-- dump date 20140619_045333 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1121335000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1121335000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1121335000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000004 Walker A motif; other site 1121335000005 ATP binding site [chemical binding]; other site 1121335000006 Walker B motif; other site 1121335000007 arginine finger; other site 1121335000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121335000009 DnaA box-binding interface [nucleotide binding]; other site 1121335000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1121335000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1121335000012 putative DNA binding surface [nucleotide binding]; other site 1121335000013 dimer interface [polypeptide binding]; other site 1121335000014 beta-clamp/clamp loader binding surface; other site 1121335000015 beta-clamp/translesion DNA polymerase binding surface; other site 1121335000016 recombination protein F; Reviewed; Region: recF; PRK00064 1121335000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000018 Walker A/P-loop; other site 1121335000019 ATP binding site [chemical binding]; other site 1121335000020 Q-loop/lid; other site 1121335000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000022 ABC transporter signature motif; other site 1121335000023 Walker B; other site 1121335000024 D-loop; other site 1121335000025 H-loop/switch region; other site 1121335000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1121335000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000028 ATP binding site [chemical binding]; other site 1121335000029 Mg2+ binding site [ion binding]; other site 1121335000030 G-X-G motif; other site 1121335000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1121335000032 anchoring element; other site 1121335000033 dimer interface [polypeptide binding]; other site 1121335000034 ATP binding site [chemical binding]; other site 1121335000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1121335000036 active site 1121335000037 putative metal-binding site [ion binding]; other site 1121335000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121335000039 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335000040 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335000041 Integrase core domain; Region: rve; pfam00665 1121335000042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121335000043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121335000044 P-loop; other site 1121335000045 Magnesium ion binding site [ion binding]; other site 1121335000046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121335000047 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1121335000048 ParB-like nuclease domain; Region: ParB; smart00470 1121335000049 seryl-tRNA synthetase; Provisional; Region: PRK05431 1121335000050 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1121335000051 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1121335000052 dimer interface [polypeptide binding]; other site 1121335000053 active site 1121335000054 motif 1; other site 1121335000055 motif 2; other site 1121335000056 motif 3; other site 1121335000057 hypothetical protein; Provisional; Region: PRK03881 1121335000058 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1121335000059 AMMECR1; Region: AMMECR1; pfam01871 1121335000060 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 1121335000061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335000062 FeS/SAM binding site; other site 1121335000063 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1121335000064 active site 1121335000065 8-oxo-dGMP binding site [chemical binding]; other site 1121335000066 nudix motif; other site 1121335000067 metal binding site [ion binding]; metal-binding site 1121335000068 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1121335000069 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1121335000070 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1121335000071 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1121335000072 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1121335000073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1121335000074 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1121335000075 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 1121335000076 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1121335000077 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1121335000078 Cl binding site [ion binding]; other site 1121335000079 oligomer interface [polypeptide binding]; other site 1121335000080 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1121335000081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335000082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335000083 DNA binding residues [nucleotide binding] 1121335000084 Putative zinc-finger; Region: zf-HC2; pfam13490 1121335000085 Sporulation and spore germination; Region: Germane; pfam10646 1121335000086 Tubby C 2; Region: Tub_2; cl02043 1121335000087 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1121335000088 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1121335000089 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1121335000090 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121335000091 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1121335000092 putative dimer interface [polypeptide binding]; other site 1121335000093 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1121335000094 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1121335000095 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1121335000096 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1121335000097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000098 Walker A/P-loop; other site 1121335000099 ATP binding site [chemical binding]; other site 1121335000100 Q-loop/lid; other site 1121335000101 ABC transporter signature motif; other site 1121335000102 Walker B; other site 1121335000103 D-loop; other site 1121335000104 H-loop/switch region; other site 1121335000105 DNA polymerase IV; Reviewed; Region: PRK03103 1121335000106 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121335000107 active site 1121335000108 DNA binding site [nucleotide binding] 1121335000109 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1121335000110 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1121335000111 homotrimer interaction site [polypeptide binding]; other site 1121335000112 putative active site [active] 1121335000113 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1121335000114 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1121335000115 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1121335000116 active site 1121335000117 FMN binding site [chemical binding]; other site 1121335000118 substrate binding site [chemical binding]; other site 1121335000119 putative catalytic residue [active] 1121335000120 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335000121 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335000122 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1121335000123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335000124 NAD(P) binding site [chemical binding]; other site 1121335000125 active site 1121335000126 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1121335000127 L-aspartate oxidase; Provisional; Region: PRK06175 1121335000128 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1121335000129 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1121335000130 Walker A/P-loop; other site 1121335000131 ATP binding site [chemical binding]; other site 1121335000132 Q-loop/lid; other site 1121335000133 ABC transporter signature motif; other site 1121335000134 Walker B; other site 1121335000135 D-loop; other site 1121335000136 H-loop/switch region; other site 1121335000137 NIL domain; Region: NIL; pfam09383 1121335000138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000139 dimer interface [polypeptide binding]; other site 1121335000140 conserved gate region; other site 1121335000141 ABC-ATPase subunit interface; other site 1121335000142 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1121335000143 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1121335000144 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335000145 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335000146 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1121335000147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335000148 DNA-binding site [nucleotide binding]; DNA binding site 1121335000149 FCD domain; Region: FCD; pfam07729 1121335000150 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121335000151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335000152 DNA-binding site [nucleotide binding]; DNA binding site 1121335000153 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1121335000154 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1121335000155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335000156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335000157 homodimer interface [polypeptide binding]; other site 1121335000158 catalytic residue [active] 1121335000159 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1121335000160 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1121335000161 peptide binding site [polypeptide binding]; other site 1121335000162 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335000163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000164 dimer interface [polypeptide binding]; other site 1121335000165 conserved gate region; other site 1121335000166 putative PBP binding loops; other site 1121335000167 ABC-ATPase subunit interface; other site 1121335000168 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121335000169 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335000170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000171 dimer interface [polypeptide binding]; other site 1121335000172 conserved gate region; other site 1121335000173 putative PBP binding loops; other site 1121335000174 ABC-ATPase subunit interface; other site 1121335000175 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335000176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335000177 Walker A/P-loop; other site 1121335000178 ATP binding site [chemical binding]; other site 1121335000179 Q-loop/lid; other site 1121335000180 ABC transporter signature motif; other site 1121335000181 Walker B; other site 1121335000182 D-loop; other site 1121335000183 H-loop/switch region; other site 1121335000184 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335000185 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1121335000186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335000187 Walker A/P-loop; other site 1121335000188 ATP binding site [chemical binding]; other site 1121335000189 Q-loop/lid; other site 1121335000190 ABC transporter signature motif; other site 1121335000191 Walker B; other site 1121335000192 D-loop; other site 1121335000193 H-loop/switch region; other site 1121335000194 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335000195 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1121335000196 homotrimer interaction site [polypeptide binding]; other site 1121335000197 putative active site [active] 1121335000198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121335000199 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1121335000200 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1121335000201 active site 1121335000202 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335000203 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335000204 dimerization interface [polypeptide binding]; other site 1121335000205 Histidine kinase; Region: His_kinase; pfam06580 1121335000206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000207 ATP binding site [chemical binding]; other site 1121335000208 Mg2+ binding site [ion binding]; other site 1121335000209 G-X-G motif; other site 1121335000210 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335000211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000212 active site 1121335000213 phosphorylation site [posttranslational modification] 1121335000214 intermolecular recognition site; other site 1121335000215 dimerization interface [polypeptide binding]; other site 1121335000216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000218 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000220 dimer interface [polypeptide binding]; other site 1121335000221 conserved gate region; other site 1121335000222 ABC-ATPase subunit interface; other site 1121335000223 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000225 dimer interface [polypeptide binding]; other site 1121335000226 conserved gate region; other site 1121335000227 putative PBP binding loops; other site 1121335000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335000229 ABC-ATPase subunit interface; other site 1121335000230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000231 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121335000232 5S rRNA interface [nucleotide binding]; other site 1121335000233 CTC domain interface [polypeptide binding]; other site 1121335000234 L16 interface [polypeptide binding]; other site 1121335000235 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1121335000236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335000237 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1121335000238 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1121335000239 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1121335000240 active site 1121335000241 Substrate binding site; other site 1121335000242 Mg++ binding site; other site 1121335000243 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121335000244 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1121335000245 ATP cone domain; Region: ATP-cone; pfam03477 1121335000246 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1121335000247 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1121335000248 active site 1121335000249 Zn binding site [ion binding]; other site 1121335000250 glycine loop; other site 1121335000251 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1121335000252 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1121335000253 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121335000254 trimer interface [polypeptide binding]; other site 1121335000255 active site 1121335000256 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1121335000257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335000258 Coenzyme A binding pocket [chemical binding]; other site 1121335000259 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1121335000260 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1121335000261 O-Antigen ligase; Region: Wzy_C; pfam04932 1121335000262 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1121335000263 active site 1121335000264 dimer interfaces [polypeptide binding]; other site 1121335000265 catalytic residues [active] 1121335000266 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121335000267 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121335000268 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121335000269 nucleoside/Zn binding site; other site 1121335000270 dimer interface [polypeptide binding]; other site 1121335000271 catalytic motif [active] 1121335000272 Stage II sporulation protein; Region: SpoIID; pfam08486 1121335000273 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1121335000274 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 1121335000275 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121335000276 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121335000277 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1121335000278 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1121335000279 MreB and similar proteins; Region: MreB_like; cd10225 1121335000280 nucleotide binding site [chemical binding]; other site 1121335000281 putative protofilament interaction site [polypeptide binding]; other site 1121335000282 RodZ interaction site [polypeptide binding]; other site 1121335000283 Mg binding site [ion binding]; other site 1121335000284 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1121335000285 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121335000286 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1121335000287 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1121335000288 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121335000289 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335000290 Rod binding protein; Region: Rod-binding; cl01626 1121335000291 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335000292 S-layer homology domain; Region: SLH; pfam00395 1121335000293 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335000294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000295 Walker A/P-loop; other site 1121335000296 ATP binding site [chemical binding]; other site 1121335000297 Q-loop/lid; other site 1121335000298 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335000299 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1121335000300 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1121335000301 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335000302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335000303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000304 active site 1121335000305 phosphorylation site [posttranslational modification] 1121335000306 intermolecular recognition site; other site 1121335000307 dimerization interface [polypeptide binding]; other site 1121335000308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335000309 DNA binding site [nucleotide binding] 1121335000310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335000311 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121335000312 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335000313 dimerization interface [polypeptide binding]; other site 1121335000314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335000315 dimer interface [polypeptide binding]; other site 1121335000316 phosphorylation site [posttranslational modification] 1121335000317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335000318 ATP binding site [chemical binding]; other site 1121335000319 Mg2+ binding site [ion binding]; other site 1121335000320 G-X-G motif; other site 1121335000321 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1121335000322 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1121335000323 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1121335000324 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000326 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121335000327 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1121335000328 putative NAD(P) binding site [chemical binding]; other site 1121335000329 catalytic Zn binding site [ion binding]; other site 1121335000330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335000331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121335000332 active site 1121335000333 catalytic tetrad [active] 1121335000334 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1121335000335 glycogen branching enzyme; Provisional; Region: PRK05402 1121335000336 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1121335000337 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1121335000338 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1121335000339 active site 1121335000340 catalytic site [active] 1121335000341 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1121335000342 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000343 Interdomain contacts; other site 1121335000344 Cytokine receptor motif; other site 1121335000345 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000346 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000347 Interdomain contacts; other site 1121335000348 Cytokine receptor motif; other site 1121335000349 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000350 Interdomain contacts; other site 1121335000351 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000352 Interdomain contacts; other site 1121335000353 Cytokine receptor motif; other site 1121335000354 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335000355 Interdomain contacts; other site 1121335000356 Cytokine receptor motif; other site 1121335000357 S-layer homology domain; Region: SLH; pfam00395 1121335000358 S-layer homology domain; Region: SLH; pfam00395 1121335000359 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 1121335000360 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1121335000361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335000362 S-adenosylmethionine binding site [chemical binding]; other site 1121335000363 Pleckstrin homology-like domain; Region: PH-like; cl17171 1121335000364 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1121335000365 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1121335000366 spore coat protein YutH; Region: spore_yutH; TIGR02905 1121335000367 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1121335000368 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1121335000369 Potassium binding sites [ion binding]; other site 1121335000370 Cesium cation binding sites [ion binding]; other site 1121335000371 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1121335000372 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000374 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000376 dimer interface [polypeptide binding]; other site 1121335000377 conserved gate region; other site 1121335000378 putative PBP binding loops; other site 1121335000379 ABC-ATPase subunit interface; other site 1121335000380 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000382 dimer interface [polypeptide binding]; other site 1121335000383 conserved gate region; other site 1121335000384 ABC-ATPase subunit interface; other site 1121335000385 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1121335000386 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000387 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000388 S-layer homology domain; Region: SLH; pfam00395 1121335000389 S-layer homology domain; Region: SLH; pfam00395 1121335000390 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1121335000391 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1121335000392 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 1121335000393 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335000394 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1121335000395 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1121335000396 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1121335000397 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121335000398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335000399 DNA-binding site [nucleotide binding]; DNA binding site 1121335000400 FCD domain; Region: FCD; pfam07729 1121335000401 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1121335000402 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121335000403 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121335000404 dimer interface [polypeptide binding]; other site 1121335000405 ssDNA binding site [nucleotide binding]; other site 1121335000406 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121335000407 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1121335000408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335000409 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335000410 FeS/SAM binding site; other site 1121335000411 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1121335000412 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121335000413 putative NAD(P) binding site [chemical binding]; other site 1121335000414 active site 1121335000415 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121335000416 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121335000417 Ligand binding site; other site 1121335000418 Putative Catalytic site; other site 1121335000419 DXD motif; other site 1121335000420 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1121335000421 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1121335000422 FMN binding site [chemical binding]; other site 1121335000423 active site 1121335000424 catalytic residues [active] 1121335000425 substrate binding site [chemical binding]; other site 1121335000426 Bacterial Ig-like domain; Region: Big_5; pfam13205 1121335000427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1121335000428 O-Antigen ligase; Region: Wzy_C; pfam04932 1121335000429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335000430 TPR motif; other site 1121335000431 binding surface 1121335000432 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335000433 'predicted nonfunctional due to frameshift; predicted involved in regulation of cell wall biogenesis'; COG:0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; pyridoxal phosphate-dependent enzyme 1121335000434 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121335000435 or inactivated derivative; COG:3328 Transposase and inactivated derivatives; transposase 1121335000436 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1121335000437 LicD family; Region: LicD; pfam04991 1121335000438 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1121335000439 putative ADP-binding pocket [chemical binding]; other site 1121335000440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335000441 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1121335000442 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1121335000443 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335000444 MULE transposase domain; Region: MULE; pfam10551 1121335000445 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1121335000446 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121335000447 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121335000448 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1121335000449 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335000450 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1121335000451 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1121335000452 LicD family; Region: LicD; cl01378 1121335000453 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121335000454 substrate binding site; other site 1121335000455 dimer interface; other site 1121335000456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335000457 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121335000458 NAD(P) binding site [chemical binding]; other site 1121335000459 active site 1121335000460 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1121335000461 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121335000462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335000463 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1121335000464 active site 1121335000465 substrate binding site [chemical binding]; other site 1121335000466 S-layer homology domain; Region: SLH; pfam00395 1121335000467 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335000468 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335000469 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335000470 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335000471 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335000472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335000473 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335000474 binding surface 1121335000475 TPR motif; other site 1121335000476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335000477 binding surface 1121335000478 TPR motif; other site 1121335000479 TPR repeat; Region: TPR_11; pfam13414 1121335000480 histidine kinase- DNA gyrase B- and HSP90-like ATPase; COG:2972 Predicted signal transduction protein with a C-terminal ATPase domain; histidine kinase 1121335000481 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335000482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000483 active site 1121335000484 phosphorylation site [posttranslational modification] 1121335000485 intermolecular recognition site; other site 1121335000486 dimerization interface [polypeptide binding]; other site 1121335000487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000488 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1121335000489 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121335000490 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1121335000491 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1121335000492 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1121335000493 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1121335000494 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1121335000495 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121335000496 heterodimer interface [polypeptide binding]; other site 1121335000497 homodimer interface [polypeptide binding]; other site 1121335000498 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335000499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000500 Walker A motif; other site 1121335000501 ATP binding site [chemical binding]; other site 1121335000502 Walker B motif; other site 1121335000503 arginine finger; other site 1121335000504 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1121335000505 Protein of unknown function DUF58; Region: DUF58; pfam01882 1121335000506 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000507 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000508 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000509 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335000510 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335000511 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335000512 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1121335000513 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1121335000514 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121335000515 active site 1121335000516 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1121335000517 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121335000518 Active Sites [active] 1121335000519 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1121335000520 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1121335000521 CysD dimerization site [polypeptide binding]; other site 1121335000522 G1 box; other site 1121335000523 putative GEF interaction site [polypeptide binding]; other site 1121335000524 GTP/Mg2+ binding site [chemical binding]; other site 1121335000525 Switch I region; other site 1121335000526 G2 box; other site 1121335000527 G3 box; other site 1121335000528 Switch II region; other site 1121335000529 G4 box; other site 1121335000530 G5 box; other site 1121335000531 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1121335000532 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1121335000533 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1121335000534 Rrf2 family protein; Region: rrf2_super; TIGR00738 1121335000535 Transcriptional regulator; Region: Rrf2; pfam02082 1121335000536 COG:0775 Nucleoside phosphorylase; nucleoside phosphorylase 1121335000537 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1121335000538 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121335000539 SWIM zinc finger; Region: SWIM; pfam04434 1121335000540 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1121335000541 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1121335000542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335000543 ATP binding site [chemical binding]; other site 1121335000544 putative Mg++ binding site [ion binding]; other site 1121335000545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335000546 nucleotide binding region [chemical binding]; other site 1121335000547 ATP-binding site [chemical binding]; other site 1121335000548 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1121335000549 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121335000550 RF-1 domain; Region: RF-1; pfam00472 1121335000551 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1121335000552 Hemerythrin; Region: Hemerythrin; cd12107 1121335000553 Fe binding site [ion binding]; other site 1121335000554 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1121335000555 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1121335000556 metal binding site [ion binding]; metal-binding site 1121335000557 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335000558 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335000559 Integrase core domain; Region: rve; pfam00665 1121335000560 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335000561 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121335000562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335000563 FeS/SAM binding site; other site 1121335000564 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121335000565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335000566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335000567 putative substrate translocation pore; other site 1121335000568 with additional 4Fe4S-binding domain; COG:0535 Predicted Fe-S oxidoreductases; radical SAM protein 1121335000569 rhodanese-related; COG:0607 Rhodanese-related sulfurtransferase; sulfurtransferase 1121335000570 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000572 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000574 dimer interface [polypeptide binding]; other site 1121335000575 conserved gate region; other site 1121335000576 putative PBP binding loops; other site 1121335000577 ABC-ATPase subunit interface; other site 1121335000578 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335000581 ABC-ATPase subunit interface; other site 1121335000582 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1121335000583 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1121335000584 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121335000585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000586 active site 1121335000587 phosphorylation site [posttranslational modification] 1121335000588 intermolecular recognition site; other site 1121335000589 dimerization interface [polypeptide binding]; other site 1121335000590 CheB methylesterase; Region: CheB_methylest; pfam01339 1121335000591 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000593 dimer interface [polypeptide binding]; other site 1121335000594 conserved gate region; other site 1121335000595 ABC-ATPase subunit interface; other site 1121335000596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000598 dimer interface [polypeptide binding]; other site 1121335000599 conserved gate region; other site 1121335000600 putative PBP binding loops; other site 1121335000601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335000602 ABC-ATPase subunit interface; other site 1121335000603 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000604 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000608 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335000609 PHP domain; Region: PHP; pfam02811 1121335000610 active site 1121335000611 PHP-associated; Region: PHP_C; pfam13263 1121335000612 S-layer homology domain; Region: SLH; pfam00395 1121335000613 S-layer homology domain; Region: SLH; pfam00395 1121335000614 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121335000615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335000616 active site 1121335000617 phosphorylation site [posttranslational modification] 1121335000618 intermolecular recognition site; other site 1121335000619 dimerization interface [polypeptide binding]; other site 1121335000620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000621 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335000624 dimerization interface [polypeptide binding]; other site 1121335000625 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335000626 Histidine kinase; Region: His_kinase; pfam06580 1121335000627 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000628 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000629 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000631 dimer interface [polypeptide binding]; other site 1121335000632 conserved gate region; other site 1121335000633 putative PBP binding loops; other site 1121335000634 ABC-ATPase subunit interface; other site 1121335000635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000637 dimer interface [polypeptide binding]; other site 1121335000638 conserved gate region; other site 1121335000639 putative PBP binding loops; other site 1121335000640 ABC-ATPase subunit interface; other site 1121335000641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000643 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000645 dimer interface [polypeptide binding]; other site 1121335000646 conserved gate region; other site 1121335000647 ABC-ATPase subunit interface; other site 1121335000648 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000650 dimer interface [polypeptide binding]; other site 1121335000651 conserved gate region; other site 1121335000652 putative PBP binding loops; other site 1121335000653 ABC-ATPase subunit interface; other site 1121335000654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000655 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000657 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1121335000658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000660 dimer interface [polypeptide binding]; other site 1121335000661 conserved gate region; other site 1121335000662 putative PBP binding loops; other site 1121335000663 ABC-ATPase subunit interface; other site 1121335000664 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000666 dimer interface [polypeptide binding]; other site 1121335000667 conserved gate region; other site 1121335000668 putative PBP binding loops; other site 1121335000669 ABC-ATPase subunit interface; other site 1121335000670 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1121335000671 Amidohydrolase; Region: Amidohydro_2; pfam04909 1121335000672 active site 1121335000673 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121335000674 active site 1121335000675 Flavin Reductases; Region: FlaRed; cl00801 1121335000676 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1121335000677 CoenzymeA binding site [chemical binding]; other site 1121335000678 subunit interaction site [polypeptide binding]; other site 1121335000679 PHB binding site; other site 1121335000680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335000681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335000682 DNA binding site [nucleotide binding] 1121335000683 domain linker motif; other site 1121335000684 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335000685 ligand binding site [chemical binding]; other site 1121335000686 dimerization interface [polypeptide binding]; other site 1121335000687 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335000688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000689 dimer interface [polypeptide binding]; other site 1121335000690 conserved gate region; other site 1121335000691 ABC-ATPase subunit interface; other site 1121335000692 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335000693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335000694 dimer interface [polypeptide binding]; other site 1121335000695 ABC-ATPase subunit interface; other site 1121335000696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335000697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335000698 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1121335000699 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335000700 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335000701 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335000702 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1121335000703 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1121335000704 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1121335000705 TrkA-N domain; Region: TrkA_N; pfam02254 1121335000706 TrkA-C domain; Region: TrkA_C; pfam02080 1121335000707 TrkA-N domain; Region: TrkA_N; pfam02254 1121335000708 TrkA-C domain; Region: TrkA_C; pfam02080 1121335000709 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1121335000710 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121335000711 phospho-acceptor domain; COG:5002 Signal transduction histidine kinase; contains signal peptide; contains transmembrane domain; histidine kinase 1121335000712 SLH domain-containing protein 1121335000713 Probable beta-xylosidase; Provisional; Region: PLN03080 1121335000714 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335000715 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335000716 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335000717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000720 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1121335000721 ligand-binding site [chemical binding]; other site 1121335000722 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1121335000723 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1121335000724 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1121335000725 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 1121335000726 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121335000727 minor groove reading motif; other site 1121335000728 helix-hairpin-helix signature motif; other site 1121335000729 substrate binding pocket [chemical binding]; other site 1121335000730 active site 1121335000731 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1121335000732 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1121335000733 homodimer interface [polypeptide binding]; other site 1121335000734 metal binding site [ion binding]; metal-binding site 1121335000735 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1121335000736 homodimer interface [polypeptide binding]; other site 1121335000737 active site 1121335000738 putative chemical substrate binding site [chemical binding]; other site 1121335000739 metal binding site [ion binding]; metal-binding site 1121335000740 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335000741 RNA binding surface [nucleotide binding]; other site 1121335000742 YabP family; Region: YabP; cl06766 1121335000743 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 1121335000744 Predicted permeases [General function prediction only]; Region: COG0679 1121335000745 Septum formation initiator; Region: DivIC; pfam04977 1121335000746 serine O-acetyltransferase; Region: cysE; TIGR01172 1121335000747 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1121335000748 trimer interface [polypeptide binding]; other site 1121335000749 active site 1121335000750 substrate binding site [chemical binding]; other site 1121335000751 CoA binding site [chemical binding]; other site 1121335000752 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1121335000753 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121335000754 active site 1121335000755 HIGH motif; other site 1121335000756 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121335000757 KMSKS motif; other site 1121335000758 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1121335000759 tRNA binding surface [nucleotide binding]; other site 1121335000760 anticodon binding site; other site 1121335000761 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121335000762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335000763 dimer interface [polypeptide binding]; other site 1121335000764 putative CheW interface [polypeptide binding]; other site 1121335000765 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121335000766 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1121335000767 DXD motif; other site 1121335000768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1121335000769 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1121335000770 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 1121335000771 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1121335000772 DNA repair protein RadA; Provisional; Region: PRK11823 1121335000773 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1121335000774 Walker A motif/ATP binding site; other site 1121335000775 ATP binding site [chemical binding]; other site 1121335000776 Walker B motif; other site 1121335000777 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1121335000778 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 1121335000779 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1121335000780 putative active site [active] 1121335000781 TRAM domain; Region: TRAM; cl01282 1121335000782 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121335000783 substrate binding site; other site 1121335000784 dimer interface; other site 1121335000785 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1121335000786 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335000787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335000788 homodimer interface [polypeptide binding]; other site 1121335000789 catalytic residue [active] 1121335000790 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1121335000791 elongation factor G; Reviewed; Region: PRK12740 1121335000792 G1 box; other site 1121335000793 putative GEF interaction site [polypeptide binding]; other site 1121335000794 GTP/Mg2+ binding site [chemical binding]; other site 1121335000795 Switch I region; other site 1121335000796 G2 box; other site 1121335000797 G3 box; other site 1121335000798 Switch II region; other site 1121335000799 G4 box; other site 1121335000800 G5 box; other site 1121335000801 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121335000802 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121335000803 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121335000804 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1121335000805 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1121335000806 UvrB/uvrC motif; Region: UVR; pfam02151 1121335000807 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1121335000808 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1121335000809 ADP binding site [chemical binding]; other site 1121335000810 phosphagen binding site; other site 1121335000811 substrate specificity loop; other site 1121335000812 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1121335000813 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335000814 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335000815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000816 Walker A motif; other site 1121335000817 ATP binding site [chemical binding]; other site 1121335000818 Walker B motif; other site 1121335000819 arginine finger; other site 1121335000820 UvrB/uvrC motif; Region: UVR; pfam02151 1121335000821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335000822 Walker A motif; other site 1121335000823 ATP binding site [chemical binding]; other site 1121335000824 Walker B motif; other site 1121335000825 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121335000826 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1121335000827 23S rRNA interface [nucleotide binding]; other site 1121335000828 L3 interface [polypeptide binding]; other site 1121335000829 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1121335000830 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1121335000831 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121335000832 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335000833 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335000834 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121335000835 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1121335000836 Predicted membrane protein [Function unknown]; Region: COG3601 1121335000837 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1121335000838 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121335000839 Predicted membrane protein [Function unknown]; Region: COG2323 1121335000840 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121335000841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121335000842 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335000843 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121335000844 nucleotide binding site [chemical binding]; other site 1121335000845 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1121335000846 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1121335000847 dimerization interface 3.5A [polypeptide binding]; other site 1121335000848 active site 1121335000849 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1121335000850 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1121335000851 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121335000852 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121335000853 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121335000854 RPB1 interaction site [polypeptide binding]; other site 1121335000855 RPB10 interaction site [polypeptide binding]; other site 1121335000856 RPB11 interaction site [polypeptide binding]; other site 1121335000857 RPB3 interaction site [polypeptide binding]; other site 1121335000858 RPB12 interaction site [polypeptide binding]; other site 1121335000859 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1121335000860 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1121335000861 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1121335000862 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1121335000863 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1121335000864 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121335000865 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1121335000866 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1121335000867 G-loop; other site 1121335000868 DNA binding site [nucleotide binding] 1121335000869 TraX protein; Region: TraX; pfam05857 1121335000870 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121335000871 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1121335000872 putative ligand binding site [chemical binding]; other site 1121335000873 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 1121335000874 putative active site [active] 1121335000875 putative metal binding site [ion binding]; other site 1121335000876 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 1121335000877 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1121335000878 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1121335000879 homoserine dehydrogenase; Provisional; Region: PRK06349 1121335000880 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1121335000881 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1121335000882 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1121335000883 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335000884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335000885 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1121335000886 Walker A/P-loop; other site 1121335000887 ATP binding site [chemical binding]; other site 1121335000888 Q-loop/lid; other site 1121335000889 ABC transporter signature motif; other site 1121335000890 Walker B; other site 1121335000891 D-loop; other site 1121335000892 H-loop/switch region; other site 1121335000893 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335000894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335000895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335000896 Walker A/P-loop; other site 1121335000897 ATP binding site [chemical binding]; other site 1121335000898 Q-loop/lid; other site 1121335000899 ABC transporter signature motif; other site 1121335000900 Walker B; other site 1121335000901 D-loop; other site 1121335000902 H-loop/switch region; other site 1121335000903 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335000904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335000905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335000906 hypothetical protein; Validated; Region: PRK00153 1121335000907 recombination protein RecR; Reviewed; Region: recR; PRK00076 1121335000908 RecR protein; Region: RecR; pfam02132 1121335000909 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1121335000910 putative active site [active] 1121335000911 putative metal-binding site [ion binding]; other site 1121335000912 tetramer interface [polypeptide binding]; other site 1121335000913 AAA domain; Region: AAA_17; pfam13207 1121335000914 AAA domain; Region: AAA_18; pfam13238 1121335000915 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335000916 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121335000917 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1121335000918 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335000919 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1121335000920 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1121335000921 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 1121335000922 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1121335000923 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1121335000924 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1121335000925 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 1121335000926 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 1121335000927 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1121335000928 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1121335000929 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121335000930 Metal-binding active site; metal-binding site 1121335000931 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1121335000932 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1121335000933 putative ligand binding site [chemical binding]; other site 1121335000934 putative NAD binding site [chemical binding]; other site 1121335000935 catalytic site [active] 1121335000936 Probable beta-xylosidase; Provisional; Region: PLN03080 1121335000937 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335000938 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335000939 LysE type translocator; Region: LysE; pfam01810 1121335000940 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1121335000941 active site 1121335000942 tetramer interface; other site 1121335000943 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1121335000944 Maf-like protein; Region: Maf; pfam02545 1121335000945 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1121335000946 active site 1121335000947 dimer interface [polypeptide binding]; other site 1121335000948 rod shape-determining protein MreB; Provisional; Region: PRK13927 1121335000949 MreB and similar proteins; Region: MreB_like; cd10225 1121335000950 nucleotide binding site [chemical binding]; other site 1121335000951 Mg binding site [ion binding]; other site 1121335000952 putative protofilament interaction site [polypeptide binding]; other site 1121335000953 RodZ interaction site [polypeptide binding]; other site 1121335000954 rod shape-determining protein MreC; Provisional; Region: PRK13922 1121335000955 rod shape-determining protein MreC; Region: MreC; pfam04085 1121335000956 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1121335000957 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1121335000958 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121335000959 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121335000960 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1121335000961 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1121335000962 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1121335000963 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1121335000964 Switch I; other site 1121335000965 Switch II; other site 1121335000966 cell division topological specificity factor MinE; Provisional; Region: PRK13987 1121335000967 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1121335000968 substrate binding site [chemical binding]; other site 1121335000969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335000970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335000971 metal binding site [ion binding]; metal-binding site 1121335000972 active site 1121335000973 I-site; other site 1121335000974 V-type ATP synthase subunit I; Validated; Region: PRK05771 1121335000975 V-type ATP synthase subunit K; Validated; Region: PRK06558 1121335000976 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1121335000977 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1121335000978 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 1121335000979 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 1121335000980 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 1121335000981 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 1121335000982 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 1121335000983 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1121335000984 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335000985 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1121335000986 Walker A motif/ATP binding site; other site 1121335000987 Walker B motif; other site 1121335000988 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335000989 V-type ATP synthase subunit B; Provisional; Region: PRK04196 1121335000990 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335000991 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1121335000992 Walker A motif homologous position; other site 1121335000993 Walker B motif; other site 1121335000994 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335000995 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 1121335000996 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1121335000997 peptidase T; Region: peptidase-T; TIGR01882 1121335000998 metal binding site [ion binding]; metal-binding site 1121335000999 dimer interface [polypeptide binding]; other site 1121335001000 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1121335001001 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335001002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335001003 motif II; other site 1121335001004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001005 Walker A/P-loop; other site 1121335001006 ATP binding site [chemical binding]; other site 1121335001007 Q-loop/lid; other site 1121335001008 transglutaminase; Provisional; Region: tgl; PRK03187 1121335001009 YtxC-like family; Region: YtxC; pfam08812 1121335001010 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1121335001011 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1121335001012 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1121335001013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001014 Walker A/P-loop; other site 1121335001015 ATP binding site [chemical binding]; other site 1121335001016 Q-loop/lid; other site 1121335001017 ABC transporter signature motif; other site 1121335001018 Walker B; other site 1121335001019 D-loop; other site 1121335001020 H-loop/switch region; other site 1121335001021 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121335001022 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1121335001023 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1121335001024 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121335001025 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1121335001026 C-terminal peptidase (prc); Region: prc; TIGR00225 1121335001027 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1121335001028 protein binding site [polypeptide binding]; other site 1121335001029 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1121335001030 Catalytic dyad [active] 1121335001031 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1121335001032 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335001033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335001034 S-adenosylmethionine binding site [chemical binding]; other site 1121335001035 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1121335001036 DNA replication protein DnaC; Validated; Region: PRK06835 1121335001037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335001038 Walker A motif; other site 1121335001039 ATP binding site [chemical binding]; other site 1121335001040 Walker B motif; other site 1121335001041 arginine finger; other site 1121335001042 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1121335001043 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1121335001044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001045 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1121335001046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001047 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335001048 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1121335001049 active site 1121335001050 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335001051 Interdomain contacts; other site 1121335001052 Cytokine receptor motif; other site 1121335001053 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121335001054 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121335001055 hinge; other site 1121335001056 active site 1121335001057 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335001058 Zn2+ binding site [ion binding]; other site 1121335001059 Mg2+ binding site [ion binding]; other site 1121335001060 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1121335001061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335001062 Walker A motif; other site 1121335001063 ATP binding site [chemical binding]; other site 1121335001064 Walker B motif; other site 1121335001065 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121335001066 anti sigma factor interaction site; other site 1121335001067 regulatory phosphorylation site [posttranslational modification]; other site 1121335001068 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1121335001069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335001070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335001071 DNA binding site [nucleotide binding] 1121335001072 domain linker motif; other site 1121335001073 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335001074 