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1121335004271 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1121335004272 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1121335004273 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1121335004274 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121335004275 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121335004276 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1121335004277 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1121335004278 catalytic residue [active] 1121335004279 putative FPP diphosphate binding site; other site 1121335004280 putative FPP binding hydrophobic cleft; other site 1121335004281 dimer interface [polypeptide binding]; other site 1121335004282 putative IPP diphosphate binding site; other site 1121335004283 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1121335004284 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121335004285 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121335004286 phosphopeptide binding site; other site 1121335004287 TadE-like protein; Region: TadE; pfam07811 1121335004288 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1121335004289 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1121335004290 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121335004291 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1121335004292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335004293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335004294 dimerization interface [polypeptide binding]; other site 1121335004295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335004296 dimer interface [polypeptide binding]; other site 1121335004297 phosphorylation site [posttranslational modification] 1121335004298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004299 ATP binding site [chemical binding]; other site 1121335004300 Mg2+ binding site [ion binding]; other site 1121335004301 G-X-G motif; other site 1121335004302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335004303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335004304 active site 1121335004305 phosphorylation site [posttranslational modification] 1121335004306 intermolecular recognition site; other site 1121335004307 dimerization interface [polypeptide binding]; other site 1121335004308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335004309 DNA binding site [nucleotide binding] 1121335004310 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 1121335004311 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1121335004312 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121335004313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121335004314 putative acyl-acceptor binding pocket; other site 1121335004315 GMP synthase; Reviewed; Region: guaA; PRK00074 1121335004316 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1121335004317 AMP/PPi binding site [chemical binding]; other site 1121335004318 candidate oxyanion hole; other site 1121335004319 catalytic triad [active] 1121335004320 potential glutamine specificity residues [chemical binding]; other site 1121335004321 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1121335004322 ATP Binding subdomain [chemical binding]; other site 1121335004323 Ligand Binding sites [chemical binding]; other site 1121335004324 Dimerization subdomain; other site 1121335004325 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1121335004326 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1121335004327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335004328 S-adenosylmethionine binding site [chemical binding]; other site 1121335004329 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 1121335004330 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1121335004331 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335004332 dimer interface [polypeptide binding]; other site 1121335004333 PYR/PP interface [polypeptide binding]; other site 1121335004334 TPP binding site [chemical binding]; other site 1121335004335 substrate binding site [chemical binding]; other site 1121335004336 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121335004337 Domain of unknown function; Region: EKR; pfam10371 1121335004338 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1121335004339 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335004340 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1121335004341 TPP-binding site [chemical binding]; other site 1121335004342 dimer interface [polypeptide binding]; other site 1121335004343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335004344 MULE transposase domain; Region: MULE; pfam10551 1121335004345 Coat F domain; Region: Coat_F; pfam07875 1121335004346 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1121335004347 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121335004348 homodimer interface [polypeptide binding]; other site 1121335004349 substrate-cofactor binding pocket; other site 1121335004350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335004351 catalytic residue [active] 1121335004352 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1121335004353 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1121335004354 proposed active site lysine [active] 1121335004355 conserved cys residue [active] 1121335004356 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1121335004357 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1121335004358 generic binding surface II; other site 1121335004359 generic binding surface I; other site 1121335004360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004361 Zn2+ binding site [ion binding]; other site 1121335004362 Mg2+ binding site [ion binding]; other site 1121335004363 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121335004364 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004365 Zn2+ binding site [ion binding]; other site 1121335004366 Mg2+ binding site [ion binding]; other site 1121335004367 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1121335004368 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1121335004369 active site 1121335004370 substrate binding site [chemical binding]; other site 1121335004371 metal binding site [ion binding]; metal-binding site 1121335004372 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1121335004373 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335004374 putative active site [active] 1121335004375 metal binding site [ion binding]; metal-binding site 1121335004376 homodimer binding site [polypeptide binding]; other site 1121335004377 phosphodiesterase; Provisional; Region: PRK12704 1121335004378 uncharacterized domain HDIG; Region: HDIG; TIGR00277 1121335004379 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1121335004380 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1121335004381 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1121335004382 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1121335004383 homodimer interface [polypeptide binding]; other site 1121335004384 NADP binding site [chemical binding]; other site 1121335004385 substrate binding site [chemical binding]; other site 1121335004386 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 1121335004387 TPR repeat; Region: TPR_11; pfam13414 1121335004388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004389 binding surface 1121335004390 TPR motif; other site 1121335004391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335004392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004393 binding surface 1121335004394 TPR repeat; Region: TPR_11; pfam13414 1121335004395 TPR motif; other site 1121335004396 TPR repeat; Region: TPR_11; pfam13414 1121335004397 TPR repeat; Region: TPR_11; pfam13414 1121335004398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004399 binding surface 1121335004400 TPR motif; other site 1121335004401 TPR repeat; Region: TPR_11; pfam13414 1121335004402 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1121335004403 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1121335004404 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121335004405 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1121335004406 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1121335004407 dimerization interface [polypeptide binding]; other site 1121335004408 putative active cleft [active] 1121335004409 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1121335004410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335004411 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1121335004412 active site 1121335004413 DNA binding site [nucleotide binding] 1121335004414 Int/Topo IB signature motif; other site 1121335004415 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1121335004416 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1121335004417 dimer interface [polypeptide binding]; other site 1121335004418 ADP-ribose binding site [chemical binding]; other site 1121335004419 active site 1121335004420 nudix motif; other site 1121335004421 metal binding site [ion binding]; metal-binding site 1121335004422 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1121335004423 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121335004424 active site 1121335004425 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1121335004426 pyrroline-5-carboxylate reductase; Region: PLN02688 1121335004427 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1121335004428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004429 Walker A motif; other site 1121335004430 ATP binding site [chemical binding]; other site 1121335004431 Walker B motif; other site 1121335004432 arginine finger; other site 1121335004433 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1121335004434 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1121335004435 RuvA N terminal domain; Region: RuvA_N; pfam01330 1121335004436 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1121335004437 active site 1121335004438 putative DNA-binding cleft [nucleotide binding]; other site 1121335004439 dimer interface [polypeptide binding]; other site 1121335004440 argininosuccinate synthase; Provisional; Region: PRK13820 1121335004441 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1121335004442 ANP binding site [chemical binding]; other site 1121335004443 Substrate Binding Site II [chemical binding]; other site 1121335004444 Substrate Binding Site I [chemical binding]; other site 1121335004445 argininosuccinate lyase; Provisional; Region: PRK00855 1121335004446 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1121335004447 active sites [active] 1121335004448 tetramer interface [polypeptide binding]; other site 1121335004449 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121335004450 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1121335004451 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1121335004452 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1121335004453 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121335004454 active site 1121335004455 6-phosphofructokinase; Provisional; Region: PRK03202 1121335004456 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1121335004457 active site 1121335004458 ADP/pyrophosphate binding site [chemical binding]; other site 1121335004459 dimerization interface [polypeptide binding]; other site 1121335004460 allosteric effector site; other site 1121335004461 fructose-1,6-bisphosphate binding site; other site 1121335004462 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 1121335004463 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1121335004464 active site 1121335004465 PHP Thumb interface [polypeptide binding]; other site 1121335004466 metal binding site [ion binding]; metal-binding site 1121335004467 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1121335004468 generic binding surface II; other site 1121335004469 generic binding surface I; other site 1121335004470 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121335004471 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1121335004472 putative active site [active] 1121335004473 putative metal binding site [ion binding]; other site 1121335004474 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1121335004475 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1121335004476 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335004477 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121335004478 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121335004479 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1121335004480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335004481 S-adenosylmethionine binding site [chemical binding]; other site 1121335004482 YceG-like family; Region: YceG; pfam02618 1121335004483 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1121335004484 dimerization interface [polypeptide binding]; other site 1121335004485 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1121335004486 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1121335004487 G1 box; other site 1121335004488 putative GEF interaction site [polypeptide binding]; other site 1121335004489 GTP/Mg2+ binding site [chemical binding]; other site 1121335004490 Switch I region; other site 1121335004491 G2 box; other site 1121335004492 G3 box; other site 1121335004493 Switch II region; other site 1121335004494 G4 box; other site 1121335004495 G5 box; other site 1121335004496 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1121335004497 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1121335004498 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121335004499 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335004500 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1121335004501 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1121335004502 Protein of unknown function DUF58; Region: DUF58; pfam01882 1121335004503 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335004504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004505 Walker A motif; other site 1121335004506 ATP binding site [chemical binding]; other site 1121335004507 Walker B motif; other site 1121335004508 arginine finger; other site 1121335004509 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 1121335004510 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335004511 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335004512 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1121335004513 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1121335004514 putative ATP binding site [chemical binding]; other site 1121335004515 putative substrate interface [chemical binding]; other site 1121335004516 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335004517 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1121335004518 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335004519 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1121335004520 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335004521 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1121335004522 putative active site [active] 1121335004523 Zn binding site [ion binding]; other site 1121335004524 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121335004525 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121335004526 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121335004527 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 1121335004528 LytB protein; Region: LYTB; cl00507 1121335004529 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1121335004530 RNA binding site [nucleotide binding]; other site 1121335004531 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1121335004532 RNA binding site [nucleotide binding]; other site 1121335004533 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1121335004534 RNA binding site [nucleotide binding]; other site 1121335004535 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121335004536 RNA binding site [nucleotide binding]; other site 1121335004537 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121335004538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121335004539 putative acyl-acceptor binding pocket; other site 1121335004540 cytidylate kinase; Provisional; Region: cmk; PRK00023 1121335004541 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1121335004542 CMP-binding site; other site 1121335004543 The sites determining sugar specificity; other site 1121335004544 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1121335004545 hexamer interface [polypeptide binding]; other site 1121335004546 RNA binding site [nucleotide binding]; other site 1121335004547 Histidine-zinc binding site [chemical binding]; other site 1121335004548 HI0933-like protein; Region: HI0933_like; pfam03486 1121335004549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335004550 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1121335004551 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1121335004552 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1121335004553 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1121335004554 putative active site [active] 1121335004555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335004556 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1121335004557 active site 1121335004558 motif I; other site 1121335004559 motif II; other site 1121335004560 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335004561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335004562 S-adenosylmethionine binding site [chemical binding]; other site 1121335004563 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1121335004564 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1121335004565 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1121335004566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335004567 ATP binding site [chemical binding]; other site 1121335004568 putative Mg++ binding site [ion binding]; other site 1121335004569 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121335004570 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121335004571 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1121335004572 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1121335004573 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121335004574 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335004575 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335004576 NAD synthetase; Reviewed; Region: nadE; PRK02628 1121335004577 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1121335004578 multimer interface [polypeptide binding]; other site 1121335004579 active site 1121335004580 catalytic triad [active] 1121335004581 protein interface 1 [polypeptide binding]; other site 1121335004582 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1121335004583 homodimer interface [polypeptide binding]; other site 1121335004584 NAD binding pocket [chemical binding]; other site 1121335004585 ATP binding pocket [chemical binding]; other site 1121335004586 Mg binding site [ion binding]; other site 1121335004587 active-site loop [active] 1121335004588 hypothetical protein; Provisional; Region: PRK06851 1121335004589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004590 Walker A motif; other site 1121335004591 ATP binding site [chemical binding]; other site 1121335004592 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004593 active site 1121335004594 NAD binding site [chemical binding]; other site 1121335004595 metal binding site [ion binding]; metal-binding site 1121335004596 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004597 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1121335004598 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335004599 metal ion-dependent adhesion site (MIDAS); other site 1121335004600 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1121335004601 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121335004602 metal ion-dependent adhesion site (MIDAS); other site 1121335004603 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1121335004604 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1121335004605 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335004606 metal ion-dependent adhesion site (MIDAS); other site 1121335004607 Protein of unknown function DUF58; Region: DUF58; pfam01882 1121335004608 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335004609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004610 Walker A motif; other site 1121335004611 ATP binding site [chemical binding]; other site 1121335004612 Walker B motif; other site 1121335004613 arginine finger; other site 1121335004614 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121335004615 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335004616 Walker A/P-loop; other site 1121335004617 ATP binding site [chemical binding]; other site 1121335004618 Q-loop/lid; other site 1121335004619 ABC transporter signature motif; other site 1121335004620 Walker B; other site 1121335004621 D-loop; other site 1121335004622 H-loop/switch region; other site 1121335004623 DNA protecting protein DprA; Region: dprA; TIGR00732 1121335004624 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1121335004625 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1121335004626 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1121335004627 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121335004628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004629 Walker A motif; other site 1121335004630 ATP binding site [chemical binding]; other site 1121335004631 Walker B motif; other site 1121335004632 arginine finger; other site 1121335004633 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1121335004634 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1121335004635 active site 1121335004636 catalytic triad [active] 1121335004637 oxyanion hole [active] 1121335004638 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1121335004639 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1121335004640 Spore germination protein; Region: Spore_permease; cl17796 1121335004641 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1121335004642 (R)-citramalate synthase; Provisional; Region: PRK09389 1121335004643 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1121335004644 active site 1121335004645 catalytic residues [active] 1121335004646 metal binding site [ion binding]; metal-binding site 1121335004647 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1121335004648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121335004649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335004650 active site 1121335004651 phosphorylation site [posttranslational modification] 1121335004652 intermolecular recognition site; other site 1121335004653 dimerization interface [polypeptide binding]; other site 1121335004654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121335004655 DNA binding residues [nucleotide binding] 1121335004656 dimerization interface [polypeptide binding]; other site 1121335004657 Sensor protein DegS; Region: DegS; pfam05384 1121335004658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121335004659 Histidine kinase; Region: HisKA_3; pfam07730 1121335004660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004661 ATP binding site [chemical binding]; other site 1121335004662 Mg2+ binding site [ion binding]; other site 1121335004663 G-X-G motif; other site 1121335004664 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1121335004665 ATP cone domain; Region: ATP-cone; pfam03477 1121335004666 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1121335004667 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1121335004668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004669 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335004670 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004671 DNA binding residues [nucleotide binding] 1121335004672 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1121335004673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004675 DNA binding residues [nucleotide binding] 1121335004676 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1121335004677 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1121335004678 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121335004679 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1121335004680 CAAX protease self-immunity; Region: Abi; pfam02517 1121335004681 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1121335004682 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1121335004683 putative catalytic cysteine [active] 1121335004684 Hemerythrin; Region: Hemerythrin; cd12107 1121335004685 Fe binding site [ion binding]; other site 1121335004686 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1121335004687 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1121335004688 G1 box; other site 1121335004689 putative GEF interaction site [polypeptide binding]; other site 1121335004690 GTP/Mg2+ binding site [chemical binding]; other site 1121335004691 Switch I region; other site 1121335004692 G2 box; other site 1121335004693 G3 box; other site 1121335004694 Switch II region; other site 1121335004695 G4 box; other site 1121335004696 G5 box; other site 1121335004697 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1121335004698 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1121335004699 ACT domain-containing protein [General function prediction only]; Region: COG4747 1121335004700 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 1121335004701 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 1121335004702 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1121335004703 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1121335004704 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1121335004705 NADP-binding site; other site 1121335004706 homotetramer interface [polypeptide binding]; other site 1121335004707 substrate binding site [chemical binding]; other site 1121335004708 homodimer interface [polypeptide binding]; other site 1121335004709 active site 1121335004710 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1121335004711 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1121335004712 NADP binding site [chemical binding]; other site 1121335004713 active site 1121335004714 putative substrate binding site [chemical binding]; other site 1121335004715 DivIVA protein; Region: DivIVA; pfam05103 1121335004716 Phosphotransferase enzyme family; Region: APH; pfam01636 1121335004717 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121335004718 active site 1121335004719 ATP binding site [chemical binding]; other site 1121335004720 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004721 GDP-Fucose binding site [chemical binding]; other site 1121335004722 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004723 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 1121335004724 GDP-Fucose binding site [chemical binding]; other site 1121335004725 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004726 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 1121335004727 GDP-Fucose binding site [chemical binding]; other site 1121335004728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335004729 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121335004730 NAD(P) binding site [chemical binding]; other site 1121335004731 active site 1121335004732 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1121335004733 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1121335004734 alpha subunit interface [polypeptide binding]; other site 1121335004735 TPP binding site [chemical binding]; other site 1121335004736 heterodimer interface [polypeptide binding]; other site 1121335004737 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335004738 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1121335004739 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1121335004740 tetramer interface [polypeptide binding]; other site 1121335004741 TPP-binding site [chemical binding]; other site 1121335004742 heterodimer interface [polypeptide binding]; other site 1121335004743 phosphorylation loop region [posttranslational modification] 1121335004744 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004745 GDP-Fucose binding site [chemical binding]; other site 1121335004746 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1121335004747 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1121335004748 Substrate binding site; other site 1121335004749 Cupin domain; Region: Cupin_2; cl17218 1121335004750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335004751 LexA repressor; Validated; Region: PRK00215 1121335004752 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1121335004753 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121335004754 Catalytic site [active] 1121335004755 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1121335004756 DivIVA protein; Region: DivIVA; pfam05103 1121335004757 YGGT family; Region: YGGT; pfam02325 1121335004758 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1121335004759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1121335004760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335004761 catalytic residue [active] 1121335004762 HlyD family secretion protein; Region: HlyD_2; pfam12700 1121335004763 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1121335004764 Aluminium resistance protein; Region: Alum_res; pfam06838 1121335004765 TPR repeat; Region: TPR_11; pfam13414 1121335004766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004767 binding surface 1121335004768 TPR motif; other site 1121335004769 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335004770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004771 binding surface 1121335004772 TPR motif; other site 1121335004773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335004774 Quinolinate synthetase A protein; Region: NadA; pfam02445 1121335004775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335004776 active site 1121335004777 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121335004778 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1121335004779 putative ligand binding site [chemical binding]; other site 1121335004780 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1121335004781 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335004782 Walker A/P-loop; other site 1121335004783 ATP binding site [chemical binding]; other site 1121335004784 Q-loop/lid; other site 1121335004785 ABC transporter signature motif; other site 1121335004786 Walker B; other site 1121335004787 D-loop; other site 1121335004788 H-loop/switch region; other site 1121335004789 