-- dump date 20140619_050021 -- class Genbank::misc_feature -- table misc_feature_note -- id note 469383000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 469383000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 469383000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383000004 Walker A motif; other site 469383000005 ATP binding site [chemical binding]; other site 469383000006 Walker B motif; other site 469383000007 arginine finger; other site 469383000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 469383000009 DnaA box-binding interface [nucleotide binding]; other site 469383000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 469383000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 469383000012 putative DNA binding surface [nucleotide binding]; other site 469383000013 dimer interface [polypeptide binding]; other site 469383000014 beta-clamp/clamp loader binding surface; other site 469383000015 beta-clamp/translesion DNA polymerase binding surface; other site 469383000016 recombination protein F; Reviewed; Region: recF; PRK00064 469383000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383000018 Walker A/P-loop; other site 469383000019 ATP binding site [chemical binding]; other site 469383000020 Q-loop/lid; other site 469383000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383000022 ABC transporter signature motif; other site 469383000023 Walker B; other site 469383000024 D-loop; other site 469383000025 H-loop/switch region; other site 469383000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 469383000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 469383000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383000029 Mg2+ binding site [ion binding]; other site 469383000030 G-X-G motif; other site 469383000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 469383000032 anchoring element; other site 469383000033 dimer interface [polypeptide binding]; other site 469383000034 ATP binding site [chemical binding]; other site 469383000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 469383000036 active site 469383000037 putative metal-binding site [ion binding]; other site 469383000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 469383000039 DNA gyrase subunit A; Validated; Region: PRK05560 469383000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 469383000041 CAP-like domain; other site 469383000042 active site 469383000043 primary dimer interface [polypeptide binding]; other site 469383000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469383000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469383000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469383000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469383000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469383000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 469383000050 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 469383000051 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 469383000052 active site 469383000053 prephenate dehydratase; Provisional; Region: PRK11898 469383000054 Prephenate dehydratase; Region: PDT; pfam00800 469383000055 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 469383000056 putative L-Phe binding site [chemical binding]; other site 469383000057 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 469383000058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 469383000059 active site 469383000060 ATP binding site [chemical binding]; other site 469383000061 substrate binding site [chemical binding]; other site 469383000062 activation loop (A-loop); other site 469383000063 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 469383000064 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469383000065 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469383000066 phosphopeptide binding site; other site 469383000067 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469383000068 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469383000069 phosphopeptide binding site; other site 469383000070 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 469383000071 active site 469383000072 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 469383000073 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 469383000074 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469383000075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469383000076 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 469383000077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 469383000078 active site 469383000079 ATP binding site [chemical binding]; other site 469383000080 substrate binding site [chemical binding]; other site 469383000081 activation loop (A-loop); other site 469383000082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 469383000083 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469383000084 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469383000085 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469383000086 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469383000087 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 469383000088 Catalytic domain of Protein Kinases; Region: PKc; cd00180 469383000089 active site 469383000090 ATP binding site [chemical binding]; other site 469383000091 substrate binding site [chemical binding]; other site 469383000092 activation loop (A-loop); other site 469383000093 Global regulator protein family; Region: CsrA; pfam02599 469383000094 FliW protein; Region: FliW; cl00740 469383000095 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 469383000096 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 469383000097 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 469383000098 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 469383000099 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 469383000100 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 469383000101 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 469383000102 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 469383000103 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 469383000104 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 469383000105 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 469383000106 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 469383000107 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 469383000108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383000109 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383000110 DNA binding residues [nucleotide binding] 469383000111 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 469383000112 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 469383000113 putative metal binding site; other site 469383000114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 469383000115 TPR motif; other site 469383000116 binding surface 469383000117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 469383000118 binding surface 469383000119 FlaG protein; Region: FlaG; cl00591 469383000120 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 469383000121 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 469383000122 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 469383000123 Flagellar protein FliS; Region: FliS; cl00654 469383000124 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 469383000125 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 469383000126 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 469383000127 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 469383000128 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 469383000129 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 469383000130 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 469383000131 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 469383000132 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 469383000133 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 469383000134 FliG C-terminal domain; Region: FliG_C; pfam01706 469383000135 Flagellar assembly protein FliH; Region: FliH; pfam02108 469383000136 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 469383000137 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 469383000138 Walker A motif/ATP binding site; other site 469383000139 Walker B motif; other site 469383000140 short chain dehydrogenase; Provisional; Region: PRK08303 469383000141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000142 NAD(P) binding site [chemical binding]; other site 469383000143 active site 469383000144 HTH domain; Region: HTH_11; pfam08279 469383000145 WYL domain; Region: WYL; pfam13280 469383000146 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 469383000147 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 469383000148 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 469383000149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 469383000150 catalytic residue [active] 469383000151 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 469383000152 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 469383000153 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 469383000154 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 469383000155 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 469383000156 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 469383000157 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 469383000158 Flagellar protein (FlbD); Region: FlbD; cl00683 469383000159 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 469383000160 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 469383000161 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 469383000162 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 469383000163 ligand binding site [chemical binding]; other site 469383000164 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 469383000165 flagellar motor switch protein FliN; Region: fliN; TIGR02480 469383000166 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 469383000167 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 469383000168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000169 active site 469383000170 phosphorylation site [posttranslational modification] 469383000171 intermolecular recognition site; other site 469383000172 dimerization interface [polypeptide binding]; other site 469383000173 CheB methylesterase; Region: CheB_methylest; pfam01339 469383000174 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 469383000175 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 469383000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383000177 S-adenosylmethionine binding site [chemical binding]; other site 469383000178 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 469383000179 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 469383000180 putative binding surface; other site 469383000181 active site 469383000182 P2 response regulator binding domain; Region: P2; pfam07194 469383000183 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 469383000184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383000185 ATP binding site [chemical binding]; other site 469383000186 Mg2+ binding site [ion binding]; other site 469383000187 G-X-G motif; other site 469383000188 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 469383000189 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 469383000190 CheC-like family; Region: CheC; pfam04509 469383000191 CheC-like family; Region: CheC; pfam04509 469383000192 CheD chemotactic sensory transduction; Region: CheD; cl00810 469383000193 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 469383000194 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 469383000195 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 469383000196 Response regulator receiver domain; Region: Response_reg; pfam00072 469383000197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000198 active site 469383000199 phosphorylation site [posttranslational modification] 469383000200 intermolecular recognition site; other site 469383000201 dimerization interface [polypeptide binding]; other site 469383000202 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 469383000203 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 469383000204 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 469383000205 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 469383000206 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 469383000207 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 469383000208 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 469383000209 FHIPEP family; Region: FHIPEP; pfam00771 469383000210 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 469383000211 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 469383000212 PilZ domain; Region: PilZ; pfam07238 469383000213 flagellin; Provisional; Region: PRK12804 469383000214 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 469383000215 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 469383000216 flagellin; Provisional; Region: PRK12804 469383000217 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 469383000218 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 469383000219 flagellin; Provisional; Region: PRK12804 469383000220 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 469383000221 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 469383000222 flagellin; Provisional; Region: PRK12804 469383000223 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 469383000224 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 469383000225 CHAP domain; Region: CHAP; cl17642 469383000226 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383000227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 469383000228 active site 469383000229 phosphorylation site [posttranslational modification] 469383000230 intermolecular recognition site; other site 469383000231 dimerization interface [polypeptide binding]; other site 469383000232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383000233 dimerization interface [polypeptide binding]; other site 469383000234 DNA binding residues [nucleotide binding] 469383000235 Bacitracin resistance protein BacA; Region: BacA; pfam02673 469383000236 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 469383000237 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 469383000238 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383000239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469383000240 active site 469383000241 catalytic tetrad [active] 469383000242 Protein of unknown function (DUF354); Region: DUF354; pfam04007 469383000243 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 469383000244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383000245 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 469383000246 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 469383000247 NAD(P) binding site [chemical binding]; other site 469383000248 homodimer interface [polypeptide binding]; other site 469383000249 substrate binding site [chemical binding]; other site 469383000250 active site 469383000251 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 469383000252 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 469383000253 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 469383000254 hypothetical protein; Validated; Region: PRK00228 469383000255 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 469383000256 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 469383000257 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 469383000258 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 469383000259 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 469383000260 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 469383000261 Probable Catalytic site; other site 469383000262 metal-binding site 469383000263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383000264 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383000265 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 469383000266 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 469383000267 DXD motif; other site 469383000268 Bacterial sugar transferase; Region: Bac_transf; pfam02397 469383000269 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 469383000270 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 469383000271 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 469383000272 amidase catalytic site [active] 469383000273 Zn binding residues [ion binding]; other site 469383000274 substrate binding site [chemical binding]; other site 469383000275 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383000276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383000277 hypothetical protein; Provisional; Region: PRK08317 469383000278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383000279 S-adenosylmethionine binding site [chemical binding]; other site 469383000280 haloalkane dehalogenase; Provisional; Region: PRK00870 469383000281 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 469383000282 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 469383000283 TPP-binding site [chemical binding]; other site 469383000284 dimer interface [polypeptide binding]; other site 469383000285 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 469383000286 PYR/PP interface [polypeptide binding]; other site 469383000287 dimer interface [polypeptide binding]; other site 469383000288 TPP binding site [chemical binding]; other site 469383000289 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383000290 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 469383000291 TIR domain; Region: TIR_2; pfam13676 469383000292 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 469383000293 N-acetyl-D-glucosamine binding site [chemical binding]; other site 469383000294 catalytic residue [active] 469383000295 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383000296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383000297 non-specific DNA binding site [nucleotide binding]; other site 469383000298 salt bridge; other site 469383000299 sequence-specific DNA binding site [nucleotide binding]; other site 469383000300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383000301 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 469383000302 DNA methylase; Region: N6_N4_Mtase; pfam01555 469383000303 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383000304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383000305 DNA-binding site [nucleotide binding]; DNA binding site 469383000306 FCD domain; Region: FCD; pfam07729 469383000307 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383000308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000309 NAD(P) binding site [chemical binding]; other site 469383000310 active site 469383000311 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383000312 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383000313 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383000314 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383000315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000316 dimer interface [polypeptide binding]; other site 469383000317 conserved gate region; other site 469383000318 putative PBP binding loops; other site 469383000319 ABC-ATPase subunit interface; other site 469383000320 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383000321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000322 dimer interface [polypeptide binding]; other site 469383000323 conserved gate region; other site 469383000324 putative PBP binding loops; other site 469383000325 ABC-ATPase subunit interface; other site 469383000326 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383000327 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383000328 Walker A/P-loop; other site 469383000329 ATP binding site [chemical binding]; other site 469383000330 Q-loop/lid; other site 469383000331 ABC transporter signature motif; other site 469383000332 Walker B; other site 469383000333 D-loop; other site 469383000334 H-loop/switch region; other site 469383000335 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383000336 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383000337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383000338 Walker A/P-loop; other site 469383000339 ATP binding site [chemical binding]; other site 469383000340 Q-loop/lid; other site 469383000341 ABC transporter signature motif; other site 469383000342 Walker B; other site 469383000343 D-loop; other site 469383000344 H-loop/switch region; other site 469383000345 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383000346 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 469383000347 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 469383000348 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 469383000349 ligand binding site [chemical binding]; other site 469383000350 NAD binding site [chemical binding]; other site 469383000351 catalytic site [active] 469383000352 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383000353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000354 NAD(P) binding site [chemical binding]; other site 469383000355 active site 469383000356 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383000357 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383000358 metal binding site [ion binding]; metal-binding site 469383000359 substrate binding pocket [chemical binding]; other site 469383000360 acetoin reductases; Region: 23BDH; TIGR02415 469383000361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000362 NAD(P) binding site [chemical binding]; other site 469383000363 active site 469383000364 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 469383000365 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 469383000366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000367 NAD(P) binding site [chemical binding]; other site 469383000368 active site 469383000369 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 469383000370 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 469383000371 histidinol dehydrogenase; Region: hisD; TIGR00069 469383000372 NAD binding site [chemical binding]; other site 469383000373 dimerization interface [polypeptide binding]; other site 469383000374 product binding site; other site 469383000375 substrate binding site [chemical binding]; other site 469383000376 zinc binding site [ion binding]; other site 469383000377 catalytic residues [active] 469383000378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383000379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383000380 DNA binding site [nucleotide binding] 469383000381 domain linker motif; other site 469383000382 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383000383 dimerization interface [polypeptide binding]; other site 469383000384 ligand binding site [chemical binding]; other site 469383000385 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383000386 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383000387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383000388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000389 dimer interface [polypeptide binding]; other site 469383000390 conserved gate region; other site 469383000391 putative PBP binding loops; other site 469383000392 ABC-ATPase subunit interface; other site 469383000393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383000394 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 469383000395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000396 dimer interface [polypeptide binding]; other site 469383000397 conserved gate region; other site 469383000398 putative PBP binding loops; other site 469383000399 ABC-ATPase subunit interface; other site 469383000400 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383000401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383000402 Walker A/P-loop; other site 469383000403 ATP binding site [chemical binding]; other site 469383000404 Q-loop/lid; other site 469383000405 ABC transporter signature motif; other site 469383000406 Walker B; other site 469383000407 D-loop; other site 469383000408 H-loop/switch region; other site 469383000409 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383000410 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 469383000411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383000412 Walker A/P-loop; other site 469383000413 ATP binding site [chemical binding]; other site 469383000414 Q-loop/lid; other site 469383000415 ABC transporter signature motif; other site 469383000416 Walker B; other site 469383000417 D-loop; other site 469383000418 H-loop/switch region; other site 469383000419 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383000420 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 469383000421 Methyltransferase domain; Region: Methyltransf_18; pfam12847 469383000422 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383000423 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 469383000424 putative active site [active] 469383000425 putative metal binding site [ion binding]; other site 469383000426 PAS domain S-box; Region: sensory_box; TIGR00229 469383000427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383000428 putative active site [active] 469383000429 heme pocket [chemical binding]; other site 469383000430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383000431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383000432 metal binding site [ion binding]; metal-binding site 469383000433 active site 469383000434 I-site; other site 469383000435 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383000436 Predicted membrane protein [Function unknown]; Region: COG4270 469383000437 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 469383000438 hypothetical protein; Provisional; Region: PRK09256 469383000439 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 469383000440 BioY family; Region: BioY; pfam02632 469383000441 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 469383000442 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469383000443 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469383000444 phosphopeptide binding site; other site 469383000445 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 469383000446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383000447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383000448 DNA binding residues [nucleotide binding] 469383000449 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 469383000450 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 469383000451 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 469383000452 putative NADH binding site [chemical binding]; other site 469383000453 putative active site [active] 469383000454 nudix motif; other site 469383000455 putative metal binding site [ion binding]; other site 469383000456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383000457 Protein of unknown function (DUF664); Region: DUF664; pfam04978 469383000458 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383000459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000460 putative substrate translocation pore; other site 469383000461 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 469383000462 active site 469383000463 catalytic triad [active] 469383000464 oxyanion hole [active] 469383000465 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 469383000466 dimer interface [polypeptide binding]; other site 469383000467 active site 469383000468 ADP-ribose binding site [chemical binding]; other site 469383000469 nudix motif; other site 469383000470 metal binding site [ion binding]; metal-binding site 469383000471 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 469383000472 putative active site pocket [active] 469383000473 dimerization interface [polypeptide binding]; other site 469383000474 putative catalytic residue [active] 469383000475 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 469383000476 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 469383000477 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 469383000478 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 469383000479 DXD motif; other site 469383000480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 469383000481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383000482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000483 active site 469383000484 phosphorylation site [posttranslational modification] 469383000485 intermolecular recognition site; other site 469383000486 dimerization interface [polypeptide binding]; other site 469383000487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383000488 DNA binding residues [nucleotide binding] 469383000489 dimerization interface [polypeptide binding]; other site 469383000490 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 469383000491 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 469383000492 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383000493 dimer interface [polypeptide binding]; other site 469383000494 active site 469383000495 metal binding site [ion binding]; metal-binding site 469383000496 glutathione binding site [chemical binding]; other site 469383000497 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 469383000498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 469383000499 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 469383000500 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383000501 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383000502 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 469383000503 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383000504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383000505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000506 dimer interface [polypeptide binding]; other site 469383000507 conserved gate region; other site 469383000508 putative PBP binding loops; other site 469383000509 ABC-ATPase subunit interface; other site 469383000510 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383000511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000512 dimer interface [polypeptide binding]; other site 469383000513 conserved gate region; other site 469383000514 putative PBP binding loops; other site 469383000515 ABC-ATPase subunit interface; other site 469383000516 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 469383000517 active site 469383000518 substrate binding pocket [chemical binding]; other site 469383000519 homodimer interaction site [polypeptide binding]; other site 469383000520 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383000521 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383000522 catalytic residue [active] 469383000523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000524 NAD(P) binding site [chemical binding]; other site 469383000525 active site 469383000526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000527 active site 469383000528 dihydroorotase; Provisional; Region: PRK09237 469383000529 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383000530 active site 469383000531 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383000532 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383000533 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383000534 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 469383000535 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 469383000536 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383000537 catalytic residue [active] 469383000538 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383000539 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383000540 Walker A/P-loop; other site 469383000541 ATP binding site [chemical binding]; other site 469383000542 Q-loop/lid; other site 469383000543 ABC transporter signature motif; other site 469383000544 Walker B; other site 469383000545 D-loop; other site 469383000546 H-loop/switch region; other site 469383000547 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 469383000548 putative active site [active] 469383000549 homotetrameric interface [polypeptide binding]; other site 469383000550 metal binding site [ion binding]; metal-binding site 469383000551 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 469383000552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000553 putative substrate translocation pore; other site 469383000554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000555 Predicted acyl esterases [General function prediction only]; Region: COG2936 469383000556 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383000557 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383000558 PAS domain; Region: PAS_9; pfam13426 469383000559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383000560 PAS domain; Region: PAS_9; pfam13426 469383000561 putative active site [active] 469383000562 heme pocket [chemical binding]; other site 469383000563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383000564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383000565 metal binding site [ion binding]; metal-binding site 469383000566 active site 469383000567 I-site; other site 469383000568 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383000569 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 469383000570 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 469383000571 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 469383000572 homodimer interface [polypeptide binding]; other site 469383000573 substrate-cofactor binding pocket; other site 469383000574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383000575 catalytic residue [active] 469383000576 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 469383000577 active site 469383000578 homodimer interface [polypeptide binding]; other site 469383000579 TIR domain; Region: TIR_2; pfam13676 469383000580 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 469383000581 active site 469383000582 homodimer interface [polypeptide binding]; other site 469383000583 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 469383000584 putative deacylase active site [active] 469383000585 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 469383000586 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 469383000587 active site 469383000588 homotetramer interface [polypeptide binding]; other site 469383000589 homodimer interface [polypeptide binding]; other site 469383000590 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 469383000591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383000592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383000593 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 469383000594 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383000595 dimer interface [polypeptide binding]; other site 469383000596 active site 469383000597 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 469383000598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000599 NAD(P) binding site [chemical binding]; other site 469383000600 active site 469383000601 enoyl-CoA hydratase; Region: PLN02864 469383000602 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 469383000603 active site 2 [active] 469383000604 active site 1 [active] 469383000605 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 469383000606 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383000607 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 469383000608 active site 469383000609 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383000610 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383000611 active site 469383000612 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 469383000613 active site pocket [active] 469383000614 oxyanion hole [active] 469383000615 catalytic triad [active] 469383000616 active site nucleophile [active] 469383000617 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 469383000618 active site pocket [active] 469383000619 oxyanion hole [active] 469383000620 catalytic triad [active] 469383000621 active site nucleophile [active] 469383000622 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383000623 Cytochrome P450; Region: p450; cl12078 469383000624 MMPL family; Region: MMPL; pfam03176 469383000625 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 469383000626 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 469383000627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383000628 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383000629 DNA binding residues [nucleotide binding] 469383000630 dimerization interface [polypeptide binding]; other site 469383000631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383000632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383000633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383000635 putative substrate translocation pore; other site 469383000636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000637 TrkA-N domain; Region: TrkA_N; pfam02254 469383000638 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 469383000639 putative active site [active] 469383000640 RNHCP domain; Region: RNHCP; pfam12647 469383000641 Family description; Region: VCBS; pfam13517 469383000642 Family description; Region: VCBS; pfam13517 469383000643 Family description; Region: VCBS; pfam13517 469383000644 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383000645 putative hydrophobic ligand binding site [chemical binding]; other site 469383000646 PRC-barrel domain; Region: PRC; pfam05239 469383000647 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383000648 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 469383000649 metal binding site [ion binding]; metal-binding site 469383000650 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 469383000651 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383000652 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383000653 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383000654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383000655 S-adenosylmethionine binding site [chemical binding]; other site 469383000656 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383000657 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 469383000658 FtsX-like permease family; Region: FtsX; pfam02687 469383000659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383000660 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383000661 Walker A/P-loop; other site 469383000662 ATP binding site [chemical binding]; other site 469383000663 Q-loop/lid; other site 469383000664 ABC transporter signature motif; other site 469383000665 Walker B; other site 469383000666 D-loop; other site 469383000667 H-loop/switch region; other site 469383000668 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383000669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383000670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383000671 dimerization interface [polypeptide binding]; other site 469383000672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383000673 dimer interface [polypeptide binding]; other site 469383000674 phosphorylation site [posttranslational modification] 469383000675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383000676 ATP binding site [chemical binding]; other site 469383000677 Mg2+ binding site [ion binding]; other site 469383000678 G-X-G motif; other site 469383000679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383000680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000681 active site 469383000682 phosphorylation site [posttranslational modification] 469383000683 intermolecular recognition site; other site 469383000684 dimerization interface [polypeptide binding]; other site 469383000685 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383000686 DNA binding site [nucleotide binding] 469383000687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383000688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383000689 non-specific DNA binding site [nucleotide binding]; other site 469383000690 salt bridge; other site 469383000691 sequence-specific DNA binding site [nucleotide binding]; other site 469383000692 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 469383000693 SnoaL-like domain; Region: SnoaL_3; pfam13474 469383000694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383000695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383000696 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383000697 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383000698 active site 469383000699 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 469383000700 active site 469383000701 catalytic residues [active] 469383000702 metal binding site [ion binding]; metal-binding site 469383000703 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 469383000704 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 469383000705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383000706 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 469383000707 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 469383000708 carboxyltransferase (CT) interaction site; other site 469383000709 biotinylation site [posttranslational modification]; other site 469383000710 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 469383000711 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 469383000712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383000713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000714 dimer interface [polypeptide binding]; other site 469383000715 conserved gate region; other site 469383000716 putative PBP binding loops; other site 469383000717 ABC-ATPase subunit interface; other site 469383000718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383000719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000720 dimer interface [polypeptide binding]; other site 469383000721 conserved gate region; other site 469383000722 putative PBP binding loops; other site 469383000723 ABC-ATPase subunit interface; other site 469383000724 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383000725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383000726 AMP-binding domain protein; Validated; Region: PRK08315 469383000727 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383000728 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 469383000729 acyl-activating enzyme (AAE) consensus motif; other site 469383000730 putative AMP binding site [chemical binding]; other site 469383000731 putative active site [active] 469383000732 putative CoA binding site [chemical binding]; other site 469383000733 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 469383000734 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 469383000735 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 469383000736 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 469383000737 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 469383000738 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383000739 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383000740 Walker A/P-loop; other site 469383000741 ATP binding site [chemical binding]; other site 469383000742 Q-loop/lid; other site 469383000743 ABC transporter signature motif; other site 469383000744 Walker B; other site 469383000745 D-loop; other site 469383000746 H-loop/switch region; other site 469383000747 translocation protein TolB; Provisional; Region: tolB; PRK04922 469383000748 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 469383000749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383000750 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383000751 S-adenosylmethionine binding site [chemical binding]; other site 469383000752 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 469383000753 putative hydrophobic ligand binding site [chemical binding]; other site 469383000754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383000755 putative DNA binding site [nucleotide binding]; other site 469383000756 putative Zn2+ binding site [ion binding]; other site 469383000757 Predicted membrane protein [Function unknown]; Region: COG2311 469383000758 Protein of unknown function (DUF418); Region: DUF418; cl12135 469383000759 Protein of unknown function (DUF418); Region: DUF418; pfam04235 469383000760 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383000761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000762 active site 469383000763 phosphorylation site [posttranslational modification] 469383000764 intermolecular recognition site; other site 469383000765 dimerization interface [polypeptide binding]; other site 469383000766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383000767 DNA binding residues [nucleotide binding] 469383000768 dimerization interface [polypeptide binding]; other site 469383000769 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 469383000770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000771 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383000772 putative substrate translocation pore; other site 469383000773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383000776 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 469383000777 active site triad [active] 469383000778 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 469383000779 Histidine kinase; Region: HisKA_3; pfam07730 469383000780 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383000781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383000782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000783 active site 469383000784 phosphorylation site [posttranslational modification] 469383000785 intermolecular recognition site; other site 469383000786 dimerization interface [polypeptide binding]; other site 469383000787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383000788 DNA binding residues [nucleotide binding] 469383000789 dimerization interface [polypeptide binding]; other site 469383000790 Predicted esterase [General function prediction only]; Region: COG0400 469383000791 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 469383000792 Domain of unknown function (DUF385); Region: DUF385; pfam04075 469383000793 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 469383000794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383000795 ATP binding site [chemical binding]; other site 469383000796 putative Mg++ binding site [ion binding]; other site 469383000797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383000798 nucleotide binding region [chemical binding]; other site 469383000799 ATP-binding site [chemical binding]; other site 469383000800 Helicase associated domain (HA2); Region: HA2; pfam04408 469383000801 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 469383000802 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 469383000803 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 469383000804 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 469383000805 siderophore binding site; other site 469383000806 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 469383000807 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 469383000808 Walker A/P-loop; other site 469383000809 ATP binding site [chemical binding]; other site 469383000810 Q-loop/lid; other site 469383000811 ABC transporter signature motif; other site 469383000812 Walker B; other site 469383000813 D-loop; other site 469383000814 H-loop/switch region; other site 469383000815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383000816 conserved gate region; other site 469383000817 ABC-ATPase subunit interface; other site 469383000818 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 469383000819 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 469383000820 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 469383000821 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383000822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383000823 catalytic residue [active] 469383000824 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 469383000825 catalytic triad [active] 469383000826 putative active site [active] 469383000827 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383000828 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383000829 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 469383000830 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383000831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383000832 DNA-binding site [nucleotide binding]; DNA binding site 469383000833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383000834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383000835 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 469383000836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383000837 Walker A/P-loop; other site 469383000838 ATP binding site [chemical binding]; other site 469383000839 Q-loop/lid; other site 469383000840 ABC transporter signature motif; other site 469383000841 Walker B; other site 469383000842 D-loop; other site 469383000843 H-loop/switch region; other site 469383000844 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383000845 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 469383000846 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 469383000847 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 469383000848 heme-binding site [chemical binding]; other site 469383000849 HTH domain; Region: HTH_11; cl17392 469383000850 WYL domain; Region: WYL; pfam13280 469383000851 Epoxide hydrolase N terminus; Region: EHN; pfam06441 469383000852 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383000853 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 469383000854 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 469383000855 Winged helix-turn helix; Region: HTH_29; pfam13551 469383000856 Integrase core domain; Region: rve; pfam00665 469383000857 Integrase core domain; Region: rve_3; pfam13683 469383000858 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 469383000859 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 469383000860 putative active site [active] 469383000861 putative metal binding site [ion binding]; other site 469383000862 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383000863 MarR family; Region: MarR; pfam01047 469383000864 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 469383000865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383000866 dimerization interface [polypeptide binding]; other site 469383000867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383000868 dimer interface [polypeptide binding]; other site 469383000869 phosphorylation site [posttranslational modification] 469383000870 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 469383000871 Mg2+ binding site [ion binding]; other site 469383000872 G-X-G motif; other site 469383000873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383000874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000875 active site 469383000876 phosphorylation site [posttranslational modification] 469383000877 intermolecular recognition site; other site 469383000878 dimerization interface [polypeptide binding]; other site 469383000879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383000880 DNA binding site [nucleotide binding] 469383000881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383000882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000883 active site 469383000884 phosphorylation site [posttranslational modification] 469383000885 intermolecular recognition site; other site 469383000886 dimerization interface [polypeptide binding]; other site 469383000887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383000888 DNA binding site [nucleotide binding] 469383000889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383000890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383000891 dimerization interface [polypeptide binding]; other site 469383000892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383000893 dimer interface [polypeptide binding]; other site 469383000894 phosphorylation site [posttranslational modification] 469383000895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383000896 ATP binding site [chemical binding]; other site 469383000897 Mg2+ binding site [ion binding]; other site 469383000898 G-X-G motif; other site 469383000899 Cupin domain; Region: Cupin_2; cl17218 469383000900 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383000901 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 469383000902 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383000903 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383000904 Walker A/P-loop; other site 469383000905 ATP binding site [chemical binding]; other site 469383000906 Q-loop/lid; other site 469383000907 ABC transporter signature motif; other site 469383000908 Walker B; other site 469383000909 D-loop; other site 469383000910 H-loop/switch region; other site 469383000911 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 469383000912 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 469383000913 beta-ketothiolase; Provisional; Region: PRK09051 469383000914 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383000915 dimer interface [polypeptide binding]; other site 469383000916 active site 469383000917 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469383000918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469383000919 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 469383000920 Walker A/P-loop; other site 469383000921 ATP binding site [chemical binding]; other site 469383000922 Q-loop/lid; other site 469383000923 ABC transporter signature motif; other site 469383000924 Walker B; other site 469383000925 D-loop; other site 469383000926 H-loop/switch region; other site 469383000927 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 469383000928 MMPL family; Region: MMPL; pfam03176 469383000929 MMPL family; Region: MMPL; pfam03176 469383000930 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 469383000931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383000933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383000934 putative DNA binding site [nucleotide binding]; other site 469383000935 putative Zn2+ binding site [ion binding]; other site 469383000936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383000937 dimerization interface [polypeptide binding]; other site 469383000938 putative DNA binding site [nucleotide binding]; other site 469383000939 putative Zn2+ binding site [ion binding]; other site 469383000940 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383000941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383000942 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 469383000943 putative active site [active] 469383000944 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 469383000945 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383000946 ATP binding site [chemical binding]; other site 469383000947 putative Mg++ binding site [ion binding]; other site 469383000948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383000949 nucleotide binding region [chemical binding]; other site 469383000950 ATP-binding site [chemical binding]; other site 469383000951 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 469383000952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383000953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000954 active site 469383000955 phosphorylation site [posttranslational modification] 469383000956 intermolecular recognition site; other site 469383000957 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383000958 DNA binding residues [nucleotide binding] 469383000959 PAS domain; Region: PAS_9; pfam13426 469383000960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383000961 putative active site [active] 469383000962 heme pocket [chemical binding]; other site 469383000963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383000964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383000965 ATP binding site [chemical binding]; other site 469383000966 Mg2+ binding site [ion binding]; other site 469383000967 G-X-G motif; other site 469383000968 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383000969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383000970 active site 469383000971 phosphorylation site [posttranslational modification] 469383000972 intermolecular recognition site; other site 469383000973 dimerization interface [polypeptide binding]; other site 469383000974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383000975 DNA binding residues [nucleotide binding] 469383000976 dimerization interface [polypeptide binding]; other site 469383000977 Phosphotransferase enzyme family; Region: APH; pfam01636 469383000978 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383000979 active site 469383000980 ATP binding site [chemical binding]; other site 469383000981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000982 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383000983 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383000984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383000985 active site 469383000986 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383000987 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 469383000988 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383000989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383000990 catalytic residue [active] 469383000991 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 469383000992 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383000993 putative hydrophobic ligand binding site [chemical binding]; other site 469383000994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469383000995 RNA binding surface [nucleotide binding]; other site 469383000996 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 469383000997 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 469383000998 Multicopper oxidase; Region: Cu-oxidase; pfam00394 469383000999 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 469383001000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383001001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383001002 non-specific DNA binding site [nucleotide binding]; other site 469383001003 salt bridge; other site 469383001004 sequence-specific DNA binding site [nucleotide binding]; other site 469383001005 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 469383001006 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 469383001007 ParB-like nuclease domain; Region: ParBc; pfam02195 469383001008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001010 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383001011 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 469383001012 acyl-CoA synthetase; Validated; Region: PRK07788 469383001013 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383001014 acyl-activating enzyme (AAE) consensus motif; other site 469383001015 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383001016 AMP binding site [chemical binding]; other site 469383001017 active site 469383001018 acyl-activating enzyme (AAE) consensus motif; other site 469383001019 CoA binding site [chemical binding]; other site 469383001020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383001021 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 469383001022 active site 469383001023 catalytic residues [active] 469383001024 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 469383001025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383001026 DNA-binding site [nucleotide binding]; DNA binding site 469383001027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383001028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383001029 homodimer interface [polypeptide binding]; other site 469383001030 catalytic residue [active] 469383001031 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 469383001032 EamA-like transporter family; Region: EamA; pfam00892 469383001033 cytosine deaminase; Validated; Region: PRK07572 469383001034 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 469383001035 active site 469383001036 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 469383001037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383001038 DNA-binding site [nucleotide binding]; DNA binding site 469383001039 FCD domain; Region: FCD; cl11656 469383001040 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383001041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001042 putative substrate translocation pore; other site 469383001043 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383001044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383001045 active site 469383001046 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383001047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383001048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 469383001049 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 469383001050 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 469383001051 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 469383001052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383001053 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469383001054 dimerization interface [polypeptide binding]; other site 469383001055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001057 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 469383001058 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383001059 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383001060 Cytochrome P450; Region: p450; cl12078 469383001061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383001063 active site 469383001064 phosphorylation site [posttranslational modification] 469383001065 intermolecular recognition site; other site 469383001066 dimerization interface [polypeptide binding]; other site 469383001067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001068 DNA binding residues [nucleotide binding] 469383001069 dimerization interface [polypeptide binding]; other site 469383001070 Histidine kinase; Region: HisKA_3; pfam07730 469383001071 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383001072 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 469383001073 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 469383001074 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383001075 NAD(P) binding site [chemical binding]; other site 469383001076 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 469383001077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383001078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383001079 DNA binding residues [nucleotide binding] 469383001080 RNA polymerase factor sigma-70; Validated; Region: PRK08241 469383001081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383001082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383001083 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383001084 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 469383001085 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 469383001086 putative active site; other site 469383001087 catalytic residue [active] 469383001088 PA14 domain; Region: PA14; cl08459 469383001089 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 469383001090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383001092 active site 469383001093 phosphorylation site [posttranslational modification] 469383001094 intermolecular recognition site; other site 469383001095 dimerization interface [polypeptide binding]; other site 469383001096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001097 dimerization interface [polypeptide binding]; other site 469383001098 DNA binding residues [nucleotide binding] 469383001099 Histidine kinase; Region: HisKA_3; pfam07730 469383001100 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383001101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001102 Walker A/P-loop; other site 469383001103 ATP binding site [chemical binding]; other site 469383001104 ABC transporter; Region: ABC_tran; pfam00005 469383001105 Q-loop/lid; other site 469383001106 ABC transporter signature motif; other site 469383001107 Walker B; other site 469383001108 D-loop; other site 469383001109 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 469383001110 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383001111 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383001112 metal binding site [ion binding]; metal-binding site 469383001113 substrate binding pocket [chemical binding]; other site 469383001114 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383001115 classical (c) SDRs; Region: SDR_c; cd05233 469383001116 NAD(P) binding site [chemical binding]; other site 469383001117 active site 469383001118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383001119 dimerization interface [polypeptide binding]; other site 469383001120 putative DNA binding site [nucleotide binding]; other site 469383001121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383001122 putative Zn2+ binding site [ion binding]; other site 469383001123 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383001124 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383001125 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383001126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001127 dimer interface [polypeptide binding]; other site 469383001128 conserved gate region; other site 469383001129 putative PBP binding loops; other site 469383001130 ABC-ATPase subunit interface; other site 469383001131 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383001132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001133 putative PBP binding loops; other site 469383001134 dimer interface [polypeptide binding]; other site 469383001135 ABC-ATPase subunit interface; other site 469383001136 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383001137 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383001138 Walker A/P-loop; other site 469383001139 ATP binding site [chemical binding]; other site 469383001140 Q-loop/lid; other site 469383001141 ABC transporter signature motif; other site 469383001142 Walker B; other site 469383001143 D-loop; other site 469383001144 H-loop/switch region; other site 469383001145 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 469383001146 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383001147 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 469383001148 active site 469383001149 DNA binding site [nucleotide binding] 469383001150 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 469383001151 YCII-related domain; Region: YCII; cl00999 469383001152 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 469383001153 hydrophobic ligand binding site; other site 469383001154 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 469383001155 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383001156 DNA binding residues [nucleotide binding] 469383001157 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 469383001158 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 469383001159 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383001160 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469383001161 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383001162 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383001163 active site 469383001164 metal binding site [ion binding]; metal-binding site 469383001165 AAA ATPase domain; Region: AAA_16; pfam13191 469383001166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001168 DNA binding residues [nucleotide binding] 469383001169 dimerization interface [polypeptide binding]; other site 469383001170 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 469383001171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383001172 S-adenosylmethionine binding site [chemical binding]; other site 469383001173 MarR family; Region: MarR_2; cl17246 469383001174 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383001175 EamA-like transporter family; Region: EamA; pfam00892 469383001176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383001177 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383001178 NAD(P) binding site [chemical binding]; other site 469383001179 active site 469383001180 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383001181 active site 469383001182 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383001183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383001184 DNA-binding site [nucleotide binding]; DNA binding site 469383001185 FCD domain; Region: FCD; pfam07729 469383001186 RibD C-terminal domain; Region: RibD_C; cl17279 469383001187 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383001188 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 469383001189 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 469383001190 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383001191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383001192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383001193 DNA binding residues [nucleotide binding] 469383001194 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383001195 Cytochrome P450; Region: p450; cl12078 469383001196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001198 Amidase; Region: Amidase; cl11426 469383001199 AAA ATPase domain; Region: AAA_16; pfam13191 469383001200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001202 DNA binding residues [nucleotide binding] 469383001203 dimerization interface [polypeptide binding]; other site 469383001204 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 469383001205 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 469383001206 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 469383001207 dimerization interface [polypeptide binding]; other site 469383001208 ATP binding site [chemical binding]; other site 469383001209 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 469383001210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001211 