-- dump date 20140619_045632 -- class Genbank::misc_feature -- table misc_feature_note -- id note 637887000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 637887000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 637887000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887000004 Walker A motif; other site 637887000005 ATP binding site [chemical binding]; other site 637887000006 Walker B motif; other site 637887000007 arginine finger; other site 637887000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 637887000009 DnaA box-binding interface [nucleotide binding]; other site 637887000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 637887000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 637887000012 putative DNA binding surface [nucleotide binding]; other site 637887000013 dimer interface [polypeptide binding]; other site 637887000014 beta-clamp/clamp loader binding surface; other site 637887000015 beta-clamp/translesion DNA polymerase binding surface; other site 637887000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887000017 RNA binding surface [nucleotide binding]; other site 637887000018 recombination protein F; Reviewed; Region: recF; PRK00064 637887000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 637887000020 Walker A/P-loop; other site 637887000021 ATP binding site [chemical binding]; other site 637887000022 Q-loop/lid; other site 637887000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887000024 ABC transporter signature motif; other site 637887000025 Walker B; other site 637887000026 D-loop; other site 637887000027 H-loop/switch region; other site 637887000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 637887000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887000030 ATP binding site [chemical binding]; other site 637887000031 Mg2+ binding site [ion binding]; other site 637887000032 G-X-G motif; other site 637887000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 637887000034 anchoring element; other site 637887000035 dimer interface [polypeptide binding]; other site 637887000036 ATP binding site [chemical binding]; other site 637887000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637887000038 active site 637887000039 putative metal-binding site [ion binding]; other site 637887000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637887000041 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637887000042 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637887000043 P-loop; other site 637887000044 Magnesium ion binding site [ion binding]; other site 637887000045 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 637887000046 ParB-like nuclease domain; Region: ParB; smart00470 637887000047 KorB domain; Region: KorB; pfam08535 637887000048 Tetratricopeptide repeat; Region: TPR_6; pfam13174 637887000049 seryl-tRNA synthetase; Provisional; Region: PRK05431 637887000050 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 637887000051 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 637887000052 dimer interface [polypeptide binding]; other site 637887000053 active site 637887000054 motif 1; other site 637887000055 motif 2; other site 637887000056 motif 3; other site 637887000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637887000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637887000059 putative substrate translocation pore; other site 637887000060 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887000061 S-layer homology domain; Region: SLH; pfam00395 637887000062 S-layer homology domain; Region: SLH; pfam00395 637887000063 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 637887000064 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 637887000065 VanW like protein; Region: VanW; pfam04294 637887000066 G5 domain; Region: G5; pfam07501 637887000067 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887000068 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887000069 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 637887000070 putative active site [active] 637887000071 Zn binding site [ion binding]; other site 637887000072 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 637887000073 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 637887000074 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 637887000075 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 637887000076 4Fe-4S binding domain; Region: Fer4; pfam00037 637887000077 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 637887000078 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637887000079 dimer interface [polypeptide binding]; other site 637887000080 PYR/PP interface [polypeptide binding]; other site 637887000081 TPP binding site [chemical binding]; other site 637887000082 substrate binding site [chemical binding]; other site 637887000083 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 637887000084 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 637887000085 TPP-binding site [chemical binding]; other site 637887000086 putative dimer interface [polypeptide binding]; other site 637887000087 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 637887000088 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637887000089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637887000090 non-specific DNA binding site [nucleotide binding]; other site 637887000091 salt bridge; other site 637887000092 sequence-specific DNA binding site [nucleotide binding]; other site 637887000093 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 637887000094 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 637887000095 spore coat protein YutH; Region: spore_yutH; TIGR02905 637887000096 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 637887000097 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 637887000098 Potassium binding sites [ion binding]; other site 637887000099 Cesium cation binding sites [ion binding]; other site 637887000100 YabG peptidase U57; Region: Peptidase_U57; pfam05582 637887000101 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 637887000102 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 637887000103 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 637887000104 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 637887000105 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637887000106 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887000107 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 637887000108 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637887000109 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637887000110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637887000111 DNA-binding site [nucleotide binding]; DNA binding site 637887000112 FCD domain; Region: FCD; pfam07729 637887000113 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637887000114 metal-binding site [ion binding] 637887000115 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 637887000116 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 637887000117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887000118 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637887000119 Walker A motif; other site 637887000120 ATP binding site [chemical binding]; other site 637887000121 Walker B motif; other site 637887000122 arginine finger; other site 637887000123 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 637887000124 Protein of unknown function (DUF342); Region: DUF342; pfam03961 637887000125 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 637887000126 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637887000127 active site 637887000128 metal binding site [ion binding]; metal-binding site 637887000129 DNA binding site [nucleotide binding] 637887000130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887000131 Walker A/P-loop; other site 637887000132 ATP binding site [chemical binding]; other site 637887000133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887000134 Q-loop/lid; other site 637887000135 ABC transporter signature motif; other site 637887000136 Walker B; other site 637887000137 D-loop; other site 637887000138 H-loop/switch region; other site 637887000139 Bacterial SH3 domain; Region: SH3_4; pfam06347 637887000140 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637887000141 NlpC/P60 family; Region: NLPC_P60; pfam00877 637887000142 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887000143 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 637887000144 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637887000145 germination protein YpeB; Region: spore_YpeB; TIGR02889 637887000146 CAAX protease self-immunity; Region: Abi; pfam02517 637887000147 DNA replication protein DnaC; Validated; Region: PRK06835 637887000148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887000149 Walker A motif; other site 637887000150 ATP binding site [chemical binding]; other site 637887000151 Walker B motif; other site 637887000152 arginine finger; other site 637887000153 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 637887000154 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 637887000155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887000156 Zn2+ binding site [ion binding]; other site 637887000157 Mg2+ binding site [ion binding]; other site 637887000158 Cellulose binding domain; Region: CBM_3; smart01067 637887000159 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 637887000160 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887000161 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 637887000162 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 637887000163 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 637887000164 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 637887000165 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637887000166 ligand binding site [chemical binding]; other site 637887000167 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 637887000168 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 637887000169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887000170 S-adenosylmethionine binding site [chemical binding]; other site 637887000171 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637887000172 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 637887000173 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 637887000174 SLBB domain; Region: SLBB; pfam10531 637887000175 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887000176 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 637887000177 FMN-binding domain; Region: FMN_bind; cl01081 637887000178 electron transport complex RsxE subunit; Provisional; Region: PRK12405 637887000179 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 637887000180 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878 637887000181 Putative Fe-S cluster; Region: FeS; cl17515 637887000182 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637887000183 threonine dehydratase; Provisional; Region: PRK08198 637887000184 shikimate kinase; Reviewed; Region: aroK; PRK00131 637887000185 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 637887000186 ADP binding site [chemical binding]; other site 637887000187 magnesium binding site [ion binding]; other site 637887000188 putative shikimate binding site; other site 637887000189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887000190 Coenzyme A binding pocket [chemical binding]; other site 637887000191 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 637887000192 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637887000193 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637887000194 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637887000195 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 637887000196 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 637887000197 N- and C-terminal domain interface [polypeptide binding]; other site 637887000198 active site 637887000199 MgATP binding site [chemical binding]; other site 637887000200 catalytic site [active] 637887000201 metal binding site [ion binding]; metal-binding site 637887000202 putative glycerol binding site [chemical binding]; other site 637887000203 putative homotetramer interface [polypeptide binding]; other site 637887000204 putative homodimer interface [polypeptide binding]; other site 637887000205 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637887000206 TPP-binding site [chemical binding]; other site 637887000207 dimer interface [polypeptide binding]; other site 637887000208 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637887000209 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637887000210 PYR/PP interface [polypeptide binding]; other site 637887000211 dimer interface [polypeptide binding]; other site 637887000212 TPP binding site [chemical binding]; other site 637887000213 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637887000214 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637887000215 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 637887000216 inhibitor binding site; inhibition site 637887000217 catalytic Zn binding site [ion binding]; other site 637887000218 structural Zn binding site [ion binding]; other site 637887000219 NADP binding site [chemical binding]; other site 637887000220 tetramer interface [polypeptide binding]; other site 637887000221 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313 637887000222 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637887000223 putative ligand binding site [chemical binding]; other site 637887000224 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637887000225 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637887000226 Walker A/P-loop; other site 637887000227 ATP binding site [chemical binding]; other site 637887000228 Q-loop/lid; other site 637887000229 ABC transporter signature motif; other site 637887000230 Walker B; other site 637887000231 D-loop; other site 637887000232 H-loop/switch region; other site 637887000233 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637887000234 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637887000235 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637887000236 TM-ABC transporter signature motif; other site 637887000237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637887000238 catalytic core [active] 637887000239 SWIM zinc finger; Region: SWIM; pfam04434 637887000240 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 637887000241 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 637887000242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887000243 ATP binding site [chemical binding]; other site 637887000244 putative Mg++ binding site [ion binding]; other site 637887000245 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637887000246 nucleotide binding region [chemical binding]; other site 637887000247 ATP-binding site [chemical binding]; other site 637887000248 oligoendopeptidase F; Region: pepF; TIGR00181 637887000249 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 637887000250 active site 637887000251 Zn binding site [ion binding]; other site 637887000252 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 637887000253 homodimer interface [polypeptide binding]; other site 637887000254 chemical substrate binding site [chemical binding]; other site 637887000255 oligomer interface [polypeptide binding]; other site 637887000256 metal binding site [ion binding]; metal-binding site 637887000257 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887000258 Interdomain contacts; other site 637887000259 Cytokine receptor motif; other site 637887000260 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887000261 Interdomain contacts; other site 637887000262 Cytokine receptor motif; other site 637887000263 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887000264 Interdomain contacts; other site 637887000265 Cytokine receptor motif; other site 637887000266 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887000267 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887000268 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887000269 S-layer homology domain; Region: SLH; pfam00395 637887000270 S-layer homology domain; Region: SLH; pfam00395 637887000271 S-layer homology domain; Region: SLH; pfam00395 637887000272 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637887000273 nucleoside/Zn binding site; other site 637887000274 dimer interface [polypeptide binding]; other site 637887000275 catalytic motif [active] 637887000276 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 637887000277 3D domain; Region: 3D; cl01439 637887000278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637887000279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637887000280 DNA binding site [nucleotide binding] 637887000281 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 637887000282 putative dimerization interface [polypeptide binding]; other site 637887000283 putative ligand binding site [chemical binding]; other site 637887000284 Cellulose binding domain; Region: CBM_3; smart01067 637887000285 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 637887000286 calcium mediated ligand binding site; other site 637887000287 intermolecular salt bridges; other site 637887000288 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 637887000289 S-layer homology domain; Region: SLH; pfam00395 637887000290 S-layer homology domain; Region: SLH; pfam00395 637887000291 S-layer homology domain; Region: SLH; pfam00395 637887000292 YabG peptidase U57; Region: Peptidase_U57; cl05250 637887000293 DNA topoisomerase III; Provisional; Region: PRK07726 637887000294 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637887000295 active site 637887000296 putative interdomain interaction site [polypeptide binding]; other site 637887000297 putative metal-binding site [ion binding]; other site 637887000298 putative nucleotide binding site [chemical binding]; other site 637887000299 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637887000300 domain I; other site 637887000301 DNA binding groove [nucleotide binding] 637887000302 phosphate binding site [ion binding]; other site 637887000303 domain II; other site 637887000304 domain III; other site 637887000305 nucleotide binding site [chemical binding]; other site 637887000306 catalytic site [active] 637887000307 domain IV; other site 637887000308 Domain of unknown function (DUF368); Region: DUF368; pfam04018 637887000309 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 637887000310 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637887000311 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 637887000312 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 637887000313 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637887000314 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637887000315 protein binding site [polypeptide binding]; other site 637887000316 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637887000317 nucleoside/Zn binding site; other site 637887000318 dimer interface [polypeptide binding]; other site 637887000319 catalytic motif [active] 637887000320 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 637887000321 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637887000322 PYR/PP interface [polypeptide binding]; other site 637887000323 dimer interface [polypeptide binding]; other site 637887000324 TPP binding site [chemical binding]; other site 637887000325 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637887000326 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637887000327 TPP-binding site [chemical binding]; other site 637887000328 dimer interface [polypeptide binding]; other site 637887000329 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 637887000330 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637887000331 putative valine binding site [chemical binding]; other site 637887000332 dimer interface [polypeptide binding]; other site 637887000333 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 637887000334 ketol-acid reductoisomerase; Provisional; Region: PRK05479 637887000335 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 637887000336 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637887000337 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 637887000338 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 637887000339 active site 637887000340 catalytic residues [active] 637887000341 metal binding site [ion binding]; metal-binding site 637887000342 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 637887000343 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887000344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887000345 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 637887000346 Predicted transcriptional regulator [Transcription]; Region: COG1959 637887000347 Transcriptional regulator; Region: Rrf2; cl17282 637887000348 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 637887000349 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 637887000350 tRNA; other site 637887000351 putative tRNA binding site [nucleotide binding]; other site 637887000352 putative NADP binding site [chemical binding]; other site 637887000353 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 637887000354 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 637887000355 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 637887000356 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 637887000357 domain interfaces; other site 637887000358 active site 637887000359 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 637887000360 active site 637887000361 SAM binding site [chemical binding]; other site 637887000362 homodimer interface [polypeptide binding]; other site 637887000363 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 637887000364 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 637887000365 active site 637887000366 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 637887000367 dimer interface [polypeptide binding]; other site 637887000368 active site 637887000369 Schiff base residues; other site 637887000370 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 637887000371 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637887000372 inhibitor-cofactor binding pocket; inhibition site 637887000373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887000374 catalytic residue [active] 637887000375 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637887000376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887000377 substrate binding pocket [chemical binding]; other site 637887000378 membrane-bound complex binding site; other site 637887000379 hinge residues; other site 637887000380 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 637887000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887000382 dimer interface [polypeptide binding]; other site 637887000383 conserved gate region; other site 637887000384 putative PBP binding loops; other site 637887000385 ABC-ATPase subunit interface; other site 637887000386 sulfate transport protein; Provisional; Region: cysT; CHL00187 637887000387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887000388 dimer interface [polypeptide binding]; other site 637887000389 conserved gate region; other site 637887000390 putative PBP binding loops; other site 637887000391 ABC-ATPase subunit interface; other site 637887000392 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 637887000393 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 637887000394 Walker A/P-loop; other site 637887000395 ATP binding site [chemical binding]; other site 637887000396 Q-loop/lid; other site 637887000397 ABC transporter signature motif; other site 637887000398 Walker B; other site 637887000399 D-loop; other site 637887000400 H-loop/switch region; other site 637887000401 TOBE-like domain; Region: TOBE_3; pfam12857 637887000402 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 637887000403 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637887000404 Active Sites [active] 637887000405 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 637887000406 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637887000407 Active Sites [active] 637887000408 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 637887000409 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 637887000410 CysD dimerization site [polypeptide binding]; other site 637887000411 G1 box; other site 637887000412 putative GEF interaction site [polypeptide binding]; other site 637887000413 GTP/Mg2+ binding site [chemical binding]; other site 637887000414 Switch I region; other site 637887000415 G2 box; other site 637887000416 G3 box; other site 637887000417 Switch II region; other site 637887000418 G4 box; other site 637887000419 G5 box; other site 637887000420 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 637887000421 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 637887000422 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 637887000423 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 637887000424 thiS-thiF/thiG interaction site; other site 637887000425 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 637887000426 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 637887000427 ATP binding site [chemical binding]; other site 637887000428 substrate interface [chemical binding]; other site 637887000429 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 637887000430 MPN+ (JAMM) motif; other site 637887000431 Zinc-binding site [ion binding]; other site 637887000432 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 637887000433 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637887000434 4Fe-4S binding domain; Region: Fer4; pfam00037 637887000435 4Fe-4S binding domain; Region: Fer4; pfam00037 637887000436 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 637887000437 CPxP motif; other site 637887000438 Putative zinc-finger; Region: zf-HC2; pfam13490 637887000439 Sporulation and spore germination; Region: Germane; pfam10646 637887000440 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 637887000441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887000442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887000443 DNA binding residues [nucleotide binding] 637887000444 potential frameshift: common BLAST hit: gi|125975030|ref|YP_001038940.1| signal transduction histidine kinase regulating citrate/malate 637887000445 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 637887000446 ATP binding site [chemical binding]; other site 637887000447 Mg2+ binding site [ion binding]; other site 637887000448 G-X-G motif; other site 637887000449 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 637887000450 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 637887000451 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887000452 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887000453 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 637887000454 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887000455 FeS/SAM binding site; other site 637887000456 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 637887000457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887000458 FeS/SAM binding site; other site 637887000459 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 637887000460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887000461 FeS/SAM binding site; other site 637887000462 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 637887000463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637887000464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887000465 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 637887000466 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 637887000467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887000468 FeS/SAM binding site; other site 637887000469 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 637887000470 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 637887000471 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 637887000472 Probable Catalytic site; other site 637887000473 metal-binding site 637887000474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637887000475 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637887000476 NAD(P) binding site [chemical binding]; other site 637887000477 active site 637887000478 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 637887000479 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637887000480 inhibitor-cofactor binding pocket; inhibition site 637887000481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887000482 catalytic residue [active] 637887000483 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 637887000484 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 637887000485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637887000486 NAD(P) binding site [chemical binding]; other site 637887000487 active site 637887000488 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 637887000489 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 637887000490 substrate binding site; other site 637887000491 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887000492 MULE transposase domain; Region: MULE; pfam10551 637887000493 DinB superfamily; Region: DinB_2; pfam12867 637887000494 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 637887000495 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 637887000496 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637887000497 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637887000498 Walker A/P-loop; other site 637887000499 ATP binding site [chemical binding]; other site 637887000500 Q-loop/lid; other site 637887000501 ABC transporter signature motif; other site 637887000502 Walker B; other site 637887000503 D-loop; other site 637887000504 H-loop/switch region; other site 637887000505 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637887000506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887000507 dimer interface [polypeptide binding]; other site 637887000508 conserved gate region; other site 637887000509 putative PBP binding loops; other site 637887000510 ABC-ATPase subunit interface; other site 637887000511 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637887000512 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 637887000513 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 637887000514 putative active site [active] 637887000515 putative metal binding residues [ion binding]; other site 637887000516 signature motif; other site 637887000517 putative dimer interface [polypeptide binding]; other site 637887000518 putative phosphate binding site [ion binding]; other site 637887000519 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 637887000520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637887000521 nucleotide binding site [chemical binding]; other site 637887000522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887000523 Zn2+ binding site [ion binding]; other site 637887000524 Mg2+ binding site [ion binding]; other site 637887000525 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637887000526 1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181 637887000527 dimer interface [polypeptide binding]; other site 637887000528 active site 637887000529 metal binding site [ion binding]; metal-binding site 637887000530 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 637887000531 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637887000532 active site 637887000533 metal binding site [ion binding]; metal-binding site 637887000534 homotetramer interface [polypeptide binding]; other site 637887000535 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 637887000536 dihydropteroate synthase; Region: DHPS; TIGR01496 637887000537 substrate binding pocket [chemical binding]; other site 637887000538 dimer interface [polypeptide binding]; other site 637887000539 inhibitor binding site; inhibition site 637887000540 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 637887000541 homooctamer interface [polypeptide binding]; other site 637887000542 active site 637887000543 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 637887000544 catalytic center binding site [active] 637887000545 ATP binding site [chemical binding]; other site 637887000546 Biotin operon repressor [Transcription]; Region: BirA; COG1654 637887000547 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 637887000548 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 637887000549 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 637887000550 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 637887000551 active site 637887000552 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637887000553 nucleotide binding site [chemical binding]; other site 637887000554 Type III pantothenate kinase; Region: Pan_kinase; cl17198 637887000555 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 637887000556 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887000557 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 637887000558 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 637887000559 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887000560 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887000561 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 637887000562 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 637887000563 peptide chain release factor 1; Validated; Region: prfA; PRK00591 637887000564 This domain is found in peptide chain release factors; Region: PCRF; smart00937 637887000565 RF-1 domain; Region: RF-1; pfam00472 637887000566 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 637887000567 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 637887000568 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 637887000569 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637887000570 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 637887000571 active site 637887000572 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 637887000573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887000574 active site 637887000575 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 637887000576 catalytic motif [active] 637887000577 Zn binding site [ion binding]; other site 637887000578 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 637887000579 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 637887000580 Mg++ binding site [ion binding]; other site 637887000581 putative catalytic motif [active] 637887000582 substrate binding site [chemical binding]; other site 637887000583 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 637887000584 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 637887000585 active site 637887000586 homodimer interface [polypeptide binding]; other site 637887000587 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 637887000588 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 637887000589 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 637887000590 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 637887000591 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 637887000592 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 637887000593 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 637887000594 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 637887000595 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 637887000596 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637887000597 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 637887000598 beta subunit interaction interface [polypeptide binding]; other site 637887000599 Walker A motif; other site 637887000600 ATP binding site [chemical binding]; other site 637887000601 Walker B motif; other site 637887000602 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637887000603 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 637887000604 core domain interface [polypeptide binding]; other site 637887000605 delta subunit interface [polypeptide binding]; other site 637887000606 epsilon subunit interface [polypeptide binding]; other site 637887000607 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 637887000608 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637887000609 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 637887000610 alpha subunit interaction interface [polypeptide binding]; other site 637887000611 Walker A motif; other site 637887000612 ATP binding site [chemical binding]; other site 637887000613 Walker B motif; other site 637887000614 inhibitor binding site; inhibition site 637887000615 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637887000616 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 637887000617 gamma subunit interface [polypeptide binding]; other site 637887000618 epsilon subunit interface [polypeptide binding]; other site 637887000619 LBP interface [polypeptide binding]; other site 637887000620 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 637887000621 RecT family; Region: RecT; cl04285 637887000622 S-layer homology domain; Region: SLH; pfam00395 637887000623 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887000624 Interdomain contacts; other site 637887000625 Cytokine receptor motif; other site 637887000626 S-layer homology domain; Region: SLH; pfam00395 637887000627 S-layer homology domain; Region: SLH; pfam00395 637887000628 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 637887000629 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 637887000630 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637887000631 hinge; other site 637887000632 active site 637887000633 stage II sporulation protein D; Region: spore_II_D; TIGR02870 637887000634 Stage II sporulation protein; Region: SpoIID; pfam08486 637887000635 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637887000636 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 637887000637 Peptidase family M23; Region: Peptidase_M23; pfam01551 637887000638 Stage III sporulation protein D; Region: SpoIIID; pfam12116 637887000639 rod shape-determining protein Mbl; Provisional; Region: PRK13928 637887000640 MreB and similar proteins; Region: MreB_like; cd10225 637887000641 nucleotide binding site [chemical binding]; other site 637887000642 Mg binding site [ion binding]; other site 637887000643 putative protofilament interaction site [polypeptide binding]; other site 637887000644 RodZ interaction site [polypeptide binding]; other site 637887000645 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 637887000646 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637887000647 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 637887000648 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 637887000649 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637887000650 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637887000651 Rod binding protein; Region: Rod-binding; pfam10135 637887000652 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 637887000653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887000654 Walker A/P-loop; other site 637887000655 ATP binding site [chemical binding]; other site 637887000656 Q-loop/lid; other site 637887000657 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 637887000658 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 637887000659 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637887000660 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887000661 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637887000662 pur operon repressor; Provisional; Region: PRK09213 637887000663 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 637887000664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887000665 active site 637887000666 regulatory protein SpoVG; Reviewed; Region: PRK13259 637887000667 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 637887000668 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 637887000669 Substrate binding site; other site 637887000670 Mg++ binding site; other site 637887000671 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 637887000672 active site 637887000673 substrate binding site [chemical binding]; other site 637887000674 CoA binding site [chemical binding]; other site 637887000675 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 637887000676 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 637887000677 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887000678 active site 637887000679 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 637887000680 putative active site [active] 637887000681 catalytic residue [active] 637887000682 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 637887000683 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 637887000684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887000685 ATP binding site [chemical binding]; other site 637887000686 putative Mg++ binding site [ion binding]; other site 637887000687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637887000688 nucleotide binding region [chemical binding]; other site 637887000689 ATP-binding site [chemical binding]; other site 637887000690 TRCF domain; Region: TRCF; pfam03461 637887000691 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 637887000692 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 637887000693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887000694 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637887000695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887000696 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 637887000697 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 637887000698 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 637887000699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887000700 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637887000701 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 637887000702 O-Antigen ligase; Region: Wzy_C; pfam04932 637887000703 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 637887000704 ligand binding site; other site 637887000705 tetramer interface; other site 637887000706 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 637887000707 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 637887000708 active site 637887000709 homodimer interface [polypeptide binding]; other site 637887000710 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 637887000711 NeuB family; Region: NeuB; pfam03102 637887000712 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 637887000713 NeuB binding interface [polypeptide binding]; other site 637887000714 putative substrate binding site [chemical binding]; other site 637887000715 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 637887000716 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 637887000717 putative trimer interface [polypeptide binding]; other site 637887000718 putative CoA binding site [chemical binding]; other site 637887000719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 637887000720 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 637887000721 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 637887000722 Substrate binding site; other site 637887000723 metal-binding site 637887000724 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 637887000725 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637887000726 inhibitor-cofactor binding pocket; inhibition site 637887000727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887000728 catalytic residue [active] 637887000729 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 637887000730 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 637887000731 NAD binding site [chemical binding]; other site 637887000732 substrate binding site [chemical binding]; other site 637887000733 active site 637887000734 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 637887000735 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637887000736 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 637887000737 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637887000738 Bacterial sugar transferase; Region: Bac_transf; pfam02397 637887000739 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 637887000740 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 637887000741 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637887000742 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 637887000743 NAD(P) binding site [chemical binding]; other site 637887000744 homodimer interface [polypeptide binding]; other site 637887000745 substrate binding site [chemical binding]; other site 637887000746 active site 637887000747 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 637887000748 Chain length determinant protein; Region: Wzz; cl15801 637887000749 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 637887000750 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637887000751 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 637887000752 stage V sporulation protein T; Region: spore_V_T; TIGR02851 637887000753 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 637887000754 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 637887000755 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 637887000756 homodimer interface [polypeptide binding]; other site 637887000757 metal binding site [ion binding]; metal-binding site 637887000758 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 637887000759 homodimer interface [polypeptide binding]; other site 637887000760 active site 637887000761 putative chemical substrate binding site [chemical binding]; other site 637887000762 metal binding site [ion binding]; metal-binding site 637887000763 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 637887000764 IHF dimer interface [polypeptide binding]; other site 637887000765 IHF - DNA interface [nucleotide binding]; other site 637887000766 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887000767 RNA binding surface [nucleotide binding]; other site 637887000768 YabP family; Region: YabP; cl06766 637887000769 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 637887000770 Septum formation initiator; Region: DivIC; cl17659 637887000771 hypothetical protein; Provisional; Region: PRK05807 637887000772 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 637887000773 RNA binding site [nucleotide binding]; other site 637887000774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887000775 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887000776 dimer interface [polypeptide binding]; other site 637887000777 putative CheW interface [polypeptide binding]; other site 637887000778 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 637887000779 ABC1 family; Region: ABC1; cl17513 637887000780 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637887000781 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 637887000782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637887000783 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637887000784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887000785 motif II; other site 637887000786 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637887000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637887000788 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 637887000789 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 637887000790 hypothetical protein; Provisional; Region: PRK06771 637887000791 TraB family; Region: TraB; pfam01963 637887000792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887000793 binding surface 637887000794 TPR motif; other site 637887000795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887000796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887000797 binding surface 637887000798 TPR motif; other site 637887000799 TPR repeat; Region: TPR_11; pfam13414 637887000800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887000801 binding surface 637887000802 TPR motif; other site 637887000803 TPR repeat; Region: TPR_11; pfam13414 637887000804 TPR repeat; Region: TPR_11; pfam13414 637887000805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887000806 binding surface 637887000807 TPR motif; other site 637887000808 TPR repeat; Region: TPR_11; pfam13414 637887000809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887000810 binding surface 637887000811 TPR motif; other site 637887000812 Tetratricopeptide repeat; Region: TPR_16; pfam13432 637887000813 TPR repeat; Region: TPR_11; pfam13414 637887000814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887000815 TPR motif; other site 637887000816 binding surface 637887000817 TPR repeat; Region: TPR_11; pfam13414 637887000818 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 637887000819 Active site serine [active] 637887000820 stage II sporulation protein E; Region: spore_II_E; TIGR02865 637887000821 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 637887000822 PilZ domain; Region: PilZ; pfam07238 637887000823 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 637887000824 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 637887000825 FMN binding site [chemical binding]; other site 637887000826 active site 637887000827 catalytic residues [active] 637887000828 substrate binding site [chemical binding]; other site 637887000829 Competence protein A; Region: Competence_A; pfam11104 637887000830 Cell division protein FtsA; Region: FtsA; cl17206 637887000831 Cell division protein FtsA; Region: FtsA; pfam14450 637887000832 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 637887000833 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637887000834 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 637887000835 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637887000836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637887000837 DNA-binding site [nucleotide binding]; DNA binding site 637887000838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887000839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887000840 homodimer interface [polypeptide binding]; other site 637887000841 catalytic residue [active] 637887000842 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 637887000843 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 637887000844 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 637887000845 trimer interface [polypeptide binding]; other site 637887000846 active site 637887000847 substrate binding site [chemical binding]; other site 637887000848 CoA binding site [chemical binding]; other site 637887000849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887000850 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637887000851 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 637887000852 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 637887000853 O-Antigen ligase; Region: Wzy_C; cl04850 637887000854 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 637887000855 Uncharacterized conserved protein [Function unknown]; Region: COG0062 637887000856 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 637887000857 putative substrate binding site [chemical binding]; other site 637887000858 putative ATP binding site [chemical binding]; other site 637887000859 alanine racemase; Reviewed; Region: alr; PRK00053 637887000860 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 637887000861 active site 637887000862 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637887000863 dimer interface [polypeptide binding]; other site 637887000864 substrate binding site [chemical binding]; other site 637887000865 catalytic residues [active] 637887000866 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 637887000867 PemK-like protein; Region: PemK; pfam02452 637887000868 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 637887000869 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 637887000870 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887000871 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637887000872 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 637887000873 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 637887000874 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637887000875 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637887000876 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637887000877 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 637887000878 transketolase; Reviewed; Region: PRK05899 637887000879 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637887000880 TPP-binding site [chemical binding]; other site 637887000881 dimer interface [polypeptide binding]; other site 637887000882 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637887000883 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637887000884 PYR/PP interface [polypeptide binding]; other site 637887000885 dimer interface [polypeptide binding]; other site 637887000886 TPP binding site [chemical binding]; other site 637887000887 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637887000888 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 637887000889 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637887000890 Walker A/P-loop; other site 637887000891 ATP binding site [chemical binding]; other site 637887000892 Q-loop/lid; other site 637887000893 ABC transporter signature motif; other site 637887000894 Walker B; other site 637887000895 D-loop; other site 637887000896 H-loop/switch region; other site 637887000897 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 637887000898 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 637887000899 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 637887000900 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 637887000901 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 637887000902 Uncharacterized membrane protein [Function unknown]; Region: COG3949 637887000903 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 637887000904 Colicin V production protein; Region: Colicin_V; pfam02674 637887000905 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 637887000906 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 637887000907 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637887000908 PYR/PP interface [polypeptide binding]; other site 637887000909 dimer interface [polypeptide binding]; other site 637887000910 TPP binding site [chemical binding]; other site 637887000911 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637887000912 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637887000913 TPP-binding site [chemical binding]; other site 637887000914 dimer interface [polypeptide binding]; other site 637887000915 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 637887000916 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 637887000917 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 637887000918 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 637887000919 putative homodimer interface [polypeptide binding]; other site 637887000920 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 637887000921 heterodimer interface [polypeptide binding]; other site 637887000922 homodimer interface [polypeptide binding]; other site 637887000923 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 637887000924 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 637887000925 23S rRNA interface [nucleotide binding]; other site 637887000926 L7/L12 interface [polypeptide binding]; other site 637887000927 putative thiostrepton binding site; other site 637887000928 L25 interface [polypeptide binding]; other site 637887000929 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 637887000930 mRNA/rRNA interface [nucleotide binding]; other site 637887000931 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 637887000932 23S rRNA interface [nucleotide binding]; other site 637887000933 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 637887000934 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 637887000935 core dimer interface [polypeptide binding]; other site 637887000936 peripheral dimer interface [polypeptide binding]; other site 637887000937 L10 interface [polypeptide binding]; other site 637887000938 L11 interface [polypeptide binding]; other site 637887000939 putative EF-Tu interaction site [polypeptide binding]; other site 637887000940 putative EF-G interaction site [polypeptide binding]; other site 637887000941 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 637887000942 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 637887000943 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 637887000944 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637887000945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637887000946 RPB1 interaction site [polypeptide binding]; other site 637887000947 RPB12 interaction site [polypeptide binding]; other site 637887000948 RPB10 interaction site [polypeptide binding]; other site 637887000949 RPB11 interaction site [polypeptide binding]; other site 637887000950 RPB3 interaction site [polypeptide binding]; other site 637887000951 RPB12 interaction site [polypeptide binding]; other site 637887000952 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 637887000953 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 637887000954 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 637887000955 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 637887000956 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 637887000957 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637887000958 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 637887000959 G-loop; other site 637887000960 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 637887000961 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637887000962 DNA binding site [nucleotide binding] 637887000963 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 637887000964 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 637887000965 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 637887000966 S17 interaction site [polypeptide binding]; other site 637887000967 S8 interaction site; other site 637887000968 16S rRNA interaction site [nucleotide binding]; other site 637887000969 streptomycin interaction site [chemical binding]; other site 637887000970 23S rRNA interaction site [nucleotide binding]; other site 637887000971 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 637887000972 30S ribosomal protein S7; Validated; Region: PRK05302 637887000973 elongation factor G; Reviewed; Region: PRK00007 637887000974 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 637887000975 G1 box; other site 637887000976 putative GEF interaction site [polypeptide binding]; other site 637887000977 GTP/Mg2+ binding site [chemical binding]; other site 637887000978 Switch I region; other site 637887000979 G2 box; other site 637887000980 G3 box; other site 637887000981 Switch II region; other site 637887000982 G4 box; other site 637887000983 G5 box; other site 637887000984 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 637887000985 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 637887000986 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 637887000987 elongation factor Tu; Reviewed; Region: PRK00049 637887000988 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 637887000989 G1 box; other site 637887000990 GEF interaction site [polypeptide binding]; other site 637887000991 GTP/Mg2+ binding site [chemical binding]; other site 637887000992 Switch I region; other site 637887000993 G2 box; other site 637887000994 G3 box; other site 637887000995 Switch II region; other site 637887000996 G4 box; other site 637887000997 G5 box; other site 637887000998 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637887000999 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 637887001000 Antibiotic Binding Site [chemical binding]; other site 637887001001 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 637887001002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887001003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887001004 DNA binding residues [nucleotide binding] 637887001005 Putative zinc-finger; Region: zf-HC2; pfam13490 637887001006 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 637887001007 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637887001008 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 637887001009 VanW like protein; Region: VanW; pfam04294 637887001010 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637887001011 dimerization domain swap beta strand [polypeptide binding]; other site 637887001012 regulatory protein interface [polypeptide binding]; other site 637887001013 active site 637887001014 regulatory phosphorylation site [posttranslational modification]; other site 637887001015 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637887001016 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 637887001017 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637887001018 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637887001019 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637887001020 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 637887001021 GIY-YIG motif/motif A; other site 637887001022 active site 637887001023 catalytic site [active] 637887001024 putative DNA binding site [nucleotide binding]; other site 637887001025 metal binding site [ion binding]; metal-binding site 637887001026 UvrB/uvrC motif; Region: UVR; pfam02151 637887001027 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 637887001028 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 637887001029 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637887001030 putative active site [active] 637887001031 putative metal binding site [ion binding]; other site 637887001032 trigger factor; Provisional; Region: tig; PRK01490 637887001033 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637887001034 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 637887001035 Clp protease; Region: CLP_protease; pfam00574 637887001036 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637887001037 oligomer interface [polypeptide binding]; other site 637887001038 active site residues [active] 637887001039 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 637887001040 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 637887001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887001042 Walker A motif; other site 637887001043 ATP binding site [chemical binding]; other site 637887001044 Walker B motif; other site 637887001045 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637887001046 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 637887001047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887001048 Walker A motif; other site 637887001049 ATP binding site [chemical binding]; other site 637887001050 Walker B motif; other site 637887001051 arginine finger; other site 637887001052 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637887001053 UGMP family protein; Validated; Region: PRK09604 637887001054 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 637887001055 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 637887001056 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637887001057 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637887001058 catalytic residue [active] 637887001059 Protein of unknown function (DUF402); Region: DUF402; pfam04167 637887001060 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 637887001061 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 637887001062 active site 637887001063 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 637887001064 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 637887001065 SmpB-tmRNA interface; other site 637887001066 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 637887001067 dimer interface [polypeptide binding]; other site 637887001068 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 637887001069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887001070 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 637887001071 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887001072 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 637887001073 potassium/proton antiporter; Reviewed; Region: PRK05326 637887001074 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637887001075 TrkA-C domain; Region: TrkA_C; pfam02080 637887001076 TrkA-C domain; Region: TrkA_C; pfam02080 637887001077 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 637887001078 active site 637887001079 NTP binding site [chemical binding]; other site 637887001080 metal binding triad [ion binding]; metal-binding site 637887001081 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637887001082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 637887001083 endoglucanase; Region: PLN02420 637887001084 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887001085 Cellulose binding domain; Region: CBM_3; cl03026 637887001086 Cellulose binding domain; Region: CBM_3; smart01067 637887001087 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001088 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001089 endoglucanase; Region: PLN02420 637887001090 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887001091 Cellulose binding domain; Region: CBM_3; smart01067 637887001092 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001093 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001094 WYL domain; Region: WYL; pfam13280 637887001095 WYL domain; Region: WYL; pfam13280 637887001096 TROVE domain; Region: TROVE; pfam05731 637887001097 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 637887001098 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 637887001099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887001100 S-adenosylmethionine binding site [chemical binding]; other site 637887001101 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 637887001102 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 637887001103 active site 637887001104 metal binding site [ion binding]; metal-binding site 637887001105 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 637887001106 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 637887001107 Hemerythrin-like domain; Region: Hr-like; cd12108 637887001108 Fe binding site [ion binding]; other site 637887001109 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 637887001110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887001111 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637887001112 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637887001113 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637887001114 ligand binding site [chemical binding]; other site 637887001115 flexible hinge region; other site 637887001116 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637887001117 putative switch regulator; other site 637887001118 non-specific DNA interactions [nucleotide binding]; other site 637887001119 DNA binding site [nucleotide binding] 637887001120 sequence specific DNA binding site [nucleotide binding]; other site 637887001121 putative cAMP binding site [chemical binding]; other site 637887001122 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 637887001123 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 637887001124 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 637887001125 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637887001126 active site 