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335004790 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335004791 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121335004792 TM-ABC transporter signature motif; other site 1121335004793 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335004794 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121335004795 TM-ABC transporter signature motif; other site 1121335004796 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121335004797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335004798 RNA binding surface [nucleotide binding]; other site 1121335004799 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121335004800 active site 1121335004801 lipoprotein signal peptidase; Provisional; Region: PRK14787 1121335004802 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1121335004803 Stage II sporulation protein; Region: SpoIID; pfam08486 1121335004804 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1121335004805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335004806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335004807 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121335004808 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1121335004809 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335004810 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335004811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004812 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335004813 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335004814 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1121335004815 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1121335004816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335004817 FeS/SAM binding site; other site 1121335004818 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1121335004819 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1121335004820 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121335004821 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335004822 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1121335004823 nucleotide binding site [chemical binding]; other site 1121335004824 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1121335004825 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1121335004826 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1121335004827 active site 1121335004828 DNA binding site [nucleotide binding] 1121335004829 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1121335004830 DNA binding site [nucleotide binding] 1121335004831 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1121335004832 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1121335004833 putative DNA binding site [nucleotide binding]; other site 1121335004834 putative homodimer interface [polypeptide binding]; other site 1121335004835 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1121335004836 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1121335004837 active site 1121335004838 metal binding site [ion binding]; metal-binding site 1121335004839 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1121335004840 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335004841 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 1121335004842 S-layer homology domain; Region: SLH; pfam00395 1121335004843 S-layer homology domain; Region: SLH; pfam00395 1121335004844 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1121335004845 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1121335004846 intersubunit interface [polypeptide binding]; other site 1121335004847 active site 1121335004848 Zn2+ binding site [ion binding]; other site 1121335004849 ribulokinase; Provisional; Region: PRK04123 1121335004850 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1121335004851 N- and C-terminal domain interface [polypeptide binding]; other site 1121335004852 active site 1121335004853 MgATP binding site [chemical binding]; other site 1121335004854 catalytic site [active] 1121335004855 metal binding site [ion binding]; metal-binding site 1121335004856 carbohydrate binding site [chemical binding]; other site 1121335004857 homodimer interface [polypeptide binding]; other site 1121335004858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335004859 DNA-binding site [nucleotide binding]; DNA binding site 1121335004860 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1121335004861 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1121335004862 putative ligand binding site [chemical binding]; other site 1121335004863 putative dimerization interface [polypeptide binding]; other site 1121335004864 L-arabinose isomerase; Provisional; Region: PRK02929 1121335004865 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1121335004866 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121335004867 trimer interface [polypeptide binding]; other site 1121335004868 putative substrate binding site [chemical binding]; other site 1121335004869 putative metal binding site [ion binding]; other site 1121335004870 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1121335004871 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335004872 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121335004873 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1121335004874 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1121335004875 active site 1121335004876 NTP binding site [chemical binding]; other site 1121335004877 metal binding triad [ion binding]; metal-binding site 1121335004878 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1121335004879 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1121335004880 PQQ-like domain; Region: PQQ_2; pfam13360 1121335004881 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1121335004882 metal binding site [ion binding]; metal-binding site 1121335004883 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335004884 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335004885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004886 dimer interface [polypeptide binding]; other site 1121335004887 conserved gate region; other site 1121335004888 putative PBP binding loops; other site 1121335004889 ABC-ATPase subunit interface; other site 1121335004890 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335004891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004892 dimer interface [polypeptide binding]; other site 1121335004893 conserved gate region; other site 1121335004894 putative PBP binding loops; other site 1121335004895 ABC-ATPase subunit interface; other site 1121335004896 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335004897 Histidine kinase; Region: His_kinase; pfam06580 1121335004898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004899 ATP binding site [chemical binding]; other site 1121335004900 Mg2+ binding site [ion binding]; other site 1121335004901 G-X-G motif; other site 1121335004902 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335004903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335004904 active site 1121335004905 phosphorylation site [posttranslational modification] 1121335004906 intermolecular recognition site; other site 1121335004907 dimerization interface [polypeptide binding]; other site 1121335004908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335004909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004910 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 1121335004911 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335004912 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335004913 dimer interface [polypeptide binding]; other site 1121335004914 putative CheW interface [polypeptide binding]; other site 1121335004915 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1121335004916 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121335004917 ligand binding site [chemical binding]; other site 1121335004918 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121335004919 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121335004920 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121335004921 Transporter associated domain; Region: CorC_HlyC; pfam03471 1121335004922 HEAT repeats; Region: HEAT_2; pfam13646 1121335004923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121335004924 MarR family; Region: MarR_2; pfam12802 1121335004925 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121335004926 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1121335004927 AAA domain; Region: AAA_17; pfam13207 1121335004928 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1121335004929 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1121335004930 active site 1121335004931 catalytic site [active] 1121335004932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335004933 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335004934 putative substrate translocation pore; other site 1121335004935 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1121335004936 active site 1121335004937 metal binding site [ion binding]; metal-binding site 1121335004938 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004939 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1121335004940 Na binding site [ion binding]; other site 1121335004941 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1121335004942 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335004943 RNA binding surface [nucleotide binding]; other site 1121335004944 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1121335004945 active site 1121335004946 metal binding site [ion binding]; metal-binding site 1121335004947 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004948 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335004949 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335004950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004952 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1121335004953 Melibiase; Region: Melibiase; pfam02065 1121335004954 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335004955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004956 dimer interface [polypeptide binding]; other site 1121335004957 conserved gate region; other site 1121335004958 putative PBP binding loops; other site 1121335004959 ABC-ATPase subunit interface; other site 1121335004960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004961 dimer interface [polypeptide binding]; other site 1121335004962 conserved gate region; other site 1121335004963 putative PBP binding loops; other site 1121335004964 ABC-ATPase subunit interface; other site 1121335004965 PBP superfamily domain; Region: PBP_like_2; cl17296 1121335004966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335004967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335004968 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1121335004969 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 1121335004970 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 1121335004971 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1121335004972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335004973 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1121335004974 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 1121335004975 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1121335004976 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 1121335004977 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1121335004978 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 1121335004979 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 1121335004980 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1121335004981 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1121335004982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335004983 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121335004984 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1121335004985 active site residue [active] 1121335004986 Repair protein; Region: Repair_PSII; pfam04536 1121335004987 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1121335004988 MgtC family; Region: MgtC; pfam02308 1121335004989 LemA family; Region: LemA; cl00742 1121335004990 LemA family; Region: LemA; cl00742 1121335004991 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121335004992 catalytic triad [active] 1121335004993 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1121335004994 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1121335004995 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1121335004996 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1121335004997 acyl-activating enzyme (AAE) consensus motif; other site 1121335004998 AMP binding site [chemical binding]; other site 1121335004999 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1121335005000 aspartate racemase; Region: asp_race; TIGR00035 1121335005001 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121335005002 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335005003 ribonuclease Z; Region: RNase_Z; TIGR02651 1121335005004 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1121335005005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335005006 flavoprotein, HI0933 family; Region: TIGR00275 1121335005007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335005008 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121335005009 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1121335005010 acyl-activating enzyme (AAE) consensus motif; other site 1121335005011 AMP binding site [chemical binding]; other site 1121335005012 active site 1121335005013 CoA binding site [chemical binding]; other site 1121335005014 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1121335005015 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1121335005016 active site 1121335005017 HIGH motif; other site 1121335005018 dimer interface [polypeptide binding]; other site 1121335005019 KMSKS motif; other site 1121335005020 DNA polymerase IV; Reviewed; Region: PRK03103 1121335005021 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121335005022 active site 1121335005023 DNA binding site [nucleotide binding] 1121335005024 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1121335005025 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 1121335005026 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1121335005027 CRISPR-associated endoribonuclease Cas6; Region: cas_cas6; TIGR01877 1121335005028 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1121335005029 putative efflux protein, MATE family; Region: matE; TIGR00797 1121335005030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335005031 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005032 dimerization interface [polypeptide binding]; other site 1121335005033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335005034 dimer interface [polypeptide binding]; other site 1121335005035 phosphorylation site [posttranslational modification] 1121335005036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005037 ATP binding site [chemical binding]; other site 1121335005038 Mg2+ binding site [ion binding]; other site 1121335005039 G-X-G motif; other site 1121335005040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335005041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005042 active site 1121335005043 phosphorylation site [posttranslational modification] 1121335005044 intermolecular recognition site; other site 1121335005045 dimerization interface [polypeptide binding]; other site 1121335005046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335005047 DNA binding site [nucleotide binding] 1121335005048 thioredoxin 2; Provisional; Region: PRK10996 1121335005049 putative phosphate acyltransferase; Provisional; Region: PRK05331 1121335005050 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1121335005051 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1121335005052 active site 1121335005053 Zn binding site [ion binding]; other site 1121335005054 alpha-galactosidase; Region: PLN02808; cl17638 1121335005055 Cache domain; Region: Cache_1; pfam02743 1121335005056 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121335005057 HAMP domain; Region: HAMP; pfam00672 1121335005058 dimerization interface [polypeptide binding]; other site 1121335005059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005060 dimer interface [polypeptide binding]; other site 1121335005061 putative CheW interface [polypeptide binding]; other site 1121335005062 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1121335005063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335005064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005065 homodimer interface [polypeptide binding]; other site 1121335005066 catalytic residue [active] 1121335005067 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121335005068 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121335005069 Walker A/P-loop; other site 1121335005070 ATP binding site [chemical binding]; other site 1121335005071 Q-loop/lid; other site 1121335005072 ABC transporter signature motif; other site 1121335005073 Walker B; other site 1121335005074 D-loop; other site 1121335005075 H-loop/switch region; other site 1121335005076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121335005077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005078 dimer interface [polypeptide binding]; other site 1121335005079 conserved gate region; other site 1121335005080 putative PBP binding loops; other site 1121335005081 ABC-ATPase subunit interface; other site 1121335005082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335005083 hinge residues; other site 1121335005084 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121335005085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335005086 substrate binding pocket [chemical binding]; other site 1121335005087 membrane-bound complex binding site; other site 1121335005088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005089 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335005090 active site 1121335005091 phosphorylation site [posttranslational modification] 1121335005092 intermolecular recognition site; other site 1121335005093 dimerization interface [polypeptide binding]; other site 1121335005094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335005095 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335005096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335005097 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335005098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005099 dimerization interface [polypeptide binding]; other site 1121335005100 Histidine kinase; Region: His_kinase; pfam06580 1121335005101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005102 ATP binding site [chemical binding]; other site 1121335005103 Mg2+ binding site [ion binding]; other site 1121335005104 G-X-G motif; other site 1121335005105 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335005106 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335005107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005108 dimer interface [polypeptide binding]; other site 1121335005109 conserved gate region; other site 1121335005110 putative PBP binding loops; other site 1121335005111 ABC-ATPase subunit interface; other site 1121335005112 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335005113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005114 dimer interface [polypeptide binding]; other site 1121335005115 conserved gate region; other site 1121335005116 putative PBP binding loops; other site 1121335005117 ABC-ATPase subunit interface; other site 1121335005118 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335005119 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335005120 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1121335005121 Walker A/P-loop; other site 1121335005122 ATP binding site [chemical binding]; other site 1121335005123 Q-loop/lid; other site 1121335005124 ABC transporter signature motif; other site 1121335005125 Walker B; other site 1121335005126 D-loop; other site 1121335005127 H-loop/switch region; other site 1121335005128 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1121335005129 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1121335005130 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1121335005131 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1121335005132 dimer interface [polypeptide binding]; other site 1121335005133 substrate binding site [chemical binding]; other site 1121335005134 metal binding sites [ion binding]; metal-binding site 1121335005135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335005136 MULE transposase domain; Region: MULE; pfam10551 1121335005137 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1121335005138 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005139 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005140 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005141 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005142 S-layer homology domain; Region: SLH; pfam00395 1121335005143 S-layer homology domain; Region: SLH; pfam00395 1121335005144 S-layer homology domain; Region: SLH; pfam00395 1121335005145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005146 dimerization interface [polypeptide binding]; other site 1121335005147 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005149 dimer interface [polypeptide binding]; other site 1121335005150 putative CheW interface [polypeptide binding]; other site 1121335005151 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 1121335005152 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335005153 active site 1121335005154 HIGH motif; other site 1121335005155 nucleotide binding site [chemical binding]; other site 1121335005156 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335005157 KMSKS motif; other site 1121335005158 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121335005159 tRNA binding surface [nucleotide binding]; other site 1121335005160 anticodon binding site; other site 1121335005161 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1121335005162 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121335005163 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121335005164 active site 1121335005165 dimer interface [polypeptide binding]; other site 1121335005166 motif 1; other site 1121335005167 motif 2; other site 1121335005168 motif 3; other site 1121335005169 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121335005170 anticodon binding site; other site 1121335005171 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1121335005172 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1121335005173 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1121335005174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335005175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335005176 DNA binding residues [nucleotide binding] 1121335005177 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1121335005178 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1121335005179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335005180 Walker A/P-loop; other site 1121335005181 ATP binding site [chemical binding]; other site 1121335005182 Q-loop/lid; other site 1121335005183 ABC transporter signature motif; other site 1121335005184 Walker B; other site 1121335005185 D-loop; other site 1121335005186 H-loop/switch region; other site 1121335005187 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121335005188 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121335005189 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1121335005190 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1121335005191 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1121335005192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335005193 putative substrate translocation pore; other site 1121335005194 S-layer homology domain; Region: SLH; pfam00395 1121335005195 S-layer homology domain; Region: SLH; pfam00395 1121335005196 S-layer homology domain; Region: SLH; pfam00395 1121335005197 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1121335005198 active site 1121335005199 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1121335005200 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1121335005201 Rubredoxin [Energy production and conversion]; Region: COG1773 1121335005202 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 1121335005203 iron binding site [ion binding]; other site 1121335005204 Rubrerythrin [Energy production and conversion]; Region: COG1592 1121335005205 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1121335005206 binuclear metal center [ion binding]; other site 1121335005207 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1121335005208 iron binding site [ion binding]; other site 1121335005209 Cupin domain; Region: Cupin_2; cl17218 1121335005210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335005211 binding surface 1121335005212 TPR motif; other site 1121335005213 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1121335005214 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121335005215 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121335005216 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121335005217 catalytic residue [active] 1121335005218 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1121335005219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335005220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335005221 DNA binding residues [nucleotide binding] 1121335005222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335005223 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121335005224 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121335005225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121335005226 putative acyl-acceptor binding pocket; other site 1121335005227 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1121335005228 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1121335005229 NAD binding site [chemical binding]; other site 1121335005230 ligand binding site [chemical binding]; other site 1121335005231 catalytic site [active] 1121335005232 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121335005233 transmembrane helices; other site 1121335005234 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1121335005235 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121335005236 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1121335005237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335005238 putative substrate translocation pore; other site 1121335005239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335005240 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121335005241 Predicted flavoprotein [General function prediction only]; Region: COG0431 1121335005242 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335005243 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335005244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335005245 Walker A/P-loop; other site 1121335005246 ATP binding site [chemical binding]; other site 1121335005247 Q-loop/lid; other site 1121335005248 ABC transporter signature motif; other site 1121335005249 Walker B; other site 1121335005250 D-loop; other site 1121335005251 H-loop/switch region; other site 1121335005252 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335005253 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335005254 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335005255 Walker A/P-loop; other site 1121335005256 ATP binding site [chemical binding]; other site 1121335005257 Q-loop/lid; other site 1121335005258 ABC transporter signature motif; other site 1121335005259 Walker B; other site 1121335005260 D-loop; other site 1121335005261 H-loop/switch region; other site 1121335005262 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121335005263 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1121335005264 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121335005265 FeoA domain; Region: FeoA; pfam04023 1121335005266 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1121335005267 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121335005268 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121335005269 G1 box; other site 1121335005270 GTP/Mg2+ binding site [chemical binding]; other site 1121335005271 Switch I region; other site 1121335005272 G2 box; other site 1121335005273 G3 box; other site 1121335005274 Switch II region; other site 1121335005275 G4 box; other site 1121335005276 G5 box; other site 1121335005277 Nucleoside recognition; Region: Gate; pfam07670 1121335005278 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121335005279 Nucleoside recognition; Region: Gate; pfam07670 1121335005280 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1121335005281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335005282 NAD(P) binding site [chemical binding]; other site 1121335005283 active site 1121335005284 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1121335005285 putative deacylase active site [active] 1121335005286 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1121335005287 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1121335005288 Cache domain; Region: Cache_1; pfam02743 1121335005289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005290 dimerization interface [polypeptide binding]; other site 1121335005291 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005293 dimer interface [polypeptide binding]; other site 1121335005294 putative CheW interface [polypeptide binding]; other site 1121335005295 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1121335005296 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1121335005297 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1121335005298 putative metal binding residues [ion binding]; other site 1121335005299 signature motif; other site 1121335005300 dimer interface [polypeptide binding]; other site 1121335005301 active site 1121335005302 polyP binding site; other site 1121335005303 substrate binding site [chemical binding]; other site 1121335005304 acceptor-phosphate pocket; other site 1121335005305 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1121335005306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005307 active site 1121335005308 phosphorylation site [posttranslational modification] 1121335005309 intermolecular recognition site; other site 1121335005310 dimerization interface [polypeptide binding]; other site 1121335005311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335005312 DNA binding site [nucleotide binding] 1121335005313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335005314 