putative substrate translocation pore; other site 469383001212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383001215 NAD(P) binding site [chemical binding]; other site 469383001216 active site 469383001217 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383001218 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383001219 active site 469383001220 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 469383001221 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 469383001222 acyl-activating enzyme (AAE) consensus motif; other site 469383001223 putative AMP binding site [chemical binding]; other site 469383001224 putative active site [active] 469383001225 putative CoA binding site [chemical binding]; other site 469383001226 Right handed beta helix region; Region: Beta_helix; pfam13229 469383001227 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469383001228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001229 ABC transporter signature motif; other site 469383001230 Walker B; other site 469383001231 D-loop; other site 469383001232 H-loop/switch region; other site 469383001233 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469383001234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001236 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 469383001237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001240 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383001241 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 469383001242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001244 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383001245 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 469383001246 inhibitor-cofactor binding pocket; inhibition site 469383001247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383001248 catalytic residue [active] 469383001249 biotin synthase; Validated; Region: PRK06256 469383001250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383001251 FeS/SAM binding site; other site 469383001252 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 469383001253 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 469383001254 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 469383001255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383001256 catalytic residue [active] 469383001257 BNR repeat-like domain; Region: BNR_2; pfam13088 469383001258 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 469383001259 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469383001260 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383001261 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383001262 Walker A/P-loop; other site 469383001263 ATP binding site [chemical binding]; other site 469383001264 Q-loop/lid; other site 469383001265 ABC transporter signature motif; other site 469383001266 Walker B; other site 469383001267 D-loop; other site 469383001268 H-loop/switch region; other site 469383001269 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383001270 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383001271 Walker A/P-loop; other site 469383001272 ATP binding site [chemical binding]; other site 469383001273 Q-loop/lid; other site 469383001274 ABC transporter signature motif; other site 469383001275 Walker B; other site 469383001276 D-loop; other site 469383001277 H-loop/switch region; other site 469383001278 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383001279 TM-ABC transporter signature motif; other site 469383001280 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383001281 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383001282 TM-ABC transporter signature motif; other site 469383001283 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 469383001284 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 469383001285 putative ligand binding site [chemical binding]; other site 469383001286 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 469383001287 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383001288 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383001289 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 469383001290 [2Fe-2S] cluster binding site [ion binding]; other site 469383001291 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 469383001292 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 469383001293 [2Fe-2S] cluster binding site [ion binding]; other site 469383001294 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 469383001295 beta subunit interface [polypeptide binding]; other site 469383001296 alpha subunit interface [polypeptide binding]; other site 469383001297 active site 469383001298 substrate binding site [chemical binding]; other site 469383001299 Fe binding site [ion binding]; other site 469383001300 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 469383001301 inter-subunit interface; other site 469383001302 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 469383001303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383001304 NAD(P) binding site [chemical binding]; other site 469383001305 active site 469383001306 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 469383001307 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 469383001308 FMN binding site [chemical binding]; other site 469383001309 substrate binding site [chemical binding]; other site 469383001310 putative catalytic residue [active] 469383001311 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 469383001312 acetaldehyde dehydrogenase; Validated; Region: PRK08300 469383001313 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 469383001314 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 469383001315 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 469383001316 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 469383001317 active site 469383001318 catalytic residues [active] 469383001319 metal binding site [ion binding]; metal-binding site 469383001320 DmpG-like communication domain; Region: DmpG_comm; pfam07836 469383001321 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 469383001322 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383001323 acyl-activating enzyme (AAE) consensus motif; other site 469383001324 AMP binding site [chemical binding]; other site 469383001325 active site 469383001326 CoA binding site [chemical binding]; other site 469383001327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 469383001328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383001329 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 469383001330 tetramer interface [polypeptide binding]; other site 469383001331 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 469383001332 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 469383001333 tetramer interface [polypeptide binding]; other site 469383001334 active site 469383001335 metal binding site [ion binding]; metal-binding site 469383001336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001340 DNA binding residues [nucleotide binding] 469383001341 dimerization interface [polypeptide binding]; other site 469383001342 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383001343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001344 putative substrate translocation pore; other site 469383001345 glutamine synthetase, type I; Region: GlnA; TIGR00653 469383001346 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 469383001347 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 469383001348 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 469383001349 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 469383001350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 469383001351 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 469383001352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001354 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 469383001355 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 469383001356 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 469383001357 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383001358 catalytic residue [active] 469383001359 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383001360 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383001361 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383001362 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383001363 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383001364 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383001365 Walker A/P-loop; other site 469383001366 ATP binding site [chemical binding]; other site 469383001367 Q-loop/lid; other site 469383001368 ABC transporter signature motif; other site 469383001369 Walker B; other site 469383001370 D-loop; other site 469383001371 H-loop/switch region; other site 469383001372 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383001373 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383001374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383001375 Walker A/P-loop; other site 469383001376 ATP binding site [chemical binding]; other site 469383001377 Q-loop/lid; other site 469383001378 ABC transporter signature motif; other site 469383001379 Walker B; other site 469383001380 D-loop; other site 469383001381 H-loop/switch region; other site 469383001382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383001383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001384 dimer interface [polypeptide binding]; other site 469383001385 conserved gate region; other site 469383001386 putative PBP binding loops; other site 469383001387 ABC-ATPase subunit interface; other site 469383001388 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383001389 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383001390 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383001391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001392 putative PBP binding loops; other site 469383001393 dimer interface [polypeptide binding]; other site 469383001394 ABC-ATPase subunit interface; other site 469383001395 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 469383001396 catalytic triad [active] 469383001397 conserved cis-peptide bond; other site 469383001398 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 469383001399 oligomeric interface; other site 469383001400 putative active site [active] 469383001401 homodimer interface [polypeptide binding]; other site 469383001402 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 469383001403 Predicted acyl esterases [General function prediction only]; Region: COG2936 469383001404 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383001405 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383001406 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 469383001407 CGNR zinc finger; Region: zf-CGNR; pfam11706 469383001408 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 469383001409 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 469383001410 putative homodimer interface [polypeptide binding]; other site 469383001411 putative homotetramer interface [polypeptide binding]; other site 469383001412 putative allosteric switch controlling residues; other site 469383001413 putative metal binding site [ion binding]; other site 469383001414 putative homodimer-homodimer interface [polypeptide binding]; other site 469383001415 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 469383001416 metal-binding site [ion binding] 469383001417 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 469383001418 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 469383001419 metal-binding site [ion binding] 469383001420 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 469383001421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383001422 motif II; other site 469383001423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383001424 ATP binding site [chemical binding]; other site 469383001425 putative Mg++ binding site [ion binding]; other site 469383001426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383001427 nucleotide binding region [chemical binding]; other site 469383001428 ATP-binding site [chemical binding]; other site 469383001429 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 469383001430 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383001431 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383001432 YCII-related domain; Region: YCII; cl00999 469383001433 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 469383001434 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383001435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383001436 S-adenosylmethionine binding site [chemical binding]; other site 469383001437 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 469383001438 active site 469383001439 substrate binding sites [chemical binding]; other site 469383001440 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 469383001441 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 469383001442 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 469383001443 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 469383001444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001446 WHG domain; Region: WHG; pfam13305 469383001447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383001448 S-adenosylmethionine binding site [chemical binding]; other site 469383001449 RibD C-terminal domain; Region: RibD_C; cl17279 469383001450 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 469383001451 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383001452 putative hydrophobic ligand binding site [chemical binding]; other site 469383001453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383001454 dimerization interface [polypeptide binding]; other site 469383001455 putative DNA binding site [nucleotide binding]; other site 469383001456 putative Zn2+ binding site [ion binding]; other site 469383001457 malate dehydrogenase; Provisional; Region: PRK13529 469383001458 Malic enzyme, N-terminal domain; Region: malic; pfam00390 469383001459 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 469383001460 NAD(P) binding pocket [chemical binding]; other site 469383001461 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 469383001462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383001463 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383001464 DNA binding residues [nucleotide binding] 469383001465 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 469383001466 Uncharacterized conserved protein [Function unknown]; Region: COG2128 469383001467 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383001468 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383001469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383001470 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 469383001471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001472 Walker A/P-loop; other site 469383001473 ATP binding site [chemical binding]; other site 469383001474 Q-loop/lid; other site 469383001475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001476 ABC transporter signature motif; other site 469383001477 Walker B; other site 469383001478 D-loop; other site 469383001479 H-loop/switch region; other site 469383001480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001481 Walker A/P-loop; other site 469383001482 ATP binding site [chemical binding]; other site 469383001483 Q-loop/lid; other site 469383001484 ABC transporter signature motif; other site 469383001485 Walker B; other site 469383001486 D-loop; other site 469383001487 H-loop/switch region; other site 469383001488 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 469383001489 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 469383001490 Zn binding site [ion binding]; other site 469383001491 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 469383001492 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 469383001493 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 469383001494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383001495 S-adenosylmethionine binding site [chemical binding]; other site 469383001496 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383001497 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383001498 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383001499 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383001500 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383001501 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383001502 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383001503 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383001504 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383001506 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 469383001507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383001508 substrate binding site [chemical binding]; other site 469383001509 oxyanion hole (OAH) forming residues; other site 469383001510 trimer interface [polypeptide binding]; other site 469383001511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001513 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 469383001514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383001515 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 469383001516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001517 dimer interface [polypeptide binding]; other site 469383001518 conserved gate region; other site 469383001519 putative PBP binding loops; other site 469383001520 ABC-ATPase subunit interface; other site 469383001521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001522 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 469383001523 Walker A/P-loop; other site 469383001524 ATP binding site [chemical binding]; other site 469383001525 Q-loop/lid; other site 469383001526 ABC transporter signature motif; other site 469383001527 Walker B; other site 469383001528 D-loop; other site 469383001529 H-loop/switch region; other site 469383001530 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 469383001531 Helix-turn-helix domain; Region: HTH_18; pfam12833 469383001532 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 469383001533 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383001534 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 469383001535 Domain of unknown function (DUF385); Region: DUF385; cl04387 469383001536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383001538 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 469383001539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001540 Lipase (class 2); Region: Lipase_2; pfam01674 469383001541 MEKHLA domain; Region: MEKHLA; pfam08670 469383001542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383001543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383001544 dimerization interface [polypeptide binding]; other site 469383001545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383001546 dimer interface [polypeptide binding]; other site 469383001547 phosphorylation site [posttranslational modification] 469383001548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383001549 ATP binding site [chemical binding]; other site 469383001550 G-X-G motif; other site 469383001551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383001552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383001553 active site 469383001554 phosphorylation site [posttranslational modification] 469383001555 intermolecular recognition site; other site 469383001556 dimerization interface [polypeptide binding]; other site 469383001557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383001558 DNA binding site [nucleotide binding] 469383001559 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 469383001560 cleavage site 469383001561 active site 469383001562 substrate binding sites [chemical binding]; other site 469383001563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 469383001564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001565 DNA binding residues [nucleotide binding] 469383001566 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383001567 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383001568 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383001569 active site 469383001570 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 469383001571 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383001572 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 469383001573 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383001574 TM-ABC transporter signature motif; other site 469383001575 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383001576 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 469383001577 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 469383001578 TM-ABC transporter signature motif; other site 469383001579 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 469383001580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383001581 Amidase; Region: Amidase; cl11426 469383001582 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383001583 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383001584 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383001585 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 469383001586 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383001587 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383001588 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 469383001589 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383001590 Walker A/P-loop; other site 469383001591 ATP binding site [chemical binding]; other site 469383001592 Q-loop/lid; other site 469383001593 ABC transporter signature motif; other site 469383001594 Walker B; other site 469383001595 D-loop; other site 469383001596 H-loop/switch region; other site 469383001597 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383001598 haloalkane dehalogenase; Provisional; Region: PRK03592 469383001599 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383001600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383001601 NAD(P) binding site [chemical binding]; other site 469383001602 catalytic residues [active] 469383001603 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383001604 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 469383001605 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 469383001606 ligand binding site [chemical binding]; other site 469383001607 NAD binding site [chemical binding]; other site 469383001608 catalytic site [active] 469383001609 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383001610 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383001611 Right handed beta helix region; Region: Beta_helix; pfam13229 469383001612 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383001613 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 469383001614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001615 Walker A/P-loop; other site 469383001616 ATP binding site [chemical binding]; other site 469383001617 Q-loop/lid; other site 469383001618 ABC transporter signature motif; other site 469383001619 Walker B; other site 469383001620 D-loop; other site 469383001621 H-loop/switch region; other site 469383001622 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383001623 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383001624 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 469383001625 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383001626 DNA binding residues [nucleotide binding] 469383001627 dimer interface [polypeptide binding]; other site 469383001628 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 469383001629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383001630 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 469383001631 dimerization interface [polypeptide binding]; other site 469383001632 substrate binding pocket [chemical binding]; other site 469383001633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383001634 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 469383001635 active site 469383001636 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 469383001637 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 469383001638 ligand binding site [chemical binding]; other site 469383001639 homodimer interface [polypeptide binding]; other site 469383001640 NAD(P) binding site [chemical binding]; other site 469383001641 trimer interface B [polypeptide binding]; other site 469383001642 trimer interface A [polypeptide binding]; other site 469383001643 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 469383001644 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 469383001645 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 469383001646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383001648 active site 469383001649 phosphorylation site [posttranslational modification] 469383001650 intermolecular recognition site; other site 469383001651 dimerization interface [polypeptide binding]; other site 469383001652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001653 DNA binding residues [nucleotide binding] 469383001654 dimerization interface [polypeptide binding]; other site 469383001655 Histidine kinase; Region: HisKA_3; pfam07730 469383001656 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383001657 MMPL family; Region: MMPL; pfam03176 469383001658 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383001659 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001661 DNA binding residues [nucleotide binding] 469383001662 dimerization interface [polypeptide binding]; other site 469383001663 Right handed beta helix region; Region: Beta_helix; pfam13229 469383001664 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 469383001665 classical (c) SDRs; Region: SDR_c; cd05233 469383001666 NAD(P) binding site [chemical binding]; other site 469383001667 active site 469383001668 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383001669 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383001670 ligand binding site [chemical binding]; other site 469383001671 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383001672 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383001673 Walker A/P-loop; other site 469383001674 ATP binding site [chemical binding]; other site 469383001675 Q-loop/lid; other site 469383001676 ABC transporter signature motif; other site 469383001677 Walker B; other site 469383001678 D-loop; other site 469383001679 H-loop/switch region; other site 469383001680 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383001681 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383001682 TM-ABC transporter signature motif; other site 469383001683 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383001684 classical (c) SDRs; Region: SDR_c; cd05233 469383001685 NAD(P) binding site [chemical binding]; other site 469383001686 active site 469383001687 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 469383001688 Amidohydrolase; Region: Amidohydro_2; pfam04909 469383001689 Domain of unknown function (DUF718); Region: DUF718; cl01281 469383001690 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383001691 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383001692 active site 469383001693 metal binding site [ion binding]; metal-binding site 469383001694 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383001695 tetramer interface [polypeptide binding]; other site 469383001696 TPP-binding site [chemical binding]; other site 469383001697 heterodimer interface [polypeptide binding]; other site 469383001698 phosphorylation loop region [posttranslational modification] 469383001699 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383001700 alpha subunit interface [polypeptide binding]; other site 469383001701 heterodimer interface [polypeptide binding]; other site 469383001702 TPP binding site [chemical binding]; other site 469383001703 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383001704 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 469383001705 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383001706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001707 dimer interface [polypeptide binding]; other site 469383001708 conserved gate region; other site 469383001709 putative PBP binding loops; other site 469383001710 ABC-ATPase subunit interface; other site 469383001711 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383001712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001713 dimer interface [polypeptide binding]; other site 469383001714 conserved gate region; other site 469383001715 putative PBP binding loops; other site 469383001716 ABC-ATPase subunit interface; other site 469383001717 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383001718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383001719 Walker A/P-loop; other site 469383001720 ATP binding site [chemical binding]; other site 469383001721 Q-loop/lid; other site 469383001722 ABC transporter signature motif; other site 469383001723 Walker B; other site 469383001724 D-loop; other site 469383001725 H-loop/switch region; other site 469383001726 TOBE domain; Region: TOBE_2; pfam08402 469383001727 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383001728 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383001729 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383001730 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383001731 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383001732 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383001733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383001734 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 469383001735 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383001736 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383001737 Amidase; Region: Amidase; cl11426 469383001738 Amidase; Region: Amidase; cl11426 469383001739 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 469383001740 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383001741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383001742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383001743 dimer interface [polypeptide binding]; other site 469383001744 conserved gate region; other site 469383001745 putative PBP binding loops; other site 469383001746 ABC-ATPase subunit interface; other site 469383001747 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383001748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 469383001749 ABC-ATPase subunit interface; other site 469383001750 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383001751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383001752 Walker A/P-loop; other site 469383001753 ATP binding site [chemical binding]; other site 469383001754 Q-loop/lid; other site 469383001755 ABC transporter signature motif; other site 469383001756 Walker B; other site 469383001757 D-loop; other site 469383001758 H-loop/switch region; other site 469383001759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383001760 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383001761 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383001762 Walker A/P-loop; other site 469383001763 ATP binding site [chemical binding]; other site 469383001764 Q-loop/lid; other site 469383001765 ABC transporter signature motif; other site 469383001766 Walker B; other site 469383001767 D-loop; other site 469383001768 H-loop/switch region; other site 469383001769 Htaa; Region: HtaA; pfam04213 469383001770 Htaa; Region: HtaA; pfam04213 469383001771 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383001772 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383001773 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 469383001774 FtsX-like permease family; Region: FtsX; pfam02687 469383001775 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383001776 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383001777 Walker A/P-loop; other site 469383001778 ATP binding site [chemical binding]; other site 469383001779 Q-loop/lid; other site 469383001780 ABC transporter signature motif; other site 469383001781 Walker B; other site 469383001782 D-loop; other site 469383001783 H-loop/switch region; other site 469383001784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383001785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383001786 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 469383001787 Low molecular weight phosphatase family; Region: LMWPc; cl00105 469383001788 active site 469383001789 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 469383001790 arsenical-resistance protein; Region: acr3; TIGR00832 469383001791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383001792 dimerization interface [polypeptide binding]; other site 469383001793 putative DNA binding site [nucleotide binding]; other site 469383001794 putative Zn2+ binding site [ion binding]; other site 469383001795 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383001796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383001797 S-adenosylmethionine binding site [chemical binding]; other site 469383001798 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 469383001799 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 469383001800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383001801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383001802 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 469383001803 putative dimerization interface [polypeptide binding]; other site 469383001804 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383001805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383001806 S-adenosylmethionine binding site [chemical binding]; other site 469383001807 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 469383001808 HI0933-like protein; Region: HI0933_like; pfam03486 469383001809 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 469383001810 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383001811 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383001812 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 469383001813 cyclase homology domain; Region: CHD; cd07302 469383001814 nucleotidyl binding site; other site 469383001815 metal binding site [ion binding]; metal-binding site 469383001816 dimer interface [polypeptide binding]; other site 469383001817 AAA ATPase domain; Region: AAA_16; pfam13191 469383001818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469383001819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469383001820 ligand binding site [chemical binding]; other site 469383001821 flexible hinge region; other site 469383001822 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 469383001823 putative switch regulator; other site 469383001824 non-specific DNA interactions [nucleotide binding]; other site 469383001825 DNA binding site [nucleotide binding] 469383001826 sequence specific DNA binding site [nucleotide binding]; other site 469383001827 putative cAMP binding site [chemical binding]; other site 469383001828 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 469383001829 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 469383001830 AAA ATPase domain; Region: AAA_16; pfam13191 469383001831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001832 DNA binding residues [nucleotide binding] 469383001833 dimerization interface [polypeptide binding]; other site 469383001834 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 469383001835 Ion channel; Region: Ion_trans_2; pfam07885 469383001836 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 469383001837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383001838 Walker A/P-loop; other site 469383001839 ATP binding site [chemical binding]; other site 469383001840 Q-loop/lid; other site 469383001841 ABC transporter signature motif; other site 469383001842 Walker B; other site 469383001843 D-loop; other site 469383001844 H-loop/switch region; other site 469383001845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383001846 Histidine kinase; Region: HisKA_3; pfam07730 469383001847 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383001848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383001850 active site 469383001851 phosphorylation site [posttranslational modification] 469383001852 intermolecular recognition site; other site 469383001853 dimerization interface [polypeptide binding]; other site 469383001854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001855 DNA binding residues [nucleotide binding] 469383001856 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 469383001857 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 469383001858 FAD binding site [chemical binding]; other site 469383001859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383001860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383001861 DNA binding residues [nucleotide binding] 469383001862 dimerization interface [polypeptide binding]; other site 469383001863 DAK2 domain; Region: Dak2; pfam02734 469383001864 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 469383001865 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 469383001866 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 469383001867 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 469383001868 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 469383001869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383001870 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 469383001871 inhibitor-cofactor binding pocket; inhibition site 469383001872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383001873 catalytic residue [active] 469383001874 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383001875 classical (c) SDRs; Region: SDR_c; cd05233 469383001876 NAD(P) binding site [chemical binding]; other site 469383001877 active site 469383001878 FCD domain; Region: FCD; pfam07729 469383001879 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 469383001880 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383001881 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 469383001882 NAD(P) binding pocket [chemical binding]; other site 469383001883 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 469383001884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383001885 motif II; other site 469383001886 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 469383001887 active site 469383001888 adenosine deaminase; Provisional; Region: PRK09358 469383001889 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 469383001890 active site 469383001891 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 469383001892 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 469383001893 active site 469383001894 acetylornithine deacetylase; Provisional; Region: PRK06837 469383001895 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383001896 metal binding site [ion binding]; metal-binding site 469383001897 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383001898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383001899 DNA-binding site [nucleotide binding]; DNA binding site 469383001900 FCD domain; Region: FCD; pfam07729 469383001901 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 469383001902 adenosine deaminase; Provisional; Region: PRK09358 469383001903 active site 469383001904 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 469383001905 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 469383001906 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 469383001907 ligand binding site [chemical binding]; other site 469383001908 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 469383001909 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383001910 Walker A/P-loop; other site 469383001911 ATP binding site [chemical binding]; other site 469383001912 Q-loop/lid; other site 469383001913 ABC transporter signature motif; other site 469383001914 Walker B; other site 469383001915 D-loop; other site 469383001916 H-loop/switch region; other site 469383001917 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383001918 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383001919 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 469383001920 TM-ABC transporter signature motif; other site 469383001921 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 469383001922 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383001923 TM-ABC transporter signature motif; other site 469383001924 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383001925 FAD binding domain; Region: FAD_binding_4; pfam01565 469383001926 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383001927 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383001928 active site 469383001929 Right handed beta helix region; Region: Beta_helix; pfam13229 469383001930 Right handed beta helix region; Region: Beta_helix; pfam13229 469383001931 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 469383001932 active site 469383001933 Calx-beta domain; Region: Calx-beta; cl02522 469383001934 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 469383001935 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 469383001936 Clp amino terminal domain; Region: Clp_N; pfam02861 469383001937 Clp amino terminal domain; Region: Clp_N; pfam02861 469383001938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383001939 Walker A motif; other site 469383001940 ATP binding site [chemical binding]; other site 469383001941 Walker B motif; other site 469383001942 arginine finger; other site 469383001943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383001944 Walker A motif; other site 469383001945 ATP binding site [chemical binding]; other site 469383001946 Walker B motif; other site 469383001947 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 469383001948 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 469383001949 HSP70 interaction site [polypeptide binding]; other site 469383001950 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 469383001951 dimer interface [polypeptide binding]; other site 469383001952 GrpE; Region: GrpE; pfam01025 469383001953 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 469383001954 dimer interface [polypeptide binding]; other site 469383001955 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 469383001956 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 469383001957 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 469383001958 nucleotide binding site [chemical binding]; other site 469383001959 NEF interaction site [polypeptide binding]; other site 469383001960 SBD interface [polypeptide binding]; other site 469383001961 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 469383001962 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383001963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383001964 DNA binding residues [nucleotide binding] 469383001965 thioredoxin 2; Provisional; Region: PRK10996 469383001966 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 469383001967 catalytic residues [active] 469383001968 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469383001969 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469383001970 ligand binding site [chemical binding]; other site 469383001971 flexible hinge region; other site 469383001972 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383001973 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 469383001974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383001975 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 469383001976 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 469383001977 active site 469383001978 Mn binding site [ion binding]; other site 469383001979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383001980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383001981 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 469383001982 putative dimerization interface [polypeptide binding]; other site 469383001983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383001984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383001985 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 469383001986 putative dimerization interface [polypeptide binding]; other site 469383001987 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383001988 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383001989 TM-ABC transporter signature motif; other site 469383001990 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383001991 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383001992 TM-ABC transporter signature motif; other site 469383001993 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383001994 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383001995 Walker A/P-loop; other site 469383001996 ATP binding site [chemical binding]; other site 469383001997 Q-loop/lid; other site 469383001998 ABC transporter signature motif; other site 469383001999 Walker B; other site 469383002000 D-loop; other site 469383002001 H-loop/switch region; other site 469383002002 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383002003 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383002004 Walker A/P-loop; other site 469383002005 ATP binding site [chemical binding]; other site 469383002006 Q-loop/lid; other site 469383002007 ABC transporter signature motif; other site 469383002008 Walker B; other site 469383002009 D-loop; other site 469383002010 H-loop/switch region; other site 469383002011 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 469383002012 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383002013 Proline dehydrogenase; Region: Pro_dh; cl03282 469383002014 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383002015 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 469383002016 active site 469383002017 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383002018 homotrimer interaction site [polypeptide binding]; other site 469383002019 putative active site [active] 469383002020 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 469383002021 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383002022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383002023 catalytic residue [active] 469383002024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 469383002025 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 469383002026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383002027 catalytic residue [active] 469383002028 EamA-like transporter family; Region: EamA; pfam00892 469383002029 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 469383002030 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383002031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383002032 NAD(P) binding site [chemical binding]; other site 469383002033 active site 469383002034 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 469383002035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383002036 putative DNA binding site [nucleotide binding]; other site 469383002037 putative Zn2+ binding site [ion binding]; other site 469383002038 AsnC family; Region: AsnC_trans_reg; pfam01037 469383002039 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383002040 TPP-binding site [chemical binding]; other site 469383002041 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 469383002042 PYR/PP interface [polypeptide binding]; other site 469383002043 dimer interface [polypeptide binding]; other site 469383002044 TPP binding site [chemical binding]; other site 469383002045 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383002046 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383002047 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383002048 E3 interaction surface; other site 469383002049 lipoyl attachment site [posttranslational modification]; other site 469383002050 e3 binding domain; Region: E3_binding; pfam02817 469383002051 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383002052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383002053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383002054 active site 469383002055 phosphorylation site [posttranslational modification] 469383002056 intermolecular recognition site; other site 469383002057 dimerization interface [polypeptide binding]; other site 469383002058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383002059 DNA binding residues [nucleotide binding] 469383002060 dimerization interface [polypeptide binding]; other site 469383002061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383002062 Histidine kinase; Region: HisKA_3; pfam07730 469383002063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383002064 ATP binding site [chemical binding]; other site 469383002065 Mg2+ binding site [ion binding]; other site 469383002066 G-X-G motif; other site 469383002067 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383002068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383002069 salt bridge; other site 469383002070 non-specific DNA binding site [nucleotide binding]; other site 469383002071 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383002072 sequence-specific DNA binding site [nucleotide binding]; other site 469383002073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383002074 non-specific DNA binding site [nucleotide binding]; other site 469383002075 salt bridge; other site 469383002076 sequence-specific DNA binding site [nucleotide binding]; other site 469383002077 RHS Repeat; Region: RHS_repeat; pfam05593 469383002078 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 469383002079 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 469383002080 Helix-turn-helix domain; Region: HTH_38; pfam13936 469383002081 Integrase core domain; Region: rve; pfam00665 469383002082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 469383002083 putative DNA binding site [nucleotide binding]; other site 469383002084 putative Zn2+ binding site [ion binding]; other site 469383002085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 469383002086 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 469383002087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383002088 non-specific DNA binding site [nucleotide binding]; other site 469383002089 salt bridge; other site 469383002090 sequence-specific DNA binding site [nucleotide binding]; other site 469383002091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383002092 dimerization interface [polypeptide binding]; other site 469383002093 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383002094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383002095 metal binding site [ion binding]; metal-binding site 469383002096 active site 469383002097 I-site; other site 469383002098 glutamate dehydrogenase; Region: PLN02477 469383002099 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383002100 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 469383002101 NAD(P) binding site [chemical binding]; other site 469383002102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469383002103 active site 469383002104 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 469383002105 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 469383002106 tetramer interface [polypeptide binding]; other site 469383002107 active site 469383002108 Mg2+/Mn2+ binding site [ion binding]; other site 469383002109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383002110 DNA-binding site [nucleotide binding]; DNA binding site 469383002111 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 469383002112 Permease; Region: Permease; pfam02405 469383002113 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383002114 Ligand Binding Site [chemical binding]; other site 469383002115 Amino acid permease; Region: AA_permease_2; pfam13520 469383002116 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 469383002117 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 469383002118 homodimer interface [polypeptide binding]; other site 469383002119 substrate-cofactor binding pocket; other site 469383002120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383002121 catalytic residue [active] 469383002122 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 469383002123 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 469383002124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383002125 Membrane transport protein; Region: Mem_trans; cl09117 469383002126 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 469383002127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383002128 dimer interface [polypeptide binding]; other site 469383002129 phosphorylation site [posttranslational modification] 469383002130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383002131 ATP binding site [chemical binding]; other site 469383002132 Mg2+ binding site [ion binding]; other site 469383002133 G-X-G motif; other site 469383002134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383002135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383002136 active site 469383002137 phosphorylation site [posttranslational modification] 469383002138 intermolecular recognition site; other site 469383002139 dimerization interface [polypeptide binding]; other site 469383002140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383002141 DNA binding site [nucleotide binding] 469383002142 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 469383002143 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 469383002144 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 469383002145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 469383002146 Soluble P-type ATPase [General function prediction only]; Region: COG4087 469383002147 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 469383002148 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 469383002149 Ligand Binding Site [chemical binding]; other site 469383002150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002151 Walker A/P-loop; other site 469383002152 ATP binding site [chemical binding]; other site 469383002153 Q-loop/lid; other site 469383002154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002155 ABC transporter signature motif; other site 469383002156 Walker B; other site 469383002157 D-loop; other site 469383002158 H-loop/switch region; other site 469383002159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002160 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 469383002161 Walker A/P-loop; other site 469383002162 ATP binding site [chemical binding]; other site 469383002163 Q-loop/lid; other site 469383002164 ABC transporter signature motif; other site 469383002165 Walker B; other site 469383002166 D-loop; other site 469383002167 H-loop/switch region; other site 469383002168 HTH domain; Region: HTH_11; pfam08279 469383002169 WYL domain; Region: WYL; pfam13280 469383002170 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 469383002171 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383002172 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 469383002173 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 469383002174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002175 Walker A/P-loop; other site 469383002176 ATP binding site [chemical binding]; other site 469383002177 Q-loop/lid; other site 469383002178 ABC transporter signature motif; other site 469383002179 Walker B; other site 469383002180 D-loop; other site 469383002181 H-loop/switch region; other site 469383002182 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 469383002183 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 469383002184 hypothetical protein; Provisional; Region: PRK00967 469383002185 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383002186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383002187 active site 469383002188 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383002189 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383002190 active site 469383002191 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 469383002192 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 469383002193 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 469383002194 lipoyl synthase; Provisional; Region: PRK05481 469383002195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383002196 FeS/SAM binding site; other site 469383002197 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 469383002198 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383002199 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383002200 E3 interaction surface; other site 469383002201 lipoyl attachment site [posttranslational modification]; other site 469383002202 e3 binding domain; Region: E3_binding; pfam02817 469383002203 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383002204 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383002205 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383002206 alpha subunit interface [polypeptide binding]; other site 469383002207 TPP binding site [chemical binding]; other site 469383002208 heterodimer interface [polypeptide binding]; other site 469383002209 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383002210 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 469383002211 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383002212 tetramer interface [polypeptide binding]; other site 469383002213 TPP-binding site [chemical binding]; other site 469383002214 heterodimer interface [polypeptide binding]; other site 469383002215 phosphorylation loop region [posttranslational modification] 469383002216 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 469383002217 active site clefts [active] 469383002218 zinc binding site [ion binding]; other site 469383002219 dimer interface [polypeptide binding]; other site 469383002220 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 469383002221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383002222 Coenzyme A binding pocket [chemical binding]; other site 469383002223 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 469383002224 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 469383002225 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383002226 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 469383002227 Domain of unknown function DUF87; Region: DUF87; pfam01935 469383002228 AAA-like domain; Region: AAA_10; pfam12846 469383002229 Short C-terminal domain; Region: SHOCT; pfam09851 469383002230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383002231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383002232 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 469383002233 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 469383002234 Ion channel; Region: Ion_trans_2; pfam07885 469383002235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383002237 putative substrate translocation pore; other site 469383002238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002239 putative substrate translocation pore; other site 469383002240 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 469383002241 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383002242 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383002243 DNA binding residues [nucleotide binding] 469383002244 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383002245 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383002246 E3 interaction surface; other site 469383002247 lipoyl attachment site [posttranslational modification]; other site 469383002248 e3 binding domain; Region: E3_binding; pfam02817 469383002249 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383002250 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383002251 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 469383002252 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 469383002253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383002254 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 469383002255 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 469383002256 active site 469383002257 thiamine phosphate binding site [chemical binding]; other site 469383002258 pyrophosphate binding site [ion binding]; other site 469383002259 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 469383002260 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 469383002261 hydroxyglutarate oxidase; Provisional; Region: PRK11728 469383002262 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 469383002263 thiS-thiF/thiG interaction site; other site 469383002264 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 469383002265 ThiS interaction site; other site 469383002266 putative active site [active] 469383002267 tetramer interface [polypeptide binding]; other site 469383002268 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 469383002269 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 469383002270 ornithine carbamoyltransferase; Provisional; Region: PRK00779 469383002271 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 469383002272 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 469383002273 Uncharacterized conserved protein [Function unknown]; Region: COG3791 469383002274 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 469383002275 active site 469383002276 Zn binding site [ion binding]; other site 469383002277 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 469383002278 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 469383002279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383002280 S-adenosylmethionine binding site [chemical binding]; other site 469383002281 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383002282 active site 469383002283 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 469383002284 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 469383002285 NAD(P) binding site [chemical binding]; other site 469383002286 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 469383002287 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 469383002288 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 469383002289 Fe-S cluster binding site [ion binding]; other site 469383002290 active site 469383002291 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383002292 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383002293 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 469383002294 PHP domain; Region: PHP; pfam02811 469383002295 active site 469383002296 PHP-associated; Region: PHP_C; pfam13263 469383002297 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 469383002298 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 469383002299 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 469383002300 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 469383002301 active site 469383002302 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 469383002303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383002304 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 469383002305 substrate binding site [chemical binding]; other site 469383002306 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383002307 ATP binding site [chemical binding]; other site 469383002308 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 469383002309 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 469383002310 minor groove reading motif; other site 469383002311 helix-hairpin-helix signature motif; other site 469383002312 substrate binding pocket [chemical binding]; other site 469383002313 active site 469383002314 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 469383002315 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 469383002316 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 469383002317 nucleotide binding site [chemical binding]; other site 469383002318 NEF interaction site [polypeptide binding]; other site 469383002319 SBD interface [polypeptide binding]; other site 469383002320 GrpE; Region: GrpE; pfam01025 469383002321 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 469383002322 dimer interface [polypeptide binding]; other site 469383002323 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 469383002324 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 469383002325 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 469383002326 HSP70 interaction site [polypeptide binding]; other site 469383002327 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 469383002328 Zn binding sites [ion binding]; other site 469383002329 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 469383002330 dimer interface [polypeptide binding]; other site 469383002331 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 469383002332 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383002333 DNA binding residues [nucleotide binding] 469383002334 putative dimer interface [polypeptide binding]; other site 469383002335 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 469383002336 Clp amino terminal domain; Region: Clp_N; pfam02861 469383002337 Clp amino terminal domain; Region: Clp_N; pfam02861 469383002338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383002339 Walker A motif; other site 469383002340 ATP binding site [chemical binding]; other site 469383002341 Walker B motif; other site 469383002342 arginine finger; other site 469383002343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383002344 Walker A motif; other site 469383002345 ATP binding site [chemical binding]; other site 469383002346 Walker B motif; other site 469383002347 arginine finger; other site 469383002348 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 469383002349 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383002350 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383002351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383002352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383002353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383002354 GYD domain; Region: GYD; pfam08734 469383002355 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 469383002356 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 469383002357 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383002358 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 469383002359 AIR carboxylase; Region: AIRC; pfam00731 469383002360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383002361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383002362 DNA binding site [nucleotide binding] 469383002363 domain linker motif; other site 469383002364 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383002365 acetylornithine deacetylase; Provisional; Region: PRK06837 469383002366 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383002367 metal binding site [ion binding]; metal-binding site 469383002368 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383002369 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383002370 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383002371 active site 469383002372 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 469383002373 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383002374 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 469383002375 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 469383002376 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 469383002377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383002378 putative PBP binding loops; other site 469383002379 dimer interface [polypeptide binding]; other site 469383002380 ABC-ATPase subunit interface; other site 469383002381 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383002382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383002383 dimer interface [polypeptide binding]; other site 469383002384 conserved gate region; other site 469383002385 putative PBP binding loops; other site 469383002386 ABC-ATPase subunit interface; other site 469383002387 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383002388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002389 Walker A/P-loop; other site 469383002390 ATP binding site [chemical binding]; other site 469383002391 Q-loop/lid; other site 469383002392 ABC transporter signature motif; other site 469383002393 Walker B; other site 469383002394 D-loop; other site 469383002395 H-loop/switch region; other site 469383002396 adenylosuccinate lyase; Provisional; Region: PRK07492 469383002397 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 469383002398 tetramer interface [polypeptide binding]; other site 469383002399 active site 469383002400 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 469383002401 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 469383002402 ATP binding site [chemical binding]; other site 469383002403 active site 469383002404 substrate binding site [chemical binding]; other site 469383002405 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 469383002406 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 469383002407 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 469383002408 putative active site [active] 469383002409 catalytic triad [active] 469383002410 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 469383002411 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 469383002412 dimerization interface [polypeptide binding]; other site 469383002413 ATP binding site [chemical binding]; other site 469383002414 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 469383002415 dimerization interface [polypeptide binding]; other site 469383002416 ATP binding site [chemical binding]; other site 469383002417 amidophosphoribosyltransferase; Region: purF; TIGR01134 469383002418 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 469383002419 active site 469383002420 tetramer interface [polypeptide binding]; other site 469383002421 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469383002422 active site 469383002423 DEAD-like helicases superfamily; Region: DEXDc; smart00487 469383002424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383002425 ATP binding site [chemical binding]; other site 469383002426 putative Mg++ binding site [ion binding]; other site 469383002427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383002428 nucleotide binding region [chemical binding]; other site 469383002429 ATP-binding site [chemical binding]; other site 469383002430 RQC domain; Region: RQC; pfam09382 469383002431 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 469383002432 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 469383002433 active site 469383002434 substrate binding site [chemical binding]; other site 469383002435 cosubstrate binding site; other site 469383002436 catalytic site [active] 469383002437 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 469383002438 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 469383002439 purine monophosphate binding site [chemical binding]; other site 469383002440 dimer interface [polypeptide binding]; other site 469383002441 putative catalytic residues [active] 469383002442 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 469383002443 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 469383002444 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 469383002445 anti sigma factor interaction site; other site 469383002446 regulatory phosphorylation site [posttranslational modification]; other site 469383002447 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 469383002448 PAS domain S-box; Region: sensory_box; TIGR00229 469383002449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383002450 putative active site [active] 469383002451 heme pocket [chemical binding]; other site 469383002452 PAS domain S-box; Region: sensory_box; TIGR00229 469383002453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383002454 putative active site [active] 469383002455 heme pocket [chemical binding]; other site 469383002456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383002457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383002458 metal binding site [ion binding]; metal-binding site 469383002459 active site 469383002460 I-site; other site 469383002461 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383002462 MarR family; Region: MarR_2; pfam12802 469383002463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383002464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383002465 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383002466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383002467 NAD(P) binding site [chemical binding]; other site 469383002468 active site 469383002469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383002470 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 469383002471 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 469383002472 active site 469383002473 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 469383002474 Phosphotransferase enzyme family; Region: APH; pfam01636 469383002475 putative active site [active] 469383002476 putative substrate binding site [chemical binding]; other site 469383002477 ATP binding site [chemical binding]; other site 469383002478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383002479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383002480 Methyltransferase domain; Region: Methyltransf_11; pfam08241 469383002481 UMP phosphatase; Provisional; Region: PRK10444 469383002482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383002483 active site 469383002484 motif I; other site 469383002485 motif II; other site 469383002486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383002487 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383002488 MarR family; Region: MarR; pfam01047 469383002489 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 469383002490 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 469383002491 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383002492 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383002493 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383002494 Cytochrome P450; Region: p450; cl12078 469383002495 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 469383002496 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 469383002497 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 469383002498 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383002499 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 469383002500 hypothetical protein; Provisional; Region: PRK02237 469383002501 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 469383002502 Cadmium resistance transporter; Region: Cad; pfam03596 469383002503 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 469383002504 conserved repeat domain; Region: B_ant_repeat; TIGR01451 469383002505 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383002506 conserved repeat domain; Region: B_ant_repeat; TIGR01451 469383002507 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 469383002508 putative dimer interface [polypeptide binding]; other site 469383002509 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383002510 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 469383002511 Short C-terminal domain; Region: SHOCT; pfam09851 469383002512 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 469383002513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383002514 DNA binding residues [nucleotide binding] 469383002515 YCII-related domain; Region: YCII; cl00999 469383002516 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 469383002517 ligand binding site [chemical binding]; other site 469383002518 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 469383002519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383002520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383002521 DNA binding residues [nucleotide binding] 469383002522 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383002523 Domain of unknown function (DUF385); Region: DUF385; cl04387 469383002524 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383002525 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383002526 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383002527 putative hydrophobic ligand binding site [chemical binding]; other site 469383002528 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 469383002529 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383002530 dimerization interface [polypeptide binding]; other site 469383002531 putative DNA binding site [nucleotide binding]; other site 469383002532 putative Zn2+ binding site [ion binding]; other site 469383002533 Cupin; Region: Cupin_6; pfam12852 469383002534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383002535 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383002536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383002537 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 469383002538 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 469383002539 NADP binding site [chemical binding]; other site 469383002540 active site 469383002541 steroid binding site; other site 469383002542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383002543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383002544 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 469383002545 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383002546 intersubunit interface [polypeptide binding]; other site 469383002547 HTH domain; Region: HTH_11; pfam08279 469383002548 WYL domain; Region: WYL; cl14852 469383002549 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 469383002550 active site 469383002551 catalytic residues [active] 469383002552 metal binding site [ion binding]; metal-binding site 469383002553 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 469383002554 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 469383002555 Domain of unknown function (DUF389); Region: DUF389; cl00781 469383002556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002557 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383002558 putative substrate translocation pore; other site 469383002559 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 469383002560 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383002561 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383002562 Walker A/P-loop; other site 469383002563 ATP binding site [chemical binding]; other site 469383002564 Q-loop/lid; other site 469383002565 ABC transporter signature motif; other site 469383002566 Walker B; other site 469383002567 D-loop; other site 469383002568 H-loop/switch region; other site 469383002569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383002570 DNA-binding site [nucleotide binding]; DNA binding site 469383002571 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 469383002572 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 469383002573 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 469383002574 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 469383002575 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 469383002576 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469383002577 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383002578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002579 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 469383002580 Walker A/P-loop; other site 469383002581 ATP binding site [chemical binding]; other site 469383002582 Q-loop/lid; other site 469383002583 ABC transporter signature motif; other site 469383002584 Walker B; other site 469383002585 D-loop; other site 469383002586 H-loop/switch region; other site 469383002587 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 469383002588 active site 469383002589 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 469383002590 aromatic chitin/cellulose binding site residues [chemical binding]; other site 469383002591 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 469383002592 aromatic chitin/cellulose binding site residues [chemical binding]; other site 469383002593 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 469383002594 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 469383002595 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 469383002596 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 469383002597 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 469383002598 active site 469383002599 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 469383002600 CoenzymeA binding site [chemical binding]; other site 469383002601 subunit interaction site [polypeptide binding]; other site 469383002602 PHB binding site; other site 469383002603 Family description; Region: VCBS; pfam13517 469383002604 Family description; Region: VCBS; pfam13517 469383002605 Family description; Region: VCBS; pfam13517 469383002606 Family description; Region: VCBS; pfam13517 469383002607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383002608 dimerization interface [polypeptide binding]; other site 469383002609 putative DNA binding site [nucleotide binding]; other site 469383002610 putative Zn2+ binding site [ion binding]; other site 469383002611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002613 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 469383002614 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383002615 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383002616 Peptidase family M23; Region: Peptidase_M23; pfam01551 469383002617 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 469383002618 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 469383002619 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 469383002620 Predicted membrane protein [Function unknown]; Region: COG4325 469383002621 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 469383002622 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 469383002623 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 469383002624 Nitrogen regulatory protein P-II; Region: P-II; smart00938 469383002625 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 469383002626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383002627 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383002628 NAD(P) binding site [chemical binding]; other site 469383002629 active site 469383002630 Cupin; Region: Cupin_6; pfam12852 469383002631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383002632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383002633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383002634 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383002635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383002636 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 469383002637 putative metal binding site [ion binding]; other site 469383002638 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383002639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383002640 putative DNA binding site [nucleotide binding]; other site 469383002641 putative Zn2+ binding site [ion binding]; other site 469383002642 AsnC family; Region: AsnC_trans_reg; pfam01037 469383002643 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 469383002644 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 469383002645 dimer interface [polypeptide binding]; other site 469383002646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383002647 catalytic residue [active] 469383002648 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 469383002649 cystathionine gamma-synthase; Provisional; Region: PRK07811 469383002650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383002651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383002652 catalytic residue [active] 469383002653 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383002654 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 469383002655 isocitrate dehydrogenase; Validated; Region: PRK08299 469383002656 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 469383002657 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 469383002658 FAD binding pocket [chemical binding]; other site 469383002659 FAD binding motif [chemical binding]; other site 469383002660 phosphate binding motif [ion binding]; other site 469383002661 NAD binding pocket [chemical binding]; other site 469383002662 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383002664 dimer interface [polypeptide binding]; other site 469383002665 conserved gate region; other site 469383002666 putative PBP binding loops; other site 469383002667 ABC-ATPase subunit interface; other site 469383002668 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383002670 dimer interface [polypeptide binding]; other site 469383002671 conserved gate region; other site 469383002672 putative PBP binding loops; other site 469383002673 ABC-ATPase subunit interface; other site 469383002674 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 469383002675 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383002676 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383002677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002678 Walker A/P-loop; other site 469383002679 ATP binding site [chemical binding]; other site 469383002680 Q-loop/lid; other site 469383002681 ABC transporter signature motif; other site 469383002682 Walker B; other site 469383002683 D-loop; other site 469383002684 H-loop/switch region; other site 469383002685 TOBE domain; Region: TOBE_2; pfam08402 469383002686 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 469383002687 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383002688 dimer interface [polypeptide binding]; other site 469383002689 active site 469383002690 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383002691 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383002692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002693 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 469383002694 Walker A/P-loop; other site 469383002695 ATP binding site [chemical binding]; other site 469383002696 Q-loop/lid; other site 469383002697 ABC transporter signature motif; other site 469383002698 Walker B; other site 469383002699 D-loop; other site 469383002700 H-loop/switch region; other site 469383002701 Predicted transcriptional regulator [Transcription]; Region: COG2378 469383002702 HTH domain; Region: HTH_11; pfam08279 469383002703 WYL domain; Region: WYL; pfam13280 469383002704 Transcriptional regulator [Transcription]; Region: LytR; COG1316 469383002705 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 469383002706 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 469383002707 FAD binding pocket [chemical binding]; other site 469383002708 FAD binding motif [chemical binding]; other site 469383002709 phosphate binding motif [ion binding]; other site 469383002710 beta-alpha-beta structure motif; other site 469383002711 NAD binding pocket [chemical binding]; other site 469383002712 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 469383002713 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 469383002714 Moco binding site; other site 469383002715 metal coordination site [ion binding]; other site 469383002716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383002717 protochlorophyllide reductase; Region: PLN00015 469383002718 NAD(P) binding site [chemical binding]; other site 469383002719 active site 469383002720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383002721 sequence-specific DNA binding site [nucleotide binding]; other site 469383002722 salt bridge; other site 469383002723 Cupin domain; Region: Cupin_2; pfam07883 469383002724 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383002725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383002726 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 469383002727 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383002728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383002729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383002730 dimer interface [polypeptide binding]; other site 469383002731 conserved gate region; other site 469383002732 putative PBP binding loops; other site 469383002733 ABC-ATPase subunit interface; other site 469383002734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383002735 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 469383002736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383002737 dimer interface [polypeptide binding]; other site 469383002738 conserved gate region; other site 469383002739 ABC-ATPase subunit interface; other site 469383002740 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383002741 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383002742 Walker A/P-loop; other site 469383002743 ATP binding site [chemical binding]; other site 469383002744 Q-loop/lid; other site 469383002745 ABC transporter signature motif; other site 469383002746 Walker B; other site 469383002747 D-loop; other site 469383002748 H-loop/switch region; other site 469383002749 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383002750 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383002751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383002752 Walker A/P-loop; other site 469383002753 ATP binding site [chemical binding]; other site 469383002754 Q-loop/lid; other site 469383002755 ABC transporter signature motif; other site 469383002756 Walker B; other site 469383002757 D-loop; other site 469383002758 H-loop/switch region; other site 469383002759 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383002760 PemK-like protein; Region: PemK; pfam02452 469383002761 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 469383002762 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 469383002763 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383002764 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383002765 catalytic residue [active] 469383002766 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 469383002767 homotrimer interaction site [polypeptide binding]; other site 469383002768 putative active site [active] 469383002769 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383002770 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 469383002771 active site 469383002772 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383002773 hypothetical protein; Provisional; Region: PRK06446 469383002774 metal binding site [ion binding]; metal-binding site 469383002775 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 469383002776 hydrophobic ligand binding site; other site 469383002777 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383002778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383002779 DNA-binding site [nucleotide binding]; DNA binding site 469383002780 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383002781 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 469383002782 amphipathic channel; other site 469383002783 Asn-Pro-Ala signature motifs; other site 469383002784 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383002785 Ligand Binding Site [chemical binding]; other site 469383002786 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383002787 Ligand Binding Site [chemical binding]; other site 469383002788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383002789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383002790 Coenzyme A binding pocket [chemical binding]; other site 469383002791 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 469383002792 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383002793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383002794 DNA-binding site [nucleotide binding]; DNA binding site 469383002795 FCD domain; Region: FCD; pfam07729 469383002796 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383002797 Cytochrome P450; Region: p450; cl12078 469383002798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002799 Walker A/P-loop; other site 469383002800 ATP binding site [chemical binding]; other site 469383002801 Q-loop/lid; other site 469383002802 ABC transporter signature motif; other site 469383002803 Walker B; other site 469383002804 D-loop; other site 469383002805 Predicted membrane protein [Function unknown]; Region: COG1511 469383002806 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 469383002807 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 469383002808 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 469383002809 active site 469383002810 dimer interface [polypeptide binding]; other site 469383002811 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 469383002812 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 469383002813 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 469383002814 ligand binding site [chemical binding]; other site 469383002815 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 469383002816 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 469383002817 active site 2 [active] 469383002818 active site 1 [active] 469383002819 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 469383002820 enoyl-CoA hydratase; Provisional; Region: PRK06563 469383002821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383002822 substrate binding site [chemical binding]; other site 469383002823 oxyanion hole (OAH) forming residues; other site 469383002824 trimer interface [polypeptide binding]; other site 469383002825 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 469383002826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383002827 active site 469383002828 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 469383002829 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 469383002830 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469383002831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383002832 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 469383002833 Coenzyme A binding pocket [chemical binding]; other site 469383002834 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383002835 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383002836 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383002837 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383002838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002839 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 469383002840 Walker A/P-loop; other site 469383002841 ATP binding site [chemical binding]; other site 469383002842 Q-loop/lid; other site 469383002843 ABC transporter signature motif; other site 469383002844 Walker B; other site 469383002845 D-loop; other site 469383002846 H-loop/switch region; other site 469383002847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383002848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383002849 DNA binding residues [nucleotide binding] 469383002850 dimerization interface [polypeptide binding]; other site 469383002851 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 469383002852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383002853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383002854 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383002855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002856 exopolyphosphatase; Region: exo_poly_only; TIGR03706 469383002857 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 469383002858 HD domain; Region: HD_4; pfam13328 469383002859 polyphosphate kinase; Provisional; Region: PRK05443 469383002860 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 469383002861 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 469383002862 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 469383002863 putative domain interface [polypeptide binding]; other site 469383002864 putative active site [active] 469383002865 catalytic site [active] 469383002866 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 469383002867 putative domain interface [polypeptide binding]; other site 469383002868 putative active site [active] 469383002869 catalytic site [active] 469383002870 CsbD-like; Region: CsbD; pfam05532 469383002871 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 469383002872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383002873 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469383002874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383002875 DNA binding residues [nucleotide binding] 469383002876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383002878 putative substrate translocation pore; other site 469383002879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383002880 Membrane protein of unknown function; Region: DUF360; pfam04020 469383002881 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 469383002882 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 469383002883 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 469383002884 hypothetical protein; Provisional; Region: PRK07208 469383002885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383002886 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 469383002887 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383002888 NAD(P) binding site [chemical binding]; other site 469383002889 catalytic residues [active] 469383002890 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469383002891 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383002892 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383002893 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383002894 active site 469383002895 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383002896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383002897 DNA-binding site [nucleotide binding]; DNA binding site 469383002898 FCD domain; Region: FCD; pfam07729 469383002899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383002900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383002901 DNA binding site [nucleotide binding] 469383002902 domain linker motif; other site 469383002903 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383002904 dimerization interface [polypeptide binding]; other site 469383002905 ligand binding site [chemical binding]; other site 469383002906 agmatinase; Region: agmatinase; TIGR01230 469383002907 Agmatinase-like family; Region: Agmatinase-like; cd09990 469383002908 active site 469383002909 oligomer interface [polypeptide binding]; other site 469383002910 Mn binding site [ion binding]; other site 469383002911 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 469383002912 Predicted amidohydrolase [General function prediction only]; Region: COG0388 469383002913 active site 469383002914 catalytic triad [active] 469383002915 dimer interface [polypeptide binding]; other site 469383002916 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 469383002917 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 469383002918 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383002919 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383002920 active site 469383002921 metal binding site [ion binding]; metal-binding site 469383002922 Cache domain; Region: Cache_1; pfam02743 469383002923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383002924 dimerization interface [polypeptide binding]; other site 469383002925 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 469383002926 dimerization interface [polypeptide binding]; other site 469383002927 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 469383002928 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383002929 dimer interface [polypeptide binding]; other site 469383002930 putative CheW interface [polypeptide binding]; other site 469383002931 aconitate hydratase; Validated; Region: PRK09277 469383002932 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 469383002933 substrate binding site [chemical binding]; other site 469383002934 ligand binding site [chemical binding]; other site 469383002935 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 469383002936 substrate binding site [chemical binding]; other site 469383002937 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 469383002938 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383002939 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383002940 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 469383002941 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 469383002942 oligomer interface [polypeptide binding]; other site 469383002943 active site 469383002944 metal binding site [ion binding]; metal-binding site 469383002945 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 469383002946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383002947 motif II; other site 469383002948 short chain dehydrogenase; Validated; Region: PRK06182 469383002949 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 469383002950 NADP binding site [chemical binding]; other site 469383002951 active site 469383002952 steroid binding site; other site 469383002953 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 469383002954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383002955 Walker A/P-loop; other site 469383002956 ATP binding site [chemical binding]; other site 469383002957 ABC transporter signature motif; other site 469383002958 Walker B; other site 469383002959 D-loop; other site 469383002960 H-loop/switch region; other site 469383002961 ABC transporter; Region: ABC_tran_2; pfam12848 469383002962 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469383002963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 469383002964 binding surface 469383002965 TPR repeat; Region: TPR_11; pfam13414 469383002966 TPR motif; other site 469383002967 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383002968 active site 469383002969 HIGH motif; other site 469383002970 nucleotide binding site [chemical binding]; other site 469383002971 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383002972 active site 469383002973 KMSKS motif; other site 469383002974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383002975 S-adenosylmethionine binding site [chemical binding]; other site 469383002976 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383002977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383002978 S-adenosylmethionine binding site [chemical binding]; other site 469383002979 hypothetical protein; Provisional; Region: PRK07206 469383002980 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 469383002981 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 469383002982 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383002983 AMP binding site [chemical binding]; other site 469383002984 active site 469383002985 acyl-activating enzyme (AAE) consensus motif; other site 469383002986 CoA binding site [chemical binding]; other site 469383002987 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 469383002988 Fic family protein [Function unknown]; Region: COG3177 469383002989 Fic/DOC family; Region: Fic; pfam02661 469383002990 hypothetical protein; Provisional; Region: PRK03298 469383002991 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383002992 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 469383002993 active site pocket [active] 469383002994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383002995 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383002996 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383002997 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383002998 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383002999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383003000 dimer interface [polypeptide binding]; other site 469383003001 conserved gate region; other site 469383003002 putative PBP binding loops; other site 469383003003 ABC-ATPase subunit interface; other site 469383003004 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383003005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383003006 dimer interface [polypeptide binding]; other site 469383003007 conserved gate region; other site 469383003008 putative PBP binding loops; other site 469383003009 ABC-ATPase subunit interface; other site 469383003010 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383003011 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383003012 Walker A/P-loop; other site 469383003013 ATP binding site [chemical binding]; other site 469383003014 Q-loop/lid; other site 469383003015 ABC transporter signature motif; other site 469383003016 Walker B; other site 469383003017 D-loop; other site 469383003018 H-loop/switch region; other site 469383003019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383003020 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 469383003021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383003022 Walker A/P-loop; other site 469383003023 ATP binding site [chemical binding]; other site 469383003024 Q-loop/lid; other site 469383003025 ABC transporter signature motif; other site 469383003026 Walker B; other site 469383003027 D-loop; other site 469383003028 H-loop/switch region; other site 469383003029 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383003030 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383003031 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383003032 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383003033 classical (c) SDRs; Region: SDR_c; cd05233 469383003034 NAD(P) binding site [chemical binding]; other site 469383003035 active site 469383003036 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 469383003037 SxDxEG motif; other site 469383003038 active site 469383003039 metal binding site [ion binding]; metal-binding site 469383003040 homopentamer interface [polypeptide binding]; other site 469383003041 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383003042 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383003043 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383003044 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 469383003045 active site pocket [active] 469383003046 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 469383003047 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 469383003048 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383003049 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383003050 active site 469383003051 metal binding site [ion binding]; metal-binding site 469383003052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383003053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383003054 DNA binding site [nucleotide binding] 469383003055 domain linker motif; other site 469383003056 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383003057 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383003058 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383003059 Domain of unknown function (DUF718); Region: DUF718; cl01281 469383003060 alanine racemase; Reviewed; Region: alr; PRK00053 469383003061 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 469383003062 active site 469383003063 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383003064 dimer interface [polypeptide binding]; other site 469383003065 substrate binding site [chemical binding]; other site 469383003066 catalytic residues [active] 469383003067 Predicted acyl esterases [General function prediction only]; Region: COG2936 469383003068 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383003069 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 469383003070 Amidohydrolase; Region: Amidohydro_2; pfam04909 469383003071 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 469383003072 tartrate dehydrogenase; Region: TTC; TIGR02089 469383003073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383003074 NAD(P) binding site [chemical binding]; other site 469383003075 active site 469383003076 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 469383003077 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383003078 tetramer interface [polypeptide binding]; other site 469383003079 TPP-binding site [chemical binding]; other site 469383003080 heterodimer interface [polypeptide binding]; other site 469383003081 phosphorylation loop region [posttranslational modification] 469383003082 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383003083 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383003084 alpha subunit interface [polypeptide binding]; other site 469383003085 TPP binding site [chemical binding]; other site 469383003086 heterodimer interface [polypeptide binding]; other site 469383003087 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383003088 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 469383003089 Winged helix-turn helix; Region: HTH_29; pfam13551 469383003090 Integrase core domain; Region: rve; pfam00665 469383003091 Integrase core domain; Region: rve_3; pfam13683 469383003092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383003093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383003094 DNA binding residues [nucleotide binding] 469383003095 dimerization interface [polypeptide binding]; other site 469383003096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383003098 putative substrate translocation pore; other site 469383003099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003100 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 469383003101 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 469383003102 active site 469383003103 DNA binding site [nucleotide binding] 469383003104 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 469383003105 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383003106 E3 interaction surface; other site 469383003107 lipoyl attachment site [posttranslational modification]; other site 469383003108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383003109 E3 interaction surface; other site 469383003110 lipoyl attachment site [posttranslational modification]; other site 469383003111 e3 binding domain; Region: E3_binding; pfam02817 469383003112 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 469383003113 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383003114 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383003115 TPP-binding site [chemical binding]; other site 469383003116 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 469383003117 dimer interface [polypeptide binding]; other site 469383003118 PYR/PP interface [polypeptide binding]; other site 469383003119 TPP binding site [chemical binding]; other site 469383003120 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 469383003121 nudix motif; other site 469383003122 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383003123 FAD binding domain; Region: FAD_binding_4; pfam01565 469383003124 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 469383003125 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 469383003126 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 469383003127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383003128 putative DNA binding site [nucleotide binding]; other site 469383003129 dimerization interface [polypeptide binding]; other site 469383003130 putative Zn2+ binding site [ion binding]; other site 469383003131 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 469383003132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383003133 dimer interface [polypeptide binding]; other site 469383003134 active site 469383003135 metal binding site [ion binding]; metal-binding site 469383003136 glutathione binding site [chemical binding]; other site 469383003137 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 469383003138 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 469383003139 ABC1 family; Region: ABC1; pfam03109 469383003140 serine/threonine protein kinase; Provisional; Region: PRK14879 469383003141 Uncharacterized conserved protein [Function unknown]; Region: COG0398 469383003142 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 469383003143 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469383003144 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 469383003145 putative active site [active] 469383003146 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 469383003147 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 469383003148 domain interfaces; other site 469383003149 active site 469383003150 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383003151 guanine deaminase; Region: guan_deamin; TIGR02967 469383003152 active site 469383003153 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383003154 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 469383003155 NAD(P) binding site [chemical binding]; other site 469383003156 catalytic residues [active] 469383003157 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383003158 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383003159 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383003160 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 469383003161 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383003162 active site 469383003163 Isochorismatase family; Region: Isochorismatase; pfam00857 469383003164 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 469383003165 catalytic triad [active] 469383003166 conserved cis-peptide bond; other site 469383003167 Amino acid synthesis; Region: AA_synth; pfam06684 469383003168 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 469383003169 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 469383003170 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 469383003171 active site 469383003172 Zn2+ binding site [ion binding]; other site 469383003173 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 469383003174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383003175 O-methyltransferase; Region: Methyltransf_2; pfam00891 469383003176 short chain dehydrogenase; Provisional; Region: PRK06197 469383003177 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 469383003178 putative NAD(P) binding site [chemical binding]; other site 469383003179 active site 469383003180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383003181 Uncharacterized conserved protein [Function unknown]; Region: COG3391 469383003182 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 469383003183 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 469383003184 putative catalytic site [active] 469383003185 putative phosphate binding site [ion binding]; other site 469383003186 active site 469383003187 metal binding site A [ion binding]; metal-binding site 469383003188 DNA binding site [nucleotide binding] 469383003189 putative AP binding site [nucleotide binding]; other site 469383003190 putative metal binding site B [ion binding]; other site 469383003191 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383003192 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 469383003193 Protein of unknown function (DUF2419); Region: DUF2419; pfam10343 469383003194 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 469383003195 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 469383003196 DNA binding site [nucleotide binding] 469383003197 active site 469383003198 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 469383003199 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 469383003200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383003201 AlkA N-terminal domain; Region: AlkA_N; pfam06029 469383003202 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 469383003203 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 469383003204 helix-hairpin-helix signature motif; other site 469383003205 substrate binding pocket [chemical binding]; other site 469383003206 active site 469383003207 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 469383003208 Ligand Binding Site [chemical binding]; other site 469383003209 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 469383003210 dimer interface [polypeptide binding]; other site 469383003211 Alkaline phosphatase homologues; Region: alkPPc; smart00098 469383003212 active site 469383003213 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 469383003214 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 469383003215 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383003216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383003217 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383003218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 469383003219 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 469383003220 FAD binding site [chemical binding]; other site 469383003221 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 469383003222 Lipase (class 2); Region: Lipase_2; pfam01674 469383003223 Protein of unknown function DUF45; Region: DUF45; pfam01863 469383003224 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 469383003225 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383003226 substrate binding site [chemical binding]; other site 469383003227 ATP binding site [chemical binding]; other site 469383003228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383003229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383003230 Coenzyme A binding pocket [chemical binding]; other site 469383003231 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 469383003232 Citrate synthase; Region: Citrate_synt; pfam00285 469383003233 oxalacetate binding site [chemical binding]; other site 469383003234 citrylCoA binding site [chemical binding]; other site 469383003235 coenzyme A binding site [chemical binding]; other site 469383003236 catalytic triad [active] 469383003237 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 469383003238 trimer interface [polypeptide binding]; other site 469383003239 active site 469383003240 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383003241 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 469383003242 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383003243 substrate binding site [chemical binding]; other site 469383003244 ATP binding site [chemical binding]; other site 469383003245 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383003246 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 469383003247 NAD(P) binding site [chemical binding]; other site 469383003248 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 469383003249 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 469383003250 ATP binding site [chemical binding]; other site 469383003251 Mg++ binding site [ion binding]; other site 469383003252 motif III; other site 469383003253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383003254 nucleotide binding region [chemical binding]; other site 469383003255 ATP-binding site [chemical binding]; other site 469383003256 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 469383003257 RNA binding site [nucleotide binding]; other site 469383003258 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 469383003259 nudix motif; other site 469383003260 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 469383003261 active site 469383003262 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 469383003263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 469383003264 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469383003265 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 469383003266 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 469383003267 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 469383003268 NAD(P) binding site [chemical binding]; other site 469383003269 catalytic residues [active] 469383003270 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 469383003271 Phosphotransferase enzyme family; Region: APH; pfam01636 469383003272 putative active site [active] 469383003273 putative substrate binding site [chemical binding]; other site 469383003274 ATP binding site [chemical binding]; other site 469383003275 Stress up-regulated Nod 19; Region: SURNod19; pfam07712 469383003276 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 469383003277 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 469383003278 putative DNA binding site [nucleotide binding]; other site 469383003279 catalytic residue [active] 469383003280 putative H2TH interface [polypeptide binding]; other site 469383003281 putative catalytic residues [active] 469383003282 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 469383003283 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 469383003284 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 469383003285 catalytic triad [active] 469383003286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383003287 putative DNA binding site [nucleotide binding]; other site 469383003288 putative Zn2+ binding site [ion binding]; other site 469383003289 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383003290 putative hydrophobic ligand binding site [chemical binding]; other site 469383003291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383003292 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 469383003293 active site 469383003294 catalytic triad [active] 469383003295 oxyanion hole [active] 469383003296 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 469383003297 Bacterial transcriptional activator domain; Region: BTAD; smart01043 469383003298 AAA ATPase domain; Region: AAA_16; pfam13191 469383003299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 469383003300 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 469383003301 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383003302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383003303 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 469383003304 Walker A/P-loop; other site 469383003305 ATP binding site [chemical binding]; other site 469383003306 Q-loop/lid; other site 469383003307 ABC transporter signature motif; other site 469383003308 Walker B; other site 469383003309 D-loop; other site 469383003310 H-loop/switch region; other site 469383003311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003312 putative substrate translocation pore; other site 469383003313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383003315 AAA ATPase domain; Region: AAA_16; pfam13191 469383003316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383003317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383003318 DNA binding residues [nucleotide binding] 469383003319 dimerization interface [polypeptide binding]; other site 469383003320 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 469383003321 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 469383003322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383003323 SCP-2 sterol transfer family; Region: SCP2; pfam02036 469383003324 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 469383003325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383003326 Coenzyme A binding pocket [chemical binding]; other site 469383003327 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 469383003328 Winged helix-turn helix; Region: HTH_29; pfam13551 469383003329 Integrase core domain; Region: rve; pfam00665 469383003330 Integrase core domain; Region: rve_3; pfam13683 469383003331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383003332 NAD(P) binding site [chemical binding]; other site 469383003333 active site 469383003334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383003335 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 469383003336 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 469383003337 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 469383003338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383003339 catalytic residue [active] 469383003340 acetyl-CoA synthetase; Provisional; Region: PRK00174 469383003341 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 469383003342 active site 469383003343 CoA binding site [chemical binding]; other site 469383003344 acyl-activating enzyme (AAE) consensus motif; other site 469383003345 AMP binding site [chemical binding]; other site 469383003346 acetate binding site [chemical binding]; other site 469383003347 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 469383003348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383003349 acyl-activating enzyme (AAE) consensus motif; other site 469383003350 AMP binding site [chemical binding]; other site 469383003351 active site 469383003352 CoA binding site [chemical binding]; other site 469383003353 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 469383003354 Thymidylate synthase complementing protein; Region: Thy1; cl03630 469383003355 Thymidylate synthase complementing protein; Region: Thy1; cl03630 469383003356 seryl-tRNA synthetase; Provisional; Region: PRK05431 469383003357 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 469383003358 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 469383003359 dimer interface [polypeptide binding]; other site 469383003360 active site 469383003361 motif 1; other site 469383003362 motif 2; other site 469383003363 motif 3; other site 469383003364 CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; Region: cdhA; TIGR00314 469383003365 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 469383003366 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 469383003367 NADH dehydrogenase subunit B; Validated; Region: PRK06411 469383003368 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 469383003369 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 469383003370 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 469383003371 NADH dehydrogenase subunit D; Validated; Region: PRK06075 469383003372 NADH dehydrogenase subunit E; Validated; Region: PRK07539 469383003373 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 469383003374 putative dimer interface [polypeptide binding]; other site 469383003375 [2Fe-2S] cluster binding site [ion binding]; other site 469383003376 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 469383003377 SLBB domain; Region: SLBB; pfam10531 469383003378 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 469383003379 NADH dehydrogenase subunit G; Validated; Region: PRK09129 469383003380 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383003381 catalytic loop [active] 469383003382 iron binding site [ion binding]; other site 469383003383 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 469383003384 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383003385 molybdopterin cofactor binding site; other site 469383003386 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383003387 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 469383003388 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 469383003389 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 469383003390 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 469383003391 4Fe-4S binding domain; Region: Fer4; pfam00037 469383003392 4Fe-4S binding domain; Region: Fer4; pfam00037 469383003393 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 469383003394 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 469383003395 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 469383003396 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469383003397 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 469383003398 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469383003399 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 469383003400 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469383003401 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383003402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383003403 DNA-binding site [nucleotide binding]; DNA binding site 469383003404 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 469383003405 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 469383003406 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 469383003407 Predicted transcriptional regulator [Transcription]; Region: COG2345 469383003408 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 469383003409 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 469383003410 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 469383003411 Ferredoxin [Energy production and conversion]; Region: COG1146 469383003412 4Fe-4S binding domain; Region: Fer4; pfam00037 469383003413 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383003414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383003415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383003416 DNA binding residues [nucleotide binding] 469383003417 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 469383003418 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 469383003419 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 469383003420 homodimer interface [polypeptide binding]; other site 469383003421 substrate-cofactor binding pocket; other site 469383003422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383003423 catalytic residue [active] 469383003424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383003425 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 469383003426 Walker A/P-loop; other site 469383003427 ATP binding site [chemical binding]; other site 469383003428 Q-loop/lid; other site 469383003429 ABC transporter signature motif; other site 469383003430 Walker B; other site 469383003431 D-loop; other site 469383003432 H-loop/switch region; other site 469383003433 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 469383003434 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 469383003435 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 469383003436 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 469383003437 dimerization interface [polypeptide binding]; other site 469383003438 DPS ferroxidase diiron center [ion binding]; other site 469383003439 ion pore; other site 469383003440 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383003441 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 469383003442 substrate binding site [chemical binding]; other site 469383003443 dimer interface [polypeptide binding]; other site 469383003444 ATP binding site [chemical binding]; other site 469383003445 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383003446 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469383003447 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 469383003448 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 469383003449 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383003450 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 469383003451 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 469383003452 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 469383003453 active site 469383003454 catalytic site [active] 469383003455 substrate binding site [chemical binding]; other site 469383003456 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 469383003457 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 469383003458 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 469383003459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383003460 Walker A/P-loop; other site 469383003461 ATP binding site [chemical binding]; other site 469383003462 Q-loop/lid; other site 469383003463 ABC transporter signature motif; other site 469383003464 Walker B; other site 469383003465 D-loop; other site 469383003466 H-loop/switch region; other site 469383003467 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383003468 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383003469 Response regulator receiver domain; Region: Response_reg; pfam00072 469383003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383003471 active site 469383003472 phosphorylation site [posttranslational modification] 469383003473 intermolecular recognition site; other site 469383003474 dimerization interface [polypeptide binding]; other site 469383003475 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 469383003476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383003477 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469383003478 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469383003479 ligand binding site [chemical binding]; other site 469383003480 flexible hinge region; other site 469383003481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383003482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383003483 ATP binding site [chemical binding]; other site 469383003484 Mg2+ binding site [ion binding]; other site 469383003485 G-X-G motif; other site 469383003486 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383003487 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383003488 metal binding site [ion binding]; metal-binding site 469383003489 active site 469383003490 I-site; other site 469383003491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383003492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383003493 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 469383003494 putative dimerization interface [polypeptide binding]; other site 469383003495 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 469383003496 Class I aldolases; Region: Aldolase_Class_I; cl17187 469383003497 catalytic residue [active] 469383003498 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383003499 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383003500 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383003501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383003502 DNA-binding site [nucleotide binding]; DNA binding site 469383003503 FCD domain; Region: FCD; cl11656 469383003504 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 469383003505 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 469383003506 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 469383003507 putative deacylase active site [active] 469383003508 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469383003509 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 469383003510 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 469383003511 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 469383003512 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 469383003513 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 469383003514 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 469383003515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383003516 DNA-binding site [nucleotide binding]; DNA binding site 469383003517 PAS domain S-box; Region: sensory_box; TIGR00229 469383003518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383003519 putative active site [active] 469383003520 heme pocket [chemical binding]; other site 469383003521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383003522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383003523 metal binding site [ion binding]; metal-binding site 469383003524 active site 469383003525 I-site; other site 469383003526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383003527 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 469383003528 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 469383003529 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 469383003530 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383003531 MarR family; Region: MarR_2; pfam12802 469383003532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383003534 putative substrate translocation pore; other site 469383003535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383003536 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 469383003537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 469383003538 DNA-binding site [nucleotide binding]; DNA binding site 469383003539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383003540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383003541 homodimer interface [polypeptide binding]; other site 469383003542 catalytic residue [active] 469383003543 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 469383003544 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 469383003545 homodimer interface [polypeptide binding]; other site 469383003546 substrate-cofactor binding pocket; other site 469383003547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383003548 catalytic residue [active] 469383003549 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 469383003550 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383003551 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383003552 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 469383003553 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 469383003554 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 469383003555 FG-GAP repeat; Region: FG-GAP; cl15299 469383003556 FG-GAP repeat; Region: FG-GAP; cl15299 469383003557 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 469383003558 Htaa; Region: HtaA; pfam04213 469383003559 Helix-turn-helix domain; Region: HTH_18; pfam12833 469383003560 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 469383003561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383003562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 469383003563 catalytic core [active] 469383003564 Cupin domain; Region: Cupin_2; pfam07883 469383003565 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 469383003566 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 469383003567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383003568 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383003569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383003570 active site 469383003571 phosphorylation site [posttranslational modification] 469383003572 intermolecular recognition site; other site 469383003573 dimerization interface [polypeptide binding]; other site 469383003574 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383003575 DNA binding residues [nucleotide binding] 469383003576 dimerization interface [polypeptide binding]; other site 469383003577 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383003578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383003579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383003581 putative substrate translocation pore; other site 469383003582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383003584 MarR family; Region: MarR; pfam01047 469383003585 MarR family; Region: MarR_2; cl17246 469383003586 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383003587 Ligand Binding Site [chemical binding]; other site 469383003588 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383003589 Ligand Binding Site [chemical binding]; other site 469383003590 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 469383003591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383003592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383003593 DNA binding residues [nucleotide binding] 469383003594 dimerization interface [polypeptide binding]; other site 469383003595 MarR family; Region: MarR_2; cl17246 469383003596 PAS fold; Region: PAS; pfam00989 469383003597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383003598 putative active site [active] 469383003599 heme pocket [chemical binding]; other site 469383003600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383003601 PAS fold; Region: PAS_3; pfam08447 469383003602 putative active site [active] 469383003603 heme pocket [chemical binding]; other site 469383003604 PAS domain; Region: PAS_9; pfam13426 469383003605 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383003606 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383003607 metal binding site [ion binding]; metal-binding site 469383003608 active site 469383003609 I-site; other site 469383003610 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383003611 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 469383003612 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 469383003613 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383003614 inhibitor-cofactor binding pocket; inhibition site 469383003615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383003616 catalytic residue [active] 469383003617 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383003618 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383003619 NAD(P) binding site [chemical binding]; other site 469383003620 catalytic residues [active] 469383003621 Creatinine amidohydrolase; Region: Creatininase; pfam02633 469383003622 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383003623 