dimerization interface [polypeptide binding]; other site 1121335001075 ligand binding site [chemical binding]; other site 1121335001076 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1121335001077 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 1121335001078 catalytic domain interface [polypeptide binding]; other site 1121335001079 homodimer interface [polypeptide binding]; other site 1121335001080 putative active site [active] 1121335001081 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335001082 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335001083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335001084 MULE transposase domain; Region: MULE; pfam10551 1121335001085 integron integrase; Region: integrase_gron; TIGR02249 1121335001086 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335001087 active site 1121335001088 DNA binding site [nucleotide binding] 1121335001089 Int/Topo IB signature motif; other site 1121335001090 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121335001091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335001092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335001093 non-specific DNA binding site [nucleotide binding]; other site 1121335001094 salt bridge; other site 1121335001095 sequence-specific DNA binding site [nucleotide binding]; other site 1121335001096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335001097 non-specific DNA binding site [nucleotide binding]; other site 1121335001098 salt bridge; other site 1121335001099 sequence-specific DNA binding site [nucleotide binding]; other site 1121335001100 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121335001101 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1121335001102 RecT family; Region: RecT; cl04285 1121335001103 Helix-turn-helix domain; Region: HTH_36; pfam13730 1121335001104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1121335001105 Walker A motif; other site 1121335001106 ATP binding site [chemical binding]; other site 1121335001107 Walker B motif; other site 1121335001108 arginine finger; other site 1121335001109 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1121335001110 putative active site [active] 1121335001111 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1121335001112 Terminase small subunit; Region: Terminase_2; pfam03592 1121335001113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335001114 MULE transposase domain; Region: MULE; pfam10551 1121335001115 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1121335001116 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1121335001117 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1121335001118 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1121335001119 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1121335001120 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1121335001121 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1121335001122 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1121335001123 Phage XkdN-like protein; Region: XkdN; pfam08890 1121335001124 Phage-related minor tail protein [Function unknown]; Region: COG5281 1121335001125 tape measure domain; Region: tape_meas_nterm; TIGR02675 1121335001126 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001127 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1121335001128 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1121335001129 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1121335001130 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1121335001131 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1121335001132 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1121335001133 amidase catalytic site [active] 1121335001134 Zn binding residues [ion binding]; other site 1121335001135 substrate binding site [chemical binding]; other site 1121335001136 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335001137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335001138 non-specific DNA binding site [nucleotide binding]; other site 1121335001139 salt bridge; other site 1121335001140 sequence-specific DNA binding site [nucleotide binding]; other site 1121335001141 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121335001142 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335001143 DNA binding site [nucleotide binding] 1121335001144 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1121335001145 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1121335001146 AAA domain; Region: AAA_21; pfam13304 1121335001147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001148 Walker B; other site 1121335001149 D-loop; other site 1121335001150 H-loop/switch region; other site 1121335001151 or inactivated derivative; COG:3464 Transposase and inactivated derivatives; transposase 1121335001152 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001153 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121335001154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335001155 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335001157 S-adenosylmethionine binding site [chemical binding]; other site 1121335001158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121335001159 catalytic core [active] 1121335001160 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1121335001161 Melibiase; Region: Melibiase; pfam02065 1121335001162 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1121335001163 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1121335001164 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121335001165 S-adenosylmethionine binding site [chemical binding]; other site 1121335001166 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121335001167 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121335001168 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121335001169 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1121335001170 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1121335001171 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1121335001172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335001173 ATP binding site [chemical binding]; other site 1121335001174 putative Mg++ binding site [ion binding]; other site 1121335001175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1121335001176 nucleotide binding region [chemical binding]; other site 1121335001177 ATP-binding site [chemical binding]; other site 1121335001178 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335001179 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1121335001180 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1121335001181 dimerization interface [polypeptide binding]; other site 1121335001182 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335001183 Histidine kinase; Region: His_kinase; pfam06580 1121335001184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001185 ATP binding site [chemical binding]; other site 1121335001186 Mg2+ binding site [ion binding]; other site 1121335001187 G-X-G motif; other site 1121335001188 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335001189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001190 active site 1121335001191 phosphorylation site [posttranslational modification] 1121335001192 intermolecular recognition site; other site 1121335001193 dimerization interface [polypeptide binding]; other site 1121335001194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001195 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1121335001196 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001197 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121335001198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335001199 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335001200 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001202 dimer interface [polypeptide binding]; other site 1121335001203 conserved gate region; other site 1121335001204 ABC-ATPase subunit interface; other site 1121335001205 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001207 ABC-ATPase subunit interface; other site 1121335001208 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001209 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335001210 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1121335001211 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335001212 HSP70 interaction site [polypeptide binding]; other site 1121335001213 mannonate dehydratase; Provisional; Region: PRK03906 1121335001214 mannonate dehydratase; Region: uxuA; TIGR00695 1121335001215 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121335001216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001217 FeS/SAM binding site; other site 1121335001218 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121335001219 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1121335001220 putative ADP-ribose binding site [chemical binding]; other site 1121335001221 putative active site [active] 1121335001222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335001223 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335001224 DNA binding site [nucleotide binding] 1121335001225 domain linker motif; other site 1121335001226 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335001227 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001229 dimer interface [polypeptide binding]; other site 1121335001230 conserved gate region; other site 1121335001231 putative PBP binding loops; other site 1121335001232 ABC-ATPase subunit interface; other site 1121335001233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001234 dimer interface [polypeptide binding]; other site 1121335001235 conserved gate region; other site 1121335001236 putative PBP binding loops; other site 1121335001237 ABC-ATPase subunit interface; other site 1121335001238 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335001240 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001242 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1121335001243 active site 1121335001244 catalytic triad [active] 1121335001245 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1121335001246 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1121335001247 Substrate binding site [chemical binding]; other site 1121335001248 Leucine rich repeat; Region: LRR_8; pfam13855 1121335001249 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1121335001250 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1121335001251 S-layer homology domain; Region: SLH; pfam00395 1121335001252 S-layer homology domain; Region: SLH; pfam00395 1121335001253 S-layer homology domain; Region: SLH; pfam00395 1121335001254 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121335001255 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121335001256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335001257 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121335001258 active site 1121335001259 catalytic tetrad [active] 1121335001260 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335001261 active site 1121335001262 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121335001263 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1121335001264 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121335001265 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335001266 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335001267 Walker A/P-loop; other site 1121335001268 ATP binding site [chemical binding]; other site 1121335001269 Q-loop/lid; other site 1121335001270 ABC transporter signature motif; other site 1121335001271 Walker B; other site 1121335001272 D-loop; other site 1121335001273 H-loop/switch region; other site 1121335001274 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335001275 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335001276 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335001277 Walker A/P-loop; other site 1121335001278 ATP binding site [chemical binding]; other site 1121335001279 Q-loop/lid; other site 1121335001280 ABC transporter signature motif; other site 1121335001281 Walker B; other site 1121335001282 D-loop; other site 1121335001283 H-loop/switch region; other site 1121335001284 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335001285 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335001286 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335001287 TM-ABC transporter signature motif; other site 1121335001288 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335001289 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335001290 TM-ABC transporter signature motif; other site 1121335001291 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1121335001292 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1121335001293 ligand binding site [chemical binding]; other site 1121335001294 COG:0253 Diaminopimelate epimerase; diaminopimelate epimerase 1121335001295 CoA binding domain; Region: CoA_binding_2; pfam13380 1121335001296 SurA N-terminal domain; Region: SurA_N_3; cl07813 1121335001297 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1121335001298 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1121335001299 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1121335001300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335001301 dimerization interface [polypeptide binding]; other site 1121335001302 Histidine kinase; Region: His_kinase; pfam06580 1121335001303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001304 Mg2+ binding site [ion binding]; other site 1121335001305 G-X-G motif; other site 1121335001306 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001308 active site 1121335001309 phosphorylation site [posttranslational modification] 1121335001310 intermolecular recognition site; other site 1121335001311 dimerization interface [polypeptide binding]; other site 1121335001312 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335001313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001315 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001317 dimer interface [polypeptide binding]; other site 1121335001318 conserved gate region; other site 1121335001319 ABC-ATPase subunit interface; other site 1121335001320 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001322 dimer interface [polypeptide binding]; other site 1121335001323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335001324 ABC-ATPase subunit interface; other site 1121335001325 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335001326 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1121335001327 active site 1121335001328 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1121335001329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001330 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335001331 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335001332 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121335001333 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121335001334 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121335001335 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1121335001336 catalytic site [active] 1121335001337 FlxA-like protein; Region: FlxA; pfam14282 1121335001338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001339 RPEL repeat; Region: RPEL; cl15286 1121335001340 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001342 dimer interface [polypeptide binding]; other site 1121335001343 conserved gate region; other site 1121335001344 putative PBP binding loops; other site 1121335001345 ABC-ATPase subunit interface; other site 1121335001346 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001348 dimer interface [polypeptide binding]; other site 1121335001349 conserved gate region; other site 1121335001350 putative PBP binding loops; other site 1121335001351 ABC-ATPase subunit interface; other site 1121335001352 Bacterial Ig-like domain; Region: Big_5; pfam13205 1121335001353 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1121335001354 MG2 domain; Region: A2M_N; pfam01835 1121335001355 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1121335001356 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1121335001357 homodimer interface [polypeptide binding]; other site 1121335001358 substrate-cofactor binding pocket; other site 1121335001359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335001360 catalytic residue [active] 1121335001361 predicted nonfunctional due to frameshift; COG:1032 Fe-S oxidoreductase; radical SAM protein 1121335001362 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1121335001363 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1121335001364 homodimer interface [polypeptide binding]; other site 1121335001365 oligonucleotide binding site [chemical binding]; other site 1121335001366 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121335001367 metal binding site 2 [ion binding]; metal-binding site 1121335001368 putative DNA binding helix; other site 1121335001369 metal binding site 1 [ion binding]; metal-binding site 1121335001370 dimer interface [polypeptide binding]; other site 1121335001371 structural Zn2+ binding site [ion binding]; other site 1121335001372 peroxiredoxin; Region: AhpC; TIGR03137 1121335001373 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1121335001374 dimer interface [polypeptide binding]; other site 1121335001375 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1121335001376 catalytic triad [active] 1121335001377 peroxidatic and resolving cysteines [active] 1121335001378 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1121335001379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335001380 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1121335001381 catalytic residue [active] 1121335001382 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1121335001383 catalytic residues [active] 1121335001384 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1121335001385 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1121335001386 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1121335001387 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1121335001388 GTP1/OBG; Region: GTP1_OBG; pfam01018 1121335001389 Obg GTPase; Region: Obg; cd01898 1121335001390 G1 box; other site 1121335001391 GTP/Mg2+ binding site [chemical binding]; other site 1121335001392 Switch I region; other site 1121335001393 G2 box; other site 1121335001394 G3 box; other site 1121335001395 Switch II region; other site 1121335001396 G4 box; other site 1121335001397 G5 box; other site 1121335001398 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1121335001399 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1121335001400 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1121335001401 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1121335001402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001403 active site 1121335001404 phosphorylation site [posttranslational modification] 1121335001405 intermolecular recognition site; other site 1121335001406 LytTr DNA-binding domain; Region: LytTR; smart00850 1121335001407 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1121335001408 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1121335001409 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1121335001410 Trp docking motif [polypeptide binding]; other site 1121335001411 AP endonuclease family 2; Region: AP2Ec; smart00518 1121335001412 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121335001413 Metal-binding active site; metal-binding site 1121335001414 AP (apurinic/apyrimidinic) site pocket; other site 1121335001415 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1121335001416 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1121335001417 FAD binding pocket [chemical binding]; other site 1121335001418 FAD binding motif [chemical binding]; other site 1121335001419 phosphate binding motif [ion binding]; other site 1121335001420 beta-alpha-beta structure motif; other site 1121335001421 NAD binding pocket [chemical binding]; other site 1121335001422 Iron coordination center [ion binding]; other site 1121335001423 putative oxidoreductase; Provisional; Region: PRK12831 1121335001424 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335001425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335001426 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1121335001427 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1121335001428 trimer interface [polypeptide binding]; other site 1121335001429 active site 1121335001430 dimer interface [polypeptide binding]; other site 1121335001431 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121335001432 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121335001433 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121335001434 active site 1121335001435 elongation factor P; Validated; Region: PRK00529 1121335001436 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1121335001437 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1121335001438 RNA binding site [nucleotide binding]; other site 1121335001439 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1121335001440 RNA binding site [nucleotide binding]; other site 1121335001441 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1121335001442 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121335001443 Walker A motif; other site 1121335001444 ATP binding site [chemical binding]; other site 1121335001445 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1121335001446 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1121335001447 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1121335001448 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1121335001449 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1121335001450 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1121335001451 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1121335001452 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1121335001453 germination protease; Provisional; Region: PRK12362 1121335001454 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335001455 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335001456 active site 1121335001457 metal binding site [ion binding]; metal-binding site 1121335001458 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1121335001459 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1121335001460 nucleotide binding pocket [chemical binding]; other site 1121335001461 K-X-D-G motif; other site 1121335001462 catalytic site [active] 1121335001463 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1121335001464 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1121335001465 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1121335001466 Dimer interface [polypeptide binding]; other site 1121335001467 BRCT sequence motif; other site 1121335001468 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1121335001469 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1121335001470 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1121335001471 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1121335001472 NodB motif; other site 1121335001473 active site 1121335001474 catalytic site [active] 1121335001475 Cd binding site [ion binding]; other site 1121335001476 YabP family; Region: YabP; cl06766 1121335001477 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1121335001478 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1121335001479 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1121335001480 PhoH-like protein; Region: PhoH; pfam02562 1121335001481 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1121335001482 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1121335001483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335001484 Zn2+ binding site [ion binding]; other site 1121335001485 Mg2+ binding site [ion binding]; other site 1121335001486 metal-binding heat shock protein; Provisional; Region: PRK00016 1121335001487 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1121335001488 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1121335001489 Peptidase family M50; Region: Peptidase_M50; pfam02163 1121335001490 active site 1121335001491 putative substrate binding region [chemical binding]; other site 1121335001492 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1121335001493 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1121335001494 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1121335001495 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1121335001496 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1121335001497 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1121335001498 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1121335001499 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335001500 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1121335001501 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1121335001502 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1121335001503 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1121335001504 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1121335001505 FliG C-terminal domain; Region: FliG_C; pfam01706 1121335001506 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121335001507 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1121335001508 Flagellar assembly protein FliH; Region: FliH; pfam02108 1121335001509 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 1121335001510 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335001511 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1121335001512 Walker A motif/ATP binding site; other site 1121335001513 Walker B motif; other site 1121335001514 MgtE intracellular N domain; Region: MgtE_N; smart00924 1121335001515 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1121335001516 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1121335001517 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1121335001518 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 1121335001519 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1121335001520 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121335001521 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1121335001522 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335001523 Flagellar protein (FlbD); Region: FlbD; pfam06289 1121335001524 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1121335001525 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1121335001526 flagellar motor switch protein; Validated; Region: PRK08119 1121335001527 CheC-like family; Region: CheC; pfam04509 1121335001528 CheC-like family; Region: CheC; pfam04509 1121335001529 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1121335001530 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335001531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001532 active site 1121335001533 phosphorylation site [posttranslational modification] 1121335001534 intermolecular recognition site; other site 1121335001535 dimerization interface [polypeptide binding]; other site 1121335001536 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1121335001537 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1121335001538 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1121335001539 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1121335001540 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1121335001541 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1121335001542 B12 binding domain; Region: B12-binding; pfam02310 1121335001543 B12 binding site [chemical binding]; other site 1121335001544 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1121335001545 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 1121335001546 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1121335001547 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1121335001548 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335001549 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335001550 Walker A/P-loop; other site 1121335001551 ATP binding site [chemical binding]; other site 1121335001552 Q-loop/lid; other site 1121335001553 ABC transporter signature motif; other site 1121335001554 Walker B; other site 1121335001555 D-loop; other site 1121335001556 H-loop/switch region; other site 1121335001557 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335001558 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1121335001559 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335001560 active site 1121335001561 HIGH motif; other site 1121335001562 nucleotide binding site [chemical binding]; other site 1121335001563 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121335001564 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121335001565 active site 1121335001566 KMSKS motif; other site 1121335001567 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1121335001568 tRNA binding surface [nucleotide binding]; other site 1121335001569 anticodon binding site; other site 1121335001570 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121335001571 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1121335001572 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1121335001573 oligomer interface [polypeptide binding]; other site 1121335001574 active site 1121335001575 metal binding site [ion binding]; metal-binding site 1121335001576 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1121335001577 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1121335001578 oligomer interface [polypeptide binding]; other site 1121335001579 active site 1121335001580 metal binding site [ion binding]; metal-binding site 1121335001581 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1121335001582 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1121335001583 oligomer interface [polypeptide binding]; other site 1121335001584 active site 1121335001585 metal binding site [ion binding]; metal-binding site 1121335001586 Carbohydrate binding domain; Region: CBM_25; smart01066 1121335001587 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 1121335001588 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1121335001589 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1121335001590 catalytic residues [active] 1121335001591 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1121335001592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001595 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1121335001596 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121335001597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335001598 dimerization interface [polypeptide binding]; other site 1121335001599 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335001600 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335001601 dimer interface [polypeptide binding]; other site 1121335001602 putative CheW interface [polypeptide binding]; other site 1121335001603 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121335001604 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121335001605 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1121335001606 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1121335001607 Predicted transcriptional regulator [Transcription]; Region: COG4189 1121335001608 Helix-turn-helix domain; Region: HTH_20; pfam12840 1121335001609 dimerization interface [polypeptide binding]; other site 1121335001610 putative DNA binding site [nucleotide binding]; other site 1121335001611 putative Zn2+ binding site [ion binding]; other site 1121335001612 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1121335001613 metal binding site [ion binding]; metal-binding site 1121335001614 active site 1121335001615 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1121335001616 Interdomain contacts; other site 1121335001617 Cytokine receptor motif; other site 1121335001618 S-layer homology domain; Region: SLH; pfam00395 1121335001619 S-layer homology domain; Region: SLH; pfam00395 1121335001620 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1121335001621 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1121335001622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001623 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001625 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001626 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1121335001627 dimer interface [polypeptide binding]; other site 1121335001628 active site 1121335001629 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1121335001630 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1121335001631 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1121335001632 Spore germination protein; Region: Spore_permease; cl17796 1121335001633 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1121335001634 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335001635 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335001636 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335001637 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1121335001638 glycogen synthase; Provisional; Region: glgA; PRK00654 1121335001639 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1121335001640 ADP-binding pocket [chemical binding]; other site 1121335001641 homodimer interface [polypeptide binding]; other site 1121335001642 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121335001643 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1121335001644 dimer interface [polypeptide binding]; other site 1121335001645 active site 1121335001646 metal binding site [ion binding]; metal-binding site 1121335001647 glutathione binding site [chemical binding]; other site 1121335001648 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1121335001649 Part of AAA domain; Region: AAA_19; pfam13245 1121335001650 Family description; Region: UvrD_C_2; pfam13538 1121335001651 Oligomerisation domain; Region: Oligomerisation; pfam02410 1121335001652 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1121335001653 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1121335001654 HIGH motif; other site 1121335001655 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121335001656 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335001657 active site 1121335001658 KMSKS motif; other site 1121335001659 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1121335001660 tRNA binding surface [nucleotide binding]; other site 1121335001661 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1121335001662 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1121335001663 active site 1121335001664 dimer interface [polypeptide binding]; other site 1121335001665 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121335001666 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121335001667 acyl-activating enzyme (AAE) consensus motif; other site 1121335001668 putative active site [active] 1121335001669 putative AMP binding site [chemical binding]; other site 1121335001670 putative CoA binding site [chemical binding]; other site 1121335001671 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1121335001672 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1121335001673 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335001674 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 1121335001675 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1121335001676 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1121335001677 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 1121335001678 DRTGG domain; Region: DRTGG; pfam07085 1121335001679 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121335001680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001681 ATP binding site [chemical binding]; other site 1121335001682 Mg2+ binding site [ion binding]; other site 1121335001683 G-X-G motif; other site 1121335001684 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335001685 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335001686 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335001687 Putative Fe-S cluster; Region: FeS; cl17515 1121335001688 DRTGG domain; Region: DRTGG; pfam07085 1121335001689 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335001690 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1121335001691 active site 1121335001692 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121335001693 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1121335001694 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1121335001695 FAD binding pocket [chemical binding]; other site 1121335001696 FAD binding motif [chemical binding]; other site 1121335001697 phosphate binding motif [ion binding]; other site 1121335001698 beta-alpha-beta structure motif; other site 1121335001699 NAD binding pocket [chemical binding]; other site 1121335001700 Iron coordination center [ion binding]; other site 1121335001701 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1121335001702 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1121335001703 heterodimer interface [polypeptide binding]; other site 1121335001704 active site 1121335001705 FMN binding site [chemical binding]; other site 1121335001706 homodimer interface [polypeptide binding]; other site 1121335001707 substrate binding site [chemical binding]; other site 1121335001708 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121335001709 catalytic core [active] 1121335001710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335001711 active site 1121335001712 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1121335001713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335001714 S-adenosylmethionine binding site [chemical binding]; other site 1121335001715 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1121335001716 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1121335001717 lipoyl synthase; Provisional; Region: PRK05481 1121335001718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001719 FeS/SAM binding site; other site 1121335001720 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335001721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001724 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 1121335001725 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1121335001726 L-rhamnose isomerase; Provisional; Region: PRK01076 1121335001727 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1121335001728 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1121335001729 Isochorismatase family; Region: Isochorismatase; pfam00857 1121335001730 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1121335001731 catalytic triad [active] 1121335001732 conserved cis-peptide bond; other site 1121335001733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001734 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335001735 active site 1121335001736 phosphorylation site [posttranslational modification] 1121335001737 intermolecular recognition site; other site 1121335001738 dimerization interface [polypeptide binding]; other site 1121335001739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335001740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335001742 dimerization interface [polypeptide binding]; other site 1121335001743 Histidine kinase; Region: His_kinase; pfam06580 1121335001744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001745 ATP binding site [chemical binding]; other site 1121335001746 Mg2+ binding site [ion binding]; other site 1121335001747 G-X-G motif; other site 1121335001748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335001749 active site 1121335001750 phosphorylation site [posttranslational modification] 1121335001751 intermolecular recognition site; other site 1121335001752 dimerization interface [polypeptide binding]; other site 1121335001753 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335001754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335001755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335001757 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001759 dimer interface [polypeptide binding]; other site 1121335001760 conserved gate region; other site 1121335001761 putative PBP binding loops; other site 1121335001762 ABC-ATPase subunit interface; other site 1121335001763 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335001764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001765 dimer interface [polypeptide binding]; other site 1121335001766 conserved gate region; other site 1121335001767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335001768 ABC-ATPase subunit interface; other site 1121335001769 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1121335001770 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1121335001771 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 1121335001772 Ca binding site [ion binding]; other site 1121335001773 carbohydrate binding site [chemical binding]; other site 1121335001774 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1121335001775 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121335001776 dimer interface [polypeptide binding]; other site 1121335001777 motif 1; other site 1121335001778 active site 1121335001779 motif 2; other site 1121335001780 motif 3; other site 1121335001781 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1121335001782 anticodon binding site; other site 1121335001783 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121335001784 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121335001785 dimer interface [polypeptide binding]; other site 1121335001786 anticodon binding site; other site 1121335001787 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121335001788 homodimer interface [polypeptide binding]; other site 1121335001789 motif 1; other site 1121335001790 active site 1121335001791 motif 2; other site 1121335001792 GAD domain; Region: GAD; pfam02938 1121335001793 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121335001794 motif 3; other site 1121335001795 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121335001796 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121335001797 Catalytic site [active] 1121335001798 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1121335001799 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1121335001800 generic binding surface II; other site 1121335001801 generic binding surface I; other site 1121335001802 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1121335001803 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1121335001804 active site 1121335001805 putative PHP Thumb interface [polypeptide binding]; other site 1121335001806 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1121335001807 Trp repressor protein; Region: Trp_repressor; cl17266 1121335001808 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1121335001809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335001810 ATP binding site [chemical binding]; other site 1121335001811 putative Mg++ binding site [ion binding]; other site 1121335001812 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1121335001813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1121335001814 nucleotide binding region [chemical binding]; other site 1121335001815 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1121335001816 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335001817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335001818 6-phosphofructokinase; Provisional; Region: PRK14072 1121335001819 active site 1121335001820 ADP/pyrophosphate binding site [chemical binding]; other site 1121335001821 dimerization interface [polypeptide binding]; other site 1121335001822 allosteric effector site; other site 1121335001823 fructose-1,6-bisphosphate binding site; other site 1121335001824 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1121335001825 putative metal binding site [ion binding]; other site 1121335001826 Integral membrane protein DUF95; Region: DUF95; pfam01944 1121335001827 RDD family; Region: RDD; pfam06271 1121335001828 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1121335001829 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335001830 dimer interface [polypeptide binding]; other site 1121335001831 PYR/PP interface [polypeptide binding]; other site 1121335001832 TPP binding site [chemical binding]; other site 1121335001833 substrate binding site [chemical binding]; other site 1121335001834 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121335001835 Domain of unknown function; Region: EKR; pfam10371 1121335001836 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1121335001837 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1121335001838 TPP-binding site [chemical binding]; other site 1121335001839 dimer interface [polypeptide binding]; other site 1121335001840 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1121335001841 active site 1121335001842 putative catalytic site [active] 1121335001843 DNA binding site [nucleotide binding] 1121335001844 putative phosphate binding site [ion binding]; other site 1121335001845 metal binding site A [ion binding]; metal-binding site 1121335001846 AP binding site [nucleotide binding]; other site 1121335001847 metal binding site B [ion binding]; metal-binding site 1121335001848 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1121335001849 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1121335001850 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335001851 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1121335001852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335001853 motif II; other site 1121335001854 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1121335001855 KWG Leptospira-motif containing protein 1121335001856 Holin family; Region: Phage_holin_4; pfam05105 1121335001857 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1121335001858 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335001859 DNA binding residues [nucleotide binding] 1121335001860 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335001861 PQQ-like domain; Region: PQQ_2; pfam13360 1121335001862 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1121335001863 Trp docking motif [polypeptide binding]; other site 1121335001864 active site 1121335001865 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1121335001866 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121335001867 transmembrane helices; other site 1121335001868 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1121335001869 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1121335001870 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1121335001871 dimer interface [polypeptide binding]; other site 1121335001872 active site 1121335001873 metal binding site [ion binding]; metal-binding site 1121335001874 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 1121335001875 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 1121335001876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001877 FeS/SAM binding site; other site 1121335001878 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1121335001879 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 1121335001880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335001881 FeS/SAM binding site; other site 1121335001882 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1121335001883 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1121335001884 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1121335001885 G1 box; other site 1121335001886 GTP/Mg2+ binding site [chemical binding]; other site 1121335001887 Switch I region; other site 1121335001888 G2 box; other site 1121335001889 Switch II region; other site 1121335001890 G3 box; other site 1121335001891 G4 box; other site 1121335001892 G5 box; other site 1121335001893 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335001894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335001895 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335001896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335001897 dimer interface [polypeptide binding]; other site 1121335001898 conserved gate region; other site 1121335001899 putative PBP binding loops; other site 1121335001900 ABC-ATPase subunit interface; other site 1121335001901 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335001902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335001903 TPR motif; other site 1121335001904 binding surface 1121335001905 Yip1 domain; Region: Yip1; pfam04893 1121335001906 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1121335001907 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1121335001908 COG:0395 ABC-type sugar transport system permease component; KEGG_module M00207:Putative multiple sugar transport system; KO:K02026 multiple sugar transport system permease protein; contains signal peptide; contains transmembrane domain; ABC transporter permease subunit 1121335001909 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1121335001910 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335001911 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1121335001912 active site 1121335001913 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1121335001914 substrate binding site [chemical binding]; other site 1121335001915 active site 1121335001916 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335001917 metal binding site [ion binding]; metal-binding site 1121335001918 ligand binding site [chemical binding]; other site 1121335001919 Rhomboid family; Region: Rhomboid; cl11446 1121335001920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335001921 dimerization interface [polypeptide binding]; other site 1121335001922 putative DNA binding site [nucleotide binding]; other site 1121335001923 putative Zn2+ binding site [ion binding]; other site 1121335001924 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121335001925 Heavy-metal-associated domain; Region: HMA; pfam00403 1121335001926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335001927 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335001928 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1121335001929 FHIPEP family; Region: FHIPEP; pfam00771 1121335001930 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1121335001931 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335001932 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1121335001933 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335001934 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121335001935 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1121335001936 PilZ domain; Region: PilZ; pfam07238 1121335001937 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121335001938 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121335001939 putative binding surface; other site 1121335001940 active site 1121335001941 P2 response regulator binding domain; Region: P2; pfam07194 1121335001942 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121335001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335001944 ATP binding site [chemical binding]; other site 1121335001945 Mg2+ binding site [ion binding]; other site 1121335001946 G-X-G motif; other site 1121335001947 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121335001948 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121335001949 putative CheA interaction surface; other site 1121335001950 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1121335001951 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121335001952 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1121335001953 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 1121335001954 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335001955 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335001956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335001957 DNA binding residues [nucleotide binding] 1121335001958 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121335001959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335001960 Zn2+ binding site [ion binding]; other site 1121335001961 Mg2+ binding site [ion binding]; other site 1121335001962 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1121335001963 dihydropteroate synthase; Region: DHPS; TIGR01496 1121335001964 substrate binding pocket [chemical binding]; other site 1121335001965 dimer interface [polypeptide binding]; other site 1121335001966 inhibitor binding site; inhibition site 1121335001967 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1121335001968 homooctamer interface [polypeptide binding]; other site 1121335001969 active site 1121335001970 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1121335001971 catalytic center binding site [active] 1121335001972 ATP binding site [chemical binding]; other site 1121335001973 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1121335001974 GTP cyclohydrolase I; Provisional; Region: PLN03044 1121335001975 active site 1121335001976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335001977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335001978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001979 Walker A/P-loop; other site 1121335001980 ATP binding site [chemical binding]; other site 1121335001981 Q-loop/lid; other site 1121335001982 ABC transporter signature motif; other site 1121335001983 Walker B; other site 1121335001984 D-loop; other site 1121335001985 H-loop/switch region; other site 1121335001986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335001987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335001988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335001989 Walker A/P-loop; other site 1121335001990 ATP binding site [chemical binding]; other site 1121335001991 Q-loop/lid; other site 1121335001992 ABC transporter signature motif; other site 1121335001993 Walker B; other site 1121335001994 D-loop; other site 1121335001995 H-loop/switch region; other site 1121335001996 predicted nonfunctional due to frameshift; COG:2059 Chromate transport protein ChrA; KO:K07240 chromate transporter; contains signal peptide; contains transmembrane domain; KO:K07240 chromate transporter; ChrA 1121335001997 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1121335001998 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335001999 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335002000 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1121335002001 SmpB-tmRNA interface; other site 1121335002002 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1121335002003 amidase catalytic site [active] 1121335002004 Zn binding residues [ion binding]; other site 1121335002005 substrate binding site [chemical binding]; other site 1121335002006 COG:0225 Peptide methionine sulfoxide reductase; KO:K07304 peptide-methionine S-S-oxide reductase; methionine-S-sulfoxide reductase 1121335002007 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1121335002008 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1121335002009 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1121335002010 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1121335002011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335002012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002013 dimer interface [polypeptide binding]; other site 1121335002014 conserved gate region; other site 1121335002015 putative PBP binding loops; other site 1121335002016 ABC-ATPase subunit interface; other site 1121335002017 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335002018 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121335002019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002020 dimer interface [polypeptide binding]; other site 1121335002021 conserved gate region; other site 1121335002022 putative PBP binding loops; other site 1121335002023 ABC-ATPase subunit interface; other site 1121335002024 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335002025 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002026 Walker A/P-loop; other site 1121335002027 ATP binding site [chemical binding]; other site 1121335002028 Q-loop/lid; other site 1121335002029 ABC transporter signature motif; other site 1121335002030 Walker B; other site 1121335002031 D-loop; other site 1121335002032 H-loop/switch region; other site 1121335002033 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121335002034 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121335002035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002036 Walker A/P-loop; other site 1121335002037 ATP binding site [chemical binding]; other site 1121335002038 Q-loop/lid; other site 1121335002039 ABC transporter signature motif; other site 1121335002040 Walker B; other site 1121335002041 D-loop; other site 1121335002042 H-loop/switch region; other site 1121335002043 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335002044 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121335002045 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121335002046 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121335002047 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1121335002048 active site 1121335002049 PAS fold; Region: PAS_4; pfam08448 1121335002050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335002051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002052 dimer interface [polypeptide binding]; other site 1121335002053 phosphorylation site [posttranslational modification] 1121335002054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002055 ATP binding site [chemical binding]; other site 1121335002056 Mg2+ binding site [ion binding]; other site 1121335002057 G-X-G motif; other site 1121335002058 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1121335002059 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1121335002060 putative active site [active] 1121335002061 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 1121335002062 Predicted transcriptional regulator [Transcription]; Region: COG3432 1121335002063 aconitate hydratase; Validated; Region: PRK07229 1121335002064 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 1121335002065 substrate binding site [chemical binding]; other site 1121335002066 ligand binding site [chemical binding]; other site 1121335002067 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 1121335002068 substrate binding site [chemical binding]; other site 1121335002069 isocitrate dehydrogenase; Validated; Region: PRK08299 1121335002070 GEMM cis-regulator; isocitrate dehydrogenase; Clst_0732 1121335002071 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121335002072 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335002073 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1121335002074 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335002075 RNA binding surface [nucleotide binding]; other site 1121335002076 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1121335002077 active site 1121335002078 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1121335002079 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1121335002080 dimer interface [polypeptide binding]; other site 1121335002081 active site 1121335002082 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1121335002083 folate binding site [chemical binding]; other site 1121335002084 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1121335002085 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1121335002086 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1121335002087 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1121335002088 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1121335002089 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121335002090 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335002091 Predicted membrane protein [Function unknown]; Region: COG1971 1121335002092 Domain of unknown function DUF; Region: DUF204; pfam02659 1121335002093 Domain of unknown function DUF; Region: DUF204; pfam02659 1121335002094 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1121335002095 ApbE family; Region: ApbE; pfam02424 1121335002096 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1121335002097 trimer interface [polypeptide binding]; other site 1121335002098 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 1121335002099 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1121335002100 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1121335002101 Y-family of DNA polymerases; Region: PolY; cl12025 1121335002102 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1121335002103 ssDNA binding site; other site 1121335002104 generic binding surface II; other site 1121335002105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335002106 ATP binding site [chemical binding]; other site 1121335002107 putative Mg++ binding site [ion binding]; other site 1121335002108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335002109 nucleotide binding region [chemical binding]; other site 1121335002110 ATP-binding site [chemical binding]; other site 1121335002111 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1121335002112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335002113 S-adenosylmethionine binding site [chemical binding]; other site 1121335002114 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1121335002115 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1121335002116 active site 1121335002117 (T/H)XGH motif; other site 1121335002118 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1121335002119 Nucleoside recognition; Region: Gate; pfam07670 1121335002120 Asp23 family; Region: Asp23; pfam03780 1121335002121 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335002122 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1121335002123 HSP70 interaction site [polypeptide binding]; other site 1121335002124 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335002125 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335002126 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335002127 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335002128 active site 1121335002129 metal binding site [ion binding]; metal-binding site 1121335002130 