dimer interface [polypeptide binding]; other site 1121335005315 phosphorylation site [posttranslational modification] 1121335005316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005317 ATP binding site [chemical binding]; other site 1121335005318 Mg2+ binding site [ion binding]; other site 1121335005319 G-X-G motif; other site 1121335005320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005321 dimerization interface [polypeptide binding]; other site 1121335005322 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005323 dimer interface [polypeptide binding]; other site 1121335005324 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1121335005325 putative CheW interface [polypeptide binding]; other site 1121335005326 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121335005327 putative CheA interaction surface; other site 1121335005328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335005329 non-specific DNA binding site [nucleotide binding]; other site 1121335005330 salt bridge; other site 1121335005331 sequence-specific DNA binding site [nucleotide binding]; other site 1121335005332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335005333 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335005334 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1121335005335 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1121335005336 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121335005337 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121335005338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005339 active site 1121335005340 phosphorylation site [posttranslational modification] 1121335005341 intermolecular recognition site; other site 1121335005342 dimerization interface [polypeptide binding]; other site 1121335005343 CheB methylesterase; Region: CheB_methylest; pfam01339 1121335005344 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121335005345 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121335005346 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121335005347 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121335005348 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121335005349 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121335005350 putative binding surface; other site 1121335005351 active site 1121335005352 P2 response regulator binding domain; Region: P2; pfam07194 1121335005353 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121335005354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005355 ATP binding site [chemical binding]; other site 1121335005356 Mg2+ binding site [ion binding]; other site 1121335005357 G-X-G motif; other site 1121335005358 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121335005359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335005360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335005361 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121335005362 active site 1121335005363 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1121335005364 dimer interface [polypeptide binding]; other site 1121335005365 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121335005366 Ligand Binding Site [chemical binding]; other site 1121335005367 Molecular Tunnel; other site 1121335005368 CTP synthetase; Validated; Region: pyrG; PRK05380 1121335005369 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1121335005370 Catalytic site [active] 1121335005371 active site 1121335005372 UTP binding site [chemical binding]; other site 1121335005373 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1121335005374 active site 1121335005375 putative oxyanion hole; other site 1121335005376 catalytic triad [active] 1121335005377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005378 phosphorylation site [posttranslational modification] 1121335005379 intermolecular recognition site; other site 1121335005380 ANTAR domain; Region: ANTAR; pfam03861 1121335005381 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335005382 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1121335005383 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335005384 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121335005385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335005386 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335005387 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121335005388 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1121335005389 domain_subunit interface; other site 1121335005390 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121335005391 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1121335005392 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1121335005393 active site 1121335005394 FMN binding site [chemical binding]; other site 1121335005395 substrate binding site [chemical binding]; other site 1121335005396 3Fe-4S cluster binding site [ion binding]; other site 1121335005397 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1121335005398 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1121335005399 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1121335005400 putative active site [active] 1121335005401 asparagine synthetase AsnA; Provisional; Region: PRK05425 1121335005402 motif 1; other site 1121335005403 dimer interface [polypeptide binding]; other site 1121335005404 active site 1121335005405 motif 2; other site 1121335005406 motif 3; other site 1121335005407 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121335005408 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121335005409 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335005410 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1121335005411 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1121335005412 GDP-binding site [chemical binding]; other site 1121335005413 ACT binding site; other site 1121335005414 IMP binding site; other site 1121335005415 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121335005416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005417 active site 1121335005418 phosphorylation site [posttranslational modification] 1121335005419 intermolecular recognition site; other site 1121335005420 dimerization interface [polypeptide binding]; other site 1121335005421 CheB methylesterase; Region: CheB_methylest; pfam01339 1121335005422 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121335005423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005424 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121335005425 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005426 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005427 dimer interface [polypeptide binding]; other site 1121335005428 putative CheW interface [polypeptide binding]; other site 1121335005429 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005431 dimer interface [polypeptide binding]; other site 1121335005432 putative CheW interface [polypeptide binding]; other site 1121335005433 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005434 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005436 dimer interface [polypeptide binding]; other site 1121335005437 putative CheW interface [polypeptide binding]; other site 1121335005438 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005439 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121335005440 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121335005441 putative binding surface; other site 1121335005442 active site 1121335005443 P2 response regulator binding domain; Region: P2; pfam07194 1121335005444 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121335005445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005446 ATP binding site [chemical binding]; other site 1121335005447 Mg2+ binding site [ion binding]; other site 1121335005448 G-X-G motif; other site 1121335005449 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121335005450 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121335005451 putative CheA interaction surface; other site 1121335005452 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335005453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005454 active site 1121335005455 phosphorylation site [posttranslational modification] 1121335005456 intermolecular recognition site; other site 1121335005457 dimerization interface [polypeptide binding]; other site 1121335005458 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335005459 active site 1121335005460 DNA binding site [nucleotide binding] 1121335005461 Int/Topo IB signature motif; other site 1121335005462 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1121335005463 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1121335005464 dimer interface [polypeptide binding]; other site 1121335005465 active site 1121335005466 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335005467 catalytic residues [active] 1121335005468 substrate binding site [chemical binding]; other site 1121335005469 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1121335005470 agmatinase; Region: agmatinase; TIGR01230 1121335005471 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1121335005472 putative active site [active] 1121335005473 Mn binding site [ion binding]; other site 1121335005474 spermidine synthase; Provisional; Region: PRK00811 1121335005475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005476 S-adenosylmethionine binding site [chemical binding]; other site 1121335005477 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1121335005478 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121335005479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335005480 catalytic residue [active] 1121335005481 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1121335005482 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1121335005483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121335005484 S-layer homology domain; Region: SLH; pfam00395 1121335005485 Protein of unknown function DUF91; Region: DUF91; cl00709 1121335005486 MULE transposase domain; Region: MULE; pfam10551 1121335005487 MULE transposase domain; Region: MULE; pfam10551 1121335005488 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 1121335005489 PLD-like domain; Region: PLDc_2; pfam13091 1121335005490 putative active site [active] 1121335005491 catalytic site [active] 1121335005492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335005493 ATP binding site [chemical binding]; other site 1121335005494 putative Mg++ binding site [ion binding]; other site 1121335005495 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1121335005496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335005497 nucleotide binding region [chemical binding]; other site 1121335005498 ATP-binding site [chemical binding]; other site 1121335005499 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1121335005500 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1121335005501 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121335005502 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 1121335005503 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1121335005504 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335005505 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121335005506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335005507 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335005508 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335005509 MULE transposase domain; Region: MULE; pfam10551 1121335005510 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1121335005511 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1121335005512 glutaminase active site [active] 1121335005513 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1121335005514 dimer interface [polypeptide binding]; other site 1121335005515 active site 1121335005516 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1121335005517 dimer interface [polypeptide binding]; other site 1121335005518 active site 1121335005519 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335005520 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1121335005521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335005522 MULE transposase domain; Region: MULE; pfam10551 1121335005523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121335005524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121335005525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121335005526 dimerization interface [polypeptide binding]; other site 1121335005527 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1121335005528 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1121335005529 Cache domain; Region: Cache_1; pfam02743 1121335005530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005531 dimerization interface [polypeptide binding]; other site 1121335005532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005533 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005535 dimer interface [polypeptide binding]; other site 1121335005536 putative CheW interface [polypeptide binding]; other site 1121335005537 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335005538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335005539 metal binding site [ion binding]; metal-binding site 1121335005540 active site 1121335005541 I-site; other site 1121335005542 PAS domain S-box; Region: sensory_box; TIGR00229 1121335005543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335005544 putative active site [active] 1121335005545 heme pocket [chemical binding]; other site 1121335005546 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1121335005547 Protein of unknown function (DUF511); Region: DUF511; pfam04373 1121335005548 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1121335005549 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1121335005550 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1121335005551 putative active site [active] 1121335005552 oxyanion strand; other site 1121335005553 catalytic triad [active] 1121335005554 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121335005555 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121335005556 substrate binding site [chemical binding]; other site 1121335005557 glutamase interaction surface [polypeptide binding]; other site 1121335005558 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1121335005559 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1121335005560 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121335005561 dimer interface [polypeptide binding]; other site 1121335005562 substrate binding site [chemical binding]; other site 1121335005563 ATP binding site [chemical binding]; other site 1121335005564 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121335005565 dimer interface [polypeptide binding]; other site 1121335005566 substrate binding site [chemical binding]; other site 1121335005567 ATP binding site [chemical binding]; other site 1121335005568 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335005569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335005570 motif II; other site 1121335005571 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1121335005572 thiamine phosphate binding site [chemical binding]; other site 1121335005573 active site 1121335005574 pyrophosphate binding site [ion binding]; other site 1121335005575 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1121335005576 substrate binding site [chemical binding]; other site 1121335005577 multimerization interface [polypeptide binding]; other site 1121335005578 ATP binding site [chemical binding]; other site 1121335005579 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1121335005580 PUA domain; Region: PUA; cl00607 1121335005581 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1121335005582 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1121335005583 putative RNA binding site [nucleotide binding]; other site 1121335005584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005585 S-adenosylmethionine binding site [chemical binding]; other site 1121335005586 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1121335005587 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335005588 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121335005589 HAMP domain; Region: HAMP; pfam00672 1121335005590 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005591 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005592 dimer interface [polypeptide binding]; other site 1121335005593 putative CheW interface [polypeptide binding]; other site 1121335005594 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121335005595 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1121335005596 ArsC family; Region: ArsC; pfam03960 1121335005597 putative ArsC-like catalytic residues; other site 1121335005598 putative TRX-like catalytic residues [active] 1121335005599 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1121335005600 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1121335005601 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335005602 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1121335005603 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121335005604 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1121335005605 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1121335005606 diiron binding motif [ion binding]; other site 1121335005607 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 1121335005608 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1121335005609 Predicted membrane protein [Function unknown]; Region: COG1511 1121335005610 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1121335005611 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1121335005612 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121335005613 active site 1121335005614 catalytic site [active] 1121335005615 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 1121335005616 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1121335005617 carbohydrate binding site [chemical binding]; other site 1121335005618 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1121335005619 carbohydrate binding site [chemical binding]; other site 1121335005620 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1121335005621 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1121335005622 Ca binding site [ion binding]; other site 1121335005623 active site 1121335005624 catalytic site [active] 1121335005625 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1121335005626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005627 S-adenosylmethionine binding site [chemical binding]; other site 1121335005628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005629 S-adenosylmethionine binding site [chemical binding]; other site 1121335005630 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1121335005631 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121335005632 intersubunit interface [polypeptide binding]; other site 1121335005633 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1121335005634 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121335005635 Walker A/P-loop; other site 1121335005636 ATP binding site [chemical binding]; other site 1121335005637 Q-loop/lid; other site 1121335005638 ABC transporter signature motif; other site 1121335005639 Walker B; other site 1121335005640 D-loop; other site 1121335005641 H-loop/switch region; other site 1121335005642 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121335005643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335005644 ABC-ATPase subunit interface; other site 1121335005645 dimer interface [polypeptide binding]; other site 1121335005646 putative PBP binding regions; other site 1121335005647 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335005648 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121335005649 ABC-ATPase subunit interface; other site 1121335005650 dimer interface [polypeptide binding]; other site 1121335005651 putative PBP binding regions; other site 1121335005652 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335005653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335005654 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1121335005655 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121335005656 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121335005657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1121335005658 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1121335005659 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1121335005660 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121335005661 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121335005662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005663 dimer interface [polypeptide binding]; other site 1121335005664 conserved gate region; other site 1121335005665 putative PBP binding loops; other site 1121335005666 ABC-ATPase subunit interface; other site 1121335005667 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121335005668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005669 dimer interface [polypeptide binding]; other site 1121335005670 conserved gate region; other site 1121335005671 putative PBP binding loops; other site 1121335005672 ABC-ATPase subunit interface; other site 1121335005673 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121335005674 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121335005675 Walker A/P-loop; other site 1121335005676 ATP binding site [chemical binding]; other site 1121335005677 Q-loop/lid; other site 1121335005678 ABC transporter signature motif; other site 1121335005679 Walker B; other site 1121335005680 D-loop; other site 1121335005681 H-loop/switch region; other site 1121335005682 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1121335005683 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121335005684 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121335005685 MarR family; Region: MarR_2; cl17246 1121335005686 MarR family; Region: MarR_2; cl17246 1121335005687 FeoA domain; Region: FeoA; pfam04023 1121335005688 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121335005689 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121335005690 G1 box; other site 1121335005691 GTP/Mg2+ binding site [chemical binding]; other site 1121335005692 Switch I region; other site 1121335005693 G2 box; other site 1121335005694 G3 box; other site 1121335005695 Switch II region; other site 1121335005696 G4 box; other site 1121335005697 G5 box; other site 1121335005698 Nucleoside recognition; Region: Gate; pfam07670 1121335005699 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121335005700 Nucleoside recognition; Region: Gate; pfam07670 1121335005701 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335005702 NPCBM/NEW2 domain; Region: NPCBM; cl07060 1121335005703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1121335005704 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335005705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335005706 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 1121335005707 4Fe-4S binding domain; Region: Fer4; cl02805 1121335005708 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335005709 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335005710 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1121335005711 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1121335005712 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335005713 Putative Fe-S cluster; Region: FeS; cl17515 1121335005714 PAS fold; Region: PAS; pfam00989 1121335005715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335005716 putative active site [active] 1121335005717 heme pocket [chemical binding]; other site 1121335005718 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335005719 dimer interface [polypeptide binding]; other site 1121335005720 [2Fe-2S] cluster binding site [ion binding]; other site 1121335005721 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335005722 dimer interface [polypeptide binding]; other site 1121335005723 [2Fe-2S] cluster binding site [ion binding]; other site 1121335005724 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1121335005725 active site 1121335005726 substrate binding site [chemical binding]; other site 1121335005727 Phosphotransferase enzyme family; Region: APH; pfam01636 1121335005728 ATP binding site [chemical binding]; other site 1121335005729 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1121335005730 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1121335005731 putative catalytic cysteine [active] 1121335005732 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1121335005733 putative active site [active] 1121335005734 metal binding site [ion binding]; metal-binding site 1121335005735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121335005736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121335005737 Cache domain; Region: Cache_1; pfam02743 1121335005738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005739 dimerization interface [polypeptide binding]; other site 1121335005740 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005741 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005742 dimer interface [polypeptide binding]; other site 1121335005743 putative CheW interface [polypeptide binding]; other site 1121335005744 conserved hypothetical integral membrane protein; Region: TIGR03766 1121335005745 Flavin Reductases; Region: FlaRed; cl00801 1121335005746 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1121335005747 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 1121335005748 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 1121335005749 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1121335005750 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 1121335005751 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1121335005752 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1121335005753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335005754 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1121335005755 endoglucanase; Region: PLN02420 1121335005756 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 1121335005757 Cellulose binding domain; Region: CBM_3; pfam00942 1121335005758 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1121335005759 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1121335005760 Cellulose binding domain; Region: CBM_3; pfam00942 1121335005761 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 1121335005762 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1121335005763 Cellulose binding domain; Region: CBM_3; pfam00942 1121335005764 Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998 1121335005765 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1121335005766 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1121335005767 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1121335005768 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1121335005769 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1121335005770 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1121335005771 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1121335005772 putative dimer interface [polypeptide binding]; other site 1121335005773 catalytic triad [active] 1121335005774 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335005775 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1121335005776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335005777 motif II; other site 1121335005778 FtsH Extracellular; Region: FtsH_ext; pfam06480 1121335005779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335005780 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121335005781 Walker A motif; other site 1121335005782 ATP binding site [chemical binding]; other site 1121335005783 Walker B motif; other site 1121335005784 arginine finger; other site 1121335005785 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335005786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335005787 FeS/SAM binding site; other site 1121335005788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335005789 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335005790 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121335005791 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121335005792 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335005793 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1121335005794 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1121335005795 GatB domain; Region: GatB_Yqey; smart00845 1121335005796 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121335005797 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1121335005798 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1121335005799 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121335005800 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121335005801 dimer interface [polypeptide binding]; other site 1121335005802 anticodon binding site; other site 1121335005803 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121335005804 homodimer interface [polypeptide binding]; other site 1121335005805 motif 1; other site 1121335005806 active site 1121335005807 motif 2; other site 1121335005808 GAD domain; Region: GAD; pfam02938 1121335005809 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335005810 active site 1121335005811 motif 3; other site 1121335005812 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1121335005813 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121335005814 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1121335005815 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335005816 metal binding site [ion binding]; metal-binding site 1121335005817 ligand binding site [chemical binding]; other site 1121335005818 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335005819 metal binding site [ion binding]; metal-binding site 1121335005820 ligand binding site [chemical binding]; other site 1121335005821 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335005822 metal binding site [ion binding]; metal-binding site 1121335005823 ligand binding site [chemical binding]; other site 1121335005824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121335005825 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 1121335005826 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 1121335005827 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 1121335005828 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121335005829 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121335005830 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335005831 