637887001127 nucleotide binding site [chemical binding]; other site 637887001128 HIGH motif; other site 637887001129 KMSKS motif; other site 637887001130 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 637887001131 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 637887001132 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 637887001133 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637887001134 amidase catalytic site [active] 637887001135 Zn binding residues [ion binding]; other site 637887001136 substrate binding site [chemical binding]; other site 637887001137 S-layer homology domain; Region: SLH; pfam00395 637887001138 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 637887001139 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 637887001140 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 637887001141 B12 binding site [chemical binding]; other site 637887001142 cobalt ligand [ion binding]; other site 637887001143 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 637887001144 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 637887001145 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 637887001146 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 637887001147 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 637887001148 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637887001149 catalytic loop [active] 637887001150 iron binding site [ion binding]; other site 637887001151 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 637887001152 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 637887001153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887001154 substrate binding pocket [chemical binding]; other site 637887001155 membrane-bound complex binding site; other site 637887001156 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637887001157 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637887001158 Walker A/P-loop; other site 637887001159 ATP binding site [chemical binding]; other site 637887001160 Q-loop/lid; other site 637887001161 ABC transporter signature motif; other site 637887001162 Walker B; other site 637887001163 D-loop; other site 637887001164 H-loop/switch region; other site 637887001165 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637887001166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887001167 ABC-ATPase subunit interface; other site 637887001168 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 637887001169 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637887001170 acyl-activating enzyme (AAE) consensus motif; other site 637887001171 AMP binding site [chemical binding]; other site 637887001172 active site 637887001173 CoA binding site [chemical binding]; other site 637887001174 aminotransferase; Validated; Region: PRK07777 637887001175 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887001176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887001177 homodimer interface [polypeptide binding]; other site 637887001178 catalytic residue [active] 637887001179 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 637887001180 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 637887001181 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 637887001182 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 637887001183 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 637887001184 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637887001185 dimer interface [polypeptide binding]; other site 637887001186 PYR/PP interface [polypeptide binding]; other site 637887001187 TPP binding site [chemical binding]; other site 637887001188 substrate binding site [chemical binding]; other site 637887001189 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637887001190 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 637887001191 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 637887001192 TPP-binding site [chemical binding]; other site 637887001193 putative dimer interface [polypeptide binding]; other site 637887001194 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal; Region: U1snRNP70_N; pfam12220 637887001195 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637887001196 homotrimer interaction site [polypeptide binding]; other site 637887001197 putative active site [active] 637887001198 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 637887001199 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637887001200 homodimer interface [polypeptide binding]; other site 637887001201 substrate-cofactor binding pocket; other site 637887001202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887001203 catalytic residue [active] 637887001204 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 637887001205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887001206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887001207 homodimer interface [polypeptide binding]; other site 637887001208 catalytic residue [active] 637887001209 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887001210 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 637887001211 ACS interaction site; other site 637887001212 CODH interaction site; other site 637887001213 metal cluster binding site [ion binding]; other site 637887001214 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 637887001215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887001216 substrate binding pocket [chemical binding]; other site 637887001217 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637887001218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887001219 dimer interface [polypeptide binding]; other site 637887001220 conserved gate region; other site 637887001221 putative PBP binding loops; other site 637887001222 ABC-ATPase subunit interface; other site 637887001223 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637887001224 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637887001225 Walker A/P-loop; other site 637887001226 ATP binding site [chemical binding]; other site 637887001227 Q-loop/lid; other site 637887001228 ABC transporter signature motif; other site 637887001229 Walker B; other site 637887001230 D-loop; other site 637887001231 H-loop/switch region; other site 637887001232 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887001233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637887001234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637887001235 DNA binding site [nucleotide binding] 637887001236 domain linker motif; other site 637887001237 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637887001238 dimerization interface [polypeptide binding]; other site 637887001239 ligand binding site [chemical binding]; other site 637887001240 S-layer homology domain; Region: SLH; pfam00395 637887001241 S-layer homology domain; Region: SLH; pfam00395 637887001242 S-layer homology domain; Region: SLH; pfam00395 637887001243 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 637887001244 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 637887001245 active site 637887001246 catalytic residues [active] 637887001247 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887001248 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887001249 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887001250 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887001251 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887001252 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 637887001253 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637887001254 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637887001255 PhoU domain; Region: PhoU; pfam01895 637887001256 PhoU domain; Region: PhoU; pfam01895 637887001257 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 637887001258 putative metal binding site [ion binding]; other site 637887001259 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 637887001260 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001261 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001262 endoglucanase; Region: PLN02420 637887001263 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887001264 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001265 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887001268 active site 637887001269 phosphorylation site [posttranslational modification] 637887001270 intermolecular recognition site; other site 637887001271 dimerization interface [polypeptide binding]; other site 637887001272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887001273 DNA binding site [nucleotide binding] 637887001274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887001275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887001276 dimer interface [polypeptide binding]; other site 637887001277 phosphorylation site [posttranslational modification] 637887001278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887001279 ATP binding site [chemical binding]; other site 637887001280 Mg2+ binding site [ion binding]; other site 637887001281 G-X-G motif; other site 637887001282 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 637887001283 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637887001284 active site 637887001285 nucleotide binding site [chemical binding]; other site 637887001286 HIGH motif; other site 637887001287 KMSKS motif; other site 637887001288 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 637887001289 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 637887001290 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637887001291 putative binding surface; other site 637887001292 active site 637887001293 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637887001294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887001295 ATP binding site [chemical binding]; other site 637887001296 Mg2+ binding site [ion binding]; other site 637887001297 G-X-G motif; other site 637887001298 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637887001299 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887001300 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 637887001301 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887001302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887001303 dimer interface [polypeptide binding]; other site 637887001304 putative CheW interface [polypeptide binding]; other site 637887001305 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887001306 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887001307 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 637887001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887001309 S-adenosylmethionine binding site [chemical binding]; other site 637887001310 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 637887001311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887001312 active site 637887001313 phosphorylation site [posttranslational modification] 637887001314 intermolecular recognition site; other site 637887001315 dimerization interface [polypeptide binding]; other site 637887001316 CheB methylesterase; Region: CheB_methylest; pfam01339 637887001317 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637887001318 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637887001319 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637887001320 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637887001321 Domain of unknown function DUF21; Region: DUF21; pfam01595 637887001322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637887001323 Transporter associated domain; Region: CorC_HlyC; pfam03471 637887001324 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 637887001325 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 637887001326 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887001327 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001328 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001329 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 637887001330 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 637887001331 active site 637887001332 substrate-binding site [chemical binding]; other site 637887001333 metal-binding site [ion binding] 637887001334 GTP binding site [chemical binding]; other site 637887001335 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 637887001336 30S subunit binding site; other site 637887001337 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 637887001338 Part of AAA domain; Region: AAA_19; pfam13245 637887001339 Family description; Region: UvrD_C_2; pfam13538 637887001340 S-layer homology domain; Region: SLH; pfam00395 637887001341 S-layer homology domain; Region: SLH; pfam00395 637887001342 S-layer homology domain; Region: SLH; pfam00395 637887001343 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 637887001344 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 637887001345 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 637887001346 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 637887001347 putative active site [active] 637887001348 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001349 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001350 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 637887001351 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 637887001352 dimer interface [polypeptide binding]; other site 637887001353 motif 1; other site 637887001354 active site 637887001355 motif 2; other site 637887001356 motif 3; other site 637887001357 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 637887001358 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 637887001359 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 637887001360 histidinol dehydrogenase; Region: hisD; TIGR00069 637887001361 NAD binding site [chemical binding]; other site 637887001362 dimerization interface [polypeptide binding]; other site 637887001363 product binding site; other site 637887001364 substrate binding site [chemical binding]; other site 637887001365 zinc binding site [ion binding]; other site 637887001366 catalytic residues [active] 637887001367 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 637887001368 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887001369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887001370 homodimer interface [polypeptide binding]; other site 637887001371 catalytic residue [active] 637887001372 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 637887001373 putative active site pocket [active] 637887001374 4-fold oligomerization interface [polypeptide binding]; other site 637887001375 metal binding residues [ion binding]; metal-binding site 637887001376 3-fold/trimer interface [polypeptide binding]; other site 637887001377 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 637887001378 ATP binding site [chemical binding]; other site 637887001379 active site 637887001380 substrate binding site [chemical binding]; other site 637887001381 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 637887001382 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 637887001383 putative active site [active] 637887001384 oxyanion strand; other site 637887001385 catalytic triad [active] 637887001386 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 637887001387 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 637887001388 catalytic residues [active] 637887001389 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 637887001390 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 637887001391 substrate binding site [chemical binding]; other site 637887001392 glutamase interaction surface [polypeptide binding]; other site 637887001393 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 637887001394 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 637887001395 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 637887001396 metal binding site [ion binding]; metal-binding site 637887001397 Divergent AAA domain; Region: AAA_4; pfam04326 637887001398 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 637887001399 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 637887001400 oligomerisation interface [polypeptide binding]; other site 637887001401 mobile loop; other site 637887001402 roof hairpin; other site 637887001403 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 637887001404 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 637887001405 ring oligomerisation interface [polypeptide binding]; other site 637887001406 ATP/Mg binding site [chemical binding]; other site 637887001407 stacking interactions; other site 637887001408 hinge regions; other site 637887001409 PilZ domain; Region: PilZ; pfam07238 637887001410 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887001411 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 637887001412 active site 637887001413 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 637887001414 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 637887001415 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637887001416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 637887001417 anti sigma factor interaction site; other site 637887001418 regulatory phosphorylation site [posttranslational modification]; other site 637887001419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637887001420 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 637887001421 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 637887001422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887001423 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637887001424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887001425 DNA binding residues [nucleotide binding] 637887001426 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 637887001427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887001428 ATP binding site [chemical binding]; other site 637887001429 Mg2+ binding site [ion binding]; other site 637887001430 G-X-G motif; other site 637887001431 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 637887001432 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 637887001433 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 637887001434 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 637887001435 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 637887001436 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 637887001437 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 637887001438 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 637887001439 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 637887001440 putative translocon binding site; other site 637887001441 protein-rRNA interface [nucleotide binding]; other site 637887001442 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 637887001443 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 637887001444 G-X-X-G motif; other site 637887001445 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 637887001446 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 637887001447 23S rRNA interface [nucleotide binding]; other site 637887001448 5S rRNA interface [nucleotide binding]; other site 637887001449 putative antibiotic binding site [chemical binding]; other site 637887001450 L25 interface [polypeptide binding]; other site 637887001451 L27 interface [polypeptide binding]; other site 637887001452 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 637887001453 L23 interface [polypeptide binding]; other site 637887001454 signal recognition particle (SRP54) interaction site; other site 637887001455 trigger factor interaction site; other site 637887001456 23S rRNA interface [nucleotide binding]; other site 637887001457 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 637887001458 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 637887001459 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 637887001460 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 637887001461 RNA binding site [nucleotide binding]; other site 637887001462 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 637887001463 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 637887001464 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 637887001465 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 637887001466 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 637887001467 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 637887001468 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637887001469 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637887001470 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 637887001471 5S rRNA interface [nucleotide binding]; other site 637887001472 L27 interface [polypeptide binding]; other site 637887001473 L5 interface [polypeptide binding]; other site 637887001474 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 637887001475 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 637887001476 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 637887001477 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 637887001478 23S rRNA binding site [nucleotide binding]; other site 637887001479 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 637887001480 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 637887001481 SecY translocase; Region: SecY; pfam00344 637887001482 adenylate kinase; Reviewed; Region: adk; PRK00279 637887001483 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 637887001484 AMP-binding site [chemical binding]; other site 637887001485 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 637887001486 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637887001487 active site 637887001488 50S ribosomal protein L14e; Validated; Region: PRK04333 637887001489 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 637887001490 RNA binding site [nucleotide binding]; other site 637887001491 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 637887001492 rRNA binding site [nucleotide binding]; other site 637887001493 predicted 30S ribosome binding site; other site 637887001494 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 637887001495 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 637887001496 30S ribosomal protein S13; Region: bact_S13; TIGR03631 637887001497 30S ribosomal protein S11; Validated; Region: PRK05309 637887001498 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 637887001499 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 637887001500 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887001501 RNA binding surface [nucleotide binding]; other site 637887001502 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 637887001503 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 637887001504 alphaNTD - beta interaction site [polypeptide binding]; other site 637887001505 alphaNTD homodimer interface [polypeptide binding]; other site 637887001506 alphaNTD - beta' interaction site [polypeptide binding]; other site 637887001507 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 637887001508 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 637887001509 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 637887001510 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637887001511 Walker A/P-loop; other site 637887001512 ATP binding site [chemical binding]; other site 637887001513 Q-loop/lid; other site 637887001514 ABC transporter signature motif; other site 637887001515 Walker B; other site 637887001516 D-loop; other site 637887001517 H-loop/switch region; other site 637887001518 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 637887001519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887001520 S-adenosylmethionine binding site [chemical binding]; other site 637887001521 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 637887001522 head completion protein; Provisional; Region: 4; PHA02552 637887001523 EVE domain; Region: EVE; cl00728 637887001524 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 637887001525 DNA methylase; Region: N6_N4_Mtase; pfam01555 637887001526 DNA primase, catalytic core; Region: dnaG; TIGR01391 637887001527 CHC2 zinc finger; Region: zf-CHC2; cl17510 637887001528 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 637887001529 active site 637887001530 metal binding site [ion binding]; metal-binding site 637887001531 interdomain interaction site; other site 637887001532 AAA domain; Region: AAA_25; pfam13481 637887001533 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637887001534 Walker B motif; other site 637887001535 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 637887001536 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887001537 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 637887001538 active site 637887001539 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637887001540 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637887001541 catalytic residues [active] 637887001542 catalytic nucleophile [active] 637887001543 Recombinase; Region: Recombinase; pfam07508 637887001544 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 637887001545 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 637887001546 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637887001547 Walker A/P-loop; other site 637887001548 ATP binding site [chemical binding]; other site 637887001549 Q-loop/lid; other site 637887001550 ABC transporter signature motif; other site 637887001551 Walker B; other site 637887001552 D-loop; other site 637887001553 H-loop/switch region; other site 637887001554 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 637887001555 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637887001556 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637887001557 nucleotide binding site [chemical binding]; other site 637887001558 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 637887001559 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 637887001560 dimerization interface 3.5A [polypeptide binding]; other site 637887001561 active site 637887001562 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 637887001563 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 637887001564 substrate binding site; other site 637887001565 dimer interface; other site 637887001566 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637887001567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887001568 Walker A/P-loop; other site 637887001569 ATP binding site [chemical binding]; other site 637887001570 Q-loop/lid; other site 637887001571 ABC transporter signature motif; other site 637887001572 Walker B; other site 637887001573 D-loop; other site 637887001574 H-loop/switch region; other site 637887001575 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 637887001576 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 637887001577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887001578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 637887001579 dimer interface [polypeptide binding]; other site 637887001580 phosphorylation site [posttranslational modification] 637887001581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887001582 ATP binding site [chemical binding]; other site 637887001583 G-X-G motif; other site 637887001584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887001585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887001586 ATP binding site [chemical binding]; other site 637887001587 Mg2+ binding site [ion binding]; other site 637887001588 G-X-G motif; other site 637887001589 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 637887001590 homotrimer interaction site [polypeptide binding]; other site 637887001591 zinc binding site [ion binding]; other site 637887001592 CDP-binding sites; other site 637887001593 prolyl-tRNA synthetase; Provisional; Region: PRK09194 637887001594 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 637887001595 dimer interface [polypeptide binding]; other site 637887001596 motif 1; other site 637887001597 active site 637887001598 motif 2; other site 637887001599 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 637887001600 putative deacylase active site [active] 637887001601 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637887001602 active site 637887001603 motif 3; other site 637887001604 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 637887001605 anticodon binding site; other site 637887001606 Bacterial SH3 domain; Region: SH3_3; pfam08239 637887001607 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 637887001608 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 637887001609 Pectinesterase; Region: Pectinesterase; pfam01095 637887001610 putative pectinesterase; Region: PLN02432; cl01911 637887001611 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001612 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 637887001613 Amb_all domain; Region: Amb_all; smart00656 637887001614 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001615 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001616 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 637887001617 Ca binding site [ion binding]; other site 637887001618 Ca binding site (active) [ion binding]; other site 637887001619 ligand binding site [chemical binding]; other site 637887001620 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 637887001621 transposase; Provisional; Region: PRK06526 637887001622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887001623 Walker A motif; other site 637887001624 ATP binding site [chemical binding]; other site 637887001625 Walker B motif; other site 637887001626 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637887001627 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637887001628 peptide binding site [polypeptide binding]; other site 637887001629 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 637887001630 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637887001631 Walker A/P-loop; other site 637887001632 ATP binding site [chemical binding]; other site 637887001633 Q-loop/lid; other site 637887001634 ABC transporter signature motif; other site 637887001635 Walker B; other site 637887001636 D-loop; other site 637887001637 H-loop/switch region; other site 637887001638 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637887001639 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637887001640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637887001641 Walker A/P-loop; other site 637887001642 ATP binding site [chemical binding]; other site 637887001643 Q-loop/lid; other site 637887001644 ABC transporter signature motif; other site 637887001645 Walker B; other site 637887001646 D-loop; other site 637887001647 H-loop/switch region; other site 637887001648 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637887001649 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637887001650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637887001651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887001652 dimer interface [polypeptide binding]; other site 637887001653 conserved gate region; other site 637887001654 putative PBP binding loops; other site 637887001655 ABC-ATPase subunit interface; other site 637887001656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637887001657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887001658 dimer interface [polypeptide binding]; other site 637887001659 conserved gate region; other site 637887001660 putative PBP binding loops; other site 637887001661 ABC-ATPase subunit interface; other site 637887001662 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887001663 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 637887001664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637887001665 putative substrate translocation pore; other site 637887001666 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637887001667 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 637887001668 Predicted transcriptional regulators [Transcription]; Region: COG1725 637887001669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637887001670 DNA-binding site [nucleotide binding]; DNA binding site 637887001671 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637887001672 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637887001673 Walker A/P-loop; other site 637887001674 ATP binding site [chemical binding]; other site 637887001675 Q-loop/lid; other site 637887001676 ABC transporter signature motif; other site 637887001677 Walker B; other site 637887001678 D-loop; other site 637887001679 H-loop/switch region; other site 637887001680 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 637887001681 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 637887001682 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887001683 metal binding site [ion binding]; metal-binding site 637887001684 ligand binding site [chemical binding]; other site 637887001685 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001686 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001687 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 637887001688 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 637887001689 NodB motif; other site 637887001690 active site 637887001691 catalytic site [active] 637887001692 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 637887001693 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887001694 metal binding site [ion binding]; metal-binding site 637887001695 ligand binding site [chemical binding]; other site 637887001696 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001697 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001698 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 637887001699 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887001700 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887001701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887001702 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 637887001703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637887001704 ligand binding site [chemical binding]; other site 637887001705 flexible hinge region; other site 637887001706 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637887001707 non-specific DNA interactions [nucleotide binding]; other site 637887001708 DNA binding site [nucleotide binding] 637887001709 sequence specific DNA binding site [nucleotide binding]; other site 637887001710 putative cAMP binding site [chemical binding]; other site 637887001711 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 637887001712 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 637887001713 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637887001714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887001715 substrate binding pocket [chemical binding]; other site 637887001716 membrane-bound complex binding site; other site 637887001717 hinge residues; other site 637887001718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887001719 dimerization interface [polypeptide binding]; other site 637887001720 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887001721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887001722 dimer interface [polypeptide binding]; other site 637887001723 putative CheW interface [polypeptide binding]; other site 637887001724 N-terminal domain of cellodextrin phosphorylase (CDP) and similar proteins; Region: GH94N_CDP_like; cd11752 637887001725 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 637887001726 methionine sulfoxide reductase A; Provisional; Region: PRK14054 637887001727 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 637887001728 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 637887001729 active site 637887001730 FMN binding site [chemical binding]; other site 637887001731 substrate binding site [chemical binding]; other site 637887001732 putative catalytic residue [active] 637887001733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637887001734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637887001735 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637887001736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887001737 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 637887001738 DNA binding residues [nucleotide binding] 637887001739 intracellular protease, PfpI family; Region: PfpI; TIGR01382 637887001740 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 637887001741 conserved cys residue [active] 637887001742 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637887001743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887001744 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 637887001745 Walker A/P-loop; other site 637887001746 ATP binding site [chemical binding]; other site 637887001747 Q-loop/lid; other site 637887001748 ABC transporter signature motif; other site 637887001749 Walker B; other site 637887001750 D-loop; other site 637887001751 H-loop/switch region; other site 637887001752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 637887001753 Coenzyme A binding pocket [chemical binding]; other site 637887001754 Phosphate transporter family; Region: PHO4; pfam01384 637887001755 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 637887001756 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 637887001757 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637887001758 catalytic loop [active] 637887001759 iron binding site [ion binding]; other site 637887001760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637887001761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637887001762 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 637887001763 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 637887001764 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 637887001765 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001766 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637887001767 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001768 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001769 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637887001770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001771 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001772 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637887001773 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001774 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 637887001776 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637887001777 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001778 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887001779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 637887001780 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637887001781 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 637887001782 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637887001783 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637887001784 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 637887001785 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 637887001786 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887001787 ligand binding site [chemical binding]; other site 637887001788 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001789 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887001790 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 637887001791 dimerization interface [polypeptide binding]; other site 637887001792 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 637887001793 ATP binding site [chemical binding]; other site 637887001794 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 637887001795 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 637887001796 HupF/HypC family; Region: HupF_HypC; pfam01455 637887001797 Acylphosphatase; Region: Acylphosphatase; pfam00708 637887001798 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 637887001799 HypF finger; Region: zf-HYPF; pfam07503 637887001800 HypF finger; Region: zf-HYPF; pfam07503 637887001801 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 637887001802 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 637887001803 G1 box; other site 637887001804 GTP/Mg2+ binding site [chemical binding]; other site 637887001805 G2 box; other site 637887001806 Switch I region; other site 637887001807 G3 box; other site 637887001808 Switch II region; other site 637887001809 G4 box; other site 637887001810 G5 box; other site 637887001811 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 637887001812 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 637887001813 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 637887001814 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887001815 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 637887001816 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 637887001817 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 637887001818 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 637887001819 NADH dehydrogenase; Region: NADHdh; cl00469 637887001820 hydrogenase 4 subunit D; Validated; Region: PRK06525 637887001821 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637887001822 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 637887001823 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637887001824 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 637887001825 dimer interface [polypeptide binding]; other site 637887001826 Citrate synthase; Region: Citrate_synt; pfam00285 637887001827 active site 637887001828 citrylCoA binding site [chemical binding]; other site 637887001829 oxalacetate/citrate binding site [chemical binding]; other site 637887001830 coenzyme A binding site [chemical binding]; other site 637887001831 catalytic triad [active] 637887001832 histidine decarboxylase; Provisional; Region: PRK02769 637887001833 L-tyrosine decarboxylase; Provisional; Region: PRK13520 637887001834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637887001835 catalytic residue [active] 637887001836 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 637887001837 putative CheA interaction surface; other site 637887001838 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 637887001839 Cache domain; Region: Cache_1; pfam02743 637887001840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887001841 dimerization interface [polypeptide binding]; other site 637887001842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887001843 dimerization interface [polypeptide binding]; other site 637887001844 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887001845 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887001846 dimer interface [polypeptide binding]; other site 637887001847 putative CheW interface [polypeptide binding]; other site 637887001848 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 637887001849 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 637887001850 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 637887001851 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 637887001852 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 637887001853 putative ligand binding site [chemical binding]; other site 637887001854 putative NAD binding site [chemical binding]; other site 637887001855 putative catalytic site [active] 637887001856 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 637887001857 L-serine binding site [chemical binding]; other site 637887001858 ACT domain interface; other site 637887001859 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 637887001860 HAMP domain; Region: HAMP; pfam00672 637887001861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887001862 dimer interface [polypeptide binding]; other site 637887001863 putative CheW interface [polypeptide binding]; other site 637887001864 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 637887001865 FMN binding site [chemical binding]; other site 637887001866 dimer interface [polypeptide binding]; other site 637887001867 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887001868 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 637887001869 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637887001870 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 637887001871 Ferritin-like domain; Region: Ferritin; pfam00210 637887001872 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 637887001873 dinuclear metal binding motif [ion binding]; other site 637887001874 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 637887001875 UbiA prenyltransferase family; Region: UbiA; pfam01040 637887001876 Rhomboid family; Region: Rhomboid; cl11446 637887001877 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637887001878 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637887001879 Protein of unknown function (DUF975); Region: DUF975; cl10504 637887001880 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 637887001881 phosphopeptide binding site; other site 637887001882 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 637887001883 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637887001884 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637887001885 hypothetical protein; Reviewed; Region: PRK00024 637887001886 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637887001887 MPN+ (JAMM) motif; other site 637887001888 Zinc-binding site [ion binding]; other site 637887001889 TPR repeat; Region: TPR_11; pfam13414 637887001890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887001891 binding surface 637887001892 TPR motif; other site 637887001893 TPR repeat; Region: TPR_11; pfam13414 637887001894 TPR repeat; Region: TPR_11; pfam13414 637887001895 TPR repeat; Region: TPR_11; pfam13414 637887001896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887001897 binding surface 637887001898 TPR motif; other site 637887001899 TPR repeat; Region: TPR_11; pfam13414 637887001900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887001901 binding surface 637887001902 TPR motif; other site 637887001903 TPR repeat; Region: TPR_11; pfam13414 637887001904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887001905 binding surface 637887001906 TPR repeat; Region: TPR_11; pfam13414 637887001907 TPR motif; other site 637887001908 TPR repeat; Region: TPR_11; pfam13414 637887001909 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887001910 Interdomain contacts; other site 637887001911 Cytokine receptor motif; other site 637887001912 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 637887001913 Interdomain contacts; other site 637887001914 Cytokine receptor motif; other site 637887001915 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887001916 Interdomain contacts; other site 637887001917 Cytokine receptor motif; other site 637887001918 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887001919 MULE transposase domain; Region: MULE; pfam10551 637887001920 Kelch domain; Region: Kelch; smart00612 637887001921 Kelch motif; Region: Kelch_1; pfam01344 637887001922 Kelch motif; Region: Kelch_1; pfam01344 637887001923 Kelch motif; Region: Kelch_1; pfam01344 637887001924 Kelch domain; Region: Kelch; smart00612 637887001925 RHS Repeat; Region: RHS_repeat; pfam05593 637887001926 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887001927 RHS Repeat; Region: RHS_repeat; pfam05593 637887001928 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 637887001929 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637887001930 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 637887001931 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 637887001932 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 637887001933 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 637887001934 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 637887001935 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637887001936 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 637887001937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887001938 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 637887001939 Walker A/P-loop; other site 637887001940 ATP binding site [chemical binding]; other site 637887001941 Q-loop/lid; other site 637887001942 ABC transporter signature motif; other site 637887001943 Walker B; other site 637887001944 D-loop; other site 637887001945 H-loop/switch region; other site 637887001946 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 637887001947 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 637887001948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887001949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887001950 dimerization interface [polypeptide binding]; other site 637887001951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887001952 dimer interface [polypeptide binding]; other site 637887001953 phosphorylation site [posttranslational modification] 637887001954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887001955 ATP binding site [chemical binding]; other site 637887001956 Mg2+ binding site [ion binding]; other site 637887001957 G-X-G motif; other site 637887001958 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887001959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887001960 active site 637887001961 phosphorylation site [posttranslational modification] 637887001962 intermolecular recognition site; other site 637887001963 dimerization interface [polypeptide binding]; other site 637887001964 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887001965 DNA binding site [nucleotide binding] 637887001966 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 637887001967 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 637887001968 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 637887001969 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 637887001970 active site 637887001971 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637887001972 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637887001973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887001974 motif II; other site 637887001975 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637887001976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887001977 active site 637887001978 motif I; other site 637887001979 motif II; other site 637887001980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887001981 motif II; other site 637887001982 von Willebrand factor; Region: vWF_A; pfam12450 637887001983 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 637887001984 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 637887001985 metal ion-dependent adhesion site (MIDAS); other site 637887001986 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 637887001987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887001988 FeS/SAM binding site; other site 637887001989 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637887001990 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887001991 dockerin binding interface; other site 637887001992 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887001993 dockerin binding interface; other site 637887001994 Cellulose binding domain; Region: CBM_3; pfam00942 637887001995 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887001996 dockerin binding interface; other site 637887001997 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887001998 dockerin binding interface; other site 637887001999 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887002000 dockerin binding interface; other site 637887002001 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887002002 dockerin binding interface; other site 637887002003 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887002004 dockerin binding interface; other site 637887002005 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887002006 dockerin binding interface; other site 637887002007 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887002008 dockerin binding interface; other site 637887002009 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887002010 dockerin binding interface; other site 637887002011 S-layer homology domain; Region: SLH; pfam00395 637887002012 S-layer homology domain; Region: SLH; pfam00395 637887002013 S-layer homology domain; Region: SLH; pfam00395 637887002014 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887002015 dockerin binding interface; other site 637887002016 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887002017 dockerin binding interface; other site 637887002018 S-layer homology domain; Region: SLH; pfam00395 637887002019 S-layer homology domain; Region: SLH; pfam00395 637887002020 S-layer homology domain; Region: SLH; pfam00395 637887002021 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887002022 dockerin binding interface; other site 637887002023 S-layer homology domain; Region: SLH; pfam00395 637887002024 S-layer homology domain; Region: SLH; pfam00395 637887002025 S-layer homology domain; Region: SLH; pfam00395 637887002026 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 637887002027 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 637887002028 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 637887002029 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 637887002030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637887002031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887002032 S-adenosylmethionine binding site [chemical binding]; other site 637887002033 Response regulator receiver domain; Region: Response_reg; pfam00072 637887002034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002035 active site 637887002036 phosphorylation site [posttranslational modification] 637887002037 intermolecular recognition site; other site 637887002038 dimerization interface [polypeptide binding]; other site 637887002039 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 637887002040 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 637887002041 hinge; other site 637887002042 active site 637887002043 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 637887002044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002045 active site 637887002046 phosphorylation site [posttranslational modification] 637887002047 intermolecular recognition site; other site 637887002048 dimerization interface [polypeptide binding]; other site 637887002049 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 637887002050 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 637887002051 IHF - DNA interface [nucleotide binding]; other site 637887002052 IHF dimer interface [polypeptide binding]; other site 637887002053 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 637887002054 Ligand Binding Site [chemical binding]; other site 637887002055 fumarate hydratase; Provisional; Region: PRK06246 637887002056 Fumarase C-terminus; Region: Fumerase_C; cl00795 637887002057 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 637887002058 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 637887002059 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 637887002060 GDP-binding site [chemical binding]; other site 637887002061 ACT binding site; other site 637887002062 IMP binding site; other site 637887002063 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887002064 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 637887002065 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 637887002066 Ligand binding site; other site 637887002067 Putative Catalytic site; other site 637887002068 DXD motif; other site 637887002069 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 637887002070 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 637887002071 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 637887002072 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 637887002073 Ligand binding site; other site 637887002074 Putative Catalytic site; other site 637887002075 DXD motif; other site 637887002076 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 637887002077 Ligand binding site; other site 637887002078 Putative Catalytic site; other site 637887002079 DXD motif; other site 637887002080 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 637887002081 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 637887002082 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 637887002083 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 637887002084 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887002085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887002086 homodimer interface [polypeptide binding]; other site 637887002087 catalytic residue [active] 637887002088 Transcriptional regulator [Transcription]; Region: LytR; COG1316 637887002089 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 637887002090 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 637887002091 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 637887002092 Ligand Binding Site [chemical binding]; other site 637887002093 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 637887002094 active site 637887002095 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 637887002096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887002097 FeS/SAM binding site; other site 637887002098 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 637887002099 Fe-S cluster binding site [ion binding]; other site 637887002100 active site 637887002101 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 637887002102 active site 637887002103 Fe-S cluster binding site [ion binding]; other site 637887002104 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 637887002105 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 637887002106 putative ATP binding site [chemical binding]; other site 637887002107 putative substrate interface [chemical binding]; other site 637887002108 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887002109 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 637887002110 Domain of unknown function (DUF377); Region: DUF377; pfam04041 637887002111 active site 637887002112 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 637887002113 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 637887002114 active site 637887002115 Substrate binding site; other site 637887002116 Mg++ binding site; other site 637887002117 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637887002118 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 637887002119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887002120 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 637887002121 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 637887002122 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 637887002123 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 637887002124 Hemerythrin; Region: Hemerythrin; cd12107 637887002125 Fe binding site [ion binding]; other site 637887002126 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 637887002127 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 637887002128 Rubredoxin; Region: Rubredoxin; pfam00301 637887002129 iron binding site [ion binding]; other site 637887002130 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 637887002131 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637887002132 dimer interface [polypeptide binding]; other site 637887002133 PYR/PP interface [polypeptide binding]; other site 637887002134 TPP binding site [chemical binding]; other site 637887002135 substrate binding site [chemical binding]; other site 637887002136 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 637887002137 Domain of unknown function; Region: EKR; smart00890 637887002138 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887002139 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 637887002140 TPP-binding site [chemical binding]; other site 637887002141 dimer interface [polypeptide binding]; other site 637887002142 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 637887002143 potential frameshift: common BLAST hit: gi|125975601|ref|YP_001039511.1| von Willebrand factor, type A 637887002144 S-layer homology domain; Region: SLH; pfam00395 637887002145 S-layer homology domain; Region: SLH; pfam00395 637887002146 S-layer homology domain; Region: SLH; pfam00395 637887002147 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 637887002148 von Willebrand factor type A domain; Region: VWA_2; pfam13519 637887002149 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887002150 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887002151 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 637887002152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637887002153 acyl-activating enzyme (AAE) consensus motif; other site 637887002154 AMP binding site [chemical binding]; other site 637887002155 active site 637887002156 CoA binding site [chemical binding]; other site 637887002157 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 637887002158 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637887002159 putative dimer interface [polypeptide binding]; other site 637887002160 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 637887002161 nudix motif; other site 637887002162 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 637887002163 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637887002164 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637887002165 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 637887002166 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 637887002167 transmembrane helices; other site 637887002168 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637887002169 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 637887002170 metal ion-dependent adhesion site (MIDAS); other site 637887002171 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 637887002172 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887002173 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887002174 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 637887002175 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 637887002176 TAP-like protein; Region: Abhydrolase_4; pfam08386 637887002177 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 637887002178 catalytic triad [active] 637887002179 putative active site [active] 637887002180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637887002181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637887002182 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 637887002183 active site 637887002184 catalytic triad [active] 637887002185 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887002186 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 637887002187 Ca binding site [ion binding]; other site 637887002188 Ca binding site (active) [ion binding]; other site 637887002189 ligand binding site [chemical binding]; other site 637887002190 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 637887002191 active site 637887002192 catalytic triad [active] 637887002193 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 637887002194 Penicillinase repressor; Region: Pencillinase_R; cl17580 637887002195 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 637887002196 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637887002197 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887002198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887002199 Walker A/P-loop; other site 637887002200 ATP binding site [chemical binding]; other site 637887002201 Q-loop/lid; other site 637887002202 ABC transporter signature motif; other site 637887002203 Walker B; other site 637887002204 D-loop; other site 637887002205 H-loop/switch region; other site 637887002206 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637887002207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887002208 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637887002209 Walker A/P-loop; other site 637887002210 ATP binding site [chemical binding]; other site 637887002211 Q-loop/lid; other site 637887002212 ABC transporter signature motif; other site 637887002213 Walker B; other site 637887002214 D-loop; other site 637887002215 H-loop/switch region; other site 637887002216 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 637887002217 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 637887002218 metal binding site [ion binding]; metal-binding site 637887002219 dimer interface [polypeptide binding]; other site 637887002220 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 637887002221 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 637887002222 homotrimer interface [polypeptide binding]; other site 637887002223 Walker A motif; other site 637887002224 GTP binding site [chemical binding]; other site 637887002225 Walker B motif; other site 637887002226 cobalamin synthase; Reviewed; Region: cobS; PRK00235 637887002227 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637887002228 catalytic core [active] 637887002229 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 637887002230 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 637887002231 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 637887002232 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887002233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887002234 dimer interface [polypeptide binding]; other site 637887002235 putative CheW interface [polypeptide binding]; other site 637887002236 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 637887002237 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 637887002238 active site 637887002239 catalytic residues [active] 637887002240 metal binding site [ion binding]; metal-binding site 637887002241 aconitate hydratase; Validated; Region: PRK07229 637887002242 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 637887002243 substrate binding site [chemical binding]; other site 637887002244 ligand binding site [chemical binding]; other site 637887002245 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 637887002246 substrate binding site [chemical binding]; other site 637887002247 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637887002248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637887002249 DNA-binding site [nucleotide binding]; DNA binding site 637887002250 FCD domain; Region: FCD; pfam07729 637887002251 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 637887002252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887002253 S-adenosylmethionine binding site [chemical binding]; other site 637887002254 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 637887002255 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637887002256 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637887002257 RNA binding surface [nucleotide binding]; other site 637887002258 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 637887002259 active site 637887002260 uracil binding [chemical binding]; other site 637887002261 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637887002262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887002263 S-adenosylmethionine binding site [chemical binding]; other site 637887002264 Carbohydrate binding domain; Region: CBM_25; smart01066 637887002265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002266 active site 637887002267 phosphorylation site [posttranslational modification] 637887002268 intermolecular recognition site; other site 637887002269 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637887002270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887002271 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 637887002272 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 637887002273 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 