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1121335002131 MutS domain III; Region: MutS_III; pfam05192 1121335002132 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1121335002133 Walker A/P-loop; other site 1121335002134 ATP binding site [chemical binding]; other site 1121335002135 Q-loop/lid; other site 1121335002136 ABC transporter signature motif; other site 1121335002137 Walker B; other site 1121335002138 D-loop; other site 1121335002139 H-loop/switch region; other site 1121335002140 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1121335002141 Smr domain; Region: Smr; pfam01713 1121335002142 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 1121335002143 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335002144 dimer interface [polypeptide binding]; other site 1121335002145 PYR/PP interface [polypeptide binding]; other site 1121335002146 TPP binding site [chemical binding]; other site 1121335002147 substrate binding site [chemical binding]; other site 1121335002148 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1121335002149 TPP-binding site; other site 1121335002150 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1121335002151 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1121335002152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121335002153 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1121335002154 acyl-activating enzyme (AAE) consensus motif; other site 1121335002155 AMP binding site [chemical binding]; other site 1121335002156 active site 1121335002157 CoA binding site [chemical binding]; other site 1121335002158 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1121335002159 Family of unknown function (DUF633); Region: DUF633; pfam04816 1121335002160 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121335002161 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121335002162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1121335002163 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121335002164 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121335002165 Predicted transcriptional regulators [Transcription]; Region: COG1725 1121335002166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335002167 DNA-binding site [nucleotide binding]; DNA binding site 1121335002168 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121335002169 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335002170 Walker A/P-loop; other site 1121335002171 ATP binding site [chemical binding]; other site 1121335002172 Q-loop/lid; other site 1121335002173 ABC transporter signature motif; other site 1121335002174 Walker B; other site 1121335002175 D-loop; other site 1121335002176 H-loop/switch region; other site 1121335002177 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1121335002178 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1121335002179 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1121335002180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335002181 Coenzyme A binding pocket [chemical binding]; other site 1121335002182 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1121335002183 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1121335002184 active site 1121335002185 homodimer interface [polypeptide binding]; other site 1121335002186 Helix-hairpin-helix motif; Region: HHH; pfam00633 1121335002187 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1121335002188 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1121335002189 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1121335002190 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121335002191 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121335002192 active site 1121335002193 dimer interface [polypeptide binding]; other site 1121335002194 motif 1; other site 1121335002195 motif 2; other site 1121335002196 motif 3; other site 1121335002197 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121335002198 anticodon binding site; other site 1121335002199 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 1121335002200 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1121335002201 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335002202 active site 1121335002203 motif I; other site 1121335002204 motif II; other site 1121335002205 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1121335002206 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1121335002207 DJ-1 family protein; Region: not_thiJ; TIGR01383 1121335002208 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1121335002209 conserved cys residue [active] 1121335002210 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1121335002211 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1121335002212 Bacterial transcriptional regulator; Region: IclR; pfam01614 1121335002213 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1121335002214 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1121335002215 active site 1121335002216 intersubunit interface [polypeptide binding]; other site 1121335002217 catalytic residue [active] 1121335002218 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121335002219 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1121335002220 substrate binding site [chemical binding]; other site 1121335002221 ATP binding site [chemical binding]; other site 1121335002222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335002223 MULE transposase domain; Region: MULE; pfam10551 1121335002224 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121335002225 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335002226 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1121335002227 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121335002228 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335002229 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335002230 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121335002231 IMP binding site; other site 1121335002232 dimer interface [polypeptide binding]; other site 1121335002233 interdomain contacts; other site 1121335002234 partial ornithine binding site; other site 1121335002235 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121335002236 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002237 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002238 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1121335002239 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1121335002240 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1121335002241 catalytic site [active] 1121335002242 subunit interface [polypeptide binding]; other site 1121335002243 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1121335002244 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1121335002245 active site 1121335002246 tetramer interface [polypeptide binding]; other site 1121335002247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335002248 active site 1121335002249 contains transmembrane domain; hypothetical protein 1121335002250 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1121335002251 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1121335002252 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1121335002253 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121335002254 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121335002255 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1121335002256 putative active site [active] 1121335002257 putative metal binding residues [ion binding]; other site 1121335002258 signature motif; other site 1121335002259 putative dimer interface [polypeptide binding]; other site 1121335002260 putative phosphate binding site [ion binding]; other site 1121335002261 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335002262 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002264 dimer interface [polypeptide binding]; other site 1121335002265 conserved gate region; other site 1121335002266 putative PBP binding loops; other site 1121335002267 ABC-ATPase subunit interface; other site 1121335002268 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002270 dimer interface [polypeptide binding]; other site 1121335002271 conserved gate region; other site 1121335002272 ABC-ATPase subunit interface; other site 1121335002273 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121335002274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335002275 DNA-binding site [nucleotide binding]; DNA binding site 1121335002276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002277 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335002278 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1121335002279 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1121335002280 CAAX protease self-immunity; Region: Abi; pfam02517 1121335002281 S-layer homology domain; Region: SLH; pfam00395 1121335002282 S-layer homology domain; Region: SLH; pfam00395 1121335002283 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121335002284 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121335002285 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121335002286 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1121335002287 putative active site [active] 1121335002288 putative metal binding site [ion binding]; other site 1121335002289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335002290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002292 ABC-ATPase subunit interface; other site 1121335002293 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002295 dimer interface [polypeptide binding]; other site 1121335002296 conserved gate region; other site 1121335002297 putative PBP binding loops; other site 1121335002298 ABC-ATPase subunit interface; other site 1121335002299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002300 HAMP domain; Region: HAMP; pfam00672 1121335002301 Histidine kinase; Region: His_kinase; pfam06580 1121335002302 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1121335002303 ATP binding site [chemical binding]; other site 1121335002304 Mg2+ binding site [ion binding]; other site 1121335002305 G-X-G motif; other site 1121335002306 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335002307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002308 active site 1121335002309 phosphorylation site [posttranslational modification] 1121335002310 intermolecular recognition site; other site 1121335002311 dimerization interface [polypeptide binding]; other site 1121335002312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002315 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1121335002316 active site 1121335002317 catalytic residues [active] 1121335002318 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1121335002319 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1121335002320 NAD(P) binding site [chemical binding]; other site 1121335002321 LDH/MDH dimer interface [polypeptide binding]; other site 1121335002322 substrate binding site [chemical binding]; other site 1121335002323 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335002324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002327 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1121335002328 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1121335002329 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1121335002330 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1121335002331 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121335002332 Domain of unknown function DUF77; Region: DUF77; pfam01910 1121335002333 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002335 dimer interface [polypeptide binding]; other site 1121335002336 conserved gate region; other site 1121335002337 putative PBP binding loops; other site 1121335002338 ABC-ATPase subunit interface; other site 1121335002339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121335002340 NMT1/THI5 like; Region: NMT1; pfam09084 1121335002341 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335002342 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335002343 Walker A/P-loop; other site 1121335002344 ATP binding site [chemical binding]; other site 1121335002345 Q-loop/lid; other site 1121335002346 ABC transporter signature motif; other site 1121335002347 Walker B; other site 1121335002348 D-loop; other site 1121335002349 H-loop/switch region; other site 1121335002350 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1121335002351 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121335002352 DNA binding residues [nucleotide binding] 1121335002353 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1121335002354 Ferredoxin [Energy production and conversion]; Region: COG1146 1121335002355 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335002356 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121335002357 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1121335002358 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121335002359 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1121335002360 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121335002361 putative NAD(P) binding site [chemical binding]; other site 1121335002362 catalytic Zn binding site [ion binding]; other site 1121335002363 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1121335002364 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121335002365 E3 interaction surface; other site 1121335002366 lipoyl attachment site [posttranslational modification]; other site 1121335002367 e3 binding domain; Region: E3_binding; pfam02817 1121335002368 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1121335002369 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1121335002370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335002371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335002372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335002373 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121335002374 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1121335002375 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1121335002376 tetramer interface [polypeptide binding]; other site 1121335002377 TPP-binding site [chemical binding]; other site 1121335002378 heterodimer interface [polypeptide binding]; other site 1121335002379 phosphorylation loop region [posttranslational modification] 1121335002380 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1121335002381 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1121335002382 PYR/PP interface [polypeptide binding]; other site 1121335002383 dimer interface [polypeptide binding]; other site 1121335002384 TPP binding site [chemical binding]; other site 1121335002385 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335002386 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1121335002387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335002388 NAD(P) binding site [chemical binding]; other site 1121335002389 active site 1121335002390 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1121335002391 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1121335002392 active site 1121335002393 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1121335002394 N- and C-terminal domain interface [polypeptide binding]; other site 1121335002395 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1121335002396 active site 1121335002397 putative catalytic site [active] 1121335002398 metal binding site [ion binding]; metal-binding site 1121335002399 ATP binding site [chemical binding]; other site 1121335002400 carbohydrate binding site [chemical binding]; other site 1121335002401 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1121335002402 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121335002403 NlpC/P60 family; Region: NLPC_P60; cl17555 1121335002404 Restriction endonuclease; Region: Mrr_cat; pfam04471 1121335002405 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335002406 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335002407 Walker A/P-loop; other site 1121335002408 ATP binding site [chemical binding]; other site 1121335002409 Q-loop/lid; other site 1121335002410 ABC transporter signature motif; other site 1121335002411 Walker B; other site 1121335002412 D-loop; other site 1121335002413 H-loop/switch region; other site 1121335002414 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 1121335002415 CARDB; Region: CARDB; pfam07705 1121335002416 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335002417 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121335002418 FtsX-like permease family; Region: FtsX; pfam02687 1121335002419 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121335002420 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335002421 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121335002422 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121335002423 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 1121335002424 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121335002425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335002426 FeS/SAM binding site; other site 1121335002427 TRAM domain; Region: TRAM; pfam01938 1121335002428 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1121335002429 MutS domain I; Region: MutS_I; pfam01624 1121335002430 MutS domain II; Region: MutS_II; pfam05188 1121335002431 MutS domain III; Region: MutS_III; pfam05192 1121335002432 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1121335002433 Walker A/P-loop; other site 1121335002434 ATP binding site [chemical binding]; other site 1121335002435 Q-loop/lid; other site 1121335002436 ABC transporter signature motif; other site 1121335002437 Walker B; other site 1121335002438 D-loop; other site 1121335002439 H-loop/switch region; other site 1121335002440 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1121335002441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002442 ATP binding site [chemical binding]; other site 1121335002443 Mg2+ binding site [ion binding]; other site 1121335002444 G-X-G motif; other site 1121335002445 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1121335002446 ATP binding site [chemical binding]; other site 1121335002447 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1121335002448 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1121335002449 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1121335002450 bacterial Hfq-like; Region: Hfq; cd01716 1121335002451 hexamer interface [polypeptide binding]; other site 1121335002452 Sm1 motif; other site 1121335002453 RNA binding site [nucleotide binding]; other site 1121335002454 Sm2 motif; other site 1121335002455 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335002457 DNA binding site [nucleotide binding] 1121335002458 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335002459 ligand binding site [chemical binding]; other site 1121335002460 dimerization interface [polypeptide binding]; other site 1121335002461 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1121335002462 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1121335002463 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1121335002464 NADP binding site [chemical binding]; other site 1121335002465 homodimer interface [polypeptide binding]; other site 1121335002466 active site 1121335002467 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002469 dimer interface [polypeptide binding]; other site 1121335002470 conserved gate region; other site 1121335002471 ABC-ATPase subunit interface; other site 1121335002472 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002474 dimer interface [polypeptide binding]; other site 1121335002475 conserved gate region; other site 1121335002476 ABC-ATPase subunit interface; other site 1121335002477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335002478 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 1121335002479 substrate binding site [chemical binding]; other site 1121335002480 active site 1121335002481 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335002482 ligand binding site [chemical binding]; other site 1121335002483 metal binding site [ion binding]; metal-binding site 1121335002484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335002486 DNA binding site [nucleotide binding] 1121335002487 domain linker motif; other site 1121335002488 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335002489 dimerization interface [polypeptide binding]; other site 1121335002490 ligand binding site [chemical binding]; other site 1121335002491 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1121335002492 Carboxylesterase family; Region: COesterase; pfam00135 1121335002493 substrate binding pocket [chemical binding]; other site 1121335002494 catalytic triad [active] 1121335002495 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1121335002496 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1121335002497 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335002498 Double zinc ribbon; Region: DZR; pfam12773 1121335002499 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1121335002500 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335002501 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1121335002502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002503 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002505 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335002506 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1121335002507 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121335002508 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335002509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002510 dimer interface [polypeptide binding]; other site 1121335002511 conserved gate region; other site 1121335002512 putative PBP binding loops; other site 1121335002513 ABC-ATPase subunit interface; other site 1121335002514 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335002515 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1121335002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002517 dimer interface [polypeptide binding]; other site 1121335002518 conserved gate region; other site 1121335002519 putative PBP binding loops; other site 1121335002520 ABC-ATPase subunit interface; other site 1121335002521 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335002522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002523 Walker A/P-loop; other site 1121335002524 ATP binding site [chemical binding]; other site 1121335002525 Q-loop/lid; other site 1121335002526 ABC transporter signature motif; other site 1121335002527 Walker B; other site 1121335002528 D-loop; other site 1121335002529 H-loop/switch region; other site 1121335002530 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335002531 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121335002532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335002533 Walker A/P-loop; other site 1121335002534 ATP binding site [chemical binding]; other site 1121335002535 Q-loop/lid; other site 1121335002536 ABC transporter signature motif; other site 1121335002537 Walker B; other site 1121335002538 D-loop; other site 1121335002539 H-loop/switch region; other site 1121335002540 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335002541 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1121335002542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335002543 motif I; other site 1121335002544 active site 1121335002545 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1121335002546 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121335002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002548 active site 1121335002549 phosphorylation site [posttranslational modification] 1121335002550 intermolecular recognition site; other site 1121335002551 dimerization interface [polypeptide binding]; other site 1121335002552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335002553 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121335002554 putative active site [active] 1121335002555 heme pocket [chemical binding]; other site 1121335002556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335002557 putative active site [active] 1121335002558 heme pocket [chemical binding]; other site 1121335002559 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335002560 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121335002561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335002562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335002563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335002564 Walker A/P-loop; other site 1121335002565 ATP binding site [chemical binding]; other site 1121335002566 Q-loop/lid; other site 1121335002567 ABC transporter signature motif; other site 1121335002568 Walker B; other site 1121335002569 D-loop; other site 1121335002570 H-loop/switch region; other site 1121335002571 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335002572 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335002573 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335002574 Walker A/P-loop; other site 1121335002575 ATP binding site [chemical binding]; other site 1121335002576 Q-loop/lid; other site 1121335002577 ABC transporter signature motif; other site 1121335002578 Walker B; other site 1121335002579 D-loop; other site 1121335002580 H-loop/switch region; other site 1121335002581 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335002582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002583 active site 1121335002584 phosphorylation site [posttranslational modification] 1121335002585 intermolecular recognition site; other site 1121335002586 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335002587 DNA binding site [nucleotide binding] 1121335002588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335002590 dimer interface [polypeptide binding]; other site 1121335002591 phosphorylation site [posttranslational modification] 1121335002592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002593 ATP binding site [chemical binding]; other site 1121335002594 Mg2+ binding site [ion binding]; other site 1121335002595 G-X-G motif; other site 1121335002596 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121335002597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335002598 Walker A/P-loop; other site 1121335002599 ATP binding site [chemical binding]; other site 1121335002600 Q-loop/lid; other site 1121335002601 ABC transporter signature motif; other site 1121335002602 Walker B; other site 1121335002603 D-loop; other site 1121335002604 H-loop/switch region; other site 1121335002605 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1121335002606 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335002607 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1121335002608 N- and C-terminal domain interface [polypeptide binding]; other site 1121335002609 D-xylulose kinase; Region: XylB; TIGR01312 1121335002610 active site 1121335002611 MgATP binding site [chemical binding]; other site 1121335002612 catalytic site [active] 1121335002613 metal binding site [ion binding]; metal-binding site 1121335002614 xylulose binding site [chemical binding]; other site 1121335002615 homodimer interface [polypeptide binding]; other site 1121335002616 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1121335002617 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121335002618 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335002619 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121335002620 nucleotide binding site [chemical binding]; other site 1121335002621 xylose isomerase; Provisional; Region: PRK05474 1121335002622 xylose isomerase; Region: xylose_isom_A; TIGR02630 1121335002623 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1121335002624 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121335002625 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121335002626 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121335002627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335002628 catalytic residue [active] 1121335002629 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1121335002630 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1121335002631 trimerization site [polypeptide binding]; other site 1121335002632 active site 1121335002633 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1121335002634 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121335002635 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121335002636 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1121335002637 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1121335002638 Ligand Binding Site [chemical binding]; other site 1121335002639 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1121335002640 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121335002641 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1121335002642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335002643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335002644 DNA binding residues [nucleotide binding] 1121335002645 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1121335002646 intersubunit interface [polypeptide binding]; other site 1121335002647 active site 1121335002648 catalytic residue [active] 1121335002649 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335002650 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1121335002651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1121335002652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335002653 Coenzyme A binding pocket [chemical binding]; other site 1121335002654 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1121335002655 putative homodimer interface [polypeptide binding]; other site 1121335002656 putative active site pocket [active] 1121335002657 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121335002658 DivIVA protein; Region: DivIVA; pfam05103 1121335002659 Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; Region: ACE1-Sec16-like; cl14807 1121335002660 homodimer interface [polypeptide binding]; other site 1121335002661 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1121335002662 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1121335002663 AsnC family; Region: AsnC_trans_reg; pfam01037 1121335002664 hypothetical protein; Validated; Region: PRK07682 1121335002665 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335002666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002667 homodimer interface [polypeptide binding]; other site 1121335002668 catalytic residue [active] 1121335002669 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1121335002670 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1121335002671 NAD binding site [chemical binding]; other site 1121335002672 homotetramer interface [polypeptide binding]; other site 1121335002673 homodimer interface [polypeptide binding]; other site 1121335002674 substrate binding site [chemical binding]; other site 1121335002675 active site 1121335002676 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1121335002677 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335002678 Walker A/P-loop; other site 1121335002679 ATP binding site [chemical binding]; other site 1121335002680 Q-loop/lid; other site 1121335002681 ABC transporter signature motif; other site 1121335002682 Walker B; other site 1121335002683 D-loop; other site 1121335002684 H-loop/switch region; other site 1121335002685 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1121335002686 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1121335002687 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1121335002688 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1121335002689 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1121335002690 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1121335002691 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1121335002692 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1121335002693 putative dimer interface [polypeptide binding]; other site 1121335002694 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002697 ATP binding site [chemical binding]; other site 1121335002698 Mg2+ binding site [ion binding]; other site 1121335002699 G-X-G motif; other site 1121335002700 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335002701 dimer interface [polypeptide binding]; other site 1121335002702 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002703 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335002704 dimer interface [polypeptide binding]; other site 1121335002705 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002706 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1121335002707 SLBB domain; Region: SLBB; pfam10531 1121335002708 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1121335002709 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335002710 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335002711 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335002712 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121335002713 catalytic loop [active] 1121335002714 iron binding site [ion binding]; other site 1121335002715 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1121335002716 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1121335002717 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335002718 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335002719 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1121335002720 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1121335002721 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121335002722 5S rRNA interface [nucleotide binding]; other site 1121335002723 CTC domain interface [polypeptide binding]; other site 1121335002724 L16 interface [polypeptide binding]; other site 1121335002725 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1121335002726 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121335002727 Metal-binding active site; metal-binding site 1121335002728 AP (apurinic/apyrimidinic) site pocket; other site 1121335002729 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335002730 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1121335002731 active site 1121335002732 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1121335002733 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1121335002734 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1121335002735 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1121335002736 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121335002737 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121335002738 metal-binding site [ion binding] 1121335002739 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121335002740 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121335002741 metal-binding site [ion binding] 1121335002742 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335002743 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121335002744 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121335002745 metal-binding site [ion binding] 1121335002746 Predicted permeases [General function prediction only]; Region: COG0679 1121335002747 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1121335002748 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1121335002749 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1121335002750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335002751 DNA-binding site [nucleotide binding]; DNA binding site 1121335002752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335002753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002754 homodimer interface [polypeptide binding]; other site 1121335002755 catalytic residue [active] 1121335002756 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1121335002757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335002758 FeS/SAM binding site; other site 1121335002759 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1121335002760 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1121335002761 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1121335002762 putative dimer interface [polypeptide binding]; other site 1121335002763 putative anticodon binding site; other site 1121335002764 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1121335002765 homodimer interface [polypeptide binding]; other site 1121335002766 motif 1; other site 1121335002767 motif 2; other site 1121335002768 active site 1121335002769 motif 3; other site 1121335002770 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121335002771 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002772 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121335002773 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 1121335002774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335002775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002776 homodimer interface [polypeptide binding]; other site 1121335002777 catalytic residue [active] 1121335002778 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1121335002779 catalytic triad [active] 1121335002780 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1121335002781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335002782 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1121335002783 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1121335002784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335002785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335002786 DNA binding residues [nucleotide binding] 1121335002787 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1121335002788 DNA polymerase I; Provisional; Region: PRK05755 1121335002789 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1121335002790 active site 1121335002791 metal binding site 1 [ion binding]; metal-binding site 1121335002792 putative 5' ssDNA interaction site; other site 1121335002793 metal binding site 3; metal-binding site 1121335002794 metal binding site 2 [ion binding]; metal-binding site 1121335002795 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1121335002796 putative DNA binding site [nucleotide binding]; other site 1121335002797 putative metal binding site [ion binding]; other site 1121335002798 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1121335002799 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1121335002800 active site 1121335002801 DNA binding site [nucleotide binding] 1121335002802 catalytic site [active] 1121335002803 dephospho-CoA kinase; Region: TIGR00152 1121335002804 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1121335002805 CoA-binding site [chemical binding]; other site 1121335002806 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121335002807 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121335002808 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121335002809 catalytic residue [active] 1121335002810 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1121335002811 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1121335002812 intersubunit interface [polypeptide binding]; other site 1121335002813 active site 1121335002814 zinc binding site [ion binding]; other site 1121335002815 Na+ binding site [ion binding]; other site 1121335002816 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1121335002817 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335002818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335002819 active site 1121335002820 phosphorylation site [posttranslational modification] 1121335002821 intermolecular recognition site; other site 1121335002822 dimerization interface [polypeptide binding]; other site 1121335002823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335002824 DNA binding site [nucleotide binding] 1121335002825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335002826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335002827 dimer interface [polypeptide binding]; other site 1121335002828 phosphorylation site [posttranslational modification] 1121335002829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335002830 ATP binding site [chemical binding]; other site 1121335002831 Mg2+ binding site [ion binding]; other site 1121335002832 G-X-G motif; other site 1121335002833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335002834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335002835 DNA binding site [nucleotide binding] 1121335002836 domain linker motif; other site 1121335002837 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335002838 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335002839 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335002840 Integrase core domain; Region: rve; pfam00665 1121335002841 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1121335002842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002844 dimer interface [polypeptide binding]; other site 1121335002845 conserved gate region; other site 1121335002846 ABC-ATPase subunit interface; other site 1121335002847 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002849 dimer interface [polypeptide binding]; other site 1121335002850 conserved gate region; other site 1121335002851 putative PBP binding loops; other site 1121335002852 ABC-ATPase subunit interface; other site 1121335002853 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1121335002854 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121335002855 active site 1121335002856 catalytic site [active] 1121335002857 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121335002858 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121335002859 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1121335002860 homodimer interface [polypeptide binding]; other site 1121335002861 maltodextrin glucosidase; Provisional; Region: PRK10785 1121335002862 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1121335002863 active site 1121335002864 homodimer interface [polypeptide binding]; other site 1121335002865 catalytic site [active] 1121335002866 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121335002867 active site 1121335002868 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1121335002869 active site 2 [active] 1121335002870 active site 1 [active] 1121335002871 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1121335002872 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335002873 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335002874 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335002875 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1121335002876 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1121335002877 metal binding site [ion binding]; metal-binding site 1121335002878 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1121335002879 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1121335002880 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1121335002881 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1121335002882 lipoyl attachment site [posttranslational modification]; other site 1121335002883 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1121335002884 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1121335002885 tetramer interface [polypeptide binding]; other site 1121335002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002887 catalytic residue [active] 1121335002888 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1121335002889 tetramer interface [polypeptide binding]; other site 1121335002890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335002891 catalytic residue [active] 1121335002892 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1121335002893 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121335002894 dinuclear metal binding motif [ion binding]; other site 1121335002895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121335002896 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1121335002897 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1121335002898 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1121335002899 NAD(P) binding site [chemical binding]; other site 1121335002900 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121335002901 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121335002902 putative dimer interface [polypeptide binding]; other site 1121335002903 uracil-xanthine permease; Region: ncs2; TIGR00801 1121335002904 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121335002905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335002906 substrate binding pocket [chemical binding]; other site 1121335002907 membrane-bound complex binding site; other site 1121335002908 hinge residues; other site 1121335002909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002910 dimer interface [polypeptide binding]; other site 1121335002911 conserved gate region; other site 1121335002912 putative PBP binding loops; other site 1121335002913 ABC-ATPase subunit interface; other site 1121335002914 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121335002915 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121335002916 Walker A/P-loop; other site 1121335002917 ATP binding site [chemical binding]; other site 1121335002918 Q-loop/lid; other site 1121335002919 ABC transporter signature motif; other site 1121335002920 Walker B; other site 1121335002921 D-loop; other site 1121335002922 H-loop/switch region; other site 1121335002923 FOG: CBS domain [General function prediction only]; Region: COG0517 1121335002924 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1121335002925 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121335002926 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121335002927 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121335002928 Walker A/P-loop; other site 1121335002929 ATP binding site [chemical binding]; other site 1121335002930 Q-loop/lid; other site 1121335002931 ABC transporter signature motif; other site 1121335002932 Walker B; other site 1121335002933 D-loop; other site 1121335002934 H-loop/switch region; other site 1121335002935 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121335002936 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121335002937 Walker A/P-loop; other site 1121335002938 ATP binding site [chemical binding]; other site 1121335002939 Q-loop/lid; other site 1121335002940 ABC transporter signature motif; other site 1121335002941 Walker B; other site 1121335002942 D-loop; other site 1121335002943 H-loop/switch region; other site 1121335002944 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121335002945 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121335002946 TM-ABC transporter signature motif; other site 1121335002947 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335002948 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121335002949 TM-ABC transporter signature motif; other site 1121335002950 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121335002951 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1121335002952 putative ligand binding site [chemical binding]; other site 1121335002953 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1121335002954 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1121335002955 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1121335002956 Double zinc ribbon; Region: DZR; pfam12773 1121335002957 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1121335002958 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1121335002959 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1121335002960 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1121335002961 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1121335002962 [2Fe-2S] cluster binding site [ion binding]; other site 1121335002963 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1121335002964 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1121335002965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121335002966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121335002967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121335002968 dimerization interface [polypeptide binding]; other site 1121335002969 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1121335002970 active site 1121335002971 substrate-binding site [chemical binding]; other site 1121335002972 metal-binding site [ion binding] 1121335002973 GTP binding site [chemical binding]; other site 1121335002974 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335002975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002976 dimer interface [polypeptide binding]; other site 1121335002977 conserved gate region; other site 1121335002978 ABC-ATPase subunit interface; other site 1121335002979 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335002980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335002981 dimer interface [polypeptide binding]; other site 1121335002982 conserved gate region; other site 1121335002983 ABC-ATPase subunit interface; other site 1121335002984 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121335002985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335002986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335002987 zinc transporter ZupT; Provisional; Region: PRK04201 1121335002988 ZIP Zinc transporter; Region: Zip; pfam02535 1121335002989 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1121335002990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335002991 active site 1121335002992 catalytic tetrad [active] 1121335002993 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335002994 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1121335002995 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1121335002996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121335002997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121335002998 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121335002999 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121335003000 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121335003001 Protein export membrane protein; Region: SecD_SecF; cl14618 1121335003002 Protein export membrane protein; Region: SecD_SecF; cl14618 1121335003003 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335003004 PrcB C-terminal; Region: PrcB_C; pfam14343 1121335003005 PrcB C-terminal; Region: PrcB_C; pfam14343 1121335003006 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003007 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335003009 Walker A/P-loop; other site 1121335003010 ATP binding site [chemical binding]; other site 1121335003011 Q-loop/lid; other site 1121335003012 ABC transporter signature motif; other site 1121335003013 Walker B; other site 1121335003014 D-loop; other site 1121335003015 H-loop/switch region; other site 1121335003016 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003018 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335003019 Walker A/P-loop; other site 1121335003020 ATP binding site [chemical binding]; other site 1121335003021 Q-loop/lid; other site 1121335003022 ABC transporter signature motif; other site 1121335003023 Walker B; other site 1121335003024 D-loop; other site 1121335003025 H-loop/switch region; other site 1121335003026 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1121335003027 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1121335003028 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1121335003029 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335003030 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335003031 DNA binding site [nucleotide binding] 1121335003032 domain linker motif; other site 1121335003033 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335003034 dimerization interface [polypeptide binding]; other site 1121335003035 ligand binding site [chemical binding]; other site 1121335003036 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121335003037 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121335003038 NAD(P) binding site [chemical binding]; other site 1121335003039 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1121335003040 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1121335003041 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1121335003042 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335003043 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335003044 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121335003045 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1121335003046 active site 1121335003047 catalytic site [active] 1121335003048 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1121335003049 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1121335003050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335003052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003053 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003055 dimer interface [polypeptide binding]; other site 1121335003056 conserved gate region; other site 1121335003057 ABC-ATPase subunit interface; other site 1121335003058 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003060 dimer interface [polypeptide binding]; other site 1121335003061 ABC-ATPase subunit interface; other site 1121335003062 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003063 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335003064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335003065 sugar efflux transporter; Region: 2A0120; TIGR00899 1121335003066 putative substrate translocation pore; other site 1121335003067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121335003068 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1121335003069 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003070 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335003071 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1121335003072 active site 1121335003073 catalytic triad [active] 1121335003074 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335003075 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1121335003076 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1121335003077 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1121335003078 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1121335003079 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 1121335003080 hypothetical protein 1121335003081 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003083 dimer interface [polypeptide binding]; other site 1121335003084 conserved gate region; other site 1121335003085 putative PBP binding loops; other site 1121335003086 ABC-ATPase subunit interface; other site 1121335003087 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003089 dimer interface [polypeptide binding]; other site 1121335003090 ABC-ATPase subunit interface; other site 1121335003091 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 1121335003092 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1121335003093 transketolase; Reviewed; Region: PRK05899 1121335003094 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121335003095 TPP-binding site [chemical binding]; other site 1121335003096 dimer interface [polypeptide binding]; other site 1121335003097 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1121335003098 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121335003099 PYR/PP interface [polypeptide binding]; other site 1121335003100 dimer interface [polypeptide binding]; other site 1121335003101 TPP binding site [chemical binding]; other site 1121335003102 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335003103 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1121335003104 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003105 nucleotide binding site [chemical binding]; other site 1121335003106 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003107 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 1121335003108 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1121335003109 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121335003110 substrate binding site [chemical binding]; other site 1121335003111 trimer interface [polypeptide binding]; other site 1121335003112 Mn binding site [ion binding]; other site 1121335003113 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1121335003114 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1121335003115 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1121335003116 Trehalase; Region: Trehalase; cl17346 1121335003117 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335003118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335003119 DNA binding site [nucleotide binding] 1121335003120 domain linker motif; other site 1121335003121 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335003122 ligand binding site [chemical binding]; other site 1121335003123 dimerization interface [polypeptide binding]; other site 1121335003124 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1121335003125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335003126 DEAD_2; Region: DEAD_2; pfam06733 1121335003127 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1121335003128 Probable zinc-binding domain; Region: zf-trcl; pfam13451 1121335003129 hybrid cluster protein; Provisional; Region: PRK05290 1121335003130 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335003131 CODH interaction site; other site 1121335003132 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1121335003133 hybrid metal cluster; other site 1121335003134 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121335003135 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121335003136 ligand binding site [chemical binding]; other site 1121335003137 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1121335003138 putative switch regulator; other site 1121335003139 non-specific DNA interactions [nucleotide binding]; other site 1121335003140 DNA binding site [nucleotide binding] 1121335003141 sequence specific DNA binding site [nucleotide binding]; other site 1121335003142 putative cAMP binding site [chemical binding]; other site 1121335003143 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121335003144 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121335003145 acyl-activating enzyme (AAE) consensus motif; other site 1121335003146 putative active site [active] 1121335003147 putative AMP binding site [chemical binding]; other site 1121335003148 putative CoA binding site [chemical binding]; other site 1121335003149 GTP-binding protein YchF; Reviewed; Region: PRK09601 1121335003150 YchF GTPase; Region: YchF; cd01900 1121335003151 G1 box; other site 1121335003152 GTP/Mg2+ binding site [chemical binding]; other site 1121335003153 Switch I region; other site 1121335003154 G2 box; other site 1121335003155 Switch II region; other site 1121335003156 G3 box; other site 1121335003157 G4 box; other site 1121335003158 G5 box; other site 1121335003159 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1121335003160 PQQ-like domain; Region: PQQ_2; pfam13360 1121335003161 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1121335003162 YWTD domain; Region: YWTD; cl17223 1121335003163 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1121335003164 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1121335003165 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1121335003166 dimer interface [polypeptide binding]; other site 1121335003167 motif 1; other site 1121335003168 active site 1121335003169 motif 2; other site 1121335003170 motif 3; other site 1121335003171 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1121335003172 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1121335003173 putative tRNA-binding site [nucleotide binding]; other site 1121335003174 B3/4 domain; Region: B3_4; pfam03483 1121335003175 tRNA synthetase B5 domain; Region: B5; smart00874 1121335003176 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1121335003177 dimer interface [polypeptide binding]; other site 1121335003178 motif 1; other site 1121335003179 motif 3; other site 1121335003180 motif 2; other site 1121335003181 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1121335003182 hypothetical protein; Provisional; Region: PRK13670 1121335003183 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1121335003184 2-isopropylmalate synthase; Validated; Region: PRK03739 1121335003185 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1121335003186 active site 1121335003187 catalytic residues [active] 1121335003188 metal binding site [ion binding]; metal-binding site 1121335003189 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1121335003190 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1121335003191 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1121335003192 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335003193 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335003194 Integrase core domain; Region: rve; pfam00665 1121335003195 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1121335003196 Sm and related proteins; Region: Sm_like; cl00259 1121335003197 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1121335003198 putative oligomer interface [polypeptide binding]; other site 1121335003199 putative RNA binding site [nucleotide binding]; other site 1121335003200 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1121335003201 NusA N-terminal domain; Region: NusA_N; pfam08529 1121335003202 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1121335003203 RNA binding site [nucleotide binding]; other site 1121335003204 homodimer interface [polypeptide binding]; other site 1121335003205 NusA-like KH domain; Region: KH_5; pfam13184 1121335003206 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121335003207 G-X-X-G motif; other site 1121335003208 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1121335003209 putative RNA binding cleft [nucleotide binding]; other site 1121335003210 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1121335003211 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121335003212 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121335003213 translation initiation factor IF-2; Region: IF-2; TIGR00487 1121335003214 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1121335003215 G1 box; other site 1121335003216 