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335005832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335005833 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121335005834 Coenzyme A binding pocket [chemical binding]; other site 1121335005835 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1121335005836 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1121335005837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121335005838 HTH-like domain; Region: HTH_21; pfam13276 1121335005839 Integrase core domain; Region: rve; pfam00665 1121335005840 Integrase core domain; Region: rve_3; pfam13683 1121335005841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335005842 MULE transposase domain; Region: MULE; pfam10551 1121335005843 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121335005844 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1121335005845 catalytic residues [active] 1121335005846 catalytic nucleophile [active] 1121335005847 Recombinase; Region: Recombinase; pfam07508 1121335005848 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1121335005849 TRAM domain; Region: TRAM; cl01282 1121335005850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005851 S-adenosylmethionine binding site [chemical binding]; other site 1121335005852 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335005853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335005854 non-specific DNA binding site [nucleotide binding]; other site 1121335005855 salt bridge; other site 1121335005856 sequence-specific DNA binding site [nucleotide binding]; other site 1121335005857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005858 active site 1121335005859 phosphorylation site [posttranslational modification] 1121335005860 intermolecular recognition site; other site 1121335005861 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1121335005862 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335005863 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335005864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005865 S-adenosylmethionine binding site [chemical binding]; other site 1121335005866 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335005867 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335005868 Walker A/P-loop; other site 1121335005869 ATP binding site [chemical binding]; other site 1121335005870 Q-loop/lid; other site 1121335005871 ABC transporter signature motif; other site 1121335005872 Walker B; other site 1121335005873 D-loop; other site 1121335005874 H-loop/switch region; other site 1121335005875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335005876 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335005877 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335005878 NMT1-like family; Region: NMT1_2; pfam13379 1121335005879 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335005880 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 1121335005881 ACS interaction site; other site 1121335005882 CODH interaction site; other site 1121335005883 metal cluster binding site [ion binding]; other site 1121335005884 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121335005885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335005886 Coenzyme A binding pocket [chemical binding]; other site 1121335005887 YibE/F-like protein; Region: YibE_F; pfam07907 1121335005888 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1121335005889 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121335005890 dimer interface [polypeptide binding]; other site 1121335005891 active site 1121335005892 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121335005893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335005894 HAMP domain; Region: HAMP; pfam00672 1121335005895 dimerization interface [polypeptide binding]; other site 1121335005896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335005897 dimer interface [polypeptide binding]; other site 1121335005898 phosphorylation site [posttranslational modification] 1121335005899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005900 ATP binding site [chemical binding]; other site 1121335005901 Mg2+ binding site [ion binding]; other site 1121335005902 G-X-G motif; other site 1121335005903 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121335005904 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121335005905 dimer interface [polypeptide binding]; other site 1121335005906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005907 catalytic residue [active] 1121335005908 Predicted transcriptional regulator [Transcription]; Region: COG1959 1121335005909 Transcriptional regulator; Region: Rrf2; cl17282 1121335005910 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1121335005911 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121335005912 homodimer interface [polypeptide binding]; other site 1121335005913 substrate-cofactor binding pocket; other site 1121335005914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005915 catalytic residue [active] 1121335005916 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1121335005917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335005918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005919 homodimer interface [polypeptide binding]; other site 1121335005920 catalytic residue [active] 1121335005921 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1121335005922 peptidase T-like protein; Region: PepT-like; TIGR01883 1121335005923 metal binding site [ion binding]; metal-binding site 1121335005924 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1121335005925 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121335005926 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1121335005927 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121335005928 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1121335005929 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 1121335005930 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335005931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335005932 FeS/SAM binding site; other site 1121335005933 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1121335005934 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121335005935 homodimer interface [polypeptide binding]; other site 1121335005936 substrate-cofactor binding pocket; other site 1121335005937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005938 catalytic residue [active] 1121335005939 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335005940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335005941 substrate binding pocket [chemical binding]; other site 1121335005942 membrane-bound complex binding site; other site 1121335005943 hinge residues; other site 1121335005944 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335005945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005946 dimer interface [polypeptide binding]; other site 1121335005947 conserved gate region; other site 1121335005948 putative PBP binding loops; other site 1121335005949 ABC-ATPase subunit interface; other site 1121335005950 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335005951 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335005952 Walker A/P-loop; other site 1121335005953 ATP binding site [chemical binding]; other site 1121335005954 Q-loop/lid; other site 1121335005955 ABC transporter signature motif; other site 1121335005956 Walker B; other site 1121335005957 D-loop; other site 1121335005958 H-loop/switch region; other site 1121335005959 nitrogenase iron protein; Region: nifH; TIGR01287 1121335005960 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1121335005961 Nucleotide-binding sites [chemical binding]; other site 1121335005962 Walker A motif; other site 1121335005963 Switch I region of nucleotide binding site; other site 1121335005964 Fe4S4 binding sites [ion binding]; other site 1121335005965 Switch II region of nucleotide binding site; other site 1121335005966 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335005967 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121335005968 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121335005969 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1121335005970 active site 1121335005971 trimer interface [polypeptide binding]; other site 1121335005972 allosteric site; other site 1121335005973 active site lid [active] 1121335005974 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1121335005975 MgtE intracellular N domain; Region: MgtE_N; smart00924 1121335005976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1121335005977 Divalent cation transporter; Region: MgtE; pfam01769 1121335005978 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121335005979 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121335005980 G1 box; other site 1121335005981 GTP/Mg2+ binding site [chemical binding]; other site 1121335005982 Switch I region; other site 1121335005983 G2 box; other site 1121335005984 G3 box; other site 1121335005985 Switch II region; other site 1121335005986 G4 box; other site 1121335005987 G5 box; other site 1121335005988 Nucleoside recognition; Region: Gate; pfam07670 1121335005989 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121335005990 Nucleoside recognition; Region: Gate; pfam07670 1121335005991 FeoA domain; Region: FeoA; pfam04023 1121335005992 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1121335005993 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121335005994 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121335005995 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1121335005996 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1121335005997 G1 box; other site 1121335005998 putative GEF interaction site [polypeptide binding]; other site 1121335005999 GTP/Mg2+ binding site [chemical binding]; other site 1121335006000 Switch I region; other site 1121335006001 G2 box; other site 1121335006002 G3 box; other site 1121335006003 Switch II region; other site 1121335006004 G4 box; other site 1121335006005 G5 box; other site 1121335006006 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1121335006007 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1121335006008 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1121335006009 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1121335006010 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1121335006011 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1121335006012 active site 1121335006013 dimer interface [polypeptide binding]; other site 1121335006014 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121335006015 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121335006016 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1121335006017 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1121335006018 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1121335006019 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121335006020 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121335006021 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1121335006022 GTP-binding protein Der; Reviewed; Region: PRK00093 1121335006023 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1121335006024 G1 box; other site 1121335006025 GTP/Mg2+ binding site [chemical binding]; other site 1121335006026 Switch I region; other site 1121335006027 G2 box; other site 1121335006028 Switch II region; other site 1121335006029 G3 box; other site 1121335006030 G4 box; other site 1121335006031 G5 box; other site 1121335006032 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1121335006033 G1 box; other site 1121335006034 GTP/Mg2+ binding site [chemical binding]; other site 1121335006035 Switch I region; other site 1121335006036 G2 box; other site 1121335006037 G3 box; other site 1121335006038 Switch II region; other site 1121335006039 G4 box; other site 1121335006040 G5 box; other site 1121335006041 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1121335006042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1121335006043 active site 1121335006044 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335006045 substrate binding site [chemical binding]; other site 1121335006046 catalytic residues [active] 1121335006047 dimer interface [polypeptide binding]; other site 1121335006048 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1121335006049 core dimer interface [polypeptide binding]; other site 1121335006050 peripheral dimer interface [polypeptide binding]; other site 1121335006051 L10 interface [polypeptide binding]; other site 1121335006052 L11 interface [polypeptide binding]; other site 1121335006053 putative EF-Tu interaction site [polypeptide binding]; other site 1121335006054 putative EF-G interaction site [polypeptide binding]; other site 1121335006055 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1121335006056 23S rRNA interface [nucleotide binding]; other site 1121335006057 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1121335006058 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1121335006059 mRNA/rRNA interface [nucleotide binding]; other site 1121335006060 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1121335006061 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1121335006062 23S rRNA interface [nucleotide binding]; other site 1121335006063 L7/L12 interface [polypeptide binding]; other site 1121335006064 putative thiostrepton binding site; other site 1121335006065 L25 interface [polypeptide binding]; other site 1121335006066 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1121335006067 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1121335006068 putative homodimer interface [polypeptide binding]; other site 1121335006069 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121335006070 heterodimer interface [polypeptide binding]; other site 1121335006071 homodimer interface [polypeptide binding]; other site 1121335006072 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1121335006073 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1121335006074 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1121335006075 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1121335006076 substrate binding site [chemical binding]; other site 1121335006077 active site 1121335006078 catalytic residues [active] 1121335006079 heterodimer interface [polypeptide binding]; other site 1121335006080 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1121335006081 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1121335006082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335006083 catalytic residue [active] 1121335006084 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1121335006085 active site 1121335006086 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1121335006087 active site 1121335006088 ribulose/triose binding site [chemical binding]; other site 1121335006089 phosphate binding site [ion binding]; other site 1121335006090 substrate (anthranilate) binding pocket [chemical binding]; other site 1121335006091 product (indole) binding pocket [chemical binding]; other site 1121335006092 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1121335006093 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121335006094 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121335006095 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121335006096 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1121335006097 glutamine binding [chemical binding]; other site 1121335006098 catalytic triad [active] 1121335006099 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1121335006100 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1121335006101 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121335006102 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1121335006103 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121335006104 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121335006105 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121335006106 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1121335006107 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335006108 motif 1; other site 1121335006109 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1121335006110 active site 1121335006111 motif 2; other site 1121335006112 motif 3; other site 1121335006113 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1121335006114 anticodon binding site; other site 1121335006115 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1121335006116 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1121335006117 catalytic site [active] 1121335006118 G-X2-G-X-G-K; other site 1121335006119 hypothetical protein; Provisional; Region: PRK04323 1121335006120 hypothetical protein; Provisional; Region: PRK11820 1121335006121 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1121335006122 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1121335006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006124 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335006125 active site 1121335006126 phosphorylation site [posttranslational modification] 1121335006127 intermolecular recognition site; other site 1121335006128 dimerization interface [polypeptide binding]; other site 1121335006129 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1121335006130 RNA methyltransferase, RsmE family; Region: TIGR00046 1121335006131 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1121335006132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335006133 S-adenosylmethionine binding site [chemical binding]; other site 1121335006134 chaperone protein DnaJ; Provisional; Region: PRK14277 1121335006135 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335006136 HSP70 interaction site [polypeptide binding]; other site 1121335006137 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1121335006138 substrate binding site [polypeptide binding]; other site 1121335006139 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121335006140 Zn binding sites [ion binding]; other site 1121335006141 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121335006142 dimer interface [polypeptide binding]; other site 1121335006143 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1121335006144 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1121335006145 nucleotide binding site [chemical binding]; other site 1121335006146 NEF interaction site [polypeptide binding]; other site 1121335006147 SBD interface [polypeptide binding]; other site 1121335006148 heat shock protein GrpE; Provisional; Region: PRK14140 1121335006149 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1121335006150 dimer interface [polypeptide binding]; other site 1121335006151 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1121335006152 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1121335006153 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1121335006154 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 1121335006155 HemN C-terminal domain; Region: HemN_C; pfam06969 1121335006156 GTP-binding protein LepA; Provisional; Region: PRK05433 1121335006157 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1121335006158 G1 box; other site 1121335006159 putative GEF interaction site [polypeptide binding]; other site 1121335006160 GTP/Mg2+ binding site [chemical binding]; other site 1121335006161 Switch I region; other site 1121335006162 G2 box; other site 1121335006163 G3 box; other site 1121335006164 Switch II region; other site 1121335006165 G4 box; other site 1121335006166 G5 box; other site 1121335006167 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1121335006168 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1121335006169 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1121335006170 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121335006171 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1121335006172 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1121335006173 ligand binding site [chemical binding]; other site 1121335006174 active site 1121335006175 excinuclease ABC subunit B; Provisional; Region: PRK05298 1121335006176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335006177 ATP binding site [chemical binding]; other site 1121335006178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335006179 nucleotide binding region [chemical binding]; other site 1121335006180 ATP-binding site [chemical binding]; other site 1121335006181 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1121335006182 Recombination protein O N terminal; Region: RecO_N; pfam11967 1121335006183 DNA repair protein RecO; Region: reco; TIGR00613 1121335006184 Recombination protein O C terminal; Region: RecO_C; pfam02565 1121335006185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1121335006186 hypothetical protein; Provisional; Region: PRK13663 1121335006187 GTPase Era; Reviewed; Region: era; PRK00089 1121335006188 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1121335006189 G1 box; other site 1121335006190 GTP/Mg2+ binding site [chemical binding]; other site 1121335006191 Switch I region; other site 1121335006192 G2 box; other site 1121335006193 Switch II region; other site 1121335006194 G3 box; other site 1121335006195 G4 box; other site 1121335006196 G5 box; other site 1121335006197 KH domain; Region: KH_2; pfam07650 1121335006198 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1121335006199 active site 1121335006200 catalytic motif [active] 1121335006201 Zn binding site [ion binding]; other site 1121335006202 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1121335006203 Na2 binding site [ion binding]; other site 1121335006204 putative substrate binding site 1 [chemical binding]; other site 1121335006205 Na binding site 1 [ion binding]; other site 1121335006206 putative substrate binding site 2 [chemical binding]; other site 1121335006207 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1121335006208 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335006209 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335006210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335006211 Walker A motif; other site 1121335006212 ATP binding site [chemical binding]; other site 1121335006213 Walker B motif; other site 1121335006214 arginine finger; other site 1121335006215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335006216 Walker A motif; other site 1121335006217 ATP binding site [chemical binding]; other site 1121335006218 Walker B motif; other site 1121335006219 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121335006220 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1121335006221 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335006222 HSP70 interaction site [polypeptide binding]; other site 1121335006223 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121335006224 substrate binding site [polypeptide binding]; other site 1121335006225 dimer interface [polypeptide binding]; other site 1121335006226 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1121335006227 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1121335006228 ligand binding site; other site 1121335006229 oligomer interface; other site 1121335006230 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1121335006231 dimer interface [polypeptide binding]; other site 1121335006232 N-terminal domain interface [polypeptide binding]; other site 1121335006233 sulfate 1 binding site; other site 1121335006234 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 1121335006235 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1121335006236 ligand binding site; other site 1121335006237 oligomer interface; other site 1121335006238 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1121335006239 dimer interface [polypeptide binding]; other site 1121335006240 N-terminal domain interface [polypeptide binding]; other site 1121335006241 sulfate 1 binding site; other site 1121335006242 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1121335006243 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1121335006244 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 1121335006245 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1121335006246 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335006247 catalytic residue [active] 1121335006248 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1121335006249 active site 1121335006250 nucleophile elbow; other site 1121335006251 Thiamine pyrophosphokinase; Region: TPK; cd07995 1121335006252 active site 1121335006253 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1121335006254 dimerization interface [polypeptide binding]; other site 1121335006255 thiamine binding site [chemical binding]; other site 1121335006256 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1121335006257 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1121335006258 substrate binding site [chemical binding]; other site 1121335006259 hexamer interface [polypeptide binding]; other site 1121335006260 metal binding site [ion binding]; metal-binding site 1121335006261 GTPase RsgA; Reviewed; Region: PRK00098 1121335006262 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1121335006263 RNA binding site [nucleotide binding]; other site 1121335006264 homodimer interface [polypeptide binding]; other site 1121335006265 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1121335006266 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1121335006267 GTP/Mg2+ binding site [chemical binding]; other site 1121335006268 G4 box; other site 1121335006269 G5 box; other site 1121335006270 G1 box; other site 1121335006271 Switch I region; other site 1121335006272 G2 box; other site 1121335006273 G3 box; other site 1121335006274 Switch II region; other site 1121335006275 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121335006276 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121335006277 active site 1121335006278 ATP binding site [chemical binding]; other site 1121335006279 substrate binding site [chemical binding]; other site 1121335006280 activation loop (A-loop); other site 1121335006281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121335006282 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121335006283 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121335006284 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121335006285 Protein phosphatase 2C; Region: PP2C; pfam00481 1121335006286 active site 1121335006287 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 1121335006288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006289 FeS/SAM binding site; other site 1121335006290 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1121335006291 NusB family; Region: NusB; pfam01029 1121335006292 putative RNA binding site [nucleotide binding]; other site 1121335006293 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1121335006294 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1121335006295 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1121335006296 active site 1121335006297 dimer interface [polypeptide binding]; other site 1121335006298 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1121335006299 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1121335006300 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121335006301 active site 1121335006302 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1121335006303 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1121335006304 GTP/Mg2+ binding site [chemical binding]; other site 1121335006305 G4 box; other site 1121335006306 G5 box; other site 1121335006307 G1 box; other site 1121335006308 Switch I region; other site 1121335006309 G2 box; other site 1121335006310 G3 box; other site 1121335006311 Switch II region; other site 1121335006312 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1121335006313 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1121335006314 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1121335006315 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1121335006316 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1121335006317 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PLN02538 1121335006318 triosephosphate isomerase; Provisional; Region: PRK14567 1121335006319 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1121335006320 substrate binding site [chemical binding]; other site 1121335006321 dimer interface [polypeptide binding]; other site 1121335006322 catalytic triad [active] 1121335006323 Phosphoglycerate kinase; Region: PGK; pfam00162 1121335006324 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1121335006325 substrate binding site [chemical binding]; other site 1121335006326 hinge regions; other site 1121335006327 ADP binding site [chemical binding]; other site 1121335006328 catalytic site [active] 1121335006329 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 1121335006330 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1121335006331 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121335006332 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121335006333 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1121335006334 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121335006335 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1121335006336 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1121335006337 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1121335006338 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1121335006339 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1121335006340 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1121335006341 Competence protein; Region: Competence; pfam03772 1121335006342 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1121335006343 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335006344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335006345 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121335006346 Coenzyme A binding pocket [chemical binding]; other site 1121335006347 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1121335006348 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121335006349 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1121335006350 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1121335006351 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1121335006352 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1121335006353 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1121335006354 NAD binding site [chemical binding]; other site 1121335006355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335006356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335006357 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335006358 Walker A/P-loop; other site 1121335006359 ATP binding