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383003624 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383003625 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383003626 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383003627 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383003628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383003629 dimer interface [polypeptide binding]; other site 469383003630 conserved gate region; other site 469383003631 putative PBP binding loops; other site 469383003632 ABC-ATPase subunit interface; other site 469383003633 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383003634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383003635 dimer interface [polypeptide binding]; other site 469383003636 conserved gate region; other site 469383003637 putative PBP binding loops; other site 469383003638 ABC-ATPase subunit interface; other site 469383003639 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383003640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383003641 Walker A/P-loop; other site 469383003642 ATP binding site [chemical binding]; other site 469383003643 Q-loop/lid; other site 469383003644 ABC transporter signature motif; other site 469383003645 Walker B; other site 469383003646 D-loop; other site 469383003647 H-loop/switch region; other site 469383003648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383003649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383003650 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383003651 Walker A/P-loop; other site 469383003652 ATP binding site [chemical binding]; other site 469383003653 Q-loop/lid; other site 469383003654 ABC transporter signature motif; other site 469383003655 Walker B; other site 469383003656 D-loop; other site 469383003657 H-loop/switch region; other site 469383003658 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383003659 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383003660 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383003661 Family description; Region: VCBS; pfam13517 469383003662 Family description; Region: VCBS; pfam13517 469383003663 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 469383003664 Family description; Region: VCBS; pfam13517 469383003665 Family description; Region: VCBS; pfam13517 469383003666 Family description; Region: VCBS; pfam13517 469383003667 Family description; Region: VCBS; pfam13517 469383003668 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 469383003669 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 469383003670 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 469383003671 Uncharacterized conserved protein [Function unknown]; Region: COG5476 469383003672 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 469383003673 MlrC C-terminus; Region: MlrC_C; pfam07171 469383003674 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 469383003675 homotrimer interaction site [polypeptide binding]; other site 469383003676 putative active site [active] 469383003677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383003678 Transcriptional regulators [Transcription]; Region: MarR; COG1846 469383003679 putative DNA binding site [nucleotide binding]; other site 469383003680 dimerization interface [polypeptide binding]; other site 469383003681 putative Zn2+ binding site [ion binding]; other site 469383003682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383003683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 469383003684 nucleotide binding site [chemical binding]; other site 469383003685 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 469383003686 nucleotide binding site [chemical binding]; other site 469383003687 xylose isomerase; Provisional; Region: PRK12677 469383003688 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 469383003689 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383003690 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383003691 ligand binding site [chemical binding]; other site 469383003692 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383003693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383003694 Walker A/P-loop; other site 469383003695 ATP binding site [chemical binding]; other site 469383003696 Q-loop/lid; other site 469383003697 ABC transporter signature motif; other site 469383003698 Walker B; other site 469383003699 D-loop; other site 469383003700 H-loop/switch region; other site 469383003701 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383003702 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383003703 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383003704 TM-ABC transporter signature motif; other site 469383003705 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 469383003706 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 469383003707 substrate binding pocket [chemical binding]; other site 469383003708 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 469383003709 active site 469383003710 catalytic triad [active] 469383003711 oxyanion hole [active] 469383003712 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 469383003713 active site 469383003714 catalytic residues [active] 469383003715 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 469383003716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383003717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383003718 active site 469383003719 phosphorylation site [posttranslational modification] 469383003720 intermolecular recognition site; other site 469383003721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383003722 DNA binding residues [nucleotide binding] 469383003723 dimerization interface [polypeptide binding]; other site 469383003724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383003725 Histidine kinase; Region: HisKA_3; pfam07730 469383003726 MMPL family; Region: MMPL; pfam03176 469383003727 MMPL family; Region: MMPL; pfam03176 469383003728 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 469383003729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383003730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383003731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383003732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383003733 amidase; Provisional; Region: PRK06061 469383003734 Amidase; Region: Amidase; cl11426 469383003735 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383003736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383003737 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 469383003738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383003739 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383003740 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 469383003741 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383003742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383003743 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 469383003744 Coenzyme A binding pocket [chemical binding]; other site 469383003745 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469383003746 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383003747 active site 469383003748 metal binding site [ion binding]; metal-binding site 469383003749 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 469383003750 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 469383003751 Trp docking motif [polypeptide binding]; other site 469383003752 active site 469383003753 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 469383003754 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 469383003755 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 469383003756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383003757 DNA binding residues [nucleotide binding] 469383003758 VCBS repeat; Region: VCBS_repeat; TIGR01965 469383003759 VCBS repeat; Region: VCBS_repeat; TIGR01965 469383003760 VCBS repeat; Region: VCBS_repeat; TIGR01965 469383003761 VCBS repeat; Region: VCBS_repeat; TIGR01965 469383003762 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 469383003763 Phage Tail Collar Domain; Region: Collar; pfam07484 469383003764 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 469383003765 Phage Tail Collar Domain; Region: Collar; pfam07484 469383003766 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 469383003767 Phage Tail Collar Domain; Region: Collar; pfam07484 469383003768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 469383003769 GAF domain; Region: GAF; pfam01590 469383003770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383003771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383003772 ATP binding site [chemical binding]; other site 469383003773 Mg2+ binding site [ion binding]; other site 469383003774 G-X-G motif; other site 469383003775 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383003776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383003777 non-specific DNA binding site [nucleotide binding]; other site 469383003778 salt bridge; other site 469383003779 sequence-specific DNA binding site [nucleotide binding]; other site 469383003780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383003781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383003782 active site 469383003783 phosphorylation site [posttranslational modification] 469383003784 intermolecular recognition site; other site 469383003785 dimerization interface [polypeptide binding]; other site 469383003786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383003787 DNA binding residues [nucleotide binding] 469383003788 dimerization interface [polypeptide binding]; other site 469383003789 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 469383003790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383003791 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383003792 Beta-lactamase; Region: Beta-lactamase; cl17358 469383003793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383003794 putative active site [active] 469383003795 heme pocket [chemical binding]; other site 469383003796 PAS fold; Region: PAS_3; pfam08447 469383003797 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 469383003798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383003799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383003800 DNA binding residues [nucleotide binding] 469383003801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383003802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383003803 Coenzyme A binding pocket [chemical binding]; other site 469383003804 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 469383003805 CoA binding domain; Region: CoA_binding_2; pfam13380 469383003806 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 469383003807 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 469383003808 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383003809 Sulfatase; Region: Sulfatase; cl17466 469383003810 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383003811 Sulfatase; Region: Sulfatase; pfam00884 469383003812 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 469383003813 Low molecular weight phosphatase family; Region: LMWPc; cd00115 469383003814 active site 469383003815 Fructosamine kinase; Region: Fructosamin_kin; cl17579 469383003816 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 469383003817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383003818 S-adenosylmethionine binding site [chemical binding]; other site 469383003819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383003820 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 469383003821 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383003822 Protein export membrane protein; Region: SecD_SecF; cl14618 469383003823 MarR family; Region: MarR_2; pfam12802 469383003824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469383003825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469383003826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383003827 Walker A/P-loop; other site 469383003828 ATP binding site [chemical binding]; other site 469383003829 Q-loop/lid; other site 469383003830 ABC transporter signature motif; other site 469383003831 Walker B; other site 469383003832 D-loop; other site 469383003833 H-loop/switch region; other site 469383003834 KR domain; Region: KR; pfam08659 469383003835 extended (e) SDRs; Region: SDR_e; cd08946 469383003836 NAD(P) binding site [chemical binding]; other site 469383003837 active site 469383003838 substrate binding site [chemical binding]; other site 469383003839 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383003840 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383003841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383003842 DNA-binding site [nucleotide binding]; DNA binding site 469383003843 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383003844 FCD domain; Region: FCD; pfam07729 469383003845 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 469383003846 Predicted transcriptional regulator [Transcription]; Region: COG1959 469383003847 Transcriptional regulator; Region: Rrf2; pfam02082 469383003848 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 469383003849 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 469383003850 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 469383003851 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 469383003852 putative homodimer interface [polypeptide binding]; other site 469383003853 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 469383003854 heterodimer interface [polypeptide binding]; other site 469383003855 homodimer interface [polypeptide binding]; other site 469383003856 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 469383003857 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 469383003858 23S rRNA interface [nucleotide binding]; other site 469383003859 L7/L12 interface [polypeptide binding]; other site 469383003860 putative thiostrepton binding site; other site 469383003861 L25 interface [polypeptide binding]; other site 469383003862 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 469383003863 mRNA/rRNA interface [nucleotide binding]; other site 469383003864 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 469383003865 23S rRNA interface [nucleotide binding]; other site 469383003866 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 469383003867 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 469383003868 L11 interface [polypeptide binding]; other site 469383003869 putative EF-Tu interaction site [polypeptide binding]; other site 469383003870 putative EF-G interaction site [polypeptide binding]; other site 469383003871 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 469383003872 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 469383003873 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 469383003874 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 469383003875 RPB1 interaction site [polypeptide binding]; other site 469383003876 RPB10 interaction site [polypeptide binding]; other site 469383003877 RPB11 interaction site [polypeptide binding]; other site 469383003878 RPB3 interaction site [polypeptide binding]; other site 469383003879 RPB12 interaction site [polypeptide binding]; other site 469383003880 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 469383003881 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 469383003882 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 469383003883 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 469383003884 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 469383003885 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 469383003886 cleft; other site 469383003887 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 469383003888 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 469383003889 DNA binding site [nucleotide binding] 469383003890 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 469383003891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383003892 Coenzyme A binding pocket [chemical binding]; other site 469383003893 hypothetical protein; Provisional; Region: PRK06541 469383003894 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383003895 inhibitor-cofactor binding pocket; inhibition site 469383003896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383003897 catalytic residue [active] 469383003898 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383003899 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383003900 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 469383003901 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 469383003902 hexamer interface [polypeptide binding]; other site 469383003903 ligand binding site [chemical binding]; other site 469383003904 putative active site [active] 469383003905 NAD(P) binding site [chemical binding]; other site 469383003906 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 469383003907 S17 interaction site [polypeptide binding]; other site 469383003908 S8 interaction site; other site 469383003909 16S rRNA interaction site [nucleotide binding]; other site 469383003910 streptomycin interaction site [chemical binding]; other site 469383003911 23S rRNA interaction site [nucleotide binding]; other site 469383003912 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 469383003913 30S ribosomal protein S7; Validated; Region: PRK05302 469383003914 elongation factor G; Reviewed; Region: PRK00007 469383003915 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 469383003916 G1 box; other site 469383003917 putative GEF interaction site [polypeptide binding]; other site 469383003918 GTP/Mg2+ binding site [chemical binding]; other site 469383003919 Switch I region; other site 469383003920 G2 box; other site 469383003921 G3 box; other site 469383003922 Switch II region; other site 469383003923 G4 box; other site 469383003924 G5 box; other site 469383003925 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 469383003926 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 469383003927 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 469383003928 elongation factor Tu; Reviewed; Region: PRK00049 469383003929 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 469383003930 G1 box; other site 469383003931 GEF interaction site [polypeptide binding]; other site 469383003932 GTP/Mg2+ binding site [chemical binding]; other site 469383003933 Switch I region; other site 469383003934 G2 box; other site 469383003935 G3 box; other site 469383003936 Switch II region; other site 469383003937 G4 box; other site 469383003938 G5 box; other site 469383003939 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 469383003940 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 469383003941 Antibiotic Binding Site [chemical binding]; other site 469383003942 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 469383003943 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 469383003944 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 469383003945 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 469383003946 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 469383003947 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 469383003948 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 469383003949 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 469383003950 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 469383003951 putative translocon binding site; other site 469383003952 protein-rRNA interface [nucleotide binding]; other site 469383003953 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 469383003954 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 469383003955 G-X-X-G motif; other site 469383003956 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 469383003957 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 469383003958 23S rRNA interface [nucleotide binding]; other site 469383003959 5S rRNA interface [nucleotide binding]; other site 469383003960 putative antibiotic binding site [chemical binding]; other site 469383003961 L25 interface [polypeptide binding]; other site 469383003962 L27 interface [polypeptide binding]; other site 469383003963 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 469383003964 23S rRNA interface [nucleotide binding]; other site 469383003965 putative translocon interaction site; other site 469383003966 signal recognition particle (SRP54) interaction site; other site 469383003967 L23 interface [polypeptide binding]; other site 469383003968 trigger factor interaction site; other site 469383003969 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 469383003970 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 469383003971 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 469383003972 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 469383003973 RNA binding site [nucleotide binding]; other site 469383003974 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 469383003975 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 469383003976 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 469383003977 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 469383003978 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 469383003979 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 469383003980 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 469383003981 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 469383003982 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 469383003983 5S rRNA interface [nucleotide binding]; other site 469383003984 L5 interface [polypeptide binding]; other site 469383003985 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 469383003986 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 469383003987 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 469383003988 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 469383003989 23S rRNA binding site [nucleotide binding]; other site 469383003990 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 469383003991 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 469383003992 SecY translocase; Region: SecY; pfam00344 469383003993 adenylate kinase; Reviewed; Region: adk; PRK00279 469383003994 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 469383003995 AMP-binding site [chemical binding]; other site 469383003996 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 469383003997 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 469383003998 active site 469383003999 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 469383004000 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 469383004001 30S ribosomal protein S13; Region: bact_S13; TIGR03631 469383004002 30S ribosomal protein S11; Validated; Region: PRK05309 469383004003 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 469383004004 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 469383004005 alphaNTD - beta interaction site [polypeptide binding]; other site 469383004006 alphaNTD homodimer interface [polypeptide binding]; other site 469383004007 alphaNTD - beta' interaction site [polypeptide binding]; other site 469383004008 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 469383004009 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 469383004010 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 469383004011 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 469383004012 dimerization interface 3.5A [polypeptide binding]; other site 469383004013 active site 469383004014 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 469383004015 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 469383004016 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 469383004017 nucleotide binding pocket [chemical binding]; other site 469383004018 K-X-D-G motif; other site 469383004019 catalytic site [active] 469383004020 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 469383004021 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 469383004022 Dimer interface [polypeptide binding]; other site 469383004023 BRCT sequence motif; other site 469383004024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383004025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383004026 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 469383004027 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383004028 DNA binding residues [nucleotide binding] 469383004029 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 469383004030 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 469383004031 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 469383004032 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 469383004033 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 469383004034 DXD motif; other site 469383004035 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 469383004036 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 469383004037 glutaminase active site [active] 469383004038 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469383004039 dimer interface [polypeptide binding]; other site 469383004040 active site 469383004041 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 469383004042 dimer interface [polypeptide binding]; other site 469383004043 active site 469383004044 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 469383004045 Interdomain contacts; other site 469383004046 Cytokine receptor motif; other site 469383004047 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 469383004048 Interdomain contacts; other site 469383004049 Cytokine receptor motif; other site 469383004050 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 469383004051 active site 469383004052 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 469383004053 active site 469383004054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383004055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383004056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469383004057 dimerization interface [polypeptide binding]; other site 469383004058 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 469383004059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383004060 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 469383004061 putative dimerization interface [polypeptide binding]; other site 469383004062 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 469383004063 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 469383004064 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 469383004065 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 469383004066 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 469383004067 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 469383004068 Patatin-like phospholipase; Region: Patatin; pfam01734 469383004069 active site 469383004070 nucleophile elbow; other site 469383004071 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 469383004072 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 469383004073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383004074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383004075 homodimer interface [polypeptide binding]; other site 469383004076 catalytic residue [active] 469383004077 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 469383004078 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 469383004079 acyl-activating enzyme (AAE) consensus motif; other site 469383004080 putative AMP binding site [chemical binding]; other site 469383004081 putative active site [active] 469383004082 putative CoA binding site [chemical binding]; other site 469383004083 Uncharacterized conserved protein [Function unknown]; Region: COG0327 469383004084 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 469383004085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383004086 non-specific DNA binding site [nucleotide binding]; other site 469383004087 salt bridge; other site 469383004088 sequence-specific DNA binding site [nucleotide binding]; other site 469383004089 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 469383004090 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 469383004091 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 469383004092 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 469383004093 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 469383004094 putative di-iron ligands [ion binding]; other site 469383004095 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 469383004096 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 469383004097 FAD binding pocket [chemical binding]; other site 469383004098 FAD binding motif [chemical binding]; other site 469383004099 phosphate binding motif [ion binding]; other site 469383004100 beta-alpha-beta structure motif; other site 469383004101 NAD binding pocket [chemical binding]; other site 469383004102 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383004103 catalytic loop [active] 469383004104 iron binding site [ion binding]; other site 469383004105 Lamin Tail Domain; Region: LTD; pfam00932 469383004106 Lamin Tail Domain; Region: LTD; pfam00932 469383004107 Lamin Tail Domain; Region: LTD; pfam00932 469383004108 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 469383004109 RibD C-terminal domain; Region: RibD_C; cl17279 469383004110 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 469383004111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 469383004112 RibD C-terminal domain; Region: RibD_C; cl17279 469383004113 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 469383004114 short chain dehydrogenase; Provisional; Region: PRK06500 469383004115 classical (c) SDRs; Region: SDR_c; cd05233 469383004116 NAD(P) binding site [chemical binding]; other site 469383004117 active site 469383004118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383004119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383004120 LysR substrate binding domain; Region: LysR_substrate; pfam03466 469383004121 dimerization interface [polypeptide binding]; other site 469383004122 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383004123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383004124 DNA-binding site [nucleotide binding]; DNA binding site 469383004125 FCD domain; Region: FCD; pfam07729 469383004126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383004127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383004128 dimerization interface [polypeptide binding]; other site 469383004129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383004130 dimer interface [polypeptide binding]; other site 469383004131 phosphorylation site [posttranslational modification] 469383004132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383004133 ATP binding site [chemical binding]; other site 469383004134 Mg2+ binding site [ion binding]; other site 469383004135 G-X-G motif; other site 469383004136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383004137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383004138 active site 469383004139 phosphorylation site [posttranslational modification] 469383004140 intermolecular recognition site; other site 469383004141 dimerization interface [polypeptide binding]; other site 469383004142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383004143 DNA binding site [nucleotide binding] 469383004144 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 469383004145 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 469383004146 NAD binding site [chemical binding]; other site 469383004147 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 469383004148 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 469383004149 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 469383004150 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 469383004151 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 469383004152 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 469383004153 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469383004154 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469383004155 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 469383004156 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 469383004157 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 469383004158 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383004159 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 469383004160 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 469383004161 NAD binding site [chemical binding]; other site 469383004162 catalytic residues [active] 469383004163 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383004164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383004165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383004166 WHG domain; Region: WHG; pfam13305 469383004167 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 469383004168 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 469383004169 acyl-activating enzyme (AAE) consensus motif; other site 469383004170 putative AMP binding site [chemical binding]; other site 469383004171 putative active site [active] 469383004172 putative CoA binding site [chemical binding]; other site 469383004173 AAA ATPase domain; Region: AAA_16; pfam13191 469383004174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004176 DNA binding residues [nucleotide binding] 469383004177 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 469383004178 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 469383004179 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383004180 homotrimer interaction site [polypeptide binding]; other site 469383004181 putative active site [active] 469383004182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004184 DNA binding residues [nucleotide binding] 469383004185 dimerization interface [polypeptide binding]; other site 469383004186 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383004187 acyl-activating enzyme (AAE) consensus motif; other site 469383004188 AMP binding site [chemical binding]; other site 469383004189 active site 469383004190 CoA binding site [chemical binding]; other site 469383004191 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 469383004192 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 469383004193 Walker A motif; other site 469383004194 ATP binding site [chemical binding]; other site 469383004195 Walker B motif; other site 469383004196 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383004197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383004198 DNA binding residues [nucleotide binding] 469383004199 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 469383004200 AAA-like domain; Region: AAA_10; pfam12846 469383004201 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 469383004202 N-acetyl-D-glucosamine binding site [chemical binding]; other site 469383004203 catalytic residue [active] 469383004204 NlpC/P60 family; Region: NLPC_P60; cl17555 469383004205 AAA-like domain; Region: AAA_10; pfam12846 469383004206 Transposase, Mutator family; Region: Transposase_mut; pfam00872 469383004207 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383004208 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383004209 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383004210 active site 469383004211 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 469383004212 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 469383004213 intersubunit interface [polypeptide binding]; other site 469383004214 active site 469383004215 zinc binding site [ion binding]; other site 469383004216 Na+ binding site [ion binding]; other site 469383004217 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 469383004218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383004219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004220 NAD(P) binding site [chemical binding]; other site 469383004221 active site 469383004222 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 469383004223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383004224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383004225 catalytic residue [active] 469383004226 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383004227 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383004228 TM-ABC transporter signature motif; other site 469383004229 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383004230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383004231 Walker A/P-loop; other site 469383004232 ATP binding site [chemical binding]; other site 469383004233 Q-loop/lid; other site 469383004234 ABC transporter signature motif; other site 469383004235 Walker B; other site 469383004236 D-loop; other site 469383004237 H-loop/switch region; other site 469383004238 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383004239 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383004240 ligand binding site [chemical binding]; other site 469383004241 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383004242 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383004243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383004244 DNA-binding site [nucleotide binding]; DNA binding site 469383004245 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383004246 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 469383004247 active site 469383004248 NAD binding site [chemical binding]; other site 469383004249 metal binding site [ion binding]; metal-binding site 469383004250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383004251 Coenzyme A binding pocket [chemical binding]; other site 469383004252 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 469383004253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383004254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383004255 catalytic residue [active] 469383004256 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 469383004257 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 469383004258 AAA domain; Region: AAA_30; pfam13604 469383004259 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 469383004260 Kelch motif; Region: Kelch_1; pfam01344 469383004261 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 469383004262 Kelch domain; Region: Kelch; smart00612 469383004263 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 469383004264 Kelch domain; Region: Kelch; smart00612 469383004265 Kelch motif; Region: Kelch_6; pfam13964 469383004266 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 469383004267 Kelch domain; Region: Kelch; smart00612 469383004268 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 469383004269 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 469383004270 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383004271 extended (e) SDRs; Region: SDR_e; cd08946 469383004272 NAD(P) binding site [chemical binding]; other site 469383004273 active site 469383004274 substrate binding site [chemical binding]; other site 469383004275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383004276 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469383004277 active site 469383004278 catalytic tetrad [active] 469383004279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383004280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383004281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383004282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383004283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383004284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383004285 dimerization interface [polypeptide binding]; other site 469383004286 putative DNA binding site [nucleotide binding]; other site 469383004287 putative Zn2+ binding site [ion binding]; other site 469383004288 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 469383004289 putative hydrophobic ligand binding site [chemical binding]; other site 469383004290 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 469383004291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 469383004292 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 469383004293 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 469383004294 oligomer interface [polypeptide binding]; other site 469383004295 metal binding site [ion binding]; metal-binding site 469383004296 metal binding site [ion binding]; metal-binding site 469383004297 putative Cl binding site [ion binding]; other site 469383004298 basic sphincter; other site 469383004299 hydrophobic gate; other site 469383004300 periplasmic entrance; other site 469383004301 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 469383004302 active site 469383004303 catalytic residues [active] 469383004304 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 469383004305 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383004306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383004307 putative substrate translocation pore; other site 469383004308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 469383004309 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 469383004310 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 469383004311 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 469383004312 gating phenylalanine in ion channel; other site 469383004313 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 469383004314 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 469383004315 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 469383004316 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 469383004317 [4Fe-4S] binding site [ion binding]; other site 469383004318 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383004319 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383004320 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383004321 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 469383004322 molybdopterin cofactor binding site; other site 469383004323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383004324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383004325 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 469383004326 hexamer interface [polypeptide binding]; other site 469383004327 active site 2 [active] 469383004328 RDD family; Region: RDD; pfam06271 469383004329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383004331 active site 469383004332 phosphorylation site [posttranslational modification] 469383004333 intermolecular recognition site; other site 469383004334 dimerization interface [polypeptide binding]; other site 469383004335 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383004337 active site 469383004338 phosphorylation site [posttranslational modification] 469383004339 intermolecular recognition site; other site 469383004340 dimerization interface [polypeptide binding]; other site 469383004341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004342 DNA binding residues [nucleotide binding] 469383004343 Histidine kinase; Region: HisKA_3; pfam07730 469383004344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383004345 ATP binding site [chemical binding]; other site 469383004346 Mg2+ binding site [ion binding]; other site 469383004347 G-X-G motif; other site 469383004348 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 469383004349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 469383004350 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 469383004351 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383004352 dimer interface [polypeptide binding]; other site 469383004353 active site 469383004354 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 469383004355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383004356 substrate binding site [chemical binding]; other site 469383004357 oxyanion hole (OAH) forming residues; other site 469383004358 trimer interface [polypeptide binding]; other site 469383004359 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383004360 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383004361 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469383004362 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383004363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383004364 sequence-specific DNA binding site [nucleotide binding]; other site 469383004365 salt bridge; other site 469383004366 Cupin domain; Region: Cupin_2; pfam07883 469383004367 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 469383004368 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 469383004369 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 469383004370 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 469383004371 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 469383004372 Thioredoxin; Region: Thioredoxin_4; pfam13462 469383004373 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 469383004374 Predicted acetyltransferase [General function prediction only]; Region: COG2388 469383004375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004376 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383004377 NAD(P) binding site [chemical binding]; other site 469383004378 active site 469383004379 Cupin; Region: Cupin_6; pfam12852 469383004380 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 469383004381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383004382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004383 NAD(P) binding site [chemical binding]; other site 469383004384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004385 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 469383004386 NAD(P) binding site [chemical binding]; other site 469383004387 active site 469383004388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004389 active site 469383004390 Putative zinc-finger; Region: zf-HC2; pfam13490 469383004391 Anti-sigma-K factor rskA; Region: RskA; pfam10099 469383004392 RNA polymerase sigma factor; Provisional; Region: PRK12519 469383004393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383004394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383004395 DNA binding residues [nucleotide binding] 469383004396 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 469383004397 dinuclear metal binding motif [ion binding]; other site 469383004398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004400 DNA binding residues [nucleotide binding] 469383004401 AAA ATPase domain; Region: AAA_16; pfam13191 469383004402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004404 DNA binding residues [nucleotide binding] 469383004405 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 469383004406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383004407 motif II; other site 469383004408 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 469383004409 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 469383004410 Sulfate transporter family; Region: Sulfate_transp; pfam00916 469383004411 Sulfate transporter family; Region: Sulfate_transp; pfam00916 469383004412 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 469383004413 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 469383004414 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 469383004415 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 469383004416 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 469383004417 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383004418 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 469383004419 intersubunit interface [polypeptide binding]; other site 469383004420 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 469383004421 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 469383004422 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 469383004423 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 469383004424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383004425 motif II; other site 469383004426 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 469383004427 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 469383004428 active site 469383004429 inhibitor site; inhibition site 469383004430 dimer interface [polypeptide binding]; other site 469383004431 catalytic residue [active] 469383004432 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 469383004433 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383004434 NAD(P) binding site [chemical binding]; other site 469383004435 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 469383004436 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383004437 active site 469383004438 HIGH motif; other site 469383004439 nucleotide binding site [chemical binding]; other site 469383004440 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383004441 active site 469383004442 KMSKS motif; other site 469383004443 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 469383004444 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 469383004445 heme-binding site [chemical binding]; other site 469383004446 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383004447 dimer interface [polypeptide binding]; other site 469383004448 putative CheW interface [polypeptide binding]; other site 469383004449 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 469383004450 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 469383004451 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 469383004452 active site 469383004453 oxyanion hole [active] 469383004454 catalytic triad [active] 469383004455 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383004456 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 469383004457 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383004458 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 469383004459 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 469383004460 NAD(P) binding pocket [chemical binding]; other site 469383004461 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383004462 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 469383004463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383004464 catalytic residue [active] 469383004465 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383004466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004467 NAD(P) binding site [chemical binding]; other site 469383004468 active site 469383004469 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383004470 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 469383004471 NodB motif; other site 469383004472 putative active site [active] 469383004473 putative catalytic site [active] 469383004474 putative Zn binding site [ion binding]; other site 469383004475 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 469383004476 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383004477 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383004478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383004479 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383004480 DNA binding residues [nucleotide binding] 469383004481 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 469383004482 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 469383004483 tetrameric interface [polypeptide binding]; other site 469383004484 NAD binding site [chemical binding]; other site 469383004485 catalytic residues [active] 469383004486 substrate binding site [chemical binding]; other site 469383004487 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 469383004488 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 469383004489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004490 glucose-1-dehydrogenase; Provisional; Region: PRK08936 469383004491 NAD(P) binding site [chemical binding]; other site 469383004492 active site 469383004493 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 469383004494 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 469383004495 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469383004496 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383004497 active site 469383004498 catalytic tetrad [active] 469383004499 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383004500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004501 NAD(P) binding site [chemical binding]; other site 469383004502 active site 469383004503 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 469383004504 nudix motif; other site 469383004505 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 469383004506 Rubredoxin; Region: Rubredoxin; pfam00301 469383004507 iron binding site [ion binding]; other site 469383004508 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469383004509 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 469383004510 putative active site [active] 469383004511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383004512 S-adenosylmethionine binding site [chemical binding]; other site 469383004513 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383004514 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469383004515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383004516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383004517 active site 469383004518 phosphorylation site [posttranslational modification] 469383004519 intermolecular recognition site; other site 469383004520 dimerization interface [polypeptide binding]; other site 469383004521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383004522 DNA binding site [nucleotide binding] 469383004523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383004524 dimerization interface [polypeptide binding]; other site 469383004525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383004526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383004527 dimer interface [polypeptide binding]; other site 469383004528 phosphorylation site [posttranslational modification] 469383004529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383004530 ATP binding site [chemical binding]; other site 469383004531 Mg2+ binding site [ion binding]; other site 469383004532 G-X-G motif; other site 469383004533 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 469383004534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383004535 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 469383004536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383004537 Walker A/P-loop; other site 469383004538 ATP binding site [chemical binding]; other site 469383004539 Q-loop/lid; other site 469383004540 ABC transporter signature motif; other site 469383004541 Walker B; other site 469383004542 D-loop; other site 469383004543 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 469383004544 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 469383004545 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 469383004546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383004547 catalytic residue [active] 469383004548 biotin synthase; Region: bioB; TIGR00433 469383004549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383004550 FeS/SAM binding site; other site 469383004551 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 469383004552 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 469383004553 putative active site [active] 469383004554 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 469383004555 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 469383004556 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 469383004557 enoyl-CoA hydratase; Provisional; Region: PRK06127 469383004558 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383004559 substrate binding site [chemical binding]; other site 469383004560 oxyanion hole (OAH) forming residues; other site 469383004561 trimer interface [polypeptide binding]; other site 469383004562 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 469383004563 carboxyltransferase (CT) interaction site; other site 469383004564 biotinylation site [posttranslational modification]; other site 469383004565 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469383004566 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 469383004567 active site 469383004568 Putative esterase; Region: Esterase; pfam00756 469383004569 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383004570 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 469383004571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 469383004572 putative acyl-acceptor binding pocket; other site 469383004573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383004574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004575 active site 469383004576 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 469383004577 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 469383004578 dimer interface [polypeptide binding]; other site 469383004579 substrate binding site [chemical binding]; other site 469383004580 metal binding sites [ion binding]; metal-binding site 469383004581 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383004582 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 469383004583 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383004584 catalytic residue [active] 469383004585 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383004586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383004587 NAD(P) binding site [chemical binding]; other site 469383004588 active site 469383004589 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 469383004590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383004591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383004592 active site 469383004593 Cupin domain; Region: Cupin_2; cl17218 469383004594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383004595 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383004596 active site 469383004597 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383004598 enoyl-CoA hydratase; Validated; Region: PRK08139 469383004599 substrate binding site [chemical binding]; other site 469383004600 oxyanion hole (OAH) forming residues; other site 469383004601 trimer interface [polypeptide binding]; other site 469383004602 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 469383004603 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 469383004604 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 469383004605 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469383004606 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383004607 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383004608 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383004609 DNA binding residues [nucleotide binding] 469383004610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383004611 WHG domain; Region: WHG; pfam13305 469383004612 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 469383004613 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 469383004614 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 469383004615 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 469383004616 putative active site [active] 469383004617 catalytic triad [active] 469383004618 dimer interface [polypeptide binding]; other site 469383004619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383004620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383004621 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 469383004622 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 469383004623 EDD domain protein, DegV family; Region: DegV; TIGR00762 469383004624 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 469383004625 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 469383004626 C-terminal domain interface [polypeptide binding]; other site 469383004627 dimer interface [polypeptide binding]; other site 469383004628 GSH binding site (G-site) [chemical binding]; other site 469383004629 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 469383004630 putative GSH binding site [chemical binding]; other site 469383004631 catalytic residues [active] 469383004632 BolA-like protein; Region: BolA; pfam01722 469383004633 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 469383004634 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383004635 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383004636 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 469383004637 CAAX protease self-immunity; Region: Abi; pfam02517 469383004638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383004639 Histidine kinase; Region: HisKA_3; pfam07730 469383004640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383004642 active site 469383004643 phosphorylation site [posttranslational modification] 469383004644 intermolecular recognition site; other site 469383004645 dimerization interface [polypeptide binding]; other site 469383004646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004647 dimerization interface [polypeptide binding]; other site 469383004648 DNA binding residues [nucleotide binding] 469383004649 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 469383004650 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 469383004651 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 469383004652 substrate binding pocket [chemical binding]; other site 469383004653 dimer interface [polypeptide binding]; other site 469383004654 inhibitor binding site; inhibition site 469383004655 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 469383004656 B12 binding site [chemical binding]; other site 469383004657 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 469383004658 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 469383004659 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 469383004660 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 469383004661 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 469383004662 Permease; Region: Permease; pfam02405 469383004663 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 469383004664 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 469383004665 Walker A/P-loop; other site 469383004666 ATP binding site [chemical binding]; other site 469383004667 Q-loop/lid; other site 469383004668 ABC transporter signature motif; other site 469383004669 Walker B; other site 469383004670 D-loop; other site 469383004671 H-loop/switch region; other site 469383004672 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 469383004673 mce related protein; Region: MCE; pfam02470 469383004674 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 469383004675 mce related protein; Region: MCE; pfam02470 469383004676 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 469383004677 mce related protein; Region: MCE; pfam02470 469383004678 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 469383004679 mce related protein; Region: MCE; pfam02470 469383004680 mce related protein; Region: MCE; pfam02470 469383004681 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 469383004682 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 469383004683 mce related protein; Region: MCE; pfam02470 469383004684 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 469383004685 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 469383004686 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 469383004687 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 469383004688 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469383004689 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383004690 B3/4 domain; Region: B3_4; pfam03483 469383004691 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 469383004692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383004693 Zn binding site [ion binding]; other site 469383004694 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 469383004695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383004696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383004697 catalytic residue [active] 469383004698 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 469383004699 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 469383004700 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 469383004701 Nitrogen regulatory protein P-II; Region: P-II; smart00938 469383004702 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383004703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 469383004704 NMT1/THI5 like; Region: NMT1; pfam09084 469383004705 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383004706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383004707 dimer interface [polypeptide binding]; other site 469383004708 conserved gate region; other site 469383004709 ABC-ATPase subunit interface; other site 469383004710 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383004711 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383004712 Walker A/P-loop; other site 469383004713 ATP binding site [chemical binding]; other site 469383004714 Q-loop/lid; other site 469383004715 ABC transporter signature motif; other site 469383004716 Walker B; other site 469383004717 D-loop; other site 469383004718 H-loop/switch region; other site 469383004719 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 469383004720 MoxR-like ATPases [General function prediction only]; Region: COG0714 469383004721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383004722 Walker A motif; other site 469383004723 ATP binding site [chemical binding]; other site 469383004724 Walker B motif; other site 469383004725 arginine finger; other site 469383004726 PspC domain; Region: PspC; pfam04024 469383004727 PspC domain; Region: PspC; pfam04024 469383004728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383004729 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383004730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383004732 active site 469383004733 phosphorylation site [posttranslational modification] 469383004734 intermolecular recognition site; other site 469383004735 dimerization interface [polypeptide binding]; other site 469383004736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004737 DNA binding residues [nucleotide binding] 469383004738 dimerization interface [polypeptide binding]; other site 469383004739 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 469383004740 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383004741 calcium/proton exchanger (cax); Region: cax; TIGR00378 469383004742 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 469383004743 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 469383004744 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383004745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383004746 active site 469383004747 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 469383004748 Interdomain contacts; other site 469383004749 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 469383004750 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383004751 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383004752 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383004753 enoyl-CoA hydratase; Provisional; Region: PRK07658 469383004754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383004755 substrate binding site [chemical binding]; other site 469383004756 oxyanion hole (OAH) forming residues; other site 469383004757 trimer interface [polypeptide binding]; other site 469383004758 NAD-dependent deacetylase; Provisional; Region: PRK00481 469383004759 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 469383004760 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 469383004761 N-acetyl-D-glucosamine binding site [chemical binding]; other site 469383004762 catalytic residue [active] 469383004763 Peptidase family M23; Region: Peptidase_M23; pfam01551 469383004764 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 469383004765 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 469383004766 SCP-2 sterol transfer family; Region: SCP2; pfam02036 469383004767 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383004768 DNA binding residues [nucleotide binding] 469383004769 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 469383004770 cyclase homology domain; Region: CHD; cd07302 469383004771 nucleotidyl binding site; other site 469383004772 metal binding site [ion binding]; metal-binding site 469383004773 dimer interface [polypeptide binding]; other site 469383004774 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 469383004775 Ligand Binding Site [chemical binding]; other site 469383004776 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 469383004777 TilS substrate C-terminal domain; Region: TilS_C; smart00977 469383004778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469383004779 active site 469383004780 FtsH Extracellular; Region: FtsH_ext; pfam06480 469383004781 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 469383004782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383004783 Walker A motif; other site 469383004784 ATP binding site [chemical binding]; other site 469383004785 Walker B motif; other site 469383004786 arginine finger; other site 469383004787 Peptidase family M41; Region: Peptidase_M41; pfam01434 469383004788 dihydropteroate synthase; Region: DHPS; TIGR01496 469383004789 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 469383004790 substrate binding pocket [chemical binding]; other site 469383004791 dimer interface [polypeptide binding]; other site 469383004792 inhibitor binding site; inhibition site 469383004793 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 469383004794 homooctamer interface [polypeptide binding]; other site 469383004795 active site 469383004796 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 469383004797 catalytic center binding site [active] 469383004798 ATP binding site [chemical binding]; other site 469383004799 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 469383004800 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 469383004801 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 469383004802 N-terminal domain interface [polypeptide binding]; other site 469383004803 pantothenate kinase; Reviewed; Region: PRK13318 469383004804 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 469383004805 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 469383004806 FMN binding site [chemical binding]; other site 469383004807 active site 469383004808 catalytic residues [active] 469383004809 substrate binding site [chemical