putative GEF interaction site [polypeptide binding]; other site 1121335003217 GTP/Mg2+ binding site [chemical binding]; other site 1121335003218 Switch I region; other site 1121335003219 G2 box; other site 1121335003220 G3 box; other site 1121335003221 Switch II region; other site 1121335003222 G4 box; other site 1121335003223 G5 box; other site 1121335003224 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1121335003225 Translation-initiation factor 2; Region: IF-2; pfam11987 1121335003226 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1121335003227 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1121335003228 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121335003229 DHH family; Region: DHH; pfam01368 1121335003230 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 1121335003231 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1121335003232 RNA binding site [nucleotide binding]; other site 1121335003233 active site 1121335003234 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1121335003235 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1121335003236 active site 1121335003237 Riboflavin kinase; Region: Flavokinase; pfam01687 1121335003238 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1121335003239 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121335003240 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121335003241 PspC domain; Region: PspC; pfam04024 1121335003242 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1121335003243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335003244 active site 1121335003245 phosphorylation site [posttranslational modification] 1121335003246 intermolecular recognition site; other site 1121335003247 dimerization interface [polypeptide binding]; other site 1121335003248 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1121335003249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121335003250 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335003251 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1121335003252 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1121335003253 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121335003254 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121335003255 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121335003256 carboxyltransferase (CT) interaction site; other site 1121335003257 biotinylation site [posttranslational modification]; other site 1121335003258 oxaloacetate decarboxylase; Provisional; Region: PRK12331 1121335003259 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1121335003260 active site 1121335003261 catalytic residues [active] 1121335003262 metal binding site [ion binding]; metal-binding site 1121335003263 homodimer binding site [polypeptide binding]; other site 1121335003264 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1121335003265 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1121335003266 active site 1121335003267 dimer interface [polypeptide binding]; other site 1121335003268 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1121335003269 dimer interface [polypeptide binding]; other site 1121335003270 active site 1121335003271 phospho-acceptor domain/HAMP domain/histidine kinase- DNA gyrase B- and HSP90-like ATPase; COG:0642 Signal transduction histidine kinase; histidine kinase 1121335003272 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1121335003273 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1121335003274 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1121335003275 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1121335003276 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1121335003277 23S rRNA binding site [nucleotide binding]; other site 1121335003278 L21 binding site [polypeptide binding]; other site 1121335003279 L13 binding site [polypeptide binding]; other site 1121335003280 TIGR00159 family protein; Region: TIGR00159 1121335003281 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1121335003282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1121335003283 YbbR-like protein; Region: YbbR; pfam07949 1121335003284 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1121335003285 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121335003286 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1121335003287 PhoU domain; Region: PhoU; pfam01895 1121335003288 PhoU domain; Region: PhoU; pfam01895 1121335003289 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1121335003290 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1121335003291 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1121335003292 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1121335003293 active site 1121335003294 substrate binding site [chemical binding]; other site 1121335003295 metal binding site [ion binding]; metal-binding site 1121335003296 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121335003297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335003298 Coenzyme A binding pocket [chemical binding]; other site 1121335003299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1121335003300 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1121335003301 active site 1121335003302 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335003303 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1121335003304 substrate binding site [chemical binding]; other site 1121335003305 active site 1121335003306 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1121335003307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003310 dimer interface [polypeptide binding]; other site 1121335003311 conserved gate region; other site 1121335003312 putative PBP binding loops; other site 1121335003313 ABC-ATPase subunit interface; other site 1121335003314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003316 dimer interface [polypeptide binding]; other site 1121335003317 conserved gate region; other site 1121335003318 putative PBP binding loops; other site 1121335003319 ABC-ATPase subunit interface; other site 1121335003320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003321 binding surface 1121335003322 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121335003323 TPR motif; other site 1121335003324 Yip1 domain; Region: Yip1; pfam04893 1121335003325 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003327 dimer interface [polypeptide binding]; other site 1121335003328 conserved gate region; other site 1121335003329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335003330 ABC-ATPase subunit interface; other site 1121335003331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003333 dimer interface [polypeptide binding]; other site 1121335003334 conserved gate region; other site 1121335003335 putative PBP binding loops; other site 1121335003336 ABC-ATPase subunit interface; other site 1121335003337 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003338 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335003340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335003341 DNA binding site [nucleotide binding] 1121335003342 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335003343 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1121335003344 metal binding site [ion binding]; metal-binding site 1121335003345 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1121335003346 putative metal binding site [ion binding]; other site 1121335003347 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003348 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003349 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003351 dimer interface [polypeptide binding]; other site 1121335003352 conserved gate region; other site 1121335003353 putative PBP binding loops; other site 1121335003354 ABC-ATPase subunit interface; other site 1121335003355 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003357 dimer interface [polypeptide binding]; other site 1121335003358 conserved gate region; other site 1121335003359 ABC-ATPase subunit interface; other site 1121335003360 NHL repeat; Region: NHL; pfam01436 1121335003361 NHL repeat; Region: NHL; pfam01436 1121335003362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003363 binding surface 1121335003364 TPR repeat; Region: TPR_11; pfam13414 1121335003365 TPR motif; other site 1121335003366 Yip1 domain; Region: Yip1; pfam04893 1121335003367 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335003368 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1121335003369 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335003370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003371 dimer interface [polypeptide binding]; other site 1121335003372 conserved gate region; other site 1121335003373 ABC-ATPase subunit interface; other site 1121335003374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335003375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335003376 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1121335003377 putative metal binding site [ion binding]; other site 1121335003378 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1121335003379 Domain of unknown function (DUF377); Region: DUF377; pfam04041 1121335003380 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1121335003381 active site 1121335003382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121335003383 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121335003384 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1121335003385 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121335003386 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1121335003387 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1121335003388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1121335003389 NAD-dependent deacetylase; Provisional; Region: PRK00481 1121335003390 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1121335003391 NAD+ binding site [chemical binding]; other site 1121335003392 substrate binding site [chemical binding]; other site 1121335003393 Zn binding site [ion binding]; other site 1121335003394 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1121335003395 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121335003396 YGGT family; Region: YGGT; cl00508 1121335003397 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 1121335003398 dimer interface [polypeptide binding]; other site 1121335003399 Citrate synthase; Region: Citrate_synt; pfam00285 1121335003400 active site 1121335003401 citrylCoA binding site [chemical binding]; other site 1121335003402 oxalacetate/citrate binding site [chemical binding]; other site 1121335003403 coenzyme A binding site [chemical binding]; other site 1121335003404 catalytic triad [active] 1121335003405 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1121335003406 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121335003407 Walker A/P-loop; other site 1121335003408 ATP binding site [chemical binding]; other site 1121335003409 Q-loop/lid; other site 1121335003410 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1121335003411 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1121335003412 Q-loop/lid; other site 1121335003413 ABC transporter signature motif; other site 1121335003414 Walker B; other site 1121335003415 D-loop; other site 1121335003416 H-loop/switch region; other site 1121335003417 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1121335003418 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1121335003419 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121335003420 GTP binding site [chemical binding]; other site 1121335003421 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 1121335003422 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121335003423 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 1121335003424 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121335003425 active site 1121335003426 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1121335003427 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1121335003428 active site 1121335003429 YlzJ-like protein; Region: YlzJ; pfam14035 1121335003430 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1121335003431 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1121335003432 ligand binding site [chemical binding]; other site 1121335003433 NAD binding site [chemical binding]; other site 1121335003434 dimerization interface [polypeptide binding]; other site 1121335003435 catalytic site [active] 1121335003436 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1121335003437 putative L-serine binding site [chemical binding]; other site 1121335003438 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1121335003439 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121335003440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335003441 FeS/SAM binding site; other site 1121335003442 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1121335003443 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1121335003444 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1121335003445 active site 2 [active] 1121335003446 active site 1 [active] 1121335003447 putative phosphate acyltransferase; Provisional; Region: PRK05331 1121335003448 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1121335003449 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1121335003450 dimer interface [polypeptide binding]; other site 1121335003451 active site 1121335003452 CoA binding pocket [chemical binding]; other site 1121335003453 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121335003454 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121335003455 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1121335003456 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1121335003457 NAD(P) binding site [chemical binding]; other site 1121335003458 homotetramer interface [polypeptide binding]; other site 1121335003459 homodimer interface [polypeptide binding]; other site 1121335003460 active site 1121335003461 acyl carrier protein; Provisional; Region: acpP; PRK00982 1121335003462 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1121335003463 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1121335003464 dimer interface [polypeptide binding]; other site 1121335003465 active site 1121335003466 ribonuclease III; Reviewed; Region: rnc; PRK00102 1121335003467 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1121335003468 dimerization interface [polypeptide binding]; other site 1121335003469 active site 1121335003470 metal binding site [ion binding]; metal-binding site 1121335003471 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1121335003472 dsRNA binding site [nucleotide binding]; other site 1121335003473 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1121335003474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335003475 FeS/SAM binding site; other site 1121335003476 Fumble; Region: Fumble; cl17357 1121335003477 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1121335003478 Predicted membrane protein [Function unknown]; Region: COG4684 1121335003479 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1121335003480 fumarate hydratase; Provisional; Region: PRK06246 1121335003481 Predicted methyltransferases [General function prediction only]; Region: COG0313 1121335003482 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1121335003483 putative SAM binding site [chemical binding]; other site 1121335003484 putative homodimer interface [polypeptide binding]; other site 1121335003485 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1121335003486 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1121335003487 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1121335003488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335003489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335003490 active site 1121335003491 phosphorylation site [posttranslational modification] 1121335003492 intermolecular recognition site; other site 1121335003493 dimerization interface [polypeptide binding]; other site 1121335003494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335003495 DNA binding site [nucleotide binding] 1121335003496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335003497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335003498 dimerization interface [polypeptide binding]; other site 1121335003499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335003500 dimer interface [polypeptide binding]; other site 1121335003501 phosphorylation site [posttranslational modification] 1121335003502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335003503 ATP binding site [chemical binding]; other site 1121335003504 Mg2+ binding site [ion binding]; other site 1121335003505 G-X-G motif; other site 1121335003506 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335003507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335003508 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335003509 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121335003510 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121335003511 protein binding site [polypeptide binding]; other site 1121335003512 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1121335003513 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1121335003514 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1121335003515 dimerization interface [polypeptide binding]; other site 1121335003516 ATP binding site [chemical binding]; other site 1121335003517 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1121335003518 dimerization interface [polypeptide binding]; other site 1121335003519 ATP binding site [chemical binding]; other site 1121335003520 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1121335003521 putative active site [active] 1121335003522 catalytic triad [active] 1121335003523 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1121335003524 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1121335003525 VanW like protein; Region: VanW; pfam04294 1121335003526 Putative amidase domain; Region: Amidase_6; pfam12671 1121335003527 HEAT repeats; Region: HEAT_2; pfam13646 1121335003528 HEAT repeat; Region: HEAT; pfam02985 1121335003529 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335003530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1121335003531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1121335003532 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1121335003533 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121335003534 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1121335003535 S-layer homology domain; Region: SLH; pfam00395 1121335003536 S-layer homology domain; Region: SLH; pfam00395 1121335003537 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1121335003538 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121335003539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335003540 putative DNA binding site [nucleotide binding]; other site 1121335003541 putative Zn2+ binding site [ion binding]; other site 1121335003542 MarR family; Region: MarR_2; cl17246 1121335003543 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003544 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335003546 Walker A/P-loop; other site 1121335003547 ATP binding site [chemical binding]; other site 1121335003548 Q-loop/lid; other site 1121335003549 ABC transporter signature motif; other site 1121335003550 Walker B; other site 1121335003551 D-loop; other site 1121335003552 H-loop/switch region; other site 1121335003553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335003554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335003555 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335003556 Walker A/P-loop; other site 1121335003557 ATP binding site [chemical binding]; other site 1121335003558 Q-loop/lid; other site 1121335003559 ABC transporter signature motif; other site 1121335003560 Walker B; other site 1121335003561 D-loop; other site 1121335003562 H-loop/switch region; other site 1121335003563 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335003564 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1121335003565 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1121335003566 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1121335003567 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1121335003568 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1121335003569 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1121335003570 dimer interface [polypeptide binding]; other site 1121335003571 active site 1121335003572 catalytic residue [active] 1121335003573 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1121335003574 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121335003575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1121335003576 signal recognition particle protein; Provisional; Region: PRK10867 1121335003577 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1121335003578 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121335003579 P loop; other site 1121335003580 GTP binding site [chemical binding]; other site 1121335003581 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1121335003582 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1121335003583 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1121335003584 hypothetical protein; Provisional; Region: PRK00468 1121335003585 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121335003586 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121335003587 catalytic residues [active] 1121335003588 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 1121335003589 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1121335003590 active site 1121335003591 putative substrate binding pocket [chemical binding]; other site 1121335003592 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1121335003593 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1121335003594 Colicin V production protein; Region: Colicin_V; pfam02674 1121335003595 S-layer homology domain; Region: SLH; pfam00395 1121335003596 S-layer homology domain; Region: SLH; pfam00395 1121335003597 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1121335003598 C-terminal peptidase (prc); Region: prc; TIGR00225 1121335003599 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1121335003600 protein binding site [polypeptide binding]; other site 1121335003601 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1121335003602 Catalytic dyad [active] 1121335003603 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335003604 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1121335003605 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1121335003606 putative substrate binding site [chemical binding]; other site 1121335003607 putative ATP binding site [chemical binding]; other site 1121335003608 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1121335003609 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1121335003610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335003611 MULE transposase domain; Region: MULE; pfam10551 1121335003612 Integrase core domain; Region: rve; pfam00665 1121335003613 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335003614 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1121335003615 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335003616 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1121335003617 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335003618 metal binding site [ion binding]; metal-binding site 1121335003619 ligand binding site [chemical binding]; other site 1121335003620 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335003621 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335003622 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121335003623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335003624 Coenzyme A binding pocket [chemical binding]; other site 1121335003625 putative alpha-glucosidase; Provisional; Region: PRK10658 1121335003626 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1121335003627 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1121335003628 active site 1121335003629 homotrimer interface [polypeptide binding]; other site 1121335003630 catalytic site [active] 1121335003631 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1121335003632 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335003633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003634 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335003635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335003636 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 1121335003637 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1121335003638 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1121335003639 active site 1121335003640 (T/H)XGH motif; other site 1121335003641 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335003642 Zn2+ binding site [ion binding]; other site 1121335003643 Mg2+ binding site [ion binding]; other site 1121335003644 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121335003645 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121335003646 Catalytic site [active] 1121335003647 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335003648 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335003649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335003650 MULE transposase domain; Region: MULE; pfam10551 1121335003651 or inactivated derivative; COG:3328 Transposase and inactivated derivatives; transposase 1121335003652 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1121335003653 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121335003654 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335003655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335003656 non-specific DNA binding site [nucleotide binding]; other site 1121335003657 salt bridge; other site 1121335003658 sequence-specific DNA binding site [nucleotide binding]; other site 1121335003659 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 1121335003660 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003661 MULE transposase domain; Region: MULE; pfam10551 1121335003662 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1121335003663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335003664 non-specific DNA binding site [nucleotide binding]; other site 1121335003665 salt bridge; other site 1121335003666 sequence-specific DNA binding site [nucleotide binding]; other site 1121335003667 Cupin domain; Region: Cupin_2; pfam07883 1121335003668 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1121335003669 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1121335003670 Walker A/P-loop; other site 1121335003671 ATP binding site [chemical binding]; other site 1121335003672 Q-loop/lid; other site 1121335003673 ABC transporter signature motif; other site 1121335003674 Walker B; other site 1121335003675 D-loop; other site 1121335003676 H-loop/switch region; other site 1121335003677 TOBE domain; Region: TOBE_2; pfam08402 1121335003678 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1121335003679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003680 dimer interface [polypeptide binding]; other site 1121335003681 conserved gate region; other site 1121335003682 putative PBP binding loops; other site 1121335003683 ABC-ATPase subunit interface; other site 1121335003684 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1121335003685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003686 dimer interface [polypeptide binding]; other site 1121335003687 conserved gate region; other site 1121335003688 putative PBP binding loops; other site 1121335003689 ABC-ATPase subunit interface; other site 1121335003690 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1121335003691 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1121335003692 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1121335003693 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1121335003694 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1121335003695 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1121335003696 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1121335003697 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1121335003698 homodimer interface [polypeptide binding]; other site 1121335003699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335003700 catalytic residue [active] 1121335003701 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1121335003702 thymidylate kinase; Validated; Region: tmk; PRK00698 1121335003703 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1121335003704 TMP-binding site; other site 1121335003705 ATP-binding site [chemical binding]; other site 1121335003706 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1121335003707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003708 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1121335003709 Walker A motif; other site 1121335003710 ATP binding site [chemical binding]; other site 1121335003711 DNA polymerase III subunit delta'; Validated; Region: PRK07132 1121335003712 Walker B motif; other site 1121335003713 arginine finger; other site 1121335003714 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1121335003715 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335003716 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121335003717 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1121335003718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335003719 Fumarase C-terminus; Region: Fumerase_C; cl00795 1121335003720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335003721 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335003722 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335003723 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1121335003724 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335003725 dimer interface [polypeptide binding]; other site 1121335003726 PYR/PP interface [polypeptide binding]; other site 1121335003727 TPP binding site [chemical binding]; other site 1121335003728 substrate binding site [chemical binding]; other site 1121335003729 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335003730 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1121335003731 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1121335003732 TPP-binding site [chemical binding]; other site 1121335003733 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1121335003734 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1121335003735 QueT transporter; Region: QueT; pfam06177 1121335003736 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121335003737 ribonuclease R; Region: RNase_R; TIGR02063 1121335003738 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1121335003739 RNB domain; Region: RNB; pfam00773 1121335003740 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1121335003741 RNA binding site [nucleotide binding]; other site 1121335003742 or inactivated derivative; COG:3328 Transposase and inactivated derivatives; transposase 1121335003743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335003744 MULE transposase domain; Region: MULE; pfam10551 1121335003745 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003746 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1121335003747 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1121335003748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335003749 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1121335003750 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1121335003751 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335003752 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121335003753 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121335003754 Type II/IV secretion system protein; Region: T2SE; pfam00437 1121335003755 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121335003756 Walker A motif; other site 1121335003757 ATP binding site [chemical binding]; other site 1121335003758 Walker B motif; other site 1121335003759 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1121335003760 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1121335003761 Walker A motif; other site 1121335003762 ATP binding site [chemical binding]; other site 1121335003763 Walker B motif; other site 1121335003764 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1121335003765 Cell division protein FtsA; Region: FtsA; cl17206 1121335003766 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1121335003767 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1121335003768 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121335003769 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121335003770 Uncharacterized protein family (UPF0179); Region: UPF0179; cl00805 1121335003771 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1121335003772 S-layer homology domain; Region: SLH; pfam00395 1121335003773 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335003774 metal ion-dependent adhesion site (MIDAS); other site 1121335003775 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1121335003776 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1121335003777 homodimer interface [polypeptide binding]; other site 1121335003778 substrate-cofactor binding pocket; other site 1121335003779 catalytic residue [active] 1121335003780 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1121335003781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335003782 active site 1121335003783 motif I; other site 1121335003784 motif II; other site 1121335003785 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1121335003786 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121335003787 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121335003788 shikimate binding site; other site 1121335003789 NAD(P) binding site [chemical binding]; other site 1121335003790 Late competence development protein ComFB; Region: ComFB; pfam10719 1121335003791 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335003792 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335003793 Walker A/P-loop; other site 1121335003794 ATP binding site [chemical binding]; other site 1121335003795 Q-loop/lid; other site 1121335003796 ABC transporter signature motif; other site 1121335003797 Walker B; other site 1121335003798 D-loop; other site 1121335003799 H-loop/switch region; other site 1121335003800 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335003801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003802 dimer interface [polypeptide binding]; other site 1121335003803 conserved gate region; other site 1121335003804 putative PBP binding loops; other site 1121335003805 ABC-ATPase subunit interface; other site 1121335003806 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335003807 NMT1-like family; Region: NMT1_2; pfam13379 1121335003808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1121335003809 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1121335003810 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1121335003811 Glucose inhibited division protein A; Region: GIDA; pfam01134 1121335003812 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1121335003813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003814 Walker A motif; other site 1121335003815 ATP binding site [chemical binding]; other site 1121335003816 Walker B motif; other site 1121335003817 arginine finger; other site 1121335003818 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1121335003819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003820 Walker A motif; other site 1121335003821 ATP binding site [chemical binding]; other site 1121335003822 Walker B motif; other site 1121335003823 arginine finger; other site 1121335003824 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1121335003825 propionate/acetate kinase; Provisional; Region: PRK12379 1121335003826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121335003827 nucleotide binding site [chemical binding]; other site 1121335003828 butyrate kinase; Provisional; Region: PRK03011 1121335003829 aspartate kinase; Reviewed; Region: PRK09034 1121335003830 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1121335003831 nucleotide binding site [chemical binding]; other site 1121335003832 substrate binding site [chemical binding]; other site 1121335003833 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121335003834 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1121335003835 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335003836 MULE transposase domain; Region: MULE; pfam10551 1121335003837 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1121335003838 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1121335003839 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1121335003840 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1121335003841 active site 1121335003842 dimer interface [polypeptide binding]; other site 1121335003843 metal binding site [ion binding]; metal-binding site 1121335003844 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1121335003845 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1121335003846 hinge; other site 1121335003847 active site 1121335003848 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1121335003849 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1121335003850 Tetramer interface [polypeptide binding]; other site 1121335003851 active site 1121335003852 FMN-binding site [chemical binding]; other site 1121335003853 hypothetical protein; Provisional; Region: PRK07248 1121335003854 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1121335003855 Prephenate dehydratase; Region: PDT; pfam00800 1121335003856 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1121335003857 putative L-Phe binding site [chemical binding]; other site 1121335003858 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1121335003859 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121335003860 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121335003861 shikimate binding site; other site 1121335003862 NAD(P) binding site [chemical binding]; other site 1121335003863 shikimate kinase; Reviewed; Region: aroK; PRK00131 1121335003864 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121335003865 ADP binding site [chemical binding]; other site 1121335003866 magnesium binding site [ion binding]; other site 1121335003867 putative shikimate binding site; other site 1121335003868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1121335003869 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121335003870 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335003871 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335003872 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335003873 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1121335003874 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1121335003875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335003876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335003877 homodimer interface [polypeptide binding]; other site 1121335003878 catalytic residue [active] 1121335003879 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1121335003880 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1121335003881 tetramer interface [polypeptide binding]; other site 1121335003882 active site 1121335003883 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1121335003884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335003885 DNA-binding site [nucleotide binding]; DNA binding site 1121335003886 UTRA domain; Region: UTRA; pfam07702 1121335003887 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335003888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121335003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335003890 dimer interface [polypeptide binding]; other site 1121335003891 ABC-ATPase subunit interface; other site 1121335003892 putative PBP binding loops; other site 1121335003893 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335003894 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335003895 Walker A/P-loop; other site 1121335003896 ATP binding site [chemical binding]; other site 1121335003897 Q-loop/lid; other site 1121335003898 ABC transporter signature motif; other site 1121335003899 Walker B; other site 1121335003900 D-loop; other site 1121335003901 H-loop/switch region; other site 1121335003902 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1121335003903 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1121335003904 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1121335003905 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121335003906 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1121335003907 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1121335003908 Preprotein translocase subunit; Region: YajC; pfam02699 1121335003909 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1121335003910 RimM N-terminal domain; Region: RimM; pfam01782 1121335003911 PRC-barrel domain; Region: PRC; pfam05239 1121335003912 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1121335003913 recombination factor protein RarA; Reviewed; Region: PRK13342 1121335003914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335003915 Walker A motif; other site 1121335003916 ATP binding site [chemical binding]; other site 1121335003917 Walker B motif; other site 1121335003918 arginine finger; other site 1121335003919 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1121335003920 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1121335003921 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1121335003922 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 1121335003923 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1121335003924 oligomer interface [polypeptide binding]; other site 1121335003925 putative active site [active] 1121335003926 metal binding site [ion binding]; metal-binding site 1121335003927 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335003928 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1121335003929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003930 binding surface 1121335003931 TPR motif; other site 1121335003932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003933 binding surface 1121335003934 TPR motif; other site 1121335003935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003936 binding surface 1121335003937 TPR motif; other site 1121335003938 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1121335003939 Active site serine [active] 1121335003940 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1121335003941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335003942 active site 1121335003943 DNA binding site [nucleotide binding] 1121335003944 Int/Topo IB signature motif; other site 1121335003945 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1121335003946 active site 1121335003947 catalytic site [active] 1121335003948 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1121335003949 regulatory protein CsrD; Provisional; Region: PRK11059 1121335003950 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121335003951 Catalytic site [active] 1121335003952 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1121335003953 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121335003954 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1121335003955 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1121335003956 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1121335003957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335003958 binding surface 1121335003959 TPR motif; other site 1121335003960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335003961 active site 1121335003962 I-site; other site 1121335003963 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1121335003964 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1121335003965 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1121335003966 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 1121335003967 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 1121335003968 dimerization interface [polypeptide binding]; other site 1121335003969 putative ATP binding site [chemical binding]; other site 1121335003970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 1121335003971 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 1121335003972 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1121335003973 VanW like protein; Region: VanW; pfam04294 1121335003974 G5 domain; Region: G5; pfam07501 1121335003975 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1121335003976 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1121335003977 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1121335003978 Ligand Binding Site [chemical binding]; other site 1121335003979 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121335003980 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121335003981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335003982 catalytic residue [active] 1121335003983 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1121335003984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335003985 active site 1121335003986 metal binding site [ion binding]; metal-binding site 1121335003987 homotetramer interface [polypeptide binding]; other site 1121335003988 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1121335003989 active site 1121335003990 dimerization interface [polypeptide binding]; other site 1121335003991 ribonuclease PH; Reviewed; Region: rph; PRK00173 1121335003992 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1121335003993 hexamer interface [polypeptide binding]; other site 1121335003994 active site 1121335003995 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335003996 AMIN domain; Region: AMIN; pfam11741 1121335003997 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335003998 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335003999 active site 1121335004000 metal binding site [ion binding]; metal-binding site 1121335004001 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 1121335004002 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121335004003 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121335004004 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121335004005 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1121335004006 Protein of unknown function DUF116; Region: DUF116; pfam01976 1121335004007 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1121335004008 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1121335004009 putative active site [active] 1121335004010 substrate binding site [chemical binding]; other site 1121335004011 putative cosubstrate binding site; other site 1121335004012 catalytic site [active] 1121335004013 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1121335004014 substrate binding site [chemical binding]; other site 1121335004015 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121335004016 active site 1121335004017 catalytic residues [active] 1121335004018 metal binding site [ion binding]; metal-binding site 1121335004019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335004020 primosomal protein N' Region: priA; TIGR00595 1121335004021 ATP binding site [chemical binding]; other site 1121335004022 putative Mg++ binding site [ion binding]; other site 1121335004023 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 1121335004024 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 1121335004025 Zn binding sites [ion binding]; other site 1121335004026 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1121335004027 single-stranded DNA-binding protein; Provisional; Region: PRK05813 1121335004028 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121335004029 dimer interface [polypeptide binding]; other site 1121335004030 ssDNA binding site [nucleotide binding]; other site 1121335004031 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121335004032 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1121335004033 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1121335004034 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1121335004035 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1121335004036 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121335004037 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121335004038 active site 1121335004039 ATP binding site [chemical binding]; other site 1121335004040 substrate binding site [chemical binding]; other site 1121335004041 activation loop (A-loop); other site 1121335004042 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1121335004043 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1121335004044 hinge region; other site 1121335004045 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1121335004046 putative nucleotide binding site [chemical binding]; other site 1121335004047 uridine monophosphate binding site [chemical binding]; other site 1121335004048 homohexameric interface [polypeptide binding]; other site 1121335004049 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1121335004050 UBA/TS-N domain; Region: UBA; pfam00627 1121335004051 Elongation factor TS; Region: EF_TS; pfam00889 1121335004052 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1121335004053 rRNA interaction site [nucleotide binding]; other site 1121335004054 S8 interaction site; other site 1121335004055 putative laminin-1 binding site; other site 1121335004056 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1121335004057 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1121335004058 ATP binding site [chemical binding]; other site 1121335004059 Walker A motif; other site 1121335004060 hexamer interface [polypeptide binding]; other site 1121335004061 Walker B motif; other site 1121335004062 AAA domain; Region: AAA_31; pfam13614 1121335004063 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1121335004064 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1121335004065 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1121335004066 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121335004067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004068 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335004069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004070 DNA binding residues [nucleotide binding] 1121335004071 DNA primase, catalytic core; Region: dnaG; TIGR01391 1121335004072 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1121335004073 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1121335004074 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1121335004075 active site 1121335004076 metal binding site [ion binding]; metal-binding site 1121335004077 interdomain interaction site; other site 1121335004078 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1121335004079 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1121335004080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004081 Zn2+ binding site [ion binding]; other site 1121335004082 Mg2+ binding site [ion binding]; other site 1121335004083 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1121335004084 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1121335004085 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1121335004086 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1121335004087 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1121335004088 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1121335004089 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121335004090 putative valine binding site [chemical binding]; other site 1121335004091 dimer interface [polypeptide binding]; other site 1121335004092 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1121335004093 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1121335004094 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 1121335004095 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121335004096 PYR/PP interface [polypeptide binding]; other site 1121335004097 dimer interface [polypeptide binding]; other site 1121335004098 TPP binding site [chemical binding]; other site 1121335004099 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121335004100 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121335004101 TPP-binding site [chemical binding]; other site 1121335004102 dimer interface [polypeptide binding]; other site 1121335004103 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1121335004104 tartrate dehydrogenase; Region: TTC; TIGR02089 1121335004105 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1121335004106 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1121335004107 substrate binding site [chemical binding]; other site 1121335004108 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1121335004109 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1121335004110 substrate binding site [chemical binding]; other site 1121335004111 ligand binding site [chemical binding]; other site 1121335004112 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1121335004113 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1121335004114 putative active site [active] 1121335004115 putative metal binding site [ion binding]; other site 1121335004116 DNA topoisomerase I; Validated; Region: PRK05582 1121335004117 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1121335004118 active site 1121335004119 interdomain interaction site; other site 1121335004120 putative metal-binding site [ion binding]; other site 1121335004121 nucleotide binding site [chemical binding]; other site 1121335004122 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1121335004123 domain I; other site 1121335004124 DNA binding groove [nucleotide binding] 1121335004125 phosphate binding site [ion binding]; other site 1121335004126 domain II; other site 1121335004127 domain III; other site 1121335004128 nucleotide binding site [chemical binding]; other site 1121335004129 catalytic site [active] 1121335004130 domain IV; other site 1121335004131 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121335004132 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121335004133 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1121335004134 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121335004135 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335004136 beta-D-glucuronidase; Provisional; Region: PRK10150 1121335004137 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335004138 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335004139 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1121335004140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335004141 FeS/SAM binding site; other site 1121335004142 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121335004143 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1121335004144 putative active site [active] 1121335004145 dimerization interface [polypeptide binding]; other site 1121335004146 putative tRNAtyr binding site [nucleotide binding]; other site 1121335004147 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121335004148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004149 Zn2+ binding site [ion binding]; other site 1121335004150 Mg2+ binding site [ion binding]; other site 1121335004151 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121335004152 synthetase active site [active] 1121335004153 NTP binding site [chemical binding]; other site 1121335004154 metal binding site [ion binding]; metal-binding site 1121335004155 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1121335004156 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1121335004157 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1121335004158 DHH family; Region: DHH; pfam01368 1121335004159 DHHA1 domain; Region: DHHA1; pfam02272 1121335004160 Protein of unknown function (DUF3228); Region: DUF3228; pfam11539 1121335004161 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1121335004162 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1121335004163 nucleotide binding site/active site [active] 1121335004164 HIT family signature motif; other site 1121335004165 catalytic residue [active] 1121335004166 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1121335004167 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1121335004168 motif 1; other site 1121335004169 active site 1121335004170 motif 2; other site 1121335004171 motif 3; other site 1121335004172 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1121335004173 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121335004174 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1121335004175 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121335004176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335004177 active site 1121335004178 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121335004179 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121335004180 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1121335004181 PRC-barrel domain; Region: PRC; pfam05239 1121335004182 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1121335004183 Putative amidase domain; Region: Amidase_6; pfam12671 1121335004184 sporulation sigma factor SigF; Validated; Region: PRK05572 1121335004185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004186 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335004187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004188 DNA binding residues [nucleotide binding] 1121335004189 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1121335004190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004191 ATP binding site [chemical binding]; other site 1121335004192 Mg2+ binding site [ion binding]; other site 1121335004193 G-X-G motif; other site 1121335004194 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121335004195 anti sigma factor interaction site; other site 1121335004196 regulatory phosphorylation site [posttranslational modification]; other site 1121335004197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1121335004198 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1121335004199 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1121335004200 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 1121335004201 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1121335004202 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1121335004203 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1121335004204 phosphate binding site [ion binding]; other site 1121335004205 putative substrate binding pocket [chemical binding]; other site 1121335004206 dimer interface [polypeptide binding]; other site 1121335004207 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1121335004208 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1121335004209 FAD binding domain; Region: FAD_binding_4; pfam01565 1121335004210 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1121335004211 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1121335004212 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1121335004213 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1121335004214 Hpr binding site; other site 1121335004215 active site 1121335004216 homohexamer subunit interaction site [polypeptide binding]; other site 1121335004217 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1121335004218 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1121335004219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335004220 catalytic residue [active] 1121335004221 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 1121335004222 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 1121335004223 Predicted membrane protein [Function unknown]; Region: COG2246 1121335004224 GtrA-like protein; Region: GtrA; pfam04138 1121335004225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335004226 hypothetical protein; Provisional; Region: PRK07233 1121335004227 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121335004228 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121335004229 Ligand binding site; other site 1121335004230 Putative Catalytic site; other site 1121335004231 DXD motif; other site 1121335004232 Cation efflux family; Region: Cation_efflux; cl00316 1121335004233 putative oxidoreductase; Provisional; Region: PRK11445 1121335004234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335004235 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1121335004236 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335004237 motif 1; other site 1121335004238 dimer interface [polypeptide binding]; other site 1121335004239 active site 1121335004240 motif 2; other site 1121335004241 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1121335004242 putative deacylase active site [active] 1121335004243 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335004244 active site 1121335004245 motif 3; other site 1121335004246 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1121335004247 anticodon binding site; other site 1121335004248 HD domain; Region: HD_3; pfam13023 1121335004249 heat shock protein 90; Provisional; Region: PRK05218 1121335004250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004251 ATP binding site [chemical binding]; other site 1121335004252 Mg2+ binding site [ion binding]; other site 1121335004253 G-X-G motif; other site 1121335004254 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1121335004255 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121335004256 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121335004257 RIP metalloprotease RseP; Region: TIGR00054 1121335004258 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121335004259 active site 1121335004260 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121335004261 protein binding site [polypeptide binding]; other site 1121335004262 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121335004263 protein binding site [polypeptide binding]; other site 1121335004264 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121335004265 putative substrate binding region [chemical binding]; other site 1121335004266 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1121335004267 