site [chemical binding]; other site 1121335006360 Q-loop/lid; other site 1121335006361 ABC transporter signature motif; other site 1121335006362 Walker B; other site 1121335006363 D-loop; other site 1121335006364 H-loop/switch region; other site 1121335006365 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335006366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335006367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335006368 Walker A/P-loop; other site 1121335006369 ATP binding site [chemical binding]; other site 1121335006370 Q-loop/lid; other site 1121335006371 ABC transporter signature motif; other site 1121335006372 Walker B; other site 1121335006373 D-loop; other site 1121335006374 H-loop/switch region; other site 1121335006375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121335006376 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121335006377 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335006378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335006379 motif II; other site 1121335006380 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1121335006381 active site 1121335006382 dimer interface [polypeptide binding]; other site 1121335006383 dihydroorotase; Validated; Region: pyrC; PRK09357 1121335006384 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121335006385 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1121335006386 active site 1121335006387 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1121335006388 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121335006389 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121335006390 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1121335006391 Protein export membrane protein; Region: SecD_SecF; cl14618 1121335006392 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1121335006393 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1121335006394 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 1121335006395 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 1121335006396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006397 FeS/SAM binding site; other site 1121335006398 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121335006399 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 1121335006400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335006401 non-specific DNA binding site [nucleotide binding]; other site 1121335006402 salt bridge; other site 1121335006403 sequence-specific DNA binding site [nucleotide binding]; other site 1121335006404 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1121335006405 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1121335006406 active site 1121335006407 HIGH motif; other site 1121335006408 dimer interface [polypeptide binding]; other site 1121335006409 KMSKS motif; other site 1121335006410 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335006411 RNA binding surface [nucleotide binding]; other site 1121335006412 Transglycosylase; Region: Transgly; pfam00912 1121335006413 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1121335006414 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1121335006415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006416 active site 1121335006417 phosphorylation site [posttranslational modification] 1121335006418 intermolecular recognition site; other site 1121335006419 dimerization interface [polypeptide binding]; other site 1121335006420 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1121335006421 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1121335006422 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1121335006423 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 1121335006424 active site 1121335006425 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1121335006426 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1121335006427 folate binding site [chemical binding]; other site 1121335006428 NADP+ binding site [chemical binding]; other site 1121335006429 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1121335006430 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1121335006431 dimerization interface [polypeptide binding]; other site 1121335006432 active site 1121335006433 Glucuronate isomerase; Region: UxaC; pfam02614 1121335006434 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1121335006435 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335006436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335006437 DNA binding site [nucleotide binding] 1121335006438 domain linker motif; other site 1121335006439 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335006440 dimerization interface [polypeptide binding]; other site 1121335006441 ligand binding site [chemical binding]; other site 1121335006442 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1121335006443 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1121335006444 NAD binding site [chemical binding]; other site 1121335006445 dimer interface [polypeptide binding]; other site 1121335006446 substrate binding site [chemical binding]; other site 1121335006447 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121335006448 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1121335006449 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1121335006450 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1121335006451 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1121335006452 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1121335006453 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1121335006454 purine monophosphate binding site [chemical binding]; other site 1121335006455 dimer interface [polypeptide binding]; other site 1121335006456 putative catalytic residues [active] 1121335006457 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1121335006458 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1121335006459 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1121335006460 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1121335006461 active site 1121335006462 substrate binding site [chemical binding]; other site 1121335006463 cosubstrate binding site; other site 1121335006464 catalytic site [active] 1121335006465 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1121335006466 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1121335006467 dimerization interface [polypeptide binding]; other site 1121335006468 putative ATP binding site [chemical binding]; other site 1121335006469 AIR carboxylase; Region: AIRC; pfam00731 1121335006470 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1121335006471 6-phosphofructokinase; Provisional; Region: PRK03202 1121335006472 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1121335006473 active site 1121335006474 ADP/pyrophosphate binding site [chemical binding]; other site 1121335006475 dimerization interface [polypeptide binding]; other site 1121335006476 allosteric effector site; other site 1121335006477 fructose-1,6-bisphosphate binding site; other site 1121335006478 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1121335006479 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121335006480 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121335006481 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1121335006482 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1121335006483 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121335006484 HIGH motif; other site 1121335006485 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121335006486 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121335006487 active site 1121335006488 KMSKS motif; other site 1121335006489 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1121335006490 tRNA binding surface [nucleotide binding]; other site 1121335006491 anticodon binding site; other site 1121335006492 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1121335006493 CotJB protein; Region: CotJB; pfam12652 1121335006494 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121335006495 VanZ like family; Region: VanZ; cl01971 1121335006496 HTH-like domain; Region: HTH_21; pfam13276 1121335006497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121335006498 Integrase core domain; Region: rve; pfam00665 1121335006499 Integrase core domain; Region: rve_3; pfam13683 1121335006500 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1121335006501 catalytic residues [active] 1121335006502 catalytic nucleophile [active] 1121335006503 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121335006504 Recombinase; Region: Recombinase; pfam07508 1121335006505 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1121335006506 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121335006507 dinuclear metal binding motif [ion binding]; other site 1121335006508 enolase; Provisional; Region: eno; PRK00077 1121335006509 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1121335006510 dimer interface [polypeptide binding]; other site 1121335006511 metal binding site [ion binding]; metal-binding site 1121335006512 substrate binding pocket [chemical binding]; other site 1121335006513 hypothetical protein; Provisional; Region: PRK05473 1121335006514 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1121335006515 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121335006516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006517 FeS/SAM binding site; other site 1121335006518 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121335006519 regulatory protein interface [polypeptide binding]; other site 1121335006520 regulatory phosphorylation site [posttranslational modification]; other site 1121335006521 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1121335006522 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1121335006523 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1121335006524 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1121335006525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335006526 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1121335006527 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1121335006528 Spore germination protein; Region: Spore_permease; cl17796 1121335006529 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335006530 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335006531 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1121335006532 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1121335006533 PCRF domain; Region: PCRF; pfam03462 1121335006534 RF-1 domain; Region: RF-1; pfam00472 1121335006535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335006536 Protein of unknown function (DUF970); Region: DUF970; cl17525 1121335006537 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1121335006538 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121335006539 active site 1121335006540 HIGH motif; other site 1121335006541 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121335006542 active site 1121335006543 KMSKS motif; other site 1121335006544 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335006545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006546 FeS/SAM binding site; other site 1121335006547 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1121335006548 Family description; Region: UvrD_C_2; pfam13538 1121335006549 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1121335006550 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1121335006551 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121335006552 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1121335006553 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1121335006554 NAD(P) binding site [chemical binding]; other site 1121335006555 catalytic residues [active] 1121335006556 cell division protein FtsZ; Validated; Region: PRK09330 1121335006557 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1121335006558 nucleotide binding site [chemical binding]; other site 1121335006559 SulA interaction site; other site 1121335006560 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1121335006561 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1121335006562 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1121335006563 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121335006564 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121335006565 hinge; other site 1121335006566 active site 1121335006567 cell division protein FtsW; Region: ftsW; TIGR02614 1121335006568 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1121335006569 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1121335006570 Mg++ binding site [ion binding]; other site 1121335006571 putative catalytic motif [active] 1121335006572 putative substrate binding site [chemical binding]; other site 1121335006573 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1121335006574 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121335006575 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335006576 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335006577 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1121335006578 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121335006579 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335006580 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335006581 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1121335006582 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121335006583 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121335006584 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1121335006585 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1121335006586 Cell division protein FtsL; Region: FtsL; cl11433 1121335006587 MraW methylase family; Region: Methyltransf_5; pfam01795 1121335006588 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1121335006589 cell division protein MraZ; Reviewed; Region: PRK00326 1121335006590 MraZ protein; Region: MraZ; pfam02381 1121335006591 MraZ protein; Region: MraZ; pfam02381 1121335006592 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1121335006593 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1121335006594 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121335006595 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1121335006596 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121335006597 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121335006598 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121335006599 Haemolysin-III related; Region: HlyIII; cl03831 1121335006600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335006601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335006602 metal binding site [ion binding]; metal-binding site 1121335006603 active site 1121335006604 I-site; other site 1121335006605 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1121335006606 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335006607 Predicted periplasmic protein [Function unknown]; Region: COG3698 1121335006608 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 1121335006609 catalytic domain interface [polypeptide binding]; other site 1121335006610 putative homodimer interface [polypeptide binding]; other site 1121335006611 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1121335006612 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1121335006613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335006614 Zn2+ binding site [ion binding]; other site 1121335006615 Mg2+ binding site [ion binding]; other site 1121335006616 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121335006617 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121335006618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335006619 S-adenosylmethionine binding site [chemical binding]; other site 1121335006620 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1121335006621 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1121335006622 homotetramer interface [polypeptide binding]; other site 1121335006623 ligand binding site [chemical binding]; other site 1121335006624 catalytic site [active] 1121335006625 NAD binding site [chemical binding]; other site 1121335006626 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1121335006627 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1121335006628 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1121335006629 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1121335006630 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1121335006631 heterotetramer interface [polypeptide binding]; other site 1121335006632 active site pocket [active] 1121335006633 cleavage site 1121335006634 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121335006635 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121335006636 GAF domain; Region: GAF_3; pfam13492 1121335006637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335006638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335006639 metal binding site [ion binding]; metal-binding site 1121335006640 active site 1121335006641 I-site; other site 1121335006642 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1121335006643 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121335006644 minor groove reading motif; other site 1121335006645 helix-hairpin-helix signature motif; other site 1121335006646 substrate binding pocket [chemical binding]; other site 1121335006647 active site 1121335006648 glycogen synthase; Provisional; Region: glgA; PRK00654 1121335006649 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1121335006650 ADP-binding pocket [chemical binding]; other site 1121335006651 homodimer interface [polypeptide binding]; other site 1121335006652 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1121335006653 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1121335006654 RNase E interface [polypeptide binding]; other site 1121335006655 trimer interface [polypeptide binding]; other site 1121335006656 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1121335006657 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1121335006658 RNase E interface [polypeptide binding]; other site 1121335006659 trimer interface [polypeptide binding]; other site 1121335006660 active site 1121335006661 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1121335006662 putative nucleic acid binding region [nucleotide binding]; other site 1121335006663 G-X-X-G motif; other site 1121335006664 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1121335006665 RNA binding site [nucleotide binding]; other site 1121335006666 domain interface; other site 1121335006667 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1121335006668 16S/18S rRNA binding site [nucleotide binding]; other site 1121335006669 S13e-L30e interaction site [polypeptide binding]; other site 1121335006670 25S rRNA binding site [nucleotide binding]; other site 1121335006671 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335006672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335006673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335006674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006675 dimer interface [polypeptide binding]; other site 1121335006676 conserved gate region; other site 1121335006677 putative PBP binding loops; other site 1121335006678 ABC-ATPase subunit interface; other site 1121335006679 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335006680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006681 dimer interface [polypeptide binding]; other site 1121335006682 conserved gate region; other site 1121335006683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335006684 ABC-ATPase subunit interface; other site 1121335006685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335006686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006687 PBP superfamily domain; Region: PBP_like_2; cl17296 1121335006688 PBP superfamily domain; Region: PBP_like_2; cl17296 1121335006689 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1121335006690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006691 dimer interface [polypeptide binding]; other site 1121335006692 conserved gate region; other site 1121335006693 putative PBP binding loops; other site 1121335006694 ABC-ATPase subunit interface; other site 1121335006695 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121335006696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006697 dimer interface [polypeptide binding]; other site 1121335006698 conserved gate region; other site 1121335006699 putative PBP binding loops; other site 1121335006700 ABC-ATPase subunit interface; other site 1121335006701 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1121335006702 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121335006703 Walker A/P-loop; other site 1121335006704 ATP binding site [chemical binding]; other site 1121335006705 Q-loop/lid; other site 1121335006706 ABC transporter signature motif; other site 1121335006707 Walker B; other site 1121335006708 D-loop; other site 1121335006709 H-loop/switch region; other site 1121335006710 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121335006711 PhoU domain; Region: PhoU; pfam01895 1121335006712 PhoU domain; Region: PhoU; pfam01895 1121335006713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335006715 active site 1121335006716 phosphorylation site [posttranslational modification] 1121335006717 intermolecular recognition site; other site 1121335006718 dimerization interface [polypeptide binding]; other site 1121335006719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335006720 DNA binding site [nucleotide binding] 1121335006721 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121335006722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335006723 putative active site [active] 1121335006724 heme pocket [chemical binding]; other site 1121335006725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335006726 dimer interface [polypeptide binding]; other site 1121335006727 phosphorylation site [posttranslational modification] 1121335006728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335006729 ATP binding site [chemical binding]; other site 1121335006730 Mg2+ binding site [ion binding]; other site 1121335006731 G-X-G motif; other site 1121335006732 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1121335006733 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1121335006734 dimer interface [polypeptide binding]; other site 1121335006735 active site 1121335006736 metal binding site [ion binding]; metal-binding site 1121335006737 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1121335006738 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335006739 active site 1121335006740 catalytic tetrad [active] 1121335006741 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121335006742 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121335006743 Walker A/P-loop; other site 1121335006744 ATP binding site [chemical binding]; other site 1121335006745 Q-loop/lid; other site 1121335006746 ABC transporter signature motif; other site 1121335006747 Walker B; other site 1121335006748 D-loop; other site 1121335006749 H-loop/switch region; other site 1121335006750 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121335006751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335006752 ABC-ATPase subunit interface; other site 1121335006753 dimer interface [polypeptide binding]; other site 1121335006754 putative PBP binding regions; other site 1121335006755 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1121335006756 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1121335006757 putative binding site residues; other site 1121335006758 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1121335006759 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1121335006760 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1121335006761 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1121335006762 recombinase A; Provisional; Region: recA; PRK09354 1121335006763 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1121335006764 hexamer interface [polypeptide binding]; other site 1121335006765 Walker A motif; other site 1121335006766 ATP binding site [chemical binding]; other site 1121335006767 Walker B motif; other site 1121335006768 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335006769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006770 dimer interface [polypeptide binding]; other site 1121335006771 conserved gate region; other site 1121335006772 putative PBP binding loops; other site 1121335006773 ABC-ATPase subunit interface; other site 1121335006774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335006775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006776 dimer interface [polypeptide binding]; other site 1121335006777 conserved gate region; other site 1121335006778 putative PBP binding loops; other site 1121335006779 ABC-ATPase subunit interface; other site 1121335006780 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335006781 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335006782 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335006783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006784 active site 1121335006785 phosphorylation site [posttranslational modification] 1121335006786 intermolecular recognition site; other site 1121335006787 dimerization interface [polypeptide binding]; other site 1121335006788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006789 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335006790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335006791 dimerization interface [polypeptide binding]; other site 1121335006792 Histidine kinase; Region: His_kinase; pfam06580 1121335006793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335006794 ATP binding site [chemical binding]; other site 1121335006795 Mg2+ binding site [ion binding]; other site 1121335006796 G-X-G motif; other site 1121335006797 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1121335006798 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1121335006799 competence damage-inducible protein A; Provisional; Region: PRK00549 1121335006800 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1121335006801 putative MPT binding site; other site 1121335006802 Competence-damaged protein; Region: CinA; pfam02464 1121335006803 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1121335006804 G1 box; other site 1121335006805 GTP/Mg2+ binding site [chemical binding]; other site 1121335006806 Switch I region; other site 1121335006807 G2 box; other site 1121335006808 G3 box; other site 1121335006809 Switch II region; other site 1121335006810 G4 box; other site 1121335006811 G5 box; other site 1121335006812 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1121335006813 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121335006814 Walker A/P-loop; other site 1121335006815 ATP binding site [chemical binding]; other site 1121335006816 Q-loop/lid; other site 1121335006817 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121335006818 ABC transporter signature motif; other site 1121335006819 Walker B; other site 1121335006820 D-loop; other site 1121335006821 H-loop/switch region; other site 1121335006822 arginine repressor; Provisional; Region: argR; PRK00441 1121335006823 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1121335006824 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1121335006825 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1121335006826 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1121335006827 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1121335006828 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335006829 RNA binding surface [nucleotide binding]; other site 1121335006830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335006831 S-adenosylmethionine binding site [chemical binding]; other site 1121335006832 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1121335006833 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1121335006834 TPP-binding site; other site 1121335006835 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121335006836 PYR/PP interface [polypeptide binding]; other site 1121335006837 dimer interface [polypeptide binding]; other site 1121335006838 TPP binding site [chemical binding]; other site 1121335006839 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335006840 Divergent PAP2 family; Region: DUF212; pfam02681 1121335006841 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121335006842 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121335006843 substrate binding pocket [chemical binding]; other site 1121335006844 chain length determination region; other site 1121335006845 substrate-Mg2+ binding site; other site 1121335006846 catalytic residues [active] 1121335006847 aspartate-rich region 1; other site 1121335006848 active site lid residues [active] 1121335006849 aspartate-rich region 2; other site 1121335006850 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1121335006851 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1121335006852 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1121335006853 generic binding surface II; other site 1121335006854 generic binding surface I; other site 1121335006855 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1121335006856 putative RNA binding site [nucleotide binding]; other site 1121335006857 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335006858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335006859 DNA binding site [nucleotide binding] 1121335006860 domain linker motif; other site 1121335006861 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335006862 dimerization interface [polypeptide binding]; other site 1121335006863 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335006864 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335006865 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335006866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006867 dimer interface [polypeptide binding]; other site 1121335006868 conserved gate region; other site 1121335006869 putative PBP binding loops; other site 1121335006870 ABC-ATPase subunit interface; other site 1121335006871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006872 dimer interface [polypeptide binding]; other site 1121335006873 conserved gate region; other site 1121335006874 putative PBP binding loops; other site 1121335006875 ABC-ATPase subunit interface; other site 1121335006876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335006877 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121335006878 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1121335006879 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1121335006880 active site 1121335006881 catalytic