637887002274 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 637887002275 ligand binding site; other site 637887002276 oligomer interface; other site 637887002277 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 637887002278 dimer interface [polypeptide binding]; other site 637887002279 N-terminal domain interface [polypeptide binding]; other site 637887002280 sulfate 1 binding site; other site 637887002281 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 637887002282 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 637887002283 ligand binding site; other site 637887002284 oligomer interface; other site 637887002285 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 637887002286 dimer interface [polypeptide binding]; other site 637887002287 N-terminal domain interface [polypeptide binding]; other site 637887002288 sulfate 1 binding site; other site 637887002289 putative lipid kinase; Reviewed; Region: PRK13059 637887002290 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 637887002291 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 637887002292 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 637887002293 NAD binding site [chemical binding]; other site 637887002294 homotetramer interface [polypeptide binding]; other site 637887002295 homodimer interface [polypeptide binding]; other site 637887002296 substrate binding site [chemical binding]; other site 637887002297 active site 637887002298 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887002299 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887002300 Walker A/P-loop; other site 637887002301 ATP binding site [chemical binding]; other site 637887002302 Q-loop/lid; other site 637887002303 ABC transporter signature motif; other site 637887002304 Walker B; other site 637887002305 D-loop; other site 637887002306 H-loop/switch region; other site 637887002307 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 637887002308 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 637887002309 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637887002310 FtsX-like permease family; Region: FtsX; pfam02687 637887002311 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 637887002312 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637887002313 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637887002314 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 637887002315 Predicted membrane protein [Function unknown]; Region: COG2323 637887002316 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637887002317 monogalactosyldiacylglycerol synthase; Region: PLN02605 637887002318 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 637887002319 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 637887002320 Protein of unknown function (DUF342); Region: DUF342; pfam03961 637887002321 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637887002322 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637887002323 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637887002324 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 637887002325 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 637887002326 TrkA-N domain; Region: TrkA_N; pfam02254 637887002327 TrkA-C domain; Region: TrkA_C; pfam02080 637887002328 TrkA-N domain; Region: TrkA_N; pfam02254 637887002329 TrkA-C domain; Region: TrkA_C; pfam02080 637887002330 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 637887002331 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637887002332 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 637887002333 Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702 637887002334 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 637887002335 Radical SAM superfamily; Region: Radical_SAM; pfam04055 637887002336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887002337 FeS/SAM binding site; other site 637887002338 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 637887002339 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 637887002340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887002341 ATP binding site [chemical binding]; other site 637887002342 Mg2+ binding site [ion binding]; other site 637887002343 G-X-G motif; other site 637887002344 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887002345 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 637887002346 AAA domain; Region: AAA_30; pfam13604 637887002347 Family description; Region: UvrD_C_2; pfam13538 637887002348 AAA domain; Region: AAA_31; pfam13614 637887002349 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637887002350 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 637887002351 Zn binding site [ion binding]; other site 637887002352 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 637887002353 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 637887002354 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 637887002355 PRC-barrel domain; Region: PRC; pfam05239 637887002356 PRC-barrel domain; Region: PRC; pfam05239 637887002357 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637887002358 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637887002359 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 637887002360 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 637887002361 motif 1; other site 637887002362 active site 637887002363 motif 2; other site 637887002364 motif 3; other site 637887002365 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 637887002366 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 637887002367 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 637887002368 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 637887002369 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 637887002370 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 637887002371 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 637887002372 CRISPR-associated protein; Region: TIGR03986 637887002373 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 637887002374 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747 637887002375 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 637887002376 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 637887002377 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887002378 MULE transposase domain; Region: MULE; pfam10551 637887002379 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 637887002380 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 637887002381 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 637887002382 Transposase; Region: HTH_Tnp_1; pfam01527 637887002383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887002384 HTH-like domain; Region: HTH_21; pfam13276 637887002385 Integrase core domain; Region: rve; pfam00665 637887002386 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887002387 Integrase core domain; Region: rve_3; pfam13683 637887002388 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887002389 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887002390 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887002391 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 637887002392 RHS Repeat; Region: RHS_repeat; pfam05593 637887002393 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002394 RHS Repeat; Region: RHS_repeat; cl11982 637887002395 RHS Repeat; Region: RHS_repeat; pfam05593 637887002396 RHS Repeat; Region: RHS_repeat; pfam05593 637887002397 RHS Repeat; Region: RHS_repeat; pfam05593 637887002398 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002399 RHS Repeat; Region: RHS_repeat; pfam05593 637887002400 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637887002401 RHS Repeat; Region: RHS_repeat; pfam05593 637887002402 RHS Repeat; Region: RHS_repeat; pfam05593 637887002403 RHS Repeat; Region: RHS_repeat; pfam05593 637887002404 RHS Repeat; Region: RHS_repeat; pfam05593 637887002405 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637887002406 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637887002407 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 637887002408 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637887002409 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887002410 MULE transposase domain; Region: MULE; pfam10551 637887002411 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 637887002412 RHS Repeat; Region: RHS_repeat; pfam05593 637887002413 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002414 RHS Repeat; Region: RHS_repeat; cl11982 637887002415 RHS Repeat; Region: RHS_repeat; pfam05593 637887002416 RHS Repeat; Region: RHS_repeat; cl11982 637887002417 RHS Repeat; Region: RHS_repeat; pfam05593 637887002418 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002419 RHS Repeat; Region: RHS_repeat; pfam05593 637887002420 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637887002421 RHS Repeat; Region: RHS_repeat; pfam05593 637887002422 RHS Repeat; Region: RHS_repeat; pfam05593 637887002423 RHS Repeat; Region: RHS_repeat; pfam05593 637887002424 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637887002425 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887002426 MULE transposase domain; Region: MULE; pfam10551 637887002427 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637887002428 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 637887002429 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 637887002430 [2Fe-2S] cluster binding site [ion binding]; other site 637887002431 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637887002432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887002433 substrate binding pocket [chemical binding]; other site 637887002434 membrane-bound complex binding site; other site 637887002435 hinge residues; other site 637887002436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887002437 dimer interface [polypeptide binding]; other site 637887002438 conserved gate region; other site 637887002439 putative PBP binding loops; other site 637887002440 ABC-ATPase subunit interface; other site 637887002441 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637887002442 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637887002443 Walker A/P-loop; other site 637887002444 ATP binding site [chemical binding]; other site 637887002445 Q-loop/lid; other site 637887002446 ABC transporter signature motif; other site 637887002447 Walker B; other site 637887002448 D-loop; other site 637887002449 H-loop/switch region; other site 637887002450 A new structural DNA glycosylase; Region: AlkD_like; cd06561 637887002451 active site 637887002452 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 637887002453 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887002454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637887002455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887002456 Coenzyme A binding pocket [chemical binding]; other site 637887002457 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637887002458 MarR family; Region: MarR_2; pfam12802 637887002459 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 637887002460 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 637887002461 TIR domain; Region: TIR_2; pfam13676 637887002462 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 637887002463 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637887002464 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 637887002465 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 637887002466 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 637887002467 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637887002468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887002469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887002470 DNA binding residues [nucleotide binding] 637887002471 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 637887002472 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 637887002473 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637887002474 catalytic core [active] 637887002475 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 637887002476 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 637887002477 NADP binding site [chemical binding]; other site 637887002478 homodimer interface [polypeptide binding]; other site 637887002479 active site 637887002480 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887002481 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 637887002482 putative active site [active] 637887002483 putative metal binding site [ion binding]; other site 637887002484 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 637887002485 beta-galactosidase; Region: BGL; TIGR03356 637887002486 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 637887002487 AzlC protein; Region: AzlC; pfam03591 637887002488 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 637887002489 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 637887002490 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637887002491 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637887002492 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887002493 RDD family; Region: RDD; pfam06271 637887002494 Domain of unknown function (DUF718); Region: DUF718; cl01281 637887002495 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 637887002496 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 637887002497 tandem repeat interface [polypeptide binding]; other site 637887002498 oligomer interface [polypeptide binding]; other site 637887002499 active site residues [active] 637887002500 Predicted membrane protein [Function unknown]; Region: COG1971 637887002501 Domain of unknown function DUF; Region: DUF204; pfam02659 637887002502 Domain of unknown function DUF; Region: DUF204; pfam02659 637887002503 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637887002504 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 637887002505 Walker A/P-loop; other site 637887002506 ATP binding site [chemical binding]; other site 637887002507 Q-loop/lid; other site 637887002508 ABC transporter signature motif; other site 637887002509 Walker B; other site 637887002510 D-loop; other site 637887002511 H-loop/switch region; other site 637887002512 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 637887002513 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 637887002514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887002515 catalytic residue [active] 637887002516 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 637887002517 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 637887002518 substrate binding site [chemical binding]; other site 637887002519 active site 637887002520 catalytic residues [active] 637887002521 heterodimer interface [polypeptide binding]; other site 637887002522 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637887002523 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 637887002524 potential frameshift: common BLAST hit: gi|125973923|ref|YP_001037833.1| periplasmic sensor signal transduction histidine kinase 637887002525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887002526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887002527 dimerization interface [polypeptide binding]; other site 637887002528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887002529 dimer interface [polypeptide binding]; other site 637887002530 phosphorylation site [posttranslational modification] 637887002531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887002532 ATP binding site [chemical binding]; other site 637887002533 Mg2+ binding site [ion binding]; other site 637887002534 G-X-G motif; other site 637887002535 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887002536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002537 active site 637887002538 phosphorylation site [posttranslational modification] 637887002539 intermolecular recognition site; other site 637887002540 dimerization interface [polypeptide binding]; other site 637887002541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887002542 DNA binding site [nucleotide binding] 637887002543 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 637887002544 putative metal binding residues [ion binding]; other site 637887002545 signature motif; other site 637887002546 dimer interface [polypeptide binding]; other site 637887002547 active site 637887002548 polyP binding site; other site 637887002549 substrate binding site [chemical binding]; other site 637887002550 acceptor-phosphate pocket; other site 637887002551 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 637887002552 MgtC family; Region: MgtC; pfam02308 637887002553 CotH protein; Region: CotH; pfam08757 637887002554 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 637887002555 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 637887002556 G1 box; other site 637887002557 GTP/Mg2+ binding site [chemical binding]; other site 637887002558 Switch I region; other site 637887002559 G2 box; other site 637887002560 G3 box; other site 637887002561 Switch II region; other site 637887002562 G4 box; other site 637887002563 G5 box; other site 637887002564 Nucleoside recognition; Region: Gate; pfam07670 637887002565 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 637887002566 Nucleoside recognition; Region: Gate; pfam07670 637887002567 FeoA domain; Region: FeoA; pfam04023 637887002568 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 637887002569 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 637887002570 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 637887002571 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 637887002572 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887002573 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887002574 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 637887002575 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887002576 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887002577 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 637887002578 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 637887002579 Ligand binding site; other site 637887002580 metal-binding site 637887002581 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 637887002582 PLD-like domain; Region: PLDc_2; pfam13091 637887002583 putative active site [active] 637887002584 catalytic site [active] 637887002585 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 637887002586 PLD-like domain; Region: PLDc_2; pfam13091 637887002587 putative active site [active] 637887002588 catalytic site [active] 637887002589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887002590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002591 active site 637887002592 phosphorylation site [posttranslational modification] 637887002593 intermolecular recognition site; other site 637887002594 dimerization interface [polypeptide binding]; other site 637887002595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887002596 DNA binding site [nucleotide binding] 637887002597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887002598 dimerization interface [polypeptide binding]; other site 637887002599 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 637887002600 CHASE4 domain; Region: CHASE4; cl01308 637887002601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887002602 dimer interface [polypeptide binding]; other site 637887002603 phosphorylation site [posttranslational modification] 637887002604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887002605 ATP binding site [chemical binding]; other site 637887002606 Mg2+ binding site [ion binding]; other site 637887002607 G-X-G motif; other site 637887002608 2-isopropylmalate synthase; Validated; Region: PRK00915 637887002609 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 637887002610 active site 637887002611 catalytic residues [active] 637887002612 metal binding site [ion binding]; metal-binding site 637887002613 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 637887002614 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637887002615 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637887002616 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637887002617 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 637887002618 active site 637887002619 NTP binding site [chemical binding]; other site 637887002620 metal binding triad [ion binding]; metal-binding site 637887002621 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637887002622 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887002623 Zn2+ binding site [ion binding]; other site 637887002624 Mg2+ binding site [ion binding]; other site 637887002625 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 637887002626 Trp repressor protein; Region: Trp_repressor; cl17266 637887002627 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 637887002628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887002629 ATP binding site [chemical binding]; other site 637887002630 putative Mg++ binding site [ion binding]; other site 637887002631 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 637887002632 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 637887002633 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 637887002634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887002635 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637887002636 TPR repeat; Region: TPR_11; pfam13414 637887002637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887002638 binding surface 637887002639 TPR motif; other site 637887002640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887002641 Tetratricopeptide repeat; Region: TPR_16; pfam13432 637887002642 binding surface 637887002643 TPR motif; other site 637887002644 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 637887002645 nucleophile elbow; other site 637887002646 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 637887002647 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 637887002648 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 637887002649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887002650 catalytic residue [active] 637887002651 Response regulator receiver domain; Region: Response_reg; pfam00072 637887002652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002653 active site 637887002654 phosphorylation site [posttranslational modification] 637887002655 intermolecular recognition site; other site 637887002656 dimerization interface [polypeptide binding]; other site 637887002657 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637887002658 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637887002659 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637887002660 Response regulator receiver domain; Region: Response_reg; pfam00072 637887002661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002662 active site 637887002663 phosphorylation site [posttranslational modification] 637887002664 intermolecular recognition site; other site 637887002665 dimerization interface [polypeptide binding]; other site 637887002666 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887002667 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887002668 Zn2+ binding site [ion binding]; other site 637887002669 Mg2+ binding site [ion binding]; other site 637887002670 hypothetical protein; Provisional; Region: PRK04435 637887002671 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637887002672 homoserine dehydrogenase; Provisional; Region: PRK06349 637887002673 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 637887002674 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637887002675 aspartate kinase; Reviewed; Region: PRK09034 637887002676 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 637887002677 putative catalytic residues [active] 637887002678 putative nucleotide binding site [chemical binding]; other site 637887002679 putative aspartate binding site [chemical binding]; other site 637887002680 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 637887002681 allosteric regulatory residue; other site 637887002682 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 637887002683 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887002684 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 637887002685 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002686 RHS Repeat; Region: RHS_repeat; pfam05593 637887002687 RHS Repeat; Region: RHS_repeat; pfam05593 637887002688 RHS Repeat; Region: RHS_repeat; pfam05593 637887002689 RHS Repeat; Region: RHS_repeat; pfam05593 637887002690 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002691 RHS Repeat; Region: RHS_repeat; pfam05593 637887002692 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637887002693 RHS Repeat; Region: RHS_repeat; pfam05593 637887002694 RHS Repeat; Region: RHS_repeat; cl11982 637887002695 RHS Repeat; Region: RHS_repeat; pfam05593 637887002696 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637887002697 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 637887002698 RHS Repeat; Region: RHS_repeat; cl11982 637887002699 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002700 RHS Repeat; Region: RHS_repeat; pfam05593 637887002701 RHS Repeat; Region: RHS_repeat; cl11982 637887002702 RHS Repeat; Region: RHS_repeat; cl11982 637887002703 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637887002704 RHS Repeat; Region: RHS_repeat; pfam05593 637887002705 RHS Repeat; Region: RHS_repeat; pfam05593 637887002706 RHS Repeat; Region: RHS_repeat; pfam05593 637887002707 RHS Repeat; Region: RHS_repeat; pfam05593 637887002708 RHS Repeat; Region: RHS_repeat; pfam05593 637887002709 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637887002710 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 637887002711 nucleotide binding site/active site [active] 637887002712 HIT family signature motif; other site 637887002713 catalytic residue [active] 637887002714 S-layer homology domain; Region: SLH; pfam00395 637887002715 S-layer homology domain; Region: SLH; pfam00395 637887002716 S-layer homology domain; Region: SLH; pfam00395 637887002717 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887002718 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 637887002719 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 637887002720 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 637887002721 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 637887002722 active site 637887002723 catalytic triad [active] 637887002724 oxyanion hole [active] 637887002725 Chain length determinant protein; Region: Wzz; cl15801 637887002726 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 637887002727 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 637887002728 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637887002729 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 637887002730 Transcription antiterminator [Transcription]; Region: NusG; COG0250 637887002731 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 637887002732 heterodimer interface [polypeptide binding]; other site 637887002733 homodimer interface [polypeptide binding]; other site 637887002734 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637887002735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637887002736 NAD(P) binding site [chemical binding]; other site 637887002737 active site 637887002738 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 637887002739 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 637887002740 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 637887002741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887002742 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 637887002743 putative ADP-binding pocket [chemical binding]; other site 637887002744 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 637887002745 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637887002746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637887002747 active site 637887002748 O-Antigen ligase; Region: Wzy_C; pfam04932 637887002749 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637887002750 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 637887002751 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 637887002752 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 637887002753 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637887002754 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 637887002755 Predicted integral membrane protein [Function unknown]; Region: COG5652 637887002756 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 637887002757 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637887002758 dimer interface [polypeptide binding]; other site 637887002759 ssDNA binding site [nucleotide binding]; other site 637887002760 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637887002761 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 637887002762 Bacterial sugar transferase; Region: Bac_transf; pfam02397 637887002763 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 637887002764 Yqey-like protein; Region: YqeY; pfam09424 637887002765 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 637887002766 DHH family; Region: DHH; pfam01368 637887002767 DHHA1 domain; Region: DHHA1; pfam02272 637887002768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887002769 active site 637887002770 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 637887002771 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887002772 Zn2+ binding site [ion binding]; other site 637887002773 Mg2+ binding site [ion binding]; other site 637887002774 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637887002775 synthetase active site [active] 637887002776 NTP binding site [chemical binding]; other site 637887002777 metal binding site [ion binding]; metal-binding site 637887002778 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 637887002779 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637887002780 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 637887002781 putative active site [active] 637887002782 dimerization interface [polypeptide binding]; other site 637887002783 putative tRNAtyr binding site [nucleotide binding]; other site 637887002784 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 637887002785 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 637887002786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887002787 FeS/SAM binding site; other site 637887002788 AAA domain; Region: AAA_31; pfam13614 637887002789 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 637887002790 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 637887002791 ATP binding site [chemical binding]; other site 637887002792 Walker A motif; other site 637887002793 hexamer interface [polypeptide binding]; other site 637887002794 Walker B motif; other site 637887002795 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 637887002796 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 637887002797 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637887002798 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 637887002799 TadE-like protein; Region: TadE; pfam07811 637887002800 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637887002801 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 637887002802 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 637887002803 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 637887002804 phosphopeptide binding site; other site 637887002805 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 637887002806 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 637887002807 dimer interface [polypeptide binding]; other site 637887002808 motif 1; other site 637887002809 active site 637887002810 motif 2; other site 637887002811 motif 3; other site 637887002812 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 637887002813 anticodon binding site; other site 637887002814 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 637887002815 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 637887002816 dimer interface [polypeptide binding]; other site 637887002817 anticodon binding site; other site 637887002818 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 637887002819 homodimer interface [polypeptide binding]; other site 637887002820 motif 1; other site 637887002821 active site 637887002822 motif 2; other site 637887002823 GAD domain; Region: GAD; pfam02938 637887002824 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 637887002825 motif 3; other site 637887002826 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637887002827 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637887002828 Catalytic site [active] 637887002829 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 637887002830 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 637887002831 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 637887002832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 637887002833 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 637887002834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 637887002835 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 637887002836 stage II sporulation protein P; Region: spore_II_P; TIGR02867 637887002837 GTP-binding protein LepA; Provisional; Region: PRK05433 637887002838 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 637887002839 G1 box; other site 637887002840 putative GEF interaction site [polypeptide binding]; other site 637887002841 GTP/Mg2+ binding site [chemical binding]; other site 637887002842 Switch I region; other site 637887002843 G2 box; other site 637887002844 G3 box; other site 637887002845 Switch II region; other site 637887002846 G4 box; other site 637887002847 G5 box; other site 637887002848 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 637887002849 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 637887002850 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 637887002851 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 637887002852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887002853 FeS/SAM binding site; other site 637887002854 HemN C-terminal domain; Region: HemN_C; pfam06969 637887002855 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 637887002856 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637887002857 DNA binding residues [nucleotide binding] 637887002858 GrpE; Region: GrpE; pfam01025 637887002859 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 637887002860 dimer interface [polypeptide binding]; other site 637887002861 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 637887002862 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 637887002863 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 637887002864 nucleotide binding site [chemical binding]; other site 637887002865 NEF interaction site [polypeptide binding]; other site 637887002866 SBD interface [polypeptide binding]; other site 637887002867 chaperone protein DnaJ; Provisional; Region: PRK14277 637887002868 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637887002869 HSP70 interaction site [polypeptide binding]; other site 637887002870 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 637887002871 substrate binding site [polypeptide binding]; other site 637887002872 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 637887002873 Zn binding sites [ion binding]; other site 637887002874 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 637887002875 dimer interface [polypeptide binding]; other site 637887002876 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 637887002877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887002878 S-adenosylmethionine binding site [chemical binding]; other site 637887002879 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 637887002880 RNA methyltransferase, RsmE family; Region: TIGR00046 637887002881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002882 Response regulator receiver domain; Region: Response_reg; pfam00072 637887002883 active site 637887002884 phosphorylation site [posttranslational modification] 637887002885 intermolecular recognition site; other site 637887002886 dimerization interface [polypeptide binding]; other site 637887002887 hypothetical protein; Provisional; Region: PRK11820 637887002888 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 637887002889 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 637887002890 hypothetical protein; Provisional; Region: PRK04323 637887002891 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 637887002892 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 637887002893 catalytic site [active] 637887002894 G-X2-G-X-G-K; other site 637887002895 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 637887002896 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 637887002897 Flavoprotein; Region: Flavoprotein; pfam02441 637887002898 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 637887002899 glycyl-tRNA synthetase; Provisional; Region: PRK04173 637887002900 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637887002901 motif 1; other site 637887002902 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 637887002903 active site 637887002904 motif 2; other site 637887002905 motif 3; other site 637887002906 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 637887002907 anticodon binding site; other site 637887002908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887002909 ATP binding site [chemical binding]; other site 637887002910 Mg2+ binding site [ion binding]; other site 637887002911 G-X-G motif; other site 637887002912 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 637887002913 Accessory gene regulator B; Region: AgrB; smart00793 637887002914 radical SAM/SPASM domain protein, ACGX system; Region: rSAM_ACGX; TIGR04340 637887002915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887002916 FeS/SAM binding site; other site 637887002917 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 637887002918 pyruvate phosphate dikinase; Provisional; Region: PRK09279 637887002919 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 637887002920 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637887002921 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637887002922 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887002923 dockerin binding interface; other site 637887002924 S-layer homology domain; Region: SLH; pfam00395 637887002925 S-layer homology domain; Region: SLH; pfam00395 637887002926 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 637887002927 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 637887002928 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 637887002929 putative active site [active] 637887002930 PhoH-like protein; Region: PhoH; pfam02562 637887002931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887002932 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637887002933 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637887002934 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887002935 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637887002936 hypothetical protein; Provisional; Region: PRK13670 637887002937 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 637887002938 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 637887002939 5S rRNA interface [nucleotide binding]; other site 637887002940 CTC domain interface [polypeptide binding]; other site 637887002941 L16 interface [polypeptide binding]; other site 637887002942 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 637887002943 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 637887002944 putative dimer interface [polypeptide binding]; other site 637887002945 active site pocket [active] 637887002946 putative cataytic base [active] 637887002947 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 637887002948 Double zinc ribbon; Region: DZR; pfam12773 637887002949 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 637887002950 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 637887002951 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 637887002952 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637887002953 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 637887002954 catalytic residues [active] 637887002955 catalytic nucleophile [active] 637887002956 Recombinase; Region: Recombinase; pfam07508 637887002957 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 637887002958 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887002959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887002960 Zn2+ binding site [ion binding]; other site 637887002961 Mg2+ binding site [ion binding]; other site 637887002962 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 637887002963 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 637887002964 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 637887002965 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 637887002966 active site 637887002967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887002968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887002969 active site 637887002970 phosphorylation site [posttranslational modification] 637887002971 intermolecular recognition site; other site 637887002972 dimerization interface [polypeptide binding]; other site 637887002973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887002974 DNA binding site [nucleotide binding] 637887002975 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637887002976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887002977 dimerization interface [polypeptide binding]; other site 637887002978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887002979 dimer interface [polypeptide binding]; other site 637887002980 phosphorylation site [posttranslational modification] 637887002981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887002982 ATP binding site [chemical binding]; other site 637887002983 Mg2+ binding site [ion binding]; other site 637887002984 G-X-G motif; other site 637887002985 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637887002986 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637887002987 protein binding site [polypeptide binding]; other site 637887002988 GAF domain; Region: GAF_3; pfam13492 637887002989 GAF domain; Region: GAF_2; pfam13185 637887002990 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887002991 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887002992 Zn2+ binding site [ion binding]; other site 637887002993 Mg2+ binding site [ion binding]; other site 637887002994 glycogen synthase; Provisional; Region: glgA; PRK00654 637887002995 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 637887002996 ADP-binding pocket [chemical binding]; other site 637887002997 homodimer interface [polypeptide binding]; other site 637887002998 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 637887002999 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637887003000 minor groove reading motif; other site 637887003001 helix-hairpin-helix signature motif; other site 637887003002 substrate binding pocket [chemical binding]; other site 637887003003 active site 637887003004 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 637887003005 GAF domain; Region: GAF_3; pfam13492 637887003006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887003007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887003008 metal binding site [ion binding]; metal-binding site 637887003009 active site 637887003010 I-site; other site 637887003011 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 637887003012 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 637887003013 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 637887003014 generic binding surface II; other site 637887003015 ssDNA binding site; other site 637887003016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887003017 ATP binding site [chemical binding]; other site 637887003018 putative Mg++ binding site [ion binding]; other site 637887003019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637887003020 nucleotide binding region [chemical binding]; other site 637887003021 ATP-binding site [chemical binding]; other site 637887003022 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 637887003023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887003024 S-adenosylmethionine binding site [chemical binding]; other site 637887003025 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 637887003026 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 637887003027 active site 637887003028 (T/H)XGH motif; other site 637887003029 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 637887003030 Nucleoside recognition; Region: Gate; pfam07670 637887003031 Nucleoside recognition; Region: Gate; pfam07670 637887003032 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887003033 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 637887003034 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887003035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887003036 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 637887003037 substrate binding site [chemical binding]; other site 637887003038 active site 637887003039 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887003040 ligand binding site [chemical binding]; other site 637887003041 metal binding site [ion binding]; metal-binding site 637887003042 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887003043 metal binding site [ion binding]; metal-binding site 637887003044 ligand binding site [chemical binding]; other site 637887003045 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887003046 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887003047 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 637887003048 serpin-like protein; Provisional; Region: PHA02660 637887003049 reactive center loop; other site 637887003050 Domain of unknown function (DUF362); Region: DUF362; pfam04015 637887003051 Uncharacterized conserved protein [Function unknown]; Region: COG2006 637887003052 Sensor protein DegS; Region: DegS; pfam05384 637887003053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637887003054 Histidine kinase; Region: HisKA_3; pfam07730 637887003055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887003056 ATP binding site [chemical binding]; other site 637887003057 Mg2+ binding site [ion binding]; other site 637887003058 G-X-G motif; other site 637887003059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637887003060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887003061 active site 637887003062 phosphorylation site [posttranslational modification] 637887003063 intermolecular recognition site; other site 637887003064 dimerization interface [polypeptide binding]; other site 637887003065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637887003066 DNA binding residues [nucleotide binding] 637887003067 dimerization interface [polypeptide binding]; other site 637887003068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887003069 dimerization interface [polypeptide binding]; other site 637887003070 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887003071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887003072 dimer interface [polypeptide binding]; other site 637887003073 putative CheW interface [polypeptide binding]; other site 637887003074 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 637887003075 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 637887003076 active site 637887003077 substrate binding site [chemical binding]; other site 637887003078 metal binding site [ion binding]; metal-binding site 637887003079 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 637887003080 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 637887003081 active site 637887003082 PHP Thumb interface [polypeptide binding]; other site 637887003083 metal binding site [ion binding]; metal-binding site 637887003084 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 637887003085 generic binding surface II; other site 637887003086 generic binding surface I; other site 637887003087 transcription attenuation protein MtrB; Provisional; Region: PRK13251 637887003088 6-phosphofructokinase; Provisional; Region: PRK03202 637887003089 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 637887003090 active site 637887003091 ADP/pyrophosphate binding site [chemical binding]; other site 637887003092 dimerization interface [polypeptide binding]; other site 637887003093 allosteric effector site; other site 637887003094 fructose-1,6-bisphosphate binding site; other site 637887003095 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 637887003096 active site 637887003097 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637887003098 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887003099 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887003100 Cellulose binding domain; Region: CBM_3; smart01067 637887003101 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887003102 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 637887003103 metal ion-dependent adhesion site (MIDAS); other site 637887003104 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 637887003105 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 637887003106 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 637887003107 YmaF family; Region: YmaF; pfam12788 637887003108 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 637887003109 Predicted permeases [General function prediction only]; Region: COG0679 637887003110 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 637887003111 AIR carboxylase; Region: AIRC; pfam00731 637887003112 amidophosphoribosyltransferase; Provisional; Region: PRK05793 637887003113 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 637887003114 active site 637887003115 tetramer interface [polypeptide binding]; other site 637887003116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887003117 active site 637887003118 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 637887003119 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 637887003120 dimerization interface [polypeptide binding]; other site 637887003121 putative ATP binding site [chemical binding]; other site 637887003122 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 637887003123 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 637887003124 active site 637887003125 substrate binding site [chemical binding]; other site 637887003126 cosubstrate binding site; other site 637887003127 catalytic site [active] 637887003128 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 637887003129 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 637887003130 purine monophosphate binding site [chemical binding]; other site 637887003131 dimer interface [polypeptide binding]; other site 637887003132 putative catalytic residues [active] 637887003133 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 637887003134 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637887003135 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 637887003136 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 637887003137 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 637887003138 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 637887003139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637887003140 active site 637887003141 TPR repeat; Region: TPR_11; pfam13414 637887003142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887003143 binding surface 637887003144 TPR motif; other site 637887003145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637887003146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887003147 Coenzyme A binding pocket [chemical binding]; other site 637887003148 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 637887003149 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 637887003150 active site 637887003151 (T/H)XGH motif; other site 637887003152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887003153 Zn2+ binding site [ion binding]; other site 637887003154 Mg2+ binding site [ion binding]; other site 637887003155 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 637887003156 Oligomerisation domain; Region: Oligomerisation; pfam02410 637887003157 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 637887003158 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637887003159 HIGH motif; other site 637887003160 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637887003161 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637887003162 active site 637887003163 KMSKS motif; other site 637887003164 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 637887003165 tRNA binding surface [nucleotide binding]; other site 637887003166 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003167 Interdomain contacts; other site 637887003168 Cytokine receptor motif; other site 637887003169 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003170 Interdomain contacts; other site 637887003171 Cytokine receptor motif; other site 637887003172 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 637887003173 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003174 Interdomain contacts; other site 637887003175 Cytokine receptor motif; other site 637887003176 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003177 Interdomain contacts; other site 637887003178 Cytokine receptor motif; other site 637887003179 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003180 Interdomain contacts; other site 637887003181 Cytokine receptor motif; other site 637887003182 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003183 Interdomain contacts; other site 637887003184 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003185 Interdomain contacts; other site 637887003186 Cytokine receptor motif; other site 637887003187 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 637887003188 CARDB; Region: CARDB; pfam07705 637887003189 CARDB; Region: CARDB; pfam07705 637887003190 CARDB; Region: CARDB; pfam07705 637887003191 CARDB; Region: CARDB; pfam07705 637887003192 MG2 domain; Region: A2M_N; pfam01835 637887003193 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 637887003194 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 637887003195 CARDB; Region: CARDB; pfam07705 637887003196 CARDB; Region: CARDB; pfam07705 637887003197 CARDB; Region: CARDB; pfam07705 637887003198 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 637887003199 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887003200 Interdomain contacts; other site 637887003201 S-layer homology domain; Region: SLH; pfam00395 637887003202 S-layer homology domain; Region: SLH; pfam00395 637887003203 S-layer homology domain; Region: SLH; pfam00395 637887003204 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887003205 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887003206 dimer interface [polypeptide binding]; other site 637887003207 putative CheW interface [polypeptide binding]; other site 637887003208 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 637887003209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637887003210 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 637887003211 acyl-activating enzyme (AAE) consensus motif; other site 637887003212 acyl-activating enzyme (AAE) consensus motif; other site 637887003213 putative AMP binding site [chemical binding]; other site 637887003214 putative active site [active] 637887003215 putative CoA binding site [chemical binding]; other site 637887003216 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637887003217 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637887003218 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637887003219 SLBB domain; Region: SLBB; pfam10531 637887003220 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 637887003221 Helix-hairpin-helix motif; Region: HHH; pfam00633 637887003222 Sporulation and spore germination; Region: Germane; pfam10646 637887003223 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 637887003224 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 637887003225 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 637887003226 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 637887003227 active site 637887003228 dimer interface [polypeptide binding]; other site 637887003229 motif 1; other site 637887003230 motif 2; other site 637887003231 motif 3; other site 637887003232 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 637887003233 anticodon binding site; other site 637887003234 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 637887003235 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 637887003236 dimerization interface [polypeptide binding]; other site 637887003237 active site 637887003238 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 637887003239 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 637887003240 folate binding site [chemical binding]; other site 637887003241 NADP+ binding site [chemical binding]; other site 637887003242 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 637887003243 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 637887003244 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 637887003245 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 637887003246 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 637887003247 23S rRNA binding site [nucleotide binding]; other site 637887003248 L21 binding site [polypeptide binding]; other site 637887003249 L13 binding site [polypeptide binding]; other site 637887003250 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 637887003251 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 637887003252 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637887003253 Putative glucoamylase; Region: Glycoamylase; pfam10091 637887003254 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 637887003255 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 637887003256 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 637887003257 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 637887003258 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 637887003259 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 637887003260 Clp amino terminal domain; Region: Clp_N; pfam02861 637887003261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887003262 Walker A motif; other site 637887003263 ATP binding site [chemical binding]; other site 637887003264 Walker B motif; other site 637887003265 arginine finger; other site 637887003266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887003267 Walker A motif; other site 637887003268 ATP binding site [chemical binding]; other site 637887003269 Walker B motif; other site 637887003270 arginine finger; other site 637887003271 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637887003272 Uncharacterized conserved protein [Function unknown]; Region: COG2127 637887003273 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637887003274 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637887003275 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 637887003276 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 637887003277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887003278 catalytic residue [active] 637887003279 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637887003280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637887003281 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 637887003282 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 637887003283 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 637887003284 AAA ATPase domain; Region: AAA_16; pfam13191 637887003285 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 637887003286 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 637887003287 metal ion-dependent adhesion site (MIDAS); other site 637887003288 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 637887003289 SpoVR like protein; Region: SpoVR; pfam04293 637887003290 galactoside permease; Reviewed; Region: lacY; PRK09528 637887003291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637887003292 putative substrate translocation pore; other site 637887003293 purine nucleoside phosphorylase; Provisional; Region: PRK08202 637887003294 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 637887003295 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 637887003296 homotetramer interface [polypeptide binding]; other site 637887003297 ligand binding site [chemical binding]; other site 637887003298 catalytic site [active] 637887003299 NAD binding site [chemical binding]; other site 637887003300 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 637887003301 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 637887003302 active site 637887003303 putative substrate binding pocket [chemical binding]; other site 637887003304 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887003305 protein-splicing catalytic site; other site 637887003306 thioester formation/cholesterol transfer; other site 637887003307 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887003308 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 637887003309 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 637887003310 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887003311 MULE transposase domain; Region: MULE; pfam10551 637887003312 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 637887003313 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637887003314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887003315 motif II; other site 637887003316 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 637887003317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887003318 Walker A/P-loop; other site 637887003319 ATP binding site [chemical binding]; other site 637887003320 Q-loop/lid; other site 637887003321 ABC transporter signature motif; other site 637887003322 Walker B; other site 637887003323 D-loop; other site 637887003324 H-loop/switch region; other site 637887003325 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 637887003326 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 637887003327 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 637887003328 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 637887003329 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 637887003330 MoxR-like ATPases [General function prediction only]; Region: COG0714 637887003331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887003332 Walker A motif; other site 637887003333 ATP binding site [chemical binding]; other site 637887003334 Walker B motif; other site 637887003335 arginine finger; other site 637887003336 Protein of unknown function DUF58; Region: DUF58; pfam01882 637887003337 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 637887003338 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 637887003339 Small acid-soluble spore protein H family; Region: SspH; pfam08141 637887003340 Isochorismatase family; Region: Isochorismatase; pfam00857 637887003341 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 637887003342 catalytic triad [active] 637887003343 conserved cis-peptide bond; other site 637887003344 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 637887003345 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 637887003346 active site 637887003347 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 637887003348 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 637887003349 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 637887003350 PilZ domain; Region: PilZ; pfam07238 637887003351 Uncharacterized conserved protein [Function unknown]; Region: COG2006 637887003352 Domain of unknown function (DUF362); Region: DUF362; pfam04015 637887003353 4Fe-4S binding domain; Region: Fer4; pfam00037 637887003354 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637887003355 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637887003356 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637887003357 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 637887003358 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 637887003359 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 637887003360 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 637887003361 hypothetical protein; Provisional; Region: PRK03881 637887003362 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 637887003363 AMMECR1; Region: AMMECR1; pfam01871 637887003364 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 637887003365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887003366 FeS/SAM binding site; other site 637887003367 Uncharacterized conserved protein [Function unknown]; Region: COG1624 637887003368 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 637887003369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 637887003370 YbbR-like protein; Region: YbbR; pfam07949 637887003371 YbbR-like protein; Region: YbbR; pfam07949 637887003372 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 637887003373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637887003374 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 637887003375 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 637887003376 active site 637887003377 substrate binding site [chemical binding]; other site 637887003378 metal binding site [ion binding]; metal-binding site 637887003379 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 637887003380 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 637887003381 glutaminase active site [active] 637887003382 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637887003383 dimer interface [polypeptide binding]; other site 637887003384 active site 637887003385 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637887003386 dimer interface [polypeptide binding]; other site 637887003387 active site 637887003388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637887003389 dimerization interface [polypeptide binding]; other site 637887003390 putative DNA binding site [nucleotide binding]; other site 637887003391 putative Zn2+ binding site [ion binding]; other site 637887003392 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 637887003393 Sodium Bile acid symporter family; Region: SBF; cl17470 637887003394 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 637887003395 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637887003396 active site 637887003397 Predicted permease; Region: DUF318; cl17795 637887003398 Transposase; Region: HTH_Tnp_1; pfam01527 637887003399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887003400 HTH-like domain; Region: HTH_21; pfam13276 637887003401 Integrase core domain; Region: rve; pfam00665 637887003402 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887003403 Integrase core domain; Region: rve_3; pfam13683 637887003404 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 637887003405 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 637887003406 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 637887003407 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 637887003408 Walker A motif; other site 637887003409 ATP binding site [chemical binding]; other site 637887003410 Walker B motif; other site 637887003411 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 637887003412 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637887003413 Walker A motif; other site 637887003414 ATP binding site [chemical binding]; other site 637887003415 Walker B motif; other site 637887003416 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 637887003417 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637887003418 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637887003419 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 637887003420 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 637887003421 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 637887003422 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 637887003423 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 637887003424 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 637887003425 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 637887003426 active site 637887003427 YlzJ-like protein; Region: YlzJ; pfam14035 637887003428 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 637887003429 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 637887003430 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637887003431 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 637887003432 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 637887003433 hypothetical protein; Provisional; Region: PRK00955 637887003434 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 637887003435 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 637887003436 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 637887003437 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 637887003438 homodimer interface [polypeptide binding]; other site 637887003439 NADP binding site [chemical binding]; other site 637887003440 substrate binding site [chemical binding]; other site 637887003441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887003442 ABC transporter signature motif; other site 637887003443 Walker B; other site 637887003444 D-loop; other site 637887003445 H-loop/switch region; other site 637887003446 phosphodiesterase; Provisional; Region: PRK12704 637887003447 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 637887003448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887003449 Zn2+ binding site [ion binding]; other site 637887003450 Mg2+ binding site [ion binding]; other site 637887003451 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 637887003452 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637887003453 putative active site [active] 637887003454 metal binding site [ion binding]; metal-binding site 637887003455 homodimer binding site [polypeptide binding]; other site 637887003456 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 637887003457 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 637887003458 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 637887003459 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 637887003460 NAD binding site [chemical binding]; other site 637887003461 substrate binding site [chemical binding]; other site 637887003462 homodimer interface [polypeptide binding]; other site 637887003463 active site 637887003464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887003465 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637887003466 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 637887003467 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 637887003468 spore coat protein YutH; Region: spore_yutH; TIGR02905 637887003469 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 637887003470 spore coat protein YutH; Region: spore_yutH; TIGR02905 637887003471 amphi-Trp domain; Region: amphi-Trp; TIGR04354 637887003472 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637887003473 Carbohydrate binding domain; Region: CBM_25; smart01066 637887003474 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 637887003475 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 637887003476 active site 637887003477 Substrate binding site; other site 637887003478 Mg++ binding site; other site 637887003479 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637887003480 putative trimer interface [polypeptide binding]; other site 637887003481 putative CoA binding site [chemical binding]; other site 637887003482 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 637887003483 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 637887003484 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 637887003485 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 637887003486 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 637887003487 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 637887003488 NodB motif; other site 637887003489 active site 637887003490 catalytic site [active] 637887003491 Cd binding site [ion binding]; other site 637887003492 YabP family; Region: YabP; cl06766 637887003493 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 637887003494 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 637887003495 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 637887003496 PhoH-like protein; Region: PhoH; pfam02562 637887003497 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 637887003498 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 637887003499 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887003500 Zn2+ binding site [ion binding]; other site 637887003501 Mg2+ binding site [ion binding]; other site 637887003502 metal-binding heat shock protein; Provisional; Region: PRK00016 637887003503 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637887003504 active site 637887003505 catalytic motif [active] 637887003506 Zn binding site [ion binding]; other site 637887003507 GTPase Era; Reviewed; Region: era; PRK00089 637887003508 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 637887003509 G1 box; other site 637887003510 GTP/Mg2+ binding site [chemical binding]; other site 637887003511 Switch I region; other site 637887003512 G2 box; other site 637887003513 Switch II region; other site 637887003514 G3 box; other site 637887003515 G4 box; other site 637887003516 G5 box; other site 637887003517 KH domain; Region: KH_2; pfam07650 637887003518 YqzL-like protein; Region: YqzL; pfam14006 637887003519 Recombination protein O N terminal; Region: RecO_N; pfam11967 637887003520 DNA repair protein RecO; Region: reco; TIGR00613 637887003521 Recombination protein O C terminal; Region: RecO_C; pfam02565 637887003522 PilZ domain; Region: PilZ; pfam07238 637887003523 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 637887003524 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 637887003525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637887003526 catalytic residue [active] 637887003527 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 637887003528 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 637887003529 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 637887003530 Ligand Binding Site [chemical binding]; other site 637887003531 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 637887003532 VanW like protein; Region: VanW; pfam04294 637887003533 G5 domain; Region: G5; pfam07501 637887003534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 637887003535 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 637887003536 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 637887003537 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 637887003538 dimerization interface [polypeptide binding]; other site 637887003539 putative ATP binding site [chemical binding]; other site 637887003540 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 637887003541 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 637887003542 dimer interface [polypeptide binding]; other site 637887003543 active site 637887003544 glycine-pyridoxal phosphate binding site [chemical binding]; other site 637887003545 folate binding site [chemical binding]; other site 637887003546 PspC domain; Region: PspC; pfam04024 637887003547 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 637887003548 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 637887003549 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 637887003550 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 637887003551 Protein of unknown function DUF58; Region: DUF58; pfam01882 637887003552 MoxR-like ATPases [General function prediction only]; Region: COG0714 637887003553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887003554 Walker A motif; other site 637887003555 ATP binding site [chemical binding]; other site 637887003556 Walker B motif; other site 637887003557 arginine finger; other site 637887003558 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 637887003559 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637887003560 NAD binding site [chemical binding]; other site 637887003561 dimer interface [polypeptide binding]; other site 637887003562 substrate binding site [chemical binding]; other site 637887003563 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637887003564 competence damage-inducible protein A; Provisional; Region: PRK00549 637887003565 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 637887003566 putative MPT binding site; other site 637887003567 Competence-damaged protein; Region: CinA; pfam02464 637887003568 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 637887003569 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 637887003570 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 637887003571 recombinase A; Provisional; Region: recA; PRK09354 637887003572 hexamer interface [polypeptide binding]; other site 637887003573 Walker A motif; other site 637887003574 ATP binding site [chemical binding]; other site 637887003575 Walker B motif; other site 637887003576 recombination regulator RecX; Reviewed; Region: recX; PRK00117 637887003577 Rhomboid family; Region: Rhomboid; pfam01694 637887003578 Tetratricopeptide repeat; Region: TPR_16; pfam13432 637887003579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887003580 TPR motif; other site 637887003581 binding surface 637887003582 Tetratricopeptide repeat; Region: TPR_16; pfam13432 637887003583 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637887003584 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637887003585 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 637887003586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887003587 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637887003588 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 637887003589 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 637887003590 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 637887003591 germination protease; Provisional; Region: PRK12362 637887003592 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 637887003593 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637887003594 active site 637887003595 metal binding site [ion binding]; metal-binding site 637887003596 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 637887003597 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 637887003598 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 637887003599 nucleotide binding pocket [chemical binding]; other site 637887003600 K-X-D-G motif; other site 637887003601 catalytic site [active] 637887003602 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637887003603 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 637887003604 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 637887003605 Dimer interface [polypeptide binding]; other site 637887003606 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 637887003607 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 637887003608 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 637887003609 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 637887003610 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 637887003611 GatB domain; Region: GatB_Yqey; smart00845 637887003612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887003613 binding surface 637887003614 TPR repeat; Region: TPR_11; pfam13414 637887003615 TPR motif; other site 637887003616 Tetratricopeptide repeat; Region: TPR_16; pfam13432 637887003617 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 637887003618 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 637887003619 propionate/acetate kinase; Provisional; Region: PRK12379 637887003620 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 637887003621 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 637887003622 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637887003623 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 637887003624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887003625 FeS/SAM binding site; other site 637887003626 Protein of unknown function (DUF512); Region: DUF512; pfam04459 637887003627 GTP-binding protein Der; Reviewed; Region: PRK00093 637887003628 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 637887003629 G1 box; other site 637887003630 GTP/Mg2+ binding site [chemical binding]; other site 637887003631 Switch I region; other site 637887003632 G2 box; other site 637887003633 Switch II region; other site 637887003634 G3 box; other site 637887003635 G4 box; other site 637887003636 G5 box; other site 637887003637 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 637887003638 G1 box; other site 637887003639 GTP/Mg2+ binding site [chemical binding]; other site 637887003640 Switch I region; other site 637887003641 G2 box; other site 637887003642 G3 box; other site 637887003643 Switch II region; other site 637887003644 G4 box; other site 637887003645 G5 box; other site 637887003646 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 637887003647 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 637887003648 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 637887003649 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 637887003650 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 637887003651 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 637887003652 G1 box; other site 637887003653 GTP/Mg2+ binding site [chemical binding]; other site 637887003654 G2 box; other site 637887003655 Switch I region; other site 637887003656 G3 box; other site 637887003657 Switch II region; other site 637887003658 G5 box; other site 637887003659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637887003660 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637887003661 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637887003662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887003663 dimer interface [polypeptide binding]; other site 637887003664 conserved gate region; other site 637887003665 putative PBP binding loops; other site 637887003666 ABC-ATPase subunit interface; other site 637887003667 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637887003668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887003669 dimer interface [polypeptide binding]; other site 637887003670 conserved gate region; other site 637887003671 putative PBP binding loops; other site 637887003672 ABC-ATPase subunit interface; other site 637887003673 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887003674 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 637887003675 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637887003676 active site 637887003677 metal binding site [ion binding]; metal-binding site 637887003678 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 637887003679 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 637887003680 MutS domain III; Region: MutS_III; pfam05192 637887003681 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 637887003682 Walker A/P-loop; other site 637887003683 ATP binding site [chemical binding]; other site 637887003684 Q-loop/lid; other site 637887003685 ABC transporter signature motif; other site 637887003686 Walker B; other site 637887003687 D-loop; other site 637887003688 H-loop/switch region; other site 637887003689 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 637887003690 Smr domain; Region: Smr; pfam01713 637887003691 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 637887003692 sporulation sigma factor SigK; Reviewed; Region: PRK05803 637887003693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887003694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887003695 DNA binding residues [nucleotide binding] 637887003696 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 637887003697 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637887003698 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637887003699 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637887003700 Peptidase family U32; Region: Peptidase_U32; pfam01136 637887003701 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 637887003702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887003703 S-adenosylmethionine binding site [chemical binding]; other site 637887003704 YceG-like family; Region: YceG; pfam02618 637887003705 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 637887003706 dimerization interface [polypeptide binding]; other site 637887003707 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 637887003708 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 637887003709 G1 box; other site 637887003710 putative GEF interaction site [polypeptide binding]; other site 637887003711 GTP/Mg2+ binding site [chemical binding]; other site 637887003712 Switch I region; other site 637887003713 G2 box; other site 637887003714 G3 box; other site 637887003715 Switch II region; other site 637887003716 G4 box; other site 637887003717 G5 box; other site 637887003718 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 637887003719 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 637887003720 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 637887003721 rRNA interaction site [nucleotide binding]; other site 637887003722 S8 interaction site; other site 637887003723 putative laminin-1 binding site; other site 637887003724 elongation factor Ts; Reviewed; Region: tsf; PRK12332 637887003725 UBA/TS-N domain; Region: UBA; pfam00627 637887003726 Elongation factor TS; Region: EF_TS; pfam00889 637887003727 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 637887003728 putative nucleotide binding site [chemical binding]; other site 637887003729 uridine monophosphate binding site [chemical binding]; other site 637887003730 homohexameric interface [polypeptide binding]; other site 637887003731 ribosome recycling factor; Reviewed; Region: frr; PRK00083 637887003732 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 637887003733 hinge region; other site 637887003734 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 637887003735 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 637887003736 catalytic residue [active] 637887003737 putative FPP diphosphate binding site; other site 637887003738 putative FPP binding hydrophobic cleft; other site 637887003739 dimer interface [polypeptide binding]; other site 637887003740 putative IPP diphosphate binding site; other site 637887003741 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 637887003742 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 637887003743 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 637887003744 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 637887003745 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 637887003746 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 637887003747 RIP metalloprotease RseP; Region: TIGR00054 637887003748 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637887003749 active site 637887003750 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637887003751 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637887003752 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 637887003753 putative substrate binding region [chemical binding]; other site 637887003754 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 637887003755 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 637887003756 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 637887003757 DNA polymerase III PolC; Validated; Region: polC; PRK00448 637887003758 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 637887003759 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 637887003760 generic binding surface II; other site 637887003761 generic binding surface I; other site 637887003762 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 637887003763 active site 637887003764 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637887003765 active site 637887003766 catalytic site [active] 637887003767 substrate binding site [chemical binding]; other site 637887003768 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 637887003769 ribosome maturation protein RimP; Reviewed; Region: PRK00092 637887003770 Sm and related proteins; Region: Sm_like; cl00259 637887003771 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 637887003772 putative oligomer interface [polypeptide binding]; other site 637887003773 putative RNA binding site [nucleotide binding]; other site 637887003774 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 637887003775 NusA N-terminal domain; Region: NusA_N; pfam08529 637887003776 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 637887003777 RNA binding site [nucleotide binding]; other site 637887003778 homodimer interface [polypeptide binding]; other site 637887003779 NusA-like KH domain; Region: KH_5; pfam13184 637887003780 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 637887003781 G-X-X-G motif; other site 637887003782 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 637887003783 putative RNA binding cleft [nucleotide binding]; other site 637887003784 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 637887003785 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637887003786 translation initiation factor IF-2; Validated; Region: infB; PRK05306 637887003787 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637887003788 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 637887003789 G1 box; other site 637887003790 putative GEF interaction site [polypeptide binding]; other site 637887003791 GTP/Mg2+ binding site [chemical binding]; other site 637887003792 Switch I region; other site 637887003793 G2 box; other site 637887003794 G3 box; other site 637887003795 Switch II region; other site 637887003796 G4 box; other site 637887003797 G5 box; other site 637887003798 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 637887003799 Translation-initiation factor 2; Region: IF-2; pfam11987 637887003800 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 637887003801 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 637887003802 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 637887003803 DHH family; Region: DHH; pfam01368 637887003804 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 637887003805 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 637887003806 RNA binding site [nucleotide binding]; other site 637887003807 active site 637887003808 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 637887003809 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 637887003810 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 637887003811 active site 637887003812 Riboflavin kinase; Region: Flavokinase; pfam01687 637887003813 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637887003814 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637887003815 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637887003816 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637887003817 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637887003818 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 637887003819 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 637887003820 MraZ protein; Region: MraZ; pfam02381 637887003821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 637887003822 MraZ protein; Region: MraZ; pfam02381 637887003823 MraW methylase family; Region: Methyltransf_5; pfam01795 637887003824 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 637887003825 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 637887003826 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637887003827 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637887003828 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 637887003829 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 637887003830 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 637887003831 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637887003832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887003833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637887003834 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 637887003835 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637887003836 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887003837 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637887003838 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 637887003839 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 637887003840 Mg++ binding site [ion binding]; other site 637887003841 putative catalytic motif [active] 637887003842 putative substrate binding site [chemical binding]; other site 637887003843 cell division protein FtsW; Region: ftsW; TIGR02614 637887003844 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 637887003845 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 637887003846 active site 637887003847 homodimer interface [polypeptide binding]; other site 637887003848 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 637887003849 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887003850 MULE transposase domain; Region: MULE; pfam10551 637887003851 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 637887003852 Family description; Region: UvrD_C_2; pfam13538 637887003853 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887003854 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 637887003855 homodimer interface [polypeptide binding]; other site 637887003856 Walker A motif; other site 637887003857 ATP binding site [chemical binding]; other site 637887003858 hydroxycobalamin binding site [chemical binding]; other site 637887003859 Walker B motif; other site 637887003860 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 637887003861 dihydrodipicolinate reductase; Provisional; Region: PRK00048 637887003862 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 637887003863 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 637887003864 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 637887003865 dihydrodipicolinate synthase; Region: dapA; TIGR00674 637887003866 dimer interface [polypeptide binding]; other site 637887003867 active site 637887003868 catalytic residue [active] 637887003869 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 637887003870 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637887003871 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637887003872 Stage II sporulation protein; Region: SpoIID; pfam08486 637887003873 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 637887003874 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 637887003875 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 637887003876 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 637887003877 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 637887003878 Preprotein translocase subunit; Region: YajC; pfam02699 637887003879 Carbohydrate binding domain; Region: CBM_25; smart01066 637887003880 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 637887003881 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 637887003882 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887003883 active site 637887003884 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 637887003885 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637887003886 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637887003887 dihydroorotase; Validated; Region: pyrC; PRK09357 637887003888 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637887003889 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 637887003890 active site 637887003891 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 637887003892 active site 637887003893 dimer interface [polypeptide binding]; other site 637887003894 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 637887003895 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 637887003896 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 637887003897 catalytic site [active] 637887003898 subunit interface [polypeptide binding]; other site 637887003899 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 637887003900 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637887003901 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637887003902 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 637887003903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637887003904 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637887003905 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 637887003906 IMP binding site; other site 637887003907 dimer interface [polypeptide binding]; other site 637887003908 interdomain contacts; other site 637887003909 partial ornithine binding site; other site 637887003910 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 637887003911 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 637887003912 FAD binding pocket [chemical binding]; other site 637887003913 FAD binding motif [chemical binding]; other site 637887003914 phosphate binding motif [ion binding]; other site 637887003915 beta-alpha-beta structure motif; other site 637887003916 NAD binding pocket [chemical binding]; other site 637887003917 Iron coordination center [ion binding]; other site 637887003918 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 637887003919 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 637887003920 heterodimer interface [polypeptide binding]; other site 637887003921 active site 637887003922 FMN binding site [chemical binding]; other site 637887003923 homodimer interface [polypeptide binding]; other site 637887003924 substrate binding site [chemical binding]; other site 637887003925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637887003926 catalytic core [active] 637887003927 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637887003928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637887003929 active site 637887003930 metal binding site [ion binding]; metal-binding site 637887003931 DNA binding site [nucleotide binding] 637887003932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887003933 AAA domain; Region: AAA_23; pfam13476 637887003934 Walker A/P-loop; other site 637887003935 ATP binding site [chemical binding]; other site 637887003936 ALIX V-shaped domain binding to HIV; Region: ALIX_LYPXL_bnd; pfam13949 637887003937 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 637887003938 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 637887003939 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637887003940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887003941 FeS/SAM binding site; other site 637887003942 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637887003943 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 637887003944 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 637887003945 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 637887003946 putative phosphate acyltransferase; Provisional; Region: PRK05331 637887003947 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 637887003948 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637887003949 dimer interface [polypeptide binding]; other site 637887003950 active site 637887003951 CoA binding pocket [chemical binding]; other site 637887003952 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 637887003953 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637887003954 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637887003955 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 637887003956 NAD(P) binding site [chemical binding]; other site 637887003957 homotetramer interface [polypeptide binding]; other site 637887003958 homodimer interface [polypeptide binding]; other site 637887003959 active site 637887003960 acyl carrier protein; Provisional; Region: acpP; PRK00982 637887003961 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 637887003962 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637887003963 dimer interface [polypeptide binding]; other site 637887003964 active site 637887003965 ribonuclease III; Reviewed; Region: rnc; PRK00102 637887003966 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 637887003967 dimerization interface [polypeptide binding]; other site 637887003968 active site 637887003969 metal binding site [ion binding]; metal-binding site 637887003970 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 637887003971 dsRNA binding site [nucleotide binding]; other site 637887003972 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 637887003973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887003974 FeS/SAM binding site; other site 637887003975 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 637887003976 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 637887003977 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 637887003978 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637887003979 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 637887003980 Walker A/P-loop; other site 637887003981 ATP binding site [chemical binding]; other site 637887003982 Q-loop/lid; other site 637887003983 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 637887003984 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 637887003985 ABC transporter signature motif; other site 637887003986 Walker B; other site 637887003987 D-loop; other site 637887003988 H-loop/switch region; other site 637887003989 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 637887003990 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 637887003991 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637887003992 P loop; other site 637887003993 GTP binding site [chemical binding]; other site 637887003994 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637887003995 putative active site [active] 637887003996 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 637887003997 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 637887003998 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 637887003999 Transposase; Region: HTH_Tnp_1; pfam01527 637887004000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887004001 HTH-like domain; Region: HTH_21; pfam13276 637887004002 Integrase core domain; Region: rve; pfam00665 637887004003 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887004004 Integrase core domain; Region: rve_3; pfam13683 637887004005 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 637887004006 Cna protein B-type domain; Region: Cna_B_2; pfam13715 637887004007 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 637887004008 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004009 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 637887004010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637887004011 active site 637887004012 HIGH motif; other site 637887004013 nucleotide binding site [chemical binding]; other site 637887004014 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 637887004015 KMSKS motif; other site 637887004016 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 637887004017 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 637887004018 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887004019 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 637887004020 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887004021 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004022 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004023 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 637887004024 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 637887004025 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 637887004026 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 637887004027 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 637887004028 peptide binding site [polypeptide binding]; other site 637887004029 dimer interface [polypeptide binding]; other site 637887004030 lipoprotein signal peptidase; Provisional; Region: PRK14791 637887004031 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637887004032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887004033 RNA binding surface [nucleotide binding]; other site 637887004034 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637887004035 active site 637887004036 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 637887004037 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 637887004038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887004039 FeS/SAM binding site; other site 637887004040 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637887004041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887004042 Zn2+ binding site [ion binding]; other site 637887004043 Mg2+ binding site [ion binding]; other site 637887004044 protein-export membrane protein SecD; Region: secD; TIGR01129 637887004045 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 637887004046 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 637887004047 Protein export membrane protein; Region: SecD_SecF; cl14618 637887004048 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 637887004049 oligomerization interface [polypeptide binding]; other site 637887004050 active site 637887004051 metal binding site [ion binding]; metal-binding site 637887004052 pantoate--beta-alanine ligase; Region: panC; TIGR00018 637887004053 Pantoate-beta-alanine ligase; Region: PanC; cd00560 637887004054 active site 637887004055 ATP-binding site [chemical binding]; other site 637887004056 pantoate-binding site; other site 637887004057 HXXH motif; other site 637887004058 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 637887004059 tetramerization interface [polypeptide binding]; other site 637887004060 active site 637887004061 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887004062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887004063 Zn2+ binding site [ion binding]; other site 637887004064 Mg2+ binding site [ion binding]; other site 637887004065 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 637887004066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887004067 Zn2+ binding site [ion binding]; other site 637887004068 Mg2+ binding site [ion binding]; other site 637887004069 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 637887004070 DNA primase; Validated; Region: dnaG; PRK05667 637887004071 CHC2 zinc finger; Region: zf-CHC2; pfam01807 637887004072 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 637887004073 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 637887004074 active site 637887004075 metal binding site [ion binding]; metal-binding site 637887004076 interdomain interaction site; other site 637887004077 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 637887004078 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 637887004079 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 637887004080 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637887004081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887004082 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637887004083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887004084 DNA binding residues [nucleotide binding] 637887004085 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 637887004086 Family of unknown function (DUF633); Region: DUF633; pfam04816 637887004087 Uncharacterized conserved protein [Function unknown]; Region: COG0327 637887004088 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 637887004089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 637887004090 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 637887004091 Uncharacterized conserved protein [Function unknown]; Region: COG0327 637887004092 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 637887004093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004094 active site 637887004095 phosphorylation site [posttranslational modification] 637887004096 intermolecular recognition site; other site 637887004097 dimerization interface [polypeptide binding]; other site 637887004098 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 637887004099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887004100 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887004101 DNA binding residues [nucleotide binding] 637887004102 Putative zinc-finger; Region: zf-HC2; pfam13490 637887004103 PilZ domain; Region: PilZ; pfam07238 637887004104 DNA polymerase I; Provisional; Region: PRK05755 637887004105 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637887004106 active site 637887004107 metal binding site 1 [ion binding]; metal-binding site 637887004108 putative 5' ssDNA interaction site; other site 637887004109 metal binding site 3; metal-binding site 637887004110 metal binding site 2 [ion binding]; metal-binding site 637887004111 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637887004112 putative DNA binding site [nucleotide binding]; other site 637887004113 putative metal binding site [ion binding]; other site 637887004114 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 637887004115 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 637887004116 active site 637887004117 DNA binding site [nucleotide binding] 637887004118 catalytic site [active] 637887004119 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 637887004120 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 637887004121 CoA-binding site [chemical binding]; other site 637887004122 ATP-binding [chemical binding]; other site 637887004123 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 637887004124 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637887004125 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637887004126 catalytic residue [active] 637887004127 flagellar operon protein TIGR03826; Region: YvyF 637887004128 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637887004129 EamA-like transporter family; Region: EamA; pfam00892 637887004130 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887004131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887004132 metal binding site [ion binding]; metal-binding site 637887004133 active site 637887004134 I-site; other site 637887004135 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 637887004136 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 637887004137 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 637887004138 GTP-binding protein YchF; Reviewed; Region: PRK09601 637887004139 YchF GTPase; Region: YchF; cd01900 637887004140 G1 box; other site 637887004141 GTP/Mg2+ binding site [chemical binding]; other site 637887004142 Switch I region; other site 637887004143 G2 box; other site 637887004144 Switch II region; other site 637887004145 G3 box; other site 637887004146 G4 box; other site 637887004147 G5 box; other site 637887004148 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 637887004149 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 637887004150 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 637887004151 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637887004152 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 637887004153 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 637887004154 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637887004155 glutamine binding [chemical binding]; other site 637887004156 catalytic triad [active] 637887004157 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 637887004158 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637887004159 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637887004160 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 637887004161 active site 637887004162 ribulose/triose binding site [chemical binding]; other site 637887004163 phosphate binding site [ion binding]; other site 637887004164 substrate (anthranilate) binding pocket [chemical binding]; other site 637887004165 product (indole) binding pocket [chemical binding]; other site 637887004166 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 637887004167 active site 637887004168 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637887004169 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 637887004170 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 637887004171 PilZ domain; Region: PilZ; pfam07238 637887004172 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 637887004173 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887004174 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 637887004175 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637887004176 dimer interface [polypeptide binding]; other site 637887004177 PYR/PP interface [polypeptide binding]; other site 637887004178 TPP binding site [chemical binding]; other site 637887004179 substrate binding site [chemical binding]; other site 637887004180 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637887004181 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 637887004182 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 637887004183 TPP-binding site [chemical binding]; other site 637887004184 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 637887004185 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 637887004186 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 637887004187 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 637887004188 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637887004189 YmaF family; Region: YmaF; pfam12788 637887004190 Transcriptional regulator [Transcription]; Region: LytR; COG1316 637887004191 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 637887004192 Ferritin-like domain; Region: Ferritin; pfam00210 637887004193 binuclear metal center [ion binding]; other site 637887004194 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 637887004195 iron binding site [ion binding]; other site 637887004196 hypothetical protein; Provisional; Region: PRK13665 637887004197 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 637887004198 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 637887004199 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 637887004200 homodimer interface [polypeptide binding]; other site 637887004201 substrate-cofactor binding pocket; other site 637887004202 catalytic residue [active] 637887004203 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 637887004204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887004205 active site 637887004206 motif I; other site 637887004207 motif II; other site 637887004208 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 637887004209 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637887004210 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637887004211 shikimate binding site; other site 637887004212 NAD(P) binding site [chemical binding]; other site 637887004213 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 637887004214 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 637887004215 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637887004216 Walker A motif; other site 637887004217 ATP binding site [chemical binding]; other site 637887004218 Walker B motif; other site 637887004219 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637887004220 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 637887004221 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 637887004222 Late competence development protein ComFB; Region: ComFB; pfam10719 637887004223 AP endonuclease family 2; Region: AP2Ec; smart00518 637887004224 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 637887004225 Metal-binding active site; metal-binding site 637887004226 AP (apurinic/apyrimidinic) site pocket; other site 637887004227 Dehydroquinase class II; Region: DHquinase_II; pfam01220 637887004228 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 637887004229 trimer interface [polypeptide binding]; other site 637887004230 active site 637887004231 dimer interface [polypeptide binding]; other site 637887004232 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637887004233 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637887004234 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637887004235 active site 637887004236 elongation factor P; Validated; Region: PRK00529 637887004237 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637887004238 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 637887004239 RNA binding site [nucleotide binding]; other site 637887004240 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 637887004241 RNA binding site [nucleotide binding]; other site 637887004242 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 637887004243 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887004244 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 637887004245 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637887004246 Walker A motif; other site 637887004247 ATP binding site [chemical binding]; other site 637887004248 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 637887004249 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 637887004250 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 637887004251 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 637887004252 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 637887004253 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 637887004254 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 637887004255 Asp23 family; Region: Asp23; pfam03780 637887004256 Asp23 family; Region: Asp23; pfam03780 637887004257 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 637887004258 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 637887004259 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 637887004260 putative RNA binding site [nucleotide binding]; other site 637887004261 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 637887004262 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 637887004263 generic binding surface II; other site 637887004264 generic binding surface I; other site 637887004265 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 637887004266 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637887004267 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637887004268 substrate binding pocket [chemical binding]; other site 637887004269 chain length determination region; other site 637887004270 substrate-Mg2+ binding site; other site 637887004271 catalytic residues [active] 637887004272 aspartate-rich region 1; other site 637887004273 active site lid residues [active] 637887004274 aspartate-rich region 2; other site 637887004275 Divergent PAP2 family; Region: DUF212; pfam02681 637887004276 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 637887004277 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 637887004278 TPP-binding site; other site 637887004279 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637887004280 PYR/PP interface [polypeptide binding]; other site 637887004281 dimer interface [polypeptide binding]; other site 637887004282 TPP binding site [chemical binding]; other site 637887004283 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637887004284 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 637887004285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887004286 RNA binding surface [nucleotide binding]; other site 637887004287 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 637887004288 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 637887004289 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887004290 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004291 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004292 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887004293 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887004294 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 637887004295 sugar binding site [chemical binding]; other site 637887004296 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004297 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004298 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637887004299 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 637887004300 Walker A/P-loop; other site 637887004301 ATP binding site [chemical binding]; other site 637887004302 Q-loop/lid; other site 637887004303 ABC transporter signature motif; other site 637887004304 Walker B; other site 637887004305 D-loop; other site 637887004306 H-loop/switch region; other site 637887004307 Catalytic domain of Protein Kinases; Region: PKc; cd00180 637887004308 active site 637887004309 ATP binding site [chemical binding]; other site 637887004310 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 637887004311 substrate binding site [chemical binding]; other site 637887004312 activation loop (A-loop); other site 637887004313 AAA ATPase domain; Region: AAA_16; pfam13191 637887004314 Archaeal ATPase; Region: Arch_ATPase; pfam01637 637887004315 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887004316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887004317 binding surface 637887004318 TPR motif; other site 637887004319 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887004320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887004321 TPR motif; other site 637887004322 binding surface 637887004323 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887004324 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887004325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887004326 binding surface 637887004327 TPR motif; other site 637887004328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887004329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887004330 metal binding site [ion binding]; metal-binding site 637887004331 active site 637887004332 I-site; other site 637887004333 GAF domain; Region: GAF; cl17456 637887004334 GAF domain; Region: GAF_2; pfam13185 637887004335 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 637887004336 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 637887004337 arginine repressor; Provisional; Region: argR; PRK00441 637887004338 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637887004339 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637887004340 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 637887004341 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637887004342 Walker A/P-loop; other site 637887004343 ATP binding site [chemical binding]; other site 637887004344 Q-loop/lid; other site 637887004345 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637887004346 ABC transporter signature motif; other site 637887004347 Walker B; other site 637887004348 D-loop; other site 637887004349 H-loop/switch region; other site 637887004350 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 637887004351 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637887004352 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 637887004353 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 637887004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004355 active site 637887004356 phosphorylation site [posttranslational modification] 637887004357 intermolecular recognition site; other site 637887004358 dimerization interface [polypeptide binding]; other site 637887004359 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 637887004360 Response regulator receiver domain; Region: Response_reg; pfam00072 637887004361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004362 active site 637887004363 phosphorylation site [posttranslational modification] 637887004364 intermolecular recognition site; other site 637887004365 dimerization interface [polypeptide binding]; other site 637887004366 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 637887004367 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637887004368 putative binding surface; other site 637887004369 active site 637887004370 P2 response regulator binding domain; Region: P2; pfam07194 637887004371 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637887004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887004373 ATP binding site [chemical binding]; other site 637887004374 Mg2+ binding site [ion binding]; other site 637887004375 G-X-G motif; other site 637887004376 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637887004377 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 637887004378 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 637887004379 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 637887004380 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 637887004381 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 637887004382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004383 active site 637887004384 phosphorylation site [posttranslational modification] 637887004385 intermolecular recognition site; other site 637887004386 dimerization interface [polypeptide binding]; other site 637887004387 CheB methylesterase; Region: CheB_methylest; pfam01339 637887004388 PAS domain S-box; Region: sensory_box; TIGR00229 637887004389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637887004390 putative active site [active] 637887004391 heme pocket [chemical binding]; other site 637887004392 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 637887004393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637887004394 putative active site [active] 637887004395 heme pocket [chemical binding]; other site 637887004396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887004397 dimer interface [polypeptide binding]; other site 637887004398 phosphorylation site [posttranslational modification] 637887004399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887004400 ATP binding site [chemical binding]; other site 637887004401 Mg2+ binding site [ion binding]; other site 637887004402 G-X-G motif; other site 637887004403 Response regulator receiver domain; Region: Response_reg; pfam00072 637887004404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004405 active site 637887004406 phosphorylation site [posttranslational modification] 637887004407 intermolecular recognition site; other site 637887004408 dimerization interface [polypeptide binding]; other site 637887004409 Response regulator receiver domain; Region: Response_reg; pfam00072 637887004410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004411 active site 637887004412 phosphorylation site [posttranslational modification] 637887004413 intermolecular recognition site; other site 637887004414 dimerization interface [polypeptide binding]; other site 637887004415 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 637887004416 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 637887004417 DNA binding residues [nucleotide binding] 637887004418 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637887004419 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637887004420 active site 637887004421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887004422 MULE transposase domain; Region: MULE; pfam10551 637887004423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887004424 dimer interface [polypeptide binding]; other site 637887004425 phosphorylation site [posttranslational modification] 637887004426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887004427 ATP binding site [chemical binding]; other site 637887004428 Mg2+ binding site [ion binding]; other site 637887004429 G-X-G motif; other site 637887004430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887004431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004432 active site 637887004433 phosphorylation site [posttranslational modification] 637887004434 intermolecular recognition site; other site 637887004435 dimerization interface [polypeptide binding]; other site 637887004436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887004437 DNA binding site [nucleotide binding] 637887004438 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 637887004439 active site 637887004440 catalytic triad [active] 637887004441 oxyanion hole [active] 637887004442 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 637887004443 active site 637887004444 catalytic triad [active] 637887004445 oxyanion hole [active] 637887004446 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004447 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004448 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 637887004449 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887004450 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004451 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004452 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 637887004453 active site 637887004454 catalytic triad [active] 637887004455 oxyanion hole [active] 637887004456 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 637887004457 homodimer interface [polypeptide binding]; other site 637887004458 maltodextrin glucosidase; Provisional; Region: PRK10785 637887004459 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 637887004460 active site 637887004461 homodimer interface [polypeptide binding]; other site 637887004462 catalytic site [active] 637887004463 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 637887004464 Aluminium resistance protein; Region: Alum_res; pfam06838 637887004465 HlyD family secretion protein; Region: HlyD_2; pfam12700 637887004466 putative membrane fusion protein; Region: TIGR02828 637887004467 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 637887004468 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637887004469 catalytic residue [active] 637887004470 Protein of unknown function (DUF552); Region: DUF552; pfam04472 637887004471 YGGT family; Region: YGGT; pfam02325 637887004472 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 637887004473 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 637887004474 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887004475 RNA binding surface [nucleotide binding]; other site 637887004476 DivIVA protein; Region: DivIVA; pfam05103 637887004477 DivIVA domain; Region: DivI1A_domain; TIGR03544 637887004478 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 637887004479 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637887004480 HIGH motif; other site 637887004481 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637887004482 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637887004483 active site 637887004484 KMSKS motif; other site 637887004485 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 637887004486 tRNA binding surface [nucleotide binding]; other site 637887004487 anticodon binding site; other site 637887004488 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637887004489 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 637887004490 active site 637887004491 dimer interface [polypeptide binding]; other site 637887004492 metal binding site [ion binding]; metal-binding site 637887004493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887004494 active site 637887004495 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 637887004496 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637887004497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887004498 FeS/SAM binding site; other site 637887004499 TRAM domain; Region: TRAM; cl01282 637887004500 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637887004501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887004502 dimerization interface [polypeptide binding]; other site 637887004503 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887004504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887004505 dimer interface [polypeptide binding]; other site 637887004506 putative CheW interface [polypeptide binding]; other site 637887004507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637887004508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887004509 Coenzyme A binding pocket [chemical binding]; other site 637887004510 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 637887004511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887004512 motif II; other site 637887004513 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887004514 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 637887004515 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 637887004516 Protein of unknown function (DUF964); Region: DUF964; pfam06133 637887004517 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 637887004518 MutS domain I; Region: MutS_I; pfam01624 637887004519 MutS domain II; Region: MutS_II; pfam05188 637887004520 MutS domain III; Region: MutS_III; pfam05192 637887004521 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 637887004522 Walker A/P-loop; other site 637887004523 ATP binding site [chemical binding]; other site 637887004524 Q-loop/lid; other site 637887004525 ABC transporter signature motif; other site 637887004526 Walker B; other site 637887004527 D-loop; other site 637887004528 H-loop/switch region; other site 637887004529 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 637887004530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887004531 ATP binding site [chemical binding]; other site 637887004532 Mg2+ binding site [ion binding]; other site 637887004533 G-X-G motif; other site 637887004534 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 637887004535 ATP binding site [chemical binding]; other site 637887004536 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 637887004537 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 637887004538 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 637887004539 bacterial Hfq-like; Region: Hfq; cd01716 637887004540 hexamer interface [polypeptide binding]; other site 637887004541 Sm1 motif; other site 637887004542 RNA binding site [nucleotide binding]; other site 637887004543 Sm2 motif; other site 637887004544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637887004545 LexA repressor; Validated; Region: PRK00215 637887004546 putative DNA binding site [nucleotide binding]; other site 637887004547 putative Zn2+ binding site [ion binding]; other site 637887004548 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637887004549 Catalytic site [active] 637887004550 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887004551 putative DNA-binding protein; Validated; Region: PRK00118 637887004552 signal recognition particle protein; Provisional; Region: PRK10867 637887004553 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 637887004554 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637887004555 P loop; other site 637887004556 GTP binding site [chemical binding]; other site 637887004557 Signal peptide binding domain; Region: SRP_SPB; pfam02978 637887004558 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 637887004559 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 637887004560 hypothetical protein; Provisional; Region: PRK00468 637887004561 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 637887004562 RimM N-terminal domain; Region: RimM; pfam01782 637887004563 PRC-barrel domain; Region: PRC; pfam05239 637887004564 