binding]; other site 469383004810 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 469383004811 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 469383004812 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 469383004813 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 469383004814 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 469383004815 putative anticodon binding site; other site 469383004816 dimer interface [polypeptide binding]; other site 469383004817 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 469383004818 motif 1; other site 469383004819 dimer interface [polypeptide binding]; other site 469383004820 active site 469383004821 motif 2; other site 469383004822 motif 3; other site 469383004823 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 469383004824 Clp amino terminal domain; Region: Clp_N; pfam02861 469383004825 Clp amino terminal domain; Region: Clp_N; pfam02861 469383004826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383004827 Walker A motif; other site 469383004828 ATP binding site [chemical binding]; other site 469383004829 Walker B motif; other site 469383004830 arginine finger; other site 469383004831 UvrB/uvrC motif; Region: UVR; pfam02151 469383004832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383004833 Walker A motif; other site 469383004834 ATP binding site [chemical binding]; other site 469383004835 Walker B motif; other site 469383004836 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 469383004837 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 469383004838 cystathionine gamma-lyase; Validated; Region: PRK07582 469383004839 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383004840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383004841 catalytic residue [active] 469383004842 DNA repair protein RadA; Provisional; Region: PRK11823 469383004843 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 469383004844 Walker A motif; other site 469383004845 ATP binding site [chemical binding]; other site 469383004846 Walker B motif; other site 469383004847 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 469383004848 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 469383004849 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 469383004850 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 469383004851 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 469383004852 substrate binding site; other site 469383004853 dimer interface; other site 469383004854 histidinol-phosphatase; Provisional; Region: PRK07328 469383004855 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 469383004856 active site 469383004857 dimer interface [polypeptide binding]; other site 469383004858 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 469383004859 homotrimer interaction site [polypeptide binding]; other site 469383004860 zinc binding site [ion binding]; other site 469383004861 CDP-binding sites; other site 469383004862 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383004863 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 469383004864 active site 469383004865 HIGH motif; other site 469383004866 nucleotide binding site [chemical binding]; other site 469383004867 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 469383004868 KMSKS motif; other site 469383004869 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 469383004870 tRNA binding surface [nucleotide binding]; other site 469383004871 anticodon binding site; other site 469383004872 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 469383004873 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 469383004874 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 469383004875 RNA polymerase factor sigma-70; Validated; Region: PRK08295 469383004876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383004877 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383004878 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 469383004879 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 469383004880 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 469383004881 putative active site [active] 469383004882 putative substrate binding site [chemical binding]; other site 469383004883 putative cosubstrate binding site; other site 469383004884 catalytic site [active] 469383004885 Domain of unknown function (DUF202); Region: DUF202; pfam02656 469383004886 CHAD domain; Region: CHAD; cl10506 469383004887 CHAD domain; Region: CHAD; pfam05235 469383004888 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 469383004889 putative active site; other site 469383004890 putative metal binding residues [ion binding]; other site 469383004891 signature motif; other site 469383004892 putative triphosphate binding site [ion binding]; other site 469383004893 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 469383004894 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 469383004895 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 469383004896 active site 469383004897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383004898 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 469383004899 AAA ATPase domain; Region: AAA_16; pfam13191 469383004900 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383004901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383004902 DNA binding residues [nucleotide binding] 469383004903 dimerization interface [polypeptide binding]; other site 469383004904 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383004905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383004906 Walker A/P-loop; other site 469383004907 ATP binding site [chemical binding]; other site 469383004908 Q-loop/lid; other site 469383004909 ABC transporter signature motif; other site 469383004910 Walker B; other site 469383004911 D-loop; other site 469383004912 H-loop/switch region; other site 469383004913 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 469383004914 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 469383004915 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 469383004916 Permease; Region: Permease; pfam02405 469383004917 MMPL family; Region: MMPL; pfam03176 469383004918 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469383004919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383004920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383004921 putative substrate translocation pore; other site 469383004922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383004923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383004924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 469383004925 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 469383004926 dimer interface [polypeptide binding]; other site 469383004927 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 469383004928 putative radical transfer pathway; other site 469383004929 diiron center [ion binding]; other site 469383004930 tyrosyl radical; other site 469383004931 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 469383004932 ATP cone domain; Region: ATP-cone; pfam03477 469383004933 Class I ribonucleotide reductase; Region: RNR_I; cd01679 469383004934 active site 469383004935 dimer interface [polypeptide binding]; other site 469383004936 catalytic residues [active] 469383004937 effector binding site; other site 469383004938 R2 peptide binding site; other site 469383004939 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 469383004940 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 469383004941 THF binding site; other site 469383004942 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 469383004943 substrate binding site [chemical binding]; other site 469383004944 THF binding site; other site 469383004945 zinc-binding site [ion binding]; other site 469383004946 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 469383004947 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 469383004948 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 469383004949 Soluble P-type ATPase [General function prediction only]; Region: COG4087 469383004950 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 469383004951 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 469383004952 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 469383004953 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 469383004954 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 469383004955 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 469383004956 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 469383004957 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 469383004958 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 469383004959 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 469383004960 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 469383004961 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 469383004962 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 469383004963 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 469383004964 Domain of unknown function DUF20; Region: UPF0118; pfam01594 469383004965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383004966 non-specific DNA binding site [nucleotide binding]; other site 469383004967 salt bridge; other site 469383004968 sequence-specific DNA binding site [nucleotide binding]; other site 469383004969 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 469383004970 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383004971 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 469383004972 catalytic residue [active] 469383004973 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 469383004974 Peptidase family M23; Region: Peptidase_M23; pfam01551 469383004975 Baseplate J-like protein; Region: Baseplate_J; cl01294 469383004976 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383004977 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 469383004978 putative active site [active] 469383004979 putative metal binding site [ion binding]; other site 469383004980 Phage Tail Collar Domain; Region: Collar; pfam07484 469383004981 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 469383004982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 469383004983 sequence-specific DNA binding site [nucleotide binding]; other site 469383004984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383004985 non-specific DNA binding site [nucleotide binding]; other site 469383004986 salt bridge; other site 469383004987 sequence-specific DNA binding site [nucleotide binding]; other site 469383004988 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 469383004989 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 469383004990 active site 469383004991 catalytic residues [active] 469383004992 DNA binding site [nucleotide binding] 469383004993 Int/Topo IB signature motif; other site 469383004994 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 469383004995 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 469383004996 putative acyl-acceptor binding pocket; other site 469383004997 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 469383004998 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 469383004999 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 469383005000 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383005001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383005002 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383005003 DNA binding residues [nucleotide binding] 469383005004 Rhomboid family; Region: Rhomboid; pfam01694 469383005005 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383005006 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 469383005007 intersubunit interface [polypeptide binding]; other site 469383005008 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 469383005009 aromatic arch; other site 469383005010 DCoH dimer interaction site [polypeptide binding]; other site 469383005011 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 469383005012 DCoH tetramer interaction site [polypeptide binding]; other site 469383005013 substrate binding site [chemical binding]; other site 469383005014 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 469383005015 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383005016 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383005017 PAS domain S-box; Region: sensory_box; TIGR00229 469383005018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383005019 putative active site [active] 469383005020 heme pocket [chemical binding]; other site 469383005021 PAS domain S-box; Region: sensory_box; TIGR00229 469383005022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383005023 putative active site [active] 469383005024 heme pocket [chemical binding]; other site 469383005025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383005026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383005027 metal binding site [ion binding]; metal-binding site 469383005028 active site 469383005029 I-site; other site 469383005030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383005031 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383005032 metal binding site [ion binding]; metal-binding site 469383005033 substrate binding pocket [chemical binding]; other site 469383005034 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 469383005035 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 469383005036 generic binding surface II; other site 469383005037 generic binding surface I; other site 469383005038 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383005039 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 469383005040 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 469383005041 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 469383005042 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 469383005043 Peptidase family M48; Region: Peptidase_M48; cl12018 469383005044 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 469383005045 Peptidase family M23; Region: Peptidase_M23; pfam01551 469383005046 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 469383005047 diaminopimelate decarboxylase; Region: lysA; TIGR01048 469383005048 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 469383005049 active site 469383005050 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383005051 substrate binding site [chemical binding]; other site 469383005052 catalytic residues [active] 469383005053 dimer interface [polypeptide binding]; other site 469383005054 homoserine dehydrogenase; Provisional; Region: PRK06349 469383005055 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 469383005056 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 469383005057 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 469383005058 threonine synthase; Reviewed; Region: PRK06721 469383005059 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 469383005060 homodimer interface [polypeptide binding]; other site 469383005061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383005062 catalytic residue [active] 469383005063 homoserine kinase; Provisional; Region: PRK01212 469383005064 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 469383005065 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 469383005066 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383005067 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 469383005068 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 469383005069 Magnesium ion binding site [ion binding]; other site 469383005070 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469383005071 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469383005072 phosphopeptide binding site; other site 469383005073 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 469383005074 hydrophobic ligand binding site; other site 469383005075 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469383005076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469383005077 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 469383005078 DNA topoisomerase III; Provisional; Region: PRK07726 469383005079 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 469383005080 active site 469383005081 putative interdomain interaction site [polypeptide binding]; other site 469383005082 putative metal-binding site [ion binding]; other site 469383005083 putative nucleotide binding site [chemical binding]; other site 469383005084 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 469383005085 domain I; other site 469383005086 DNA binding groove [nucleotide binding] 469383005087 phosphate binding site [ion binding]; other site 469383005088 domain II; other site 469383005089 domain III; other site 469383005090 nucleotide binding site [chemical binding]; other site 469383005091 catalytic site [active] 469383005092 domain IV; other site 469383005093 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 469383005094 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 469383005095 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 469383005096 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 469383005097 Part of AAA domain; Region: AAA_19; pfam13245 469383005098 Family description; Region: UvrD_C_2; pfam13538 469383005099 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 469383005100 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 469383005101 active site 2 [active] 469383005102 active site 1 [active] 469383005103 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 469383005104 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 469383005105 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 469383005106 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383005107 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383005108 DNA binding residues [nucleotide binding] 469383005109 GAF domain; Region: GAF; cl17456 469383005110 GAF domain; Region: GAF_2; pfam13185 469383005111 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 469383005112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383005113 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469383005114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383005115 DNA binding residues [nucleotide binding] 469383005116 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 469383005117 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 469383005118 putative DNA binding site [nucleotide binding]; other site 469383005119 putative homodimer interface [polypeptide binding]; other site 469383005120 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 469383005121 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383005122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383005123 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 469383005124 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 469383005125 active site 469383005126 dimer interface [polypeptide binding]; other site 469383005127 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 469383005128 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 469383005129 active site 469383005130 FMN binding site [chemical binding]; other site 469383005131 substrate binding site [chemical binding]; other site 469383005132 3Fe-4S cluster binding site [ion binding]; other site 469383005133 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 469383005134 domain interface; other site 469383005135 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 469383005136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383005137 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 469383005138 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 469383005139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383005140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383005141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383005142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383005143 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 469383005144 Putative zinc-finger; Region: zf-HC2; pfam13490 469383005145 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 469383005146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383005147 sequence-specific DNA binding site [nucleotide binding]; other site 469383005148 salt bridge; other site 469383005149 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 469383005150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383005151 motif II; other site 469383005152 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 469383005153 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 469383005154 anti sigma factor interaction site; other site 469383005155 regulatory phosphorylation site [posttranslational modification]; other site 469383005156 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 469383005157 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 469383005158 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 469383005159 active site 469383005160 catalytic residues [active] 469383005161 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 469383005162 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 469383005163 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383005164 Peptidase family M28; Region: Peptidase_M28; pfam04389 469383005165 metal binding site [ion binding]; metal-binding site 469383005166 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 469383005167 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 469383005168 Catalytic site [active] 469383005169 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 469383005170 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 469383005171 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383005172 active site 469383005173 metal binding site [ion binding]; metal-binding site 469383005174 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383005175 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469383005176 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 469383005177 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 469383005178 Cu(I) binding site [ion binding]; other site 469383005179 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 469383005180 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 469383005181 active site residue [active] 469383005182 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 469383005183 ATP binding site [chemical binding]; other site 469383005184 substrate interface [chemical binding]; other site 469383005185 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 469383005186 MoaE interaction surface [polypeptide binding]; other site 469383005187 MoeB interaction surface [polypeptide binding]; other site 469383005188 thiocarboxylated glycine; other site 469383005189 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 469383005190 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 469383005191 dimer interface [polypeptide binding]; other site 469383005192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383005193 catalytic residue [active] 469383005194 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 469383005195 dinuclear metal binding motif [ion binding]; other site 469383005196 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 469383005197 dinuclear metal binding motif [ion binding]; other site 469383005198 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 469383005199 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 469383005200 MPN+ (JAMM) motif; other site 469383005201 Zinc-binding site [ion binding]; other site 469383005202 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 469383005203 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 469383005204 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 469383005205 active site 469383005206 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 469383005207 Protein of unknown function (DUF1152); Region: DUF1152; pfam06626 469383005208 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 469383005209 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383005210 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 469383005211 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383005212 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383005213 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383005214 L-aspartate oxidase; Provisional; Region: PRK06175 469383005215 FAD binding domain; Region: FAD_binding_2; pfam00890 469383005216 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 469383005217 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 469383005218 active site 469383005219 Zn binding site [ion binding]; other site 469383005220 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383005221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383005222 glutamate racemase; Provisional; Region: PRK00865 469383005223 ribonuclease PH; Reviewed; Region: rph; PRK00173 469383005224 Ribonuclease PH; Region: RNase_PH_bact; cd11362 469383005225 hexamer interface [polypeptide binding]; other site 469383005226 active site 469383005227 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 469383005228 active site 469383005229 dimerization interface [polypeptide binding]; other site 469383005230 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 469383005231 IHF dimer interface [polypeptide binding]; other site 469383005232 IHF - DNA interface [nucleotide binding]; other site 469383005233 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 469383005234 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 469383005235 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 469383005236 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 469383005237 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 469383005238 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 469383005239 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 469383005240 putative substrate binding site [chemical binding]; other site 469383005241 putative ATP binding site [chemical binding]; other site 469383005242 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 469383005243 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 469383005244 active site 469383005245 GMP synthase; Reviewed; Region: guaA; PRK00074 469383005246 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 469383005247 AMP/PPi binding site [chemical binding]; other site 469383005248 candidate oxyanion hole; other site 469383005249 catalytic triad [active] 469383005250 potential glutamine specificity residues [chemical binding]; other site 469383005251 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 469383005252 ATP Binding subdomain [chemical binding]; other site 469383005253 Ligand Binding sites [chemical binding]; other site 469383005254 Dimerization subdomain; other site 469383005255 NB-ARC domain; Region: NB-ARC; pfam00931 469383005256 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 469383005257 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 469383005258 Peptidase family M23; Region: Peptidase_M23; pfam01551 469383005259 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 469383005260 23S rRNA interface [nucleotide binding]; other site 469383005261 L3 interface [polypeptide binding]; other site 469383005262 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 469383005263 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 469383005264 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 469383005265 active site 469383005266 substrate binding site [chemical binding]; other site 469383005267 metal binding site [ion binding]; metal-binding site 469383005268 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 469383005269 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 469383005270 glutaminase active site [active] 469383005271 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469383005272 dimer interface [polypeptide binding]; other site 469383005273 active site 469383005274 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 469383005275 dimer interface [polypeptide binding]; other site 469383005276 active site 469383005277 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 469383005278 Uncharacterized conserved protein [Function unknown]; Region: COG0062 469383005279 putative carbohydrate kinase; Provisional; Region: PRK10565 469383005280 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 469383005281 putative substrate binding site [chemical binding]; other site 469383005282 putative ATP binding site [chemical binding]; other site 469383005283 FOG: CBS domain [General function prediction only]; Region: COG0517 469383005284 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 469383005285 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 469383005286 alanine racemase; Reviewed; Region: alr; PRK00053 469383005287 active site 469383005288 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383005289 dimer interface [polypeptide binding]; other site 469383005290 substrate binding site [chemical binding]; other site 469383005291 catalytic residues [active] 469383005292 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 469383005293 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 469383005294 metal binding triad [ion binding]; metal-binding site 469383005295 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 469383005296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383005297 Zn2+ binding site [ion binding]; other site 469383005298 Mg2+ binding site [ion binding]; other site 469383005299 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383005300 Peptidase family M28; Region: Peptidase_M28; pfam04389 469383005301 metal binding site [ion binding]; metal-binding site 469383005302 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 469383005303 HIT family signature motif; other site 469383005304 catalytic residue [active] 469383005305 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 469383005306 DNA-binding site [nucleotide binding]; DNA binding site 469383005307 RNA-binding motif; other site 469383005308 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383005309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383005310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383005311 Cytochrome c; Region: Cytochrom_C; pfam00034 469383005312 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 469383005313 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 469383005314 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 469383005315 Subunit I/III interface [polypeptide binding]; other site 469383005316 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 469383005317 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 469383005318 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 469383005319 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 469383005320 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 469383005321 Cytochrome c; Region: Cytochrom_C; pfam00034 469383005322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383005323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383005324 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 469383005325 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 469383005326 UbiA prenyltransferase family; Region: UbiA; pfam01040 469383005327 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 469383005328 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 469383005329 D-pathway; other site 469383005330 Putative ubiquinol binding site [chemical binding]; other site 469383005331 Low-spin heme (heme b) binding site [chemical binding]; other site 469383005332 Putative water exit pathway; other site 469383005333 Binuclear center (heme o3/CuB) [ion binding]; other site 469383005334 K-pathway; other site 469383005335 Putative proton exit pathway; other site 469383005336 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 469383005337 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 469383005338 enoyl-CoA hydratase; Provisional; Region: PRK08140 469383005339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383005340 substrate binding site [chemical binding]; other site 469383005341 oxyanion hole (OAH) forming residues; other site 469383005342 trimer interface [polypeptide binding]; other site 469383005343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 469383005344 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 469383005345 active site 469383005346 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 469383005347 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 469383005348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383005349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383005350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005352 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 469383005353 putative active site [active] 469383005354 putative CoA binding site [chemical binding]; other site 469383005355 nudix motif; other site 469383005356 metal binding site [ion binding]; metal-binding site 469383005357 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 469383005358 Uncharacterized conserved protein [Function unknown]; Region: COG4198 469383005359 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 469383005360 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 469383005361 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383005362 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383005363 Family description; Region: VCBS; pfam13517 469383005364 Family description; Region: VCBS; pfam13517 469383005365 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 469383005366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383005367 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383005368 FAD binding domain; Region: FAD_binding_4; pfam01565 469383005369 Berberine and berberine like; Region: BBE; pfam08031 469383005370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383005371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383005372 DNA binding residues [nucleotide binding] 469383005373 dimerization interface [polypeptide binding]; other site 469383005374 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 469383005375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383005376 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383005377 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383005378 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383005379 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383005380 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383005381 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383005382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383005383 dimer interface [polypeptide binding]; other site 469383005384 conserved gate region; other site 469383005385 putative PBP binding loops; other site 469383005386 ABC-ATPase subunit interface; other site 469383005387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383005388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383005389 dimer interface [polypeptide binding]; other site 469383005390 conserved gate region; other site 469383005391 putative PBP binding loops; other site 469383005392 ABC-ATPase subunit interface; other site 469383005393 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383005394 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005395 Walker A/P-loop; other site 469383005396 ATP binding site [chemical binding]; other site 469383005397 Q-loop/lid; other site 469383005398 ABC transporter signature motif; other site 469383005399 Walker B; other site 469383005400 D-loop; other site 469383005401 H-loop/switch region; other site 469383005402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383005403 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 469383005404 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005405 Walker A/P-loop; other site 469383005406 ATP binding site [chemical binding]; other site 469383005407 Q-loop/lid; other site 469383005408 ABC transporter signature motif; other site 469383005409 Walker B; other site 469383005410 D-loop; other site 469383005411 H-loop/switch region; other site 469383005412 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 469383005413 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 469383005414 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 469383005415 Strictosidine synthase; Region: Str_synth; pfam03088 469383005416 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383005417 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383005418 metal binding site [ion binding]; metal-binding site 469383005419 substrate binding pocket [chemical binding]; other site 469383005420 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 469383005421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 469383005422 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 469383005423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005424 NAD(P) binding site [chemical binding]; other site 469383005425 active site 469383005426 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 469383005427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005428 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 469383005429 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383005430 NAD(P) binding site [chemical binding]; other site 469383005431 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383005432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005433 NAD(P) binding site [chemical binding]; other site 469383005434 active site 469383005435 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 469383005436 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383005437 tetramer interface [polypeptide binding]; other site 469383005438 TPP-binding site [chemical binding]; other site 469383005439 heterodimer interface [polypeptide binding]; other site 469383005440 phosphorylation loop region [posttranslational modification] 469383005441 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383005442 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383005443 alpha subunit interface [polypeptide binding]; other site 469383005444 TPP binding site [chemical binding]; other site 469383005445 heterodimer interface [polypeptide binding]; other site 469383005446 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383005447 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383005448 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383005449 E3 interaction surface; other site 469383005450 lipoyl attachment site [posttranslational modification]; other site 469383005451 e3 binding domain; Region: E3_binding; pfam02817 469383005452 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383005453 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383005454 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383005455 active site 469383005456 metal binding site [ion binding]; metal-binding site 469383005457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005458 NAD(P) binding site [chemical binding]; other site 469383005459 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 469383005460 active site 469383005461 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 469383005462 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383005463 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383005464 classical (c) SDRs; Region: SDR_c; cd05233 469383005465 NAD(P) binding site [chemical binding]; other site 469383005466 active site 469383005467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383005468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383005469 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 469383005470 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383005471 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383005472 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383005473 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383005474 Cytochrome P450; Region: p450; cl12078 469383005475 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 469383005476 ferredoxin-NADP+ reductase; Region: PLN02852 469383005477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383005478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383005479 non-specific DNA binding site [nucleotide binding]; other site 469383005480 salt bridge; other site 469383005481 sequence-specific DNA binding site [nucleotide binding]; other site 469383005482 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383005483 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 469383005484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383005485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383005486 Walker A/P-loop; other site 469383005487 ATP binding site [chemical binding]; other site 469383005488 Q-loop/lid; other site 469383005489 ABC transporter signature motif; other site 469383005490 Walker B; other site 469383005491 D-loop; other site 469383005492 H-loop/switch region; other site 469383005493 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 469383005494 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383005495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383005496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383005497 Walker A/P-loop; other site 469383005498 ATP binding site [chemical binding]; other site 469383005499 Q-loop/lid; other site 469383005500 ABC transporter signature motif; other site 469383005501 Walker B; other site 469383005502 D-loop; other site 469383005503 H-loop/switch region; other site 469383005504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383005505 Walker A/P-loop; other site 469383005506 ATP binding site [chemical binding]; other site 469383005507 Q-loop/lid; other site 469383005508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383005509 dimerization interface [polypeptide binding]; other site 469383005510 putative DNA binding site [nucleotide binding]; other site 469383005511 putative Zn2+ binding site [ion binding]; other site 469383005512 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 469383005513 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 469383005514 catalytic residue [active] 469383005515 putative FPP diphosphate binding site; other site 469383005516 putative FPP binding hydrophobic cleft; other site 469383005517 dimer interface [polypeptide binding]; other site 469383005518 putative IPP diphosphate binding site; other site 469383005519 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 469383005520 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 469383005521 OsmC-like protein; Region: OsmC; pfam02566 469383005522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 469383005523 binding surface 469383005524 TPR motif; other site 469383005525 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 469383005526 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383005527 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 469383005528 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383005529 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 469383005530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383005531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 469383005532 dimerization interface [polypeptide binding]; other site 469383005533 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383005534 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 469383005535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383005536 S-adenosylmethionine binding site [chemical binding]; other site 469383005537 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383005538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383005539 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 469383005540 active site 469383005541 NAD binding site [chemical binding]; other site 469383005542 Predicted esterase [General function prediction only]; Region: COG0400 469383005543 putative hydrolase; Provisional; Region: PRK11460 469383005544 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 469383005545 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 469383005546 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 469383005547 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383005548 putative NAD(P) binding site [chemical binding]; other site 469383005549 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 469383005550 nucleoside/Zn binding site; other site 469383005551 dimer interface [polypeptide binding]; other site 469383005552 catalytic motif [active] 469383005553 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383005554 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383005555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383005556 Walker A/P-loop; other site 469383005557 ATP binding site [chemical binding]; other site 469383005558 Q-loop/lid; other site 469383005559 ABC transporter signature motif; other site 469383005560 Walker B; other site 469383005561 D-loop; other site 469383005562 H-loop/switch region; other site 469383005563 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383005564 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469383005565 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 469383005566 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 469383005567 Walker A/P-loop; other site 469383005568 ATP binding site [chemical binding]; other site 469383005569 Q-loop/lid; other site 469383005570 ABC transporter signature motif; other site 469383005571 Walker B; other site 469383005572 D-loop; other site 469383005573 H-loop/switch region; other site 469383005574 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 469383005575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383005576 dimer interface [polypeptide binding]; other site 469383005577 conserved gate region; other site 469383005578 putative PBP binding loops; other site 469383005579 ABC-ATPase subunit interface; other site 469383005580 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469383005581 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 469383005582 substrate binding pocket [chemical binding]; other site 469383005583 membrane-bound complex binding site; other site 469383005584 hinge residues; other site 469383005585 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 469383005586 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 469383005587 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 469383005588 G1 box; other site 469383005589 putative GEF interaction site [polypeptide binding]; other site 469383005590 GTP/Mg2+ binding site [chemical binding]; other site 469383005591 Switch I region; other site 469383005592 G2 box; other site 469383005593 G3 box; other site 469383005594 Switch II region; other site 469383005595 G4 box; other site 469383005596 G5 box; other site 469383005597 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 469383005598 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 469383005599 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383005600 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383005601 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383005602 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383005603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383005604 non-specific DNA binding site [nucleotide binding]; other site 469383005605 salt bridge; other site 469383005606 sequence-specific DNA binding site [nucleotide binding]; other site 469383005607 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 469383005608 active site 469383005609 DNA binding site [nucleotide binding] 469383005610 Int/Topo IB signature motif; other site 469383005611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383005612 non-specific DNA binding site [nucleotide binding]; other site 469383005613 salt bridge; other site 469383005614 sequence-specific DNA binding site [nucleotide binding]; other site 469383005615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 469383005616 active site 469383005617 DNA binding site [nucleotide binding] 469383005618 Int/Topo IB signature motif; other site 469383005619 AAA domain; Region: AAA_31; pfam13614 469383005620 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 469383005621 P-loop; other site 469383005622 Magnesium ion binding site [ion binding]; other site 469383005623 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 469383005624 Magnesium ion binding site [ion binding]; other site 469383005625 SIR2-like domain; Region: SIR2_2; pfam13289 469383005626 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 469383005627 homotetrameric interface [polypeptide binding]; other site 469383005628 putative active site [active] 469383005629 metal binding site [ion binding]; metal-binding site 469383005630 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383005631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383005632 DNA-binding site [nucleotide binding]; DNA binding site 469383005633 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383005634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383005635 hypothetical protein; Provisional; Region: PRK06102 469383005636 Amidase; Region: Amidase; cl11426 469383005637 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383005638 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383005639 ligand binding site [chemical binding]; other site 469383005640 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383005641 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383005642 Walker A/P-loop; other site 469383005643 ATP binding site [chemical binding]; other site 469383005644 Q-loop/lid; other site 469383005645 ABC transporter signature motif; other site 469383005646 Walker B; other site 469383005647 D-loop; other site 469383005648 H-loop/switch region; other site 469383005649 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383005650 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383005651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383005652 TM-ABC transporter signature motif; other site 469383005653 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 469383005654 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 469383005655 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 469383005656 active site 469383005657 catalytic site [active] 469383005658 Zn binding site [ion binding]; other site 469383005659 tetramer interface [polypeptide binding]; other site 469383005660 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383005661 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 469383005662 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383005663 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 469383005664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383005665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383005666 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383005667 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383005668 ligand binding site [chemical binding]; other site 469383005669 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383005670 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383005671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383005672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383005673 DNA binding residues [nucleotide binding] 469383005674 dimerization interface [polypeptide binding]; other site 469383005675 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 469383005676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383005677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383005678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005679 NAD(P) binding site [chemical binding]; other site 469383005680 active site 469383005681 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 469383005682 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383005683 substrate binding site [chemical binding]; other site 469383005684 oxyanion hole (OAH) forming residues; other site 469383005685 trimer interface [polypeptide binding]; other site 469383005686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005687 NAD(P) binding site [chemical binding]; other site 469383005688 active site 469383005689 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 469383005690 ABC1 family; Region: ABC1; pfam03109 469383005691 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383005692 active site 469383005693 ATP binding site [chemical binding]; other site 469383005694 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 469383005695 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383005696 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383005697 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383005698 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383005699 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383005700 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383005701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383005702 dimer interface [polypeptide binding]; other site 469383005703 conserved gate region; other site 469383005704 ABC-ATPase subunit interface; other site 469383005705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383005706 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383005707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005708 Walker A/P-loop; other site 469383005709 ATP binding site [chemical binding]; other site 469383005710 Q-loop/lid; other site 469383005711 ABC transporter signature motif; other site 469383005712 Walker B; other site 469383005713 D-loop; other site 469383005714 H-loop/switch region; other site 469383005715 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383005716 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383005717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005718 Walker A/P-loop; other site 469383005719 ATP binding site [chemical binding]; other site 469383005720 Q-loop/lid; other site 469383005721 ABC transporter signature motif; other site 469383005722 Walker B; other site 469383005723 D-loop; other site 469383005724 H-loop/switch region; other site 469383005725 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 469383005726 active site 469383005727 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 469383005728 DUF35 OB-fold domain; Region: DUF35; pfam01796 469383005729 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 469383005730 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 469383005731 active site 469383005732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383005733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383005734 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383005735 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383005736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383005737 NAD(P) binding site [chemical binding]; other site 469383005738 active site 469383005739 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 469383005740 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 469383005741 acyl-activating enzyme (AAE) consensus motif; other site 469383005742 putative AMP binding site [chemical binding]; other site 469383005743 putative active site [active] 469383005744 putative CoA binding site [chemical binding]; other site 469383005745 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 469383005746 active site 469383005747 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 469383005748 classical (c) SDRs; Region: SDR_c; cd05233 469383005749 NAD(P) binding site [chemical binding]; other site 469383005750 active site 469383005751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383005752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383005753 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383005754 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 469383005755 dimer interface [polypeptide binding]; other site 469383005756 active site 469383005757 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 469383005758 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 469383005759 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 469383005760 acyl-activating enzyme (AAE) consensus motif; other site 469383005761 putative AMP binding site [chemical binding]; other site 469383005762 putative active site [active] 469383005763 putative CoA binding site [chemical binding]; other site 469383005764 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 469383005765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383005766 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469383005767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383005768 DNA binding residues [nucleotide binding] 469383005769 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 469383005770 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 469383005771 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 469383005772 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 469383005773 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 469383005774 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 469383005775 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 469383005776 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 469383005777 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383005778 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 469383005779 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 469383005780 iron-sulfur cluster [ion binding]; other site 469383005781 [2Fe-2S] cluster binding site [ion binding]; other site 469383005782 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383005783 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 469383005784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383005785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383005786 oxidoreductase; Provisional; Region: PRK06196 469383005787 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 469383005788 putative NAD(P) binding site [chemical binding]; other site 469383005789 active site 469383005790 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383005791 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383005792 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383005793 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 469383005794 classical (c) SDRs; Region: SDR_c; cd05233 469383005795 NAD(P) binding site [chemical binding]; other site 469383005796 active site 469383005797 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383005798 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383005799 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383005800 ligand binding site [chemical binding]; other site 469383005801 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383005802 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383005803 Walker A/P-loop; other site 469383005804 ATP binding site [chemical binding]; other site 469383005805 Q-loop/lid; other site 469383005806 ABC transporter signature motif; other site 469383005807 Walker B; other site 469383005808 D-loop; other site 469383005809 H-loop/switch region; other site 469383005810 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383005811 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383005812 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383005813 TM-ABC transporter signature motif; other site 469383005814 EthD domain; Region: EthD; pfam07110 469383005815 SnoaL-like domain; Region: SnoaL_3; pfam13474 469383005816 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 469383005817 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 469383005818 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u11; cd10942 469383005819 putative active site [active] 469383005820 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383005821 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383005822 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383005823 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 469383005824 Phosphotransferase enzyme family; Region: APH; pfam01636 469383005825 enolase; Provisional; Region: eno; PRK00077 469383005826 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 469383005827 dimer interface [polypeptide binding]; other site 469383005828 metal binding site [ion binding]; metal-binding site 469383005829 substrate binding pocket [chemical binding]; other site 469383005830 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 469383005831 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 469383005832 ligand binding site [chemical binding]; other site 469383005833 NAD binding site [chemical binding]; other site 469383005834 catalytic site [active] 469383005835 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383005836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383005837 DNA-binding site [nucleotide binding]; DNA binding site 469383005838 FCD domain; Region: FCD; pfam07729 469383005839 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 469383005840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383005841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383005842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469383005843 dimerization interface [polypeptide binding]; other site 469383005844 hypothetical protein; Provisional; Region: PRK01346 469383005845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383005846 Coenzyme A binding pocket [chemical binding]; other site 469383005847 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383005848 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383005849 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383005850 classical (c) SDRs; Region: SDR_c; cd05233 469383005851 NAD(P) binding site [chemical binding]; other site 469383005852 active site 469383005853 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 469383005854 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383005855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383005856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383005857 dimer interface [polypeptide binding]; other site 469383005858 conserved gate region; other site 469383005859 putative PBP binding loops; other site 469383005860 ABC-ATPase subunit interface; other site 469383005861 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383005862 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 469383005863 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 469383005864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005865 Walker A/P-loop; other site 469383005866 ATP binding site [chemical binding]; other site 469383005867 Q-loop/lid; other site 469383005868 ABC transporter signature motif; other site 469383005869 Walker B; other site 469383005870 D-loop; other site 469383005871 H-loop/switch region; other site 469383005872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383005873 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005874 Walker A/P-loop; other site 469383005875 ATP binding site [chemical binding]; other site 469383005876 Q-loop/lid; other site 469383005877 ABC transporter signature motif; other site 469383005878 Walker B; other site 469383005879 D-loop; other site 469383005880 H-loop/switch region; other site 469383005881 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 469383005882 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383005883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383005884 catalytic residue [active] 469383005885 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 469383005886 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 469383005887 tetrameric interface [polypeptide binding]; other site 469383005888 NAD binding site [chemical binding]; other site 469383005889 catalytic residues [active] 469383005890 substrate binding site [chemical binding]; other site 469383005891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383005892 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 469383005893 inhibitor-cofactor binding pocket; inhibition site 469383005894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383005895 catalytic residue [active] 469383005896 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383005897 hydroxyglutarate oxidase; Provisional; Region: PRK11728 469383005898 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 469383005899 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 469383005900 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383005901 acyl-activating enzyme (AAE) consensus motif; other site 469383005902 AMP binding site [chemical binding]; other site 469383005903 active site 469383005904 CoA binding site [chemical binding]; other site 469383005905 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383005906 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383005907 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383005908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383005909 dimer interface [polypeptide binding]; other site 469383005910 conserved gate region; other site 469383005911 putative PBP binding loops; other site 469383005912 ABC-ATPase subunit interface; other site 469383005913 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383005914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383005915 dimer interface [polypeptide binding]; other site 469383005916 conserved gate region; other site 469383005917 putative PBP binding loops; other site 469383005918 ABC-ATPase subunit interface; other site 469383005919 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 469383005920 active site 469383005921 substrate binding pocket [chemical binding]; other site 469383005922 homodimer interaction site [polypeptide binding]; other site 469383005923 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 469383005924 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 469383005925 Strictosidine synthase; Region: Str_synth; pfam03088 469383005926 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383005927 Amidase; Region: Amidase; cl11426 469383005928 Amidase; Region: Amidase; cl11426 469383005929 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383005930 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005931 Walker A/P-loop; other site 469383005932 ATP binding site [chemical binding]; other site 469383005933 Q-loop/lid; other site 469383005934 ABC transporter signature motif; other site 469383005935 Walker B; other site 469383005936 D-loop; other site 469383005937 H-loop/switch region; other site 469383005938 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383005939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383005940 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383005941 Walker A/P-loop; other site 469383005942 ATP binding site [chemical binding]; other site 469383005943 Q-loop/lid; other site 469383005944 ABC transporter signature motif; other site 469383005945 Walker B; other site 469383005946 D-loop; other site 469383005947 H-loop/switch region; other site 469383005948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383005949 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 469383005950 amidase; Provisional; Region: PRK07869 469383005951 Amidase; Region: Amidase; cl11426 469383005952 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 469383005953 Coenzyme A transferase; Region: CoA_trans; cl17247 469383005954 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383005955 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383005956 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383005957 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383005958 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383005959 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 469383005960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383005961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383005962 active site 469383005963 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 469383005964 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 469383005965 putative ligand binding site [chemical binding]; other site 469383005966 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 469383005967 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383005968 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383005969 TM-ABC transporter signature motif; other site 469383005970 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383005971 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383005972 TM-ABC transporter signature motif; other site 469383005973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383005974 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383005975 Walker A/P-loop; other site 469383005976 ATP binding site [chemical binding]; other site 469383005977 Q-loop/lid; other site 469383005978 ABC transporter signature motif; other site 469383005979 Walker B; other site 469383005980 D-loop; other site 469383005981 H-loop/switch region; other site 469383005982 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383005983 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383005984 Walker A/P-loop; other site 469383005985 ATP binding site [chemical binding]; other site 469383005986 Q-loop/lid; other site 469383005987 ABC transporter signature motif; other site 469383005988 Walker B; other site 469383005989 D-loop; other site 469383005990 H-loop/switch region; other site 469383005991 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 469383005992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383005993 active site 469383005994 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 469383005995 Protein of unknown function (DUF917); Region: DUF917; pfam06032 469383005996 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383005997 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383005998 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383005999 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 469383006000 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383006001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383006002 catalytic residue [active] 469383006003 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 469383006004 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 469383006005 hypothetical protein; Provisional; Region: PRK06446 469383006006 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383006007 