site [active] 1121335006882 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1121335006883 active site 1121335006884 Putative esterase; Region: Esterase; pfam00756 1121335006885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1121335006886 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1121335006887 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1121335006888 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1121335006889 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1121335006890 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1121335006891 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121335006892 ligand binding site [chemical binding]; other site 1121335006893 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121335006894 flagellar motor protein MotP; Reviewed; Region: PRK06926 1121335006895 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1121335006896 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121335006897 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121335006898 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121335006899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335006900 Coenzyme A binding pocket [chemical binding]; other site 1121335006901 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335006902 Zn2+ binding site [ion binding]; other site 1121335006903 Mg2+ binding site [ion binding]; other site 1121335006904 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121335006905 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335006906 Zn2+ binding site [ion binding]; other site 1121335006907 Mg2+ binding site [ion binding]; other site 1121335006908 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1121335006909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006910 TPR motif; other site 1121335006911 binding surface 1121335006912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006913 TPR motif; other site 1121335006914 binding surface 1121335006915 TPR repeat; Region: TPR_11; pfam13414 1121335006916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006917 binding surface 1121335006918 TPR motif; other site 1121335006919 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335006920 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335006921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006922 binding surface 1121335006923 TPR motif; other site 1121335006924 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335006925 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335006926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006928 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1121335006929 catalytic core [active] 1121335006930 YcxB-like protein; Region: YcxB; pfam14317 1121335006931 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121335006932 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121335006933 synthetase active site [active] 1121335006934 NTP binding site [chemical binding]; other site 1121335006935 metal binding site [ion binding]; metal-binding site 1121335006936 hypothetical protein; Reviewed; Region: PRK09588 1121335006937 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1121335006938 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1121335006939 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121335006940 PYR/PP interface [polypeptide binding]; other site 1121335006941 dimer interface [polypeptide binding]; other site 1121335006942 TPP binding site [chemical binding]; other site 1121335006943 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335006944 transketolase; Reviewed; Region: PRK05899 1121335006945 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121335006946 TPP-binding site [chemical binding]; other site 1121335006947 dimer interface [polypeptide binding]; other site 1121335006948 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1121335006949 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1121335006950 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1121335006951 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1121335006952 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1121335006953 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1121335006954 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1121335006955 NAD binding site [chemical binding]; other site 1121335006956 homodimer interface [polypeptide binding]; other site 1121335006957 active site 1121335006958 substrate binding site [chemical binding]; other site 1121335006959 galactokinase; Provisional; Region: PRK05322 1121335006960 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1121335006961 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1121335006962 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1121335006963 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1121335006964 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1121335006965 dimer interface [polypeptide binding]; other site 1121335006966 active site 1121335006967 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335006968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006969 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335006970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006971 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121335006972 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121335006973 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335006974 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1121335006975 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1121335006976 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121335006977 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121335006978 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335006979 Walker A/P-loop; other site 1121335006980 ATP binding site [chemical binding]; other site 1121335006981 Q-loop/lid; other site 1121335006982 ABC transporter signature motif; other site 1121335006983 Walker B; other site 1121335006984 D-loop; other site 1121335006985 H-loop/switch region; other site 1121335006986 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1121335006987 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121335006988 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335006989 Walker A/P-loop; other site 1121335006990 ATP binding site [chemical binding]; other site 1121335006991 Q-loop/lid; other site 1121335006992 ABC transporter signature motif; other site 1121335006993 Walker B; other site 1121335006994 D-loop; other site 1121335006995 H-loop/switch region; other site 1121335006996 hypothetical protein; Provisional; Region: PRK13661 1121335006997 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1121335006998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335006999 S-adenosylmethionine binding site [chemical binding]; other site 1121335007000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1121335007001 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121335007002 G5 domain; Region: G5; pfam07501 1121335007003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1121335007004 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 1121335007005 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1121335007006 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1121335007007 active site 1121335007008 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1121335007009 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1121335007010 HIGH motif; other site 1121335007011 active site 1121335007012 KMSKS motif; other site 1121335007013 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1121335007014 tRNA binding surface [nucleotide binding]; other site 1121335007015 anticodon binding site; other site 1121335007016 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1121335007017 putative tRNA-binding site [nucleotide binding]; other site 1121335007018 dimer interface [polypeptide binding]; other site 1121335007019 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1121335007020 homotrimer interaction site [polypeptide binding]; other site 1121335007021 zinc binding site [ion binding]; other site 1121335007022 CDP-binding sites; other site 1121335007023 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1121335007024 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335007025 Walker A/P-loop; other site 1121335007026 ATP binding site [chemical binding]; other site 1121335007027 Q-loop/lid; other site 1121335007028 ABC transporter signature motif; other site 1121335007029 Walker B; other site 1121335007030 D-loop; other site 1121335007031 H-loop/switch region; other site 1121335007032 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1121335007033 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1121335007034 CoA binding domain; Region: CoA_binding; smart00881 1121335007035 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121335007036 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121335007037 substrate binding site [chemical binding]; other site 1121335007038 glutamase interaction surface [polypeptide binding]; other site 1121335007039 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1121335007040 intersubunit interface [polypeptide binding]; other site 1121335007041 active site 1121335007042 Zn2+ binding site [ion binding]; other site 1121335007043 intersubunit interface [polypeptide binding]; other site 1121335007044 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1121335007045 active site 1121335007046 Zn2+ binding site [ion binding]; other site 1121335007047 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1121335007048 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1121335007049 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121335007050 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121335007051 catalytic residues [active] 1121335007052 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 1121335007053 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1121335007054 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1121335007055 dimerization interface [polypeptide binding]; other site 1121335007056 domain crossover interface; other site 1121335007057 redox-dependent activation switch; other site 1121335007058 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1121335007059 putative active site [active] 1121335007060 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1121335007061 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121335007062 DNA binding site [nucleotide binding] 1121335007063 active site 1121335007064 Protease prsW family; Region: PrsW-protease; pfam13367 1121335007065 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1121335007066 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121335007067 minor groove reading motif; other site 1121335007068 helix-hairpin-helix signature motif; other site 1121335007069 substrate binding pocket [chemical binding]; other site 1121335007070 active site 1121335007071 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 1121335007072 putative FMN binding site [chemical binding]; other site 1121335007073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1121335007074 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1121335007075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335007076 Walker A/P-loop; other site 1121335007077 ATP binding site [chemical binding]; other site 1121335007078 Q-loop/lid; other site 1121335007079 ABC transporter signature motif; other site 1121335007080 Walker B; other site 1121335007081 D-loop; other site 1121335007082 H-loop/switch region; other site 1121335007083 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121335007084 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1121335007085 prephenate dehydrogenase; Validated; Region: PRK06545 1121335007086 prephenate dehydrogenase; Validated; Region: PRK08507 1121335007087 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1121335007088 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121335007089 conserved cys residue [active] 1121335007090 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1121335007091 spermidine synthase; Provisional; Region: PRK00811 1121335007092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335007093 S-adenosylmethionine binding site [chemical binding]; other site 1121335007094 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335007095 metal ion-dependent adhesion site (MIDAS); other site 1121335007096 Protein of unknown function DUF45; Region: DUF45; pfam01863 1121335007097 pyruvate kinase; Provisional; Region: PRK06354 1121335007098 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1121335007099 domain interfaces; other site 1121335007100 active site 1121335007101 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1121335007102 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 1121335007103 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1121335007104 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1121335007105 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1121335007106 active site 1121335007107 RHS Repeat; Region: RHS_repeat; pfam05593 1121335007108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335007109 MULE transposase domain; Region: MULE; pfam10551 1121335007110 RHS Repeat; Region: RHS_repeat; pfam05593 1121335007111 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121335007112 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121335007113 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121335007114 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121335007115 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121335007116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335007117 FeS/SAM binding site; other site 1121335007118 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1121335007119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121335007120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121335007121 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121335007122 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121335007123 ring oligomerisation interface [polypeptide binding]; other site 1121335007124 ATP/Mg binding site [chemical binding]; other site 1121335007125 stacking interactions; other site 1121335007126 hinge regions; other site 1121335007127 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121335007128 oligomerisation interface [polypeptide binding]; other site 1121335007129 mobile loop; other site 1121335007130 roof hairpin; other site 1121335007131 Uncharacterized conserved protein [Function unknown]; Region: COG2454 1121335007132 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1121335007133 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335007134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007135 dimer interface [polypeptide binding]; other site 1121335007136 conserved gate region; other site 1121335007137 putative PBP binding loops; other site 1121335007138 ABC-ATPase subunit interface; other site 1121335007139 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335007140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007141 dimer interface [polypeptide binding]; other site 1121335007142 conserved gate region; other site 1121335007143 putative PBP binding loops; other site 1121335007144 ABC-ATPase subunit interface; other site 1121335007145 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335007146 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121335007147 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335007148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335007149 active site 1121335007150 phosphorylation site [posttranslational modification] 1121335007151 intermolecular recognition site; other site 1121335007152 dimerization interface [polypeptide binding]; other site 1121335007153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335007154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335007155 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335007156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335007157 dimerization interface [polypeptide binding]; other site 1121335007158 Histidine kinase; Region: His_kinase; pfam06580 1121335007159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335007160 ATP binding site [chemical binding]; other site 1121335007161 Mg2+ binding site [ion binding]; other site 1121335007162 G-X-G motif; other site 1121335007163 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1121335007164 Part of AAA domain; Region: AAA_19; pfam13245 1121335007165 Family description; Region: UvrD_C_2; pfam13538 1121335007166 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121335007167 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121335007168 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 1121335007169 dimer interface [polypeptide binding]; other site 1121335007170 Citrate synthase; Region: Citrate_synt; pfam00285 1121335007171 active site 1121335007172 citrylCoA binding site [chemical binding]; other site 1121335007173 oxalacetate/citrate binding site [chemical binding]; other site 1121335007174 coenzyme A binding site [chemical binding]; other site 1121335007175 catalytic triad [active] 1121335007176 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1121335007177 Ligand Binding Site [chemical binding]; other site 1121335007178 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1121335007179 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1121335007180 substrate-cofactor binding pocket; other site 1121335007181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335007182 catalytic residue [active] 1121335007183 short chain dehydrogenase; Validated; Region: PRK06182 1121335007184 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1121335007185 NADP binding site [chemical binding]; other site 1121335007186 active site 1121335007187 steroid binding site; other site 1121335007188 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1121335007189 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1121335007190 NodB motif; other site 1121335007191 active site 1121335007192 catalytic site [active] 1121335007193 metal binding site [ion binding]; metal-binding site 1121335007194 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121335007195 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335007196 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335007197 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121335007198 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335007199 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335007200 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121335007201 IMP binding site; other site 1121335007202 dimer interface [polypeptide binding]; other site 1121335007203 interdomain contacts; other site 1121335007204 partial ornithine binding site; other site 1121335007205 amidophosphoribosyltransferase; Region: purF; TIGR01134 1121335007206 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1121335007207 active site 1121335007208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007209 active site 1121335007210 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1121335007211 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335007212 metal ion-dependent adhesion site (MIDAS); other site 1121335007213 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335007214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007215 Walker A motif; other site 1121335007216 ATP binding site [chemical binding]; other site 1121335007217 Walker B motif; other site 1121335007218 arginine finger; other site 1121335007219 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335007220 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335007221 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1121335007222 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1121335007223 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121335007224 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121335007225 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1121335007226 phosphopentomutase; Provisional; Region: PRK05362 1121335007227 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1121335007228 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1121335007229 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335007230 putative active site [active] 1121335007231 putative metal binding site [ion binding]; other site 1121335007232 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1121335007233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121335007234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335007235 catalytic residue [active] 1121335007236 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121335007237 active site 1121335007238 catalytic triad [active] 1121335007239 oxyanion hole [active] 1121335007240 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1121335007241 Fe-S cluster binding site [ion binding]; other site 1121335007242 active site 1121335007243 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1121335007244 transcription termination factor Rho; Provisional; Region: PRK12608 1121335007245 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1121335007246 RNA binding site [nucleotide binding]; other site 1121335007247 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1121335007248 multimer interface [polypeptide binding]; other site 1121335007249 Walker A motif; other site 1121335007250 ATP binding site [chemical binding]; other site 1121335007251 Walker B motif; other site 1121335007252 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1121335007253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007254 Walker A motif; other site 1121335007255 ATP binding site [chemical binding]; other site 1121335007256 Walker B motif; other site 1121335007257 arginine finger; other site 1121335007258 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1121335007259 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335007260 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121335007261 active site 1121335007262 metal binding site [ion binding]; metal-binding site 1121335007263 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1121335007264 hypothetical protein; Validated; Region: PRK00110 1121335007265 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1121335007266 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1121335007267 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1121335007268 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1121335007269 active site 1121335007270 Ap6A binding site [chemical binding]; other site 1121335007271 nudix motif; other site 1121335007272 metal binding site [ion binding]; metal-binding site 1121335007273 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1121335007274 30S subunit binding site; other site 1121335007275 Outer membrane efflux protein; Region: OEP; pfam02321 1121335007276 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1121335007277 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335007278 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1121335007279 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121335007280 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1121335007281 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1121335007282 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1121335007283 dimer interface [polypeptide binding]; other site 1121335007284 motif 1; other site 1121335007285 active site 1121335007286 motif 2; other site 1121335007287 motif 3; other site 1121335007288 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1121335007289 anticodon binding site; other site 1121335007290 zinc-binding site [ion binding]; other site 1121335007291 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 1121335007292 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1121335007293 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1121335007294 hypothetical protein; Reviewed; Region: PRK00024 1121335007295 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1121335007296 MPN+ (JAMM) motif; other site 1121335007297 Zinc-binding site [ion binding]; other site 1121335007298 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121335007299 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121335007300 active site 1121335007301 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121335007302 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1121335007303 Cl- selectivity filter; other site 1121335007304 Cl- binding residues [ion binding]; other site 1121335007305 pore gating glutamate residue; other site 1121335007306 dimer interface [polypeptide binding]; other site 1121335007307 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1121335007308 UGMP family protein; Validated; Region: PRK09604 1121335007309 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1121335007310 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1121335007311 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1121335007312 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1121335007313 SpoVA protein; Region: SpoVA; cl04298 1121335007314 stage V sporulation protein AD; Validated; Region: PRK08304 1121335007315 stage V sporulation protein AD; Provisional; Region: PRK12404 1121335007316 SpoVA protein; Region: SpoVA; cl04298 1121335007317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007318 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121335007319 Walker A motif; other site 1121335007320 ATP binding site [chemical binding]; other site 1121335007321 Walker B motif; other site 1121335007322 arginine finger; other site 1121335007323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007324 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121335007325 Walker A motif; other site 1121335007326 ATP binding site [chemical binding]; other site 1121335007327 Walker B motif; other site 1121335007328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121335007329 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121335007330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121335007331 ATP binding site [chemical binding]; other site 1121335007332 Mg2+ binding site [ion binding]; other site 1121335007333 G-X-G motif; other site 1121335007334 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1121335007335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335007336 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335007337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335007338 DNA binding residues [nucleotide binding] 1121335007339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121335007340 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121335007341 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121335007342 anti sigma factor interaction site; other site 1121335007343 regulatory phosphorylation site [posttranslational modification]; other site 1121335007344 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1121335007345 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1121335007346 dimer interface [polypeptide binding]; other site 1121335007347 putative anticodon binding site; other site 1121335007348 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1121335007349 motif 1; other site 1121335007350 active site 1121335007351 motif 2; other site 1121335007352 motif 3; other site 1121335007353 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1121335007354 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1121335007355 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1121335007356 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1121335007357 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1121335007358 GIY-YIG motif/motif A; other site 1121335007359 active site 1121335007360 catalytic site [active] 1121335007361 putative DNA binding site [nucleotide binding]; other site 1121335007362 metal binding site [ion binding]; metal-binding site 1121335007363 UvrB/uvrC motif; Region: UVR; pfam02151 1121335007364 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1121335007365 Helix-hairpin-helix motif; Region: HHH; pfam00633 1121335007366 helix-hairpin-helix signature motif; other site 1121335007367 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121335007368 dimerization domain swap beta strand [polypeptide binding]; other site 1121335007369 regulatory protein interface [polypeptide binding]; other site 1121335007370 active site 1121335007371 regulatory phosphorylation site [posttranslational modification]; other site 1121335007372 Putative zinc-finger; Region: zf-HC2; pfam13490 1121335007373 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1121335007374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335007375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335007376 DNA binding residues [nucleotide binding] 1121335007377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335007378 dimerization interface [polypeptide binding]; other site 1121335007379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335007380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335007381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335007382 dimer interface [polypeptide binding]; other site 1121335007383 putative CheW interface [polypeptide binding]; other site 1121335007384 ferredoxin; Validated; Region: PRK07118 1121335007385 Putative Fe-S cluster; Region: FeS; cl17515 1121335007386 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335007387 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1121335007388 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1121335007389 FMN-binding domain; Region: FMN_bind; cl01081 1121335007390 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1121335007391 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1121335007392 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1121335007393 SLBB domain; Region: SLBB; pfam10531 1121335007394 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335007395 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1121335007396 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1121335007397 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1121335007398 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1121335007399 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121335007400 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1121335007401 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121335007402 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1121335007403 dimerization interface [polypeptide binding]; other site 1121335007404 active site 1121335007405 metal binding site [ion binding]; metal-binding site 1121335007406 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121335007407 catalytic residues [active] 