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1121335004268 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1121335004269 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1121335004270 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121335004271 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121335004272 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1121335004273 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1121335004274 catalytic residue [active] 1121335004275 putative FPP diphosphate binding site; other site 1121335004276 putative FPP binding hydrophobic cleft; other site 1121335004277 dimer interface [polypeptide binding]; other site 1121335004278 putative IPP diphosphate binding site; other site 1121335004279 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1121335004280 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1121335004281 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1121335004282 phosphopeptide binding site; other site 1121335004283 TadE-like protein; Region: TadE; pfam07811 1121335004284 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1121335004285 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1121335004286 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121335004287 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1121335004288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335004289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335004290 dimerization interface [polypeptide binding]; other site 1121335004291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335004292 dimer interface [polypeptide binding]; other site 1121335004293 phosphorylation site [posttranslational modification] 1121335004294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004295 ATP binding site [chemical binding]; other site 1121335004296 Mg2+ binding site [ion binding]; other site 1121335004297 G-X-G motif; other site 1121335004298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335004299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335004300 active site 1121335004301 phosphorylation site [posttranslational modification] 1121335004302 intermolecular recognition site; other site 1121335004303 dimerization interface [polypeptide binding]; other site 1121335004304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335004305 DNA binding site [nucleotide binding] 1121335004306 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 1121335004307 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1121335004308 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121335004309 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121335004310 putative acyl-acceptor binding pocket; other site 1121335004311 GMP synthase; Reviewed; Region: guaA; PRK00074 1121335004312 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1121335004313 AMP/PPi binding site [chemical binding]; other site 1121335004314 candidate oxyanion hole; other site 1121335004315 catalytic triad [active] 1121335004316 potential glutamine specificity residues [chemical binding]; other site 1121335004317 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1121335004318 ATP Binding subdomain [chemical binding]; other site 1121335004319 Ligand Binding sites [chemical binding]; other site 1121335004320 Dimerization subdomain; other site 1121335004321 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1121335004322 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1121335004323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335004324 S-adenosylmethionine binding site [chemical binding]; other site 1121335004325 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 1121335004326 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1121335004327 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121335004328 dimer interface [polypeptide binding]; other site 1121335004329 PYR/PP interface [polypeptide binding]; other site 1121335004330 TPP binding site [chemical binding]; other site 1121335004331 substrate binding site [chemical binding]; other site 1121335004332 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121335004333 Domain of unknown function; Region: EKR; pfam10371 1121335004334 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1121335004335 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335004336 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1121335004337 TPP-binding site [chemical binding]; other site 1121335004338 dimer interface [polypeptide binding]; other site 1121335004339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335004340 MULE transposase domain; Region: MULE; pfam10551 1121335004341 Coat F domain; Region: Coat_F; pfam07875 1121335004342 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1121335004343 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121335004344 homodimer interface [polypeptide binding]; other site 1121335004345 substrate-cofactor binding pocket; other site 1121335004346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335004347 catalytic residue [active] 1121335004348 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1121335004349 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1121335004350 proposed active site lysine [active] 1121335004351 conserved cys residue [active] 1121335004352 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1121335004353 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1121335004354 generic binding surface II; other site 1121335004355 generic binding surface I; other site 1121335004356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004357 Zn2+ binding site [ion binding]; other site 1121335004358 Mg2+ binding site [ion binding]; other site 1121335004359 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121335004360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335004361 Zn2+ binding site [ion binding]; other site 1121335004362 Mg2+ binding site [ion binding]; other site 1121335004363 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1121335004364 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1121335004365 active site 1121335004366 substrate binding site [chemical binding]; other site 1121335004367 metal binding site [ion binding]; metal-binding site 1121335004368 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1121335004369 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335004370 putative active site [active] 1121335004371 metal binding site [ion binding]; metal-binding site 1121335004372 homodimer binding site [polypeptide binding]; other site 1121335004373 phosphodiesterase; Provisional; Region: PRK12704 1121335004374 uncharacterized domain HDIG; Region: HDIG; TIGR00277 1121335004375 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1121335004376 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1121335004377 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1121335004378 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1121335004379 homodimer interface [polypeptide binding]; other site 1121335004380 NADP binding site [chemical binding]; other site 1121335004381 substrate binding site [chemical binding]; other site 1121335004382 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 1121335004383 TPR repeat; Region: TPR_11; pfam13414 1121335004384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004385 binding surface 1121335004386 TPR motif; other site 1121335004387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335004388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004389 binding surface 1121335004390 TPR repeat; Region: TPR_11; pfam13414 1121335004391 TPR motif; other site 1121335004392 TPR repeat; Region: TPR_11; pfam13414 1121335004393 TPR repeat; Region: TPR_11; pfam13414 1121335004394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004395 binding surface 1121335004396 TPR motif; other site 1121335004397 TPR repeat; Region: TPR_11; pfam13414 1121335004398 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1121335004399 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1121335004400 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121335004401 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1121335004402 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1121335004403 dimerization interface [polypeptide binding]; other site 1121335004404 putative active cleft [active] 1121335004405 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1121335004406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335004407 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1121335004408 active site 1121335004409 DNA binding site [nucleotide binding] 1121335004410 Int/Topo IB signature motif; other site 1121335004411 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1121335004412 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1121335004413 dimer interface [polypeptide binding]; other site 1121335004414 ADP-ribose binding site [chemical binding]; other site 1121335004415 active site 1121335004416 nudix motif; other site 1121335004417 metal binding site [ion binding]; metal-binding site 1121335004418 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1121335004419 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121335004420 active site 1121335004421 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1121335004422 pyrroline-5-carboxylate reductase; Region: PLN02688 1121335004423 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1121335004424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004425 Walker A motif; other site 1121335004426 ATP binding site [chemical binding]; other site 1121335004427 Walker B motif; other site 1121335004428 arginine finger; other site 1121335004429 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1121335004430 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1121335004431 RuvA N terminal domain; Region: RuvA_N; pfam01330 1121335004432 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1121335004433 active site 1121335004434 putative DNA-binding cleft [nucleotide binding]; other site 1121335004435 dimer interface [polypeptide binding]; other site 1121335004436 argininosuccinate synthase; Provisional; Region: PRK13820 1121335004437 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1121335004438 ANP binding site [chemical binding]; other site 1121335004439 Substrate Binding Site II [chemical binding]; other site 1121335004440 Substrate Binding Site I [chemical binding]; other site 1121335004441 argininosuccinate lyase; Provisional; Region: PRK00855 1121335004442 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1121335004443 active sites [active] 1121335004444 tetramer interface [polypeptide binding]; other site 1121335004445 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121335004446 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1121335004447 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1121335004448 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1121335004449 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121335004450 active site 1121335004451 6-phosphofructokinase; Provisional; Region: PRK03202 1121335004452 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1121335004453 active site 1121335004454 ADP/pyrophosphate binding site [chemical binding]; other site 1121335004455 dimerization interface [polypeptide binding]; other site 1121335004456 allosteric effector site; other site 1121335004457 fructose-1,6-bisphosphate binding site; other site 1121335004458 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 1121335004459 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1121335004460 active site 1121335004461 PHP Thumb interface [polypeptide binding]; other site 1121335004462 metal binding site [ion binding]; metal-binding site 1121335004463 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1121335004464 generic binding surface II; other site 1121335004465 generic binding surface I; other site 1121335004466 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121335004467 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1121335004468 putative active site [active] 1121335004469 putative metal binding site [ion binding]; other site 1121335004470 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1121335004471 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1121335004472 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1121335004473 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121335004474 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121335004475 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1121335004476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335004477 S-adenosylmethionine binding site [chemical binding]; other site 1121335004478 YceG-like family; Region: YceG; pfam02618 1121335004479 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1121335004480 dimerization interface [polypeptide binding]; other site 1121335004481 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1121335004482 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1121335004483 G1 box; other site 1121335004484 putative GEF interaction site [polypeptide binding]; other site 1121335004485 GTP/Mg2+ binding site [chemical binding]; other site 1121335004486 Switch I region; other site 1121335004487 G2 box; other site 1121335004488 G3 box; other site 1121335004489 Switch II region; other site 1121335004490 G4 box; other site 1121335004491 G5 box; other site 1121335004492 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1121335004493 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1121335004494 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121335004495 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335004496 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1121335004497 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1121335004498 Protein of unknown function DUF58; Region: DUF58; pfam01882 1121335004499 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335004500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004501 Walker A motif; other site 1121335004502 ATP binding site [chemical binding]; other site 1121335004503 Walker B motif; other site 1121335004504 arginine finger; other site 1121335004505 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 1121335004506 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335004507 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335004508 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1121335004509 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1121335004510 putative ATP binding site [chemical binding]; other site 1121335004511 putative substrate interface [chemical binding]; other site 1121335004512 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335004513 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1121335004514 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335004515 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1121335004516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335004517 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1121335004518 putative active site [active] 1121335004519 Zn binding site [ion binding]; other site 1121335004520 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121335004521 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121335004522 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121335004523 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 1121335004524 LytB protein; Region: LYTB; cl00507 1121335004525 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1121335004526 RNA binding site [nucleotide binding]; other site 1121335004527 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1121335004528 RNA binding site [nucleotide binding]; other site 1121335004529 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1121335004530 RNA binding site [nucleotide binding]; other site 1121335004531 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121335004532 RNA binding site [nucleotide binding]; other site 1121335004533 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121335004534 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121335004535 putative acyl-acceptor binding pocket; other site 1121335004536 cytidylate kinase; Provisional; Region: cmk; PRK00023 1121335004537 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1121335004538 CMP-binding site; other site 1121335004539 The sites determining sugar specificity; other site 1121335004540 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1121335004541 hexamer interface [polypeptide binding]; other site 1121335004542 RNA binding site [nucleotide binding]; other site 1121335004543 Histidine-zinc binding site [chemical binding]; other site 1121335004544 HI0933-like protein; Region: HI0933_like; pfam03486 1121335004545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335004546 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1121335004547 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1121335004548 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1121335004549 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1121335004550 putative active site [active] 1121335004551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335004552 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1121335004553 active site 1121335004554 motif I; other site 1121335004555 motif II; other site 1121335004556 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335004557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335004558 S-adenosylmethionine binding site [chemical binding]; other site 1121335004559 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1121335004560 Protein of unknown function DUF45; Region: DUF45; cl00636 1121335004561 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1121335004562 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1121335004563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335004564 ATP binding site [chemical binding]; other site 1121335004565 putative Mg++ binding site [ion binding]; other site 1121335004566 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121335004567 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121335004568 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1121335004569 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1121335004570 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121335004571 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335004572 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1121335004573 NAD synthetase; Reviewed; Region: nadE; PRK02628 1121335004574 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1121335004575 multimer interface [polypeptide binding]; other site 1121335004576 active site 1121335004577 catalytic triad [active] 1121335004578 protein interface 1 [polypeptide binding]; other site 1121335004579 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1121335004580 homodimer interface [polypeptide binding]; other site 1121335004581 NAD binding pocket [chemical binding]; other site 1121335004582 ATP binding pocket [chemical binding]; other site 1121335004583 Mg binding site [ion binding]; other site 1121335004584 active-site loop [active] 1121335004585 hypothetical protein; Provisional; Region: PRK06851 1121335004586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004587 Walker A motif; other site 1121335004588 ATP binding site [chemical binding]; other site 1121335004589 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004590 active site 1121335004591 NAD binding site [chemical binding]; other site 1121335004592 metal binding site [ion binding]; metal-binding site 1121335004593 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004594 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1121335004595 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335004596 metal ion-dependent adhesion site (MIDAS); other site 1121335004597 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1121335004598 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121335004599 metal ion-dependent adhesion site (MIDAS); other site 1121335004600 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1121335004601 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1121335004602 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335004603 metal ion-dependent adhesion site (MIDAS); other site 1121335004604 Protein of unknown function DUF58; Region: DUF58; pfam01882 1121335004605 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335004606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004607 Walker A motif; other site 1121335004608 ATP binding site [chemical binding]; other site 1121335004609 Walker B motif; other site 1121335004610 arginine finger; other site 1121335004611 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121335004612 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335004613 Walker A/P-loop; other site 1121335004614 ATP binding site [chemical binding]; other site 1121335004615 Q-loop/lid; other site 1121335004616 ABC transporter signature motif; other site 1121335004617 Walker B; other site 1121335004618 D-loop; other site 1121335004619 H-loop/switch region; other site 1121335004620 DNA protecting protein DprA; Region: dprA; TIGR00732 1121335004621 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1121335004622 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1121335004623 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1121335004624 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121335004625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335004626 Walker A motif; other site 1121335004627 ATP binding site [chemical binding]; other site 1121335004628 Walker B motif; other site 1121335004629 arginine finger; other site 1121335004630 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1121335004631 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1121335004632 active site 1121335004633 catalytic triad [active] 1121335004634 oxyanion hole [active] 1121335004635 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1121335004636 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1121335004637 Spore germination protein; Region: Spore_permease; cl17796 1121335004638 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1121335004639 (R)-citramalate synthase; Provisional; Region: PRK09389 1121335004640 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1121335004641 active site 1121335004642 catalytic residues [active] 1121335004643 metal binding site [ion binding]; metal-binding site 1121335004644 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1121335004645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121335004646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335004647 active site 1121335004648 phosphorylation site [posttranslational modification] 1121335004649 intermolecular recognition site; other site 1121335004650 dimerization interface [polypeptide binding]; other site 1121335004651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121335004652 DNA binding residues [nucleotide binding] 1121335004653 dimerization interface [polypeptide binding]; other site 1121335004654 Sensor protein DegS; Region: DegS; pfam05384 1121335004655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121335004656 Histidine kinase; Region: HisKA_3; pfam07730 1121335004657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004658 ATP binding site [chemical binding]; other site 1121335004659 Mg2+ binding site [ion binding]; other site 1121335004660 G-X-G motif; other site 1121335004661 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1121335004662 ATP cone domain; Region: ATP-cone; pfam03477 1121335004663 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1121335004664 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1121335004665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004666 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335004667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004668 DNA binding residues [nucleotide binding] 1121335004669 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1121335004670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335004671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335004672 DNA binding residues [nucleotide binding] 1121335004673 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1121335004674 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1121335004675 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121335004676 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1121335004677 CAAX protease self-immunity; Region: Abi; pfam02517 1121335004678 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1121335004679 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1121335004680 putative catalytic cysteine [active] 1121335004681 Hemerythrin; Region: Hemerythrin; cd12107 1121335004682 Fe binding site [ion binding]; other site 1121335004683 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1121335004684 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1121335004685 G1 box; other site 1121335004686 putative GEF interaction site [polypeptide binding]; other site 1121335004687 GTP/Mg2+ binding site [chemical binding]; other site 1121335004688 Switch I region; other site 1121335004689 G2 box; other site 1121335004690 G3 box; other site 1121335004691 Switch II region; other site 1121335004692 G4 box; other site 1121335004693 G5 box; other site 1121335004694 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1121335004695 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1121335004696 ACT domain-containing protein [General function prediction only]; Region: COG4747 1121335004697 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 1121335004698 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 1121335004699 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1121335004700 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1121335004701 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1121335004702 NADP-binding site; other site 1121335004703 homotetramer interface [polypeptide binding]; other site 1121335004704 substrate binding site [chemical binding]; other site 1121335004705 homodimer interface [polypeptide binding]; other site 1121335004706 active site 1121335004707 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1121335004708 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1121335004709 NADP binding site [chemical binding]; other site 1121335004710 active site 1121335004711 putative substrate binding site [chemical binding]; other site 1121335004712 DivIVA protein; Region: DivIVA; pfam05103 1121335004713 Phosphotransferase enzyme family; Region: APH; pfam01636 1121335004714 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121335004715 active site 1121335004716 ATP binding site [chemical binding]; other site 1121335004717 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004718 GDP-Fucose binding site [chemical binding]; other site 1121335004719 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004720 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 1121335004721 GDP-Fucose binding site [chemical binding]; other site 1121335004722 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004723 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 1121335004724 GDP-Fucose binding site [chemical binding]; other site 1121335004725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335004726 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121335004727 NAD(P) binding site [chemical binding]; other site 1121335004728 active site 1121335004729 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1121335004730 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1121335004731 alpha subunit interface [polypeptide binding]; other site 1121335004732 TPP binding site [chemical binding]; other site 1121335004733 heterodimer interface [polypeptide binding]; other site 1121335004734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335004735 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1121335004736 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1121335004737 tetramer interface [polypeptide binding]; other site 1121335004738 TPP-binding site [chemical binding]; other site 1121335004739 heterodimer interface [polypeptide binding]; other site 1121335004740 phosphorylation loop region [posttranslational modification] 1121335004741 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1121335004742 GDP-Fucose binding site [chemical binding]; other site 1121335004743 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1121335004744 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1121335004745 Substrate binding site; other site 1121335004746 Cupin domain; Region: Cupin_2; cl17218 1121335004747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121335004748 LexA repressor; Validated; Region: PRK00215 1121335004749 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1121335004750 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121335004751 Catalytic site [active] 1121335004752 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1121335004753 DivIVA protein; Region: DivIVA; pfam05103 1121335004754 YGGT family; Region: YGGT; pfam02325 1121335004755 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1121335004756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1121335004757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335004758 catalytic residue [active] 1121335004759 HlyD family secretion protein; Region: HlyD_2; pfam12700 1121335004760 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1121335004761 Aluminium resistance protein; Region: Alum_res; pfam06838 1121335004762 TPR repeat; Region: TPR_11; pfam13414 1121335004763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004764 binding surface 1121335004765 TPR motif; other site 1121335004766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335004767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335004768 binding surface 1121335004769 TPR motif; other site 1121335004770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335004771 Quinolinate synthetase A protein; Region: NadA; pfam02445 1121335004772 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335004773 active site 1121335004774 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121335004775 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1121335004776 putative ligand binding site [chemical binding]; other site 1121335004777 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1121335004778 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335004779 Walker A/P-loop; other site 1121335004780 ATP binding site [chemical binding]; other site 1121335004781 Q-loop/lid; other site 1121335004782 ABC transporter signature motif; other site 1121335004783 Walker B; other site 1121335004784 D-loop; other site 1121335004785 H-loop/switch region; other site 1121335004786 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335004787 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335004788 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121335004789 TM-ABC transporter signature motif; other site 1121335004790 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335004791 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121335004792 TM-ABC transporter signature motif; other site 1121335004793 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121335004794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335004795 RNA binding surface [nucleotide binding]; other site 1121335004796 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121335004797 active site 1121335004798 lipoprotein signal peptidase; Provisional; Region: PRK14787 1121335004799 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1121335004800 Stage II sporulation protein; Region: SpoIID; pfam08486 1121335004801 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1121335004802 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1121335004803 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335004804 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1121335004805 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1121335004806 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335004807 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335004808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004809 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335004810 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335004811 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1121335004812 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1121335004813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335004814 FeS/SAM binding site; other site 1121335004815 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1121335004816 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1121335004817 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121335004818 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335004819 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1121335004820 nucleotide binding site [chemical binding]; other site 1121335004821 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1121335004822 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1121335004823 active site 1121335004824 DNA binding site [nucleotide binding] 1121335004825 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1121335004826 DNA binding site [nucleotide binding] 1121335004827 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1121335004828 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1121335004829 putative DNA binding site [nucleotide binding]; other site 1121335004830 putative homodimer interface [polypeptide binding]; other site 1121335004831 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1121335004832 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1121335004833 active site 1121335004834 metal binding site [ion binding]; metal-binding site 1121335004835 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1121335004836 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335004837 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 1121335004838 S-layer homology domain; Region: SLH; pfam00395 1121335004839 S-layer homology domain; Region: SLH; pfam00395 1121335004840 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1121335004841 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1121335004842 intersubunit interface [polypeptide binding]; other site 1121335004843 active site 1121335004844 Zn2+ binding site [ion binding]; other site 1121335004845 ribulokinase; Provisional; Region: PRK04123 1121335004846 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1121335004847 N- and C-terminal domain interface [polypeptide binding]; other site 1121335004848 active site 1121335004849 MgATP binding site [chemical binding]; other site 1121335004850 catalytic site [active] 1121335004851 metal binding site [ion binding]; metal-binding site 1121335004852 carbohydrate binding site [chemical binding]; other site 1121335004853 homodimer interface [polypeptide binding]; other site 1121335004854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121335004855 DNA-binding site [nucleotide binding]; DNA binding site 1121335004856 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1121335004857 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1121335004858 putative ligand binding site [chemical binding]; other site 1121335004859 putative dimerization interface [polypeptide binding]; other site 1121335004860 L-arabinose isomerase; Provisional; Region: PRK02929 1121335004861 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1121335004862 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121335004863 trimer interface [polypeptide binding]; other site 1121335004864 putative substrate binding site [chemical binding]; other site 1121335004865 putative metal binding site [ion binding]; other site 1121335004866 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1121335004867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335004868 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121335004869 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1121335004870 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1121335004871 active site 1121335004872 NTP binding site [chemical binding]; other site 1121335004873 metal binding triad [ion binding]; metal-binding site 1121335004874 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1121335004875 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1121335004876 PQQ-like domain; Region: PQQ_2; pfam13360 1121335004877 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1121335004878 metal binding site [ion binding]; metal-binding site 1121335004879 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335004880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335004881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004882 dimer interface [polypeptide binding]; other site 1121335004883 conserved gate region; other site 1121335004884 putative PBP binding loops; other site 1121335004885 ABC-ATPase subunit interface; other site 1121335004886 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335004887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004888 dimer interface [polypeptide binding]; other site 1121335004889 conserved gate region; other site 1121335004890 putative PBP binding loops; other site 1121335004891 ABC-ATPase subunit interface; other site 1121335004892 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335004893 Histidine kinase; Region: His_kinase; pfam06580 1121335004894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335004895 ATP binding site [chemical binding]; other site 1121335004896 Mg2+ binding site [ion binding]; other site 1121335004897 G-X-G motif; other site 1121335004898 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335004899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335004900 active site 1121335004901 phosphorylation site [posttranslational modification] 1121335004902 intermolecular recognition site; other site 1121335004903 dimerization interface [polypeptide binding]; other site 1121335004904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335004905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004906 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 1121335004907 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335004908 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335004909 dimer interface [polypeptide binding]; other site 1121335004910 putative CheW interface [polypeptide binding]; other site 1121335004911 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1121335004912 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121335004913 ligand binding site [chemical binding]; other site 1121335004914 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1121335004915 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121335004916 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121335004917 Transporter associated domain; Region: CorC_HlyC; pfam03471 1121335004918 HEAT repeats; Region: HEAT_2; pfam13646 1121335004919 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121335004920 MarR family; Region: MarR_2; pfam12802 1121335004921 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121335004922 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1121335004923 AAA domain; Region: AAA_17; pfam13207 1121335004924 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1121335004925 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1121335004926 active site 1121335004927 catalytic site [active] 1121335004928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335004929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335004930 putative substrate translocation pore; other site 1121335004931 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1121335004932 active site 1121335004933 metal binding site [ion binding]; metal-binding site 1121335004934 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004935 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1121335004936 Na binding site [ion binding]; other site 1121335004937 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1121335004938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335004939 RNA binding surface [nucleotide binding]; other site 1121335004940 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1121335004941 active site 1121335004942 metal binding site [ion binding]; metal-binding site 1121335004943 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121335004944 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335004945 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335004946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335004948 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1121335004949 Melibiase; Region: Melibiase; pfam02065 1121335004950 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335004951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004952 dimer interface [polypeptide binding]; other site 1121335004953 conserved gate region; other site 1121335004954 putative PBP binding loops; other site 1121335004955 ABC-ATPase subunit interface; other site 1121335004956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335004957 dimer interface [polypeptide binding]; other site 1121335004958 conserved gate region; other site 1121335004959 putative PBP binding loops; other site 1121335004960 ABC-ATPase subunit interface; other site 1121335004961 PBP superfamily domain; Region: PBP_like_2; cl17296 1121335004962 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335004963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335004964 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1121335004965 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 1121335004966 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 1121335004967 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1121335004968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335004969 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1121335004970 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 1121335004971 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1121335004972 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 1121335004973 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1121335004974 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 1121335004975 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 1121335004976 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1121335004977 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1121335004978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335004979 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121335004980 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1121335004981 active site residue [active] 1121335004982 Repair protein; Region: Repair_PSII; pfam04536 1121335004983 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1121335004984 MgtC family; Region: MgtC; pfam02308 1121335004985 LemA family; Region: LemA; cl00742 1121335004986 LemA family; Region: LemA; cl00742 1121335004987 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121335004988 catalytic triad [active] 1121335004989 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1121335004990 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1121335004991 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1121335004992 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1121335004993 acyl-activating enzyme (AAE) consensus motif; other site 1121335004994 AMP binding site [chemical binding]; other site 1121335004995 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1121335004996 aspartate racemase; Region: asp_race; TIGR00035 1121335004997 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121335004998 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121335004999 ribonuclease Z; Region: RNase_Z; TIGR02651 1121335005000 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1121335005001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335005002 flavoprotein, HI0933 family; Region: TIGR00275 1121335005003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335005004 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121335005005 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1121335005006 acyl-activating enzyme (AAE) consensus motif; other site 1121335005007 AMP binding site [chemical binding]; other site 1121335005008 active site 1121335005009 CoA binding site [chemical binding]; other site 1121335005010 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1121335005011 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1121335005012 active site 1121335005013 HIGH motif; other site 1121335005014 dimer interface [polypeptide binding]; other site 1121335005015 KMSKS motif; other site 1121335005016 DNA polymerase IV; Reviewed; Region: PRK03103 1121335005017 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121335005018 active site 1121335005019 DNA binding site [nucleotide binding] 1121335005020 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1121335005021 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 1121335005022 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 1121335005023 CRISPR-associated endoribonuclease Cas6; Region: cas_cas6; TIGR01877 1121335005024 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1121335005025 putative efflux protein, MATE family; Region: matE; TIGR00797 1121335005026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335005027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005028 dimerization interface [polypeptide binding]; other site 1121335005029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335005030 dimer interface [polypeptide binding]; other site 1121335005031 phosphorylation site [posttranslational modification] 1121335005032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005033 ATP binding site [chemical binding]; other site 1121335005034 Mg2+ binding site [ion binding]; other site 1121335005035 G-X-G motif; other site 1121335005036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335005037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005038 active site 1121335005039 phosphorylation site [posttranslational modification] 1121335005040 intermolecular recognition site; other site 1121335005041 dimerization interface [polypeptide binding]; other site 1121335005042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335005043 DNA binding site [nucleotide binding] 1121335005044 thioredoxin 2; Provisional; Region: PRK10996 1121335005045 putative phosphate acyltransferase; Provisional; Region: PRK05331 1121335005046 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1121335005047 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1121335005048 active site 1121335005049 Zn binding site [ion binding]; other site 1121335005050 alpha-galactosidase; Region: PLN02808; cl17638 1121335005051 Cache domain; Region: Cache_1; pfam02743 1121335005052 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121335005053 HAMP domain; Region: HAMP; pfam00672 1121335005054 dimerization interface [polypeptide binding]; other site 1121335005055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005056 dimer interface [polypeptide binding]; other site 1121335005057 putative CheW interface [polypeptide binding]; other site 1121335005058 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1121335005059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335005060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005061 homodimer interface [polypeptide binding]; other site 1121335005062 catalytic residue [active] 1121335005063 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121335005064 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121335005065 Walker A/P-loop; other site 1121335005066 ATP binding site [chemical binding]; other site 1121335005067 Q-loop/lid; other site 1121335005068 ABC transporter signature motif; other site 1121335005069 Walker B; other site 1121335005070 D-loop; other site 1121335005071 H-loop/switch region; other site 1121335005072 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121335005073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005074 dimer interface [polypeptide binding]; other site 1121335005075 conserved gate region; other site 1121335005076 putative PBP binding loops; other site 1121335005077 ABC-ATPase subunit interface; other site 1121335005078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335005079 hinge residues; other site 1121335005080 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121335005081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335005082 substrate binding pocket [chemical binding]; other site 1121335005083 membrane-bound complex binding site; other site 1121335005084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005085 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335005086 active site 1121335005087 phosphorylation site [posttranslational modification] 1121335005088 intermolecular recognition site; other site 1121335005089 dimerization interface [polypeptide binding]; other site 1121335005090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335005091 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335005092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335005093 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335005094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005095 dimerization interface [polypeptide binding]; other site 1121335005096 Histidine kinase; Region: His_kinase; pfam06580 1121335005097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005098 ATP binding site [chemical binding]; other site 1121335005099 Mg2+ binding site [ion binding]; other site 1121335005100 G-X-G motif; other site 1121335005101 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335005102 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335005103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005104 dimer interface [polypeptide binding]; other site 1121335005105 conserved gate region; other site 1121335005106 putative PBP binding loops; other site 1121335005107 ABC-ATPase subunit interface; other site 1121335005108 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335005109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005110 dimer interface [polypeptide binding]; other site 1121335005111 conserved gate region; other site 1121335005112 putative PBP binding loops; other site 1121335005113 ABC-ATPase subunit interface; other site 1121335005114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335005115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335005116 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1121335005117 Walker A/P-loop; other site 1121335005118 ATP binding site [chemical binding]; other site 1121335005119 Q-loop/lid; other site 1121335005120 ABC transporter signature motif; other site 1121335005121 Walker B; other site 1121335005122 D-loop; other site 1121335005123 H-loop/switch region; other site 1121335005124 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1121335005125 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1121335005126 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1121335005127 threonyl-tRNA synthetase; Region: PLN02908 1121335005128 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1121335005129 dimer interface [polypeptide binding]; other site 1121335005130 substrate binding site [chemical binding]; other site 1121335005131 metal binding sites [ion binding]; metal-binding site 1121335005132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335005133 MULE transposase domain; Region: MULE; pfam10551 1121335005134 methyl-accepting with Cache sensor; COG:0840 Methyl-accepting chemotaxis protein; KO:K03406 methyl-accepting chemotaxis protein; ITERM:02328 methyl-accepting chemotaxis sensory transducer with Cache sensor; contains transmembrane domain; chemotaxis sensory transducer 1121335005135 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1121335005136 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005137 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005138 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005139 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121335005140 S-layer homology domain; Region: SLH; pfam00395 1121335005141 S-layer homology domain; Region: SLH; pfam00395 1121335005142 S-layer homology domain; Region: SLH; pfam00395 1121335005143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005144 dimerization interface [polypeptide binding]; other site 1121335005145 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005147 dimer interface [polypeptide binding]; other site 1121335005148 putative CheW interface [polypeptide binding]; other site 1121335005149 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 1121335005150 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335005151 active site 1121335005152 HIGH motif; other site 1121335005153 nucleotide binding site [chemical binding]; other site 1121335005154 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121335005155 KMSKS motif; other site 1121335005156 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121335005157 tRNA binding surface [nucleotide binding]; other site 1121335005158 anticodon binding site; other site 1121335005159 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1121335005160 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121335005161 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121335005162 active site 1121335005163 dimer interface [polypeptide binding]; other site 1121335005164 motif 1; other site 1121335005165 motif 2; other site 1121335005166 motif 3; other site 1121335005167 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121335005168 anticodon binding site; other site 1121335005169 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1121335005170 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1121335005171 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1121335005172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335005173 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335005174 DNA binding residues [nucleotide binding] 1121335005175 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1121335005176 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1121335005177 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1121335005178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335005179 Walker A/P-loop; other site 1121335005180 ATP binding site [chemical binding]; other site 1121335005181 Q-loop/lid; other site 1121335005182 ABC transporter signature motif; other site 1121335005183 Walker B; other site 1121335005184 D-loop; other site 1121335005185 H-loop/switch region; other site 1121335005186 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121335005187 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121335005188 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1121335005189 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1121335005190 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1121335005191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335005192 putative substrate translocation pore; other site 1121335005193 S-layer homology domain; Region: SLH; pfam00395 1121335005194 S-layer homology domain; Region: SLH; pfam00395 1121335005195 S-layer homology domain; Region: SLH; pfam00395 1121335005196 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1121335005197 active site 1121335005198 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1121335005199 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1121335005200 Rubredoxin [Energy production and conversion]; Region: COG1773 1121335005201 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 1121335005202 iron binding site [ion binding]; other site 1121335005203 Rubrerythrin [Energy production and conversion]; Region: COG1592 1121335005204 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1121335005205 binuclear metal center [ion binding]; other site 1121335005206 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1121335005207 iron binding site [ion binding]; other site 1121335005208 Cupin domain; Region: Cupin_2; cl17218 1121335005209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335005210 binding surface 1121335005211 TPR motif; other site 1121335005212 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1121335005213 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121335005214 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121335005215 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121335005216 catalytic residue [active] 1121335005217 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1121335005218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335005219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335005220 DNA binding residues [nucleotide binding] 1121335005221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335005222 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121335005223 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121335005224 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121335005225 putative acyl-acceptor binding pocket; other site 1121335005226 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1121335005227 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1121335005228 NAD binding site [chemical binding]; other site 1121335005229 ligand binding site [chemical binding]; other site 1121335005230 catalytic site [active] 1121335005231 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121335005232 transmembrane helices; other site 1121335005233 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1121335005234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1121335005235 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1121335005236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335005237 putative substrate translocation pore; other site 1121335005238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335005239 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121335005240 Predicted flavoprotein [General function prediction only]; Region: COG0431 1121335005241 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335005242 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335005243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335005244 Walker A/P-loop; other site 1121335005245 ATP binding site [chemical binding]; other site 1121335005246 Q-loop/lid; other site 1121335005247 ABC transporter signature motif; other site 1121335005248 Walker B; other site 1121335005249 D-loop; other site 1121335005250 H-loop/switch region; other site 1121335005251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335005252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335005253 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335005254 Walker A/P-loop; other site 1121335005255 ATP binding site [chemical binding]; other site 1121335005256 Q-loop/lid; other site 1121335005257 ABC transporter signature motif; other site 1121335005258 Walker B; other site 1121335005259 D-loop; other site 1121335005260 H-loop/switch region; other site 1121335005261 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121335005262 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1121335005263 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121335005264 FeoA domain; Region: FeoA; pfam04023 1121335005265 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1121335005266 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121335005267 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121335005268 G1 box; other site 1121335005269 GTP/Mg2+ binding site [chemical binding]; other site 1121335005270 Switch I region; other site 1121335005271 G2 box; other site 1121335005272 G3 box; other site 1121335005273 Switch II region; other site 1121335005274 G4 box; other site 1121335005275 G5 box; other site 1121335005276 Nucleoside recognition; Region: Gate; pfam07670 1121335005277 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121335005278 Nucleoside recognition; Region: Gate; pfam07670 1121335005279 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1121335005280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121335005281 NAD(P) binding site [chemical binding]; other site 1121335005282 active site 1121335005283 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1121335005284 putative deacylase active site [active] 1121335005285 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1121335005286 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1121335005287 Cache domain; Region: Cache_1; pfam02743 1121335005288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005289 dimerization interface [polypeptide binding]; other site 1121335005290 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005292 dimer interface [polypeptide binding]; other site 1121335005293 putative CheW interface [polypeptide binding]; other site 1121335005294 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1121335005295 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1121335005296 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1121335005297 putative metal binding residues [ion binding]; other site 1121335005298 signature motif; other site 1121335005299 dimer interface [polypeptide binding]; other site 1121335005300 active site 1121335005301 polyP binding site; other site 1121335005302 substrate binding site [chemical binding]; other site 1121335005303 acceptor-phosphate pocket; other site 1121335005304 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1121335005305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005306 active site 1121335005307 phosphorylation site [posttranslational modification] 1121335005308 intermolecular recognition site; other site 1121335005309 dimerization interface [polypeptide binding]; other site 1121335005310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335005311 DNA binding site [nucleotide binding] 1121335005312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335005313 dimer interface [polypeptide binding]; other site 1121335005314 phosphorylation site [posttranslational modification] 