metal binding site [ion binding]; metal-binding site 469383006008 GAF domain; Region: GAF_2; pfam13185 469383006009 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383006010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383006011 DNA binding residues [nucleotide binding] 469383006012 dimerization interface [polypeptide binding]; other site 469383006013 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 469383006014 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 469383006015 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 469383006016 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 469383006017 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 469383006018 dimer interface [polypeptide binding]; other site 469383006019 PYR/PP interface [polypeptide binding]; other site 469383006020 TPP binding site [chemical binding]; other site 469383006021 substrate binding site [chemical binding]; other site 469383006022 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 469383006023 TPP-binding site; other site 469383006024 PaaX-like protein; Region: PaaX; pfam07848 469383006025 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 469383006026 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 469383006027 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 469383006028 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383006029 acyl-activating enzyme (AAE) consensus motif; other site 469383006030 AMP binding site [chemical binding]; other site 469383006031 active site 469383006032 CoA binding site [chemical binding]; other site 469383006033 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 469383006034 CoenzymeA binding site [chemical binding]; other site 469383006035 subunit interaction site [polypeptide binding]; other site 469383006036 PHB binding site; other site 469383006037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383006038 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 469383006039 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383006040 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383006041 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383006042 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 469383006043 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383006044 dimer interface [polypeptide binding]; other site 469383006045 active site 469383006046 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383006047 classical (c) SDRs; Region: SDR_c; cd05233 469383006048 NAD(P) binding site [chemical binding]; other site 469383006049 active site 469383006050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006051 enoyl-CoA hydratase; Provisional; Region: PRK06688 469383006052 substrate binding site [chemical binding]; other site 469383006053 oxyanion hole (OAH) forming residues; other site 469383006054 trimer interface [polypeptide binding]; other site 469383006055 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383006056 homotrimer interaction site [polypeptide binding]; other site 469383006057 putative active site [active] 469383006058 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383006059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383006060 active site 469383006061 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 469383006062 hypothetical protein; Provisional; Region: PRK07236 469383006063 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 469383006064 active site 469383006065 FMN binding site [chemical binding]; other site 469383006066 substrate binding site [chemical binding]; other site 469383006067 homotetramer interface [polypeptide binding]; other site 469383006068 catalytic residue [active] 469383006069 enoyl-CoA hydratase; Provisional; Region: PRK05862 469383006070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006071 substrate binding site [chemical binding]; other site 469383006072 oxyanion hole (OAH) forming residues; other site 469383006073 trimer interface [polypeptide binding]; other site 469383006074 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 469383006075 DNA binding site [nucleotide binding] 469383006076 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 469383006077 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383006078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383006079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383006080 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 469383006081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383006082 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 469383006083 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469383006084 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469383006085 ligand binding site [chemical binding]; other site 469383006086 flexible hinge region; other site 469383006087 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 469383006088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383006089 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 469383006090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006091 Walker A/P-loop; other site 469383006092 ATP binding site [chemical binding]; other site 469383006093 Q-loop/lid; other site 469383006094 ABC transporter signature motif; other site 469383006095 Walker B; other site 469383006096 D-loop; other site 469383006097 H-loop/switch region; other site 469383006098 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383006099 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383006100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006101 Walker A/P-loop; other site 469383006102 ATP binding site [chemical binding]; other site 469383006103 Q-loop/lid; other site 469383006104 ABC transporter signature motif; other site 469383006105 Walker B; other site 469383006106 D-loop; other site 469383006107 H-loop/switch region; other site 469383006108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 469383006109 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383006110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006111 dimer interface [polypeptide binding]; other site 469383006112 conserved gate region; other site 469383006113 putative PBP binding loops; other site 469383006114 ABC-ATPase subunit interface; other site 469383006115 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383006116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006117 putative PBP binding loops; other site 469383006118 dimer interface [polypeptide binding]; other site 469383006119 ABC-ATPase subunit interface; other site 469383006120 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383006121 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383006122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383006123 active site 469383006124 diaminopimelate decarboxylase; Region: lysA; TIGR01048 469383006125 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 469383006126 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383006127 catalytic residue [active] 469383006128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383006129 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383006130 active site 469383006131 metal binding site [ion binding]; metal-binding site 469383006132 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 469383006133 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 469383006134 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 469383006135 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469383006136 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383006137 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 469383006138 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 469383006139 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 469383006140 putative active site [active] 469383006141 putative catalytic site [active] 469383006142 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 469383006143 putative active site [active] 469383006144 putative catalytic site [active] 469383006145 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383006146 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 469383006147 putative DNA binding site [nucleotide binding]; other site 469383006148 putative Zn2+ binding site [ion binding]; other site 469383006149 AsnC family; Region: AsnC_trans_reg; pfam01037 469383006150 enoyl-CoA hydratase; Provisional; Region: PRK05862 469383006151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006152 substrate binding site [chemical binding]; other site 469383006153 oxyanion hole (OAH) forming residues; other site 469383006154 trimer interface [polypeptide binding]; other site 469383006155 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 469383006156 enoyl-CoA hydratase; Provisional; Region: PRK08140 469383006157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006158 substrate binding site [chemical binding]; other site 469383006159 oxyanion hole (OAH) forming residues; other site 469383006160 trimer interface [polypeptide binding]; other site 469383006161 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383006162 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 469383006163 acyl-activating enzyme (AAE) consensus motif; other site 469383006164 AMP binding site [chemical binding]; other site 469383006165 active site 469383006166 CoA binding site [chemical binding]; other site 469383006167 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 469383006168 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383006169 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383006170 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383006171 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383006172 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 469383006173 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383006174 TPP-binding site [chemical binding]; other site 469383006175 tetramer interface [polypeptide binding]; other site 469383006176 heterodimer interface [polypeptide binding]; other site 469383006177 phosphorylation loop region [posttranslational modification] 469383006178 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383006179 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383006180 alpha subunit interface [polypeptide binding]; other site 469383006181 TPP binding site [chemical binding]; other site 469383006182 heterodimer interface [polypeptide binding]; other site 469383006183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383006184 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383006185 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383006186 E3 interaction surface; other site 469383006187 lipoyl attachment site [posttranslational modification]; other site 469383006188 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383006189 Fic family protein [Function unknown]; Region: COG3177 469383006190 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 469383006191 Fic/DOC family; Region: Fic; pfam02661 469383006192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006194 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 469383006195 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383006196 dimer interface [polypeptide binding]; other site 469383006197 active site 469383006198 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 469383006199 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383006200 NAD(P) binding site [chemical binding]; other site 469383006201 catalytic residues [active] 469383006202 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 469383006203 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 469383006204 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 469383006205 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 469383006206 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 469383006207 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 469383006208 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 469383006209 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 469383006210 FAD binding pocket [chemical binding]; other site 469383006211 FAD binding motif [chemical binding]; other site 469383006212 phosphate binding motif [ion binding]; other site 469383006213 beta-alpha-beta structure motif; other site 469383006214 NAD(p) ribose binding residues [chemical binding]; other site 469383006215 NAD binding pocket [chemical binding]; other site 469383006216 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 469383006217 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383006218 catalytic loop [active] 469383006219 iron binding site [ion binding]; other site 469383006220 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383006221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383006222 DNA-binding site [nucleotide binding]; DNA binding site 469383006223 FCD domain; Region: FCD; pfam07729 469383006224 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 469383006225 homotrimer interaction site [polypeptide binding]; other site 469383006226 putative active site [active] 469383006227 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383006228 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383006229 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383006230 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383006231 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 469383006232 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383006233 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383006234 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383006235 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383006236 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383006237 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383006238 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383006239 Creatinine amidohydrolase; Region: Creatininase; pfam02633 469383006240 Protein of unknown function (DUF917); Region: DUF917; pfam06032 469383006241 Protein of unknown function (DUF917); Region: DUF917; pfam06032 469383006242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383006243 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383006244 TM-ABC transporter signature motif; other site 469383006245 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383006246 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383006247 Walker A/P-loop; other site 469383006248 ATP binding site [chemical binding]; other site 469383006249 Q-loop/lid; other site 469383006250 ABC transporter signature motif; other site 469383006251 Walker B; other site 469383006252 D-loop; other site 469383006253 H-loop/switch region; other site 469383006254 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383006255 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383006256 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383006257 ligand binding site [chemical binding]; other site 469383006258 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383006259 homotrimer interaction site [polypeptide binding]; other site 469383006260 putative active site [active] 469383006261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006262 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 469383006263 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383006264 intersubunit interface [polypeptide binding]; other site 469383006265 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 469383006266 FAD binding pocket [chemical binding]; other site 469383006267 FAD binding motif [chemical binding]; other site 469383006268 phosphate binding motif [ion binding]; other site 469383006269 NAD binding pocket [chemical binding]; other site 469383006270 MMPL family; Region: MMPL; pfam03176 469383006271 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383006272 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 469383006273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383006274 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383006275 DNA binding residues [nucleotide binding] 469383006276 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 469383006277 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 469383006278 putative active site [active] 469383006279 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 469383006280 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 469383006281 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 469383006282 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 469383006283 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383006284 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383006285 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383006286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006287 dimer interface [polypeptide binding]; other site 469383006288 conserved gate region; other site 469383006289 putative PBP binding loops; other site 469383006290 ABC-ATPase subunit interface; other site 469383006291 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383006292 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 469383006293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006294 dimer interface [polypeptide binding]; other site 469383006295 conserved gate region; other site 469383006296 putative PBP binding loops; other site 469383006297 ABC-ATPase subunit interface; other site 469383006298 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383006299 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006300 Walker A/P-loop; other site 469383006301 ATP binding site [chemical binding]; other site 469383006302 Q-loop/lid; other site 469383006303 ABC transporter signature motif; other site 469383006304 Walker B; other site 469383006305 D-loop; other site 469383006306 H-loop/switch region; other site 469383006307 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 469383006308 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383006309 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006310 Walker A/P-loop; other site 469383006311 ATP binding site [chemical binding]; other site 469383006312 Q-loop/lid; other site 469383006313 ABC transporter signature motif; other site 469383006314 Walker B; other site 469383006315 D-loop; other site 469383006316 H-loop/switch region; other site 469383006317 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383006318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383006319 active site 469383006320 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 469383006321 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 469383006322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006324 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383006325 active site 469383006326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006327 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383006328 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383006329 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383006330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006331 dimer interface [polypeptide binding]; other site 469383006332 conserved gate region; other site 469383006333 putative PBP binding loops; other site 469383006334 ABC-ATPase subunit interface; other site 469383006335 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383006336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006337 dimer interface [polypeptide binding]; other site 469383006338 conserved gate region; other site 469383006339 putative PBP binding loops; other site 469383006340 ABC-ATPase subunit interface; other site 469383006341 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383006342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006343 Walker A/P-loop; other site 469383006344 ATP binding site [chemical binding]; other site 469383006345 Q-loop/lid; other site 469383006346 ABC transporter signature motif; other site 469383006347 Walker B; other site 469383006348 D-loop; other site 469383006349 H-loop/switch region; other site 469383006350 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383006351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383006352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006353 Walker A/P-loop; other site 469383006354 ATP binding site [chemical binding]; other site 469383006355 Q-loop/lid; other site 469383006356 ABC transporter signature motif; other site 469383006357 Walker B; other site 469383006358 D-loop; other site 469383006359 H-loop/switch region; other site 469383006360 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383006361 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383006362 Amidase; Region: Amidase; cl11426 469383006363 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 469383006364 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383006365 acyl-activating enzyme (AAE) consensus motif; other site 469383006366 AMP binding site [chemical binding]; other site 469383006367 active site 469383006368 CoA binding site [chemical binding]; other site 469383006369 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383006370 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 469383006371 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 469383006372 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 469383006373 conserved cys residue [active] 469383006374 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 469383006375 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 469383006376 tetrameric interface [polypeptide binding]; other site 469383006377 NAD binding site [chemical binding]; other site 469383006378 catalytic residues [active] 469383006379 substrate binding site [chemical binding]; other site 469383006380 hypothetical protein; Provisional; Region: PRK06148 469383006381 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383006382 active site 469383006383 ATP binding site [chemical binding]; other site 469383006384 substrate binding site [chemical binding]; other site 469383006385 Peptidase family M23; Region: Peptidase_M23; pfam01551 469383006386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383006387 inhibitor-cofactor binding pocket; inhibition site 469383006388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383006389 catalytic residue [active] 469383006390 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383006391 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 469383006392 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 469383006393 NAD binding site [chemical binding]; other site 469383006394 Phe binding site; other site 469383006395 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 469383006396 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383006397 PYR/PP interface [polypeptide binding]; other site 469383006398 dimer interface [polypeptide binding]; other site 469383006399 TPP binding site [chemical binding]; other site 469383006400 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383006401 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 469383006402 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 469383006403 TPP-binding site [chemical binding]; other site 469383006404 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383006405 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383006406 NAD(P) binding site [chemical binding]; other site 469383006407 catalytic residues [active] 469383006408 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 469383006409 Fe2+ transport protein; Region: Iron_transport; cl01377 469383006410 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 469383006411 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383006412 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 469383006413 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 469383006414 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 469383006415 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 469383006416 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 469383006417 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383006418 putative NAD(P) binding site [chemical binding]; other site 469383006419 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 469383006420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383006421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006422 ABC-ATPase subunit interface; other site 469383006423 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383006424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006425 dimer interface [polypeptide binding]; other site 469383006426 conserved gate region; other site 469383006427 putative PBP binding loops; other site 469383006428 ABC-ATPase subunit interface; other site 469383006429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383006430 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383006431 Walker A/P-loop; other site 469383006432 ATP binding site [chemical binding]; other site 469383006433 Q-loop/lid; other site 469383006434 ABC transporter signature motif; other site 469383006435 Walker B; other site 469383006436 D-loop; other site 469383006437 H-loop/switch region; other site 469383006438 TOBE domain; Region: TOBE_2; pfam08402 469383006439 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 469383006440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383006441 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383006442 homotrimer interaction site [polypeptide binding]; other site 469383006443 putative active site [active] 469383006444 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383006445 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383006446 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383006447 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 469383006448 substrate binding site [chemical binding]; other site 469383006449 metal binding site [ion binding]; metal-binding site 469383006450 dimer interface [polypeptide binding]; other site 469383006451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383006452 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383006453 NAD(P) binding site [chemical binding]; other site 469383006454 active site 469383006455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006457 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 469383006458 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 469383006459 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 469383006460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383006461 AAA ATPase domain; Region: AAA_16; pfam13191 469383006462 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383006463 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383006464 DNA binding residues [nucleotide binding] 469383006465 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383006466 ArsC family; Region: ArsC; pfam03960 469383006467 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 469383006468 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 469383006469 putative active site [active] 469383006470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383006471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383006472 DNA binding residues [nucleotide binding] 469383006473 dimerization interface [polypeptide binding]; other site 469383006474 putative pectinesterase; Region: PLN02432; cl01911 469383006475 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 469383006476 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 469383006477 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 469383006478 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 469383006479 conserved repeat domain; Region: B_ant_repeat; TIGR01451 469383006480 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383006481 conserved repeat domain; Region: B_ant_repeat; TIGR01451 469383006482 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 469383006483 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383006484 MarR family; Region: MarR_2; pfam12802 469383006485 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 469383006486 B12 binding site [chemical binding]; other site 469383006487 cobalt ligand [ion binding]; other site 469383006488 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383006489 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 469383006490 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383006491 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 469383006492 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383006493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383006494 catalytic residue [active] 469383006495 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 469383006496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383006497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383006498 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 469383006499 putative dimerization interface [polypeptide binding]; other site 469383006500 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383006501 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383006502 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383006503 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383006504 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 469383006505 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 469383006506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383006507 inhibitor-cofactor binding pocket; inhibition site 469383006508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383006509 catalytic residue [active] 469383006510 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383006511 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383006512 NAD(P) binding site [chemical binding]; other site 469383006513 catalytic residues [active] 469383006514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383006515 classical (c) SDRs; Region: SDR_c; cd05233 469383006516 NAD(P) binding site [chemical binding]; other site 469383006517 active site 469383006518 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383006519 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383006520 ligand binding site [chemical binding]; other site 469383006521 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383006522 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383006523 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383006524 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383006525 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 469383006526 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383006527 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383006528 Walker A/P-loop; other site 469383006529 ATP binding site [chemical binding]; other site 469383006530 Q-loop/lid; other site 469383006531 ABC transporter signature motif; other site 469383006532 Walker B; other site 469383006533 D-loop; other site 469383006534 H-loop/switch region; other site 469383006535 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383006536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383006537 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383006538 TM-ABC transporter signature motif; other site 469383006539 Uncharacterized conserved protein [Function unknown]; Region: COG5276 469383006540 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 469383006541 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 469383006542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383006543 ATP binding site [chemical binding]; other site 469383006544 Mg2+ binding site [ion binding]; other site 469383006545 G-X-G motif; other site 469383006546 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 469383006547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383006548 active site 469383006549 phosphorylation site [posttranslational modification] 469383006550 intermolecular recognition site; other site 469383006551 dimerization interface [polypeptide binding]; other site 469383006552 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383006553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383006554 DNA-binding site [nucleotide binding]; DNA binding site 469383006555 FCD domain; Region: FCD; pfam07729 469383006556 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383006557 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383006558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383006559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006560 dimer interface [polypeptide binding]; other site 469383006561 conserved gate region; other site 469383006562 putative PBP binding loops; other site 469383006563 ABC-ATPase subunit interface; other site 469383006564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383006565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006566 dimer interface [polypeptide binding]; other site 469383006567 conserved gate region; other site 469383006568 ABC-ATPase subunit interface; other site 469383006569 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383006570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006571 Walker A/P-loop; other site 469383006572 ATP binding site [chemical binding]; other site 469383006573 Q-loop/lid; other site 469383006574 ABC transporter signature motif; other site 469383006575 Walker B; other site 469383006576 D-loop; other site 469383006577 H-loop/switch region; other site 469383006578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383006579 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383006580 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006581 Walker A/P-loop; other site 469383006582 ATP binding site [chemical binding]; other site 469383006583 Q-loop/lid; other site 469383006584 ABC transporter signature motif; other site 469383006585 Walker B; other site 469383006586 D-loop; other site 469383006587 H-loop/switch region; other site 469383006588 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383006589 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 469383006590 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 469383006591 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383006592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383006593 S-adenosylmethionine binding site [chemical binding]; other site 469383006594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 469383006595 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 469383006596 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383006597 NAD(P) binding site [chemical binding]; other site 469383006598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383006599 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 469383006600 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383006601 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383006602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383006603 putative DNA binding site [nucleotide binding]; other site 469383006604 putative Zn2+ binding site [ion binding]; other site 469383006605 Cna protein B-type domain; Region: Cna_B; pfam05738 469383006606 acetylornithine deacetylase; Validated; Region: PRK06915 469383006607 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383006608 metal binding site [ion binding]; metal-binding site 469383006609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383006610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383006611 DNA binding site [nucleotide binding] 469383006612 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383006613 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383006614 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383006615 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383006616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006617 Walker A/P-loop; other site 469383006618 ATP binding site [chemical binding]; other site 469383006619 Q-loop/lid; other site 469383006620 ABC transporter signature motif; other site 469383006621 Walker B; other site 469383006622 D-loop; other site 469383006623 H-loop/switch region; other site 469383006624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 469383006625 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 469383006626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383006627 Walker A/P-loop; other site 469383006628 ATP binding site [chemical binding]; other site 469383006629 Q-loop/lid; other site 469383006630 ABC transporter signature motif; other site 469383006631 Walker B; other site 469383006632 D-loop; other site 469383006633 H-loop/switch region; other site 469383006634 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383006635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006636 dimer interface [polypeptide binding]; other site 469383006637 conserved gate region; other site 469383006638 ABC-ATPase subunit interface; other site 469383006639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383006640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 469383006641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383006642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006643 dimer interface [polypeptide binding]; other site 469383006644 ABC-ATPase subunit interface; other site 469383006645 putative PBP binding loops; other site 469383006646 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383006647 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383006648 Amidase; Region: Amidase; cl11426 469383006649 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383006650 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 469383006651 active site 469383006652 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 469383006653 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383006654 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 469383006655 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383006656 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 469383006657 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383006658 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383006659 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 469383006660 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006661 substrate binding site [chemical binding]; other site 469383006662 oxyanion hole (OAH) forming residues; other site 469383006663 trimer interface [polypeptide binding]; other site 469383006664 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 469383006665 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383006666 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 469383006667 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383006668 acyl-activating enzyme (AAE) consensus motif; other site 469383006669 AMP binding site [chemical binding]; other site 469383006670 active site 469383006671 CoA binding site [chemical binding]; other site 469383006672 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469383006673 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383006674 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 469383006675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006676 substrate binding site [chemical binding]; other site 469383006677 oxyanion hole (OAH) forming residues; other site 469383006678 trimer interface [polypeptide binding]; other site 469383006679 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383006680 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383006681 active site 469383006682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383006683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383006684 NAD(P) binding site [chemical binding]; other site 469383006685 active site 469383006686 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 469383006687 Chromate transporter; Region: Chromate_transp; pfam02417 469383006688 Chromate transporter; Region: Chromate_transp; pfam02417 469383006689 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383006690 ligand binding site [chemical binding]; other site 469383006691 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383006692 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383006693 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383006694 Walker A/P-loop; other site 469383006695 ATP binding site [chemical binding]; other site 469383006696 Q-loop/lid; other site 469383006697 ABC transporter signature motif; other site 469383006698 Walker B; other site 469383006699 D-loop; other site 469383006700 H-loop/switch region; other site 469383006701 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383006702 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383006703 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383006704 TM-ABC transporter signature motif; other site 469383006705 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 469383006706 enoyl-CoA hydratase; Region: PLN02864 469383006707 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 469383006708 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 469383006709 active site 2 [active] 469383006710 active site 1 [active] 469383006711 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 469383006712 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383006713 dimer interface [polypeptide binding]; other site 469383006714 active site 469383006715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006717 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 469383006718 enoyl-CoA hydratase; Provisional; Region: PRK08290 469383006719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006720 substrate binding site [chemical binding]; other site 469383006721 oxyanion hole (OAH) forming residues; other site 469383006722 trimer interface [polypeptide binding]; other site 469383006723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383006724 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383006725 active site 469383006726 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383006727 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383006728 active site 469383006729 enoyl-CoA hydratase; Provisional; Region: PRK06495 469383006730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383006731 substrate binding site [chemical binding]; other site 469383006732 oxyanion hole (OAH) forming residues; other site 469383006733 trimer interface [polypeptide binding]; other site 469383006734 short chain dehydrogenase; Provisional; Region: PRK07831 469383006735 classical (c) SDRs; Region: SDR_c; cd05233 469383006736 NAD(P) binding site [chemical binding]; other site 469383006737 active site 469383006738 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 469383006739 Coenzyme A transferase; Region: CoA_trans; cl17247 469383006740 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 469383006741 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 469383006742 FMN binding site [chemical binding]; other site 469383006743 substrate binding site [chemical binding]; other site 469383006744 putative catalytic residue [active] 469383006745 short chain dehydrogenase; Provisional; Region: PRK07791 469383006746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383006747 NAD(P) binding site [chemical binding]; other site 469383006748 active site 469383006749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006751 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 469383006752 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383006753 dimer interface [polypeptide binding]; other site 469383006754 active site 469383006755 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 469383006756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383006757 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 469383006758 acyl-activating enzyme (AAE) consensus motif; other site 469383006759 acyl-activating enzyme (AAE) consensus motif; other site 469383006760 putative AMP binding site [chemical binding]; other site 469383006761 putative active site [active] 469383006762 putative CoA binding site [chemical binding]; other site 469383006763 CoA binding site [chemical binding]; other site 469383006764 Putative cyclase; Region: Cyclase; pfam04199 469383006765 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383006766 ligand binding site [chemical binding]; other site 469383006767 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383006768 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383006769 Sulfatase; Region: Sulfatase; pfam00884 469383006770 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383006771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383006772 sequence-specific DNA binding site [nucleotide binding]; other site 469383006773 salt bridge; other site 469383006774 Cupin domain; Region: Cupin_2; cl17218 469383006775 Htaa; Region: HtaA; pfam04213 469383006776 Immunoglobulin I-set domain; Region: I-set; pfam07679 469383006777 Immunoglobulin like; Region: IG_like; smart00410 469383006778 Htaa; Region: HtaA; pfam04213 469383006779 Muconolactone delta-isomerase; Region: MIase; cl01992 469383006780 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 469383006781 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 469383006782 catalytic residues [active] 469383006783 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 469383006784 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383006785 NAD(P) binding site [chemical binding]; other site 469383006786 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383006787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006789 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469383006790 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 469383006791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383006792 Walker A/P-loop; other site 469383006793 ATP binding site [chemical binding]; other site 469383006794 Q-loop/lid; other site 469383006795 ABC transporter signature motif; other site 469383006796 Walker B; other site 469383006797 D-loop; other site 469383006798 H-loop/switch region; other site 469383006799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383006800 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 469383006801 Walker A/P-loop; other site 469383006802 ATP binding site [chemical binding]; other site 469383006803 Q-loop/lid; other site 469383006804 ABC transporter signature motif; other site 469383006805 Walker B; other site 469383006806 D-loop; other site 469383006807 H-loop/switch region; other site 469383006808 Fic family protein [Function unknown]; Region: COG3177 469383006809 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 469383006810 Fic/DOC family; Region: Fic; pfam02661 469383006811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 469383006812 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 469383006813 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 469383006814 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383006815 intersubunit interface [polypeptide binding]; other site 469383006816 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 469383006817 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383006818 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 469383006819 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 469383006820 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 469383006821 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 469383006822 ABC-ATPase subunit interface; other site 469383006823 dimer interface [polypeptide binding]; other site 469383006824 putative PBP binding regions; other site 469383006825 Ferredoxin [Energy production and conversion]; Region: COG1146 469383006826 4Fe-4S binding domain; Region: Fer4; cl02805 469383006827 ferredoxin-NADP+ reductase; Region: PLN02852 469383006828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383006829 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 469383006830 RibD C-terminal domain; Region: RibD_C; cl17279 469383006831 Family description; Region: VCBS; pfam13517 469383006832 Family description; Region: VCBS; pfam13517 469383006833 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383006834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383006835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383006836 active site 469383006837 phosphorylation site [posttranslational modification] 469383006838 intermolecular recognition site; other site 469383006839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383006840 DNA binding residues [nucleotide binding] 469383006841 dimerization interface [polypeptide binding]; other site 469383006842 MMPL family; Region: MMPL; pfam03176 469383006843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006845 WHG domain; Region: WHG; pfam13305 469383006846 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383006847 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383006848 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 469383006849 NAD(P) binding site [chemical binding]; other site 469383006850 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383006851 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383006852 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383006853 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 469383006854 putative active site [active] 469383006855 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 469383006856 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 469383006857 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 469383006858 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383006859 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 469383006860 DNA binding residues [nucleotide binding] 469383006861 META domain; Region: META; pfam03724 469383006862 META domain; Region: META; pfam03724 469383006863 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383006864 FAD binding domain; Region: FAD_binding_4; pfam01565 469383006865 Berberine and berberine like; Region: BBE; pfam08031 469383006866 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383006867 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383006868 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383006869 Sulfatase; Region: Sulfatase; pfam00884 469383006870 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383006871 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383006872 FAD binding domain; Region: FAD_binding_4; pfam01565 469383006873 Berberine and berberine like; Region: BBE; pfam08031 469383006874 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 469383006875 Predicted ATPase [General function prediction only]; Region: COG3903 469383006876 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 469383006877 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 469383006878 Family description; Region: VCBS; pfam13517 469383006879 Family description; Region: VCBS; pfam13517 469383006880 Family description; Region: VCBS; pfam13517 469383006881 AAA ATPase domain; Region: AAA_16; pfam13191 469383006882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383006883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383006884 DNA binding residues [nucleotide binding] 469383006885 dimerization interface [polypeptide binding]; other site 469383006886 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383006887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383006888 DNA-binding site [nucleotide binding]; DNA binding site 469383006889 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383006890 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 469383006891 hypothetical protein; Provisional; Region: PRK11171 469383006892 Cupin domain; Region: Cupin_2; pfam07883 469383006893 Cupin domain; Region: Cupin_2; pfam07883 469383006894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006895 dimer interface [polypeptide binding]; other site 469383006896 conserved gate region; other site 469383006897 putative PBP binding loops; other site 469383006898 ABC-ATPase subunit interface; other site 469383006899 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383006900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006901 dimer interface [polypeptide binding]; other site 469383006902 conserved gate region; other site 469383006903 putative PBP binding loops; other site 469383006904 ABC-ATPase subunit interface; other site 469383006905 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 469383006906 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383006907 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383006908 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383006909 active site 469383006910 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383006911 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 469383006912 active site 469383006913 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383006914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383006915 Walker A/P-loop; other site 469383006916 ATP binding site [chemical binding]; other site 469383006917 Q-loop/lid; other site 469383006918 ABC transporter signature motif; other site 469383006919 Walker B; other site 469383006920 D-loop; other site 469383006921 H-loop/switch region; other site 469383006922 TOBE domain; Region: TOBE_2; pfam08402 469383006923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 469383006924 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 469383006925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383006926 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383006927 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383006928 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 469383006929 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 469383006930 active site residue [active] 469383006931 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383006932 FAD binding domain; Region: FAD_binding_4; pfam01565 469383006933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 469383006934 substrate binding pocket [chemical binding]; other site 469383006935 membrane-bound complex binding site; other site 469383006936 hinge residues; other site 469383006937 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383006938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006939 dimer interface [polypeptide binding]; other site 469383006940 conserved gate region; other site 469383006941 ABC-ATPase subunit interface; other site 469383006942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383006943 dimer interface [polypeptide binding]; other site 469383006944 conserved gate region; other site 469383006945 putative PBP binding loops; other site 469383006946 ABC-ATPase subunit interface; other site 469383006947 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383006948 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383006949 Walker A/P-loop; other site 469383006950 ATP binding site [chemical binding]; other site 469383006951 Q-loop/lid; other site 469383006952 ABC transporter signature motif; other site 469383006953 Walker B; other site 469383006954 D-loop; other site 469383006955 H-loop/switch region; other site 469383006956 YceI-like domain; Region: YceI; pfam04264 469383006957 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 469383006958 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383006959 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 469383006960 intersubunit interface [polypeptide binding]; other site 469383006961 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 469383006962 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 469383006963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383006964 sequence-specific DNA binding site [nucleotide binding]; other site 469383006965 salt bridge; other site 469383006966 Cupin domain; Region: Cupin_2; pfam07883 469383006967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 469383006968 MOSC domain; Region: MOSC; pfam03473 469383006969 3-alpha domain; Region: 3-alpha; pfam03475 469383006970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383006971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383006972 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 469383006973 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383006974 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 469383006975 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 469383006976 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 469383006977 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 469383006978 acyl-activating enzyme (AAE) consensus motif; other site 469383006979 AMP binding site [chemical binding]; other site 469383006980 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 469383006981 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 469383006982 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 469383006983 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383006984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383006985 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383006986 S-adenosylmethionine binding site [chemical binding]; other site 469383006987 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 469383006988 acyl-activating enzyme (AAE) consensus motif; other site 469383006989 AMP binding site [chemical binding]; other site 469383006990 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 469383006991 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 469383006992 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 469383006993 nucleoside/Zn binding site; other site 469383006994 dimer interface [polypeptide binding]; other site 469383006995 catalytic motif [active] 469383006996 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 469383006997 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 469383006998 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 469383006999 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 469383007000 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 469383007001 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 469383007002 pyruvate carboxylase; Reviewed; Region: PRK12999 469383007003 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 469383007004 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383007005 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 469383007006 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 469383007007 active site 469383007008 catalytic residues [active] 469383007009 metal binding site [ion binding]; metal-binding site 469383007010 homodimer binding site [polypeptide binding]; other site 469383007011 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 469383007012 carboxyltransferase (CT) interaction site; other site 469383007013 biotinylation site [posttranslational modification]; other site 469383007014 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383007015 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383007016 metal binding site [ion binding]; metal-binding site 469383007017 active site 469383007018 I-site; other site 469383007019 BclB C-terminal domain; Region: exospore_TM; TIGR03721 469383007020 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 469383007021 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383007022 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383007023 Hemerythrin-like domain; Region: Hr-like; cd12108 469383007024 RNA polymerase factor sigma-70; Validated; Region: PRK08241 469383007025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383007026 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383007027 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 469383007028 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 469383007029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383007030 putative substrate translocation pore; other site 469383007031 YCII-related domain; Region: YCII; cl00999 469383007032 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383007033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383007034 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383007035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383007036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383007037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383007038 dimerization interface [polypeptide binding]; other site 469383007039 DNA binding residues [nucleotide binding] 469383007040 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383007041 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383007042 Walker A/P-loop; other site 469383007043 ATP binding site [chemical binding]; other site 469383007044 Q-loop/lid; other site 469383007045 ABC transporter signature motif; other site 469383007046 Walker B; other site 469383007047 D-loop; other site 469383007048 H-loop/switch region; other site 469383007049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383007050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383007051 active site 469383007052 phosphorylation site [posttranslational modification] 469383007053 intermolecular recognition site; other site 469383007054 dimerization interface [polypeptide binding]; other site 469383007055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383007056 dimerization interface [polypeptide binding]; other site 469383007057 DNA binding residues [nucleotide binding] 469383007058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383007059 Histidine kinase; Region: HisKA_3; pfam07730 469383007060 conserved repeat domain; Region: B_ant_repeat; TIGR01451 469383007061 Domain of unknown function DUF11; Region: DUF11; cl17728 469383007062 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383007063 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383007064 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383007065 Domain of unknown function DUF11; Region: DUF11; cl17728 469383007066 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383007067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383007068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383007069 dimerization interface [polypeptide binding]; other site 469383007070 putative DNA binding site [nucleotide binding]; other site 469383007071 putative Zn2+ binding site [ion binding]; other site 469383007072 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 469383007073 hydrophobic ligand binding site; other site 469383007074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383007075 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383007076 active site 469383007077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 469383007078 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 469383007079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 469383007080 metal-binding site [ion binding] 469383007081 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 469383007082 Penicillinase repressor; Region: Pencillinase_R; cl17580 469383007083 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 469383007084 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 469383007085 catalytic residues [active] 469383007086 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 469383007087 putative active site [active] 469383007088 redox center [active] 469383007089 RNA polymerase factor sigma-70; Validated; Region: PRK08241 469383007090 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383007091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383007092 DNA binding residues [nucleotide binding] 469383007093 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383007094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383007095 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 469383007096 OsmC-like protein; Region: OsmC; pfam02566 469383007097 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 469383007098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383007099 DNA-binding site [nucleotide binding]; DNA binding site 469383007100 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383007101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383007102 catalytic residue [active] 469383007103 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 469383007104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 469383007105 Predicted acyl esterases [General function prediction only]; Region: COG2936 469383007106 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383007107 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383007108 classical (c) SDRs; Region: SDR_c; cd05233 469383007109 NAD(P) binding site [chemical binding]; other site 469383007110 active site 469383007111 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469383007112 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383007113 Coenzyme A transferase; Region: CoA_trans; cl17247 469383007114 Coenzyme A transferase; Region: CoA_trans; cl17247 469383007115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383007116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383007117 DNA binding site [nucleotide binding] 469383007118 domain linker motif; other site 469383007119 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383007120 ligand binding site [chemical binding]; other site 469383007121 dimerization interface [polypeptide binding]; other site 469383007122 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383007123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383007124 DNA-binding site [nucleotide binding]; DNA binding site 469383007125 FCD domain; Region: FCD; pfam07729 469383007126 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383007127 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 469383007128 substrate binding site [chemical binding]; other site 469383007129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383007130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383007131 dimer interface [polypeptide binding]; other site 469383007132 conserved gate region; other site 469383007133 putative PBP binding loops; other site 469383007134 ABC-ATPase subunit interface; other site 469383007135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383007136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 469383007137 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383007138 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383007139 Walker A/P-loop; other site 469383007140 ATP binding site [chemical binding]; other site 469383007141 Q-loop/lid; other site 469383007142 ABC transporter signature motif; other site 469383007143 Walker B; other site 469383007144 D-loop; other site 469383007145 H-loop/switch region; other site 469383007146 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 469383007147 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383007148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383007149 Walker A/P-loop; other site 469383007150 ATP binding site [chemical binding]; other site 469383007151 Q-loop/lid; other site 469383007152 ABC transporter signature motif; other site 469383007153 Walker B; other site 469383007154 D-loop; other site 469383007155 H-loop/switch region; other site 469383007156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383007157 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 469383007158 mannonate dehydratase; Region: uxuA; TIGR00695 469383007159 YCII-related domain; Region: YCII; cl00999 469383007160 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 469383007161 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383007162 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 469383007163 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 469383007164 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 469383007165 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 469383007166 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 469383007167 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 469383007168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383007169 motif II; other site 469383007170 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 469383007171 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 469383007172 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 469383007173 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383007174 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383007175 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 469383007176 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 469383007177 dimer interface [polypeptide binding]; other site 469383007178 putative anticodon binding site; other site 469383007179 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 469383007180 motif 1; other site 469383007181 active site 469383007182 motif 2; other site 469383007183 motif 3; other site 469383007184 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 469383007185 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 469383007186 amino acid transporter; Region: 2A0306; TIGR00909 469383007187 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 469383007188 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469383007189 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 469383007190 active site 469383007191 nucleophile elbow; other site 469383007192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383007193 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 469383007194 putative NAD(P) binding site [chemical binding]; other site 469383007195 active site 469383007196 putative substrate binding site [chemical binding]; other site 469383007197 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 469383007198 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 469383007199 glutaminase active site [active] 469383007200 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469383007201 dimer interface [polypeptide binding]; other site 469383007202 active site 469383007203 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 469383007204 dimer interface [polypeptide binding]; other site 469383007205 active site 469383007206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383007207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383007208 active site 469383007209 phosphorylation site [posttranslational modification] 469383007210 intermolecular recognition site; other site 469383007211 dimerization interface [polypeptide binding]; other site 469383007212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383007213 DNA binding residues [nucleotide binding] 469383007214 dimerization interface [polypeptide binding]; other