1121335007408 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121335007409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335007410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335007411 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1121335007412 catalytic residues [active] 1121335007413 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121335007414 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1121335007415 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121335007416 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121335007417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335007418 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121335007419 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1121335007420 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1121335007421 O-Antigen ligase; Region: Wzy_C; cl04850 1121335007422 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 1121335007423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335007424 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1121335007425 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1121335007426 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 1121335007427 V-type ATP synthase subunit B; Provisional; Region: PRK04196 1121335007428 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335007429 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1121335007430 Walker A motif homologous position; other site 1121335007431 Walker B motif; other site 1121335007432 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335007433 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1121335007434 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335007435 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1121335007436 Walker A motif/ATP binding site; other site 1121335007437 Walker B motif; other site 1121335007438 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335007439 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 1121335007440 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 1121335007441 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1121335007442 V-type ATP synthase subunit I; Validated; Region: PRK05771 1121335007443 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 1121335007444 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 1121335007445 acetylornithine aminotransferase; Provisional; Region: PRK02627 1121335007446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121335007447 inhibitor-cofactor binding pocket; inhibition site 1121335007448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335007449 catalytic residue [active] 1121335007450 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1121335007451 metal binding site [ion binding]; metal-binding site 1121335007452 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1121335007453 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335007454 MULE transposase domain; Region: MULE; pfam10551 1121335007455 germination protein YpeB; Region: spore_YpeB; TIGR02889 1121335007456 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335007457 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1121335007458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335007459 Walker A/P-loop; other site 1121335007460 ATP binding site [chemical binding]; other site 1121335007461 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1121335007462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335007463 active site 1121335007464 metal binding site [ion binding]; metal-binding site 1121335007465 DNA binding site [nucleotide binding] 1121335007466 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1121335007467 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335007468 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1121335007469 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1121335007470 active site 1121335007471 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1121335007472 active site 1121335007473 putative substrate binding region [chemical binding]; other site 1121335007474 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1121335007475 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1121335007476 catalytic residues [active] 1121335007477 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1121335007478 ATP binding site [chemical binding]; other site 1121335007479 active site 1121335007480 substrate binding site [chemical binding]; other site 1121335007481 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1121335007482 putative active site pocket [active] 1121335007483 4-fold oligomerization interface [polypeptide binding]; other site 1121335007484 metal binding residues [ion binding]; metal-binding site 1121335007485 3-fold/trimer interface [polypeptide binding]; other site 1121335007486 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1121335007487 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335007488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335007489 homodimer interface [polypeptide binding]; other site 1121335007490 catalytic residue [active] 1121335007491 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1121335007492 histidinol dehydrogenase; Region: hisD; TIGR00069 1121335007493 NAD binding site [chemical binding]; other site 1121335007494 dimerization interface [polypeptide binding]; other site 1121335007495 product binding site; other site 1121335007496 substrate binding site [chemical binding]; other site 1121335007497 zinc binding site [ion binding]; other site 1121335007498 catalytic residues [active] 1121335007499 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1121335007500 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1121335007501 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1121335007502 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121335007503 dimer interface [polypeptide binding]; other site 1121335007504 motif 1; other site 1121335007505 active site 1121335007506 motif 2; other site 1121335007507 motif 3; other site 1121335007508 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1121335007509 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335007510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335007511 dimer interface [polypeptide binding]; other site 1121335007512 putative CheW interface [polypeptide binding]; other site 1121335007513 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1121335007514 putative FMN binding site [chemical binding]; other site 1121335007515 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121335007516 CAP-like domain; other site 1121335007517 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 1121335007518 active site 1121335007519 primary dimer interface [polypeptide binding]; other site 1121335007520 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1121335007521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335007522 Mg2+ binding site [ion binding]; other site 1121335007523 G-X-G motif; other site 1121335007524 DNA gyrase B; Region: DNA_gyraseB; pfam00204 1121335007525 ATP binding site [chemical binding]; other site 1121335007526 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1121335007527 active site 1121335007528 putative metal-binding site [ion binding]; other site 1121335007529 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121335007530 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1121335007531 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1121335007532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007533 Walker A motif; other site 1121335007534 ATP binding site [chemical binding]; other site 1121335007535 Walker B motif; other site 1121335007536 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121335007537 Clp protease; Region: CLP_protease; pfam00574 1121335007538 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121335007539 oligomer interface [polypeptide binding]; other site 1121335007540 active site residues [active] 1121335007541 trigger factor; Provisional; Region: tig; PRK01490 1121335007542 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121335007543 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1121335007544 S-layer homology domain; Region: SLH; pfam00395 1121335007545 S-layer homology domain; Region: SLH; pfam00395 1121335007546 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1121335007547 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335007548 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1121335007549 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335007550 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1121335007551 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1121335007552 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1121335007553 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1121335007554 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1121335007555 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1121335007556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335007557 ATP binding site [chemical binding]; other site 1121335007558 putative Mg++ binding site [ion binding]; other site 1121335007559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335007560 nucleotide binding region [chemical binding]; other site 1121335007561 ATP-binding site [chemical binding]; other site 1121335007562 TRCF domain; Region: TRCF; pfam03461 1121335007563 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121335007564 putative active site [active] 1121335007565 catalytic residue [active] 1121335007566 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1121335007567 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121335007568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007569 active site 1121335007570 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1121335007571 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1121335007572 Substrate binding site; other site 1121335007573 Mg++ binding site; other site 1121335007574 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1121335007575 active site 1121335007576 substrate binding site [chemical binding]; other site 1121335007577 CoA binding site [chemical binding]; other site 1121335007578 SpoVG; Region: SpoVG; cl00915 1121335007579 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1121335007580 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121335007581 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335007582 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335007583 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1121335007584 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121335007585 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1121335007586 Part of AAA domain; Region: AAA_19; pfam13245 1121335007587 AAA domain; Region: AAA_14; pfam13173 1121335007588 Family description; Region: UvrD_C_2; pfam13538 1121335007589 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1121335007590 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1121335007591 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1121335007592 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1121335007593 PemK-like protein; Region: PemK; pfam02452 1121335007594 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1121335007595 alanine racemase; Reviewed; Region: alr; PRK00053 1121335007596 active site 1121335007597 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335007598 dimer interface [polypeptide binding]; other site 1121335007599 substrate binding site [chemical binding]; other site 1121335007600 catalytic residues [active] 1121335007601 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1121335007602 putative carbohydrate kinase; Provisional; Region: PRK10565 1121335007603 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1121335007604 putative substrate binding site [chemical binding]; other site 1121335007605 putative ATP binding site [chemical binding]; other site 1121335007606 Rubredoxin [Energy production and conversion]; Region: COG1773 1121335007607 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1121335007608 iron binding site [ion binding]; other site 1121335007609 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1121335007610 peptide binding site [polypeptide binding]; other site 1121335007611 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121335007612 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121335007613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335007614 Walker A/P-loop; other site 1121335007615 ATP binding site [chemical binding]; other site 1121335007616 Q-loop/lid; other site 1121335007617 ABC transporter signature motif; other site 1121335007618 Walker B; other site 1121335007619 D-loop; other site 1121335007620 H-loop/switch region; other site 1121335007621 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335007622 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335007623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335007624 Walker A/P-loop; other site 1121335007625 ATP binding site [chemical binding]; other site 1121335007626 Q-loop/lid; other site 1121335007627 ABC transporter signature motif; other site 1121335007628 Walker B; other site 1121335007629 D-loop; other site 1121335007630 H-loop/switch region; other site 1121335007631 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335007632 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335007633 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121335007634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007635 dimer interface [polypeptide binding]; other site 1121335007636 conserved gate region; other site 1121335007637 putative PBP binding loops; other site 1121335007638 ABC-ATPase subunit interface; other site 1121335007639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335007640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007641 dimer interface [polypeptide binding]; other site 1121335007642 conserved gate region; other site 1121335007643 putative PBP binding loops; other site 1121335007644 ABC-ATPase subunit interface; other site 1121335007645 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1121335007646 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1121335007647 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1121335007648 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1121335007649 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1121335007650 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121335007651 substrate binding site [chemical binding]; other site 1121335007652 ATP binding site [chemical binding]; other site 1121335007653 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121335007654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335007655 Walker A/P-loop; other site 1121335007656 ATP binding site [chemical binding]; other site 1121335007657 Q-loop/lid; other site 1121335007658 ABC transporter signature motif; other site 1121335007659 Walker B; other site 1121335007660 D-loop; other site 1121335007661 H-loop/switch region; other site 1121335007662 hypothetical protein; Provisional; Region: PRK05590 1121335007663 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1121335007664 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1121335007665 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1121335007666 active site 1121335007667 HIGH motif; other site 1121335007668 KMSK motif region; other site 1121335007669 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1121335007670 tRNA binding surface [nucleotide binding]; other site 1121335007671 anticodon binding site; other site 1121335007672 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1121335007673 glutamate racemase; Provisional; Region: PRK00865 1121335007674 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1121335007675 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121335007676 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1121335007677 Sporulation and spore germination; Region: Germane; pfam10646 1121335007678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1121335007679 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1121335007680 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335007681 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335007682 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335007683 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335007684 active site 1121335007685 metal binding site [ion binding]; metal-binding site 1121335007686 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1121335007687 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1121335007688 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1121335007689 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1121335007690 active site 1121335007691 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1121335007692 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121335007693 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121335007694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335007695 active site 1121335007696 catalytic tetrad [active] 1121335007697 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1121335007698 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1121335007699 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121335007700 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335007701 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1121335007702 inhibitor binding site; inhibition site 1121335007703 active site 1121335007704 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335007705 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335007706 Integrase core domain; Region: rve; pfam00665 1121335007707 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1121335007708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335007709 FeS/SAM binding site; other site 1121335007710 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1121335007711 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1121335007712 active site 1121335007713 homodimer interface [polypeptide binding]; other site 1121335007714 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1121335007715 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1121335007716 Mg++ binding site [ion binding]; other site 1121335007717 putative catalytic motif [active] 1121335007718 substrate binding site [chemical binding]; other site 1121335007719 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1121335007720 catalytic motif [active] 1121335007721 Zn binding site [ion binding]; other site 1121335007722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007723 active site 1121335007724 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1121335007725 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1121335007726 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1121335007727 active site 1121335007728 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1121335007729 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1121335007730 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335007731 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335007732 Walker A/P-loop; other site 1121335007733 ATP binding site [chemical binding]; other site 1121335007734 Q-loop/lid; other site 1121335007735 ABC transporter signature motif; other site 1121335007736 Walker B; other site 1121335007737 D-loop; other site 1121335007738 H-loop/switch region; other site 1121335007739 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335007740 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1121335007741 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1121335007742 putative ligand binding site [chemical binding]; other site 1121335007743 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335007744 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335007745 Walker A/P-loop; other site 1121335007746 ATP binding site [chemical binding]; other site 1121335007747 Q-loop/lid; other site 1121335007748 ABC transporter signature motif; other site 1121335007749 Walker B; other site 1121335007750 D-loop; other site 1121335007751 H-loop/switch region; other site 1121335007752 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335007753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335007754 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335007755 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335007756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335007757 TM-ABC transporter signature motif; other site 1121335007758 gamma-glutamyl kinase; Provisional; Region: PRK05429 1121335007759 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1121335007760 nucleotide binding site [chemical binding]; other site 1121335007761 homotetrameric interface [polypeptide binding]; other site 1121335007762 putative phosphate binding site [ion binding]; other site 1121335007763 putative allosteric binding site; other site 1121335007764 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121335007765 IHF dimer interface [polypeptide binding]; other site 1121335007766 IHF - DNA interface [nucleotide binding]; other site 1121335007767 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1121335007768 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1121335007769 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 1121335007770 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1121335007771 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1121335007772 FlaG protein; Region: FlaG; pfam03646 1121335007773 flagellin; Reviewed; Region: PRK08869 1121335007774 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121335007775 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121335007776 carbon storage regulator; Provisional; Region: PRK01712 1121335007777 flagellar assembly protein FliW; Provisional; Region: PRK13285 1121335007778 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1121335007779 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121335007780 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121335007781 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1121335007782 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335007783 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 1121335007784 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121335007785 metal ion-dependent adhesion site (MIDAS); other site 1121335007786 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335007787 FlgN protein; Region: FlgN; pfam05130 1121335007788 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1121335007789 flagellar operon protein TIGR03826; Region: YvyF 1121335007790 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121335007791 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007792 active site 1121335007793 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1121335007794 AAA domain; Region: AAA_30; pfam13604 1121335007795 Family description; Region: UvrD_C_2; pfam13538 1121335007796 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1121335007797 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121335007798 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335007799 Zn2+ binding site [ion binding]; other site 1121335007800 Mg2+ binding site [ion binding]; other site 1121335007801 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121335007802 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121335007803 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121335007804 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121335007805 Rubredoxin [Energy production and conversion]; Region: COG1773 1121335007806 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1121335007807 iron binding site [ion binding]; other site 1121335007808 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1121335007809 PAS domain; Region: PAS_9; pfam13426 1121335007810 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121335007811 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121335007812 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121335007813 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121335007814 substrate binding pocket [chemical binding]; other site 1121335007815 chain length determination region; other site 1121335007816 substrate-Mg2+ binding site; other site 1121335007817 catalytic residues [active] 1121335007818 aspartate-rich region 1; other site 1121335007819 active site lid residues [active] 1121335007820 aspartate-rich region 2; other site 1121335007821 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1121335007822 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1121335007823 TQO small subunit DoxD; Region: DoxD; pfam04173 1121335007824 Predicted integral membrane protein [Function unknown]; Region: COG5652 1121335007825 ferric uptake regulator; Provisional; Region: fur; PRK09462 1121335007826 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121335007827 metal binding site 2 [ion binding]; metal-binding site 1121335007828 putative DNA binding helix; other site 1121335007829 metal binding site 1 [ion binding]; metal-binding site 1121335007830 dimer interface [polypeptide binding]; other site 1121335007831 structural Zn2+ binding site [ion binding]; other site 1121335007832 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121335007833 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335007834 ABC-ATPase subunit interface; other site 1121335007835 dimer interface [polypeptide binding]; other site 1121335007836 putative PBP binding regions; other site 1121335007837 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121335007838 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1121335007839 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1121335007840 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121335007841 metal binding site [ion binding]; metal-binding site 1121335007842 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1121335007843 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1121335007844 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335007845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335007846 DNA binding residues [nucleotide binding] 1121335007847 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335007848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335007849 S-adenosylmethionine binding site [chemical binding]; other site 1121335007850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335007851 binding surface 1121335007852 TPR motif; other site 1121335007853 TPR repeat; Region: TPR_11; pfam13414 1121335007854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335007855 binding surface 1121335007856 TPR motif; other site 1121335007857 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335007858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335007859 binding surface 1121335007860 TPR motif; other site 1121335007861 TPR repeat; Region: TPR_11; pfam13414 1121335007862 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121335007863 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 1121335007864 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335007865 Walker A/P-loop; other site 1121335007866 ATP binding site [chemical binding]; other site 1121335007867 Q-loop/lid; other site 1121335007868 ABC transporter signature motif; other site 1121335007869 Walker B; other site 1121335007870 D-loop; other site 1121335007871 H-loop/switch region; other site 1121335007872 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 1121335007873 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335007874 Walker A/P-loop; other site 1121335007875 ATP binding site [chemical binding]; other site 1121335007876 Q-loop/lid; other site 1121335007877 ABC transporter signature motif; other site 1121335007878 Walker B; other site 1121335007879 D-loop; other site 1121335007880 H-loop/switch region; other site 1121335007881 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1121335007882 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1121335007883 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1121335007884 alphaNTD - beta interaction site [polypeptide binding]; other site 1121335007885 alphaNTD homodimer interface [polypeptide binding]; other site 1121335007886 alphaNTD - beta' interaction site [polypeptide binding]; other site 1121335007887 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1121335007888 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1121335007889 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1121335007890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335007891 RNA binding surface [nucleotide binding]; other site 1121335007892 30S ribosomal protein S11; Validated; Region: PRK05309 1121335007893 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1121335007894 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1121335007895 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1121335007896 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1121335007897 rRNA binding site [nucleotide binding]; other site 1121335007898 predicted 30S ribosome binding site; other site 1121335007899 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1121335007900 RNA binding site [nucleotide binding]; other site 1121335007901 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121335007902 active site 1121335007903 adenylate kinase; Reviewed; Region: adk; PRK00279 1121335007904 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1121335007905 AMP-binding site [chemical binding]; other site 1121335007906 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1121335007907 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1121335007908 SecY translocase; Region: SecY; pfam00344 1121335007909 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1121335007910 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1121335007911 23S rRNA binding site [nucleotide binding]; other site 1121335007912 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1121335007913 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1121335007914 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1121335007915 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1121335007916 5S rRNA interface [nucleotide binding]; other site 1121335007917 23S rRNA interface [nucleotide binding]; other site 1121335007918 L5 interface [polypeptide binding]; other site 1121335007919 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1121335007920 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121335007921 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121335007922 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1121335007923 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1121335007924 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1121335007925 