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 637887004565 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 637887004566 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637887004567 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637887004568 Catalytic site [active] 637887004569 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 637887004570 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 637887004571 GTP/Mg2+ binding site [chemical binding]; other site 637887004572 G4 box; other site 637887004573 G5 box; other site 637887004574 G1 box; other site 637887004575 Switch I region; other site 637887004576 G2 box; other site 637887004577 G3 box; other site 637887004578 Switch II region; other site 637887004579 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 637887004580 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 637887004581 RNA/DNA hybrid binding site [nucleotide binding]; other site 637887004582 active site 637887004583 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 637887004584 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 637887004585 hypothetical protein; Reviewed; Region: PRK12497 637887004586 hypothetical protein; Reviewed; Region: PRK00024 637887004587 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637887004588 MPN+ (JAMM) motif; other site 637887004589 Zinc-binding site [ion binding]; other site 637887004590 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 637887004591 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 637887004592 active site 637887004593 dimer interface [polypeptide binding]; other site 637887004594 aspartate aminotransferase; Provisional; Region: PRK05764 637887004595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887004596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887004597 homodimer interface [polypeptide binding]; other site 637887004598 catalytic residue [active] 637887004599 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637887004600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637887004601 non-specific DNA binding site [nucleotide binding]; other site 637887004602 salt bridge; other site 637887004603 sequence-specific DNA binding site [nucleotide binding]; other site 637887004604 Cupin domain; Region: Cupin_2; pfam07883 637887004605 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637887004606 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 637887004607 Walker A/P-loop; other site 637887004608 ATP binding site [chemical binding]; other site 637887004609 Q-loop/lid; other site 637887004610 ABC transporter signature motif; other site 637887004611 Walker B; other site 637887004612 D-loop; other site 637887004613 H-loop/switch region; other site 637887004614 TOBE domain; Region: TOBE_2; pfam08402 637887004615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887004616 dimer interface [polypeptide binding]; other site 637887004617 conserved gate region; other site 637887004618 putative PBP binding loops; other site 637887004619 ABC-ATPase subunit interface; other site 637887004620 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637887004621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887004622 dimer interface [polypeptide binding]; other site 637887004623 conserved gate region; other site 637887004624 putative PBP binding loops; other site 637887004625 ABC-ATPase subunit interface; other site 637887004626 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 637887004627 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 637887004628 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 637887004629 endoglucanase; Region: PLN02420 637887004630 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887004631 Cellulose binding domain; Region: CBM_3; smart01067 637887004632 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004633 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887004634 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 637887004635 Catalytic dyad [active] 637887004636 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637887004637 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 637887004638 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 637887004639 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 637887004640 tetramer interface [polypeptide binding]; other site 637887004641 active site 637887004642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637887004643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637887004644 DNA-binding site [nucleotide binding]; DNA binding site 637887004645 UTRA domain; Region: UTRA; pfam07702 637887004646 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 637887004647 Trp docking motif [polypeptide binding]; other site 637887004648 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637887004649 metal-binding site [ion binding] 637887004650 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 637887004651 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004652 dockerin binding interface; other site 637887004653 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004654 dockerin binding interface; other site 637887004655 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004656 dockerin binding interface; other site 637887004657 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004658 dockerin binding interface; other site 637887004659 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004660 dockerin binding interface; other site 637887004661 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004662 dockerin binding interface; other site 637887004663 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004664 dockerin binding interface; other site 637887004665 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637887004666 dockerin binding interface; other site 637887004667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 637887004668 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637887004669 Peptidase family M23; Region: Peptidase_M23; pfam01551 637887004670 PilZ domain; Region: PilZ; pfam07238 637887004671 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 637887004672 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 637887004673 Tetramer interface [polypeptide binding]; other site 637887004674 active site 637887004675 FMN-binding site [chemical binding]; other site 637887004676 shikimate kinase; Reviewed; Region: aroK; PRK00131 637887004677 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 637887004678 ADP binding site [chemical binding]; other site 637887004679 magnesium binding site [ion binding]; other site 637887004680 putative shikimate binding site; other site 637887004681 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004682 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 637887004683 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 637887004684 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637887004685 active site 637887004686 DNA binding site [nucleotide binding] 637887004687 Int/Topo IB signature motif; other site 637887004688 Transcriptional regulator [Transcription]; Region: LytR; COG1316 637887004689 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 637887004690 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 637887004691 oligomer interface [polypeptide binding]; other site 637887004692 putative active site [active] 637887004693 metal binding site [ion binding]; metal-binding site 637887004694 Response regulator receiver domain; Region: Response_reg; pfam00072 637887004695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887004696 active site 637887004697 phosphorylation site [posttranslational modification] 637887004698 intermolecular recognition site; other site 637887004699 dimerization interface [polypeptide binding]; other site 637887004700 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 637887004701 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887004702 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887004703 Zn2+ binding site [ion binding]; other site 637887004704 Mg2+ binding site [ion binding]; other site 637887004705 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 637887004706 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 637887004707 active site 637887004708 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 637887004709 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 637887004710 active site 637887004711 HIGH motif; other site 637887004712 dimer interface [polypeptide binding]; other site 637887004713 KMSKS motif; other site 637887004714 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887004715 RNA binding surface [nucleotide binding]; other site 637887004716 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 637887004717 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 637887004718 Ligand Binding Site [chemical binding]; other site 637887004719 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 637887004720 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 637887004721 trimerization site [polypeptide binding]; other site 637887004722 active site 637887004723 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 637887004724 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 637887004725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637887004726 catalytic residue [active] 637887004727 Predicted transcriptional regulator [Transcription]; Region: COG1959 637887004728 Transcriptional regulator; Region: Rrf2; cl17282 637887004729 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 637887004730 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 637887004731 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 637887004732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887004733 S-adenosylmethionine binding site [chemical binding]; other site 637887004734 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 637887004735 active site 637887004736 multimer interface [polypeptide binding]; other site 637887004737 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 637887004738 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 637887004739 LytB protein; Region: LYTB; cl00507 637887004740 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 637887004741 RNA binding site [nucleotide binding]; other site 637887004742 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 637887004743 RNA binding site [nucleotide binding]; other site 637887004744 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 637887004745 RNA binding site [nucleotide binding]; other site 637887004746 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 637887004747 RNA binding site [nucleotide binding]; other site 637887004748 domain interface; other site 637887004749 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 637887004750 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637887004751 putative acyl-acceptor binding pocket; other site 637887004752 cytidylate kinase; Provisional; Region: cmk; PRK00023 637887004753 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 637887004754 CMP-binding site; other site 637887004755 The sites determining sugar specificity; other site 637887004756 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 637887004757 homotrimer interaction site [polypeptide binding]; other site 637887004758 active site 637887004759 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 637887004760 hexamer interface [polypeptide binding]; other site 637887004761 RNA binding site [nucleotide binding]; other site 637887004762 Histidine-zinc binding site [chemical binding]; other site 637887004763 HI0933-like protein; Region: HI0933_like; pfam03486 637887004764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637887004765 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637887004766 catalytic core [active] 637887004767 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637887004768 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637887004769 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637887004770 putative active site [active] 637887004771 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 637887004772 oxaloacetate decarboxylase; Provisional; Region: PRK12331 637887004773 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 637887004774 active site 637887004775 catalytic residues [active] 637887004776 metal binding site [ion binding]; metal-binding site 637887004777 homodimer binding site [polypeptide binding]; other site 637887004778 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 637887004779 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 637887004780 carboxyltransferase (CT) interaction site; other site 637887004781 biotinylation site [posttranslational modification]; other site 637887004782 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 637887004783 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 637887004784 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 637887004785 PilZ domain; Region: PilZ; pfam07238 637887004786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887004787 S-adenosylmethionine binding site [chemical binding]; other site 637887004788 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 637887004789 agmatinase; Region: agmatinase; TIGR01230 637887004790 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 637887004791 putative active site [active] 637887004792 Mn binding site [ion binding]; other site 637887004793 spermidine synthase; Provisional; Region: PRK00811 637887004794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887004795 S-adenosylmethionine binding site [chemical binding]; other site 637887004796 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637887004797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637887004798 RNA binding surface [nucleotide binding]; other site 637887004799 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 637887004800 active site 637887004801 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 637887004802 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 637887004803 RDD family; Region: RDD; pfam06271 637887004804 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 637887004805 ScpA/B protein; Region: ScpA_ScpB; cl00598 637887004806 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 637887004807 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 637887004808 active site 637887004809 HIGH motif; other site 637887004810 dimer interface [polypeptide binding]; other site 637887004811 KMSKS motif; other site 637887004812 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 637887004813 Peptidase family M50; Region: Peptidase_M50; pfam02163 637887004814 active site 637887004815 putative substrate binding region [chemical binding]; other site 637887004816 DHH family; Region: DHH; pfam01368 637887004817 FOG: CBS domain [General function prediction only]; Region: COG0517 637887004818 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 637887004819 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 637887004820 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637887004821 active site 637887004822 NTP binding site [chemical binding]; other site 637887004823 metal binding triad [ion binding]; metal-binding site 637887004824 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637887004825 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 637887004826 diaminopimelate decarboxylase; Region: lysA; TIGR01048 637887004827 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 637887004828 active site 637887004829 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637887004830 substrate binding site [chemical binding]; other site 637887004831 catalytic residues [active] 637887004832 dimer interface [polypeptide binding]; other site 637887004833 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 637887004834 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 637887004835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 637887004836 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 637887004837 active site 637887004838 LysE type translocator; Region: LysE; cl00565 637887004839 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637887004840 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637887004841 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637887004842 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637887004843 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 637887004844 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637887004845 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 637887004846 phosphopentomutase; Provisional; Region: PRK05362 637887004847 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 637887004848 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 637887004849 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 637887004850 active site 637887004851 Int/Topo IB signature motif; other site 637887004852 Integral membrane protein DUF95; Region: DUF95; cl00572 637887004853 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637887004854 dimer interface [polypeptide binding]; other site 637887004855 ADP-ribose binding site [chemical binding]; other site 637887004856 active site 637887004857 nudix motif; other site 637887004858 metal binding site [ion binding]; metal-binding site 637887004859 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 637887004860 RNA/DNA hybrid binding site [nucleotide binding]; other site 637887004861 active site 637887004862 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 637887004863 pyrroline-5-carboxylate reductase; Region: PLN02688 637887004864 Spore germination protein; Region: Spore_permease; cl17796 637887004865 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 637887004866 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 637887004867 Spore germination protein; Region: Spore_permease; cl17796 637887004868 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637887004869 HflC protein; Region: hflC; TIGR01932 637887004870 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 637887004871 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 637887004872 HflK protein; Region: hflK; TIGR01933 637887004873 Homeobox associated leucine zipper; Region: HALZ; pfam02183 637887004874 3D domain; Region: 3D; pfam06725 637887004875 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 637887004876 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 637887004877 active site 637887004878 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 637887004879 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 637887004880 putative sugar binding sites [chemical binding]; other site 637887004881 Q-X-W motif; other site 637887004882 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004883 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004884 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 637887004885 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004886 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004887 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 637887004888 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 637887004889 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 637887004890 Competence protein A; Region: Competence_A; pfam11104 637887004891 Cell division protein FtsA; Region: FtsA; pfam14450 637887004892 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637887004893 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637887004894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637887004895 catalytic residue [active] 637887004896 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 637887004897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887004898 FeS/SAM binding site; other site 637887004899 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 637887004900 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 637887004901 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 637887004902 active site 1 [active] 637887004903 dimer interface [polypeptide binding]; other site 637887004904 hexamer interface [polypeptide binding]; other site 637887004905 active site 2 [active] 637887004906 AAA domain; Region: AAA_22; pfam13401 637887004907 AAA domain; Region: AAA_17; pfam13207 637887004908 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 637887004909 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637887004910 active site 637887004911 HIGH motif; other site 637887004912 nucleotide binding site [chemical binding]; other site 637887004913 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637887004914 active site 637887004915 KMSKS motif; other site 637887004916 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 637887004917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887004918 FeS/SAM binding site; other site 637887004919 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 637887004920 ATP cone domain; Region: ATP-cone; pfam03477 637887004921 Class III ribonucleotide reductase; Region: RNR_III; cd01675 637887004922 effector binding site; other site 637887004923 active site 637887004924 Zn binding site [ion binding]; other site 637887004925 glycine loop; other site 637887004926 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 637887004927 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 637887004928 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 637887004929 substrate binding pocket [chemical binding]; other site 637887004930 dimer interface [polypeptide binding]; other site 637887004931 inhibitor binding site; inhibition site 637887004932 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 637887004933 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 637887004934 B12 binding site [chemical binding]; other site 637887004935 cobalt ligand [ion binding]; other site 637887004936 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 637887004937 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 637887004938 Coat F domain; Region: Coat_F; pfam07875 637887004939 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 637887004940 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 637887004941 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004942 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004943 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 637887004944 FHA domain; Region: FHA; pfam00498 637887004945 phosphopeptide binding site; other site 637887004946 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 637887004947 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 637887004948 phosphopeptide binding site; other site 637887004949 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 637887004950 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637887004951 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637887004952 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637887004953 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 637887004954 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 637887004955 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 637887004956 Protein phosphatase 2C; Region: PP2C; pfam00481 637887004957 active site 637887004958 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 637887004959 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637887004960 active site 637887004961 ATP binding site [chemical binding]; other site 637887004962 substrate binding site [chemical binding]; other site 637887004963 activation loop (A-loop); other site 637887004964 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 637887004965 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637887004966 Walker A motif; other site 637887004967 ATP binding site [chemical binding]; other site 637887004968 Walker B motif; other site 637887004969 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 637887004970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637887004971 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 637887004972 AAA domain; Region: AAA_31; pfam13614 637887004973 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637887004974 endoglucanase; Region: PLN02420 637887004975 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887004976 Cellulose binding domain; Region: CBM_3; smart01067 637887004977 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004978 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004979 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 637887004980 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 637887004981 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 637887004982 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004983 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887004984 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 637887004985 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 637887004986 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637887004987 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 637887004988 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 637887004989 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 637887004990 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 637887004991 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 637887004992 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 637887004993 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 637887004994 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 637887004995 G1 box; other site 637887004996 GTP/Mg2+ binding site [chemical binding]; other site 637887004997 Switch I region; other site 637887004998 G2 box; other site 637887004999 G3 box; other site 637887005000 Switch II region; other site 637887005001 G4 box; other site 637887005002 G5 box; other site 637887005003 Nucleoside recognition; Region: Gate; pfam07670 637887005004 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 637887005005 Nucleoside recognition; Region: Gate; pfam07670 637887005006 recombination factor protein RarA; Reviewed; Region: PRK13342 637887005007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887005008 Walker A motif; other site 637887005009 ATP binding site [chemical binding]; other site 637887005010 Walker B motif; other site 637887005011 arginine finger; other site 637887005012 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 637887005013 ACT domain-containing protein [General function prediction only]; Region: COG4747 637887005014 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 637887005015 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 637887005016 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 637887005017 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637887005018 acyl-activating enzyme (AAE) consensus motif; other site 637887005019 AMP binding site [chemical binding]; other site 637887005020 active site 637887005021 CoA binding site [chemical binding]; other site 637887005022 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 637887005023 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 637887005024 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 637887005025 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637887005026 dimer interface [polypeptide binding]; other site 637887005027 PYR/PP interface [polypeptide binding]; other site 637887005028 TPP binding site [chemical binding]; other site 637887005029 substrate binding site [chemical binding]; other site 637887005030 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 637887005031 TPP-binding site; other site 637887005032 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 637887005033 Na binding site [ion binding]; other site 637887005034 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 637887005035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887005036 Beta-Casp domain; Region: Beta-Casp; smart01027 637887005037 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637887005038 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 637887005039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887005040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887005041 homodimer interface [polypeptide binding]; other site 637887005042 catalytic residue [active] 637887005043 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637887005044 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 637887005045 oligomer interface [polypeptide binding]; other site 637887005046 active site 637887005047 metal binding site [ion binding]; metal-binding site 637887005048 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637887005049 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 637887005050 oligomer interface [polypeptide binding]; other site 637887005051 active site 637887005052 metal binding site [ion binding]; metal-binding site 637887005053 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637887005054 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 637887005055 oligomer interface [polypeptide binding]; other site 637887005056 active site 637887005057 metal binding site [ion binding]; metal-binding site 637887005058 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 637887005059 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 637887005060 Competence protein; Region: Competence; pfam03772 637887005061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887005062 Bacterial SH3 domain; Region: SH3_3; pfam08239 637887005063 Bacterial SH3 domain; Region: SH3_3; pfam08239 637887005064 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637887005065 NlpC/P60 family; Region: NLPC_P60; pfam00877 637887005066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 637887005067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887005068 Coenzyme A binding pocket [chemical binding]; other site 637887005069 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 637887005070 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 637887005071 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 637887005072 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 637887005073 thiamine phosphate binding site [chemical binding]; other site 637887005074 active site 637887005075 pyrophosphate binding site [ion binding]; other site 637887005076 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 637887005077 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 637887005078 putative ATP binding site [chemical binding]; other site 637887005079 putative substrate interface [chemical binding]; other site 637887005080 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 637887005081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887005082 FeS/SAM binding site; other site 637887005083 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 637887005084 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 637887005085 ThiS interaction site; other site 637887005086 putative active site [active] 637887005087 tetramer interface [polypeptide binding]; other site 637887005088 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 637887005089 thiS-thiF/thiG interaction site; other site 637887005090 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 637887005091 G1 box; other site 637887005092 GTP/Mg2+ binding site [chemical binding]; other site 637887005093 Switch I region; other site 637887005094 G2 box; other site 637887005095 G3 box; other site 637887005096 Switch II region; other site 637887005097 G4 box; other site 637887005098 G5 box; other site 637887005099 chaperone protein DnaJ; Provisional; Region: PRK10767 637887005100 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887005101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887005102 S-adenosylmethionine binding site [chemical binding]; other site 637887005103 Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211 637887005104 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637887005105 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637887005106 catalytic residues [active] 637887005107 catalytic nucleophile [active] 637887005108 Recombinase; Region: Recombinase; pfam07508 637887005109 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 637887005110 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637887005111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887005112 ATP binding site [chemical binding]; other site 637887005113 putative Mg++ binding site [ion binding]; other site 637887005114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637887005115 nucleotide binding region [chemical binding]; other site 637887005116 ATP-binding site [chemical binding]; other site 637887005117 TM2 domain; Region: TM2; pfam05154 637887005118 multiple promoter invertase; Provisional; Region: mpi; PRK13413 637887005119 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637887005120 catalytic residues [active] 637887005121 catalytic nucleophile [active] 637887005122 Presynaptic Site I dimer interface [polypeptide binding]; other site 637887005123 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637887005124 Synaptic Flat tetramer interface [polypeptide binding]; other site 637887005125 Synaptic Site I dimer interface [polypeptide binding]; other site 637887005126 DNA binding site [nucleotide binding] 637887005127 Homeodomain-like domain; Region: HTH_23; cl17451 637887005128 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 637887005129 Helix-turn-helix domain; Region: HTH_17; pfam12728 637887005130 Transposase; Region: HTH_Tnp_1; pfam01527 637887005131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887005132 HTH-like domain; Region: HTH_21; pfam13276 637887005133 Integrase core domain; Region: rve; pfam00665 637887005134 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887005135 Integrase core domain; Region: rve_3; pfam13683 637887005136 Helix-turn-helix domain; Region: HTH_36; pfam13730 637887005137 Protein of unknown function (DUF503); Region: DUF503; pfam04456 637887005138 Response regulator receiver domain; Region: Response_reg; pfam00072 637887005139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887005140 active site 637887005141 phosphorylation site [posttranslational modification] 637887005142 intermolecular recognition site; other site 637887005143 dimerization interface [polypeptide binding]; other site 637887005144 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 637887005145 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637887005146 PAS domain; Region: PAS_9; pfam13426 637887005147 putative active site [active] 637887005148 heme pocket [chemical binding]; other site 637887005149 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 637887005150 GAF domain; Region: GAF_3; pfam13492 637887005151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887005152 dimer interface [polypeptide binding]; other site 637887005153 phosphorylation site [posttranslational modification] 637887005154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887005155 ATP binding site [chemical binding]; other site 637887005156 Mg2+ binding site [ion binding]; other site 637887005157 G-X-G motif; other site 637887005158 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 637887005159 Domain of unknown function (DUF814); Region: DUF814; pfam05670 637887005160 aspartate aminotransferase; Provisional; Region: PRK06836 637887005161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887005162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887005163 homodimer interface [polypeptide binding]; other site 637887005164 catalytic residue [active] 637887005165 NAD(P)H:flavin oxidoreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151 637887005166 putative FMN binding site [chemical binding]; other site 637887005167 endoglucanase; Region: PLN02420 637887005168 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887005169 Cellulose binding domain; Region: CBM_3; smart01067 637887005170 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005171 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005172 Thiamine pyrophosphokinase; Region: TPK; cd07995 637887005173 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 637887005174 active site 637887005175 dimerization interface [polypeptide binding]; other site 637887005176 thiamine binding site [chemical binding]; other site 637887005177 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637887005178 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 637887005179 substrate binding site [chemical binding]; other site 637887005180 hexamer interface [polypeptide binding]; other site 637887005181 metal binding site [ion binding]; metal-binding site 637887005182 GTPase RsgA; Reviewed; Region: PRK00098 637887005183 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 637887005184 RNA binding site [nucleotide binding]; other site 637887005185 homodimer interface [polypeptide binding]; other site 637887005186 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 637887005187 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637887005188 GTP/Mg2+ binding site [chemical binding]; other site 637887005189 G4 box; other site 637887005190 G5 box; other site 637887005191 G1 box; other site 637887005192 Switch I region; other site 637887005193 G2 box; other site 637887005194 G3 box; other site 637887005195 Switch II region; other site 637887005196 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637887005197 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 637887005198 active site 637887005199 ATP binding site [chemical binding]; other site 637887005200 substrate binding site [chemical binding]; other site 637887005201 activation loop (A-loop); other site 637887005202 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 637887005203 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 637887005204 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 637887005205 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 637887005206 active site 637887005207 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 637887005208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887005209 FeS/SAM binding site; other site 637887005210 16S rRNA methyltransferase B; Provisional; Region: PRK14902 637887005211 NusB family; Region: NusB; pfam01029 637887005212 putative RNA binding site [nucleotide binding]; other site 637887005213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887005214 S-adenosylmethionine binding site [chemical binding]; other site 637887005215 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 637887005216 Protein of unknown function DUF116; Region: DUF116; pfam01976 637887005217 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 637887005218 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 637887005219 putative active site [active] 637887005220 substrate binding site [chemical binding]; other site 637887005221 putative cosubstrate binding site; other site 637887005222 catalytic site [active] 637887005223 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 637887005224 substrate binding site [chemical binding]; other site 637887005225 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 637887005226 active site 637887005227 catalytic residues [active] 637887005228 metal binding site [ion binding]; metal-binding site 637887005229 primosome assembly protein PriA; Validated; Region: PRK05580 637887005230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887005231 ATP binding site [chemical binding]; other site 637887005232 putative Mg++ binding site [ion binding]; other site 637887005233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637887005234 ATP-binding site [chemical binding]; other site 637887005235 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 637887005236 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637887005237 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637887005238 substrate binding pocket [chemical binding]; other site 637887005239 chain length determination region; other site 637887005240 substrate-Mg2+ binding site; other site 637887005241 catalytic residues [active] 637887005242 aspartate-rich region 1; other site 637887005243 active site lid residues [active] 637887005244 aspartate-rich region 2; other site 637887005245 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 637887005246 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 637887005247 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 637887005248 ApbE family; Region: ApbE; pfam02424 637887005249 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637887005250 single-stranded DNA-binding protein; Provisional; Region: PRK05813 637887005251 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 637887005252 generic binding surface II; other site 637887005253 generic binding surface I; other site 637887005254 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637887005255 dimer interface [polypeptide binding]; other site 637887005256 ssDNA binding site [nucleotide binding]; other site 637887005257 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637887005258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887005259 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 637887005260 NodB motif; other site 637887005261 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 637887005262 active site 637887005263 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 637887005264 dimer interface [polypeptide binding]; other site 637887005265 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 637887005266 Ligand Binding Site [chemical binding]; other site 637887005267 Molecular Tunnel; other site 637887005268 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 637887005269 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 637887005270 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 637887005271 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 637887005272 dimerization interface [polypeptide binding]; other site 637887005273 ATP binding site [chemical binding]; other site 637887005274 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 637887005275 dimerization interface [polypeptide binding]; other site 637887005276 ATP binding site [chemical binding]; other site 637887005277 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 637887005278 putative active site [active] 637887005279 catalytic triad [active] 637887005280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637887005281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637887005282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637887005283 dimerization interface [polypeptide binding]; other site 637887005284 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637887005285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637887005286 non-specific DNA binding site [nucleotide binding]; other site 637887005287 salt bridge; other site 637887005288 sequence-specific DNA binding site [nucleotide binding]; other site 637887005289 Cupin domain; Region: Cupin_2; pfam07883 637887005290 Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; Region: MACS_AAE_MA_like; cd05970 637887005291 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 637887005292 active site 637887005293 acyl-activating enzyme (AAE) consensus motif; other site 637887005294 putative CoA binding site [chemical binding]; other site 637887005295 AMP binding site [chemical binding]; other site 637887005296 heat shock protein 90; Provisional; Region: PRK05218 637887005297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887005298 ATP binding site [chemical binding]; other site 637887005299 Mg2+ binding site [ion binding]; other site 637887005300 G-X-G motif; other site 637887005301 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637887005302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637887005303 ABC-ATPase subunit interface; other site 637887005304 dimer interface [polypeptide binding]; other site 637887005305 putative PBP binding regions; other site 637887005306 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 637887005307 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 637887005308 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 637887005309 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 637887005310 metal binding site [ion binding]; metal-binding site 637887005311 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637887005312 metal binding site 2 [ion binding]; metal-binding site 637887005313 putative DNA binding helix; other site 637887005314 metal binding site 1 [ion binding]; metal-binding site 637887005315 dimer interface [polypeptide binding]; other site 637887005316 structural Zn2+ binding site [ion binding]; other site 637887005317 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 637887005318 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 637887005319 Protein phosphatase 2C; Region: PP2C; pfam00481 637887005320 active site 637887005321 endoglucanase; Region: PLN02308 637887005322 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887005323 Cellulose binding domain; Region: CBM_3; pfam00942 637887005324 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005325 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005326 Protein of unknown function DUF45; Region: DUF45; pfam01863 637887005327 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637887005328 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637887005329 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 637887005330 active site 637887005331 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637887005332 FtsX-like permease family; Region: FtsX; pfam02687 637887005333 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637887005334 FtsX-like permease family; Region: FtsX; pfam02687 637887005335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887005336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887005337 Walker A/P-loop; other site 637887005338 ATP binding site [chemical binding]; other site 637887005339 Q-loop/lid; other site 637887005340 ABC transporter signature motif; other site 637887005341 Walker B; other site 637887005342 D-loop; other site 637887005343 H-loop/switch region; other site 637887005344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887005345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887005346 dimer interface [polypeptide binding]; other site 637887005347 phosphorylation site [posttranslational modification] 637887005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887005349 ATP binding site [chemical binding]; other site 637887005350 Mg2+ binding site [ion binding]; other site 637887005351 G-X-G motif; other site 637887005352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887005353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887005354 active site 637887005355 phosphorylation site [posttranslational modification] 637887005356 intermolecular recognition site; other site 637887005357 dimerization interface [polypeptide binding]; other site 637887005358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887005359 DNA binding site [nucleotide binding] 637887005360 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 637887005361 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887005362 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005363 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005364 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 637887005365 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 637887005366 putative active site [active] 637887005367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887005368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887005369 Walker A/P-loop; other site 637887005370 ATP binding site [chemical binding]; other site 637887005371 Q-loop/lid; other site 637887005372 ABC transporter signature motif; other site 637887005373 Walker B; other site 637887005374 D-loop; other site 637887005375 H-loop/switch region; other site 637887005376 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 637887005377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887005378 FeS/SAM binding site; other site 637887005379 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637887005380 Tetratricopeptide repeat; Region: TPR_16; pfam13432 637887005381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005382 TPR motif; other site 637887005383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005384 TPR motif; other site 637887005385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887005386 binding surface 637887005387 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 637887005388 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 637887005389 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887005390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637887005391 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887005392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887005393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887005394 dimer interface [polypeptide binding]; other site 637887005395 phosphorylation site [posttranslational modification] 637887005396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887005397 ATP binding site [chemical binding]; other site 637887005398 Mg2+ binding site [ion binding]; other site 637887005399 G-X-G motif; other site 637887005400 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 637887005401 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 637887005402 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 637887005403 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 637887005404 active site 637887005405 catalytic site [active] 637887005406 substrate binding site [chemical binding]; other site 637887005407 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 637887005408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887005409 FeS/SAM binding site; other site 637887005410 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 637887005411 Pyruvate formate lyase 1; Region: PFL1; cd01678 637887005412 coenzyme A binding site [chemical binding]; other site 637887005413 active site 637887005414 catalytic residues [active] 637887005415 glycine loop; other site 637887005416 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 637887005417 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 637887005418 putative active site [active] 637887005419 putative metal binding site [ion binding]; other site 637887005420 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 637887005421 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 637887005422 YceG-like family; Region: YceG; pfam02618 637887005423 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 637887005424 Protein of unknown function (DUF342); Region: DUF342; pfam03961 637887005425 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 637887005426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887005427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637887005428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887005429 DNA binding residues [nucleotide binding] 637887005430 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 637887005431 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 637887005432 CheC-like family; Region: CheC; pfam04509 637887005433 CheC-like family; Region: CheC; pfam04509 637887005434 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 637887005435 putative CheA interaction surface; other site 637887005436 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 637887005437 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637887005438 putative binding surface; other site 637887005439 active site 637887005440 P2 response regulator binding domain; Region: P2; pfam07194 637887005441 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637887005442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887005443 ATP binding site [chemical binding]; other site 637887005444 Mg2+ binding site [ion binding]; other site 637887005445 G-X-G motif; other site 637887005446 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637887005447 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 637887005448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887005449 active site 637887005450 phosphorylation site [posttranslational modification] 637887005451 intermolecular recognition site; other site 637887005452 dimerization interface [polypeptide binding]; other site 637887005453 CheB methylesterase; Region: CheB_methylest; pfam01339 637887005454 Flagellar protein YcgR; Region: YcgR_2; pfam12945 637887005455 PilZ domain; Region: PilZ; pfam07238 637887005456 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 637887005457 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637887005458 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 637887005459 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 637887005460 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637887005461 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 637887005462 FHIPEP family; Region: FHIPEP; pfam00771 637887005463 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 637887005464 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 637887005465 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 637887005466 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 637887005467 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 637887005468 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 637887005469 Response regulator receiver domain; Region: Response_reg; pfam00072 637887005470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887005471 active site 637887005472 phosphorylation site [posttranslational modification] 637887005473 intermolecular recognition site; other site 637887005474 dimerization interface [polypeptide binding]; other site 637887005475 flagellar motor switch protein; Validated; Region: PRK08119 637887005476 CheC-like family; Region: CheC; pfam04509 637887005477 CheC-like family; Region: CheC; pfam04509 637887005478 flagellar motor switch protein FliN; Region: fliN; TIGR02480 637887005479 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 637887005480 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 637887005481 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 637887005482 Flagellar protein (FlbD); Region: FlbD; pfam06289 637887005483 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 637887005484 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637887005485 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 637887005486 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637887005487 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 637887005488 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 637887005489 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 637887005490 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 637887005491 MgtE intracellular N domain; Region: MgtE_N; cl15244 637887005492 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 637887005493 Flagellar FliJ protein; Region: FliJ; pfam02050 637887005494 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 637887005495 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637887005496 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 637887005497 Walker A motif/ATP binding site; other site 637887005498 Walker B motif; other site 637887005499 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 637887005500 Flagellar assembly protein FliH; Region: FliH; pfam02108 637887005501 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 637887005502 MgtE intracellular N domain; Region: MgtE_N; cl15244 637887005503 FliG C-terminal domain; Region: FliG_C; pfam01706 637887005504 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 637887005505 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 637887005506 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 637887005507 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 637887005508 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 637887005509 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637887005510 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637887005511 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 637887005512 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637887005513 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 637887005514 Glucose inhibited division protein A; Region: GIDA; pfam01134 637887005515 DNA topoisomerase I; Validated; Region: PRK05582 637887005516 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 637887005517 active site 637887005518 interdomain interaction site; other site 637887005519 putative metal-binding site [ion binding]; other site 637887005520 nucleotide binding site [chemical binding]; other site 637887005521 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637887005522 domain I; other site 637887005523 DNA binding groove [nucleotide binding] 637887005524 phosphate binding site [ion binding]; other site 637887005525 domain II; other site 637887005526 domain III; other site 637887005527 nucleotide binding site [chemical binding]; other site 637887005528 catalytic site [active] 637887005529 domain IV; other site 637887005530 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637887005531 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637887005532 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637887005533 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 637887005534 DNA protecting protein DprA; Region: dprA; TIGR00732 637887005535 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 637887005536 active site 637887005537 putative catalytic site [active] 637887005538 DNA binding site [nucleotide binding] 637887005539 putative phosphate binding site [ion binding]; other site 637887005540 metal binding site A [ion binding]; metal-binding site 637887005541 AP binding site [nucleotide binding]; other site 637887005542 metal binding site B [ion binding]; metal-binding site 637887005543 hypothetical protein; Provisional; Region: PRK11770 637887005544 Domain of unknown function (DUF307); Region: DUF307; pfam03733 637887005545 Domain of unknown function (DUF307); Region: DUF307; pfam03733 637887005546 Uncharacterized conserved protein [Function unknown]; Region: COG0432 637887005547 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 637887005548 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 637887005549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887005550 Walker A motif; other site 637887005551 ATP binding site [chemical binding]; other site 637887005552 Walker B motif; other site 637887005553 arginine finger; other site 637887005554 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 637887005555 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887005556 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 637887005557 dockerin binding interface; other site 637887005558 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 637887005559 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 637887005560 ATP cone domain; Region: ATP-cone; pfam03477 637887005561 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 637887005562 sporulation sigma factor SigG; Reviewed; Region: PRK08215 637887005563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887005564 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637887005565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887005566 DNA binding residues [nucleotide binding] 637887005567 sporulation sigma factor SigE; Reviewed; Region: PRK08301 637887005568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887005569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887005570 DNA binding residues [nucleotide binding] 637887005571 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 637887005572 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 637887005573 cell division protein FtsZ; Validated; Region: PRK09330 637887005574 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 637887005575 nucleotide binding site [chemical binding]; other site 637887005576 SulA interaction site; other site 637887005577 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 637887005578 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637887005579 nucleotide binding site [chemical binding]; other site 637887005580 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 637887005581 Cell division protein FtsA; Region: FtsA; pfam14450 637887005582 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 637887005583 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 637887005584 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 637887005585 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 637887005586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887005587 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 637887005588 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 637887005589 catalytic triad [active] 637887005590 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887005591 MULE transposase domain; Region: MULE; pfam10551 637887005592 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005593 TPR repeat; Region: TPR_11; pfam13414 637887005594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005595 binding surface 637887005596 TPR motif; other site 637887005597 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 637887005598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005599 binding surface 637887005600 TPR motif; other site 637887005601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005602 binding surface 637887005603 TPR motif; other site 637887005604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005605 binding surface 637887005606 TPR motif; other site 637887005607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005608 binding surface 637887005609 TPR motif; other site 637887005610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005611 binding surface 637887005612 TPR motif; other site 637887005613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005614 binding surface 637887005615 TPR motif; other site 637887005616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005617 binding surface 637887005618 TPR motif; other site 637887005619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005620 binding surface 637887005621 TPR motif; other site 637887005622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005623 binding surface 637887005624 TPR motif; other site 637887005625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887005626 binding surface 637887005627 TPR motif; other site 637887005628 TPR repeat; Region: TPR_11; pfam13414 637887005629 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005630 hypothetical protein; Provisional; Region: PRK06851 637887005631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887005632 Walker A motif; other site 637887005633 ATP binding site [chemical binding]; other site 637887005634 endoglucanase; Region: PLN02420 637887005635 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887005636 Cellulose binding domain; Region: CBM_3; cl03026 637887005637 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005638 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005639 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 637887005640 dimer interface [polypeptide binding]; other site 637887005641 [2Fe-2S] cluster binding site [ion binding]; other site 637887005642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637887005643 catalytic loop [active] 637887005644 iron binding site [ion binding]; other site 637887005645 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 637887005646 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 637887005647 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887005648 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 637887005649 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 637887005650 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 637887005651 dimer interface [polypeptide binding]; other site 637887005652 [2Fe-2S] cluster binding site [ion binding]; other site 637887005653 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 637887005654 SLBB domain; Region: SLBB; pfam10531 637887005655 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 637887005656 4Fe-4S binding domain; Region: Fer4; pfam00037 637887005657 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637887005658 4Fe-4S binding domain; Region: Fer4_6; pfam12837 637887005659 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 637887005660 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 637887005661 putative dimer interface [polypeptide binding]; other site 637887005662 [2Fe-2S] cluster binding site [ion binding]; other site 637887005663 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 637887005664 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 637887005665 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 637887005666 Putative Fe-S cluster; Region: FeS; cl17515 637887005667 PAS fold; Region: PAS; pfam00989 637887005668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637887005669 putative active site [active] 637887005670 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 637887005671 dimer interface [polypeptide binding]; other site 637887005672 [2Fe-2S] cluster binding site [ion binding]; other site 637887005673 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637887005674 active site 637887005675 ATP binding site [chemical binding]; other site 637887005676 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 637887005677 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 637887005678 putative catalytic cysteine [active] 637887005679 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 637887005680 putative active site [active] 637887005681 metal binding site [ion binding]; metal-binding site 637887005682 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 637887005683 CoA binding domain; Region: CoA_binding; pfam02629 637887005684 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 637887005685 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 637887005686 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 637887005687 NAD binding site [chemical binding]; other site 637887005688 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637887005689 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637887005690 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637887005691 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 637887005692 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 637887005693 RNase E interface [polypeptide binding]; other site 637887005694 trimer interface [polypeptide binding]; other site 637887005695 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 637887005696 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 637887005697 RNase E interface [polypeptide binding]; other site 637887005698 trimer interface [polypeptide binding]; other site 637887005699 active site 637887005700 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 637887005701 putative nucleic acid binding region [nucleotide binding]; other site 637887005702 G-X-X-G motif; other site 637887005703 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 637887005704 RNA binding site [nucleotide binding]; other site 637887005705 domain interface; other site 637887005706 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 637887005707 16S/18S rRNA binding site [nucleotide binding]; other site 637887005708 S13e-L30e interaction site [polypeptide binding]; other site 637887005709 25S rRNA binding site [nucleotide binding]; other site 637887005710 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 637887005711 CotJB protein; Region: CotJB; pfam12652 637887005712 