1121335005315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005316 ATP binding site [chemical binding]; other site 1121335005317 Mg2+ binding site [ion binding]; other site 1121335005318 G-X-G motif; other site 1121335005319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005320 dimerization interface [polypeptide binding]; other site 1121335005321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005322 dimer interface [polypeptide binding]; other site 1121335005323 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1121335005324 putative CheW interface [polypeptide binding]; other site 1121335005325 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121335005326 putative CheA interaction surface; other site 1121335005327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335005328 non-specific DNA binding site [nucleotide binding]; other site 1121335005329 salt bridge; other site 1121335005330 sequence-specific DNA binding site [nucleotide binding]; other site 1121335005331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1121335005332 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1121335005333 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1121335005334 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1121335005335 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121335005336 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121335005337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005338 active site 1121335005339 phosphorylation site [posttranslational modification] 1121335005340 intermolecular recognition site; other site 1121335005341 dimerization interface [polypeptide binding]; other site 1121335005342 CheB methylesterase; Region: CheB_methylest; pfam01339 1121335005343 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121335005344 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121335005345 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121335005346 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121335005347 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121335005348 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121335005349 putative binding surface; other site 1121335005350 active site 1121335005351 P2 response regulator binding domain; Region: P2; pfam07194 1121335005352 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121335005353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005354 ATP binding site [chemical binding]; other site 1121335005355 Mg2+ binding site [ion binding]; other site 1121335005356 G-X-G motif; other site 1121335005357 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121335005358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121335005359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335005360 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121335005361 active site 1121335005362 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1121335005363 dimer interface [polypeptide binding]; other site 1121335005364 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121335005365 Ligand Binding Site [chemical binding]; other site 1121335005366 Molecular Tunnel; other site 1121335005367 CTP synthetase; Validated; Region: pyrG; PRK05380 1121335005368 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1121335005369 Catalytic site [active] 1121335005370 active site 1121335005371 UTP binding site [chemical binding]; other site 1121335005372 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1121335005373 active site 1121335005374 putative oxyanion hole; other site 1121335005375 catalytic triad [active] 1121335005376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005377 phosphorylation site [posttranslational modification] 1121335005378 intermolecular recognition site; other site 1121335005379 ANTAR domain; Region: ANTAR; pfam03861 1121335005380 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1121335005381 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121335005382 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335005383 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1121335005384 domain_subunit interface; other site 1121335005385 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121335005386 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1121335005387 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1121335005388 active site 1121335005389 FMN binding site [chemical binding]; other site 1121335005390 substrate binding site [chemical binding]; other site 1121335005391 3Fe-4S cluster binding site [ion binding]; other site 1121335005392 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1121335005393 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1121335005394 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1121335005395 putative active site [active] 1121335005396 asparagine synthetase AsnA; Provisional; Region: PRK05425 1121335005397 motif 1; other site 1121335005398 dimer interface [polypeptide binding]; other site 1121335005399 active site 1121335005400 motif 2; other site 1121335005401 motif 3; other site 1121335005402 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121335005403 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121335005404 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335005405 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1121335005406 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1121335005407 GDP-binding site [chemical binding]; other site 1121335005408 ACT binding site; other site 1121335005409 IMP binding site; other site 1121335005410 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121335005411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005412 active site 1121335005413 phosphorylation site [posttranslational modification] 1121335005414 intermolecular recognition site; other site 1121335005415 dimerization interface [polypeptide binding]; other site 1121335005416 CheB methylesterase; Region: CheB_methylest; pfam01339 1121335005417 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121335005418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005419 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121335005420 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005422 dimer interface [polypeptide binding]; other site 1121335005423 putative CheW interface [polypeptide binding]; other site 1121335005424 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005426 dimer interface [polypeptide binding]; other site 1121335005427 putative CheW interface [polypeptide binding]; other site 1121335005428 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005429 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005431 dimer interface [polypeptide binding]; other site 1121335005432 putative CheW interface [polypeptide binding]; other site 1121335005433 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005434 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121335005435 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121335005436 putative binding surface; other site 1121335005437 active site 1121335005438 P2 response regulator binding domain; Region: P2; pfam07194 1121335005439 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121335005440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005441 ATP binding site [chemical binding]; other site 1121335005442 Mg2+ binding site [ion binding]; other site 1121335005443 G-X-G motif; other site 1121335005444 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121335005445 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121335005446 putative CheA interaction surface; other site 1121335005447 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335005448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005449 active site 1121335005450 phosphorylation site [posttranslational modification] 1121335005451 intermolecular recognition site; other site 1121335005452 dimerization interface [polypeptide binding]; other site 1121335005453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121335005454 active site 1121335005455 DNA binding site [nucleotide binding] 1121335005456 Int/Topo IB signature motif; other site 1121335005457 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1121335005458 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1121335005459 dimer interface [polypeptide binding]; other site 1121335005460 active site 1121335005461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335005462 catalytic residues [active] 1121335005463 substrate binding site [chemical binding]; other site 1121335005464 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1121335005465 agmatinase; Region: agmatinase; TIGR01230 1121335005466 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1121335005467 putative active site [active] 1121335005468 Mn binding site [ion binding]; other site 1121335005469 spermidine synthase; Provisional; Region: PRK00811 1121335005470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005471 S-adenosylmethionine binding site [chemical binding]; other site 1121335005472 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1121335005473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121335005474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335005475 catalytic residue [active] 1121335005476 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1121335005477 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1121335005478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335005479 Zn2+ binding site [ion binding]; other site 1121335005480 Mg2+ binding site [ion binding]; other site 1121335005481 COG:0030 Dimethyladenosine transferase; hypothetical protein 1121335005482 S-layer homology domain; Region: SLH; pfam00395 1121335005483 MULE transposase domain; Region: MULE; pfam10551 1121335005484 MULE transposase domain; Region: MULE; pfam10551 1121335005485 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 1121335005486 PLD-like domain; Region: PLDc_2; pfam13091 1121335005487 putative active site [active] 1121335005488 catalytic site [active] 1121335005489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335005490 ATP binding site [chemical binding]; other site 1121335005491 putative Mg++ binding site [ion binding]; other site 1121335005492 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1121335005493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335005494 nucleotide binding region [chemical binding]; other site 1121335005495 ATP-binding site [chemical binding]; other site 1121335005496 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1121335005497 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1121335005498 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1121335005499 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 1121335005500 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1121335005501 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335005502 MULE transposase domain; Region: MULE; pfam10551 1121335005503 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1121335005504 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1121335005505 glutaminase active site [active] 1121335005506 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1121335005507 dimer interface [polypeptide binding]; other site 1121335005508 active site 1121335005509 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1121335005510 dimer interface [polypeptide binding]; other site 1121335005511 active site 1121335005512 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335005513 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1121335005514 or inactivated derivative; COG:3328 Transposase and inactivated derivatives; transposase 1121335005515 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335005516 MULE transposase domain; Region: MULE; pfam10551 1121335005517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121335005518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121335005519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121335005520 dimerization interface [polypeptide binding]; other site 1121335005521 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1121335005522 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1121335005523 Cache domain; Region: Cache_1; pfam02743 1121335005524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005525 dimerization interface [polypeptide binding]; other site 1121335005526 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005527 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005528 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005529 dimer interface [polypeptide binding]; other site 1121335005530 putative CheW interface [polypeptide binding]; other site 1121335005531 GGDEF domain; COG:3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; diguanylate cyclase 1121335005532 PAS domain S-box; Region: sensory_box; TIGR00229 1121335005533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335005534 putative active site [active] 1121335005535 heme pocket [chemical binding]; other site 1121335005536 predicted nonfunctional due to frameshift; 5-nucleotidase 1121335005537 Protein of unknown function (DUF511); Region: DUF511; pfam04373 1121335005538 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1121335005539 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1121335005540 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1121335005541 putative active site [active] 1121335005542 oxyanion strand; other site 1121335005543 catalytic triad [active] 1121335005544 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121335005545 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121335005546 substrate binding site [chemical binding]; other site 1121335005547 glutamase interaction surface [polypeptide binding]; other site 1121335005548 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1121335005549 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1121335005550 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121335005551 dimer interface [polypeptide binding]; other site 1121335005552 substrate binding site [chemical binding]; other site 1121335005553 ATP binding site [chemical binding]; other site 1121335005554 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121335005555 dimer interface [polypeptide binding]; other site 1121335005556 substrate binding site [chemical binding]; other site 1121335005557 ATP binding site [chemical binding]; other site 1121335005558 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335005559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335005560 motif II; other site 1121335005561 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1121335005562 thiamine phosphate binding site [chemical binding]; other site 1121335005563 active site 1121335005564 pyrophosphate binding site [ion binding]; other site 1121335005565 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1121335005566 substrate binding site [chemical binding]; other site 1121335005567 multimerization interface [polypeptide binding]; other site 1121335005568 ATP binding site [chemical binding]; other site 1121335005569 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1121335005570 PUA domain; Region: PUA; cl00607 1121335005571 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1121335005572 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1121335005573 putative RNA binding site [nucleotide binding]; other site 1121335005574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005575 S-adenosylmethionine binding site [chemical binding]; other site 1121335005576 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1121335005577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335005578 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121335005579 HAMP domain; Region: HAMP; pfam00672 1121335005580 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005582 dimer interface [polypeptide binding]; other site 1121335005583 putative CheW interface [polypeptide binding]; other site 1121335005584 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121335005585 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1121335005586 ArsC family; Region: ArsC; pfam03960 1121335005587 putative ArsC-like catalytic residues; other site 1121335005588 putative TRX-like catalytic residues [active] 1121335005589 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1121335005590 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1121335005591 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121335005592 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1121335005593 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121335005594 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1121335005595 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1121335005596 diiron binding motif [ion binding]; other site 1121335005597 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 1121335005598 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1121335005599 Predicted membrane protein [Function unknown]; Region: COG1511 1121335005600 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1121335005601 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1121335005602 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1121335005603 active site 1121335005604 catalytic site [active] 1121335005605 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 1121335005606 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1121335005607 carbohydrate binding site [chemical binding]; other site 1121335005608 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1121335005609 carbohydrate binding site [chemical binding]; other site 1121335005610 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1121335005611 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1121335005612 Ca binding site [ion binding]; other site 1121335005613 active site 1121335005614 catalytic site [active] 1121335005615 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1121335005616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005617 S-adenosylmethionine binding site [chemical binding]; other site 1121335005618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005619 S-adenosylmethionine binding site [chemical binding]; other site 1121335005620 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1121335005621 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121335005622 intersubunit interface [polypeptide binding]; other site 1121335005623 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1121335005624 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121335005625 Walker A/P-loop; other site 1121335005626 ATP binding site [chemical binding]; other site 1121335005627 Q-loop/lid; other site 1121335005628 ABC transporter signature motif; other site 1121335005629 Walker B; other site 1121335005630 D-loop; other site 1121335005631 H-loop/switch region; other site 1121335005632 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121335005633 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335005634 ABC-ATPase subunit interface; other site 1121335005635 dimer interface [polypeptide binding]; other site 1121335005636 putative PBP binding regions; other site 1121335005637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335005638 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121335005639 ABC-ATPase subunit interface; other site 1121335005640 dimer interface [polypeptide binding]; other site 1121335005641 putative PBP binding regions; other site 1121335005642 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335005643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335005644 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1121335005645 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121335005646 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121335005647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1121335005648 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1121335005649 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1121335005650 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121335005651 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121335005652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005653 dimer interface [polypeptide binding]; other site 1121335005654 conserved gate region; other site 1121335005655 putative PBP binding loops; other site 1121335005656 ABC-ATPase subunit interface; other site 1121335005657 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121335005658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005659 dimer interface [polypeptide binding]; other site 1121335005660 conserved gate region; other site 1121335005661 putative PBP binding loops; other site 1121335005662 ABC-ATPase subunit interface; other site 1121335005663 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121335005664 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121335005665 Walker A/P-loop; other site 1121335005666 ATP binding site [chemical binding]; other site 1121335005667 Q-loop/lid; other site 1121335005668 ABC transporter signature motif; other site 1121335005669 Walker B; other site 1121335005670 D-loop; other site 1121335005671 H-loop/switch region; other site 1121335005672 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1121335005673 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121335005674 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121335005675 MarR family; Region: MarR_2; cl17246 1121335005676 MarR family; Region: MarR_2; cl17246 1121335005677 FeoA domain; Region: FeoA; pfam04023 1121335005678 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121335005679 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121335005680 G1 box; other site 1121335005681 GTP/Mg2+ binding site [chemical binding]; other site 1121335005682 Switch I region; other site 1121335005683 G2 box; other site 1121335005684 G3 box; other site 1121335005685 Switch II region; other site 1121335005686 G4 box; other site 1121335005687 G5 box; other site 1121335005688 Nucleoside recognition; Region: Gate; pfam07670 1121335005689 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121335005690 Nucleoside recognition; Region: Gate; pfam07670 1121335005691 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335005692 NPCBM/NEW2 domain; Region: NPCBM; cl07060 1121335005693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1121335005694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335005695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335005696 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 1121335005697 4Fe-4S binding domain; Region: Fer4; cl02805 1121335005698 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335005699 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335005700 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1121335005701 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1121335005702 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335005703 Putative Fe-S cluster; Region: FeS; cl17515 1121335005704 PAS fold; Region: PAS; pfam00989 1121335005705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335005706 putative active site [active] 1121335005707 heme pocket [chemical binding]; other site 1121335005708 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335005709 dimer interface [polypeptide binding]; other site 1121335005710 [2Fe-2S] cluster binding site [ion binding]; other site 1121335005711 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335005712 dimer interface [polypeptide binding]; other site 1121335005713 [2Fe-2S] cluster binding site [ion binding]; other site 1121335005714 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1121335005715 active site 1121335005716 substrate binding site [chemical binding]; other site 1121335005717 Phosphotransferase enzyme family; Region: APH; pfam01636 1121335005718 ATP binding site [chemical binding]; other site 1121335005719 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1121335005720 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1121335005721 putative catalytic cysteine [active] 1121335005722 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1121335005723 putative active site [active] 1121335005724 metal binding site [ion binding]; metal-binding site 1121335005725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121335005726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121335005727 Cache domain; Region: Cache_1; pfam02743 1121335005728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335005729 dimerization interface [polypeptide binding]; other site 1121335005730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335005731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335005732 dimer interface [polypeptide binding]; other site 1121335005733 putative CheW interface [polypeptide binding]; other site 1121335005734 conserved hypothetical integral membrane protein; Region: TIGR03766 1121335005735 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121335005736 dimer interface [polypeptide binding]; other site 1121335005737 [2Fe-2S] cluster binding site [ion binding]; other site 1121335005738 Flavin Reductases; Region: FlaRed; cl00801 1121335005739 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1121335005740 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 1121335005741 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 1121335005742 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1121335005743 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 1121335005744 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1121335005745 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1121335005746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121335005747 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1121335005748 endoglucanase; Region: PLN02420 1121335005749 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 1121335005750 Cellulose binding domain; Region: CBM_3; pfam00942 1121335005751 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1121335005752 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1121335005753 Cellulose binding domain; Region: CBM_3; pfam00942 1121335005754 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 1121335005755 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1121335005756 Cellulose binding domain; Region: CBM_3; pfam00942 1121335005757 Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998 1121335005758 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1121335005759 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1121335005760 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1121335005761 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1121335005762 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1121335005763 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1121335005764 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1121335005765 putative dimer interface [polypeptide binding]; other site 1121335005766 catalytic triad [active] 1121335005767 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335005768 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1121335005769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335005770 motif II; other site 1121335005771 FtsH Extracellular; Region: FtsH_ext; pfam06480 1121335005772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335005773 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121335005774 Walker A motif; other site 1121335005775 ATP binding site [chemical binding]; other site 1121335005776 Walker B motif; other site 1121335005777 arginine finger; other site 1121335005778 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335005779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335005780 FeS/SAM binding site; other site 1121335005781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335005782 hypothetical protein 1121335005783 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121335005784 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121335005785 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121335005786 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335005787 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1121335005788 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1121335005789 GatB domain; Region: GatB_Yqey; smart00845 1121335005790 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121335005791 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1121335005792 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1121335005793 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121335005794 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121335005795 dimer interface [polypeptide binding]; other site 1121335005796 anticodon binding site; other site 1121335005797 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121335005798 homodimer interface [polypeptide binding]; other site 1121335005799 motif 1; other site 1121335005800 active site 1121335005801 motif 2; other site 1121335005802 GAD domain; Region: GAD; pfam02938 1121335005803 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335005804 active site 1121335005805 motif 3; other site 1121335005806 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1121335005807 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121335005808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335005809 putative DNA binding site [nucleotide binding]; other site 1121335005810 putative Zn2+ binding site [ion binding]; other site 1121335005811 contains transmembrane domain; hypothetical protein 1121335005812 contains signal peptide; contains transmembrane domain; hypothetical protein 1121335005813 COG:3421 Uncharacterized protein conserved in bacteria; hypothetical protein 1121335005814 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1121335005815 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335005816 metal binding site [ion binding]; metal-binding site 1121335005817 ligand binding site [chemical binding]; other site 1121335005818 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335005819 metal binding site [ion binding]; metal-binding site 1121335005820 ligand binding site [chemical binding]; other site 1121335005821 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1121335005822 metal binding site [ion binding]; metal-binding site 1121335005823 ligand binding site [chemical binding]; other site 1121335005824 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 1121335005825 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 1121335005826 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 1121335005827 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121335005828 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121335005829 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335005830 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121335005831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335005832 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121335005833 Coenzyme A binding pocket [chemical binding]; other site 1121335005834 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1121335005835 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1121335005836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121335005837 HTH-like domain; Region: HTH_21; pfam13276 1121335005838 Integrase core domain; Region: rve; pfam00665 1121335005839 Integrase core domain; Region: rve_3; pfam13683 1121335005840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335005841 MULE transposase domain; Region: MULE; pfam10551 1121335005842 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121335005843 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1121335005844 catalytic residues [active] 1121335005845 catalytic nucleophile [active] 1121335005846 Recombinase; Region: Recombinase; pfam07508 1121335005847 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1121335005848 TRAM domain; Region: TRAM; cl01282 1121335005849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005850 S-adenosylmethionine binding site [chemical binding]; other site 1121335005851 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121335005852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335005853 non-specific DNA binding site [nucleotide binding]; other site 1121335005854 salt bridge; other site 1121335005855 sequence-specific DNA binding site [nucleotide binding]; other site 1121335005856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335005857 active site 1121335005858 phosphorylation site [posttranslational modification] 1121335005859 intermolecular recognition site; other site 1121335005860 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1121335005861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1121335005862 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335005863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335005864 S-adenosylmethionine binding site [chemical binding]; other site 1121335005865 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335005866 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335005867 Walker A/P-loop; other site 1121335005868 ATP binding site [chemical binding]; other site 1121335005869 Q-loop/lid; other site 1121335005870 ABC transporter signature motif; other site 1121335005871 Walker B; other site 1121335005872 D-loop; other site 1121335005873 H-loop/switch region; other site 1121335005874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335005875 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335005876 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335005877 NMT1-like family; Region: NMT1_2; pfam13379 1121335005878 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121335005879 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 1121335005880 ACS interaction site; other site 1121335005881 CODH interaction site; other site 1121335005882 metal cluster binding site [ion binding]; other site 1121335005883 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121335005884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335005885 Coenzyme A binding pocket [chemical binding]; other site 1121335005886 YibE/F-like protein; Region: YibE_F; pfam07907 1121335005887 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1121335005888 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121335005889 dimer interface [polypeptide binding]; other site 1121335005890 active site 1121335005891 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121335005892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335005893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335005894 dimer interface [polypeptide binding]; other site 1121335005895 phosphorylation site [posttranslational modification] 1121335005896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335005897 HAMP domain; Region: HAMP; pfam00672 1121335005898 dimerization interface [polypeptide binding]; other site 1121335005899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335005900 dimer interface [polypeptide binding]; other site 1121335005901 phosphorylation site [posttranslational modification] 1121335005902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335005903 ATP binding site [chemical binding]; other site 1121335005904 Mg2+ binding site [ion binding]; other site 1121335005905 G-X-G motif; other site 1121335005906 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121335005907 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121335005908 dimer interface [polypeptide binding]; other site 1121335005909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005910 catalytic residue [active] 1121335005911 Predicted transcriptional regulator [Transcription]; Region: COG1959 1121335005912 Transcriptional regulator; Region: Rrf2; cl17282 1121335005913 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1121335005914 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121335005915 homodimer interface [polypeptide binding]; other site 1121335005916 substrate-cofactor binding pocket; other site 1121335005917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005918 catalytic residue [active] 1121335005919 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1121335005920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335005921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005922 homodimer interface [polypeptide binding]; other site 1121335005923 catalytic residue [active] 1121335005924 'predicted nonfunctional due to frameshift; C39-like family'; COG:2195 Di- and tripeptidases; peptidase 1121335005925 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121335005926 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1121335005927 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121335005928 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1121335005929 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 1121335005930 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335005931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335005932 FeS/SAM binding site; other site 1121335005933 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1121335005934 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121335005935 homodimer interface [polypeptide binding]; other site 1121335005936 substrate-cofactor binding pocket; other site 1121335005937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335005938 catalytic residue [active] 1121335005939 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1121335005940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121335005941 substrate binding pocket [chemical binding]; other site 1121335005942 membrane-bound complex binding site; other site 1121335005943 hinge residues; other site 1121335005944 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1121335005945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335005946 dimer interface [polypeptide binding]; other site 1121335005947 conserved gate region; other site 1121335005948 putative PBP binding loops; other site 1121335005949 ABC-ATPase subunit interface; other site 1121335005950 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1121335005951 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1121335005952 Walker A/P-loop; other site 1121335005953 ATP binding site [chemical binding]; other site 1121335005954 Q-loop/lid; other site 1121335005955 ABC transporter signature motif; other site 1121335005956 Walker B; other site 1121335005957 D-loop; other site 1121335005958 H-loop/switch region; other site 1121335005959 nitrogenase iron protein; Region: nifH; TIGR01287 1121335005960 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1121335005961 Nucleotide-binding sites [chemical binding]; other site 1121335005962 Walker A motif; other site 1121335005963 Switch I region of nucleotide binding site; other site 1121335005964 Fe4S4 binding sites [ion binding]; other site 1121335005965 Switch II region of nucleotide binding site; other site 1121335005966 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121335005967 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121335005968 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121335005969 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1121335005970 active site 1121335005971 trimer interface [polypeptide binding]; other site 1121335005972 allosteric site; other site 1121335005973 active site lid [active] 1121335005974 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1121335005975 MgtE intracellular N domain; Region: MgtE_N; smart00924 1121335005976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1121335005977 Divalent cation transporter; Region: MgtE; pfam01769 1121335005978 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121335005979 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121335005980 G1 box; other site 1121335005981 GTP/Mg2+ binding site [chemical binding]; other site 1121335005982 Switch I region; other site 1121335005983 G2 box; other site 1121335005984 G3 box; other site 1121335005985 Switch II region; other site 1121335005986 G4 box; other site 1121335005987 G5 box; other site 1121335005988 Nucleoside recognition; Region: Gate; pfam07670 1121335005989 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121335005990 Nucleoside recognition; Region: Gate; pfam07670 1121335005991 FeoA domain; Region: FeoA; pfam04023 1121335005992 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1121335005993 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1121335005994 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121335005995 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1121335005996 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1121335005997 G1 box; other site 1121335005998 putative GEF interaction site [polypeptide binding]; other site 1121335005999 GTP/Mg2+ binding site [chemical binding]; other site 1121335006000 Switch I region; other site 1121335006001 G2 box; other site 1121335006002 G3 box; other site 1121335006003 Switch II region; other site 1121335006004 G4 box; other site 1121335006005 G5 box; other site 1121335006006 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1121335006007 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1121335006008 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1121335006009 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1121335006010 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1121335006011 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1121335006012 active site 1121335006013 dimer interface [polypeptide binding]; other site 1121335006014 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121335006015 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121335006016 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1121335006017 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1121335006018 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1121335006019 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121335006020 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121335006021 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1121335006022 GTP-binding protein Der; Reviewed; Region: PRK00093 1121335006023 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1121335006024 G1 box; other site 1121335006025 GTP/Mg2+ binding site [chemical binding]; other site 1121335006026 Switch I region; other site 1121335006027 G2 box; other site 1121335006028 Switch II region; other site 1121335006029 G3 box; other site 1121335006030 G4 box; other site 1121335006031 G5 box; other site 1121335006032 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1121335006033 G1 box; other site 1121335006034 GTP/Mg2+ binding site [chemical binding]; other site 1121335006035 Switch I region; other site 1121335006036 G2 box; other site 1121335006037 G3 box; other site 1121335006038 Switch II region; other site 1121335006039 G4 box; other site 1121335006040 G5 box; other site 1121335006041 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1121335006042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1121335006043 active site 1121335006044 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335006045 substrate binding site [chemical binding]; other site 1121335006046 catalytic residues [active] 1121335006047 dimer interface [polypeptide binding]; other site 1121335006048 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1121335006049 core dimer interface [polypeptide binding]; other site 1121335006050 peripheral dimer interface [polypeptide binding]; other site 1121335006051 L10 interface [polypeptide binding]; other site 1121335006052 L11 interface [polypeptide binding]; other site 1121335006053 putative EF-Tu interaction site [polypeptide binding]; other site 1121335006054 putative EF-G interaction site [polypeptide binding]; other site 1121335006055 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1121335006056 23S rRNA interface [nucleotide binding]; other site 1121335006057 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1121335006058 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1121335006059 mRNA/rRNA interface [nucleotide binding]; other site 1121335006060 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1121335006061 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1121335006062 23S rRNA interface [nucleotide binding]; other site 1121335006063 L7/L12 interface [polypeptide binding]; other site 1121335006064 putative thiostrepton binding site; other site 1121335006065 L25 interface [polypeptide binding]; other site 1121335006066 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1121335006067 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1121335006068 putative homodimer interface [polypeptide binding]; other site 1121335006069 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121335006070 heterodimer interface [polypeptide binding]; other site 1121335006071 homodimer interface [polypeptide binding]; other site 1121335006072 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1121335006073 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1121335006074 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1121335006075 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1121335006076 substrate binding site [chemical binding]; other site 1121335006077 active site 1121335006078 catalytic residues [active] 1121335006079 heterodimer interface [polypeptide binding]; other site 1121335006080 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1121335006081 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1121335006082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335006083 catalytic residue [active] 1121335006084 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1121335006085 active site 1121335006086 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1121335006087 active site 1121335006088 ribulose/triose binding site [chemical binding]; other site 1121335006089 phosphate binding site [ion binding]; other site 1121335006090 substrate (anthranilate) binding pocket [chemical binding]; other site 1121335006091 product (indole) binding pocket [chemical binding]; other site 1121335006092 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1121335006093 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121335006094 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121335006095 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121335006096 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1121335006097 glutamine binding [chemical binding]; other site 1121335006098 catalytic triad [active] 1121335006099 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1121335006100 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1121335006101 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121335006102 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1121335006103 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121335006104 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121335006105 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121335006106 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1121335006107 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121335006108 motif 1; other site 1121335006109 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1121335006110 active site 1121335006111 motif 2; other site 1121335006112 motif 3; other site 1121335006113 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1121335006114 anticodon binding site; other site 1121335006115 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1121335006116 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1121335006117 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1121335006118 catalytic site [active] 1121335006119 G-X2-G-X-G-K; other site 1121335006120 hypothetical protein; Provisional; Region: PRK04323 1121335006121 hypothetical protein; Provisional; Region: PRK11820 1121335006122 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1121335006123 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1121335006124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006125 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335006126 active site 1121335006127 phosphorylation site [posttranslational modification] 1121335006128 intermolecular recognition site; other site 1121335006129 dimerization interface [polypeptide binding]; other site 1121335006130 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1121335006131 RNA methyltransferase, RsmE family; Region: TIGR00046 1121335006132 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1121335006133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335006134 S-adenosylmethionine binding site [chemical binding]; other site 1121335006135 chaperone protein DnaJ; Provisional; Region: PRK14277 1121335006136 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335006137 HSP70 interaction site [polypeptide binding]; other site 1121335006138 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1121335006139 substrate binding site [polypeptide binding]; other site 1121335006140 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121335006141 Zn binding sites [ion binding]; other site 1121335006142 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121335006143 dimer interface [polypeptide binding]; other site 1121335006144 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1121335006145 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1121335006146 nucleotide binding site [chemical binding]; other site 1121335006147 NEF interaction site [polypeptide binding]; other site 1121335006148 SBD interface [polypeptide binding]; other site 1121335006149 heat shock protein GrpE; Provisional; Region: PRK14140 1121335006150 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1121335006151 dimer interface [polypeptide binding]; other site 1121335006152 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1121335006153 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1121335006154 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1121335006155 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 1121335006156 HemN C-terminal domain; Region: HemN_C; pfam06969 1121335006157 GTP-binding protein LepA; Provisional; Region: PRK05433 1121335006158 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1121335006159 G1 box; other site 1121335006160 putative GEF interaction site [polypeptide binding]; other site 1121335006161 GTP/Mg2+ binding site [chemical binding]; other site 1121335006162 Switch I region; other site 1121335006163 G2 box; other site 1121335006164 G3 box; other site 1121335006165 Switch II region; other site 1121335006166 G4 box; other site 1121335006167 G5 box; other site 1121335006168 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1121335006169 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1121335006170 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1121335006171 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121335006172 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1121335006173 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1121335006174 ligand binding site [chemical binding]; other site 1121335006175 active site 1121335006176 excinuclease ABC subunit B; Provisional; Region: PRK05298 1121335006177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335006178 ATP binding site [chemical binding]; other site 1121335006179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335006180 nucleotide binding region [chemical binding]; other site 1121335006181 ATP-binding site [chemical binding]; other site 1121335006182 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1121335006183 Recombination protein O N terminal; Region: RecO_N; pfam11967 1121335006184 DNA repair protein RecO; Region: reco; TIGR00613 1121335006185 Recombination protein O C terminal; Region: RecO_C; pfam02565 1121335006186 YqzL-like protein; Region: YqzL; pfam14006 1121335006187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1121335006188 hypothetical protein; Provisional; Region: PRK13663 1121335006189 GTPase Era; Reviewed; Region: era; PRK00089 1121335006190 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1121335006191 G1 box; other site 1121335006192 GTP/Mg2+ binding site [chemical binding]; other site 1121335006193 Switch I region; other site 1121335006194 G2 box; other site 1121335006195 Switch II region; other site 1121335006196 G3 box; other site 1121335006197 G4 box; other site 1121335006198 G5 box; other site 1121335006199 KH domain; Region: KH_2; pfam07650 1121335006200 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1121335006201 active site 1121335006202 catalytic motif [active] 1121335006203 Zn binding site [ion binding]; other site 1121335006204 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1121335006205 Na2 binding site [ion binding]; other site 1121335006206 putative substrate binding site 1 [chemical binding]; other site 1121335006207 Na binding site 1 [ion binding]; other site 1121335006208 putative substrate binding site 2 [chemical binding]; other site 1121335006209 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1121335006210 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335006211 Clp amino terminal domain; Region: Clp_N; pfam02861 1121335006212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335006213 Walker A motif; other site 1121335006214 ATP binding site [chemical binding]; other site 1121335006215 Walker B motif; other site 1121335006216 arginine finger; other site 1121335006217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335006218 Walker A motif; other site 1121335006219 ATP binding site [chemical binding]; other site 1121335006220 Walker B motif; other site 1121335006221 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121335006222 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1121335006223 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121335006224 HSP70 interaction site [polypeptide binding]; other site 1121335006225 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121335006226 substrate binding site [polypeptide binding]; other site 1121335006227 dimer interface [polypeptide binding]; other site 1121335006228 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1121335006229 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1121335006230 ligand binding site; other site 1121335006231 oligomer interface; other site 1121335006232 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1121335006233 dimer interface [polypeptide binding]; other site 1121335006234 N-terminal domain interface [polypeptide binding]; other site 1121335006235 sulfate 1 binding site; other site 1121335006236 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 1121335006237 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1121335006238 ligand binding site; other site 1121335006239 oligomer interface; other site 1121335006240 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1121335006241 dimer interface [polypeptide binding]; other site 1121335006242 N-terminal domain interface [polypeptide binding]; other site 1121335006243 sulfate 1 binding site; other site 1121335006244 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1121335006245 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1121335006246 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 1121335006247 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1121335006248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335006249 catalytic residue [active] 1121335006250 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1121335006251 active site 1121335006252 nucleophile elbow; other site 1121335006253 Thiamine pyrophosphokinase; Region: TPK; cd07995 1121335006254 active site 1121335006255 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1121335006256 dimerization interface [polypeptide binding]; other site 1121335006257 thiamine binding site [chemical binding]; other site 1121335006258 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1121335006259 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1121335006260 substrate binding site [chemical binding]; other site 1121335006261 hexamer interface [polypeptide binding]; other site 1121335006262 metal binding site [ion binding]; metal-binding site 1121335006263 GTPase RsgA; Reviewed; Region: PRK00098 1121335006264 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1121335006265 RNA binding site [nucleotide binding]; other site 1121335006266 homodimer interface [polypeptide binding]; other site 1121335006267 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1121335006268 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1121335006269 GTP/Mg2+ binding site [chemical binding]; other site 1121335006270 G4 box; other site 1121335006271 G5 box; other site 1121335006272 G1 box; other site 1121335006273 Switch I region; other site 1121335006274 G2 box; other site 1121335006275 G3 box; other site 1121335006276 Switch II region; other site 1121335006277 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121335006278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121335006279 active site 1121335006280 ATP binding site [chemical binding]; other site 1121335006281 substrate binding site [chemical binding]; other site 1121335006282 activation loop (A-loop); other site 1121335006283 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121335006284 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121335006285 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1121335006286 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121335006287 Protein phosphatase 2C; Region: PP2C; pfam00481 1121335006288 active site 1121335006289 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 1121335006290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006291 FeS/SAM binding site; other site 1121335006292 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1121335006293 NusB family; Region: NusB; pfam01029 1121335006294 putative RNA binding site [nucleotide binding]; other site 1121335006295 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1121335006296 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1121335006297 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1121335006298 active site 1121335006299 dimer interface [polypeptide binding]; other site 1121335006300 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1121335006301 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1121335006302 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121335006303 active site 1121335006304 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1121335006305 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1121335006306 GTP/Mg2+ binding site [chemical binding]; other site 1121335006307 G4 box; other site 1121335006308 G5 box; other site 1121335006309 G1 box; other site 1121335006310 Switch I region; other site 1121335006311 G2 box; other site 1121335006312 G3 box; other site 1121335006313 Switch II region; other site 1121335006314 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1121335006315 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1121335006316 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1121335006317 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1121335006318 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1121335006319 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PLN02538 1121335006320 triosephosphate isomerase; Provisional; Region: PRK14567 1121335006321 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1121335006322 substrate binding site [chemical binding]; other site 1121335006323 dimer interface [polypeptide binding]; other site 1121335006324 catalytic triad [active] 1121335006325 Phosphoglycerate kinase; Region: PGK; pfam00162 1121335006326 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1121335006327 substrate binding site [chemical binding]; other site 1121335006328 hinge regions; other site 1121335006329 ADP binding site [chemical binding]; other site 1121335006330 catalytic site [active] 1121335006331 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 1121335006332 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1121335006333 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121335006334 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121335006335 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1121335006336 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121335006337 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1121335006338 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1121335006339 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1121335006340 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1121335006341 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1121335006342 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1121335006343 Competence protein; Region: Competence; pfam03772 1121335006344 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1121335006345 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121335006346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335006347 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1121335006348 Coenzyme A binding pocket [chemical binding]; other site 1121335006349 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1121335006350 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121335006351 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1121335006352 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1121335006353 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1121335006354 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1121335006355 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1121335006356 NAD binding site [chemical binding]; other site 1121335006357 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335006358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335006359 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1121335006360 Walker A/P-loop; other site 1121335006361 ATP binding site [chemical binding]; other site 1121335006362 Q-loop/lid; other site 1121335006363 ABC transporter signature motif; other site 1121335006364 Walker B; other site 1121335006365 D-loop; other site 1121335006366 H-loop/switch region; other site 1121335006367 