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1121335007926 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1121335007927 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1121335007928 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1121335007929 RNA binding site [nucleotide binding]; other site 1121335007930 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1121335007931 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1121335007932 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1121335007933 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1121335007934 23S rRNA interface [nucleotide binding]; other site 1121335007935 putative translocon interaction site; other site 1121335007936 signal recognition particle (SRP54) interaction site; other site 1121335007937 L23 interface [polypeptide binding]; other site 1121335007938 trigger factor interaction site; other site 1121335007939 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1121335007940 23S rRNA interface [nucleotide binding]; other site 1121335007941 5S rRNA interface [nucleotide binding]; other site 1121335007942 putative antibiotic binding site [chemical binding]; other site 1121335007943 L25 interface [polypeptide binding]; other site 1121335007944 L27 interface [polypeptide binding]; other site 1121335007945 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1121335007946 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1121335007947 G-X-X-G motif; other site 1121335007948 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1121335007949 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1121335007950 putative translocon binding site; other site 1121335007951 protein-rRNA interface [nucleotide binding]; other site 1121335007952 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1121335007953 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1121335007954 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1121335007955 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1121335007956 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1121335007957 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1121335007958 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1121335007959 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1121335007960 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1121335007961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335007962 Coenzyme A binding pocket [chemical binding]; other site 1121335007963 Glycoprotease family; Region: Peptidase_M22; pfam00814 1121335007964 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1121335007965 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1121335007966 Pectinesterase; Region: Pectinesterase; pfam01095 1121335007967 putative pectinesterase; Region: PLN02432; cl01911 1121335007968 Holin family; Region: Phage_holin_4; cl01989 1121335007969 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335007970 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335007971 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1121335007972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335007973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007974 dimer interface [polypeptide binding]; other site 1121335007975 conserved gate region; other site 1121335007976 ABC-ATPase subunit interface; other site 1121335007977 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335007978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007979 dimer interface [polypeptide binding]; other site 1121335007980 conserved gate region; other site 1121335007981 ABC-ATPase subunit interface; other site 1121335007982 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335007983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335007984 active site 1121335007985 phosphorylation site [posttranslational modification] 1121335007986 intermolecular recognition site; other site 1121335007987 dimerization interface [polypeptide binding]; other site 1121335007988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335007989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335007990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335007991 HAMP domain; Region: HAMP; pfam00672 1121335007992 dimerization interface [polypeptide binding]; other site 1121335007993 Histidine kinase; Region: His_kinase; pfam06580 1121335007994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335007995 ATP binding site [chemical binding]; other site 1121335007996 Mg2+ binding site [ion binding]; other site 1121335007997 G-X-G motif; other site 1121335007998 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335007999 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335008000 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 1121335008001 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335008002 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335008003 Rubrerythrin [Energy production and conversion]; Region: COG1592 1121335008004 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1121335008005 binuclear metal center [ion binding]; other site 1121335008006 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1121335008007 iron binding site [ion binding]; other site 1121335008008 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1121335008009 active site 1121335008010 catalytic triad [active] 1121335008011 oxyanion hole [active] 1121335008012 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1121335008013 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1121335008014 active site 1121335008015 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1121335008016 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1121335008017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335008018 Walker A motif; other site 1121335008019 ATP binding site [chemical binding]; other site 1121335008020 Walker B motif; other site 1121335008021 arginine finger; other site 1121335008022 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121335008023 elongation factor Tu; Reviewed; Region: PRK00049 1121335008024 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1121335008025 G1 box; other site 1121335008026 GEF interaction site [polypeptide binding]; other site 1121335008027 GTP/Mg2+ binding site [chemical binding]; other site 1121335008028 Switch I region; other site 1121335008029 G2 box; other site 1121335008030 G3 box; other site 1121335008031 Switch II region; other site 1121335008032 G4 box; other site 1121335008033 G5 box; other site 1121335008034 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1121335008035 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1121335008036 Antibiotic Binding Site [chemical binding]; other site 1121335008037 elongation factor G; Reviewed; Region: PRK00007 1121335008038 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121335008039 G1 box; other site 1121335008040 putative GEF interaction site [polypeptide binding]; other site 1121335008041 GTP/Mg2+ binding site [chemical binding]; other site 1121335008042 Switch I region; other site 1121335008043 G2 box; other site 1121335008044 G3 box; other site 1121335008045 Switch II region; other site 1121335008046 G4 box; other site 1121335008047 G5 box; other site 1121335008048 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121335008049 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121335008050 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121335008051 30S ribosomal protein S7; Validated; Region: PRK05302 1121335008052 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1121335008053 S17 interaction site [polypeptide binding]; other site 1121335008054 S8 interaction site; other site 1121335008055 16S rRNA interaction site [nucleotide binding]; other site 1121335008056 streptomycin interaction site [chemical binding]; other site 1121335008057 23S rRNA interaction site [nucleotide binding]; other site 1121335008058 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1121335008059 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1121335008060 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121335008061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335008062 Walker A/P-loop; other site 1121335008063 ATP binding site [chemical binding]; other site 1121335008064 Q-loop/lid; other site 1121335008065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121335008066 ABC transporter; Region: ABC_tran_2; pfam12848 1121335008067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121335008068 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335008069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335008071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008072 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121335008073 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121335008074 ring oligomerisation interface [polypeptide binding]; other site 1121335008075 ATP/Mg binding site [chemical binding]; other site 1121335008076 stacking interactions; other site 1121335008077 hinge regions; other site 1121335008078 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121335008079 oligomerisation interface [polypeptide binding]; other site 1121335008080 mobile loop; other site 1121335008081 roof hairpin; other site 1121335008082 pantothenate kinase; Reviewed; Region: PRK13318 1121335008083 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 1121335008084 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1121335008085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335008086 putative DNA binding site [nucleotide binding]; other site 1121335008087 putative Zn2+ binding site [ion binding]; other site 1121335008088 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1121335008089 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1121335008090 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 1121335008091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121335008092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335008093 active site 1121335008094 phosphorylation site [posttranslational modification] 1121335008095 intermolecular recognition site; other site 1121335008096 dimerization interface [polypeptide binding]; other site 1121335008097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121335008098 DNA binding residues [nucleotide binding] 1121335008099 dimerization interface [polypeptide binding]; other site 1121335008100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121335008101 Histidine kinase; Region: HisKA_3; pfam07730 1121335008102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335008103 ATP binding site [chemical binding]; other site 1121335008104 Mg2+ binding site [ion binding]; other site 1121335008105 G-X-G motif; other site 1121335008106 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121335008107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335008108 motif II; other site 1121335008109 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1121335008110 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121335008111 ligand binding site [chemical binding]; other site 1121335008112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121335008113 TPR motif; other site 1121335008114 binding surface 1121335008115 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1121335008116 peptidase T-like protein; Region: PepT-like; TIGR01883 1121335008117 metal binding site [ion binding]; metal-binding site 1121335008118 putative dimer interface [polypeptide binding]; other site 1121335008119 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121335008120 trimer interface [polypeptide binding]; other site 1121335008121 active site 1121335008122 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121335008123 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121335008124 Collagenase; Region: DUF3656; pfam12392 1121335008125 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121335008126 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1121335008127 Cell division protein ZapA; Region: ZapA; pfam05164 1121335008128 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1121335008129 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1121335008130 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1121335008131 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1121335008132 RNA binding site [nucleotide binding]; other site 1121335008133 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1121335008134 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335008135 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1121335008136 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1121335008137 Asp23 family; Region: Asp23; cl00574 1121335008138 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1121335008139 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1121335008140 Walker A/P-loop; other site 1121335008141 ATP binding site [chemical binding]; other site 1121335008142 Q-loop/lid; other site 1121335008143 ABC transporter signature motif; other site 1121335008144 Walker B; other site 1121335008145 D-loop; other site 1121335008146 H-loop/switch region; other site 1121335008147 TOBE domain; Region: TOBE; pfam03459 1121335008148 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1121335008149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121335008150 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1121335008151 feedback inhibition sensing region; other site 1121335008152 homohexameric interface [polypeptide binding]; other site 1121335008153 nucleotide binding site [chemical binding]; other site 1121335008154 N-acetyl-L-glutamate binding site [chemical binding]; other site 1121335008155 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1121335008156 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1121335008157 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1121335008158 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1121335008159 substrate binding pocket [chemical binding]; other site 1121335008160 dimer interface [polypeptide binding]; other site 1121335008161 inhibitor binding site; inhibition site 1121335008162 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1121335008163 B12 binding site [chemical binding]; other site 1121335008164 cobalt ligand [ion binding]; other site 1121335008165 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1121335008166 FtsH Extracellular; Region: FtsH_ext; pfam06480 1121335008167 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1121335008168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335008169 Walker A motif; other site 1121335008170 ATP binding site [chemical binding]; other site 1121335008171 Walker B motif; other site 1121335008172 arginine finger; other site 1121335008173 Peptidase family M41; Region: Peptidase_M41; pfam01434 1121335008174 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1121335008175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335008176 active site 1121335008177 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1121335008178 Ligand Binding Site [chemical binding]; other site 1121335008179 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121335008180 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1121335008181 replicative DNA helicase; Region: DnaB; TIGR00665 1121335008182 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121335008183 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1121335008184 Walker A motif; other site 1121335008185 ATP binding site [chemical binding]; other site 1121335008186 Walker B motif; other site 1121335008187 DNA binding loops [nucleotide binding] 1121335008188 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1121335008189 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1121335008190 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1121335008191 MazG-like family; Region: MazG-like; pfam12643 1121335008192 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1121335008193 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1121335008194 Ligand Binding Site [chemical binding]; other site 1121335008195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335008196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008197 dimer interface [polypeptide binding]; other site 1121335008198 ABC-ATPase subunit interface; other site 1121335008199 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335008200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008201 dimer interface [polypeptide binding]; other site 1121335008202 conserved gate region; other site 1121335008203 ABC-ATPase subunit interface; other site 1121335008204 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335008205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335008206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008207 FOG: CBS domain [General function prediction only]; Region: COG0517 1121335008208 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1121335008209 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1121335008210 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1121335008211 dimerization interface [polypeptide binding]; other site 1121335008212 active site 1121335008213 L-aspartate oxidase; Provisional; Region: PRK06175 1121335008214 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1121335008215 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121335008216 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 1121335008217 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1121335008218 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1121335008219 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1121335008220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1121335008221 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1121335008222 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121335008223 glycerol kinase; Provisional; Region: glpK; PRK00047 1121335008224 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1121335008225 N- and C-terminal domain interface [polypeptide binding]; other site 1121335008226 active site 1121335008227 MgATP binding site [chemical binding]; other site 1121335008228 catalytic site [active] 1121335008229 metal binding site [ion binding]; metal-binding site 1121335008230 glycerol binding site [chemical binding]; other site 1121335008231 homotetramer interface [polypeptide binding]; other site 1121335008232 homodimer interface [polypeptide binding]; other site 1121335008233 FBP binding site [chemical binding]; other site 1121335008234 protein IIAGlc interface [polypeptide binding]; other site 1121335008235 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1121335008236 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1121335008237 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1121335008238 putative NAD(P) binding site [chemical binding]; other site 1121335008239 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1121335008240 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1121335008241 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335008242 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335008243 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121335008244 Walker A/P-loop; other site 1121335008245 ATP binding site [chemical binding]; other site 1121335008246 Q-loop/lid; other site 1121335008247 ABC transporter signature motif; other site 1121335008248 Walker B; other site 1121335008249 D-loop; other site 1121335008250 H-loop/switch region; other site 1121335008251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335008252 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335008253 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335008254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008255 ABC-ATPase subunit interface; other site 1121335008256 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335008257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008258 dimer interface [polypeptide binding]; other site 1121335008259 conserved gate region; other site 1121335008260 ABC-ATPase subunit interface; other site 1121335008261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335008262 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335008263 Walker A/P-loop; other site 1121335008264 ATP binding site [chemical binding]; other site 1121335008265 Q-loop/lid; other site 1121335008266 ABC transporter signature motif; other site 1121335008267 Walker B; other site 1121335008268 D-loop; other site 1121335008269 H-loop/switch region; other site 1121335008270 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335008271 FtsX-like permease family; Region: FtsX; pfam02687 1121335008272 FtsX-like permease family; Region: FtsX; pfam02687 1121335008273 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 1121335008274 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1121335008275 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1121335008276 active site 1121335008277 dimer interface [polypeptide binding]; other site 1121335008278 effector binding site; other site 1121335008279 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1121335008280 TSCPD domain; Region: TSCPD; pfam12637 1121335008281 hypothetical protein; Provisional; Region: PRK04164 1121335008282 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1121335008283 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1121335008284 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1121335008285 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1121335008286 HflX GTPase family; Region: HflX; cd01878 1121335008287 G1 box; other site 1121335008288 GTP/Mg2+ binding site [chemical binding]; other site 1121335008289 Switch I region; other site 1121335008290 G2 box; other site 1121335008291 G3 box; other site 1121335008292 Switch II region; other site 1121335008293 G4 box; other site 1121335008294 G5 box; other site 1121335008295 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335008296 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121335008297 FtsX-like permease family; Region: FtsX; pfam02687 1121335008298 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335008299 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335008300 Walker A/P-loop; other site 1121335008301 ATP binding site [chemical binding]; other site 1121335008302 Q-loop/lid; other site 1121335008303 ABC transporter signature motif; other site 1121335008304 Walker B; other site 1121335008305 D-loop; other site 1121335008306 H-loop/switch region; other site 1121335008307 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121335008308 carboxyltransferase (CT) interaction site; other site 1121335008309 biotinylation site [posttranslational modification]; other site 1121335008310 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121335008311 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1121335008312 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1121335008313 active site 1121335008314 dimer interface [polypeptide binding]; other site 1121335008315 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1121335008316 Amidohydrolase; Region: Amidohydro_2; pfam04909 1121335008317 active site 1121335008318 hypothetical protein; Provisional; Region: PRK02947 1121335008319 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1121335008320 putative active site [active] 1121335008321 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335008322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1121335008323 motif II; other site 1121335008324 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1121335008325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335008326 active site 1121335008327 motif I; other site 1121335008328 motif II; other site 1121335008329 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335008330 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1121335008331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008332 dimer interface [polypeptide binding]; other site 1121335008333 conserved gate region; other site 1121335008334 putative PBP binding loops; other site 1121335008335 ABC-ATPase subunit interface; other site 1121335008336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008337 dimer interface [polypeptide binding]; other site 1121335008338 conserved gate region; other site 1121335008339 putative PBP binding loops; other site 1121335008340 ABC-ATPase subunit interface; other site 1121335008341 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1121335008342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335008343 Walker A/P-loop; other site 1121335008344 ATP binding site [chemical binding]; other site 1121335008345 Q-loop/lid; other site 1121335008346 ABC transporter signature motif; other site 1121335008347 Walker B; other site 1121335008348 D-loop; other site 1121335008349 H-loop/switch region; other site 1121335008350 TOBE domain; Region: TOBE_2; pfam08402 1121335008351 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1121335008352 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121335008353 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121335008354 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1121335008355 active site 1121335008356 trimer interface [polypeptide binding]; other site 1121335008357 allosteric site; other site 1121335008358 active site lid [active] 1121335008359 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121335008360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335008361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335008362 DNA binding site [nucleotide binding] 1121335008363 domain linker motif; other site 1121335008364 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335008365 ligand binding site [chemical binding]; other site 1121335008366 dimerization interface [polypeptide binding]; other site 1121335008367 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1121335008368 dimerization interface [polypeptide binding]; other site 1121335008369 putative active cleft [active] 1121335008370 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1121335008371 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1121335008372 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121335008373 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121335008374 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121335008375 hinge; other site 1121335008376 active site 1121335008377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1121335008378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335008379 dimerization interface [polypeptide binding]; other site 1121335008380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335008381 dimer interface [polypeptide binding]; other site 1121335008382 phosphorylation site [posttranslational modification] 1121335008383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335008384 ATP binding site [chemical binding]; other site 1121335008385 Mg2+ binding site [ion binding]; other site 1121335008386 G-X-G motif; other site 1121335008387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335008388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335008389 active site 1121335008390 phosphorylation site [posttranslational modification] 1121335008391 intermolecular recognition site; other site 1121335008392 dimerization interface [polypeptide binding]; other site 1121335008393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335008394 DNA binding site [nucleotide binding] 1121335008395 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335008396 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121335008397 FtsX-like permease family; Region: FtsX; pfam02687 1121335008398 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121335008399 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121335008400 Yip1 domain; Region: Yip1; pfam04893 1121335008401 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335008402 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335008403 Walker A/P-loop; other site 1121335008404 ATP binding site [chemical binding]; other site 1121335008405 Q-loop/lid; other site 1121335008406 ABC transporter signature motif; other site 1121335008407 Walker B; other site 1121335008408 D-loop; other site 1121335008409 H-loop/switch region; other site 1121335008410 DNA gyrase subunit A; Validated; Region: PRK05560 1121335008411 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121335008412 CAP-like domain; other site 1121335008413 active site 1121335008414 primary dimer interface [polypeptide binding]; other site 1121335008415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008416 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008417 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008418 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008419 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008420 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008421 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1121335008422 ParB-like nuclease domain; Region: ParBc; pfam02195 1121335008423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335008424 non-specific DNA binding site [nucleotide binding]; other site 1121335008425 salt bridge; other site 1121335008426 sequence-specific DNA binding site [nucleotide binding]; other site 1121335008427 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1121335008428 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1121335008429 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1121335008430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335008431 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1121335008432 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1121335008433 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1121335008434 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1121335008435 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1121335008436 G1 box; other site 1121335008437 GTP/Mg2+ binding site [chemical binding]; other site 1121335008438 Switch I region; other site 1121335008439 G2 box; other site 1121335008440 Switch II region; other site 1121335008441 G3 box; other site 1121335008442 G4 box; other site 1121335008443 G5 box; other site 1121335008444 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1121335008445 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1121335008446 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1121335008447 G-X-X-G motif; other site 1121335008448 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1121335008449 RxxxH motif; other site 1121335008450 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1121335008451 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1121335008452 Haemolytic domain; Region: Haemolytic; pfam01809 1121335008453 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1121335008454 Ribosomal protein L34; Region: Ribosomal_L34; cl00370