site 469383007215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383007216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383007217 active site 469383007218 phosphorylation site [posttranslational modification] 469383007219 intermolecular recognition site; other site 469383007220 dimerization interface [polypeptide binding]; other site 469383007221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383007222 DNA binding residues [nucleotide binding] 469383007223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383007224 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383007225 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383007226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383007227 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 469383007228 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 469383007229 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383007230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383007231 DNA-binding site [nucleotide binding]; DNA binding site 469383007232 HupF/HypC family; Region: HupF_HypC; cl00394 469383007233 HupF/HypC family; Region: HupF_HypC; cl00394 469383007234 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 469383007235 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 469383007236 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 469383007237 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 469383007238 dimerization interface [polypeptide binding]; other site 469383007239 ATP binding site [chemical binding]; other site 469383007240 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 469383007241 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 469383007242 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 469383007243 NifU-like domain; Region: NifU; cl00484 469383007244 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 469383007245 nickel binding site [ion binding]; other site 469383007246 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 469383007247 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383007248 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469383007249 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 469383007250 dimer interface [polypeptide binding]; other site 469383007251 active site 469383007252 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 469383007253 Acylphosphatase; Region: Acylphosphatase; pfam00708 469383007254 HypF finger; Region: zf-HYPF; pfam07503 469383007255 HypF finger; Region: zf-HYPF; pfam07503 469383007256 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 469383007257 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383007258 putative hydrophobic ligand binding site [chemical binding]; other site 469383007259 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383007260 putative hydrophobic ligand binding site [chemical binding]; other site 469383007261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383007262 dimerization interface [polypeptide binding]; other site 469383007263 putative DNA binding site [nucleotide binding]; other site 469383007264 putative Zn2+ binding site [ion binding]; other site 469383007265 short chain dehydrogenase; Provisional; Region: PRK08278 469383007266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383007267 NAD(P) binding site [chemical binding]; other site 469383007268 active site 469383007269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383007270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383007271 DNA binding site [nucleotide binding] 469383007272 domain linker motif; other site 469383007273 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383007274 dimerization interface [polypeptide binding]; other site 469383007275 ligand binding site [chemical binding]; other site 469383007276 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383007277 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 469383007278 active site 469383007279 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 469383007280 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 469383007281 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 469383007282 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 469383007283 homodimer interface [polypeptide binding]; other site 469383007284 homotetramer interface [polypeptide binding]; other site 469383007285 active site pocket [active] 469383007286 cleavage site 469383007287 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 469383007288 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 469383007289 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 469383007290 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 469383007291 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383007292 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 469383007293 molybdopterin cofactor binding site; other site 469383007294 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383007295 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 469383007296 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 469383007297 putative molybdopterin cofactor binding site; other site 469383007298 Uncharacterized conserved protein [Function unknown]; Region: COG3391 469383007299 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 469383007300 Uncharacterized conserved protein [Function unknown]; Region: COG3391 469383007301 FOG: WD40 repeat [General function prediction only]; Region: COG2319 469383007302 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 469383007303 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 469383007304 putative catalytic site [active] 469383007305 putative phosphate binding site [ion binding]; other site 469383007306 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 469383007307 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 469383007308 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 469383007309 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 469383007310 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383007311 Zn2+ binding site [ion binding]; other site 469383007312 Mg2+ binding site [ion binding]; other site 469383007313 short chain dehydrogenase; Provisional; Region: PRK06523 469383007314 classical (c) SDRs; Region: SDR_c; cd05233 469383007315 NAD(P) binding site [chemical binding]; other site 469383007316 active site 469383007317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383007318 non-specific DNA binding site [nucleotide binding]; other site 469383007319 salt bridge; other site 469383007320 sequence-specific DNA binding site [nucleotide binding]; other site 469383007321 Cupin domain; Region: Cupin_2; pfam07883 469383007322 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 469383007323 agmatinase; Region: agmatinase; TIGR01230 469383007324 oligomer interface [polypeptide binding]; other site 469383007325 putative active site [active] 469383007326 Mn binding site [ion binding]; other site 469383007327 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 469383007328 amidase; Provisional; Region: PRK07869 469383007329 Amidase; Region: Amidase; cl11426 469383007330 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383007331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383007332 active site 469383007333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383007334 Coenzyme A binding pocket [chemical binding]; other site 469383007335 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383007336 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 469383007337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 469383007338 DNA binding residues [nucleotide binding] 469383007339 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 469383007340 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 469383007341 FAD binding pocket [chemical binding]; other site 469383007342 FAD binding motif [chemical binding]; other site 469383007343 phosphate binding motif [ion binding]; other site 469383007344 NAD binding pocket [chemical binding]; other site 469383007345 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383007346 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 469383007347 intersubunit interface [polypeptide binding]; other site 469383007348 hypothetical protein; Provisional; Region: PRK06541 469383007349 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383007350 inhibitor-cofactor binding pocket; inhibition site 469383007351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383007352 catalytic residue [active] 469383007353 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 469383007354 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 469383007355 tetrameric interface [polypeptide binding]; other site 469383007356 NAD binding site [chemical binding]; other site 469383007357 catalytic residues [active] 469383007358 substrate binding site [chemical binding]; other site 469383007359 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 469383007360 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 469383007361 AsnC family; Region: AsnC_trans_reg; pfam01037 469383007362 AAA domain; Region: AAA_14; pfam13173 469383007363 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 469383007364 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 469383007365 Phage Tail Collar Domain; Region: Collar; pfam07484 469383007366 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 469383007367 Phage Tail Collar Domain; Region: Collar; pfam07484 469383007368 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 469383007369 Phage Tail Collar Domain; Region: Collar; pfam07484 469383007370 AAA ATPase domain; Region: AAA_16; pfam13191 469383007371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383007372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383007373 DNA binding residues [nucleotide binding] 469383007374 dimerization interface [polypeptide binding]; other site 469383007375 Right handed beta helix region; Region: Beta_helix; pfam13229 469383007376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383007377 Phosphotransferase enzyme family; Region: APH; pfam01636 469383007378 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 469383007379 substrate binding site [chemical binding]; other site 469383007380 Protein of unknown function, DUF488; Region: DUF488; pfam04343 469383007381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383007382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383007383 Coenzyme A binding pocket [chemical binding]; other site 469383007384 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383007385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383007386 S-adenosylmethionine binding site [chemical binding]; other site 469383007387 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 469383007388 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 469383007389 transmembrane helices; other site 469383007390 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 469383007391 hydroxyglutarate oxidase; Provisional; Region: PRK11728 469383007392 Predicted dehydrogenase [General function prediction only]; Region: COG0579 469383007393 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 469383007394 Moco binding site; other site 469383007395 metal coordination site [ion binding]; other site 469383007396 dimerization interface [polypeptide binding]; other site 469383007397 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383007398 FAD binding domain; Region: FAD_binding_4; pfam01565 469383007399 Berberine and berberine like; Region: BBE; pfam08031 469383007400 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 469383007401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 469383007402 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383007403 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383007404 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 469383007405 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383007406 inhibitor-cofactor binding pocket; inhibition site 469383007407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383007408 catalytic residue [active] 469383007409 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383007410 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383007411 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383007412 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383007413 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 469383007414 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383007415 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383007416 NAD(P) binding site [chemical binding]; other site 469383007417 catalytic residues [active] 469383007418 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 469383007419 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 469383007420 ligand binding site [chemical binding]; other site 469383007421 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383007422 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383007423 Walker A/P-loop; other site 469383007424 ATP binding site [chemical binding]; other site 469383007425 Q-loop/lid; other site 469383007426 ABC transporter signature motif; other site 469383007427 Walker B; other site 469383007428 D-loop; other site 469383007429 H-loop/switch region; other site 469383007430 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383007431 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383007432 Walker A/P-loop; other site 469383007433 ATP binding site [chemical binding]; other site 469383007434 Q-loop/lid; other site 469383007435 ABC transporter signature motif; other site 469383007436 Walker B; other site 469383007437 D-loop; other site 469383007438 H-loop/switch region; other site 469383007439 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383007440 TM-ABC transporter signature motif; other site 469383007441 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383007442 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383007443 TM-ABC transporter signature motif; other site 469383007444 Cupin domain; Region: Cupin_2; cl17218 469383007445 Protein of unknown function (DUF328); Region: DUF328; cl01143 469383007446 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383007447 Cytochrome P450; Region: p450; cl12078 469383007448 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 469383007449 active site clefts [active] 469383007450 zinc binding site [ion binding]; other site 469383007451 dimer interface [polypeptide binding]; other site 469383007452 trigger factor; Provisional; Region: tig; PRK01490 469383007453 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 469383007454 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 469383007455 Clp protease; Region: CLP_protease; pfam00574 469383007456 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 469383007457 oligomer interface [polypeptide binding]; other site 469383007458 active site residues [active] 469383007459 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 469383007460 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 469383007461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383007462 Walker A motif; other site 469383007463 ATP binding site [chemical binding]; other site 469383007464 Walker B motif; other site 469383007465 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 469383007466 orc1/cdc6 family replication initiation protein; Region: TIGR02928 469383007467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383007468 non-specific DNA binding site [nucleotide binding]; other site 469383007469 salt bridge; other site 469383007470 sequence-specific DNA binding site [nucleotide binding]; other site 469383007471 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 469383007472 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383007473 active site 469383007474 HIGH motif; other site 469383007475 nucleotide binding site [chemical binding]; other site 469383007476 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 469383007477 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 469383007478 active site 469383007479 KMSKS motif; other site 469383007480 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 469383007481 tRNA binding surface [nucleotide binding]; other site 469383007482 anticodon binding site; other site 469383007483 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 469383007484 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 469383007485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469383007486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469383007487 Double zinc ribbon; Region: DZR; pfam12773 469383007488 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 469383007489 active site 469383007490 multimer interface [polypeptide binding]; other site 469383007491 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 469383007492 active site 469383007493 dimer interface [polypeptide binding]; other site 469383007494 rod shape-determining protein MreB; Provisional; Region: PRK13927 469383007495 MreB and similar proteins; Region: MreB_like; cd10225 469383007496 nucleotide binding site [chemical binding]; other site 469383007497 Mg binding site [ion binding]; other site 469383007498 putative protofilament interaction site [polypeptide binding]; other site 469383007499 RodZ interaction site [polypeptide binding]; other site 469383007500 rod shape-determining protein MreC; Provisional; Region: PRK13922 469383007501 rod shape-determining protein MreC; Region: MreC; pfam04085 469383007502 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 469383007503 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469383007504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469383007505 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 469383007506 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 469383007507 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 469383007508 homodimer interface [polypeptide binding]; other site 469383007509 oligonucleotide binding site [chemical binding]; other site 469383007510 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 469383007511 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 469383007512 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 469383007513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383007514 NAD(P) binding site [chemical binding]; other site 469383007515 active site 469383007516 GTPase CgtA; Reviewed; Region: obgE; PRK12297 469383007517 GTP1/OBG; Region: GTP1_OBG; pfam01018 469383007518 Obg GTPase; Region: Obg; cd01898 469383007519 G1 box; other site 469383007520 GTP/Mg2+ binding site [chemical binding]; other site 469383007521 Switch I region; other site 469383007522 G2 box; other site 469383007523 G3 box; other site 469383007524 Switch II region; other site 469383007525 G4 box; other site 469383007526 G5 box; other site 469383007527 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 469383007528 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 469383007529 active site 469383007530 Mn binding site [ion binding]; other site 469383007531 gamma-glutamyl kinase; Provisional; Region: PRK05429 469383007532 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 469383007533 nucleotide binding site [chemical binding]; other site 469383007534 homotetrameric interface [polypeptide binding]; other site 469383007535 putative phosphate binding site [ion binding]; other site 469383007536 putative allosteric binding site; other site 469383007537 PUA domain; Region: PUA; pfam01472 469383007538 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 469383007539 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383007540 PYR/PP interface [polypeptide binding]; other site 469383007541 dimer interface [polypeptide binding]; other site 469383007542 TPP binding site [chemical binding]; other site 469383007543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383007544 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 469383007545 TPP-binding site [chemical binding]; other site 469383007546 dimer interface [polypeptide binding]; other site 469383007547 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 469383007548 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 469383007549 putative catalytic cysteine [active] 469383007550 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 469383007551 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 469383007552 active site 469383007553 (T/H)XGH motif; other site 469383007554 Oligomerisation domain; Region: Oligomerisation; pfam02410 469383007555 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 469383007556 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 469383007557 acyl-activating enzyme (AAE) consensus motif; other site 469383007558 putative AMP binding site [chemical binding]; other site 469383007559 putative active site [active] 469383007560 putative CoA binding site [chemical binding]; other site 469383007561 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 469383007562 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 469383007563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383007564 active site 469383007565 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383007566 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 469383007567 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 469383007568 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 469383007569 dimer interface [polypeptide binding]; other site 469383007570 active site 469383007571 non-prolyl cis peptide bond; other site 469383007572 insertion regions; other site 469383007573 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 469383007574 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383007575 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 469383007576 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383007577 Walker A/P-loop; other site 469383007578 ATP binding site [chemical binding]; other site 469383007579 Q-loop/lid; other site 469383007580 ABC transporter signature motif; other site 469383007581 Walker B; other site 469383007582 D-loop; other site 469383007583 H-loop/switch region; other site 469383007584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383007585 ABC transporter signature motif; other site 469383007586 Walker B; other site 469383007587 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383007588 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 469383007589 active site 469383007590 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603 469383007591 TM-ABC transporter signature motif; other site 469383007592 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 469383007593 TM-ABC transporter signature motif; other site 469383007594 Cupin domain; Region: Cupin_2; pfam07883 469383007595 Tim44-like domain; Region: Tim44; cl09208 469383007596 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 469383007597 cleavage site 469383007598 active site 469383007599 substrate binding sites [chemical binding]; other site 469383007600 Domain of unknown function DUF11; Region: DUF11; cl17728 469383007601 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383007602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 469383007603 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 469383007604 ABC-ATPase subunit interface; other site 469383007605 dimer interface [polypeptide binding]; other site 469383007606 putative PBP binding regions; other site 469383007607 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 469383007608 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 469383007609 Walker A/P-loop; other site 469383007610 ATP binding site [chemical binding]; other site 469383007611 Q-loop/lid; other site 469383007612 ABC transporter signature motif; other site 469383007613 Walker B; other site 469383007614 D-loop; other site 469383007615 H-loop/switch region; other site 469383007616 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383007617 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 469383007618 intersubunit interface [polypeptide binding]; other site 469383007619 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 469383007620 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 469383007621 FAD binding pocket [chemical binding]; other site 469383007622 FAD binding motif [chemical binding]; other site 469383007623 phosphate binding motif [ion binding]; other site 469383007624 NAD binding pocket [chemical binding]; other site 469383007625 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 469383007626 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 469383007627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383007628 active site 469383007629 enoyl-CoA hydratase; Provisional; Region: PRK12478 469383007630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383007631 substrate binding site [chemical binding]; other site 469383007632 oxyanion hole (OAH) forming residues; other site 469383007633 trimer interface [polypeptide binding]; other site 469383007634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383007635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383007636 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 469383007637 hydrophobic ligand binding site; other site 469383007638 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383007639 MarR family; Region: MarR_2; cl17246 469383007640 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 469383007641 active site 469383007642 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 469383007643 enoyl-CoA hydratase; Provisional; Region: PRK12478 469383007644 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383007645 substrate binding site [chemical binding]; other site 469383007646 oxyanion hole (OAH) forming residues; other site 469383007647 trimer interface [polypeptide binding]; other site 469383007648 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 469383007649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383007650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383007651 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383007652 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383007653 RNA polymerase factor sigma-70; Validated; Region: PRK08241 469383007654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383007655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383007656 DNA binding residues [nucleotide binding] 469383007657 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383007658 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 469383007659 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 469383007660 homodimer interface [polypeptide binding]; other site 469383007661 active site 469383007662 TDP-binding site; other site 469383007663 acceptor substrate-binding pocket; other site 469383007664 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 469383007665 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 469383007666 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 469383007667 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 469383007668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383007669 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383007670 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 469383007671 Cl- selectivity filter; other site 469383007672 Cl- binding residues [ion binding]; other site 469383007673 pore gating glutamate residue; other site 469383007674 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 469383007675 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 469383007676 nucleotide binding site [chemical binding]; other site 469383007677 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 469383007678 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 469383007679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383007680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383007681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 469383007682 dimerization interface [polypeptide binding]; other site 469383007683 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 469383007684 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 469383007685 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 469383007686 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 469383007687 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 469383007688 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 469383007689 Protein of unknown function DUF91; Region: DUF91; cl00709 469383007690 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 469383007691 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 469383007692 heme binding site [chemical binding]; other site 469383007693 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 469383007694 ferric uptake regulator; Provisional; Region: fur; PRK09462 469383007695 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 469383007696 metal binding site 2 [ion binding]; metal-binding site 469383007697 putative DNA binding helix; other site 469383007698 metal binding site 1 [ion binding]; metal-binding site 469383007699 dimer interface [polypeptide binding]; other site 469383007700 structural Zn2+ binding site [ion binding]; other site 469383007701 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 469383007702 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 469383007703 active site 469383007704 NAD binding site [chemical binding]; other site 469383007705 metal binding site [ion binding]; metal-binding site 469383007706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 469383007707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383007708 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 469383007709 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 469383007710 Amidohydrolase; Region: Amidohydro_2; pfam04909 469383007711 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 469383007712 iron-sulfur cluster [ion binding]; other site 469383007713 [2Fe-2S] cluster binding site [ion binding]; other site 469383007714 Putative cyclase; Region: Cyclase; pfam04199 469383007715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383007716 DNA-binding site [nucleotide binding]; DNA binding site 469383007717 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383007718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383007719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383007720 DNA binding site [nucleotide binding] 469383007721 domain linker motif; other site 469383007722 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383007723 dimerization interface [polypeptide binding]; other site 469383007724 ligand binding site [chemical binding]; other site 469383007725 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383007726 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383007727 TM-ABC transporter signature motif; other site 469383007728 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383007729 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383007730 ligand binding site [chemical binding]; other site 469383007731 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383007732 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383007733 Walker A/P-loop; other site 469383007734 ATP binding site [chemical binding]; other site 469383007735 Q-loop/lid; other site 469383007736 ABC transporter signature motif; other site 469383007737 Walker B; other site 469383007738 D-loop; other site 469383007739 H-loop/switch region; other site 469383007740 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383007741 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383007742 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383007743 TM-ABC transporter signature motif; other site 469383007744 classical (c) SDRs; Region: SDR_c; cd05233 469383007745 NAD(P) binding site [chemical binding]; other site 469383007746 active site 469383007747 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 469383007748 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383007749 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383007750 active site 469383007751 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383007752 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383007753 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383007754 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383007755 Walker A/P-loop; other site 469383007756 ATP binding site [chemical binding]; other site 469383007757 Q-loop/lid; other site 469383007758 ABC transporter signature motif; other site 469383007759 Walker B; other site 469383007760 D-loop; other site 469383007761 H-loop/switch region; other site 469383007762 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383007763 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383007764 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383007765 TM-ABC transporter signature motif; other site 469383007766 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383007767 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383007768 TM-ABC transporter signature motif; other site 469383007769 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383007770 E3 interaction surface; other site 469383007771 lipoyl attachment site [posttranslational modification]; other site 469383007772 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383007773 tetramer interface [polypeptide binding]; other site 469383007774 TPP-binding site [chemical binding]; other site 469383007775 heterodimer interface [polypeptide binding]; other site 469383007776 phosphorylation loop region [posttranslational modification] 469383007777 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383007778 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383007779 alpha subunit interface [polypeptide binding]; other site 469383007780 TPP binding site [chemical binding]; other site 469383007781 heterodimer interface [polypeptide binding]; other site 469383007782 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383007783 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383007784 classical (c) SDRs; Region: SDR_c; cd05233 469383007785 NAD(P) binding site [chemical binding]; other site 469383007786 active site 469383007787 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 469383007788 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 469383007789 ligand binding site [chemical binding]; other site 469383007790 NAD binding site [chemical binding]; other site 469383007791 catalytic site [active] 469383007792 e3 binding domain; Region: E3_binding; pfam02817 469383007793 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 469383007794 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383007795 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383007796 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383007797 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 469383007798 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383007799 active site 469383007800 ATP binding site [chemical binding]; other site 469383007801 substrate binding site [chemical binding]; other site 469383007802 enolase; Provisional; Region: eno; PRK00077 469383007803 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 469383007804 dimer interface [polypeptide binding]; other site 469383007805 metal binding site [ion binding]; metal-binding site 469383007806 substrate binding pocket [chemical binding]; other site 469383007807 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 469383007808 putative active site pocket [active] 469383007809 putative catalytic residue [active] 469383007810 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 469383007811 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 469383007812 NMT1/THI5 like; Region: NMT1; pfam09084 469383007813 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 469383007814 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 469383007815 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 469383007816 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383007817 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383007818 Walker A/P-loop; other site 469383007819 ATP binding site [chemical binding]; other site 469383007820 Q-loop/lid; other site 469383007821 ABC transporter signature motif; other site 469383007822 Walker B; other site 469383007823 D-loop; other site 469383007824 H-loop/switch region; other site 469383007825 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383007826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383007827 conserved gate region; other site 469383007828 ABC-ATPase subunit interface; other site 469383007829 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383007830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383007831 dimer interface [polypeptide binding]; other site 469383007832 conserved gate region; other site 469383007833 putative PBP binding loops; other site 469383007834 ABC-ATPase subunit interface; other site 469383007835 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383007836 active site 469383007837 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383007838 active site 469383007839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383007840 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383007841 DNA-binding site [nucleotide binding]; DNA binding site 469383007842 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383007843 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383007844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 469383007845 DNA-binding site [nucleotide binding]; DNA binding site 469383007846 FCD domain; Region: FCD; pfam07729 469383007847 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 469383007848 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 469383007849 metal binding site [ion binding]; metal-binding site 469383007850 dimer interface [polypeptide binding]; other site 469383007851 classical (c) SDRs; Region: SDR_c; cd05233 469383007852 NAD(P) binding site [chemical binding]; other site 469383007853 active site 469383007854 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383007855 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383007856 alpha subunit interface [polypeptide binding]; other site 469383007857 TPP binding site [chemical binding]; other site 469383007858 heterodimer interface [polypeptide binding]; other site 469383007859 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383007860 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 469383007861 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383007862 tetramer interface [polypeptide binding]; other site 469383007863 TPP-binding site [chemical binding]; other site 469383007864 heterodimer interface [polypeptide binding]; other site 469383007865 phosphorylation loop region [posttranslational modification] 469383007866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383007867 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383007868 active site 469383007869 metal binding site [ion binding]; metal-binding site 469383007870 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383007871 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383007872 E3 interaction surface; other site 469383007873 lipoyl attachment site [posttranslational modification]; other site 469383007874 e3 binding domain; Region: E3_binding; pfam02817 469383007875 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383007876 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 469383007877 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 469383007878 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 469383007879 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 469383007880 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 469383007881 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 469383007882 active site 469383007883 metal binding site [ion binding]; metal-binding site 469383007884 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 469383007885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383007886 DNA-binding site [nucleotide binding]; DNA binding site 469383007887 UTRA domain; Region: UTRA; pfam07702 469383007888 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383007889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383007890 Walker A/P-loop; other site 469383007891 ATP binding site [chemical binding]; other site 469383007892 Q-loop/lid; other site 469383007893 ABC transporter signature motif; other site 469383007894 Walker B; other site 469383007895 D-loop; other site 469383007896 H-loop/switch region; other site 469383007897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383007898 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 469383007899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383007900 Walker A/P-loop; other site 469383007901 ATP binding site [chemical binding]; other site 469383007902 Q-loop/lid; other site 469383007903 ABC transporter signature motif; other site 469383007904 Walker B; other site 469383007905 D-loop; other site 469383007906 H-loop/switch region; other site 469383007907 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383007908 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383007909 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383007910 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383007911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383007912 dimer interface [polypeptide binding]; other site 469383007913 conserved gate region; other site 469383007914 putative PBP binding loops; other site 469383007915 ABC-ATPase subunit interface; other site 469383007916 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 469383007917 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383007918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383007919 dimer interface [polypeptide binding]; other site 469383007920 conserved gate region; other site 469383007921 putative PBP binding loops; other site 469383007922 ABC-ATPase subunit interface; other site 469383007923 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 469383007924 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 469383007925 metal binding site [ion binding]; metal-binding site 469383007926 dimer interface [polypeptide binding]; other site 469383007927 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 469383007928 putative active site [active] 469383007929 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383007930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383007931 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383007932 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383007933 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383007934 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383007935 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383007936 TM-ABC transporter signature motif; other site 469383007937 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383007938 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383007939 TM-ABC transporter signature motif; other site 469383007940 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383007941 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383007942 Walker A/P-loop; other site 469383007943 ATP binding site [chemical binding]; other site 469383007944 Q-loop/lid; other site 469383007945 ABC transporter signature motif; other site 469383007946 Walker B; other site 469383007947 D-loop; other site 469383007948 H-loop/switch region; other site 469383007949 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383007950 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383007951 Walker A/P-loop; other site 469383007952 ATP binding site [chemical binding]; other site 469383007953 Q-loop/lid; other site 469383007954 ABC transporter signature motif; other site 469383007955 Walker B; other site 469383007956 D-loop; other site 469383007957 H-loop/switch region; other site 469383007958 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 469383007959 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 469383007960 ligand binding site [chemical binding]; other site 469383007961 Creatinine amidohydrolase; Region: Creatininase; pfam02633 469383007962 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383007963 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383007964 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383007965 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 469383007966 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 469383007967 substrate-cofactor binding pocket; other site 469383007968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383007969 catalytic residue [active] 469383007970 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 469383007971 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383007972 NAD(P) binding site [chemical binding]; other site 469383007973 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383007974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383007975 dimer interface [polypeptide binding]; other site 469383007976 conserved gate region; other site 469383007977 ABC-ATPase subunit interface; other site 469383007978 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383007979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383007980 dimer interface [polypeptide binding]; other site 469383007981 conserved gate region; other site 469383007982 putative PBP binding loops; other site 469383007983 ABC-ATPase subunit interface; other site 469383007984 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383007985 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383007986 Walker A/P-loop; other site 469383007987 ATP binding site [chemical binding]; other site 469383007988 Q-loop/lid; other site 469383007989 ABC transporter signature motif; other site 469383007990 Walker B; other site 469383007991 D-loop; other site 469383007992 H-loop/switch region; other site 469383007993 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383007994 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 469383007995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383007996 Walker A/P-loop; other site 469383007997 ATP binding site [chemical binding]; other site 469383007998 Q-loop/lid; other site 469383007999 ABC transporter signature motif; other site 469383008000 Walker B; other site 469383008001 D-loop; other site 469383008002 H-loop/switch region; other site 469383008003 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383008004 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 469383008005 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383008006 active site 469383008007 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383008008 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383008009 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 469383008010 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383008011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383008012 catalytic residue [active] 469383008013 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 469383008014 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383008015 acetylornithine deacetylase; Validated; Region: PRK06915 469383008016 metal binding site [ion binding]; metal-binding site 469383008017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 469383008018 MOSC domain; Region: MOSC; pfam03473 469383008019 3-alpha domain; Region: 3-alpha; pfam03475 469383008020 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 469383008021 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 469383008022 FAD binding pocket [chemical binding]; other site 469383008023 conserved FAD binding motif [chemical binding]; other site 469383008024 phosphate binding motif [ion binding]; other site 469383008025 beta-alpha-beta structure motif; other site 469383008026 NAD binding pocket [chemical binding]; other site 469383008027 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 469383008028 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383008029 catalytic loop [active] 469383008030 iron binding site [ion binding]; other site 469383008031 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 469383008032 substrate binding site [chemical binding]; other site 469383008033 THF binding site; other site 469383008034 zinc-binding site [ion binding]; other site 469383008035 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383008036 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383008037 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383008038 Cupin domain; Region: Cupin_2; cl17218 469383008039 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383008040 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383008041 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 469383008042 substrate binding site [chemical binding]; other site 469383008043 THF binding site; other site 469383008044 zinc-binding site [ion binding]; other site 469383008045 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 469383008046 Cupin domain; Region: Cupin_2; pfam07883 469383008047 Cupin domain; Region: Cupin_2; pfam07883 469383008048 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383008049 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383008050 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 469383008051 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 469383008052 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 469383008053 acyl-activating enzyme (AAE) consensus motif; other site 469383008054 active site 469383008055 AMP binding site [chemical binding]; other site 469383008056 substrate binding site [chemical binding]; other site 469383008057 FAD binding domain; Region: FAD_binding_3; pfam01494 469383008058 hypothetical protein; Provisional; Region: PRK07236 469383008059 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 469383008060 CoA binding domain; Region: CoA_binding_2; pfam13380 469383008061 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 469383008062 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 469383008063 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 469383008064 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 469383008065 active site 469383008066 NTP binding site [chemical binding]; other site 469383008067 metal binding triad [ion binding]; metal-binding site 469383008068 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 469383008069 sequence-specific DNA binding site [nucleotide binding]; other site 469383008070 salt bridge; other site 469383008071 Replication-relaxation; Region: Replic_Relax; pfam13814 469383008072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 469383008073 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 469383008074 catalytic residues [active] 469383008075 catalytic nucleophile [active] 469383008076 Presynaptic Site I dimer interface [polypeptide binding]; other site 469383008077 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 469383008078 Synaptic Flat tetramer interface [polypeptide binding]; other site 469383008079 Synaptic Site I dimer interface [polypeptide binding]; other site 469383008080 DNA binding site [nucleotide binding] 469383008081 Recombinase; Region: Recombinase; pfam07508 469383008082 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 469383008083 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 469383008084 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 469383008085 HIGH motif; other site 469383008086 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 469383008087 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 469383008088 active site 469383008089 KMSKS motif; other site 469383008090 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 469383008091 tRNA binding surface [nucleotide binding]; other site 469383008092 SLBB domain; Region: SLBB; pfam10531 469383008093 comEA protein; Region: comE; TIGR01259 469383008094 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 469383008095 Competence protein; Region: Competence; pfam03772 469383008096 Bacterial PH domain; Region: DUF304; pfam03703 469383008097 Uncharacterized conserved protein [Function unknown]; Region: COG3402 469383008098 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 469383008099 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 469383008100 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 469383008101 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 469383008102 GTP-binding protein LepA; Provisional; Region: PRK05433 469383008103 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 469383008104 G1 box; other site 469383008105 putative GEF interaction site [polypeptide binding]; other site 469383008106 GTP/Mg2+ binding site [chemical binding]; other site 469383008107 Switch I region; other site 469383008108 G2 box; other site 469383008109 G3 box; other site 469383008110 Switch II region; other site 469383008111 G4 box; other site 469383008112 G5 box; other site 469383008113 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 469383008114 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 469383008115 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 469383008116 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383008117 classical (c) SDRs; Region: SDR_c; cd05233 469383008118 NAD(P) binding site [chemical binding]; other site 469383008119 active site 469383008120 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 469383008121 active site 469383008122 catalytic site [active] 469383008123 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 469383008124 active site 2 [active] 469383008125 active site 1 [active] 469383008126 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 469383008127 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 469383008128 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 469383008129 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 469383008130 HSP70 interaction site [polypeptide binding]; other site 469383008131 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 469383008132 Zn binding sites [ion binding]; other site 469383008133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 469383008134 dimer interface [polypeptide binding]; other site 469383008135 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 469383008136 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 469383008137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383008138 S-adenosylmethionine binding site [chemical binding]; other site 469383008139 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 469383008140 active site 469383008141 catalytic triad [active] 469383008142 oxyanion hole [active] 469383008143 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 469383008144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383008145 Uncharacterized conserved protein [Function unknown]; Region: COG2128 469383008146 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 469383008147 Yqey-like protein; Region: YqeY; pfam09424 469383008148 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 469383008149 PhoH-like protein; Region: PhoH; pfam02562 469383008150 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 469383008151 GTPase Era; Reviewed; Region: era; PRK00089 469383008152 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 469383008153 G1 box; other site 469383008154 GTP/Mg2+ binding site [chemical binding]; other site 469383008155 Switch I region; other site 469383008156 G2 box; other site 469383008157 Switch II region; other site 469383008158 G3 box; other site 469383008159 G4 box; other site 469383008160 G5 box; other site 469383008161 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 469383008162 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 469383008163 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 469383008164 metal binding site [ion binding]; metal-binding site 469383008165 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 469383008166 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 469383008167 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 469383008168 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 469383008169 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 469383008170 glutamine binding [chemical binding]; other site 469383008171 catalytic triad [active] 469383008172 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 469383008173 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 469383008174 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 469383008175 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 469383008176 active site 469383008177 ribulose/triose binding site [chemical binding]; other site 469383008178 phosphate binding site [ion binding]; other site 469383008179 substrate (anthranilate) binding pocket [chemical binding]; other site 469383008180 product (indole) binding pocket [chemical binding]; other site 469383008181 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 469383008182 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 469383008183 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 469383008184 protein binding site [polypeptide binding]; other site 469383008185 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 469383008186 active site 469383008187 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 469383008188 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 469383008189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383008190 catalytic residue [active] 469383008191 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 469383008192 substrate binding site [chemical binding]; other site 469383008193 active site 469383008194 catalytic residues [active] 469383008195 heterodimer interface [polypeptide binding]; other site 469383008196 6-phosphofructokinase; Provisional; Region: PRK03202 469383008197 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 469383008198 active site 469383008199 ADP/pyrophosphate binding site [chemical binding]; other site 469383008200 dimerization interface [polypeptide binding]; other site 469383008201 allosteric effector site; other site 469383008202 fructose-1,6-bisphosphate binding site; other site 469383008203 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383008204 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 469383008205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383008206 TIGR01777 family protein; Region: yfcH 469383008207 NAD(P) binding site [chemical binding]; other site 469383008208 active site 469383008209 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 469383008210 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 469383008211 Malic enzyme, N-terminal domain; Region: malic; pfam00390 469383008212 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 469383008213 putative NAD(P) binding site [chemical binding]; other site 469383008214 DNA polymerase I; Provisional; Region: PRK05755 469383008215 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 469383008216 active site 469383008217 metal binding site 1 [ion binding]; metal-binding site 469383008218 putative 5' ssDNA interaction site; other site 469383008219 metal binding site 3; metal-binding site 469383008220 metal binding site 2 [ion binding]; metal-binding site 469383008221 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 469383008222 putative DNA binding site [nucleotide binding]; other site 469383008223 putative metal binding site [ion binding]; other site 469383008224 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 469383008225 active site 469383008226 substrate binding site [chemical binding]; other site 469383008227 catalytic site [active] 469383008228 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 469383008229 active site 469383008230 DNA binding site [nucleotide binding] 469383008231 catalytic site [active] 469383008232 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 469383008233 Domain of unknown function DUF20; Region: UPF0118; pfam01594 469383008234 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 469383008235 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 469383008236 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 469383008237 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 469383008238 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 469383008239 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 469383008240 RNA binding site [nucleotide binding]; other site 469383008241 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 469383008242 RNA binding site [nucleotide binding]; other site 469383008243 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 469383008244 RNA binding site [nucleotide binding]; other site 469383008245 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 469383008246 RNA binding site [nucleotide binding]; other site 469383008247 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 469383008248 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 469383008249 CoA-binding site [chemical binding]; other site 469383008250 ATP-binding [chemical binding]; other site 469383008251 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 469383008252 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 469383008253 N-acetyl-D-glucosamine binding site [chemical binding]; other site 469383008254 catalytic residue [active] 469383008255 excinuclease ABC subunit B; Provisional; Region: PRK05298 469383008256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383008257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383008258 nucleotide binding region [chemical binding]; other site 469383008259 ATP-binding site [chemical binding]; other site 469383008260 Ultra-violet resistance protein B; Region: UvrB; pfam12344 469383008261 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 469383008262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 469383008263 minor groove reading motif; other site 469383008264 helix-hairpin-helix signature motif; other site 469383008265 active site 469383008266 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 469383008267 DivIVA protein; Region: DivIVA; pfam05103 469383008268 DivIVA domain; Region: DivI1A_domain; TIGR03544 469383008269 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383008270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383008271 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383008272 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 469383008273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383008274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383008275 DNA binding residues [nucleotide binding] 469383008276 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 469383008277 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 469383008278 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 469383008279 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 469383008280 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 469383008281 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 469383008282 trimer interface [polypeptide binding]; other site 469383008283 active site 469383008284 substrate binding site [chemical binding]; other site 469383008285 CoA binding site [chemical binding]; other site 469383008286 Beta propeller domain; Region: Beta_propel; pfam09826 469383008287 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 469383008288 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 469383008289 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 469383008290 oligomerization interface [polypeptide binding]; other site 469383008291 active site 469383008292 metal binding site [ion binding]; metal-binding site 469383008293 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 469383008294 tetramerization interface [polypeptide binding]; other site 469383008295 active site 469383008296 pantoate--beta-alanine ligase; Region: panC; TIGR00018 469383008297 Pantoate-beta-alanine ligase; Region: PanC; cd00560 469383008298 active site 469383008299 ATP-binding site [chemical binding]; other site 469383008300 pantoate-binding site; other site 469383008301 HXXH motif; other site 469383008302 Uncharacterized conserved protein [Function unknown]; Region: COG5495 469383008303 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 469383008304 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 469383008305 Fe-S cluster binding site [ion binding]; other site 469383008306 active site 469383008307 AAA ATPase domain; Region: AAA_16; pfam13191 469383008308 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 469383008309 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 469383008310 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 469383008311 Glycoprotease family; Region: Peptidase_M22; pfam00814 469383008312 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 469383008313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383008314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 469383008315 Coenzyme A binding pocket [chemical binding]; other site 469383008316 UGMP family protein; Validated; Region: PRK09604 469383008317 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 469383008318 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 469383008319 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 469383008320 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 469383008321 CoA binding domain; Region: CoA_binding; cl17356 469383008322 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 469383008323 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 469383008324 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 469383008325 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 469383008326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383008327 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 469383008328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383008329 Ligand Binding Site [chemical binding]; other site 469383008330 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 469383008331 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383008332 Ligand Binding Site [chemical binding]; other site 469383008333 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 469383008334 TrkA-N domain; Region: TrkA_N; pfam02254 469383008335 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 469383008336 TrkA-N domain; Region: TrkA_N; pfam02254 469383008337 TrkA-C domain; Region: TrkA_C; pfam02080 469383008338 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 469383008339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383008340 CHASE2 domain; Region: CHASE2; pfam05226 469383008341 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 469383008342 cyclase homology domain; Region: CHD; cd07302 469383008343 nucleotidyl binding site; other site 469383008344 metal binding site [ion binding]; metal-binding site 469383008345 dimer interface [polypeptide binding]; other site 469383008346 NHL repeat; Region: NHL; pfam01436 469383008347 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 469383008348 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469383008349 ligand binding site [chemical binding]; other site 469383008350 flexible hinge region; other site 469383008351 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 469383008352 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 469383008353 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 469383008354 NAD binding site [chemical binding]; other site 469383008355 catalytic Zn binding site [ion binding]; other site 469383008356 structural Zn binding site [ion binding]; other site 469383008357 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469383008358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469383008359 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 469383008360 Walker A/P-loop; other site 469383008361 ATP binding site [chemical binding]; other site 469383008362 Q-loop/lid; other site 469383008363 ABC transporter signature motif; other site 469383008364 Walker B; other site 469383008365 D-loop; other site 469383008366 H-loop/switch region; other site 469383008367 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 469383008368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469383008369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383008370 Walker A/P-loop; other site 469383008371 ATP binding site [chemical binding]; other site 469383008372 Q-loop/lid; other site 469383008373 ABC transporter signature motif; other site 469383008374 Walker B; other site 469383008375 D-loop; other site 469383008376 H-loop/switch region; other site 469383008377 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 469383008378 cleavage site 469383008379 active site 469383008380 substrate binding sites [chemical binding]; other site 469383008381 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 469383008382 substrate binding sites [chemical binding]; other site 469383008383 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 469383008384 cleavage site 469383008385 active site 469383008386 substrate binding sites [chemical binding]; other site 469383008387 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383008388 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 469383008389 tetramerization interface [polypeptide binding]; other site 469383008390 NAD(P) binding site [chemical binding]; other site 469383008391 catalytic residues [active] 469383008392 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 469383008393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383008394 Walker A motif; other site 469383008395 ATP binding site [chemical binding]; other site 469383008396 Walker B motif; other site 469383008397 arginine finger; other site 469383008398 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 469383008399 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383008400 active site 469383008401 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 469383008402 active site 469383008403 catalytic triad [active] 469383008404 oxyanion hole [active] 469383008405 Transcriptional regulators [Transcription]; Region: MarR; COG1846 469383008406 MarR family; Region: MarR; pfam01047 469383008407 Uncharacterized conserved protein [Function