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 637887005713 dimanganese center [ion binding]; other site 637887005714 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887005715 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 637887005716 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887005717 Cellulose binding domain; Region: CBM_3; pfam00942 637887005718 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005719 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005720 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887005721 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 637887005722 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887005723 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005724 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005725 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 637887005726 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 637887005727 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637887005728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887005729 substrate binding pocket [chemical binding]; other site 637887005730 membrane-bound complex binding site; other site 637887005731 hinge residues; other site 637887005732 PAS domain; Region: PAS; smart00091 637887005733 PAS fold; Region: PAS; pfam00989 637887005734 putative active site [active] 637887005735 heme pocket [chemical binding]; other site 637887005736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887005737 metal binding site [ion binding]; metal-binding site 637887005738 active site 637887005739 I-site; other site 637887005740 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637887005741 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 637887005742 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 637887005743 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 637887005744 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887005745 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005746 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887005747 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887005748 Cellulose binding domain; Region: CBM_3; pfam00942 637887005749 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887005750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887005751 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887005752 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887005753 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887005754 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 637887005755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887005756 dimerization interface [polypeptide binding]; other site 637887005757 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887005758 dimer interface [polypeptide binding]; other site 637887005759 putative CheW interface [polypeptide binding]; other site 637887005760 Repair protein; Region: Repair_PSII; pfam04536 637887005761 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 637887005762 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637887005763 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887005764 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637887005765 Walker A/P-loop; other site 637887005766 ATP binding site [chemical binding]; other site 637887005767 Q-loop/lid; other site 637887005768 ABC transporter signature motif; other site 637887005769 Walker B; other site 637887005770 D-loop; other site 637887005771 H-loop/switch region; other site 637887005772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637887005773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887005774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887005775 Walker A/P-loop; other site 637887005776 ATP binding site [chemical binding]; other site 637887005777 Q-loop/lid; other site 637887005778 ABC transporter signature motif; other site 637887005779 Walker B; other site 637887005780 D-loop; other site 637887005781 H-loop/switch region; other site 637887005782 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 637887005783 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637887005784 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 637887005785 putative active site [active] 637887005786 metal binding site [ion binding]; metal-binding site 637887005787 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 637887005788 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637887005789 ligand binding site [chemical binding]; other site 637887005790 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637887005791 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637887005792 TM-ABC transporter signature motif; other site 637887005793 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637887005794 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637887005795 Walker A/P-loop; other site 637887005796 ATP binding site [chemical binding]; other site 637887005797 Q-loop/lid; other site 637887005798 ABC transporter signature motif; other site 637887005799 Walker B; other site 637887005800 D-loop; other site 637887005801 H-loop/switch region; other site 637887005802 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637887005803 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 637887005804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 637887005805 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 637887005806 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 637887005807 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637887005808 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 637887005809 putative substrate binding site [chemical binding]; other site 637887005810 putative ATP binding site [chemical binding]; other site 637887005811 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 637887005812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637887005813 putative NAD(P) binding site [chemical binding]; other site 637887005814 catalytic Zn binding site [ion binding]; other site 637887005815 structural Zn binding site [ion binding]; other site 637887005816 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887005817 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887005818 Walker A/P-loop; other site 637887005819 ATP binding site [chemical binding]; other site 637887005820 Q-loop/lid; other site 637887005821 ABC transporter signature motif; other site 637887005822 Walker B; other site 637887005823 D-loop; other site 637887005824 H-loop/switch region; other site 637887005825 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 637887005826 Penicillinase repressor; Region: Pencillinase_R; pfam03965 637887005827 GMP synthase; Reviewed; Region: guaA; PRK00074 637887005828 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 637887005829 AMP/PPi binding site [chemical binding]; other site 637887005830 candidate oxyanion hole; other site 637887005831 catalytic triad [active] 637887005832 potential glutamine specificity residues [chemical binding]; other site 637887005833 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 637887005834 ATP Binding subdomain [chemical binding]; other site 637887005835 Ligand Binding sites [chemical binding]; other site 637887005836 Dimerization subdomain; other site 637887005837 glutamate dehydrogenase; Provisional; Region: PRK09414 637887005838 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 637887005839 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 637887005840 NAD(P) binding site [chemical binding]; other site 637887005841 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 637887005842 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 637887005843 FAD binding pocket [chemical binding]; other site 637887005844 FAD binding motif [chemical binding]; other site 637887005845 phosphate binding motif [ion binding]; other site 637887005846 beta-alpha-beta structure motif; other site 637887005847 NAD binding pocket [chemical binding]; other site 637887005848 Iron coordination center [ion binding]; other site 637887005849 putative oxidoreductase; Provisional; Region: PRK12831 637887005850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637887005851 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887005852 MULE transposase domain; Region: MULE; pfam10551 637887005853 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 637887005854 Protein of unknown function DUF111; Region: DUF111; pfam01969 637887005855 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 637887005856 AIR carboxylase; Region: AIRC; smart01001 637887005857 Uncharacterized conserved protein [Function unknown]; Region: COG5495 637887005858 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 637887005859 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 637887005860 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887005861 peptide chain release factor 2; Validated; Region: prfB; PRK00578 637887005862 PCRF domain; Region: PCRF; pfam03462 637887005863 RF-1 domain; Region: RF-1; pfam00472 637887005864 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637887005865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637887005866 non-specific DNA binding site [nucleotide binding]; other site 637887005867 salt bridge; other site 637887005868 sequence-specific DNA binding site [nucleotide binding]; other site 637887005869 hypothetical protein; Validated; Region: PRK07682 637887005870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637887005871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887005872 homodimer interface [polypeptide binding]; other site 637887005873 catalytic residue [active] 637887005874 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 637887005875 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 637887005876 AsnC family; Region: AsnC_trans_reg; pfam01037 637887005877 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637887005878 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637887005879 catalytic residues [active] 637887005880 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887005881 MULE transposase domain; Region: MULE; pfam10551 637887005882 Transposase; Region: HTH_Tnp_1; pfam01527 637887005883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887005884 HTH-like domain; Region: HTH_21; pfam13276 637887005885 Integrase core domain; Region: rve; pfam00665 637887005886 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887005887 Integrase core domain; Region: rve_3; pfam13683 637887005888 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 637887005889 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 637887005890 putative homodimer interface [polypeptide binding]; other site 637887005891 putative active site pocket [active] 637887005892 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 637887005893 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887005894 MULE transposase domain; Region: MULE; pfam10551 637887005895 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 637887005896 PHP-associated; Region: PHP_C; pfam13263 637887005897 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 637887005898 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 637887005899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 637887005900 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 637887005901 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 637887005902 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 637887005903 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637887005904 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637887005905 Catalytic site [active] 637887005906 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 637887005907 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 637887005908 intersubunit interface [polypeptide binding]; other site 637887005909 active site 637887005910 zinc binding site [ion binding]; other site 637887005911 Na+ binding site [ion binding]; other site 637887005912 6-phosphofructokinase; Provisional; Region: PRK14072 637887005913 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 637887005914 active site 637887005915 ADP/pyrophosphate binding site [chemical binding]; other site 637887005916 dimerization interface [polypeptide binding]; other site 637887005917 allosteric effector site; other site 637887005918 fructose-1,6-bisphosphate binding site; other site 637887005919 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637887005920 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 637887005921 NAD binding site [chemical binding]; other site 637887005922 dimer interface [polypeptide binding]; other site 637887005923 substrate binding site [chemical binding]; other site 637887005924 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637887005925 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637887005926 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 637887005927 putative NAD(P) binding site [chemical binding]; other site 637887005928 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 637887005929 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637887005930 catalytic loop [active] 637887005931 iron binding site [ion binding]; other site 637887005932 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 637887005933 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 637887005934 4Fe-4S binding domain; Region: Fer4; pfam00037 637887005935 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 637887005936 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 637887005937 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 637887005938 dimer interface [polypeptide binding]; other site 637887005939 [2Fe-2S] cluster binding site [ion binding]; other site 637887005940 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 637887005941 SLBB domain; Region: SLBB; pfam10531 637887005942 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 637887005943 4Fe-4S binding domain; Region: Fer4; pfam00037 637887005944 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 637887005945 4Fe-4S binding domain; Region: Fer4; pfam00037 637887005946 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 637887005947 dimer interface [polypeptide binding]; other site 637887005948 [2Fe-2S] cluster binding site [ion binding]; other site 637887005949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887005950 ATP binding site [chemical binding]; other site 637887005951 Mg2+ binding site [ion binding]; other site 637887005952 G-X-G motif; other site 637887005953 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 637887005954 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 637887005955 putative dimer interface [polypeptide binding]; other site 637887005956 [2Fe-2S] cluster binding site [ion binding]; other site 637887005957 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 637887005958 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 637887005959 active site 637887005960 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 637887005961 DRTGG domain; Region: DRTGG; pfam07085 637887005962 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 637887005963 4Fe-4S binding domain; Region: Fer4_6; pfam12837 637887005964 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 637887005965 Putative Fe-S cluster; Region: FeS; cl17515 637887005966 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 637887005967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887005968 ATP binding site [chemical binding]; other site 637887005969 Mg2+ binding site [ion binding]; other site 637887005970 G-X-G motif; other site 637887005971 DRTGG domain; Region: DRTGG; pfam07085 637887005972 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 637887005973 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 637887005974 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 637887005975 active site 637887005976 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637887005977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 637887005978 putative dimer interface [polypeptide binding]; other site 637887005979 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 637887005980 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 637887005981 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 637887005982 G1 box; other site 637887005983 putative GEF interaction site [polypeptide binding]; other site 637887005984 GTP/Mg2+ binding site [chemical binding]; other site 637887005985 Switch I region; other site 637887005986 G2 box; other site 637887005987 G3 box; other site 637887005988 Switch II region; other site 637887005989 G4 box; other site 637887005990 G5 box; other site 637887005991 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 637887005992 S-layer homology domain; Region: SLH; pfam00395 637887005993 S-layer homology domain; Region: SLH; pfam00395 637887005994 S-layer homology domain; Region: SLH; pfam00395 637887005995 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887005996 NAD synthetase; Reviewed; Region: nadE; PRK02628 637887005997 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 637887005998 multimer interface [polypeptide binding]; other site 637887005999 active site 637887006000 catalytic triad [active] 637887006001 protein interface 1 [polypeptide binding]; other site 637887006002 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 637887006003 homodimer interface [polypeptide binding]; other site 637887006004 NAD binding pocket [chemical binding]; other site 637887006005 ATP binding pocket [chemical binding]; other site 637887006006 Mg binding site [ion binding]; other site 637887006007 active-site loop [active] 637887006008 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 637887006009 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637887006010 HIGH motif; other site 637887006011 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637887006012 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637887006013 active site 637887006014 KMSKS motif; other site 637887006015 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 637887006016 tRNA binding surface [nucleotide binding]; other site 637887006017 anticodon binding site; other site 637887006018 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 637887006019 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 637887006020 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 637887006021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887006022 TPR motif; other site 637887006023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887006024 binding surface 637887006025 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 637887006026 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 637887006027 intersubunit interface [polypeptide binding]; other site 637887006028 active site 637887006029 Zn2+ binding site [ion binding]; other site 637887006030 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637887006031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 637887006032 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887006033 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887006034 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 637887006035 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 637887006036 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887006037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887006038 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 637887006039 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637887006040 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637887006041 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 637887006042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887006043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637887006044 Walker A motif; other site 637887006045 ATP binding site [chemical binding]; other site 637887006046 Walker B motif; other site 637887006047 arginine finger; other site 637887006048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887006049 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637887006050 Walker A motif; other site 637887006051 ATP binding site [chemical binding]; other site 637887006052 Walker B motif; other site 637887006053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637887006054 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 637887006055 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637887006056 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 637887006057 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637887006058 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637887006059 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 637887006060 3D domain; Region: 3D; pfam06725 637887006061 excinuclease ABC subunit B; Provisional; Region: PRK05298 637887006062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887006063 ATP binding site [chemical binding]; other site 637887006064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637887006065 nucleotide binding region [chemical binding]; other site 637887006066 ATP-binding site [chemical binding]; other site 637887006067 Ultra-violet resistance protein B; Region: UvrB; pfam12344 637887006068 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 637887006069 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 637887006070 CAP-like domain; other site 637887006071 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 637887006072 active site 637887006073 primary dimer interface [polypeptide binding]; other site 637887006074 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 637887006075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637887006076 Mg2+ binding site [ion binding]; other site 637887006077 G-X-G motif; other site 637887006078 DNA gyrase B; Region: DNA_gyraseB; pfam00204 637887006079 ATP binding site [chemical binding]; other site 637887006080 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 637887006081 active site 637887006082 metal binding site [ion binding]; metal-binding site 637887006083 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637887006084 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 637887006085 Uncharacterized conserved protein [Function unknown]; Region: COG2966 637887006086 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 637887006087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887006088 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 637887006089 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 637887006090 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 637887006091 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637887006092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887006093 dimerization interface [polypeptide binding]; other site 637887006094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 637887006095 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887006096 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887006097 dimer interface [polypeptide binding]; other site 637887006098 putative CheW interface [polypeptide binding]; other site 637887006099 conserved hypothetical integral membrane protein; Region: TIGR03766 637887006100 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 637887006101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637887006102 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637887006103 catalytic residue [active] 637887006104 Transposase; Region: HTH_Tnp_1; pfam01527 637887006105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887006106 HTH-like domain; Region: HTH_21; pfam13276 637887006107 Integrase core domain; Region: rve; pfam00665 637887006108 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887006109 Integrase core domain; Region: rve_3; pfam13683 637887006110 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 637887006111 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 637887006112 catalytic residues [active] 637887006113 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 637887006114 homoserine dehydrogenase; Provisional; Region: PRK06349 637887006115 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 637887006116 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637887006117 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 637887006118 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 637887006119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637887006120 DEAD_2; Region: DEAD_2; pfam06733 637887006121 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 637887006122 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 637887006123 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 637887006124 Response regulator receiver domain; Region: Response_reg; pfam00072 637887006125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887006126 active site 637887006127 phosphorylation site [posttranslational modification] 637887006128 intermolecular recognition site; other site 637887006129 dimerization interface [polypeptide binding]; other site 637887006130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887006131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887006132 dimer interface [polypeptide binding]; other site 637887006133 phosphorylation site [posttranslational modification] 637887006134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887006135 ATP binding site [chemical binding]; other site 637887006136 Mg2+ binding site [ion binding]; other site 637887006137 G-X-G motif; other site 637887006138 isocitrate dehydrogenase; Validated; Region: PRK08299 637887006139 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 637887006140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887006141 Walker A motif; other site 637887006142 ATP binding site [chemical binding]; other site 637887006143 Walker B motif; other site 637887006144 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637887006145 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637887006146 active site 637887006147 catalytic tetrad [active] 637887006148 glycogen synthase; Provisional; Region: glgA; PRK00654 637887006149 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 637887006150 ADP-binding pocket [chemical binding]; other site 637887006151 homodimer interface [polypeptide binding]; other site 637887006152 Coat F domain; Region: Coat_F; pfam07875 637887006153 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637887006154 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637887006155 active site 637887006156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887006157 S-adenosylmethionine binding site [chemical binding]; other site 637887006158 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 637887006159 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 637887006160 putative ligand binding site [chemical binding]; other site 637887006161 putative NAD binding site [chemical binding]; other site 637887006162 catalytic site [active] 637887006163 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 637887006164 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 637887006165 catalytic domain interface [polypeptide binding]; other site 637887006166 homodimer interface [polypeptide binding]; other site 637887006167 putative active site [active] 637887006168 endoglucanase; Region: PLN02308 637887006169 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887006170 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887006172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887006173 metal binding site [ion binding]; metal-binding site 637887006174 active site 637887006175 I-site; other site 637887006176 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887006177 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887006178 Zn2+ binding site [ion binding]; other site 637887006179 Mg2+ binding site [ion binding]; other site 637887006180 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637887006181 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637887006182 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637887006183 Cellulose binding domain; Region: CBM_3; pfam00942 637887006184 Glyco_18 domain; Region: Glyco_18; smart00636 637887006185 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637887006186 active site 637887006187 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006188 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006189 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 637887006190 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006191 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887006192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887006193 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887006194 Cellulose binding domain; Region: CBM_3; pfam00942 637887006195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887006196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887006197 dimer interface [polypeptide binding]; other site 637887006198 putative CheW interface [polypeptide binding]; other site 637887006199 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 637887006200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637887006201 catalytic residue [active] 637887006202 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 637887006203 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 637887006204 putative catalytic cysteine [active] 637887006205 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637887006206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887006207 motif II; other site 637887006208 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887006209 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 637887006210 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637887006211 Rhomboid family; Region: Rhomboid; cl11446 637887006212 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006213 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006214 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 637887006215 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 637887006216 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 637887006217 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 637887006218 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 637887006219 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 637887006220 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 637887006221 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 637887006222 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 637887006223 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637887006224 Walker A motif; other site 637887006225 ATP binding site [chemical binding]; other site 637887006226 Walker B motif; other site 637887006227 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637887006228 dimerization interface [polypeptide binding]; other site 637887006229 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637887006230 ligand binding site [chemical binding]; other site 637887006231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887006232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887006233 ATP binding site [chemical binding]; other site 637887006234 Mg2+ binding site [ion binding]; other site 637887006235 G-X-G motif; other site 637887006236 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 637887006237 Protein of unknown function DUF58; Region: DUF58; pfam01882 637887006238 MoxR-like ATPases [General function prediction only]; Region: COG0714 637887006239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887006240 Walker A motif; other site 637887006241 ATP binding site [chemical binding]; other site 637887006242 Walker B motif; other site 637887006243 arginine finger; other site 637887006244 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 637887006245 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 637887006246 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 637887006247 Clostripain family; Region: Peptidase_C11; pfam03415 637887006248 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 637887006249 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637887006250 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 637887006251 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 637887006252 Walker A/P-loop; other site 637887006253 ATP binding site [chemical binding]; other site 637887006254 Q-loop/lid; other site 637887006255 ABC transporter signature motif; other site 637887006256 Walker B; other site 637887006257 D-loop; other site 637887006258 H-loop/switch region; other site 637887006259 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006260 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 637887006261 Ca binding site [ion binding]; other site 637887006262 Ca binding site (active) [ion binding]; other site 637887006263 ligand binding site [chemical binding]; other site 637887006264 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 637887006265 metal binding site [ion binding]; metal-binding site 637887006266 active site 637887006267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637887006268 dimerization interface [polypeptide binding]; other site 637887006269 putative DNA binding site [nucleotide binding]; other site 637887006270 putative Zn2+ binding site [ion binding]; other site 637887006271 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637887006272 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637887006273 metal-binding site [ion binding] 637887006274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637887006275 Soluble P-type ATPase [General function prediction only]; Region: COG4087 637887006276 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887006277 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637887006278 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 637887006279 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 637887006280 putative metal binding residues [ion binding]; other site 637887006281 signature motif; other site 637887006282 dimer interface [polypeptide binding]; other site 637887006283 active site 637887006284 polyP binding site; other site 637887006285 substrate binding site [chemical binding]; other site 637887006286 acceptor-phosphate pocket; other site 637887006287 Lamin Tail Domain; Region: LTD; pfam00932 637887006288 Lamin Tail Domain; Region: LTD; pfam00932 637887006289 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 637887006290 CotH protein; Region: CotH; pfam08757 637887006291 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006292 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006293 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 637887006294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637887006295 active site 637887006296 catalytic tetrad [active] 637887006297 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 637887006298 catalytic residues [active] 637887006299 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 637887006300 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637887006301 DNA interaction; other site 637887006302 Metal-binding active site; metal-binding site 637887006303 AMP-binding domain protein; Validated; Region: PRK08315 637887006304 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637887006305 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 637887006306 acyl-activating enzyme (AAE) consensus motif; other site 637887006307 acyl-activating enzyme (AAE) consensus motif; other site 637887006308 putative AMP binding site [chemical binding]; other site 637887006309 putative active site [active] 637887006310 putative CoA binding site [chemical binding]; other site 637887006311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637887006312 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637887006313 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 637887006314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887006315 FeS/SAM binding site; other site 637887006316 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637887006317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637887006318 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 637887006319 putative NAD(P) binding site [chemical binding]; other site 637887006320 active site 637887006321 putative substrate binding site [chemical binding]; other site 637887006322 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 637887006323 Part of AAA domain; Region: AAA_19; pfam13245 637887006324 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 637887006325 Family description; Region: UvrD_C_2; pfam13538 637887006326 AAA ATPase domain; Region: AAA_15; pfam13175 637887006327 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 637887006328 putative active site [active] 637887006329 putative metal-binding site [ion binding]; other site 637887006330 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 637887006331 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887006332 MULE transposase domain; Region: MULE; pfam10551 637887006333 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 637887006334 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637887006335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637887006336 putative active site [active] 637887006337 putative metal binding site [ion binding]; other site 637887006338 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 637887006339 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 637887006340 active site 637887006341 dimer interface [polypeptide binding]; other site 637887006342 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 637887006343 dimer interface [polypeptide binding]; other site 637887006344 active site 637887006345 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637887006346 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 637887006347 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637887006348 putative tRNA-binding site [nucleotide binding]; other site 637887006349 B3/4 domain; Region: B3_4; pfam03483 637887006350 tRNA synthetase B5 domain; Region: B5; smart00874 637887006351 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 637887006352 dimer interface [polypeptide binding]; other site 637887006353 motif 1; other site 637887006354 motif 3; other site 637887006355 motif 2; other site 637887006356 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 637887006357 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 637887006358 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 637887006359 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 637887006360 dimer interface [polypeptide binding]; other site 637887006361 motif 1; other site 637887006362 active site 637887006363 motif 2; other site 637887006364 motif 3; other site 637887006365 Protein of unknown function (DUF975); Region: DUF975; cl10504 637887006366 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 637887006367 beta-galactosidase; Region: BGL; TIGR03356 637887006368 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 637887006369 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 637887006370 active site 637887006371 active site 637887006372 catalytic residues [active] 637887006373 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006374 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637887006376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637887006377 DNA binding site [nucleotide binding] 637887006378 domain linker motif; other site 637887006379 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637887006380 ligand binding site [chemical binding]; other site 637887006381 dimerization interface [polypeptide binding]; other site 637887006382 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637887006383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637887006384 active site 637887006385 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 637887006386 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 637887006387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637887006388 ATP binding site [chemical binding]; other site 637887006389 putative Mg++ binding site [ion binding]; other site 637887006390 Family description; Region: UvrD_C_2; pfam13538 637887006391 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 637887006392 ANTAR domain; Region: ANTAR; pfam03861 637887006393 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 637887006394 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 637887006395 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637887006396 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 637887006397 putative subunit interface; other site 637887006398 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 637887006399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637887006400 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 637887006401 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887006402 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 637887006403 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 637887006404 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 637887006405 active site 637887006406 FMN binding site [chemical binding]; other site 637887006407 substrate binding site [chemical binding]; other site 637887006408 3Fe-4S cluster binding site [ion binding]; other site 637887006409 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 637887006410 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 637887006411 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 637887006412 putative active site [active] 637887006413 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 637887006414 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 637887006415 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637887006416 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 637887006417 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887006418 Interdomain contacts; other site 637887006419 Cytokine receptor motif; other site 637887006420 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006421 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006422 serpin-like protein; Provisional; Region: PHA02660 637887006423 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 637887006424 reactive center loop; other site 637887006425 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 637887006426 Interdomain contacts; other site 637887006427 Cytokine receptor motif; other site 637887006428 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006429 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006430 serpin-like protein; Provisional; Region: PHA02660 637887006431 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 637887006432 reactive center loop; other site 637887006433 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 637887006434 active site 637887006435 dimerization interface [polypeptide binding]; other site 637887006436 ribonuclease PH; Reviewed; Region: rph; PRK00173 637887006437 Ribonuclease PH; Region: RNase_PH_bact; cd11362 637887006438 hexamer interface [polypeptide binding]; other site 637887006439 active site 637887006440 Sporulation and spore germination; Region: Germane; pfam10646 637887006441 Sporulation and spore germination; Region: Germane; pfam10646 637887006442 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 637887006443 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637887006444 NAD binding site [chemical binding]; other site 637887006445 homodimer interface [polypeptide binding]; other site 637887006446 active site 637887006447 substrate binding site [chemical binding]; other site 637887006448 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887006449 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887006450 AMIN domain; Region: AMIN; pfam11741 637887006451 AMIN domain; Region: AMIN; pfam11741 637887006452 AMIN domain; Region: AMIN; pfam11741 637887006453 AMIN domain; Region: AMIN; pfam11741 637887006454 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 637887006455 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637887006456 active site 637887006457 metal binding site [ion binding]; metal-binding site 637887006458 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 637887006459 Cell division protein FtsA; Region: FtsA; pfam14450 637887006460 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 637887006461 Ligand Binding Site [chemical binding]; other site 637887006462 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 637887006463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887006464 Walker A motif; other site 637887006465 ATP binding site [chemical binding]; other site 637887006466 Walker B motif; other site 637887006467 arginine finger; other site 637887006468 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 637887006469 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 637887006470 RuvA N terminal domain; Region: RuvA_N; pfam01330 637887006471 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 637887006472 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 637887006473 active site 637887006474 putative DNA-binding cleft [nucleotide binding]; other site 637887006475 dimer interface [polypeptide binding]; other site 637887006476 argininosuccinate synthase; Provisional; Region: PRK13820 637887006477 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 637887006478 ANP binding site [chemical binding]; other site 637887006479 Substrate Binding Site II [chemical binding]; other site 637887006480 Substrate Binding Site I [chemical binding]; other site 637887006481 argininosuccinate lyase; Provisional; Region: PRK00855 637887006482 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 637887006483 active sites [active] 637887006484 tetramer interface [polypeptide binding]; other site 637887006485 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 637887006486 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972 637887006487 putative active site [active] 637887006488 putative metal binding site [ion binding]; other site 637887006489 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637887006490 Sulfatase; Region: Sulfatase; pfam00884 637887006491 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 637887006492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637887006493 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 637887006494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637887006495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887006496 active site 637887006497 phosphorylation site [posttranslational modification] 637887006498 intermolecular recognition site; other site 637887006499 dimerization interface [polypeptide binding]; other site 637887006500 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 637887006501 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 637887006502 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 637887006503 GTPase CgtA; Reviewed; Region: obgE; PRK12297 637887006504 GTP1/OBG; Region: GTP1_OBG; pfam01018 637887006505 Obg GTPase; Region: Obg; cd01898 637887006506 G1 box; other site 637887006507 GTP/Mg2+ binding site [chemical binding]; other site 637887006508 Switch I region; other site 637887006509 G2 box; other site 637887006510 G3 box; other site 637887006511 Switch II region; other site 637887006512 G4 box; other site 637887006513 G5 box; other site 637887006514 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 637887006515 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 637887006516 hypothetical protein; Provisional; Region: PRK14553 637887006517 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 637887006518 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 637887006519 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 637887006520 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 637887006521 homodimer interface [polypeptide binding]; other site 637887006522 oligonucleotide binding site [chemical binding]; other site 637887006523 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 637887006524 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 637887006525 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 637887006526 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 637887006527 B12 binding site [chemical binding]; other site 637887006528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887006529 FeS/SAM binding site; other site 637887006530 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 637887006531 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 637887006532 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 637887006533 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637887006534 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637887006535 active site 637887006536 catalytic tetrad [active] 637887006537 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 637887006538 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637887006539 hypothetical protein; Provisional; Region: PRK05473 637887006540 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 637887006541 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637887006542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887006543 FeS/SAM binding site; other site 637887006544 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637887006545 regulatory protein interface [polypeptide binding]; other site 637887006546 regulatory phosphorylation site [posttranslational modification]; other site 637887006547 Uncharacterized conserved protein [Function unknown]; Region: COG1683 637887006548 ribonuclease R; Region: RNase_R; TIGR02063 637887006549 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 637887006550 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 637887006551 RNB domain; Region: RNB; pfam00773 637887006552 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 637887006553 RNA binding site [nucleotide binding]; other site 637887006554 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887006555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 637887006556 Preprotein translocase SecG subunit; Region: SecG; pfam03840 637887006557 enolase; Provisional; Region: eno; PRK00077 637887006558 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 637887006559 dimer interface [polypeptide binding]; other site 637887006560 metal binding site [ion binding]; metal-binding site 637887006561 substrate binding pocket [chemical binding]; other site 637887006562 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887006563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887006564 metal binding site [ion binding]; metal-binding site 637887006565 active site 637887006566 I-site; other site 637887006567 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887006568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887006569 Zn2+ binding site [ion binding]; other site 637887006570 Mg2+ binding site [ion binding]; other site 637887006571 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 637887006572 phosphoglyceromutase; Provisional; Region: PRK05434 637887006573 triosephosphate isomerase; Provisional; Region: PRK14565 637887006574 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637887006575 substrate binding site [chemical binding]; other site 637887006576 dimer interface [polypeptide binding]; other site 637887006577 catalytic triad [active] 637887006578 Phosphoglycerate kinase; Region: PGK; pfam00162 637887006579 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 637887006580 substrate binding site [chemical binding]; other site 637887006581 hinge regions; other site 637887006582 ADP binding site [chemical binding]; other site 637887006583 catalytic site [active] 637887006584 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 637887006585 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 637887006586 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637887006587 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 637887006588 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 637887006589 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 637887006590 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 637887006591 active site 637887006592 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 637887006593 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637887006594 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 637887006595 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 637887006596 active site 637887006597 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 637887006598 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 637887006599 putative NADP binding site [chemical binding]; other site 637887006600 active site 637887006601 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637887006602 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 637887006603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637887006604 acyl-activating enzyme (AAE) consensus motif; other site 637887006605 AMP binding site [chemical binding]; other site 637887006606 active site 637887006607 CoA binding site [chemical binding]; other site 637887006608 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 637887006609 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637887006610 dimer interface [polypeptide binding]; other site 637887006611 active site 637887006612 CoA binding pocket [chemical binding]; other site 637887006613 acyl carrier protein; Provisional; Region: acpP; PRK00982 637887006614 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 637887006615 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 637887006616 active site 637887006617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887006618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887006619 metal binding site [ion binding]; metal-binding site 637887006620 active site 637887006621 I-site; other site 637887006622 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 637887006623 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887006624 Zn2+ binding site [ion binding]; other site 637887006625 Mg2+ binding site [ion binding]; other site 637887006626 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 637887006627 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 637887006628 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 637887006629 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 637887006630 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 637887006631 stage V sporulation protein AD; Validated; Region: PRK08304 637887006632 stage V sporulation protein AD; Provisional; Region: PRK12404 637887006633 SpoVA protein; Region: SpoVA; cl04298 637887006634 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 637887006635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887006636 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637887006637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887006638 DNA binding residues [nucleotide binding] 637887006639 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 637887006640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887006641 ATP binding site [chemical binding]; other site 637887006642 Mg2+ binding site [ion binding]; other site 637887006643 G-X-G motif; other site 637887006644 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 637887006645 anti sigma factor interaction site; other site 637887006646 regulatory phosphorylation site [posttranslational modification]; other site 637887006647 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637887006648 dimerization domain swap beta strand [polypeptide binding]; other site 637887006649 regulatory protein interface [polypeptide binding]; other site 637887006650 active site 637887006651 regulatory phosphorylation site [posttranslational modification]; other site 637887006652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 637887006653 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 637887006654 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 637887006655 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 637887006656 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 637887006657 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 637887006658 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 637887006659 phosphate binding site [ion binding]; other site 637887006660 putative substrate binding pocket [chemical binding]; other site 637887006661 dimer interface [polypeptide binding]; other site 637887006662 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 637887006663 shikimate kinase; Provisional; Region: PRK13947 637887006664 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 637887006665 FAD binding domain; Region: FAD_binding_4; pfam01565 637887006666 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 637887006667 putative hydrolase; Validated; Region: PRK09248 637887006668 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 637887006669 active site 637887006670 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 637887006671 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 637887006672 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 637887006673 Hpr binding site; other site 637887006674 active site 637887006675 homohexamer subunit interaction site [polypeptide binding]; other site 637887006676 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006677 PilZ domain; Region: PilZ; pfam07238 637887006678 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 637887006679 homopentamer interface [polypeptide binding]; other site 637887006680 active site 637887006681 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 637887006682 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 637887006683 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 637887006684 dimerization interface [polypeptide binding]; other site 637887006685 active site 637887006686 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 637887006687 Lumazine binding domain; Region: Lum_binding; pfam00677 637887006688 Lumazine binding domain; Region: Lum_binding; pfam00677 637887006689 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 637887006690 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 637887006691 catalytic motif [active] 637887006692 Zn binding site [ion binding]; other site 637887006693 RibD C-terminal domain; Region: RibD_C; cl17279 637887006694 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 637887006695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887006696 S-adenosylmethionine binding site [chemical binding]; other site 637887006697 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 637887006698 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 637887006699 dimer interface [polypeptide binding]; other site 637887006700 active site 637887006701 metal binding site [ion binding]; metal-binding site 637887006702 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 637887006703 FAD binding site [chemical binding]; other site 637887006704 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 637887006705 active site 637887006706 Peptidase family M50; Region: Peptidase_M50; pfam02163 637887006707 putative substrate binding region [chemical binding]; other site 637887006708 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 637887006709 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637887006710 Peptidase family M23; Region: Peptidase_M23; pfam01551 637887006711 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 637887006712 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 637887006713 substrate binding site [chemical binding]; other site 637887006714 cell division topological specificity factor MinE; Provisional; Region: PRK13987 637887006715 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 637887006716 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 637887006717 Switch I; other site 637887006718 Switch II; other site 637887006719 septum formation inhibitor; Reviewed; Region: minC; PRK00513 637887006720 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 637887006721 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 637887006722 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637887006723 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637887006724 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637887006725 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637887006726 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 637887006727 rod shape-determining protein MreC; Provisional; Region: PRK13922 637887006728 rod shape-determining protein MreC; Region: MreC; pfam04085 637887006729 rod shape-determining protein MreB; Provisional; Region: PRK13927 637887006730 MreB and similar proteins; Region: MreB_like; cd10225 637887006731 nucleotide binding site [chemical binding]; other site 637887006732 Mg binding site [ion binding]; other site 637887006733 putative protofilament interaction site [polypeptide binding]; other site 637887006734 RodZ interaction site [polypeptide binding]; other site 637887006735 Maf-like protein; Reviewed; Region: PRK00078 637887006736 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 637887006737 active site 637887006738 dimer interface [polypeptide binding]; other site 637887006739 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 637887006740 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 637887006741 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 637887006742 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 637887006743 Found in ATP-dependent protease La (LON); Region: LON; smart00464 637887006744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887006745 Walker A motif; other site 637887006746 ATP binding site [chemical binding]; other site 637887006747 Walker B motif; other site 637887006748 arginine finger; other site 637887006749 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637887006750 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 637887006751 heterotetramer interface [polypeptide binding]; other site 637887006752 active site pocket [active] 637887006753 cleavage site 637887006754 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 637887006755 Putative amidase domain; Region: Amidase_6; pfam12671 637887006756 Probable zinc-binding domain; Region: zf-trcl; pfam13451 637887006757 YtxH-like protein; Region: YtxH; pfam12732 637887006758 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 637887006759 PspC domain; Region: PspC; pfam04024 637887006760 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 637887006761 Cellulose binding domain; Region: CBM_3; pfam00942 637887006762 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 637887006763 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 637887006764 putative dimer interface [polypeptide binding]; other site 637887006765 putative anticodon binding site; other site 637887006766 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 637887006767 homodimer interface [polypeptide binding]; other site 637887006768 motif 1; other site 637887006769 motif 2; other site 637887006770 active site 637887006771 motif 3; other site 637887006772 asparagine synthetase A; Reviewed; Region: PRK06462 637887006773 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 637887006774 dimer interface [polypeptide binding]; other site 637887006775 active site 637887006776 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 637887006777 active site 637887006778 NAD-dependent deacetylase; Provisional; Region: PRK00481 637887006779 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 637887006780 NAD+ binding site [chemical binding]; other site 637887006781 substrate binding site [chemical binding]; other site 637887006782 Zn binding site [ion binding]; other site 637887006783 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 637887006784 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 637887006785 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637887006786 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637887006787 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 637887006788 Rubredoxin; Region: Rubredoxin; pfam00301 637887006789 iron binding site [ion binding]; other site 637887006790 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637887006791 Sulfatase; Region: Sulfatase; pfam00884 637887006792 BioY family; Region: BioY; pfam02632 637887006793 hypothetical protein; Provisional; Region: PRK05590 637887006794 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887006795 Cellulose binding domain; Region: CBM_3; smart01067 637887006796 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887006797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887006798 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 637887006799 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 637887006800 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637887006801 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637887006802 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637887006803 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637887006804 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637887006805 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637887006806 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637887006807 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637887006808 S-layer homology domain; Region: SLH; pfam00395 637887006809 S-layer homology domain; Region: SLH; pfam00395 637887006810 S-layer homology domain; Region: SLH; pfam00395 637887006811 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 637887006812 S-layer homology domain; Region: SLH; pfam00395 637887006813 S-layer homology domain; Region: SLH; pfam00395 637887006814 S-layer homology domain; Region: SLH; pfam00395 637887006815 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 637887006816 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 637887006817 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 637887006818 active site 637887006819 dimer interface [polypeptide binding]; other site 637887006820 effector binding site; other site 637887006821 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637887006822 TSCPD domain; Region: TSCPD; pfam12637 637887006823 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 637887006824 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 637887006825 geranylgeranyl reductase; Region: ChlP; TIGR02028 637887006826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637887006827 non-specific DNA binding site [nucleotide binding]; other site 637887006828 salt bridge; other site 637887006829 sequence-specific DNA binding site [nucleotide binding]; other site 637887006830 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637887006831 Catalytic site [active] 637887006832 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887006833 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887006834 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887006835 CotH protein; Region: CotH; pfam08757 637887006836 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006837 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006838 endoglucanase; Region: PLN02420 637887006839 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887006840 Cellulose binding domain; Region: CBM_3; smart01067 637887006841 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006842 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006843 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 637887006844 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 637887006845 G1 box; other site 637887006846 GTP/Mg2+ binding site [chemical binding]; other site 637887006847 Switch