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335006368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335006369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335006370 Walker A/P-loop; other site 1121335006371 ATP binding site [chemical binding]; other site 1121335006372 Q-loop/lid; other site 1121335006373 ABC transporter signature motif; other site 1121335006374 Walker B; other site 1121335006375 D-loop; other site 1121335006376 H-loop/switch region; other site 1121335006377 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121335006378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121335006379 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335006380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335006381 motif II; other site 1121335006382 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1121335006383 active site 1121335006384 dimer interface [polypeptide binding]; other site 1121335006385 dihydroorotase; Validated; Region: pyrC; PRK09357 1121335006386 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121335006387 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1121335006388 active site 1121335006389 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1121335006390 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121335006391 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121335006392 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1121335006393 Protein export membrane protein; Region: SecD_SecF; cl14618 1121335006394 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1121335006395 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1121335006396 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 1121335006397 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 1121335006398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006399 FeS/SAM binding site; other site 1121335006400 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121335006401 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 1121335006402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335006403 non-specific DNA binding site [nucleotide binding]; other site 1121335006404 salt bridge; other site 1121335006405 sequence-specific DNA binding site [nucleotide binding]; other site 1121335006406 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1121335006407 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1121335006408 active site 1121335006409 HIGH motif; other site 1121335006410 dimer interface [polypeptide binding]; other site 1121335006411 KMSKS motif; other site 1121335006412 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335006413 RNA binding surface [nucleotide binding]; other site 1121335006414 Transglycosylase; Region: Transgly; pfam00912 1121335006415 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1121335006416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1121335006417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006418 active site 1121335006419 phosphorylation site [posttranslational modification] 1121335006420 intermolecular recognition site; other site 1121335006421 dimerization interface [polypeptide binding]; other site 1121335006422 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1121335006423 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1121335006424 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1121335006425 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 1121335006426 active site 1121335006427 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1121335006428 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1121335006429 folate binding site [chemical binding]; other site 1121335006430 NADP+ binding site [chemical binding]; other site 1121335006431 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1121335006432 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1121335006433 dimerization interface [polypeptide binding]; other site 1121335006434 active site 1121335006435 Glucuronate isomerase; Region: UxaC; pfam02614 1121335006436 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1121335006437 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335006438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335006439 DNA binding site [nucleotide binding] 1121335006440 domain linker motif; other site 1121335006441 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335006442 dimerization interface [polypeptide binding]; other site 1121335006443 ligand binding site [chemical binding]; other site 1121335006444 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1121335006445 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1121335006446 NAD binding site [chemical binding]; other site 1121335006447 dimer interface [polypeptide binding]; other site 1121335006448 substrate binding site [chemical binding]; other site 1121335006449 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121335006450 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1121335006451 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1121335006452 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1121335006453 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1121335006454 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1121335006455 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1121335006456 purine monophosphate binding site [chemical binding]; other site 1121335006457 dimer interface [polypeptide binding]; other site 1121335006458 putative catalytic residues [active] 1121335006459 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1121335006460 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1121335006461 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1121335006462 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1121335006463 active site 1121335006464 substrate binding site [chemical binding]; other site 1121335006465 cosubstrate binding site; other site 1121335006466 catalytic site [active] 1121335006467 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1121335006468 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1121335006469 dimerization interface [polypeptide binding]; other site 1121335006470 putative ATP binding site [chemical binding]; other site 1121335006471 AIR carboxylase; Region: AIRC; pfam00731 1121335006472 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1121335006473 6-phosphofructokinase; Provisional; Region: PRK03202 1121335006474 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1121335006475 active site 1121335006476 ADP/pyrophosphate binding site [chemical binding]; other site 1121335006477 dimerization interface [polypeptide binding]; other site 1121335006478 allosteric effector site; other site 1121335006479 fructose-1,6-bisphosphate binding site; other site 1121335006480 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1121335006481 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121335006482 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121335006483 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1121335006484 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1121335006485 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121335006486 HIGH motif; other site 1121335006487 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121335006488 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121335006489 active site 1121335006490 KMSKS motif; other site 1121335006491 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1121335006492 tRNA binding surface [nucleotide binding]; other site 1121335006493 anticodon binding site; other site 1121335006494 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1121335006495 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1121335006496 CotJB protein; Region: CotJB; pfam12652 1121335006497 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121335006498 dinuclear metal binding motif [ion binding]; other site 1121335006499 VanZ like family; Region: VanZ; pfam04892 1121335006500 Transposase; Region: HTH_Tnp_1; pfam01527 1121335006501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1121335006502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121335006503 HTH-like domain; Region: HTH_21; pfam13276 1121335006504 Integrase core domain; Region: rve; pfam00665 1121335006505 Integrase core domain; Region: rve_3; pfam13683 1121335006506 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1121335006507 catalytic residues [active] 1121335006508 catalytic nucleophile [active] 1121335006509 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121335006510 Recombinase; Region: Recombinase; pfam07508 1121335006511 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1121335006512 Mn-containing; COG:3546 Mn-containing catalase; KO:K06334 spore coat protein JC; catalase 1121335006513 enolase; Provisional; Region: eno; PRK00077 1121335006514 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1121335006515 dimer interface [polypeptide binding]; other site 1121335006516 metal binding site [ion binding]; metal-binding site 1121335006517 substrate binding pocket [chemical binding]; other site 1121335006518 hypothetical protein; Provisional; Region: PRK05473 1121335006519 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1121335006520 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121335006521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006522 FeS/SAM binding site; other site 1121335006523 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121335006524 regulatory protein interface [polypeptide binding]; other site 1121335006525 regulatory phosphorylation site [posttranslational modification]; other site 1121335006526 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1121335006527 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1121335006528 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1121335006529 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1121335006530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121335006531 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1121335006532 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1121335006533 Spore germination protein; Region: Spore_permease; cl17796 1121335006534 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335006535 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335006536 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1121335006537 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1121335006538 PCRF domain; Region: PCRF; pfam03462 1121335006539 RF-1 domain; Region: RF-1; pfam00472 1121335006540 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121335006541 Protein of unknown function (DUF970); Region: DUF970; cl17525 1121335006542 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1121335006543 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121335006544 active site 1121335006545 HIGH motif; other site 1121335006546 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121335006547 active site 1121335006548 KMSKS motif; other site 1121335006549 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121335006550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335006551 FeS/SAM binding site; other site 1121335006552 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1121335006553 Family description; Region: UvrD_C_2; pfam13538 1121335006554 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1121335006555 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1121335006556 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121335006557 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1121335006558 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1121335006559 NAD(P) binding site [chemical binding]; other site 1121335006560 catalytic residues [active] 1121335006561 cell division protein FtsZ; Validated; Region: PRK09330 1121335006562 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1121335006563 nucleotide binding site [chemical binding]; other site 1121335006564 SulA interaction site; other site 1121335006565 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1121335006566 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1121335006567 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1121335006568 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121335006569 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121335006570 hinge; other site 1121335006571 active site 1121335006572 cell division protein FtsW; Region: ftsW; TIGR02614 1121335006573 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1121335006574 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1121335006575 Mg++ binding site [ion binding]; other site 1121335006576 putative catalytic motif [active] 1121335006577 putative substrate binding site [chemical binding]; other site 1121335006578 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1121335006579 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121335006580 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335006581 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335006582 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1121335006583 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121335006584 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335006585 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335006586 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1121335006587 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121335006588 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121335006589 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1121335006590 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1121335006591 Cell division protein FtsL; Region: FtsL; cl11433 1121335006592 MraW methylase family; Region: Methyltransf_5; pfam01795 1121335006593 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1121335006594 cell division protein MraZ; Reviewed; Region: PRK00326 1121335006595 MraZ protein; Region: MraZ; pfam02381 1121335006596 MraZ protein; Region: MraZ; pfam02381 1121335006597 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1121335006598 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1121335006599 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121335006600 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1121335006601 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121335006602 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121335006603 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121335006604 Haemolysin-III related; Region: HlyIII; cl03831 1121335006605 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335006606 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335006607 metal binding site [ion binding]; metal-binding site 1121335006608 active site 1121335006609 I-site; other site 1121335006610 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1121335006611 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1121335006612 Predicted periplasmic protein [Function unknown]; Region: COG3698 1121335006613 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 1121335006614 reactive center loop; other site 1121335006615 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 1121335006616 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 1121335006617 catalytic domain interface [polypeptide binding]; other site 1121335006618 putative homodimer interface [polypeptide binding]; other site 1121335006619 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1121335006620 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1121335006621 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335006622 Zn2+ binding site [ion binding]; other site 1121335006623 Mg2+ binding site [ion binding]; other site 1121335006624 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121335006625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335006626 S-adenosylmethionine binding site [chemical binding]; other site 1121335006627 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1121335006628 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1121335006629 homotetramer interface [polypeptide binding]; other site 1121335006630 ligand binding site [chemical binding]; other site 1121335006631 catalytic site [active] 1121335006632 NAD binding site [chemical binding]; other site 1121335006633 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1121335006634 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1121335006635 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1121335006636 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1121335006637 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1121335006638 heterotetramer interface [polypeptide binding]; other site 1121335006639 active site pocket [active] 1121335006640 cleavage site 1121335006641 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121335006642 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121335006643 GAF domain; Region: GAF_3; pfam13492 1121335006644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121335006645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121335006646 metal binding site [ion binding]; metal-binding site 1121335006647 active site 1121335006648 I-site; other site 1121335006649 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1121335006650 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121335006651 minor groove reading motif; other site 1121335006652 helix-hairpin-helix signature motif; other site 1121335006653 substrate binding pocket [chemical binding]; other site 1121335006654 active site 1121335006655 glycogen synthase; Provisional; Region: glgA; PRK00654 1121335006656 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1121335006657 ADP-binding pocket [chemical binding]; other site 1121335006658 homodimer interface [polypeptide binding]; other site 1121335006659 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1121335006660 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1121335006661 RNase E interface [polypeptide binding]; other site 1121335006662 trimer interface [polypeptide binding]; other site 1121335006663 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1121335006664 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1121335006665 RNase E interface [polypeptide binding]; other site 1121335006666 trimer interface [polypeptide binding]; other site 1121335006667 active site 1121335006668 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1121335006669 putative nucleic acid binding region [nucleotide binding]; other site 1121335006670 G-X-X-G motif; other site 1121335006671 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1121335006672 RNA binding site [nucleotide binding]; other site 1121335006673 domain interface; other site 1121335006674 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1121335006675 16S/18S rRNA binding site [nucleotide binding]; other site 1121335006676 S13e-L30e interaction site [polypeptide binding]; other site 1121335006677 25S rRNA binding site [nucleotide binding]; other site 1121335006678 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335006679 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1121335006680 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1121335006681 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1121335006682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335006683 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335006684 COG:0395 ABC-type sugar transport system permease component; contains signal peptide; contains transmembrane domain; ABC transporter permease subunit 1121335006685 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335006686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006687 dimer interface [polypeptide binding]; other site 1121335006688 conserved gate region; other site 1121335006689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335006690 ABC-ATPase subunit interface; other site 1121335006691 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335006692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006693 PBP superfamily domain; Region: PBP_like_2; cl17296 1121335006694 PBP superfamily domain; Region: PBP_like_2; cl17296 1121335006695 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1121335006696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006697 dimer interface [polypeptide binding]; other site 1121335006698 conserved gate region; other site 1121335006699 putative PBP binding loops; other site 1121335006700 ABC-ATPase subunit interface; other site 1121335006701 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121335006702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006703 dimer interface [polypeptide binding]; other site 1121335006704 conserved gate region; other site 1121335006705 putative PBP binding loops; other site 1121335006706 ABC-ATPase subunit interface; other site 1121335006707 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1121335006708 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121335006709 Walker A/P-loop; other site 1121335006710 ATP binding site [chemical binding]; other site 1121335006711 Q-loop/lid; other site 1121335006712 ABC transporter signature motif; other site 1121335006713 Walker B; other site 1121335006714 D-loop; other site 1121335006715 H-loop/switch region; other site 1121335006716 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121335006717 PhoU domain; Region: PhoU; pfam01895 1121335006718 PhoU domain; Region: PhoU; pfam01895 1121335006719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335006721 active site 1121335006722 phosphorylation site [posttranslational modification] 1121335006723 intermolecular recognition site; other site 1121335006724 dimerization interface [polypeptide binding]; other site 1121335006725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335006726 DNA binding site [nucleotide binding] 1121335006727 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121335006728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121335006729 putative active site [active] 1121335006730 heme pocket [chemical binding]; other site 1121335006731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335006732 dimer interface [polypeptide binding]; other site 1121335006733 phosphorylation site [posttranslational modification] 1121335006734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335006735 ATP binding site [chemical binding]; other site 1121335006736 Mg2+ binding site [ion binding]; other site 1121335006737 G-X-G motif; other site 1121335006738 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1121335006739 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1121335006740 dimer interface [polypeptide binding]; other site 1121335006741 active site 1121335006742 metal binding site [ion binding]; metal-binding site 1121335006743 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1121335006744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335006745 active site 1121335006746 catalytic tetrad [active] 1121335006747 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121335006748 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121335006749 Walker A/P-loop; other site 1121335006750 ATP binding site [chemical binding]; other site 1121335006751 Q-loop/lid; other site 1121335006752 ABC transporter signature motif; other site 1121335006753 Walker B; other site 1121335006754 D-loop; other site 1121335006755 H-loop/switch region; other site 1121335006756 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121335006757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335006758 ABC-ATPase subunit interface; other site 1121335006759 dimer interface [polypeptide binding]; other site 1121335006760 putative PBP binding regions; other site 1121335006761 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1121335006762 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1121335006763 putative binding site residues; other site 1121335006764 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1121335006765 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1121335006766 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1121335006767 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1121335006768 recombinase A; Provisional; Region: recA; PRK09354 1121335006769 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1121335006770 hexamer interface [polypeptide binding]; other site 1121335006771 Walker A motif; other site 1121335006772 ATP binding site [chemical binding]; other site 1121335006773 Walker B motif; other site 1121335006774 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335006775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006776 dimer interface [polypeptide binding]; other site 1121335006777 conserved gate region; other site 1121335006778 putative PBP binding loops; other site 1121335006779 ABC-ATPase subunit interface; other site 1121335006780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1121335006781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006782 dimer interface [polypeptide binding]; other site 1121335006783 conserved gate region; other site 1121335006784 putative PBP binding loops; other site 1121335006785 ABC-ATPase subunit interface; other site 1121335006786 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335006787 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335006788 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335006789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335006790 active site 1121335006791 phosphorylation site [posttranslational modification] 1121335006792 intermolecular recognition site; other site 1121335006793 dimerization interface [polypeptide binding]; other site 1121335006794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006795 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335006796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335006797 dimerization interface [polypeptide binding]; other site 1121335006798 Histidine kinase; Region: His_kinase; pfam06580 1121335006799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335006800 ATP binding site [chemical binding]; other site 1121335006801 Mg2+ binding site [ion binding]; other site 1121335006802 G-X-G motif; other site 1121335006803 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1121335006804 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1121335006805 competence damage-inducible protein A; Provisional; Region: PRK00549 1121335006806 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1121335006807 putative MPT binding site; other site 1121335006808 Competence-damaged protein; Region: CinA; pfam02464 1121335006809 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1121335006810 G1 box; other site 1121335006811 GTP/Mg2+ binding site [chemical binding]; other site 1121335006812 Switch I region; other site 1121335006813 G2 box; other site 1121335006814 G3 box; other site 1121335006815 Switch II region; other site 1121335006816 G4 box; other site 1121335006817 G5 box; other site 1121335006818 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1121335006819 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121335006820 Walker A/P-loop; other site 1121335006821 ATP binding site [chemical binding]; other site 1121335006822 Q-loop/lid; other site 1121335006823 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121335006824 ABC transporter signature motif; other site 1121335006825 Walker B; other site 1121335006826 D-loop; other site 1121335006827 H-loop/switch region; other site 1121335006828 arginine repressor; Provisional; Region: argR; PRK00441 1121335006829 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1121335006830 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1121335006831 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1121335006832 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1121335006833 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1121335006834 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335006835 RNA binding surface [nucleotide binding]; other site 1121335006836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335006837 S-adenosylmethionine binding site [chemical binding]; other site 1121335006838 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1121335006839 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1121335006840 TPP-binding site; other site 1121335006841 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121335006842 PYR/PP interface [polypeptide binding]; other site 1121335006843 dimer interface [polypeptide binding]; other site 1121335006844 TPP binding site [chemical binding]; other site 1121335006845 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335006846 Divergent PAP2 family; Region: DUF212; pfam02681 1121335006847 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121335006848 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121335006849 substrate binding pocket [chemical binding]; other site 1121335006850 chain length determination region; other site 1121335006851 substrate-Mg2+ binding site; other site 1121335006852 catalytic residues [active] 1121335006853 aspartate-rich region 1; other site 1121335006854 active site lid residues [active] 1121335006855 aspartate-rich region 2; other site 1121335006856 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1121335006857 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1121335006858 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1121335006859 generic binding surface II; other site 1121335006860 generic binding surface I; other site 1121335006861 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1121335006862 putative RNA binding site [nucleotide binding]; other site 1121335006863 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335006864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335006865 DNA binding site [nucleotide binding] 1121335006866 domain linker motif; other site 1121335006867 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335006868 dimerization interface [polypeptide binding]; other site 1121335006869 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121335006870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335006871 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335006872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006873 dimer interface [polypeptide binding]; other site 1121335006874 conserved gate region; other site 1121335006875 putative PBP binding loops; other site 1121335006876 ABC-ATPase subunit interface; other site 1121335006877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335006878 dimer interface [polypeptide binding]; other site 1121335006879 conserved gate region; other site 1121335006880 putative PBP binding loops; other site 1121335006881 ABC-ATPase subunit interface; other site 1121335006882 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335006883 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335006884 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1121335006885 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1121335006886 active site 1121335006887 catalytic site [active] 1121335006888 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1121335006889 active site 1121335006890 Putative esterase; Region: Esterase; pfam00756 1121335006891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1121335006892 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1121335006893 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1121335006894 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1121335006895 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1121335006896 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1121335006897 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1121335006898 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121335006899 ligand binding site [chemical binding]; other site 1121335006900 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121335006901 flagellar motor protein MotP; Reviewed; Region: PRK06926 1121335006902 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1121335006903 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121335006904 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121335006905 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121335006906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335006907 Coenzyme A binding pocket [chemical binding]; other site 1121335006908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335006909 Zn2+ binding site [ion binding]; other site 1121335006910 Mg2+ binding site [ion binding]; other site 1121335006911 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121335006912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335006913 Zn2+ binding site [ion binding]; other site 1121335006914 Mg2+ binding site [ion binding]; other site 1121335006915 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1121335006916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006917 TPR motif; other site 1121335006918 binding surface 1121335006919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006920 TPR motif; other site 1121335006921 binding surface 1121335006922 TPR repeat; Region: TPR_11; pfam13414 1121335006923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006924 binding surface 1121335006925 TPR motif; other site 1121335006926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335006927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335006928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335006929 binding surface 1121335006930 TPR motif; other site 1121335006931 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335006932 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121335006933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006935 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1121335006936 catalytic core [active] 1121335006937 YcxB-like protein; Region: YcxB; pfam14317 1121335006938 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121335006939 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121335006940 synthetase active site [active] 1121335006941 NTP binding site [chemical binding]; other site 1121335006942 metal binding site [ion binding]; metal-binding site 1121335006943 hypothetical protein; Reviewed; Region: PRK09588 1121335006944 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1121335006945 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1121335006946 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121335006947 PYR/PP interface [polypeptide binding]; other site 1121335006948 dimer interface [polypeptide binding]; other site 1121335006949 TPP binding site [chemical binding]; other site 1121335006950 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121335006951 transketolase; Reviewed; Region: PRK05899 1121335006952 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121335006953 TPP-binding site [chemical binding]; other site 1121335006954 dimer interface [polypeptide binding]; other site 1121335006955 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1121335006956 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1121335006957 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1121335006958 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1121335006959 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1121335006960 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1121335006961 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1121335006962 NAD binding site [chemical binding]; other site 1121335006963 homodimer interface [polypeptide binding]; other site 1121335006964 active site 1121335006965 substrate binding site [chemical binding]; other site 1121335006966 galactokinase; Provisional; Region: PRK05322 1121335006967 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1121335006968 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1121335006969 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1121335006970 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1121335006971 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1121335006972 dimer interface [polypeptide binding]; other site 1121335006973 active site 1121335006974 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335006975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335006977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335006978 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121335006979 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121335006980 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121335006981 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1121335006982 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1121335006983 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121335006984 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121335006985 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335006986 Walker A/P-loop; other site 1121335006987 ATP binding site [chemical binding]; other site 1121335006988 Q-loop/lid; other site 1121335006989 ABC transporter signature motif; other site 1121335006990 Walker B; other site 1121335006991 D-loop; other site 1121335006992 H-loop/switch region; other site 1121335006993 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1121335006994 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121335006995 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335006996 Walker A/P-loop; other site 1121335006997 ATP binding site [chemical binding]; other site 1121335006998 Q-loop/lid; other site 1121335006999 ABC transporter signature motif; other site 1121335007000 Walker B; other site 1121335007001 D-loop; other site 1121335007002 H-loop/switch region; other site 1121335007003 hypothetical protein; Provisional; Region: PRK13661 1121335007004 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1121335007005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335007006 S-adenosylmethionine binding site [chemical binding]; other site 1121335007007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1121335007008 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1121335007009 G5 domain; Region: G5; pfam07501 1121335007010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1121335007011 COG:1196 Chromosome segregation ATPases; contains signal peptide; contains transmembrane domain; hypothetical protein 1121335007012 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1121335007013 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1121335007014 active site 1121335007015 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1121335007016 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1121335007017 HIGH motif; other site 1121335007018 active site 1121335007019 KMSKS motif; other site 1121335007020 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1121335007021 tRNA binding surface [nucleotide binding]; other site 1121335007022 anticodon binding site; other site 1121335007023 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1121335007024 putative tRNA-binding site [nucleotide binding]; other site 1121335007025 dimer interface [polypeptide binding]; other site 1121335007026 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1121335007027 homotrimer interaction site [polypeptide binding]; other site 1121335007028 zinc binding site [ion binding]; other site 1121335007029 CDP-binding sites; other site 1121335007030 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1121335007031 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335007032 Walker A/P-loop; other site 1121335007033 ATP binding site [chemical binding]; other site 1121335007034 Q-loop/lid; other site 1121335007035 ABC transporter signature motif; other site 1121335007036 Walker B; other site 1121335007037 D-loop; other site 1121335007038 H-loop/switch region; other site 1121335007039 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1121335007040 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1121335007041 CoA binding domain; Region: CoA_binding; smart00881 1121335007042 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121335007043 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121335007044 substrate binding site [chemical binding]; other site 1121335007045 glutamase interaction surface [polypeptide binding]; other site 1121335007046 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1121335007047 intersubunit interface [polypeptide binding]; other site 1121335007048 active site 1121335007049 Zn2+ binding site [ion binding]; other site 1121335007050 intersubunit interface [polypeptide binding]; other site 1121335007051 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1121335007052 active site 1121335007053 Zn2+ binding site [ion binding]; other site 1121335007054 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1121335007055 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1121335007056 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121335007057 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121335007058 catalytic residues [active] 1121335007059 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 1121335007060 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1121335007061 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1121335007062 dimerization interface [polypeptide binding]; other site 1121335007063 domain crossover interface; other site 1121335007064 redox-dependent activation switch; other site 1121335007065 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1121335007066 putative active site [active] 1121335007067 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1121335007068 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121335007069 DNA binding site [nucleotide binding] 1121335007070 active site 1121335007071 Protease prsW family; Region: PrsW-protease; pfam13367 1121335007072 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1121335007073 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121335007074 minor groove reading motif; other site 1121335007075 helix-hairpin-helix signature motif; other site 1121335007076 substrate binding pocket [chemical binding]; other site 1121335007077 active site 1121335007078 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 1121335007079 putative FMN binding site [chemical binding]; other site 1121335007080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1121335007081 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1121335007082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335007083 Walker A/P-loop; other site 1121335007084 ATP binding site [chemical binding]; other site 1121335007085 Q-loop/lid; other site 1121335007086 ABC transporter signature motif; other site 1121335007087 Walker B; other site 1121335007088 D-loop; other site 1121335007089 H-loop/switch region; other site 1121335007090 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121335007091 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1121335007092 prephenate dehydrogenase; Validated; Region: PRK06545 1121335007093 prephenate dehydrogenase; Validated; Region: PRK08507 1121335007094 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1121335007095 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121335007096 conserved cys residue [active] 1121335007097 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1121335007098 spermidine synthase; Provisional; Region: PRK00811 1121335007099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335007100 S-adenosylmethionine binding site [chemical binding]; other site 1121335007101 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335007102 metal ion-dependent adhesion site (MIDAS); other site 1121335007103 Protein of unknown function DUF45; Region: DUF45; pfam01863 1121335007104 pyruvate kinase; Provisional; Region: PRK06354 1121335007105 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1121335007106 domain interfaces; other site 1121335007107 active site 1121335007108 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1121335007109 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 1121335007110 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1121335007111 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1121335007112 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1121335007113 active site 1121335007114 RHS Repeat; Region: RHS_repeat; pfam05593 1121335007115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1121335007116 MULE transposase domain; Region: MULE; pfam10551 1121335007117 RHS Repeat; Region: RHS_repeat; pfam05593 1121335007118 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121335007119 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121335007120 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121335007121 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121335007122 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1121335007123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335007124 FeS/SAM binding site; other site 1121335007125 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1121335007126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121335007127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121335007128 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121335007129 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121335007130 ring oligomerisation interface [polypeptide binding]; other site 1121335007131 ATP/Mg binding site [chemical binding]; other site 1121335007132 stacking interactions; other site 1121335007133 hinge regions; other site 1121335007134 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121335007135 oligomerisation interface [polypeptide binding]; other site 1121335007136 mobile loop; other site 1121335007137 roof hairpin; other site 1121335007138 Uncharacterized conserved protein [Function unknown]; Region: COG2454 1121335007139 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1121335007140 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007142 dimer interface [polypeptide binding]; other site 1121335007143 conserved gate region; other site 1121335007144 putative PBP binding loops; other site 1121335007145 ABC-ATPase subunit interface; other site 1121335007146 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335007147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007148 dimer interface [polypeptide binding]; other site 1121335007149 conserved gate region; other site 1121335007150 putative PBP binding loops; other site 1121335007151 ABC-ATPase subunit interface; other site 1121335007152 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335007153 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121335007154 Response regulator receiver domain; Region: Response_reg; pfam00072 1121335007155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335007156 active site 1121335007157 phosphorylation site [posttranslational modification] 1121335007158 intermolecular recognition site; other site 1121335007159 dimerization interface [polypeptide binding]; other site 1121335007160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335007161 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335007162 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1121335007163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335007164 dimerization interface [polypeptide binding]; other site 1121335007165 Histidine kinase; Region: His_kinase; pfam06580 1121335007166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335007167 ATP binding site [chemical binding]; other site 1121335007168 Mg2+ binding site [ion binding]; other site 1121335007169 G-X-G motif; other site 1121335007170 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1121335007171 Part of AAA domain; Region: AAA_19; pfam13245 1121335007172 Family description; Region: UvrD_C_2; pfam13538 1121335007173 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121335007174 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121335007175 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 1121335007176 dimer interface [polypeptide binding]; other site 1121335007177 Citrate synthase; Region: Citrate_synt; pfam00285 1121335007178 active site 1121335007179 citrylCoA binding site [chemical binding]; other site 1121335007180 oxalacetate/citrate binding site [chemical binding]; other site 1121335007181 coenzyme A binding site [chemical binding]; other site 1121335007182 catalytic triad [active] 1121335007183 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1121335007184 Ligand Binding Site [chemical binding]; other site 1121335007185 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1121335007186 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1121335007187 substrate-cofactor binding pocket; other site 1121335007188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335007189 catalytic residue [active] 1121335007190 short chain dehydrogenase; Validated; Region: PRK06182 1121335007191 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1121335007192 NADP binding site [chemical binding]; other site 1121335007193 active site 1121335007194 steroid binding site; other site 1121335007195 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1121335007196 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1121335007197 NodB motif; other site 1121335007198 active site 1121335007199 catalytic site [active] 1121335007200 metal binding site [ion binding]; metal-binding site 1121335007201 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121335007202 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335007203 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335007204 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121335007205 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121335007206 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121335007207 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121335007208 IMP binding site; other site 1121335007209 dimer interface [polypeptide binding]; other site 1121335007210 interdomain contacts; other site 1121335007211 partial ornithine binding site; other site 1121335007212 amidophosphoribosyltransferase; Region: purF; TIGR01134 1121335007213 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1121335007214 active site 1121335007215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007216 active site 1121335007217 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1121335007218 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1121335007219 metal ion-dependent adhesion site (MIDAS); other site 1121335007220 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121335007221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007222 Walker A motif; other site 1121335007223 ATP binding site [chemical binding]; other site 1121335007224 Walker B motif; other site 1121335007225 arginine finger; other site 1121335007226 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121335007227 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121335007228 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1121335007229 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1121335007230 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121335007231 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121335007232 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1121335007233 phosphopentomutase; Provisional; Region: PRK05362 1121335007234 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1121335007235 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1121335007236 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335007237 putative active site [active] 1121335007238 putative metal binding site [ion binding]; other site 1121335007239 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1121335007240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121335007241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121335007242 catalytic residue [active] 1121335007243 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121335007244 active site 1121335007245 catalytic triad [active] 1121335007246 oxyanion hole [active] 1121335007247 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1121335007248 Fe-S cluster binding site [ion binding]; other site 1121335007249 active site 1121335007250 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1121335007251 transcription termination factor Rho; Provisional; Region: PRK12608 1121335007252 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1121335007253 RNA binding site [nucleotide binding]; other site 1121335007254 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1121335007255 multimer interface [polypeptide binding]; other site 1121335007256 Walker A motif; other site 1121335007257 ATP binding site [chemical binding]; other site 1121335007258 Walker B motif; other site 1121335007259 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1121335007260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007261 Walker A motif; other site 1121335007262 ATP binding site [chemical binding]; other site 1121335007263 Walker B motif; other site 1121335007264 arginine finger; other site 1121335007265 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1121335007266 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335007267 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121335007268 active site 1121335007269 metal binding site [ion binding]; metal-binding site 1121335007270 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1121335007271 hypothetical protein; Validated; Region: PRK00110 1121335007272 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1121335007273 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1121335007274 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1121335007275 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1121335007276 active site 1121335007277 Ap6A binding site [chemical binding]; other site 1121335007278 nudix motif; other site 1121335007279 metal binding site [ion binding]; metal-binding site 1121335007280 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1121335007281 30S subunit binding site; other site 1121335007282 Outer membrane efflux protein; Region: OEP; pfam02321 1121335007283 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1121335007284 Bacterial SH3 domain; Region: SH3_3; pfam08239 1121335007285 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1121335007286 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1121335007287 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1121335007288 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1121335007289 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1121335007290 dimer interface [polypeptide binding]; other site 1121335007291 motif 1; other site 1121335007292 active site 1121335007293 motif 2; other site 1121335007294 motif 3; other site 1121335007295 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1121335007296 anticodon binding site; other site 1121335007297 zinc-binding site [ion binding]; other site 1121335007298 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 1121335007299 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1121335007300 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1121335007301 hypothetical protein; Reviewed; Region: PRK00024 1121335007302 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1121335007303 MPN+ (JAMM) motif; other site 1121335007304 Zinc-binding site [ion binding]; other site 1121335007305 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121335007306 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121335007307 active site 1121335007308 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121335007309 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1121335007310 Cl- selectivity filter; other site 1121335007311 Cl- binding residues [ion binding]; other site 1121335007312 pore gating glutamate residue; other site 1121335007313 dimer interface [polypeptide binding]; other site 1121335007314 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1121335007315 UGMP family protein; Validated; Region: PRK09604 1121335007316 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1121335007317 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1121335007318 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1121335007319 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1121335007320 SpoVA protein; Region: SpoVA; cl04298 1121335007321 stage V sporulation protein AD; Validated; Region: PRK08304 1121335007322 stage V sporulation protein AD; Provisional; Region: PRK12404 1121335007323 SpoVA protein; Region: SpoVA; cl04298 1121335007324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007325 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121335007326 Walker A motif; other site 1121335007327 ATP binding site [chemical binding]; other site 1121335007328 Walker B motif; other site 1121335007329 arginine finger; other site 1121335007330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007331 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121335007332 Walker A motif; other site 1121335007333 ATP binding site [chemical binding]; other site 1121335007334 Walker B motif; other site 1121335007335 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121335007336 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121335007337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121335007338 ATP binding site [chemical binding]; other site 1121335007339 Mg2+ binding site [ion binding]; other site 1121335007340 G-X-G motif; other site 1121335007341 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1121335007342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335007343 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121335007344 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335007345 DNA binding residues [nucleotide binding] 1121335007346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121335007347 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121335007348 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121335007349 anti sigma factor interaction site; other site 1121335007350 regulatory phosphorylation site [posttranslational modification]; other site 1121335007351 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1121335007352 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1121335007353 dimer interface [polypeptide binding]; other site 1121335007354 putative anticodon binding site; other site 1121335007355 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1121335007356 motif 1; other site 1121335007357 active site 1121335007358 motif 2; other site 1121335007359 motif 3; other site 1121335007360 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1121335007361 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1121335007362 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1121335007363 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1121335007364 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1121335007365 GIY-YIG motif/motif A; other site 1121335007366 active site 1121335007367 catalytic site [active] 1121335007368 putative DNA binding site [nucleotide binding]; other site 1121335007369 metal binding site [ion binding]; metal-binding site 1121335007370 UvrB/uvrC motif; Region: UVR; pfam02151 1121335007371 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1121335007372 Helix-hairpin-helix motif; Region: HHH; pfam00633 1121335007373 helix-hairpin-helix signature motif; other site 1121335007374 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121335007375 dimerization domain swap beta strand [polypeptide binding]; other site 1121335007376 regulatory protein interface [polypeptide binding]; other site 1121335007377 active site 1121335007378 regulatory phosphorylation site [posttranslational modification]; other site 1121335007379 Putative zinc-finger; Region: zf-HC2; pfam13490 1121335007380 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1121335007381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335007382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335007383 DNA binding residues [nucleotide binding] 1121335007384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335007385 dimerization interface [polypeptide binding]; other site 1121335007386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335007387 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335007388 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335007389 dimer interface [polypeptide binding]; other site 1121335007390 putative CheW interface [polypeptide binding]; other site 1121335007391 ferredoxin; Validated; Region: PRK07118 1121335007392 Putative Fe-S cluster; Region: FeS; cl17515 1121335007393 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121335007394 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1121335007395 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1121335007396 FMN-binding domain; Region: FMN_bind; cl01081 1121335007397 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1121335007398 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1121335007399 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1121335007400 SLBB domain; Region: SLBB; pfam10531 1121335007401 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335007402 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1121335007403 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1121335007404 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1121335007405 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1121335007406 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1121335007407 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1121335007408 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121335007409 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1121335007410 dimerization interface [polypeptide binding]; other site 1121335007411 active site 1121335007412 metal binding site [ion binding]; metal-binding site 1121335007413 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121335007414 catalytic residues [active] 1121335007415 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121335007416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335007417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121335007418 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1121335007419 catalytic residues [active] 1121335007420 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121335007421 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1121335007422 