I region; other site 637887006848 G2 box; other site 637887006849 Switch II region; other site 637887006850 G3 box; other site 637887006851 G4 box; other site 637887006852 G5 box; other site 637887006853 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 637887006854 endoglucanase; Region: PLN02420 637887006855 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887006856 Cellulose binding domain; Region: CBM_3; pfam00942 637887006857 Cellulose binding domain; Region: CBM_3; pfam00942 637887006858 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 637887006859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887006860 dimerization interface [polypeptide binding]; other site 637887006861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887006862 dimer interface [polypeptide binding]; other site 637887006863 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 637887006864 putative CheW interface [polypeptide binding]; other site 637887006865 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 637887006866 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 637887006867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887006868 dimerization interface [polypeptide binding]; other site 637887006869 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887006870 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887006871 dimer interface [polypeptide binding]; other site 637887006872 putative CheW interface [polypeptide binding]; other site 637887006873 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 637887006874 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637887006875 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 637887006876 putative dimer interface [polypeptide binding]; other site 637887006877 hybrid cluster protein; Provisional; Region: PRK05290 637887006878 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887006879 ACS interaction site; other site 637887006880 CODH interaction site; other site 637887006881 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 637887006882 hybrid metal cluster; other site 637887006883 4Fe-4S binding domain; Region: Fer4_6; pfam12837 637887006884 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637887006885 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637887006886 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637887006887 ligand binding site [chemical binding]; other site 637887006888 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 637887006889 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 637887006890 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 637887006891 G1 box; other site 637887006892 putative GEF interaction site [polypeptide binding]; other site 637887006893 GTP/Mg2+ binding site [chemical binding]; other site 637887006894 Switch I region; other site 637887006895 G2 box; other site 637887006896 G3 box; other site 637887006897 Switch II region; other site 637887006898 G4 box; other site 637887006899 G5 box; other site 637887006900 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 637887006901 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 637887006902 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 637887006903 YacP-like NYN domain; Region: NYN_YacP; pfam05991 637887006904 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 637887006905 putative metal binding site [ion binding]; other site 637887006906 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 637887006907 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006908 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006909 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 637887006910 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 637887006911 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 637887006912 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637887006913 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 637887006914 inhibitor-cofactor binding pocket; inhibition site 637887006915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887006916 catalytic residue [active] 637887006917 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 637887006918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887006919 S-adenosylmethionine binding site [chemical binding]; other site 637887006920 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 637887006921 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 637887006922 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 637887006923 substrate-cofactor binding pocket; other site 637887006924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887006925 catalytic residue [active] 637887006926 AAA domain; Region: AAA_26; pfam13500 637887006927 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 637887006928 biotin synthase; Region: bioB; TIGR00433 637887006929 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887006930 FeS/SAM binding site; other site 637887006931 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 637887006932 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 637887006933 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 637887006934 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 637887006935 Ferritin-like domain; Region: Ferritin; pfam00210 637887006936 ferroxidase diiron center [ion binding]; other site 637887006937 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 637887006938 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006939 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006940 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 637887006941 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 637887006942 substrate binding site [chemical binding]; other site 637887006943 active site 637887006944 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 637887006945 structural tetrad; other site 637887006946 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887006947 MULE transposase domain; Region: MULE; pfam10551 637887006948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637887006949 non-specific DNA binding site [nucleotide binding]; other site 637887006950 salt bridge; other site 637887006951 sequence-specific DNA binding site [nucleotide binding]; other site 637887006952 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 637887006953 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 637887006954 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 637887006955 catalytic triad [active] 637887006956 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 637887006957 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637887006958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887006959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887006960 DNA binding residues [nucleotide binding] 637887006961 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887006962 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 637887006963 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887006964 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 637887006965 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006966 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887006967 Predicted flavoprotein [General function prediction only]; Region: COG0431 637887006968 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637887006969 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637887006970 trimer interface [polypeptide binding]; other site 637887006971 active site 637887006972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637887006973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637887006974 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 637887006975 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 637887006976 Predicted membrane protein [Function unknown]; Region: COG1511 637887006977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887006978 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637887006979 active site 637887006980 motif I; other site 637887006981 motif II; other site 637887006982 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637887006983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887006984 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 637887006985 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 637887006986 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887006987 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637887006988 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 637887006989 active site 637887006990 8-oxo-dGMP binding site [chemical binding]; other site 637887006991 nudix motif; other site 637887006992 metal binding site [ion binding]; metal-binding site 637887006993 SdpI/YhfL protein family; Region: SdpI; pfam13630 637887006994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887006995 dimerization interface [polypeptide binding]; other site 637887006996 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887006997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887006998 dimer interface [polypeptide binding]; other site 637887006999 putative CheW interface [polypeptide binding]; other site 637887007000 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 637887007001 Predicted transcriptional regulators [Transcription]; Region: COG1695 637887007002 Transcriptional regulator PadR-like family; Region: PadR; cl17335 637887007003 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637887007004 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 637887007005 SCP-2 sterol transfer family; Region: SCP2; cl01225 637887007006 Predicted transcriptional regulators [Transcription]; Region: COG1695 637887007007 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 637887007008 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 637887007009 Predicted membrane protein [Function unknown]; Region: COG2510 637887007010 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 637887007011 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 637887007012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887007013 dimerization interface [polypeptide binding]; other site 637887007014 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 637887007015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887007016 dimer interface [polypeptide binding]; other site 637887007017 putative CheW interface [polypeptide binding]; other site 637887007018 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 637887007019 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 637887007020 Nitrogen regulatory protein P-II; Region: P-II; smart00938 637887007021 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637887007022 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887007023 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 637887007024 Walker A/P-loop; other site 637887007025 ATP binding site [chemical binding]; other site 637887007026 Q-loop/lid; other site 637887007027 ABC transporter signature motif; other site 637887007028 Walker B; other site 637887007029 D-loop; other site 637887007030 H-loop/switch region; other site 637887007031 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637887007032 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637887007033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887007034 Walker A/P-loop; other site 637887007035 ATP binding site [chemical binding]; other site 637887007036 Q-loop/lid; other site 637887007037 ABC transporter signature motif; other site 637887007038 Walker B; other site 637887007039 D-loop; other site 637887007040 H-loop/switch region; other site 637887007041 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637887007042 MarR family; Region: MarR_2; pfam12802 637887007043 MarR family; Region: MarR_2; cl17246 637887007044 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 637887007045 dinuclear metal binding motif [ion binding]; other site 637887007046 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 637887007047 S-layer homology domain; Region: SLH; pfam00395 637887007048 S-layer homology domain; Region: SLH; pfam00395 637887007049 S-layer homology domain; Region: SLH; pfam00395 637887007050 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 637887007051 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 637887007052 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 637887007053 putative active site pocket [active] 637887007054 dimerization interface [polypeptide binding]; other site 637887007055 putative catalytic residue [active] 637887007056 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 637887007057 ArsC family; Region: ArsC; pfam03960 637887007058 putative ArsC-like catalytic residues; other site 637887007059 putative TRX-like catalytic residues [active] 637887007060 Uncharacterized conserved protein [Function unknown]; Region: COG2461 637887007061 Family of unknown function (DUF438); Region: DUF438; pfam04282 637887007062 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 637887007063 Clostridium thermocellum A3DFK9-like, a putative carbohydrate or polyalcohol metabolizing SDR, classical (c) SDRs; Region: A3DFK9-like_SDR_c; cd09761 637887007064 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 637887007065 NAD binding site [chemical binding]; other site 637887007066 active site 637887007067 homodimer interface [polypeptide binding]; other site 637887007068 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637887007069 DNA methylase; Region: N6_N4_Mtase; pfam01555 637887007070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887007071 S-adenosylmethionine binding site [chemical binding]; other site 637887007072 DNA methylase; Region: N6_N4_Mtase; cl17433 637887007073 DpnII restriction endonuclease; Region: DpnII; pfam04556 637887007074 DNA adenine methylase (dam); Region: dam; TIGR00571 637887007075 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 637887007076 diiron binding motif [ion binding]; other site 637887007077 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 637887007078 GTPase RsgA; Reviewed; Region: PRK01889 637887007079 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 637887007080 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637887007081 GTP/Mg2+ binding site [chemical binding]; other site 637887007082 G4 box; other site 637887007083 G5 box; other site 637887007084 G1 box; other site 637887007085 Switch I region; other site 637887007086 G2 box; other site 637887007087 G3 box; other site 637887007088 Switch II region; other site 637887007089 PglZ domain; Region: PglZ; pfam08665 637887007090 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 637887007091 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637887007092 Leucine-rich repeats; other site 637887007093 Substrate binding site [chemical binding]; other site 637887007094 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637887007095 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637887007096 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637887007097 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637887007098 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637887007099 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 637887007100 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 637887007101 putative RNA binding site [nucleotide binding]; other site 637887007102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887007103 S-adenosylmethionine binding site [chemical binding]; other site 637887007104 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007105 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637887007106 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 637887007107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887007108 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 637887007109 putative ADP-binding pocket [chemical binding]; other site 637887007110 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 637887007111 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637887007112 putative acyl-acceptor binding pocket; other site 637887007113 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007114 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887007115 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887007116 Walker A/P-loop; other site 637887007117 ATP binding site [chemical binding]; other site 637887007118 Q-loop/lid; other site 637887007119 ABC transporter signature motif; other site 637887007120 Walker B; other site 637887007121 D-loop; other site 637887007122 H-loop/switch region; other site 637887007123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887007124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887007125 phosphorylation site [posttranslational modification] 637887007126 dimer interface [polypeptide binding]; other site 637887007127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887007128 ATP binding site [chemical binding]; other site 637887007129 Mg2+ binding site [ion binding]; other site 637887007130 G-X-G motif; other site 637887007131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887007132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007133 active site 637887007134 phosphorylation site [posttranslational modification] 637887007135 intermolecular recognition site; other site 637887007136 dimerization interface [polypeptide binding]; other site 637887007137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887007138 DNA binding site [nucleotide binding] 637887007139 Flavin Reductases; Region: FlaRed; cl00801 637887007140 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 637887007141 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 637887007142 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637887007143 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637887007144 Walker A/P-loop; other site 637887007145 ATP binding site [chemical binding]; other site 637887007146 Q-loop/lid; other site 637887007147 ABC transporter signature motif; other site 637887007148 Walker B; other site 637887007149 D-loop; other site 637887007150 H-loop/switch region; other site 637887007151 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 637887007152 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 637887007153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637887007154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637887007155 non-specific DNA binding site [nucleotide binding]; other site 637887007156 salt bridge; other site 637887007157 sequence-specific DNA binding site [nucleotide binding]; other site 637887007158 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 637887007159 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 637887007160 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637887007161 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 637887007162 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 637887007163 GatB domain; Region: GatB_Yqey; smart00845 637887007164 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 637887007165 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 637887007166 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 637887007167 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 637887007168 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 637887007169 dimer interface [polypeptide binding]; other site 637887007170 anticodon binding site; other site 637887007171 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 637887007172 homodimer interface [polypeptide binding]; other site 637887007173 motif 1; other site 637887007174 active site 637887007175 motif 2; other site 637887007176 GAD domain; Region: GAD; pfam02938 637887007177 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637887007178 active site 637887007179 motif 3; other site 637887007180 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 637887007181 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 637887007182 Uncharacterized conserved protein [Function unknown]; Region: COG2006 637887007183 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 637887007184 enoyl-CoA hydratase; Provisional; Region: PRK06688 637887007185 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637887007186 substrate binding site [chemical binding]; other site 637887007187 oxyanion hole (OAH) forming residues; other site 637887007188 trimer interface [polypeptide binding]; other site 637887007189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887007190 S-adenosylmethionine binding site [chemical binding]; other site 637887007191 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 637887007192 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 637887007193 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637887007194 DNA binding site [nucleotide binding] 637887007195 active site 637887007196 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 637887007197 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 637887007198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887007199 dimer interface [polypeptide binding]; other site 637887007200 ABC-ATPase subunit interface; other site 637887007201 putative PBP binding loops; other site 637887007202 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 637887007203 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637887007204 Walker A/P-loop; other site 637887007205 ATP binding site [chemical binding]; other site 637887007206 Q-loop/lid; other site 637887007207 ABC transporter signature motif; other site 637887007208 Walker B; other site 637887007209 D-loop; other site 637887007210 H-loop/switch region; other site 637887007211 Transcriptional regulator; Region: Rrf2; cl17282 637887007212 Rrf2 family protein; Region: rrf2_super; TIGR00738 637887007213 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 637887007214 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637887007215 homodimer interface [polypeptide binding]; other site 637887007216 substrate-cofactor binding pocket; other site 637887007217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887007218 catalytic residue [active] 637887007219 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637887007220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637887007221 dimer interface [polypeptide binding]; other site 637887007222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887007223 catalytic residue [active] 637887007224 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 637887007225 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 637887007226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637887007227 FtsX-like permease family; Region: FtsX; pfam02687 637887007228 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887007229 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887007230 Walker A/P-loop; other site 637887007231 ATP binding site [chemical binding]; other site 637887007232 Q-loop/lid; other site 637887007233 ABC transporter signature motif; other site 637887007234 Walker B; other site 637887007235 D-loop; other site 637887007236 H-loop/switch region; other site 637887007237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887007238 Coenzyme A binding pocket [chemical binding]; other site 637887007239 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 637887007240 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 637887007241 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 637887007242 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 637887007243 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 637887007244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887007245 Radical SAM superfamily; Region: Radical_SAM; pfam04055 637887007246 FeS/SAM binding site; other site 637887007247 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 637887007248 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637887007249 homodimer interface [polypeptide binding]; other site 637887007250 substrate-cofactor binding pocket; other site 637887007251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887007252 catalytic residue [active] 637887007253 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637887007254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887007255 substrate binding pocket [chemical binding]; other site 637887007256 membrane-bound complex binding site; other site 637887007257 hinge residues; other site 637887007258 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637887007259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887007260 dimer interface [polypeptide binding]; other site 637887007261 conserved gate region; other site 637887007262 putative PBP binding loops; other site 637887007263 ABC-ATPase subunit interface; other site 637887007264 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637887007265 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637887007266 Walker A/P-loop; other site 637887007267 ATP binding site [chemical binding]; other site 637887007268 Q-loop/lid; other site 637887007269 ABC transporter signature motif; other site 637887007270 Walker B; other site 637887007271 D-loop; other site 637887007272 H-loop/switch region; other site 637887007273 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 637887007274 nitrogenase iron protein; Region: nifH; TIGR01287 637887007275 Nucleotide-binding sites [chemical binding]; other site 637887007276 Walker A motif; other site 637887007277 Switch I region of nucleotide binding site; other site 637887007278 Fe4S4 binding sites [ion binding]; other site 637887007279 Switch II region of nucleotide binding site; other site 637887007280 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 637887007281 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 637887007282 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 637887007283 ligand binding site [chemical binding]; other site 637887007284 Protein of unknown function (DUF3029); Region: DUF3029; pfam11230 637887007285 Pyruvate formate lyase; Region: PFL; pfam02901 637887007286 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637887007287 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 637887007288 4Fe-4S binding domain; Region: Fer4; pfam00037 637887007289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887007290 FeS/SAM binding site; other site 637887007291 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 637887007292 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637887007293 Walker A/P-loop; other site 637887007294 ATP binding site [chemical binding]; other site 637887007295 Q-loop/lid; other site 637887007296 ABC transporter signature motif; other site 637887007297 Walker B; other site 637887007298 D-loop; other site 637887007299 H-loop/switch region; other site 637887007300 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637887007301 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637887007302 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637887007303 TM-ABC transporter signature motif; other site 637887007304 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637887007305 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637887007306 TM-ABC transporter signature motif; other site 637887007307 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637887007308 active site 637887007309 catalytic motif [active] 637887007310 Zn binding site [ion binding]; other site 637887007311 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637887007312 intersubunit interface [polypeptide binding]; other site 637887007313 active site 637887007314 catalytic residue [active] 637887007315 Response regulator receiver domain; Region: Response_reg; pfam00072 637887007316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007317 active site 637887007318 phosphorylation site [posttranslational modification] 637887007319 intermolecular recognition site; other site 637887007320 dimerization interface [polypeptide binding]; other site 637887007321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887007322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637887007323 Histidine kinase; Region: His_kinase; pfam06580 637887007324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887007325 ATP binding site [chemical binding]; other site 637887007326 Mg2+ binding site [ion binding]; other site 637887007327 G-X-G motif; other site 637887007328 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 637887007329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887007330 dimer interface [polypeptide binding]; other site 637887007331 conserved gate region; other site 637887007332 putative PBP binding loops; other site 637887007333 ABC-ATPase subunit interface; other site 637887007334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887007335 dimer interface [polypeptide binding]; other site 637887007336 conserved gate region; other site 637887007337 ABC-ATPase subunit interface; other site 637887007338 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637887007339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887007340 Walker A/P-loop; other site 637887007341 ATP binding site [chemical binding]; other site 637887007342 Q-loop/lid; other site 637887007343 ABC transporter signature motif; other site 637887007344 Walker B; other site 637887007345 D-loop; other site 637887007346 H-loop/switch region; other site 637887007347 TOBE domain; Region: TOBE_2; pfam08402 637887007348 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 637887007349 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 637887007350 Penicillinase repressor; Region: Pencillinase_R; pfam03965 637887007351 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 637887007352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 637887007353 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 637887007354 PglZ domain; Region: PglZ; pfam08665 637887007355 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637887007356 ATP binding site [chemical binding]; other site 637887007357 putative Mg++ binding site [ion binding]; other site 637887007358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637887007359 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 637887007360 nucleotide binding region [chemical binding]; other site 637887007361 ATP-binding site [chemical binding]; other site 637887007362 DNA methylase; Region: N6_N4_Mtase; cl17433 637887007363 Transposase; Region: HTH_Tnp_1; pfam01527 637887007364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887007365 HTH-like domain; Region: HTH_21; pfam13276 637887007366 Integrase core domain; Region: rve; pfam00665 637887007367 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887007368 Integrase core domain; Region: rve_3; pfam13683 637887007369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 637887007370 minor groove reading motif; other site 637887007371 helix-hairpin-helix signature motif; other site 637887007372 substrate binding pocket [chemical binding]; other site 637887007373 active site 637887007374 YDG/SRA domain; Region: YDG_SRA; cl02620 637887007375 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 637887007376 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637887007377 active site 637887007378 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 637887007379 active site 637887007380 8-oxo-dGMP binding site [chemical binding]; other site 637887007381 nudix motif; other site 637887007382 metal binding site [ion binding]; metal-binding site 637887007383 Helix-turn-helix domain; Region: HTH_38; pfam13936 637887007384 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 637887007385 Integrase core domain; Region: rve; pfam00665 637887007386 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637887007387 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637887007388 catalytic residues [active] 637887007389 catalytic nucleophile [active] 637887007390 Recombinase; Region: Recombinase; pfam07508 637887007391 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 637887007392 Recombinase; Region: Recombinase; pfam07508 637887007393 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637887007394 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637887007395 catalytic residues [active] 637887007396 catalytic nucleophile [active] 637887007397 Recombinase; Region: Recombinase; pfam07508 637887007398 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 637887007399 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 637887007400 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637887007401 amidase catalytic site [active] 637887007402 Zn binding residues [ion binding]; other site 637887007403 substrate binding site [chemical binding]; other site 637887007404 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887007405 Holin family; Region: Phage_holin_4; pfam05105 637887007406 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 637887007407 active site 637887007408 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 637887007409 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 637887007410 Phage-related protein [Function unknown]; Region: COG4722 637887007411 Phage tail protein; Region: Sipho_tail; pfam05709 637887007412 Phage-related minor tail protein [Function unknown]; Region: COG5280 637887007413 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 637887007414 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 637887007415 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 637887007416 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 637887007417 oligomerization interface [polypeptide binding]; other site 637887007418 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 637887007419 Phage capsid family; Region: Phage_capsid; pfam05065 637887007420 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 637887007421 oligomer interface [polypeptide binding]; other site 637887007422 active site residues [active] 637887007423 Phage-related protein [Function unknown]; Region: COG4695 637887007424 Phage portal protein; Region: Phage_portal; pfam04860 637887007425 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 637887007426 thioester formation/cholesterol transfer; other site 637887007427 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 637887007428 Phage Terminase; Region: Terminase_1; pfam03354 637887007429 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 637887007430 putative active site pocket [active] 637887007431 dimerization interface [polypeptide binding]; other site 637887007432 putative catalytic residue [active] 637887007433 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 637887007434 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 637887007435 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 637887007436 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 637887007437 ParB-like nuclease domain; Region: ParB; smart00470 637887007438 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637887007439 DNA methylase; Region: N6_N4_Mtase; cl17433 637887007440 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 637887007441 ParB-like nuclease domain; Region: ParB; smart00470 637887007442 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637887007443 DNA methylase; Region: N6_N4_Mtase; pfam01555 637887007444 Phage terminase, small subunit; Region: Terminase_4; cl01525 637887007445 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637887007446 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 637887007447 active site 637887007448 VRR-NUC domain; Region: VRR_NUC; pfam08774 637887007449 HTH domain; Region: HTH_11; pfam08279 637887007450 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887007451 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887007452 Walker A/P-loop; other site 637887007453 ATP binding site [chemical binding]; other site 637887007454 Q-loop/lid; other site 637887007455 ABC transporter signature motif; other site 637887007456 Walker B; other site 637887007457 D-loop; other site 637887007458 H-loop/switch region; other site 637887007459 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637887007460 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637887007461 FtsX-like permease family; Region: FtsX; pfam02687 637887007462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887007463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887007464 ATP binding site [chemical binding]; other site 637887007465 Mg2+ binding site [ion binding]; other site 637887007466 G-X-G motif; other site 637887007467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887007468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007469 active site 637887007470 phosphorylation site [posttranslational modification] 637887007471 intermolecular recognition site; other site 637887007472 dimerization interface [polypeptide binding]; other site 637887007473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887007474 DNA binding site [nucleotide binding] 637887007475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637887007476 TRAM domain; Region: TRAM; cl01282 637887007477 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 637887007478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887007479 S-adenosylmethionine binding site [chemical binding]; other site 637887007480 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637887007481 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637887007482 Walker A/P-loop; other site 637887007483 ATP binding site [chemical binding]; other site 637887007484 Q-loop/lid; other site 637887007485 ABC transporter signature motif; other site 637887007486 Walker B; other site 637887007487 D-loop; other site 637887007488 H-loop/switch region; other site 637887007489 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637887007490 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637887007491 ABC-ATPase subunit interface; other site 637887007492 dimer interface [polypeptide binding]; other site 637887007493 putative PBP binding regions; other site 637887007494 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637887007495 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 637887007496 putative binding site residues; other site 637887007497 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 637887007498 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 637887007499 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 637887007500 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 637887007501 Double zinc ribbon; Region: DZR; pfam12773 637887007502 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 637887007503 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 637887007504 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637887007505 Peptidase family M23; Region: Peptidase_M23; pfam01551 637887007506 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 637887007507 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 637887007508 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 637887007509 Transglycosylase; Region: Transgly; pfam00912 637887007510 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637887007511 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637887007512 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637887007513 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637887007514 FtsX-like permease family; Region: FtsX; pfam02687 637887007515 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 637887007516 HlyD family secretion protein; Region: HlyD_3; pfam13437 637887007517 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887007518 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887007519 Walker A/P-loop; other site 637887007520 ATP binding site [chemical binding]; other site 637887007521 Q-loop/lid; other site 637887007522 ABC transporter signature motif; other site 637887007523 Walker B; other site 637887007524 D-loop; other site 637887007525 H-loop/switch region; other site 637887007526 Outer membrane efflux protein; Region: OEP; pfam02321 637887007527 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 637887007528 gamma-glutamyl kinase; Provisional; Region: PRK05429 637887007529 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 637887007530 nucleotide binding site [chemical binding]; other site 637887007531 homotetrameric interface [polypeptide binding]; other site 637887007532 putative phosphate binding site [ion binding]; other site 637887007533 putative allosteric binding site; other site 637887007534 GGGtGRT protein; Region: GGGtGRT; pfam14057 637887007535 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 637887007536 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 637887007537 Rubrerythrin [Energy production and conversion]; Region: COG1592 637887007538 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 637887007539 binuclear metal center [ion binding]; other site 637887007540 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 637887007541 iron binding site [ion binding]; other site 637887007542 Uncharacterized conserved protein [Function unknown]; Region: COG1434 637887007543 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637887007544 putative active site [active] 637887007545 AAA domain; Region: AAA_32; pfam13654 637887007546 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 637887007547 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637887007548 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 637887007549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887007550 Coenzyme A binding pocket [chemical binding]; other site 637887007551 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 637887007552 Glycoprotease family; Region: Peptidase_M22; pfam00814 637887007553 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 637887007554 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 637887007555 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 637887007556 active site 637887007557 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007558 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007559 AAA domain; Region: AAA_17; pfam13207 637887007560 AAA domain; Region: AAA_18; pfam13238 637887007561 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 637887007562 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 637887007563 23S rRNA interface [nucleotide binding]; other site 637887007564 L3 interface [polypeptide binding]; other site 637887007565 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 637887007566 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 637887007567 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 637887007568 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 637887007569 DNA repair protein RadA; Provisional; Region: PRK11823 637887007570 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 637887007571 Walker A motif/ATP binding site; other site 637887007572 ATP binding site [chemical binding]; other site 637887007573 Walker B motif; other site 637887007574 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 637887007575 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 637887007576 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 637887007577 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 637887007578 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 637887007579 DXD motif; other site 637887007580 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 637887007581 Clp amino terminal domain; Region: Clp_N; pfam02861 637887007582 Clp amino terminal domain; Region: Clp_N; pfam02861 637887007583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887007584 Walker A motif; other site 637887007585 ATP binding site [chemical binding]; other site 637887007586 Walker B motif; other site 637887007587 arginine finger; other site 637887007588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887007589 Walker A motif; other site 637887007590 ATP binding site [chemical binding]; other site 637887007591 Walker B motif; other site 637887007592 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637887007593 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 637887007594 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 637887007595 ADP binding site [chemical binding]; other site 637887007596 phosphagen binding site; other site 637887007597 substrate specificity loop; other site 637887007598 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 637887007599 UvrB/uvrC motif; Region: UVR; pfam02151 637887007600 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 637887007601 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 637887007602 elongation factor G; Reviewed; Region: PRK12740 637887007603 G1 box; other site 637887007604 putative GEF interaction site [polypeptide binding]; other site 637887007605 GTP/Mg2+ binding site [chemical binding]; other site 637887007606 Switch I region; other site 637887007607 G2 box; other site 637887007608 G3 box; other site 637887007609 Switch II region; other site 637887007610 G4 box; other site 637887007611 G5 box; other site 637887007612 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 637887007613 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 637887007614 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 637887007615 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 637887007616 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 637887007617 prephenate dehydrogenase; Validated; Region: PRK08507 637887007618 prephenate dehydrogenase; Validated; Region: PRK06545 637887007619 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637887007620 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 637887007621 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 637887007622 hinge; other site 637887007623 active site 637887007624 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 637887007625 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 637887007626 CoA binding domain; Region: CoA_binding; smart00881 637887007627 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637887007628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887007629 Walker A/P-loop; other site 637887007630 ATP binding site [chemical binding]; other site 637887007631 Q-loop/lid; other site 637887007632 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637887007633 ABC transporter; Region: ABC_tran_2; pfam12848 637887007634 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637887007635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887007636 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 637887007637 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637887007638 Bacterial SH3 domain; Region: SH3_3; pfam08239 637887007639 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 637887007640 active site 637887007641 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637887007642 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637887007643 Walker A/P-loop; other site 637887007644 ATP binding site [chemical binding]; other site 637887007645 Q-loop/lid; other site 637887007646 ABC transporter signature motif; other site 637887007647 Walker B; other site 637887007648 D-loop; other site 637887007649 H-loop/switch region; other site 637887007650 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 637887007651 cobalt transport protein CbiM; Validated; Region: PRK06265 637887007652 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 637887007653 PDGLE domain; Region: PDGLE; pfam13190 637887007654 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 637887007655 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637887007656 active site 637887007657 metal binding site [ion binding]; metal-binding site 637887007658 Response regulator receiver domain; Region: Response_reg; pfam00072 637887007659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007660 active site 637887007661 phosphorylation site [posttranslational modification] 637887007662 intermolecular recognition site; other site 637887007663 dimerization interface [polypeptide binding]; other site 637887007664 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887007665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887007666 metal binding site [ion binding]; metal-binding site 637887007667 active site 637887007668 I-site; other site 637887007669 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 637887007670 anti-sigma E factor; Provisional; Region: rseB; PRK09455 637887007671 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 637887007672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887007673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637887007674 DNA binding residues [nucleotide binding] 637887007675 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 637887007676 Penicillinase repressor; Region: Pencillinase_R; pfam03965 637887007677 UreD urease accessory protein; Region: UreD; cl00530 637887007678 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 637887007679 G1 box; other site 637887007680 GTP/Mg2+ binding site [chemical binding]; other site 637887007681 G2 box; other site 637887007682 Switch I region; other site 637887007683 G3 box; other site 637887007684 Switch II region; other site 637887007685 G4 box; other site 637887007686 G5 box; other site 637887007687 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 637887007688 UreF; Region: UreF; pfam01730 637887007689 urease subunit alpha; Reviewed; Region: ureC; PRK13207 637887007690 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 637887007691 subunit interactions [polypeptide binding]; other site 637887007692 active site 637887007693 flap region; other site 637887007694 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 637887007695 gamma-beta subunit interface [polypeptide binding]; other site 637887007696 alpha-beta subunit interface [polypeptide binding]; other site 637887007697 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 637887007698 alpha-gamma subunit interface [polypeptide binding]; other site 637887007699 beta-gamma subunit interface [polypeptide binding]; other site 637887007700 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 637887007701 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 637887007702 Walker A/P-loop; other site 637887007703 ATP binding site [chemical binding]; other site 637887007704 Q-loop/lid; other site 637887007705 ABC transporter signature motif; other site 637887007706 Walker B; other site 637887007707 D-loop; other site 637887007708 H-loop/switch region; other site 637887007709 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 637887007710 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 637887007711 Walker A/P-loop; other site 637887007712 ATP binding site [chemical binding]; other site 637887007713 Q-loop/lid; other site 637887007714 ABC transporter signature motif; other site 637887007715 Walker B; other site 637887007716 D-loop; other site 637887007717 H-loop/switch region; other site 637887007718 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 637887007719 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 637887007720 TM-ABC transporter signature motif; other site 637887007721 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 637887007722 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637887007723 TM-ABC transporter signature motif; other site 637887007724 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 637887007725 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 637887007726 putative ligand binding site [chemical binding]; other site 637887007727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007728 Response regulator receiver domain; Region: Response_reg; pfam00072 637887007729 active site 637887007730 phosphorylation site [posttranslational modification] 637887007731 intermolecular recognition site; other site 637887007732 dimerization interface [polypeptide binding]; other site 637887007733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637887007734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887007735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887007736 dimer interface [polypeptide binding]; other site 637887007737 phosphorylation site [posttranslational modification] 637887007738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887007739 ATP binding site [chemical binding]; other site 637887007740 Mg2+ binding site [ion binding]; other site 637887007741 G-X-G motif; other site 637887007742 Response regulator receiver domain; Region: Response_reg; pfam00072 637887007743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007744 active site 637887007745 phosphorylation site [posttranslational modification] 637887007746 intermolecular recognition site; other site 637887007747 dimerization interface [polypeptide binding]; other site 637887007748 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637887007749 putative binding surface; other site 637887007750 active site 637887007751 Response regulator receiver domain; Region: Response_reg; pfam00072 637887007752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007753 active site 637887007754 phosphorylation site [posttranslational modification] 637887007755 intermolecular recognition site; other site 637887007756 dimerization interface [polypeptide binding]; other site 637887007757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887007758 ATP binding site [chemical binding]; other site 637887007759 Mg2+ binding site [ion binding]; other site 637887007760 G-X-G motif; other site 637887007761 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007762 TadE-like protein; Region: TadE; pfam07811 637887007763 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887007764 MULE transposase domain; Region: MULE; pfam10551 637887007765 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007766 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 637887007767 TadE-like protein; Region: TadE; pfam07811 637887007768 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637887007770 DDE superfamily endonuclease; Region: DDE_5; cl17874 637887007771 TadE-like protein; Region: TadE; pfam07811 637887007772 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007773 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887007774 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 637887007775 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887007776 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 637887007777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637887007778 FeS/SAM binding site; other site 637887007779 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 637887007780 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637887007781 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637887007782 dimer interface [polypeptide binding]; other site 637887007783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887007784 catalytic residue [active] 637887007785 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 637887007786 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 637887007787 Ligand Binding Site [chemical binding]; other site 637887007788 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 637887007789 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637887007790 homodimer interface [polypeptide binding]; other site 637887007791 substrate-cofactor binding pocket; other site 637887007792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887007793 catalytic residue [active] 637887007794 Predicted transcriptional regulator [Transcription]; Region: COG1959 637887007795 Transcriptional regulator; Region: Rrf2; cl17282 637887007796 Predicted transcriptional regulator [Transcription]; Region: COG1959 637887007797 Transcriptional regulator; Region: Rrf2; cl17282 637887007798 Homoserine O-succinyltransferase; Region: HTS; pfam04204 637887007799 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 637887007800 proposed active site lysine [active] 637887007801 conserved cys residue [active] 637887007802 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637887007803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887007804 dimerization interface [polypeptide binding]; other site 637887007805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887007806 dimer interface [polypeptide binding]; other site 637887007807 phosphorylation site [posttranslational modification] 637887007808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887007809 ATP binding site [chemical binding]; other site 637887007810 Mg2+ binding site [ion binding]; other site 637887007811 G-X-G motif; other site 637887007812 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887007813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887007814 active site 637887007815 phosphorylation site [posttranslational modification] 637887007816 intermolecular recognition site; other site 637887007817 dimerization interface [polypeptide binding]; other site 637887007818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887007819 DNA binding site [nucleotide binding] 637887007820 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637887007821 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637887007822 metal-binding site [ion binding] 637887007823 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637887007824 Soluble P-type ATPase [General function prediction only]; Region: COG4087 637887007825 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637887007826 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637887007827 metal-binding site [ion binding] 637887007828 Family description; Region: DsbD_2; pfam13386 637887007829 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 637887007830 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 637887007831 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 637887007832 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 637887007833 dimerization interface [polypeptide binding]; other site 637887007834 domain crossover interface; other site 637887007835 redox-dependent activation switch; other site 637887007836 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 637887007837 DNA-binding site [nucleotide binding]; DNA binding site 637887007838 RNA-binding motif; other site 637887007839 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637887007840 DNA binding site [nucleotide binding] 637887007841 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 637887007842 active site 637887007843 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637887007844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887007845 S-adenosylmethionine binding site [chemical binding]; other site 637887007846 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637887007847 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 637887007848 C-terminal peptidase (prc); Region: prc; TIGR00225 637887007849 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 637887007850 protein binding site [polypeptide binding]; other site 637887007851 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 637887007852 Catalytic dyad [active] 637887007853 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 637887007854 CHD5-like protein; Region: CHD5; pfam04420 637887007855 Peptidase family M23; Region: Peptidase_M23; pfam01551 637887007856 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 637887007857 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 637887007858 FtsX-like permease family; Region: FtsX; pfam02687 637887007859 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 637887007860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887007861 Walker A/P-loop; other site 637887007862 ATP binding site [chemical binding]; other site 637887007863 Q-loop/lid; other site 637887007864 ABC transporter signature motif; other site 637887007865 Walker B; other site 637887007866 D-loop; other site 637887007867 H-loop/switch region; other site 637887007868 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 637887007869 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 637887007870 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 637887007871 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637887007872 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637887007873 Walker A/P-loop; other site 637887007874 ATP binding site [chemical binding]; other site 637887007875 Q-loop/lid; other site 637887007876 ABC transporter signature motif; other site 637887007877 Walker B; other site 637887007878 D-loop; other site 637887007879 H-loop/switch region; other site 637887007880 TOBE domain; Region: TOBE; pfam03459 637887007881 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 637887007882 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637887007883 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 637887007884 feedback inhibition sensing region; other site 637887007885 homohexameric interface [polypeptide binding]; other site 637887007886 nucleotide binding site [chemical binding]; other site 637887007887 N-acetyl-L-glutamate binding site [chemical binding]; other site 637887007888 PilZ domain; Region: PilZ; pfam07238 637887007889 acetylornithine aminotransferase; Provisional; Region: PRK02627 637887007890 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637887007891 inhibitor-cofactor binding pocket; inhibition site 637887007892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887007893 catalytic residue [active] 637887007894 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 637887007895 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 637887007896 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 637887007897 catalytic site [active] 637887007898 subunit interface [polypeptide binding]; other site 637887007899 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 637887007900 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637887007901 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637887007902 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 637887007903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637887007904 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637887007905 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 637887007906 IMP binding site; other site 637887007907 dimer interface [polypeptide binding]; other site 637887007908 interdomain contacts; other site 637887007909 partial ornithine binding site; other site 637887007910 ornithine carbamoyltransferase; Provisional; Region: PRK00779 637887007911 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637887007912 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637887007913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637887007914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887007915 Coenzyme A binding pocket [chemical binding]; other site 637887007916 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 637887007917 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637887007918 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887007919 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887007920 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 637887007921 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 637887007922 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 637887007923 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 637887007924 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 637887007925 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637887007926 Predicted transcriptional regulators [Transcription]; Region: COG1695 637887007927 Transcriptional regulator PadR-like family; Region: PadR; cl17335 637887007928 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637887007929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637887007930 putative active site [active] 637887007931 putative metal binding site [ion binding]; other site 637887007932 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 637887007933 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 637887007934 Transposase, Mutator family; Region: Transposase_mut; pfam00872 637887007935 MULE transposase domain; Region: MULE; pfam10551 637887007936 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 637887007937 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 637887007938 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637887007939 catalytic residue [active] 637887007940 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 637887007941 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 637887007942 NodB motif; other site 637887007943 active site 637887007944 metal binding site [ion binding]; metal-binding site 637887007945 Condensation domain; Region: Condensation; pfam00668 637887007946 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 637887007947 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 637887007948 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 637887007949 acyl-activating enzyme (AAE) consensus motif; other site 637887007950 AMP binding site [chemical binding]; other site 637887007951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637887007952 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 637887007953 H+ Antiporter protein; Region: 2A0121; TIGR00900 637887007954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637887007955 putative substrate translocation pore; other site 637887007956 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 637887007957 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 637887007958 active site 637887007959 TDP-binding site; other site 637887007960 acceptor substrate-binding pocket; other site 637887007961 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 637887007962 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 637887007963 active site 637887007964 TDP-binding site; other site 637887007965 acceptor substrate-binding pocket; other site 637887007966 homodimer interface [polypeptide binding]; other site 637887007967 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 637887007968 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 637887007969 acyl-activating enzyme (AAE) consensus motif; other site 637887007970 AMP binding site [chemical binding]; other site 637887007971 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637887007972 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007973 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887007974 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007975 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887007976 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887007977 metal binding site [ion binding]; metal-binding site 637887007978 ligand binding site [chemical binding]; other site 637887007979 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887007980 S-layer homology domain; Region: SLH; pfam00395 637887007981 S-layer homology domain; Region: SLH; pfam00395 637887007982 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887007983 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887007984 Rhomboid family; Region: Rhomboid; cl11446 637887007985 Family description; Region: VCBS; pfam13517 637887007986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637887007987 binding surface 637887007988 TPR motif; other site 637887007989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887007990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887007991 dimerization interface [polypeptide binding]; other site 637887007992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887007993 dimer interface [polypeptide binding]; other site 637887007994 phosphorylation site [posttranslational modification] 637887007995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887007996 ATP binding site [chemical binding]; other