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121335007423 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121335007424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335007425 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121335007426 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1121335007427 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1121335007428 O-Antigen ligase; Region: Wzy_C; cl04850 1121335007429 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 1121335007430 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121335007431 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1121335007432 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1121335007433 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 1121335007434 V-type ATP synthase subunit B; Provisional; Region: PRK04196 1121335007435 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335007436 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1121335007437 Walker A motif homologous position; other site 1121335007438 Walker B motif; other site 1121335007439 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335007440 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1121335007441 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121335007442 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1121335007443 Walker A motif/ATP binding site; other site 1121335007444 Walker B motif; other site 1121335007445 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121335007446 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 1121335007447 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 1121335007448 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1121335007449 V-type ATP synthase subunit I; Validated; Region: PRK05771 1121335007450 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 1121335007451 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 1121335007452 acetylornithine aminotransferase; Provisional; Region: PRK02627 1121335007453 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121335007454 inhibitor-cofactor binding pocket; inhibition site 1121335007455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335007456 catalytic residue [active] 1121335007457 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1121335007458 metal binding site [ion binding]; metal-binding site 1121335007459 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1121335007460 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1121335007461 MULE transposase domain; Region: MULE; pfam10551 1121335007462 germination protein YpeB; Region: spore_YpeB; TIGR02889 1121335007463 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335007464 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1121335007465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335007466 Walker A/P-loop; other site 1121335007467 ATP binding site [chemical binding]; other site 1121335007468 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1121335007469 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121335007470 active site 1121335007471 metal binding site [ion binding]; metal-binding site 1121335007472 DNA binding site [nucleotide binding] 1121335007473 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1121335007474 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1121335007475 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1121335007476 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1121335007477 active site 1121335007478 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1121335007479 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1121335007480 FAD binding site [chemical binding]; other site 1121335007481 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1121335007482 active site 1121335007483 putative substrate binding region [chemical binding]; other site 1121335007484 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1121335007485 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1121335007486 catalytic residues [active] 1121335007487 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1121335007488 ATP binding site [chemical binding]; other site 1121335007489 active site 1121335007490 substrate binding site [chemical binding]; other site 1121335007491 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1121335007492 putative active site pocket [active] 1121335007493 4-fold oligomerization interface [polypeptide binding]; other site 1121335007494 metal binding residues [ion binding]; metal-binding site 1121335007495 3-fold/trimer interface [polypeptide binding]; other site 1121335007496 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1121335007497 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121335007498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121335007499 homodimer interface [polypeptide binding]; other site 1121335007500 catalytic residue [active] 1121335007501 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1121335007502 histidinol dehydrogenase; Region: hisD; TIGR00069 1121335007503 NAD binding site [chemical binding]; other site 1121335007504 dimerization interface [polypeptide binding]; other site 1121335007505 product binding site; other site 1121335007506 substrate binding site [chemical binding]; other site 1121335007507 zinc binding site [ion binding]; other site 1121335007508 catalytic residues [active] 1121335007509 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1121335007510 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1121335007511 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1121335007512 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121335007513 dimer interface [polypeptide binding]; other site 1121335007514 motif 1; other site 1121335007515 active site 1121335007516 motif 2; other site 1121335007517 motif 3; other site 1121335007518 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1121335007519 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121335007520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121335007521 dimer interface [polypeptide binding]; other site 1121335007522 putative CheW interface [polypeptide binding]; other site 1121335007523 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1121335007524 putative FMN binding site [chemical binding]; other site 1121335007525 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121335007526 CAP-like domain; other site 1121335007527 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 1121335007528 active site 1121335007529 primary dimer interface [polypeptide binding]; other site 1121335007530 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1121335007531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335007532 Mg2+ binding site [ion binding]; other site 1121335007533 G-X-G motif; other site 1121335007534 DNA gyrase B; Region: DNA_gyraseB; pfam00204 1121335007535 ATP binding site [chemical binding]; other site 1121335007536 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1121335007537 active site 1121335007538 putative metal-binding site [ion binding]; other site 1121335007539 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121335007540 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1121335007541 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1121335007542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335007543 Walker A motif; other site 1121335007544 ATP binding site [chemical binding]; other site 1121335007545 Walker B motif; other site 1121335007546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121335007547 Clp protease; Region: CLP_protease; pfam00574 1121335007548 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121335007549 oligomer interface [polypeptide binding]; other site 1121335007550 active site residues [active] 1121335007551 trigger factor; Provisional; Region: tig; PRK01490 1121335007552 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121335007553 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1121335007554 S-layer homology domain; Region: SLH; pfam00395 1121335007555 S-layer homology domain; Region: SLH; pfam00395 1121335007556 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1121335007557 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1121335007558 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1121335007559 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1121335007560 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1121335007561 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1121335007562 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1121335007563 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1121335007564 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1121335007565 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1121335007566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121335007567 ATP binding site [chemical binding]; other site 1121335007568 putative Mg++ binding site [ion binding]; other site 1121335007569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121335007570 nucleotide binding region [chemical binding]; other site 1121335007571 ATP-binding site [chemical binding]; other site 1121335007572 TRCF domain; Region: TRCF; pfam03461 1121335007573 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121335007574 putative active site [active] 1121335007575 catalytic residue [active] 1121335007576 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1121335007577 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121335007578 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007579 active site 1121335007580 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1121335007581 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1121335007582 Substrate binding site; other site 1121335007583 Mg++ binding site; other site 1121335007584 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1121335007585 active site 1121335007586 substrate binding site [chemical binding]; other site 1121335007587 CoA binding site [chemical binding]; other site 1121335007588 SpoVG; Region: SpoVG; cl00915 1121335007589 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1121335007590 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121335007591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121335007592 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121335007593 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1121335007594 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121335007595 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1121335007596 Part of AAA domain; Region: AAA_19; pfam13245 1121335007597 AAA domain; Region: AAA_14; pfam13173 1121335007598 Family description; Region: UvrD_C_2; pfam13538 1121335007599 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1121335007600 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1121335007601 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1121335007602 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1121335007603 PemK-like protein; Region: PemK; pfam02452 1121335007604 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1121335007605 alanine racemase; Reviewed; Region: alr; PRK00053 1121335007606 active site 1121335007607 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121335007608 dimer interface [polypeptide binding]; other site 1121335007609 substrate binding site [chemical binding]; other site 1121335007610 catalytic residues [active] 1121335007611 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1121335007612 putative carbohydrate kinase; Provisional; Region: PRK10565 1121335007613 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1121335007614 putative substrate binding site [chemical binding]; other site 1121335007615 putative ATP binding site [chemical binding]; other site 1121335007616 Rubredoxin [Energy production and conversion]; Region: COG1773 1121335007617 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1121335007618 iron binding site [ion binding]; other site 1121335007619 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1121335007620 peptide binding site [polypeptide binding]; other site 1121335007621 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121335007622 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121335007623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335007624 Walker A/P-loop; other site 1121335007625 ATP binding site [chemical binding]; other site 1121335007626 Q-loop/lid; other site 1121335007627 ABC transporter signature motif; other site 1121335007628 Walker B; other site 1121335007629 D-loop; other site 1121335007630 H-loop/switch region; other site 1121335007631 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335007632 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121335007633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121335007634 Walker A/P-loop; other site 1121335007635 ATP binding site [chemical binding]; other site 1121335007636 Q-loop/lid; other site 1121335007637 ABC transporter signature motif; other site 1121335007638 Walker B; other site 1121335007639 D-loop; other site 1121335007640 H-loop/switch region; other site 1121335007641 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121335007642 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1121335007643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121335007644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007645 dimer interface [polypeptide binding]; other site 1121335007646 conserved gate region; other site 1121335007647 putative PBP binding loops; other site 1121335007648 ABC-ATPase subunit interface; other site 1121335007649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121335007650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007651 dimer interface [polypeptide binding]; other site 1121335007652 conserved gate region; other site 1121335007653 putative PBP binding loops; other site 1121335007654 ABC-ATPase subunit interface; other site 1121335007655 hypothetical protein 1121335007656 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1121335007657 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1121335007658 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1121335007659 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1121335007660 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1121335007661 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121335007662 substrate binding site [chemical binding]; other site 1121335007663 ATP binding site [chemical binding]; other site 1121335007664 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121335007665 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121335007666 Walker A/P-loop; other site 1121335007667 ATP binding site [chemical binding]; other site 1121335007668 Q-loop/lid; other site 1121335007669 ABC transporter signature motif; other site 1121335007670 Walker B; other site 1121335007671 D-loop; other site 1121335007672 H-loop/switch region; other site 1121335007673 hypothetical protein; Provisional; Region: PRK05590 1121335007674 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1121335007675 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1121335007676 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1121335007677 active site 1121335007678 HIGH motif; other site 1121335007679 KMSK motif region; other site 1121335007680 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1121335007681 tRNA binding surface [nucleotide binding]; other site 1121335007682 anticodon binding site; other site 1121335007683 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1121335007684 glutamate racemase; Provisional; Region: PRK00865 1121335007685 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1121335007686 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121335007687 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1121335007688 Sporulation and spore germination; Region: Germane; pfam10646 1121335007689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1121335007690 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1121335007691 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121335007692 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1121335007693 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121335007694 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121335007695 active site 1121335007696 metal binding site [ion binding]; metal-binding site 1121335007697 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1121335007698 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1121335007699 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1121335007700 active site 1121335007701 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1121335007702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121335007703 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1121335007704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1121335007705 active site 1121335007706 catalytic tetrad [active] 1121335007707 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1121335007708 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1121335007709 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121335007710 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1121335007711 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1121335007712 inhibitor binding site; inhibition site 1121335007713 active site 1121335007714 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1121335007715 Helix-turn-helix domain; Region: HTH_38; pfam13936 1121335007716 Integrase core domain; Region: rve; pfam00665 1121335007717 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1121335007718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335007719 FeS/SAM binding site; other site 1121335007720 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121335007721 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121335007722 putative dimer interface [polypeptide binding]; other site 1121335007723 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1121335007724 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1121335007725 active site 1121335007726 homodimer interface [polypeptide binding]; other site 1121335007727 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1121335007728 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1121335007729 Mg++ binding site [ion binding]; other site 1121335007730 putative catalytic motif [active] 1121335007731 substrate binding site [chemical binding]; other site 1121335007732 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1121335007733 catalytic motif [active] 1121335007734 Zn binding site [ion binding]; other site 1121335007735 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007736 active site 1121335007737 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1121335007738 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1121335007739 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1121335007740 active site 1121335007741 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1121335007742 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1121335007743 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335007744 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335007745 Walker A/P-loop; other site 1121335007746 ATP binding site [chemical binding]; other site 1121335007747 Q-loop/lid; other site 1121335007748 ABC transporter signature motif; other site 1121335007749 Walker B; other site 1121335007750 D-loop; other site 1121335007751 H-loop/switch region; other site 1121335007752 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335007753 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1121335007754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335007755 putative DNA binding site [nucleotide binding]; other site 1121335007756 putative Zn2+ binding site [ion binding]; other site 1121335007757 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1121335007758 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1121335007759 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1121335007760 putative ligand binding site [chemical binding]; other site 1121335007761 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121335007762 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121335007763 Walker A/P-loop; other site 1121335007764 ATP binding site [chemical binding]; other site 1121335007765 Q-loop/lid; other site 1121335007766 ABC transporter signature motif; other site 1121335007767 Walker B; other site 1121335007768 D-loop; other site 1121335007769 H-loop/switch region; other site 1121335007770 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121335007771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335007772 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335007773 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1121335007774 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121335007775 TM-ABC transporter signature motif; other site 1121335007776 gamma-glutamyl kinase; Provisional; Region: PRK05429 1121335007777 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1121335007778 nucleotide binding site [chemical binding]; other site 1121335007779 homotetrameric interface [polypeptide binding]; other site 1121335007780 putative phosphate binding site [ion binding]; other site 1121335007781 putative allosteric binding site; other site 1121335007782 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121335007783 IHF dimer interface [polypeptide binding]; other site 1121335007784 IHF - DNA interface [nucleotide binding]; other site 1121335007785 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1121335007786 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1121335007787 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 1121335007788 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1121335007789 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1121335007790 FlaG protein; Region: FlaG; pfam03646 1121335007791 flagellin; Reviewed; Region: PRK08869 1121335007792 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121335007793 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121335007794 carbon storage regulator; Provisional; Region: PRK01712 1121335007795 flagellar assembly protein FliW; Provisional; Region: PRK13285 1121335007796 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1121335007797 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121335007798 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121335007799 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1121335007800 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335007801 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 1121335007802 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121335007803 metal ion-dependent adhesion site (MIDAS); other site 1121335007804 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121335007805 FlgN protein; Region: FlgN; pfam05130 1121335007806 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1121335007807 flagellar operon protein TIGR03826; Region: YvyF 1121335007808 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121335007809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335007810 active site 1121335007811 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1121335007812 AAA domain; Region: AAA_30; pfam13604 1121335007813 Family description; Region: UvrD_C_2; pfam13538 1121335007814 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1121335007815 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121335007816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121335007817 Zn2+ binding site [ion binding]; other site 1121335007818 Mg2+ binding site [ion binding]; other site 1121335007819 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121335007820 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121335007821 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121335007822 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121335007823 Rubredoxin [Energy production and conversion]; Region: COG1773 1121335007824 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1121335007825 iron binding site [ion binding]; other site 1121335007826 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1121335007827 PAS domain; Region: PAS_9; pfam13426 1121335007828 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121335007829 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121335007830 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121335007831 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121335007832 substrate binding pocket [chemical binding]; other site 1121335007833 chain length determination region; other site 1121335007834 substrate-Mg2+ binding site; other site 1121335007835 catalytic residues [active] 1121335007836 aspartate-rich region 1; other site 1121335007837 active site lid residues [active] 1121335007838 aspartate-rich region 2; other site 1121335007839 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1121335007840 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1121335007841 TQO small subunit DoxD; Region: DoxD; pfam04173 1121335007842 Predicted integral membrane protein [Function unknown]; Region: COG5652 1121335007843 ferric uptake regulator; Provisional; Region: fur; PRK09462 1121335007844 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121335007845 metal binding site 2 [ion binding]; metal-binding site 1121335007846 putative DNA binding helix; other site 1121335007847 metal binding site 1 [ion binding]; metal-binding site 1121335007848 dimer interface [polypeptide binding]; other site 1121335007849 structural Zn2+ binding site [ion binding]; other site 1121335007850 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121335007851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121335007852 ABC-ATPase subunit interface; other site 1121335007853 dimer interface [polypeptide binding]; other site 1121335007854 putative PBP binding regions; other site 1121335007855 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121335007856 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1121335007857 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1121335007858 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121335007859 metal binding site [ion binding]; metal-binding site 1121335007860 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1121335007861 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1121335007862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335007863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121335007864 DNA binding residues [nucleotide binding] 1121335007865 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121335007866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121335007867 S-adenosylmethionine binding site [chemical binding]; other site 1121335007868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335007869 binding surface 1121335007870 TPR motif; other site 1121335007871 TPR repeat; Region: TPR_11; pfam13414 1121335007872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335007873 binding surface 1121335007874 TPR motif; other site 1121335007875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121335007876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121335007877 binding surface 1121335007878 TPR motif; other site 1121335007879 TPR repeat; Region: TPR_11; pfam13414 1121335007880 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1121335007881 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 1121335007882 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335007883 Walker A/P-loop; other site 1121335007884 ATP binding site [chemical binding]; other site 1121335007885 Q-loop/lid; other site 1121335007886 ABC transporter signature motif; other site 1121335007887 Walker B; other site 1121335007888 D-loop; other site 1121335007889 H-loop/switch region; other site 1121335007890 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 1121335007891 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121335007892 Walker A/P-loop; other site 1121335007893 ATP binding site [chemical binding]; other site 1121335007894 Q-loop/lid; other site 1121335007895 ABC transporter signature motif; other site 1121335007896 Walker B; other site 1121335007897 D-loop; other site 1121335007898 H-loop/switch region; other site 1121335007899 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1121335007900 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1121335007901 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1121335007902 alphaNTD - beta interaction site [polypeptide binding]; other site 1121335007903 alphaNTD homodimer interface [polypeptide binding]; other site 1121335007904 alphaNTD - beta' interaction site [polypeptide binding]; other site 1121335007905 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1121335007906 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1121335007907 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1121335007908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121335007909 RNA binding surface [nucleotide binding]; other site 1121335007910 30S ribosomal protein S11; Validated; Region: PRK05309 1121335007911 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1121335007912 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1121335007913 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1121335007914 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1121335007915 rRNA binding site [nucleotide binding]; other site 1121335007916 predicted 30S ribosome binding site; other site 1121335007917 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1121335007918 RNA binding site [nucleotide binding]; other site 1121335007919 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121335007920 active site 1121335007921 adenylate kinase; Reviewed; Region: adk; PRK00279 1121335007922 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1121335007923 AMP-binding site [chemical binding]; other site 1121335007924 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1121335007925 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1121335007926 SecY translocase; Region: SecY; pfam00344 1121335007927 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1121335007928 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1121335007929 23S rRNA binding site [nucleotide binding]; other site 1121335007930 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1121335007931 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1121335007932 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1121335007933 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1121335007934 5S rRNA interface [nucleotide binding]; other site 1121335007935 23S rRNA interface [nucleotide binding]; other site 1121335007936 L5 interface [polypeptide binding]; other site 1121335007937 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1121335007938 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121335007939 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121335007940 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1121335007941 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1121335007942 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1121335007943 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1121335007944 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1121335007945 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1121335007946 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1121335007947 RNA binding site [nucleotide binding]; other site 1121335007948 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1121335007949 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1121335007950 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1121335007951 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1121335007952 23S rRNA interface [nucleotide binding]; other site 1121335007953 putative translocon interaction site; other site 1121335007954 signal recognition particle (SRP54) interaction site; other site 1121335007955 L23 interface [polypeptide binding]; other site 1121335007956 trigger factor interaction site; other site 1121335007957 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1121335007958 23S rRNA interface [nucleotide binding]; other site 1121335007959 5S rRNA interface [nucleotide binding]; other site 1121335007960 putative antibiotic binding site [chemical binding]; other site 1121335007961 L25 interface [polypeptide binding]; other site 1121335007962 L27 interface [polypeptide binding]; other site 1121335007963 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1121335007964 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1121335007965 G-X-X-G motif; other site 1121335007966 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1121335007967 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1121335007968 putative translocon binding site; other site 1121335007969 protein-rRNA interface [nucleotide binding]; other site 1121335007970 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1121335007971 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1121335007972 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1121335007973 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1121335007974 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1121335007975 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1121335007976 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1121335007977 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1121335007978 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1121335007979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121335007980 Coenzyme A binding pocket [chemical binding]; other site 1121335007981 Glycoprotease family; Region: Peptidase_M22; pfam00814 1121335007982 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1121335007983 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1121335007984 Pectinesterase; Region: Pectinesterase; pfam01095 1121335007985 putative pectinesterase; Region: PLN02432; cl01911 1121335007986 Holin family; Region: Phage_holin_4; cl01989 1121335007987 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335007988 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335007989 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1121335007990 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335007991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007992 dimer interface [polypeptide binding]; other site 1121335007993 conserved gate region; other site 1121335007994 ABC-ATPase subunit interface; other site 1121335007995 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335007996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335007997 dimer interface [polypeptide binding]; other site 1121335007998 conserved gate region; other site 1121335007999 ABC-ATPase subunit interface; other site 1121335008000 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1121335008001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335008002 active site 1121335008003 phosphorylation site [posttranslational modification] 1121335008004 intermolecular recognition site; other site 1121335008005 dimerization interface [polypeptide binding]; other site 1121335008006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121335008009 HAMP domain; Region: HAMP; pfam00672 1121335008010 dimerization interface [polypeptide binding]; other site 1121335008011 Histidine kinase; Region: His_kinase; pfam06580 1121335008012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335008013 ATP binding site [chemical binding]; other site 1121335008014 Mg2+ binding site [ion binding]; other site 1121335008015 G-X-G motif; other site 1121335008016 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335008017 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121335008018 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 1121335008019 4Fe-4S binding domain; Region: Fer4; pfam00037 1121335008020 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1121335008021 Rubrerythrin [Energy production and conversion]; Region: COG1592 1121335008022 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1121335008023 binuclear metal center [ion binding]; other site 1121335008024 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1121335008025 iron binding site [ion binding]; other site 1121335008026 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1121335008027 active site 1121335008028 catalytic triad [active] 1121335008029 oxyanion hole [active] 1121335008030 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1121335008031 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1121335008032 active site 1121335008033 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1121335008034 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1121335008035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335008036 Walker A motif; other site 1121335008037 ATP binding site [chemical binding]; other site 1121335008038 Walker B motif; other site 1121335008039 arginine finger; other site 1121335008040 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121335008041 elongation factor Tu; Reviewed; Region: PRK00049 1121335008042 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1121335008043 G1 box; other site 1121335008044 GEF interaction site [polypeptide binding]; other site 1121335008045 GTP/Mg2+ binding site [chemical binding]; other site 1121335008046 Switch I region; other site 1121335008047 G2 box; other site 1121335008048 G3 box; other site 1121335008049 Switch II region; other site 1121335008050 G4 box; other site 1121335008051 G5 box; other site 1121335008052 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1121335008053 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1121335008054 Antibiotic Binding Site [chemical binding]; other site 1121335008055 elongation factor G; Reviewed; Region: PRK00007 1121335008056 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121335008057 G1 box; other site 1121335008058 putative GEF interaction site [polypeptide binding]; other site 1121335008059 GTP/Mg2+ binding site [chemical binding]; other site 1121335008060 Switch I region; other site 1121335008061 G2 box; other site 1121335008062 G3 box; other site 1121335008063 Switch II region; other site 1121335008064 G4 box; other site 1121335008065 G5 box; other site 1121335008066 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121335008067 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121335008068 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121335008069 30S ribosomal protein S7; Validated; Region: PRK05302 1121335008070 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1121335008071 S17 interaction site [polypeptide binding]; other site 1121335008072 S8 interaction site; other site 1121335008073 16S rRNA interaction site [nucleotide binding]; other site 1121335008074 streptomycin interaction site [chemical binding]; other site 1121335008075 23S rRNA interaction site [nucleotide binding]; other site 1121335008076 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1121335008077 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1121335008078 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121335008079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335008080 Walker A/P-loop; other site 1121335008081 ATP binding site [chemical binding]; other site 1121335008082 Q-loop/lid; other site 1121335008083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121335008084 ABC transporter; Region: ABC_tran_2; pfam12848 1121335008085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121335008086 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121335008087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008088 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335008089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008090 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121335008091 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121335008092 ring oligomerisation interface [polypeptide binding]; other site 1121335008093 ATP/Mg binding site [chemical binding]; other site 1121335008094 stacking interactions; other site 1121335008095 hinge regions; other site 1121335008096 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121335008097 oligomerisation interface [polypeptide binding]; other site 1121335008098 mobile loop; other site 1121335008099 roof hairpin; other site 1121335008100 pantothenate kinase; Reviewed; Region: PRK13318 1121335008101 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 1121335008102 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1121335008103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121335008104 putative DNA binding site [nucleotide binding]; other site 1121335008105 putative Zn2+ binding site [ion binding]; other site 1121335008106 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1121335008107 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1121335008108 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 1121335008109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121335008110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335008111 active site 1121335008112 phosphorylation site [posttranslational modification] 1121335008113 intermolecular recognition site; other site 1121335008114 dimerization interface [polypeptide binding]; other site 1121335008115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121335008116 DNA binding residues [nucleotide binding] 1121335008117 dimerization interface [polypeptide binding]; other site 1121335008118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1121335008119 Histidine kinase; Region: HisKA_3; pfam07730 1121335008120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335008121 ATP binding site [chemical binding]; other site 1121335008122 Mg2+ binding site [ion binding]; other site 1121335008123 G-X-G motif; other site 1121335008124 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121335008125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335008126 motif II; other site 1121335008127 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1121335008128 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121335008129 ligand binding site [chemical binding]; other site 1121335008130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121335008131 TPR motif; other site 1121335008132 binding surface 1121335008133 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1121335008134 peptidase T-like protein; Region: PepT-like; TIGR01883 1121335008135 metal binding site [ion binding]; metal-binding site 1121335008136 putative dimer interface [polypeptide binding]; other site 1121335008137 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121335008138 trimer interface [polypeptide binding]; other site 1121335008139 active site 1121335008140 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121335008141 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121335008142 Collagenase; Region: DUF3656; pfam12392 1121335008143 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121335008144 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1121335008145 Cell division protein ZapA; Region: ZapA; pfam05164 1121335008146 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1121335008147 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1121335008148 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1121335008149 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1121335008150 RNA binding site [nucleotide binding]; other site 1121335008151 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1121335008152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121335008153 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1121335008154 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1121335008155 Asp23 family; Region: Asp23; cl00574 1121335008156 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1121335008157 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1121335008158 Walker A/P-loop; other site 1121335008159 ATP binding site [chemical binding]; other site 1121335008160 Q-loop/lid; other site 1121335008161 ABC transporter signature motif; other site 1121335008162 Walker B; other site 1121335008163 D-loop; other site 1121335008164 H-loop/switch region; other site 1121335008165 TOBE domain; Region: TOBE; pfam03459 1121335008166 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1121335008167 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121335008168 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1121335008169 feedback inhibition sensing region; other site 1121335008170 homohexameric interface [polypeptide binding]; other site 1121335008171 nucleotide binding site [chemical binding]; other site 1121335008172 N-acetyl-L-glutamate binding site [chemical binding]; other site 1121335008173 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1121335008174 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1121335008175 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1121335008176 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1121335008177 substrate binding pocket [chemical binding]; other site 1121335008178 dimer interface [polypeptide binding]; other site 1121335008179 inhibitor binding site; inhibition site 1121335008180 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1121335008181 B12 binding site [chemical binding]; other site 1121335008182 cobalt ligand [ion binding]; other site 1121335008183 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1121335008184 FtsH Extracellular; Region: FtsH_ext; pfam06480 1121335008185 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1121335008186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121335008187 Walker A motif; other site 1121335008188 ATP binding site [chemical binding]; other site 1121335008189 Walker B motif; other site 1121335008190 arginine finger; other site 1121335008191 Peptidase family M41; Region: Peptidase_M41; pfam01434 1121335008192 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1121335008193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121335008194 active site 1121335008195 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1121335008196 Ligand Binding Site [chemical binding]; other site 1121335008197 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121335008198 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1121335008199 replicative DNA helicase; Region: DnaB; TIGR00665 1121335008200 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121335008201 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1121335008202 Walker A motif; other site 1121335008203 ATP binding site [chemical binding]; other site 1121335008204 Walker B motif; other site 1121335008205 DNA binding loops [nucleotide binding] 1121335008206 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1121335008207 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1121335008208 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1121335008209 MazG-like family; Region: MazG-like; pfam12643 1121335008210 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1121335008211 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1121335008212 Ligand Binding Site [chemical binding]; other site 1121335008213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335008214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008215 dimer interface [polypeptide binding]; other site 1121335008216 ABC-ATPase subunit interface; other site 1121335008217 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335008218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008219 dimer interface [polypeptide binding]; other site 1121335008220 conserved gate region; other site 1121335008221 ABC-ATPase subunit interface; other site 1121335008222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335008223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121335008224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121335008225 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1121335008226 FOG: CBS domain [General function prediction only]; Region: COG0517 1121335008227 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1121335008228 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1121335008229 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1121335008230 dimerization interface [polypeptide binding]; other site 1121335008231 active site 1121335008232 L-aspartate oxidase; Provisional; Region: PRK06175 1121335008233 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1121335008234 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121335008235 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 1121335008236 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1121335008237 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1121335008238 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1121335008239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1121335008240 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1121335008241 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121335008242 glycerol kinase; Provisional; Region: glpK; PRK00047 1121335008243 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1121335008244 N- and C-terminal domain interface [polypeptide binding]; other site 1121335008245 active site 1121335008246 MgATP binding site [chemical binding]; other site 1121335008247 catalytic site [active] 1121335008248 metal binding site [ion binding]; metal-binding site 1121335008249 glycerol binding site [chemical binding]; other site 1121335008250 homotetramer interface [polypeptide binding]; other site 1121335008251 homodimer interface [polypeptide binding]; other site 1121335008252 FBP binding site [chemical binding]; other site 1121335008253 protein IIAGlc interface [polypeptide binding]; other site 1121335008254 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1121335008255 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1121335008256 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1121335008257 putative NAD(P) binding site [chemical binding]; other site 1121335008258 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1121335008259 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1121335008260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121335008261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121335008262 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121335008263 Walker A/P-loop; other site 1121335008264 ATP binding site [chemical binding]; other site 1121335008265 Q-loop/lid; other site 1121335008266 ABC transporter signature motif; other site 1121335008267 Walker B; other site 1121335008268 D-loop; other site 1121335008269 H-loop/switch region; other site 1121335008270 radical SAM peptide maturase, GG-Bacteroidales family; Region: GG_samocin_CFB; TIGR04148 1121335008271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121335008272 FeS/SAM binding site; other site 1121335008273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121335008274 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121335008275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008276 ABC-ATPase subunit interface; other site 1121335008277 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1121335008278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008279 dimer interface [polypeptide binding]; other site 1121335008280 conserved gate region; other site 1121335008281 ABC-ATPase subunit interface; other site 1121335008282 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335008283 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335008284 Walker A/P-loop; other site 1121335008285 ATP binding site [chemical binding]; other site 1121335008286 Q-loop/lid; other site 1121335008287 ABC transporter signature motif; other site 1121335008288 Walker B; other site 1121335008289 D-loop; other site 1121335008290 H-loop/switch region; other site 1121335008291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335008292 FtsX-like permease family; Region: FtsX; pfam02687 1121335008293 FtsX-like permease family; Region: FtsX; pfam02687 1121335008294 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 1121335008295 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1121335008296 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1121335008297 active site 1121335008298 dimer interface [polypeptide binding]; other site 1121335008299 effector binding site; other site 1121335008300 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1121335008301 TSCPD domain; Region: TSCPD; pfam12637 1121335008302 hypothetical protein; Provisional; Region: PRK04164 1121335008303 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1121335008304 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1121335008305 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1121335008306 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1121335008307 HflX GTPase family; Region: HflX; cd01878 1121335008308 G1 box; other site 1121335008309 GTP/Mg2+ binding site [chemical binding]; other site 1121335008310 Switch I region; other site 1121335008311 G2 box; other site 1121335008312 G3 box; other site 1121335008313 Switch II region; other site 1121335008314 G4 box; other site 1121335008315 G5 box; other site 1121335008316 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335008317 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121335008318 FtsX-like permease family; Region: FtsX; pfam02687 1121335008319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335008320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335008321 Walker A/P-loop; other site 1121335008322 ATP binding site [chemical binding]; other site 1121335008323 Q-loop/lid; other site 1121335008324 ABC transporter signature motif; other site 1121335008325 Walker B; other site 1121335008326 D-loop; other site 1121335008327 H-loop/switch region; other site 1121335008328 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121335008329 carboxyltransferase (CT) interaction site; other site 1121335008330 biotinylation site [posttranslational modification]; other site 1121335008331 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121335008332 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1121335008333 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1121335008334 active site 1121335008335 dimer interface [polypeptide binding]; other site 1121335008336 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1121335008337 Amidohydrolase; Region: Amidohydro_2; pfam04909 1121335008338 active site 1121335008339 hypothetical protein; Provisional; Region: PRK02947 1121335008340 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1121335008341 putative active site [active] 1121335008342 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121335008343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1121335008344 motif II; other site 1121335008345 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1121335008346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121335008347 active site 1121335008348 motif I; other site 1121335008349 motif II; other site 1121335008350 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121335008351 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1121335008352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008353 dimer interface [polypeptide binding]; other site 1121335008354 conserved gate region; other site 1121335008355 putative PBP binding loops; other site 1121335008356 ABC-ATPase subunit interface; other site 1121335008357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121335008358 dimer interface [polypeptide binding]; other site 1121335008359 conserved gate region; other site 1121335008360 putative PBP binding loops; other site 1121335008361 ABC-ATPase subunit interface; other site 1121335008362 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1121335008363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121335008364 Walker A/P-loop; other site 1121335008365 ATP binding site [chemical binding]; other site 1121335008366 Q-loop/lid; other site 1121335008367 ABC transporter signature motif; other site 1121335008368 Walker B; other site 1121335008369 D-loop; other site 1121335008370 H-loop/switch region; other site 1121335008371 TOBE domain; Region: TOBE_2; pfam08402 1121335008372 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1121335008373 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121335008374 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121335008375 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1121335008376 active site 1121335008377 trimer interface [polypeptide binding]; other site 1121335008378 allosteric site; other site 1121335008379 active site lid [active] 1121335008380 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1121335008381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1121335008382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1121335008383 DNA binding site [nucleotide binding] 1121335008384 domain linker motif; other site 1121335008385 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1121335008386 ligand binding site [chemical binding]; other site 1121335008387 dimerization interface [polypeptide binding]; other site 1121335008388 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1121335008389 dimerization interface [polypeptide binding]; other site 1121335008390 putative active cleft [active] 1121335008391 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1121335008392 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1121335008393 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121335008394 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121335008395 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121335008396 hinge; other site 1121335008397 active site 1121335008398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1121335008399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121335008400 dimerization interface [polypeptide binding]; other site 1121335008401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121335008402 dimer interface [polypeptide binding]; other site 1121335008403 phosphorylation site [posttranslational modification] 1121335008404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121335008405 ATP binding site [chemical binding]; other site 1121335008406 Mg2+ binding site [ion binding]; other site 1121335008407 G-X-G motif; other site 1121335008408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121335008409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121335008410 active site 1121335008411 phosphorylation site [posttranslational modification] 1121335008412 intermolecular recognition site; other site 1121335008413 dimerization interface [polypeptide binding]; other site 1121335008414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121335008415 DNA binding site [nucleotide binding] 1121335008416 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121335008417 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121335008418 FtsX-like permease family; Region: FtsX; pfam02687 1121335008419 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121335008420 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121335008421 Yip1 domain; Region: Yip1; pfam04893 1121335008422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121335008423 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121335008424 Walker A/P-loop; other site 1121335008425 ATP binding site [chemical binding]; other site 1121335008426 Q-loop/lid; other site 1121335008427 ABC transporter signature motif; other site 1121335008428 Walker B; other site 1121335008429 D-loop; other site 1121335008430 H-loop/switch region; other site 1121335008431 DNA gyrase subunit A; Validated; Region: PRK05560 1121335008432 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121335008433 CAP-like domain; other site 1121335008434 active site 1121335008435 primary dimer interface [polypeptide binding]; other site 1121335008436 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008437 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008438 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008439 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008440 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008441 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121335008442 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1121335008443 ParB-like nuclease domain; Region: ParBc; pfam02195 1121335008444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121335008445 non-specific DNA binding site [nucleotide binding]; other site 1121335008446 salt bridge; other site 1121335008447 sequence-specific DNA binding site [nucleotide binding]; other site 1121335008448 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1121335008449 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1121335008450 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1121335008451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121335008452 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1121335008453 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1121335008454 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1121335008455 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1121335008456 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1121335008457 G1 box; other site 1121335008458 GTP/Mg2+ binding site [chemical binding]; other site 1121335008459 Switch I region; other site 1121335008460 G2 box; other site 1121335008461 Switch II region; other site 1121335008462 G3 box; other site 1121335008463 G4 box; other site 1121335008464 G5 box; other site 1121335008465 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1121335008466 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1121335008467 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1121335008468 G-X-X-G motif; other site 1121335008469 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1121335008470 RxxxH motif; other site 1121335008471 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1121335008472 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1121335008473 Haemolytic domain; Region: Haemolytic; pfam01809 1121335008474 ribonuclease P; Reviewed; Region: rnpA; PRK00499