site 637887007997 Mg2+ binding site [ion binding]; other site 637887007998 G-X-G motif; other site 637887007999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887008000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887008001 active site 637887008002 phosphorylation site [posttranslational modification] 637887008003 intermolecular recognition site; other site 637887008004 dimerization interface [polypeptide binding]; other site 637887008005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887008006 DNA binding site [nucleotide binding] 637887008007 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637887008008 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 637887008009 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637887008010 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637887008011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637887008012 motif II; other site 637887008013 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637887008014 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 637887008015 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 637887008016 homodimer interface [polypeptide binding]; other site 637887008017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887008018 catalytic residue [active] 637887008019 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637887008020 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 637887008021 MgtC family; Region: MgtC; pfam02308 637887008022 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637887008023 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 637887008024 Transcriptional regulator PadR-like family; Region: PadR; cl17335 637887008025 Predicted transcriptional regulators [Transcription]; Region: COG1695 637887008026 CTP synthetase; Validated; Region: pyrG; PRK05380 637887008027 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 637887008028 Catalytic site [active] 637887008029 active site 637887008030 UTP binding site [chemical binding]; other site 637887008031 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 637887008032 active site 637887008033 putative oxyanion hole; other site 637887008034 catalytic triad [active] 637887008035 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887008036 protein-splicing catalytic site; other site 637887008037 thioester formation/cholesterol transfer; other site 637887008038 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887008039 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 637887008040 C-terminal peptidase (prc); Region: prc; TIGR00225 637887008041 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 637887008042 protein binding site [polypeptide binding]; other site 637887008043 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 637887008044 Catalytic dyad [active] 637887008045 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 637887008046 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887008047 S-layer homology domain; Region: SLH; pfam00395 637887008048 S-layer homology domain; Region: SLH; pfam00395 637887008049 S-layer homology domain; Region: SLH; pfam00395 637887008050 S-layer homology domain; Region: SLH; pfam00395 637887008051 S-layer homology domain; Region: SLH; pfam00395 637887008052 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 637887008053 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 637887008054 CAAX protease self-immunity; Region: Abi; pfam02517 637887008055 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 637887008056 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 637887008057 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 637887008058 active site 637887008059 HIGH motif; other site 637887008060 KMSK motif region; other site 637887008061 tRNA binding surface [nucleotide binding]; other site 637887008062 DALR anticodon binding domain; Region: DALR_1; smart00836 637887008063 anticodon binding site; other site 637887008064 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 637887008065 glutamate racemase; Provisional; Region: PRK00865 637887008066 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 637887008067 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637887008068 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 637887008069 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 637887008070 MgtE intracellular N domain; Region: MgtE_N; smart00924 637887008071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 637887008072 Divalent cation transporter; Region: MgtE; pfam01769 637887008073 RDD family; Region: RDD; pfam06271 637887008074 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 637887008075 Sporulation and spore germination; Region: Germane; pfam10646 637887008076 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637887008077 intersubunit interface [polypeptide binding]; other site 637887008078 active site 637887008079 catalytic residue [active] 637887008080 Protein of unknown function (DUF458); Region: DUF458; pfam04308 637887008081 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 637887008082 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 637887008083 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637887008084 catalytic residues [active] 637887008085 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 637887008086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637887008087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637887008088 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 637887008089 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637887008090 catalytic residues [active] 637887008091 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 637887008092 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 637887008093 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 637887008094 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887008095 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637887008096 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 637887008097 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 637887008098 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 637887008099 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 637887008100 RNA binding site [nucleotide binding]; other site 637887008101 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637887008102 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637887008103 putative substrate binding site [chemical binding]; other site 637887008104 putative ATP binding site [chemical binding]; other site 637887008105 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637887008106 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 637887008107 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 637887008108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887008109 S-adenosylmethionine binding site [chemical binding]; other site 637887008110 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 637887008111 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887008112 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637887008113 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 637887008114 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 637887008115 active site 637887008116 Substrate binding site; other site 637887008117 Mg++ binding site; other site 637887008118 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637887008119 putative trimer interface [polypeptide binding]; other site 637887008120 putative CoA binding site [chemical binding]; other site 637887008121 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 637887008122 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 637887008123 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637887008124 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637887008125 active site 637887008126 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 637887008127 Putative esterase; Region: Esterase; pfam00756 637887008128 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887008129 metal binding site [ion binding]; metal-binding site 637887008130 ligand binding site [chemical binding]; other site 637887008131 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008132 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 637887008133 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 637887008134 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 637887008135 catalytic residue [active] 637887008136 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 637887008137 catalytic residues [active] 637887008138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637887008139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637887008140 peroxiredoxin; Region: AhpC; TIGR03137 637887008141 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 637887008142 dimer interface [polypeptide binding]; other site 637887008143 decamer (pentamer of dimers) interface [polypeptide binding]; other site 637887008144 catalytic triad [active] 637887008145 peroxidatic and resolving cysteines [active] 637887008146 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637887008147 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637887008148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887008149 Walker A/P-loop; other site 637887008150 ATP binding site [chemical binding]; other site 637887008151 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 637887008152 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637887008153 COG (conserved oligomeric Golgi) complex component, COG2; Region: COG2; pfam06148 637887008154 Uncharacterized conserved protein [Function unknown]; Region: COG5444 637887008155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887008156 binding surface 637887008157 TPR motif; other site 637887008158 TPR repeat; Region: TPR_11; pfam13414 637887008159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637887008160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637887008161 binding surface 637887008162 TPR motif; other site 637887008163 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 637887008164 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887008165 protein-splicing catalytic site; other site 637887008166 thioester formation/cholesterol transfer; other site 637887008167 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887008168 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637887008169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637887008170 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637887008171 Resolvase, N terminal domain; Region: Resolvase; smart00857 637887008172 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637887008173 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 637887008174 DNA-binding interface [nucleotide binding]; DNA binding site 637887008175 Transposase; Region: HTH_Tnp_1; pfam01527 637887008176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887008177 HTH-like domain; Region: HTH_21; pfam13276 637887008178 Integrase core domain; Region: rve; pfam00665 637887008179 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887008180 Integrase core domain; Region: rve_3; pfam13683 637887008181 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 637887008182 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637887008183 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887008184 protein-splicing catalytic site; other site 637887008185 thioester formation/cholesterol transfer; other site 637887008186 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887008187 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 637887008188 active site 637887008189 NTP binding site [chemical binding]; other site 637887008190 metal binding triad [ion binding]; metal-binding site 637887008191 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 637887008192 polymerase nucleotide-binding site; other site 637887008193 DNA-binding residues [nucleotide binding]; DNA binding site 637887008194 nucleotide binding site [chemical binding]; other site 637887008195 primase nucleotide-binding site [nucleotide binding]; other site 637887008196 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 637887008197 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887008198 protein-splicing catalytic site; other site 637887008199 thioester formation/cholesterol transfer; other site 637887008200 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887008201 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 637887008202 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 637887008203 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887008204 protein-splicing catalytic site; other site 637887008205 thioester formation/cholesterol transfer; other site 637887008206 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887008207 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887008208 protein-splicing catalytic site; other site 637887008209 thioester formation/cholesterol transfer; other site 637887008210 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887008211 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637887008212 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 637887008213 Catalytic domain of Protein Kinases; Region: PKc; cd00180 637887008214 active site 637887008215 ATP binding site [chemical binding]; other site 637887008216 substrate binding site [chemical binding]; other site 637887008217 activation loop (A-loop); other site 637887008218 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 637887008219 Amidohydrolase; Region: Amidohydro_2; pfam04909 637887008220 active site 637887008221 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008222 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 637887008223 Part of AAA domain; Region: AAA_19; pfam13245 637887008224 Family description; Region: UvrD_C_2; pfam13538 637887008225 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 637887008226 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 637887008227 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 637887008228 Transposase; Region: HTH_Tnp_1; pfam01527 637887008229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637887008230 HTH-like domain; Region: HTH_21; pfam13276 637887008231 Integrase core domain; Region: rve; pfam00665 637887008232 DDE domain; Region: DDE_Tnp_IS240; pfam13610 637887008233 Integrase core domain; Region: rve_3; pfam13683 637887008234 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 637887008235 protein-splicing catalytic site; other site 637887008236 thioester formation/cholesterol transfer; other site 637887008237 Pretoxin HINT domain; Region: PT-HINT; pfam07591 637887008238 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 637887008239 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 637887008240 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 637887008241 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 637887008242 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 637887008243 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 637887008244 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 637887008245 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 637887008246 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 637887008247 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 637887008248 putative ADP-ribose binding site [chemical binding]; other site 637887008249 putative active site [active] 637887008250 RNA polymerase factor sigma-70; Validated; Region: PRK08295 637887008251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887008252 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 637887008253 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 637887008254 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 637887008255 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637887008256 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 637887008257 dimerization interface [polypeptide binding]; other site 637887008258 active site 637887008259 metal binding site [ion binding]; metal-binding site 637887008260 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637887008261 Spore germination protein; Region: Spore_permease; cl17796 637887008262 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 637887008263 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 637887008264 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 637887008265 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637887008266 active site 637887008267 HIGH motif; other site 637887008268 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637887008269 KMSKS motif; other site 637887008270 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637887008271 tRNA binding surface [nucleotide binding]; other site 637887008272 anticodon binding site; other site 637887008273 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 637887008274 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 637887008275 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 637887008276 trimer interface [polypeptide binding]; other site 637887008277 active site 637887008278 substrate binding site [chemical binding]; other site 637887008279 CoA binding site [chemical binding]; other site 637887008280 Membrane protein of unknown function; Region: DUF360; pfam04020 637887008281 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 637887008282 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 637887008283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637887008284 minor groove reading motif; other site 637887008285 helix-hairpin-helix signature motif; other site 637887008286 substrate binding pocket [chemical binding]; other site 637887008287 active site 637887008288 Asp23 family; Region: Asp23; pfam03780 637887008289 YtxC-like family; Region: YtxC; pfam08812 637887008290 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637887008291 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 637887008292 metal binding site [ion binding]; metal-binding site 637887008293 dimer interface [polypeptide binding]; other site 637887008294 Uncharacterized conserved protein [Function unknown]; Region: COG2155 637887008295 hypothetical protein; Validated; Region: PRK00110 637887008296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887008297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887008298 dimer interface [polypeptide binding]; other site 637887008299 phosphorylation site [posttranslational modification] 637887008300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887008301 ATP binding site [chemical binding]; other site 637887008302 Mg2+ binding site [ion binding]; other site 637887008303 G-X-G motif; other site 637887008304 CoA binding domain; Region: CoA_binding_2; pfam13380 637887008305 Uncharacterized conserved protein [Function unknown]; Region: COG1739 637887008306 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 637887008307 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 637887008308 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637887008309 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637887008310 Catalytic site [active] 637887008311 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 637887008312 active site 637887008313 Ap6A binding site [chemical binding]; other site 637887008314 nudix motif; other site 637887008315 metal binding site [ion binding]; metal-binding site 637887008316 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 637887008317 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 637887008318 HflX GTPase family; Region: HflX; cd01878 637887008319 G1 box; other site 637887008320 GTP/Mg2+ binding site [chemical binding]; other site 637887008321 Switch I region; other site 637887008322 G2 box; other site 637887008323 G3 box; other site 637887008324 Switch II region; other site 637887008325 G4 box; other site 637887008326 G5 box; other site 637887008327 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 637887008328 DNA polymerase IV; Reviewed; Region: PRK03103 637887008329 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 637887008330 active site 637887008331 DNA binding site [nucleotide binding] 637887008332 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637887008333 trimer interface [polypeptide binding]; other site 637887008334 active site 637887008335 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637887008336 Peptidase family U32; Region: Peptidase_U32; pfam01136 637887008337 Collagenase; Region: DUF3656; pfam12392 637887008338 Peptidase family U32; Region: Peptidase_U32; pfam01136 637887008339 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 637887008340 Cell division protein ZapA; Region: ZapA; pfam05164 637887008341 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 637887008342 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008343 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008344 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 637887008345 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 637887008346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887008347 S-adenosylmethionine binding site [chemical binding]; other site 637887008348 Domain of unknown function (DUF348); Region: DUF348; pfam03990 637887008349 G5 domain; Region: G5; pfam07501 637887008350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 637887008351 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 637887008352 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 637887008353 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637887008354 active site 637887008355 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 637887008356 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 637887008357 active site 637887008358 HIGH motif; other site 637887008359 KMSKS motif; other site 637887008360 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 637887008361 tRNA binding surface [nucleotide binding]; other site 637887008362 anticodon binding site; other site 637887008363 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 637887008364 dimer interface [polypeptide binding]; other site 637887008365 putative tRNA-binding site [nucleotide binding]; other site 637887008366 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 637887008367 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 637887008368 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 637887008369 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 637887008370 Predicted methyltransferases [General function prediction only]; Region: COG0313 637887008371 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 637887008372 putative SAM binding site [chemical binding]; other site 637887008373 putative homodimer interface [polypeptide binding]; other site 637887008374 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 637887008375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887008376 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637887008377 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637887008378 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 637887008379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887008380 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 637887008381 Walker A motif; other site 637887008382 ATP binding site [chemical binding]; other site 637887008383 DNA polymerase III subunit delta'; Validated; Region: PRK07132 637887008384 Walker B motif; other site 637887008385 arginine finger; other site 637887008386 Protein of unknown function (DUF327); Region: DUF327; pfam03885 637887008387 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 637887008388 thymidylate kinase; Provisional; Region: PRK13975; cl17243 637887008389 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 637887008390 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 637887008391 homodimer interface [polypeptide binding]; other site 637887008392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887008393 catalytic residue [active] 637887008394 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637887008395 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887008396 Beta propeller domain; Region: Beta_propel; pfam09826 637887008397 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887008398 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887008399 Walker A/P-loop; other site 637887008400 ATP binding site [chemical binding]; other site 637887008401 Q-loop/lid; other site 637887008402 ABC transporter signature motif; other site 637887008403 Walker B; other site 637887008404 D-loop; other site 637887008405 H-loop/switch region; other site 637887008406 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637887008407 FtsX-like permease family; Region: FtsX; pfam02687 637887008408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887008409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887008410 active site 637887008411 phosphorylation site [posttranslational modification] 637887008412 intermolecular recognition site; other site 637887008413 dimerization interface [polypeptide binding]; other site 637887008414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887008415 DNA binding site [nucleotide binding] 637887008416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887008417 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 637887008418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887008419 ATP binding site [chemical binding]; other site 637887008420 Mg2+ binding site [ion binding]; other site 637887008421 G-X-G motif; other site 637887008422 Domain of unknown function DUF77; Region: DUF77; pfam01910 637887008423 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637887008424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887008425 dimer interface [polypeptide binding]; other site 637887008426 conserved gate region; other site 637887008427 putative PBP binding loops; other site 637887008428 ABC-ATPase subunit interface; other site 637887008429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 637887008430 NMT1/THI5 like; Region: NMT1; pfam09084 637887008431 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637887008432 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637887008433 Walker A/P-loop; other site 637887008434 ATP binding site [chemical binding]; other site 637887008435 Q-loop/lid; other site 637887008436 ABC transporter signature motif; other site 637887008437 Walker B; other site 637887008438 D-loop; other site 637887008439 H-loop/switch region; other site 637887008440 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637887008441 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 637887008442 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637887008443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637887008444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637887008445 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 637887008446 HlyD family secretion protein; Region: HlyD_3; pfam13437 637887008447 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637887008448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887008449 dimer interface [polypeptide binding]; other site 637887008450 conserved gate region; other site 637887008451 putative PBP binding loops; other site 637887008452 ABC-ATPase subunit interface; other site 637887008453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887008454 dimer interface [polypeptide binding]; other site 637887008455 conserved gate region; other site 637887008456 ABC-ATPase subunit interface; other site 637887008457 MoxR-like ATPases [General function prediction only]; Region: COG0714 637887008458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637887008459 Walker A motif; other site 637887008460 ATP binding site [chemical binding]; other site 637887008461 Walker B motif; other site 637887008462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637887008463 Uncharacterized conserved protein [Function unknown]; Region: COG3595 637887008464 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 637887008465 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 637887008466 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 637887008467 AAA domain; Region: AAA_21; pfam13304 637887008468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887008469 Walker B; other site 637887008470 D-loop; other site 637887008471 H-loop/switch region; other site 637887008472 RloB-like protein; Region: RloB; pfam13707 637887008473 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 637887008474 putative metal binding site [ion binding]; other site 637887008475 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 637887008476 Ca binding site [ion binding]; other site 637887008477 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008478 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 637887008479 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 637887008480 active site 637887008481 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008482 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008483 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 637887008484 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 637887008485 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 637887008486 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 637887008487 active site 637887008488 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008489 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008490 PhosphatidylEthanolamine-Binding Protein (PEBP) domain; Region: PEBP; cl00227 637887008491 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 637887008492 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887008493 Zn2+ binding site [ion binding]; other site 637887008494 Mg2+ binding site [ion binding]; other site 637887008495 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 637887008496 recombination protein RecR; Reviewed; Region: recR; PRK00076 637887008497 RecR protein; Region: RecR; pfam02132 637887008498 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 637887008499 putative active site [active] 637887008500 putative metal-binding site [ion binding]; other site 637887008501 tetramer interface [polypeptide binding]; other site 637887008502 hypothetical protein; Validated; Region: PRK00153 637887008503 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 637887008504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887008505 Walker A motif; other site 637887008506 ATP binding site [chemical binding]; other site 637887008507 Walker B motif; other site 637887008508 arginine finger; other site 637887008509 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 637887008510 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887008511 Cellulose binding domain; Region: CBM_3; smart01067 637887008512 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 637887008513 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887008514 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008515 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008516 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 637887008517 hypothetical protein; Provisional; Region: PRK07233 637887008518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637887008519 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637887008520 Predicted integral membrane protein [Function unknown]; Region: COG5542 637887008521 Predicted membrane protein [Function unknown]; Region: COG2246 637887008522 GtrA-like protein; Region: GtrA; pfam04138 637887008523 Methyltransferase domain; Region: Methyltransf_23; pfam13489 637887008524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887008525 S-adenosylmethionine binding site [chemical binding]; other site 637887008526 S-layer homology domain; Region: SLH; pfam00395 637887008527 S-layer homology domain; Region: SLH; pfam00395 637887008528 S-layer homology domain; Region: SLH; pfam00395 637887008529 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 637887008530 Lamin Tail Domain; Region: LTD; pfam00932 637887008531 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 637887008532 CotH protein; Region: CotH; pfam08757 637887008533 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 637887008534 Peptidase C26; Region: Peptidase_C26; pfam07722 637887008535 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 637887008536 catalytic triad [active] 637887008537 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 637887008538 anti sigma factor interaction site; other site 637887008539 regulatory phosphorylation site [posttranslational modification]; other site 637887008540 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 637887008541 Rubredoxin; Region: Rubredoxin; pfam00301 637887008542 iron binding site [ion binding]; other site 637887008543 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 637887008544 PAS domain; Region: PAS_9; pfam13426 637887008545 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 637887008546 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 637887008547 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 637887008548 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637887008549 phosphodiesterase YaeI; Provisional; Region: PRK11340 637887008550 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637887008551 putative active site [active] 637887008552 putative metal binding site [ion binding]; other site 637887008553 Putative amidase domain; Region: Amidase_6; pfam12671 637887008554 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 637887008555 putative Mg++ binding site [ion binding]; other site 637887008556 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 637887008557 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 637887008558 transcription termination factor Rho; Provisional; Region: PRK12608 637887008559 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 637887008560 RNA binding site [nucleotide binding]; other site 637887008561 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 637887008562 multimer interface [polypeptide binding]; other site 637887008563 Walker A motif; other site 637887008564 ATP binding site [chemical binding]; other site 637887008565 Walker B motif; other site 637887008566 CAAX protease self-immunity; Region: Abi; pfam02517 637887008567 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 637887008568 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637887008569 potential frameshift: common BLAST hit: gi|125974664|ref|YP_001038574.1| Pectate lyase/Amb allergen 637887008570 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 637887008571 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 637887008572 Amb_all domain; Region: Amb_all; smart00656 637887008573 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008574 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008575 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 637887008576 metal binding site [ion binding]; metal-binding site 637887008577 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637887008578 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 637887008579 Cl- selectivity filter; other site 637887008580 Cl- binding residues [ion binding]; other site 637887008581 pore gating glutamate residue; other site 637887008582 dimer interface [polypeptide binding]; other site 637887008583 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 637887008584 Ligand Binding Site [chemical binding]; other site 637887008585 TIGR00269 family protein; Region: TIGR00269 637887008586 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 637887008587 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637887008588 active site 637887008589 tetramer interface; other site 637887008590 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 637887008591 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 637887008592 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 637887008593 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637887008594 dimer interface [polypeptide binding]; other site 637887008595 ssDNA binding site [nucleotide binding]; other site 637887008596 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637887008597 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 637887008598 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 637887008599 GAF domain; Region: GAF_2; pfam13185 637887008600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637887008601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637887008602 metal binding site [ion binding]; metal-binding site 637887008603 active site 637887008604 I-site; other site 637887008605 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637887008606 Amidohydrolase; Region: Amidohydro_4; pfam13147 637887008607 active site 637887008608 dimer interface [polypeptide binding]; other site 637887008609 glycogen branching enzyme; Provisional; Region: PRK05402 637887008610 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 637887008611 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 637887008612 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 637887008613 active site 637887008614 catalytic site [active] 637887008615 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 637887008616 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 637887008617 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 637887008618 putative metal binding site [ion binding]; other site 637887008619 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 637887008620 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637887008621 Interdomain contacts; other site 637887008622 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008623 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008624 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 637887008625 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 637887008626 active site 637887008627 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887008628 metal binding site [ion binding]; metal-binding site 637887008629 ligand binding site [chemical binding]; other site 637887008630 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008631 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 637887008632 Putative esterase; Region: Esterase; pfam00756 637887008633 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887008634 metal binding site [ion binding]; metal-binding site 637887008635 ligand binding site [chemical binding]; other site 637887008636 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008637 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008638 Right handed beta helix region; Region: Beta_helix; pfam13229 637887008639 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887008640 metal binding site [ion binding]; metal-binding site 637887008641 ligand binding site [chemical binding]; other site 637887008642 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008643 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 637887008644 substrate binding site [chemical binding]; other site 637887008645 active site 637887008646 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887008647 metal binding site [ion binding]; metal-binding site 637887008648 ligand binding site [chemical binding]; other site 637887008649 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008650 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008651 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 637887008652 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 637887008653 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 637887008654 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 637887008655 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637887008656 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 637887008657 metal binding site [ion binding]; metal-binding site 637887008658 ligand binding site [chemical binding]; other site 637887008659 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008660 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887008662 Walker A/P-loop; other site 637887008663 ATP binding site [chemical binding]; other site 637887008664 AAA domain; Region: AAA_21; pfam13304 637887008665 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637887008666 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 637887008667 DNA binding residues [nucleotide binding] 637887008668 drug binding residues [chemical binding]; other site 637887008669 dimer interface [polypeptide binding]; other site 637887008670 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 637887008671 FtsX-like permease family; Region: FtsX; pfam02687 637887008672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637887008673 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637887008674 Walker A/P-loop; other site 637887008675 ATP binding site [chemical binding]; other site 637887008676 Q-loop/lid; other site 637887008677 ABC transporter signature motif; other site 637887008678 Walker B; other site 637887008679 D-loop; other site 637887008680 H-loop/switch region; other site 637887008681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637887008682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887008683 ATP binding site [chemical binding]; other site 637887008684 Mg2+ binding site [ion binding]; other site 637887008685 G-X-G motif; other site 637887008686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887008687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887008688 active site 637887008689 phosphorylation site [posttranslational modification] 637887008690 intermolecular recognition site; other site 637887008691 dimerization interface [polypeptide binding]; other site 637887008692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887008693 DNA binding site [nucleotide binding] 637887008694 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 637887008695 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637887008696 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 637887008697 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 637887008698 homodecamer interface [polypeptide binding]; other site 637887008699 GTP cyclohydrolase I; Provisional; Region: PLN03044 637887008700 active site 637887008701 putative catalytic site residues [active] 637887008702 zinc binding site [ion binding]; other site 637887008703 GTP-CH-I/GFRP interaction surface; other site 637887008704 cyanophycin synthetase; Provisional; Region: PRK14016 637887008705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637887008706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637887008707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637887008708 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 637887008709 proposed catalytic triad [active] 637887008710 active site nucleophile [active] 637887008711 isoaspartyl dipeptidase; Provisional; Region: PRK10657 637887008712 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637887008713 active site 637887008714 LexA repressor; Validated; Region: PRK00215 637887008715 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 637887008716 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637887008717 Catalytic site [active] 637887008718 tartrate dehydrogenase; Region: TTC; TIGR02089 637887008719 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 637887008720 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 637887008721 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 637887008722 substrate binding site [chemical binding]; other site 637887008723 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 637887008724 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 637887008725 substrate binding site [chemical binding]; other site 637887008726 ligand binding site [chemical binding]; other site 637887008727 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637887008728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887008729 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637887008730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887008731 hypothetical protein; Provisional; Region: PRK04164 637887008732 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 637887008733 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637887008734 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637887008735 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637887008736 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 637887008737 Cl binding site [ion binding]; other site 637887008738 oligomer interface [polypeptide binding]; other site 637887008739 FlgN protein; Region: FlgN; pfam05130 637887008740 Flagellar protein FliS; Region: FliS; cl00654 637887008741 flagellar capping protein; Validated; Region: fliD; PRK07737 637887008742 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 637887008743 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 637887008744 FlaG protein; Region: FlaG; pfam03646 637887008745 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637887008746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637887008747 NAD(P) binding site [chemical binding]; other site 637887008748 active site 637887008749 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 637887008750 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637887008751 inhibitor-cofactor binding pocket; inhibition site 637887008752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887008753 catalytic residue [active] 637887008754 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 637887008755 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637887008756 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 637887008757 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_1; cd08821 637887008758 putative active site [active] 637887008759 putative substrate binding site [chemical binding]; other site 637887008760 putative cosubstrate binding site; other site 637887008761 catalytic site [active] 637887008762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637887008763 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 637887008764 dimer interface [polypeptide binding]; other site 637887008765 substrate binding site [chemical binding]; other site 637887008766 metal binding site [ion binding]; metal-binding site 637887008767 FkbH-like domain; Region: FkbH; TIGR01686 637887008768 Acid Phosphatase; Region: Acid_PPase; cl17256 637887008769 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 637887008770 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 637887008771 pseudaminic acid synthase; Region: PseI; TIGR03586 637887008772 NeuB family; Region: NeuB; pfam03102 637887008773 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 637887008774 NeuB binding interface [polypeptide binding]; other site 637887008775 putative substrate binding site [chemical binding]; other site 637887008776 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 637887008777 ligand binding site; other site 637887008778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637887008779 S-adenosylmethionine binding site [chemical binding]; other site 637887008780 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 637887008781 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 637887008782 NAD(P) binding site [chemical binding]; other site 637887008783 homodimer interface [polypeptide binding]; other site 637887008784 substrate binding site [chemical binding]; other site 637887008785 active site 637887008786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 637887008787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 637887008788 flagellin; Provisional; Region: PRK12804 637887008789 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637887008790 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637887008791 flagellin; Provisional; Region: PRK12804 637887008792 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637887008793 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637887008794 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 637887008795 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 637887008796 NAD(P) binding site [chemical binding]; other site 637887008797 catalytic residues [active] 637887008798 carbon storage regulator; Provisional; Region: PRK01712 637887008799 flagellar assembly protein FliW; Provisional; Region: PRK13285 637887008800 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 637887008801 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637887008802 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637887008803 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 637887008804 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637887008805 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637887008806 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 637887008807 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637887008808 FlgN protein; Region: FlgN; pfam05130 637887008809 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 637887008810 flagellar operon protein TIGR03826; Region: YvyF 637887008811 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 637887008812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887008813 active site 637887008814 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 637887008815 generic binding surface II; other site 637887008816 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 637887008817 generic binding surface I; other site 637887008818 AAA domain; Region: AAA_30; pfam13604 637887008819 Family description; Region: UvrD_C_2; pfam13538 637887008820 S-adenosylmethionine synthetase; Validated; Region: PRK05250 637887008821 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 637887008822 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 637887008823 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 637887008824 Predicted thioesterase [General function prediction only]; Region: COG5496 637887008825 FtsH Extracellular; Region: FtsH_ext; pfam06480 637887008826 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 637887008827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887008828 Walker A motif; other site 637887008829 ATP binding site [chemical binding]; other site 637887008830 Walker B motif; other site 637887008831 arginine finger; other site 637887008832 Peptidase family M41; Region: Peptidase_M41; pfam01434 637887008833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637887008834 active site 637887008835 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 637887008836 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 637887008837 Ligand Binding Site [chemical binding]; other site 637887008838 TilS substrate C-terminal domain; Region: TilS_C; smart00977 637887008839 replicative DNA helicase; Region: DnaB; TIGR00665 637887008840 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637887008841 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637887008842 Walker A motif; other site 637887008843 ATP binding site [chemical binding]; other site 637887008844 Walker B motif; other site 637887008845 DNA binding loops [nucleotide binding] 637887008846 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 637887008847 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 637887008848 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 637887008849 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 637887008850 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 637887008851 DHH family; Region: DHH; pfam01368 637887008852 DHHA1 domain; Region: DHHA1; pfam02272 637887008853 MazG-like family; Region: MazG-like; pfam12643 637887008854 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 637887008855 Prephenate dehydratase; Region: PDT; pfam00800 637887008856 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 637887008857 putative L-Phe binding site [chemical binding]; other site 637887008858 V-type ATP synthase subunit I; Validated; Region: PRK05771 637887008859 V-type ATP synthase subunit K; Validated; Region: PRK06558 637887008860 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 637887008861 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 637887008862 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 637887008863 V-type ATP synthase subunit C; Provisional; Region: PRK01198 637887008864 V-type ATP synthase subunit F; Provisional; Region: PRK01395 637887008865 V-type ATP synthase subunit A; Provisional; Region: PRK04192 637887008866 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637887008867 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 637887008868 Walker A motif/ATP binding site; other site 637887008869 Walker B motif; other site 637887008870 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637887008871 V-type ATP synthase subunit B; Provisional; Region: PRK04196 637887008872 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637887008873 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 637887008874 Walker A motif homologous position; other site 637887008875 Walker B motif; other site 637887008876 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637887008877 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 637887008878 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637887008879 ATP-binding cassette protein, ChvD family; Region: ABC_ABC_ChvD; TIGR03719 637887008880 ABC transporter; Region: ABC_tran_2; pfam12848 637887008881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637887008882 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887008883 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 637887008884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 637887008885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 637887008886 FtsH Extracellular; Region: FtsH_ext; pfam06480 637887008887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637887008888 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637887008889 Walker A motif; other site 637887008890 ATP binding site [chemical binding]; other site 637887008891 Walker B motif; other site 637887008892 arginine finger; other site 637887008893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887008894 hinge residues; other site 637887008895 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637887008896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637887008897 substrate binding pocket [chemical binding]; other site 637887008898 membrane-bound complex binding site; other site 637887008899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 637887008900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637887008901 putative PBP binding loops; other site 637887008902 dimer interface [polypeptide binding]; other site 637887008903 ABC-ATPase subunit interface; other site 637887008904 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637887008905 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637887008906 Walker A/P-loop; other site 637887008907 ATP binding site [chemical binding]; other site 637887008908 Q-loop/lid; other site 637887008909 ABC transporter signature motif; other site 637887008910 Walker B; other site 637887008911 D-loop; other site 637887008912 H-loop/switch region; other site 637887008913 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 637887008914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887008915 active site 637887008916 phosphorylation site [posttranslational modification] 637887008917 intermolecular recognition site; other site 637887008918 dimerization interface [polypeptide binding]; other site 637887008919 CheB methylesterase; Region: CheB_methylest; pfam01339 637887008920 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 637887008921 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 637887008922 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 637887008923 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887008924 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637887008925 dimer interface [polypeptide binding]; other site 637887008926 putative CheW interface [polypeptide binding]; other site 637887008927 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887008928 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637887008929 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 637887008930 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637887008931 putative binding surface; other site 637887008932 active site 637887008933 P2 response regulator binding domain; Region: P2; pfam07194 637887008934 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637887008935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887008936 ATP binding site [chemical binding]; other site 637887008937 Mg2+ binding site [ion binding]; other site 637887008938 G-X-G motif; other site 637887008939 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637887008940 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 637887008941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637887008942 active site 637887008943 DNA binding site [nucleotide binding] 637887008944 Int/Topo IB signature motif; other site 637887008945 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637887008946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637887008947 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 637887008948 substrate binding site [chemical binding]; other site 637887008949 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 637887008950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637887008951 Walker A/P-loop; other site 637887008952 ATP binding site [chemical binding]; other site 637887008953 Q-loop/lid; other site 637887008954 ABC transporter signature motif; other site 637887008955 Walker B; other site 637887008956 D-loop; other site 637887008957 H-loop/switch region; other site 637887008958 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 637887008959 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 637887008960 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 637887008961 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 637887008962 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 637887008963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637887008964 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 637887008965 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 637887008966 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 637887008967 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 637887008968 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 637887008969 FAD binding site [chemical binding]; other site 637887008970 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 637887008971 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637887008972 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 637887008973 Hemerythrin; Region: Hemerythrin; cd12107 637887008974 Fe binding site [ion binding]; other site 637887008975 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 637887008976 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 637887008977 Predicted amidohydrolase [General function prediction only]; Region: COG0388 637887008978 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 637887008979 putative active site [active] 637887008980 catalytic triad [active] 637887008981 putative dimer interface [polypeptide binding]; other site 637887008982 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 637887008983 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 637887008984 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 637887008985 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 637887008986 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 637887008987 Uncharacterized conserved protein [Function unknown]; Region: COG1434 637887008988 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637887008989 putative active site [active] 637887008990 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 637887008991 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 637887008992 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 637887008993 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 637887008994 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637887008995 hinge; other site 637887008996 active site 637887008997 YycH protein; Region: YycI; cl02015 637887008998 YycH protein; Region: YycI; pfam09648 637887008999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 637887009000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637887009001 dimerization interface [polypeptide binding]; other site 637887009002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637887009003 putative active site [active] 637887009004 heme pocket [chemical binding]; other site 637887009005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637887009006 dimer interface [polypeptide binding]; other site 637887009007 phosphorylation site [posttranslational modification] 637887009008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637887009009 ATP binding site [chemical binding]; other site 637887009010 Mg2+ binding site [ion binding]; other site 637887009011 G-X-G motif; other site 637887009012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637887009013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637887009014 active site 637887009015 phosphorylation site [posttranslational modification] 637887009016 intermolecular recognition site; other site 637887009017 dimerization interface [polypeptide binding]; other site 637887009018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637887009019 DNA binding site [nucleotide binding] 637887009020 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 637887009021 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 637887009022 NAD(P) binding site [chemical binding]; other site 637887009023 homodimer interface [polypeptide binding]; other site 637887009024 substrate binding site [chemical binding]; other site 637887009025 active site 637887009026 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 637887009027 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637887009028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887009029 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637887009030 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887009031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637887009032 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637887009033 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 637887009034 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637887009035 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 637887009036 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 637887009037 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 637887009038 DXD motif; other site 637887009039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 637887009040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637887009041 Coenzyme A binding pocket [chemical binding]; other site 637887009042 Bacterial sugar transferase; Region: Bac_transf; pfam02397 637887009043 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 637887009044 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637887009045 inhibitor-cofactor binding pocket; inhibition site 637887009046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637887009047 catalytic residue [active] 637887009048 O-Antigen ligase; Region: Wzy_C; cl04850 637887009049 O-Antigen ligase; Region: Wzy_C; pfam04932 637887009050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637887009051 TPR motif; other site 637887009052 TPR repeat; Region: TPR_11; pfam13414 637887009053 binding surface 637887009054 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 637887009055 Chain length determinant protein; Region: Wzz; cl15801 637887009056 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 637887009057 Bacterial Ig-like domain; Region: Big_5; pfam13205 637887009058 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637887009059 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637887009060 FOG: CBS domain [General function prediction only]; Region: COG0517 637887009061 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 637887009062 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637887009063 PGAP1-like protein; Region: PGAP1; pfam07819 637887009064 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 637887009065 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 637887009066 dimerization interface [polypeptide binding]; other site 637887009067 active site 637887009068 L-aspartate oxidase; Provisional; Region: PRK06175 637887009069 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 637887009070 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 637887009071 Quinolinate synthetase A protein; Region: NadA; pfam02445 637887009072 Accessory gene regulator B; Region: AgrB; pfam04647 637887009073 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637887009074 Zn2+ binding site [ion binding]; other site 637887009075 Mg2+ binding site [ion binding]; other site 637887009076 endoglucanase; Region: PLN02420 637887009077 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 637887009078 Cellulose binding domain; Region: CBM_3; cl03026 637887009079 Cellulose binding domain; Region: CBM_3; pfam00942 637887009080 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887009081 Dockerin type I repeat; Region: Dockerin_1; pfam00404 637887009082 DNA gyrase subunit A; Validated; Region: PRK05560 637887009083 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 637887009084 CAP-like domain; other site 637887009085 active site 637887009086 primary dimer interface [polypeptide binding]; other site 637887009087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637887009088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637887009089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637887009090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637887009091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637887009092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637887009093 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 637887009094 ParB-like nuclease domain; Region: ParBc; pfam02195 637887009095 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 637887009096 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 637887009097 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 637887009098 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 637887009099 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 637887009100 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 637887009101 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 637887009102 trmE is a tRNA modification GTPase; Region: trmE; cd04164 637887009103 G1 box; other site 637887009104 GTP/Mg2+ binding site [chemical binding]; other site 637887009105 Switch I region; other site 637887009106 G2 box; other site 637887009107 Switch II region; other site 637887009108 G3 box; other site 637887009109 G4 box; other site 637887009110 G5 box; other site 637887009111 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 637887009112 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 637887009113 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 637887009114 G-X-X-G motif; other site 637887009115 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 637887009116 RxxxH motif; other site 637887009117 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 637887009118 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 637887009119 Haemolytic domain; Region: Haemolytic; pfam01809 637887009120 ribonuclease P; Reviewed; Region: rnpA; PRK00499 637887009121 Ribosomal protein L34; Region: Ribosomal_L34; cl00370