unknown]; Region: COG2353 469383008408 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383008409 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383008410 metal binding site [ion binding]; metal-binding site 469383008411 active site 469383008412 I-site; other site 469383008413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383008414 Zn2+ binding site [ion binding]; other site 469383008415 Mg2+ binding site [ion binding]; other site 469383008416 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383008417 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383008418 Walker A/P-loop; other site 469383008419 ATP binding site [chemical binding]; other site 469383008420 Q-loop/lid; other site 469383008421 ABC transporter signature motif; other site 469383008422 Walker B; other site 469383008423 D-loop; other site 469383008424 H-loop/switch region; other site 469383008425 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383008426 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383008427 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 469383008428 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 469383008429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383008430 putative PBP binding loops; other site 469383008431 dimer interface [polypeptide binding]; other site 469383008432 ABC-ATPase subunit interface; other site 469383008433 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383008434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383008435 dimer interface [polypeptide binding]; other site 469383008436 conserved gate region; other site 469383008437 putative PBP binding loops; other site 469383008438 ABC-ATPase subunit interface; other site 469383008439 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383008440 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 469383008441 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383008442 Creatinine amidohydrolase; Region: Creatininase; pfam02633 469383008443 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 469383008444 active site 469383008445 intersubunit interface [polypeptide binding]; other site 469383008446 catalytic residue [active] 469383008447 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 469383008448 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 469383008449 inhibitor site; inhibition site 469383008450 active site 469383008451 dimer interface [polypeptide binding]; other site 469383008452 catalytic residue [active] 469383008453 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383008454 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383008455 metal binding site [ion binding]; metal-binding site 469383008456 substrate binding pocket [chemical binding]; other site 469383008457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383008458 active site 469383008459 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383008460 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383008461 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383008462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383008463 dimer interface [polypeptide binding]; other site 469383008464 conserved gate region; other site 469383008465 putative PBP binding loops; other site 469383008466 ABC-ATPase subunit interface; other site 469383008467 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383008468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383008469 dimer interface [polypeptide binding]; other site 469383008470 conserved gate region; other site 469383008471 putative PBP binding loops; other site 469383008472 ABC-ATPase subunit interface; other site 469383008473 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383008474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383008475 Walker A/P-loop; other site 469383008476 ATP binding site [chemical binding]; other site 469383008477 Q-loop/lid; other site 469383008478 ABC transporter signature motif; other site 469383008479 Walker B; other site 469383008480 D-loop; other site 469383008481 H-loop/switch region; other site 469383008482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 469383008483 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 469383008484 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383008485 Walker A/P-loop; other site 469383008486 ATP binding site [chemical binding]; other site 469383008487 Q-loop/lid; other site 469383008488 ABC transporter signature motif; other site 469383008489 Walker B; other site 469383008490 D-loop; other site 469383008491 H-loop/switch region; other site 469383008492 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383008493 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 469383008494 homotrimer interaction site [polypeptide binding]; other site 469383008495 putative active site [active] 469383008496 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 469383008497 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383008498 active site 469383008499 catalytic tetrad [active] 469383008500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383008501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383008502 putative substrate translocation pore; other site 469383008503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383008504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383008505 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 469383008506 Walker A/P-loop; other site 469383008507 ATP binding site [chemical binding]; other site 469383008508 Q-loop/lid; other site 469383008509 ABC transporter signature motif; other site 469383008510 Walker B; other site 469383008511 D-loop; other site 469383008512 H-loop/switch region; other site 469383008513 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 469383008514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383008515 Walker A/P-loop; other site 469383008516 ATP binding site [chemical binding]; other site 469383008517 Q-loop/lid; other site 469383008518 ABC transporter signature motif; other site 469383008519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383008520 ABC transporter signature motif; other site 469383008521 Walker B; other site 469383008522 D-loop; other site 469383008523 H-loop/switch region; other site 469383008524 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 469383008525 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469383008526 active site 469383008527 metal binding site [ion binding]; metal-binding site 469383008528 DNA binding site [nucleotide binding] 469383008529 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 469383008530 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 469383008531 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 469383008532 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383008533 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383008534 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383008535 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 469383008536 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 469383008537 putative active site [active] 469383008538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383008539 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 469383008540 RNA/DNA hybrid binding site [nucleotide binding]; other site 469383008541 active site 469383008542 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 469383008543 active site 469383008544 NTP binding site [chemical binding]; other site 469383008545 metal binding triad [ion binding]; metal-binding site 469383008546 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 469383008547 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 469383008548 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383008549 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 469383008550 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 469383008551 Creatinine amidohydrolase; Region: Creatininase; pfam02633 469383008552 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 469383008553 active site 469383008554 intersubunit interface [polypeptide binding]; other site 469383008555 catalytic residue [active] 469383008556 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383008557 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 469383008558 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 469383008559 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 469383008560 nucleotide binding site [chemical binding]; other site 469383008561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 469383008562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383008563 DNA-binding site [nucleotide binding]; DNA binding site 469383008564 UTRA domain; Region: UTRA; pfam07702 469383008565 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383008566 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383008567 TM-ABC transporter signature motif; other site 469383008568 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383008569 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383008570 TM-ABC transporter signature motif; other site 469383008571 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383008572 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383008573 Walker A/P-loop; other site 469383008574 ATP binding site [chemical binding]; other site 469383008575 Q-loop/lid; other site 469383008576 ABC transporter signature motif; other site 469383008577 Walker B; other site 469383008578 D-loop; other site 469383008579 H-loop/switch region; other site 469383008580 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383008581 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383008582 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383008583 Cupin domain; Region: Cupin_2; pfam07883 469383008584 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 469383008585 Interdomain contacts; other site 469383008586 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383008587 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383008588 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 469383008589 Htaa; Region: HtaA; pfam04213 469383008590 Htaa; Region: HtaA; pfam04213 469383008591 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383008592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383008593 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 469383008594 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 469383008595 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 469383008596 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 469383008597 TMP-binding site; other site 469383008598 ATP-binding site [chemical binding]; other site 469383008599 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 469383008600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383008601 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383008602 Amidase; Region: Amidase; cl11426 469383008603 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383008604 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 469383008605 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 469383008606 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383008607 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383008608 active site 469383008609 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 469383008610 heme-binding site [chemical binding]; other site 469383008611 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 469383008612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383008613 S-adenosylmethionine binding site [chemical binding]; other site 469383008614 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 469383008615 Uncharacterized conserved protein [Function unknown]; Region: COG3268 469383008616 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383008617 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469383008618 active site 469383008619 catalytic tetrad [active] 469383008620 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 469383008621 glutamate formiminotransferase; Region: FtcD; TIGR02024 469383008622 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 469383008623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383008624 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 469383008625 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 469383008626 dimer interface [polypeptide binding]; other site 469383008627 motif 1; other site 469383008628 active site 469383008629 motif 2; other site 469383008630 motif 3; other site 469383008631 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 469383008632 anticodon binding site; other site 469383008633 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 469383008634 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 469383008635 dimer interface [polypeptide binding]; other site 469383008636 anticodon binding site; other site 469383008637 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 469383008638 homodimer interface [polypeptide binding]; other site 469383008639 motif 1; other site 469383008640 active site 469383008641 motif 2; other site 469383008642 GAD domain; Region: GAD; pfam02938 469383008643 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 469383008644 active site 469383008645 motif 3; other site 469383008646 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 469383008647 active site 469383008648 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 469383008649 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 469383008650 Ligand Binding Site [chemical binding]; other site 469383008651 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 469383008652 putative ligand binding site [chemical binding]; other site 469383008653 putative NAD binding site [chemical binding]; other site 469383008654 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 469383008655 catalytic site [active] 469383008656 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 469383008657 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 469383008658 Sulfate transporter family; Region: Sulfate_transp; pfam00916 469383008659 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 469383008660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383008661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383008662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 469383008663 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 469383008664 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 469383008665 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 469383008666 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 469383008667 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 469383008668 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 469383008669 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 469383008670 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 469383008671 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 469383008672 XdhC Rossmann domain; Region: XdhC_C; pfam13478 469383008673 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 469383008674 metal-binding site 469383008675 MoxR-like ATPases [General function prediction only]; Region: COG0714 469383008676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 469383008677 Walker A motif; other site 469383008678 ATP binding site [chemical binding]; other site 469383008679 Walker B motif; other site 469383008680 arginine finger; other site 469383008681 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 469383008682 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 469383008683 metal ion-dependent adhesion site (MIDAS); other site 469383008684 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 469383008685 putative hydrophobic ligand binding site [chemical binding]; other site 469383008686 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 469383008687 XdhC Rossmann domain; Region: XdhC_C; pfam13478 469383008688 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 469383008689 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 469383008690 motif 1; other site 469383008691 active site 469383008692 motif 2; other site 469383008693 motif 3; other site 469383008694 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 469383008695 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 469383008696 YceG-like family; Region: YceG; pfam02618 469383008697 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 469383008698 dimerization interface [polypeptide binding]; other site 469383008699 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 469383008700 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 469383008701 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 469383008702 shikimate binding site; other site 469383008703 NAD(P) binding site [chemical binding]; other site 469383008704 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 469383008705 recombination protein F; Reviewed; Region: recF; PRK00064 469383008706 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 469383008707 RES domain; Region: RES; pfam08808 469383008708 Domain of unknown function (DUF305); Region: DUF305; pfam03713 469383008709 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 469383008710 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 469383008711 putative active site [active] 469383008712 putative metal binding residues [ion binding]; other site 469383008713 signature motif; other site 469383008714 putative triphosphate binding site [ion binding]; other site 469383008715 dimer interface [polypeptide binding]; other site 469383008716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383008717 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383008718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383008719 active site 469383008720 phosphorylation site [posttranslational modification] 469383008721 intermolecular recognition site; other site 469383008722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383008723 DNA binding residues [nucleotide binding] 469383008724 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 469383008725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383008726 S-adenosylmethionine binding site [chemical binding]; other site 469383008727 chaperone protein DnaJ; Provisional; Region: PRK14285 469383008728 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 469383008729 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 469383008730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383008731 DNA-binding site [nucleotide binding]; DNA binding site 469383008732 FCD domain; Region: FCD; pfam07729 469383008733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383008734 FAD binding domain; Region: FAD_binding_4; pfam01565 469383008735 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 469383008736 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 469383008737 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 469383008738 Tetramer interface [polypeptide binding]; other site 469383008739 active site 469383008740 FMN-binding site [chemical binding]; other site 469383008741 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 469383008742 AAA domain; Region: AAA_18; pfam13238 469383008743 ADP binding site [chemical binding]; other site 469383008744 magnesium binding site [ion binding]; other site 469383008745 putative shikimate binding site; other site 469383008746 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 469383008747 active site 469383008748 dimer interface [polypeptide binding]; other site 469383008749 metal binding site [ion binding]; metal-binding site 469383008750 Dehydroquinase class II; Region: DHquinase_II; pfam01220 469383008751 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 469383008752 trimer interface [polypeptide binding]; other site 469383008753 active site 469383008754 dimer interface [polypeptide binding]; other site 469383008755 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383008756 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383008757 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 469383008758 active site 469383008759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383008760 H+ Antiporter protein; Region: 2A0121; TIGR00900 469383008761 putative substrate translocation pore; other site 469383008762 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 469383008763 PAP2 superfamily; Region: PAP2; pfam01569 469383008764 active site 469383008765 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383008766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383008767 non-specific DNA binding site [nucleotide binding]; other site 469383008768 salt bridge; other site 469383008769 sequence-specific DNA binding site [nucleotide binding]; other site 469383008770 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383008771 Sulfatase; Region: Sulfatase; pfam00884 469383008772 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383008773 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 469383008774 Uncharacterized conserved protein [Function unknown]; Region: COG1262 469383008775 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 469383008776 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 469383008777 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 469383008778 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 469383008779 RibD C-terminal domain; Region: RibD_C; cl17279 469383008780 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 469383008781 elongation factor P; Validated; Region: PRK00529 469383008782 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 469383008783 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 469383008784 RNA binding site [nucleotide binding]; other site 469383008785 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 469383008786 RNA binding site [nucleotide binding]; other site 469383008787 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 469383008788 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 469383008789 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 469383008790 substrate binding pocket [chemical binding]; other site 469383008791 chain length determination region; other site 469383008792 substrate-Mg2+ binding site; other site 469383008793 catalytic residues [active] 469383008794 aspartate-rich region 1; other site 469383008795 active site lid residues [active] 469383008796 aspartate-rich region 2; other site 469383008797 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 469383008798 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 469383008799 TPP-binding site; other site 469383008800 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 469383008801 PYR/PP interface [polypeptide binding]; other site 469383008802 dimer interface [polypeptide binding]; other site 469383008803 TPP binding site [chemical binding]; other site 469383008804 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383008805 Calx-beta domain; Region: Calx-beta; cl02522 469383008806 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 469383008807 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 469383008808 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 469383008809 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 469383008810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383008811 S-adenosylmethionine binding site [chemical binding]; other site 469383008812 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 469383008813 ATP-NAD kinase; Region: NAD_kinase; pfam01513 469383008814 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 469383008815 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 469383008816 Walker A/P-loop; other site 469383008817 ATP binding site [chemical binding]; other site 469383008818 Q-loop/lid; other site 469383008819 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 469383008820 ABC transporter signature motif; other site 469383008821 Walker B; other site 469383008822 D-loop; other site 469383008823 H-loop/switch region; other site 469383008824 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 469383008825 Thiamine pyrophosphokinase; Region: TPK; cl08415 469383008826 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 469383008827 CTP synthetase; Validated; Region: pyrG; PRK05380 469383008828 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 469383008829 Catalytic site [active] 469383008830 active site 469383008831 UTP binding site [chemical binding]; other site 469383008832 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 469383008833 active site 469383008834 putative oxyanion hole; other site 469383008835 catalytic triad [active] 469383008836 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383008837 peptidase T-like protein; Region: PepT-like; TIGR01883 469383008838 metal binding site [ion binding]; metal-binding site 469383008839 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 469383008840 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 469383008841 dimer interface [polypeptide binding]; other site 469383008842 ADP-ribose binding site [chemical binding]; other site 469383008843 active site 469383008844 nudix motif; other site 469383008845 metal binding site [ion binding]; metal-binding site 469383008846 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 469383008847 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 469383008848 active site 469383008849 DNA binding site [nucleotide binding] 469383008850 Int/Topo IB signature motif; other site 469383008851 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 469383008852 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 469383008853 Protein of unknown function (DUF419); Region: DUF419; cl15265 469383008854 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 469383008855 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 469383008856 DNA binding site [nucleotide binding] 469383008857 catalytic residue [active] 469383008858 H2TH interface [polypeptide binding]; other site 469383008859 putative catalytic residues [active] 469383008860 turnover-facilitating residue; other site 469383008861 intercalation triad [nucleotide binding]; other site 469383008862 8OG recognition residue [nucleotide binding]; other site 469383008863 putative reading head residues; other site 469383008864 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 469383008865 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 469383008866 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 469383008867 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 469383008868 active site 469383008869 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 469383008870 DNA binding site [nucleotide binding] 469383008871 active site 469383008872 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 469383008873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469383008874 substrate binding pocket [chemical binding]; other site 469383008875 membrane-bound complex binding site; other site 469383008876 hinge residues; other site 469383008877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383008878 dimer interface [polypeptide binding]; other site 469383008879 conserved gate region; other site 469383008880 putative PBP binding loops; other site 469383008881 ABC-ATPase subunit interface; other site 469383008882 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 469383008883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383008884 Walker A/P-loop; other site 469383008885 ATP binding site [chemical binding]; other site 469383008886 Q-loop/lid; other site 469383008887 ABC transporter signature motif; other site 469383008888 Walker B; other site 469383008889 D-loop; other site 469383008890 H-loop/switch region; other site 469383008891 Domain of unknown function DUF11; Region: DUF11; cl17728 469383008892 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 469383008893 GSH binding site [chemical binding]; other site 469383008894 catalytic residues [active] 469383008895 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 469383008896 Recombination protein O N terminal; Region: RecO_N; pfam11967 469383008897 Recombination protein O C terminal; Region: RecO_C; pfam02565 469383008898 pyruvate phosphate dikinase; Provisional; Region: PRK09279 469383008899 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 469383008900 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 469383008901 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 469383008902 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 469383008903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383008904 Zn2+ binding site [ion binding]; other site 469383008905 Mg2+ binding site [ion binding]; other site 469383008906 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 469383008907 DNA primase, catalytic core; Region: dnaG; TIGR01391 469383008908 CHC2 zinc finger; Region: zf-CHC2; pfam01807 469383008909 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 469383008910 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 469383008911 active site 469383008912 metal binding site [ion binding]; metal-binding site 469383008913 interdomain interaction site; other site 469383008914 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 469383008915 Methyltransferase domain; Region: Methyltransf_11; pfam08241 469383008916 S-adenosylmethionine binding site [chemical binding]; other site 469383008917 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469383008918 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 469383008919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383008920 Walker A/P-loop; other site 469383008921 ATP binding site [chemical binding]; other site 469383008922 Q-loop/lid; other site 469383008923 ABC transporter signature motif; other site 469383008924 Walker B; other site 469383008925 D-loop; other site 469383008926 H-loop/switch region; other site 469383008927 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 469383008928 CoA binding domain; Region: CoA_binding; cl17356 469383008929 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383008930 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 469383008931 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383008932 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383008933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383008934 metal binding site [ion binding]; metal-binding site 469383008935 active site 469383008936 I-site; other site 469383008937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383008938 Zn2+ binding site [ion binding]; other site 469383008939 Mg2+ binding site [ion binding]; other site 469383008940 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383008941 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 469383008942 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383008943 classical (c) SDRs; Region: SDR_c; cd05233 469383008944 NAD(P) binding site [chemical binding]; other site 469383008945 active site 469383008946 Uncharacterized conserved protein [Function unknown]; Region: COG2128 469383008947 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 469383008948 short chain dehydrogenase; Provisional; Region: PRK06181 469383008949 classical (c) SDRs; Region: SDR_c; cd05233 469383008950 NAD(P) binding site [chemical binding]; other site 469383008951 active site 469383008952 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383008953 FAD binding domain; Region: FAD_binding_4; pfam01565 469383008954 Berberine and berberine like; Region: BBE; pfam08031 469383008955 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 469383008956 active site 469383008957 intersubunit interface [polypeptide binding]; other site 469383008958 zinc binding site [ion binding]; other site 469383008959 Na+ binding site [ion binding]; other site 469383008960 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 469383008961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383008962 motif II; other site 469383008963 DAK2 domain; Region: Dak2; cl03685 469383008964 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 469383008965 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 469383008966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383008967 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 469383008968 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383008969 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 469383008970 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383008971 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 469383008972 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383008973 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383008974 metal binding site [ion binding]; metal-binding site 469383008975 active site 469383008976 I-site; other site 469383008977 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383008978 dimer interface [polypeptide binding]; other site 469383008979 putative CheW interface [polypeptide binding]; other site 469383008980 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 469383008981 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 469383008982 putative binding surface; other site 469383008983 active site 469383008984 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 469383008985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383008986 ATP binding site [chemical binding]; other site 469383008987 Mg2+ binding site [ion binding]; other site 469383008988 G-X-G motif; other site 469383008989 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 469383008990 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 469383008991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383008992 active site 469383008993 phosphorylation site [posttranslational modification] 469383008994 intermolecular recognition site; other site 469383008995 dimerization interface [polypeptide binding]; other site 469383008996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383008997 active site 469383008998 phosphorylation site [posttranslational modification] 469383008999 intermolecular recognition site; other site 469383009000 CheB methylesterase; Region: CheB_methylest; pfam01339 469383009001 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 469383009002 Response regulator receiver domain; Region: Response_reg; pfam00072 469383009003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383009004 active site 469383009005 phosphorylation site [posttranslational modification] 469383009006 intermolecular recognition site; other site 469383009007 dimerization interface [polypeptide binding]; other site 469383009008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383009009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383009010 metal binding site [ion binding]; metal-binding site 469383009011 active site 469383009012 I-site; other site 469383009013 Response regulator receiver domain; Region: Response_reg; pfam00072 469383009014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383009015 active site 469383009016 phosphorylation site [posttranslational modification] 469383009017 intermolecular recognition site; other site 469383009018 dimerization interface [polypeptide binding]; other site 469383009019 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383009020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 469383009021 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 469383009022 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383009023 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 469383009024 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 469383009025 anti sigma factor interaction site; other site 469383009026 regulatory phosphorylation site [posttranslational modification]; other site 469383009027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 469383009028 GAF domain; Region: GAF; pfam01590 469383009029 GAF domain; Region: GAF_2; pfam13185 469383009030 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 469383009031 Male sterility protein; Region: NAD_binding_4; pfam07993 469383009032 NAD(P) binding site [chemical binding]; other site 469383009033 active site 469383009034 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383009035 FAD binding domain; Region: FAD_binding_4; pfam01565 469383009036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 469383009037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 469383009038 putative acyl-acceptor binding pocket; other site 469383009039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383009040 NAD(P) binding site [chemical binding]; other site 469383009041 active site 469383009042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383009043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383009045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009046 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 469383009047 FOG: CBS domain [General function prediction only]; Region: COG0517 469383009048 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 469383009049 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 469383009050 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 469383009051 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 469383009052 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 469383009053 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 469383009054 putative active site [active] 469383009055 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 469383009056 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 469383009057 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 469383009058 active site 469383009059 multimer interface [polypeptide binding]; other site 469383009060 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 469383009061 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 469383009062 predicted active site [active] 469383009063 catalytic triad [active] 469383009064 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383009065 NAD(P) binding site [chemical binding]; other site 469383009066 catalytic residues [active] 469383009067 Proline dehydrogenase; Region: Pro_dh; cl03282 469383009068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383009069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383009071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009072 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383009073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383009074 putative DNA binding site [nucleotide binding]; other site 469383009075 dimerization interface [polypeptide binding]; other site 469383009076 putative Zn2+ binding site [ion binding]; other site 469383009077 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 469383009078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383009079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 469383009080 Walker A motif; other site 469383009081 ATP binding site [chemical binding]; other site 469383009082 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 469383009083 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383009084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383009085 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 469383009086 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 469383009087 active site 469383009088 substrate binding site [chemical binding]; other site 469383009089 metal binding site [ion binding]; metal-binding site 469383009090 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 469383009091 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469383009092 active site 469383009093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383009094 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383009095 NAD(P) binding site [chemical binding]; other site 469383009096 active site 469383009097 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 469383009098 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 469383009099 hypothetical protein; Validated; Region: PRK00110 469383009100 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 469383009101 active site 469383009102 putative DNA-binding cleft [nucleotide binding]; other site 469383009103 dimer interface [polypeptide binding]; other site 469383009104 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 469383009105 RuvA N terminal domain; Region: RuvA_N; pfam01330 469383009106 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 469383009107 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 469383009108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383009109 Walker A motif; other site 469383009110 ATP binding site [chemical binding]; other site 469383009111 Walker B motif; other site 469383009112 arginine finger; other site 469383009113 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 469383009114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383009115 PAS domain; Region: PAS_9; pfam13426 469383009116 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 469383009117 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 469383009118 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 469383009119 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 469383009120 Protein export membrane protein; Region: SecD_SecF; pfam02355 469383009121 hypothetical protein; Provisional; Region: PRK01346 469383009122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383009123 Coenzyme A binding pocket [chemical binding]; other site 469383009124 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 469383009125 DHH family; Region: DHH; pfam01368 469383009126 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 469383009127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383009128 Zn2+ binding site [ion binding]; other site 469383009129 Mg2+ binding site [ion binding]; other site 469383009130 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 469383009131 synthetase active site [active] 469383009132 NTP binding site [chemical binding]; other site 469383009133 metal binding site [ion binding]; metal-binding site 469383009134 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 469383009135 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 469383009136 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 469383009137 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 469383009138 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 469383009139 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 469383009140 oligomer interface [polypeptide binding]; other site 469383009141 metal binding site [ion binding]; metal-binding site 469383009142 metal binding site [ion binding]; metal-binding site 469383009143 putative Cl binding site [ion binding]; other site 469383009144 aspartate ring; other site 469383009145 basic sphincter; other site 469383009146 hydrophobic gate; other site 469383009147 periplasmic entrance; other site 469383009148 threonine synthase; Validated; Region: PRK07591 469383009149 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 469383009150 homodimer interface [polypeptide binding]; other site 469383009151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383009152 catalytic residue [active] 469383009153 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 469383009154 MoaE interaction surface [polypeptide binding]; other site 469383009155 MoeB interaction surface [polypeptide binding]; other site 469383009156 thiocarboxylated glycine; other site 469383009157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383009158 non-specific DNA binding site [nucleotide binding]; other site 469383009159 salt bridge; other site 469383009160 sequence-specific DNA binding site [nucleotide binding]; other site 469383009161 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 469383009162 active site 469383009163 metal binding site [ion binding]; metal-binding site 469383009164 homotetramer interface [polypeptide binding]; other site 469383009165 ribonuclease Z; Region: RNase_Z; TIGR02651 469383009166 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 469383009167 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 469383009168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469383009169 active site 469383009170 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 469383009171 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 469383009172 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 469383009173 dihydroorotase; Validated; Region: pyrC; PRK09357 469383009174 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383009175 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 469383009176 active site 469383009177 Isochorismatase family; Region: Isochorismatase; pfam00857 469383009178 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 469383009179 catalytic triad [active] 469383009180 dimer interface [polypeptide binding]; other site 469383009181 conserved cis-peptide bond; other site 469383009182 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 469383009183 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 469383009184 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 469383009185 catalytic site [active] 469383009186 subunit interface [polypeptide binding]; other site 469383009187 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 469383009188 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 469383009189 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383009190 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 469383009191 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 469383009192 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383009193 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 469383009194 IMP binding site; other site 469383009195 dimer interface [polypeptide binding]; other site 469383009196 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 469383009197 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 469383009198 FAD binding pocket [chemical binding]; other site 469383009199 FAD binding motif [chemical binding]; other site 469383009200 phosphate binding motif [ion binding]; other site 469383009201 beta-alpha-beta structure motif; other site 469383009202 NAD binding pocket [chemical binding]; other site 469383009203 Iron coordination center [ion binding]; other site 469383009204 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 469383009205 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 469383009206 phosphate binding site [ion binding]; other site 469383009207 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 469383009208 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 469383009209 catalytic site [active] 469383009210 G-X2-G-X-G-K; other site 469383009211 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 469383009212 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 469383009213 Flavoprotein; Region: Flavoprotein; pfam02441 469383009214 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 469383009215 MoxR-like ATPases [General function prediction only]; Region: COG0714 469383009216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383009217 Walker A motif; other site 469383009218 ATP binding site [chemical binding]; other site 469383009219 Walker B motif; other site 469383009220 arginine finger; other site 469383009221 Protein of unknown function DUF58; Region: DUF58; pfam01882 469383009222 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 469383009223 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 469383009224 Vi polysaccharide export protein VexE; Provisional; Region: PRK15174 469383009225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383009226 Walker A/P-loop; other site 469383009227 ATP binding site [chemical binding]; other site 469383009228 Q-loop/lid; other site 469383009229 ABC transporter signature motif; other site 469383009230 Walker B; other site 469383009231 D-loop; other site 469383009232 H-loop/switch region; other site 469383009233 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 469383009234 ribosome maturation protein RimP; Reviewed; Region: PRK00092 469383009235 Sm and related proteins; Region: Sm_like; cl00259 469383009236 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 469383009237 putative oligomer interface [polypeptide binding]; other site 469383009238 putative RNA binding site [nucleotide binding]; other site 469383009239 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 469383009240 NusA N-terminal domain; Region: NusA_N; pfam08529 469383009241 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 469383009242 RNA binding site [nucleotide binding]; other site 469383009243 homodimer interface [polypeptide binding]; other site 469383009244 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 469383009245 G-X-X-G motif; other site 469383009246 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 469383009247 G-X-X-G motif; other site 469383009248 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 469383009249 translation initiation factor IF-2; Region: IF-2; TIGR00487 469383009250 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 469383009251 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 469383009252 G1 box; other site 469383009253 putative GEF interaction site [polypeptide binding]; other site 469383009254 GTP/Mg2+ binding site [chemical binding]; other site 469383009255 Switch I region; other site 469383009256 G2 box; other site 469383009257 G3 box; other site 469383009258 Switch II region; other site 469383009259 G4 box; other site 469383009260 G5 box; other site 469383009261 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 469383009262 Translation-initiation factor 2; Region: IF-2; pfam11987 469383009263 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 469383009264 Protein of unknown function (DUF503); Region: DUF503; pfam04456 469383009265 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 469383009266 DHH family; Region: DHH; pfam01368 469383009267 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 469383009268 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 469383009269 active site 469383009270 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 469383009271 putative active site [active] 469383009272 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 469383009273 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 469383009274 active site 469383009275 Riboflavin kinase; Region: Flavokinase; smart00904 469383009276 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 469383009277 16S/18S rRNA binding site [nucleotide binding]; other site 469383009278 S13e-L30e interaction site [polypeptide binding]; other site 469383009279 25S rRNA binding site [nucleotide binding]; other site 469383009280 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383009281 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469383009282 Thioredoxin; Region: Thioredoxin_4; cl17273 469383009283 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 469383009284 putative hydrophobic ligand binding site [chemical binding]; other site 469383009285 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 469383009286 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 469383009287 RNase E interface [polypeptide binding]; other site 469383009288 trimer interface [polypeptide binding]; other site 469383009289 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 469383009290 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 469383009291 RNase E interface [polypeptide binding]; other site 469383009292 trimer interface [polypeptide binding]; other site 469383009293 active site 469383009294 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 469383009295 putative nucleic acid binding region [nucleotide binding]; other site 469383009296 G-X-X-G motif; other site 469383009297 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 469383009298 RNA binding site [nucleotide binding]; other site 469383009299 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 469383009300 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 469383009301 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 469383009302 dihydrodipicolinate reductase; Provisional; Region: PRK00048 469383009303 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 469383009304 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 469383009305 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 469383009306 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 469383009307 dimer interface [polypeptide binding]; other site 469383009308 active site 469383009309 catalytic residue [active] 469383009310 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 469383009311 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383009312 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 469383009313 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 469383009314 dimerization interface [polypeptide binding]; other site 469383009315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383009316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383009317 dimer interface [polypeptide binding]; other site 469383009318 phosphorylation site [posttranslational modification] 469383009319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383009320 ATP binding site [chemical binding]; other site 469383009321 Mg2+ binding site [ion binding]; other site 469383009322 G-X-G motif; other site 469383009323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383009324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383009325 active site 469383009326 phosphorylation site [posttranslational modification] 469383009327 intermolecular recognition site; other site 469383009328 dimerization interface [polypeptide binding]; other site 469383009329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383009330 DNA binding site [nucleotide binding] 469383009331 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 469383009332 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 469383009333 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 469383009334 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 469383009335 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383009336 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383009337 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 469383009338 Helix-turn-helix domain; Region: HTH_25; pfam13413 469383009339 competence damage-inducible protein A; Provisional; Region: PRK00549 469383009340 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 469383009341 putative MPT binding site; other site 469383009342 Competence-damaged protein; Region: CinA; pfam02464 469383009343 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 469383009344 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 469383009345 recombinase A; Provisional; Region: recA; PRK09354 469383009346 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 469383009347 hexamer interface [polypeptide binding]; other site 469383009348 Walker A motif; other site 469383009349 ATP binding site [chemical binding]; other site 469383009350 Walker B motif; other site 469383009351 recombination regulator RecX; Provisional; Region: recX; PRK14137 469383009352 recombination regulator RecX; Reviewed; Region: recX; PRK00117 469383009353 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 469383009354 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 469383009355 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383009356 Zn2+ binding site [ion binding]; other site 469383009357 Mg2+ binding site [ion binding]; other site 469383009358 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 469383009359 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 469383009360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383009361 FeS/SAM binding site; other site 469383009362 TRAM domain; Region: TRAM; pfam01938 469383009363 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 469383009364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383009365 motif II; other site 469383009366 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 469383009367 protein-splicing catalytic site; other site 469383009368 thioester formation/cholesterol transfer; other site 469383009369 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 469383009370 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 469383009371 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 469383009372 Mechanosensitive ion channel; Region: MS_channel; pfam00924 469383009373 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 469383009374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383009375 NAD(P) binding site [chemical binding]; other site 469383009376 active site 469383009377 FIST N domain; Region: FIST; pfam08495 469383009378 FIST C domain; Region: FIST_C; pfam10442 469383009379 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 469383009380 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 469383009381 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 469383009382 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 469383009383 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 469383009384 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 469383009385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383009386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383009387 homodimer interface [polypeptide binding]; other site 469383009388 catalytic residue [active] 469383009389 Protein of unknown function DUF262; Region: DUF262; pfam03235 469383009390 Uncharacterized conserved protein [Function unknown]; Region: COG1479 469383009391 Uncharacterized conserved protein [Function unknown]; Region: COG3472 469383009392 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 469383009393 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 469383009394 HflX GTPase family; Region: HflX; cd01878 469383009395 G1 box; other site 469383009396 GTP/Mg2+ binding site [chemical binding]; other site 469383009397 Switch I region; other site 469383009398 G2 box; other site 469383009399 G3 box; other site 469383009400 Switch II region; other site 469383009401 G4 box; other site 469383009402 G5 box; other site 469383009403 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 469383009404 trimer interface [polypeptide binding]; other site 469383009405 active site 469383009406 RNA polymerase factor sigma-70; Validated; Region: PRK08241 469383009407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383009408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383009409 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383009410 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 469383009411 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 469383009412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009413 dimer interface [polypeptide binding]; other site 469383009414 conserved gate region; other site 469383009415 putative PBP binding loops; other site 469383009416 ABC-ATPase subunit interface; other site 469383009417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009418 dimer interface [polypeptide binding]; other site 469383009419 conserved gate region; other site 469383009420 putative PBP binding loops; other site 469383009421 ABC-ATPase subunit interface; other site 469383009422 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 469383009423 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 469383009424 Walker A/P-loop; other site 469383009425 ATP binding site [chemical binding]; other site 469383009426 Q-loop/lid; other site 469383009427 ABC transporter signature motif; other site 469383009428 Walker B; other site 469383009429 D-loop; other site 469383009430 H-loop/switch region; other site 469383009431 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 469383009432 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 469383009433 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 469383009434 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 469383009435 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 469383009436 Zn binding site [ion binding]; other site 469383009437 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 469383009438 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 469383009439 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 469383009440 active site 469383009441 phosphoglycolate/pyridoxal phosphate phosphatase family; Region: PGP_euk; TIGR01452 469383009442 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 469383009443 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 469383009444 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 469383009445 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 469383009446 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 469383009447 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469383009448 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 469383009449 Methyltransferase domain; Region: Methyltransf_25; pfam13649 469383009450 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 469383009451 catalytic triad [active] 469383009452 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 469383009453 3D domain; Region: 3D; cl01439 469383009454 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 469383009455 metal binding site 2 [ion binding]; metal-binding site 469383009456 putative DNA binding helix; other site 469383009457 structural Zn2+ binding site [ion binding]; other site 469383009458 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 469383009459 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 469383009460 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383009461 NAD(P) binding site [chemical binding]; other site 469383009462 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 469383009463 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 469383009464 MoaE interaction surface [polypeptide binding]; other site 469383009465 MoeB interaction surface [polypeptide binding]; other site 469383009466 thiocarboxylated glycine; other site 469383009467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383009468 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469383009469 active site 469383009470 catalytic tetrad [active] 469383009471 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383009472 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 469383009473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383009474 putative substrate translocation pore; other site 469383009475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383009476 Domain of unknown function (DUF427); Region: DUF427; cl00998 469383009477 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 469383009478 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 469383009479 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 469383009480 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 469383009481 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 469383009482 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 469383009483 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383009484 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383009485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383009486 putative Zn2+ binding site [ion binding]; other site 469383009487 putative DNA binding site [nucleotide binding]; other site 469383009488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383009489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383009490 putative substrate translocation pore; other site 469383009491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383009492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383009493 putative substrate translocation pore; other site 469383009494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383009495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383009497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383009498 putative substrate translocation pore; other site 469383009499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383009500 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 469383009501 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 469383009502 active site 469383009503 catalytic site [active] 469383009504 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 469383009505 active site 469383009506 catalytic triad [active] 469383009507 oxyanion hole [active] 469383009508 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383009509 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 469383009510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383009511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009512 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383009513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383009514 NAD(P) binding site [chemical binding]; other site 469383009515 active site 469383009516 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 469383009517 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 469383009518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 469383009519 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383009520 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 469383009521 FAD binding domain; Region: FAD_binding_4; pfam01565 469383009522 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 469383009523 Prostaglandin dehydrogenases; Region: PGDH; cd05288 469383009524 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 469383009525 NAD(P) binding site [chemical binding]; other site 469383009526 substrate binding site [chemical binding]; other site 469383009527 dimer interface [polypeptide binding]; other site 469383009528 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 469383009529 active site 469383009530 catalytic triad [active] 469383009531 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 469383009532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383009533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 469383009534 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 469383009535 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 469383009536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 469383009537 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 469383009538 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383009539 DNA binding residues [nucleotide binding] 469383009540 Stage II sporulation protein; Region: SpoIID; pfam08486 469383009541 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 469383009542 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 469383009543 Family description; Region: VCBS; pfam13517 469383009544 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 469383009545 Putative Ig domain; Region: He_PIG; pfam05345 469383009546 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 469383009547 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 469383009548 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383009549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383009550 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 469383009551 Walker A/P-loop; other site 469383009552 ATP binding site [chemical binding]; other site 469383009553 Q-loop/lid; other site 469383009554 ABC transporter signature motif; other site 469383009555 Walker B; other site 469383009556 D-loop; other site 469383009557 H-loop/switch region; other site 469383009558 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383009559 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 469383009560 putative NAD(P) binding site [chemical binding]; other site 469383009561 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 469383009562 ATP binding site [chemical binding]; other site 469383009563 G-X-G motif; other site 469383009564 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383009565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383009566 DNA binding residues [nucleotide binding] 469383009567 dimerization interface [polypeptide binding]; other site 469383009568 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 469383009569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009570 MMPL family; Region: MMPL; pfam03176 469383009571 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383009572 Immunoglobulin domain; Region: Ig; cl11960 469383009573 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 469383009574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383009575 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383009576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383009577 DNA-binding site [nucleotide binding]; DNA binding site 469383009578 FCD domain; Region: FCD; pfam07729 469383009579 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 469383009580 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383009581 hydroxyglutarate oxidase; Provisional; Region: PRK11728 469383009582 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383009583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383009584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009585 dimer interface [polypeptide binding]; other site 469383009586 conserved gate region; other site 469383009587 ABC-ATPase subunit interface; other site 469383009588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383009589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009590 dimer interface [polypeptide binding]; other site 469383009591 conserved gate region; other site 469383009592 putative PBP binding loops; other site 469383009593 ABC-ATPase subunit interface; other site 469383009594 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383009595 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383009596 Walker A/P-loop; other site 469383009597 ATP binding site [chemical binding]; other site 469383009598 Q-loop/lid; other site 469383009599 ABC transporter signature motif; other site 469383009600 Walker B; other site 469383009601 D-loop; other site 469383009602 H-loop/switch region; other site 469383009603 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383009604 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383009605 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383009606 Walker A/P-loop; other site 469383009607 ATP binding site [chemical binding]; other site 469383009608 Q-loop/lid; other site 469383009609 ABC transporter signature motif; other site 469383009610 Walker B; other site 469383009611 D-loop; other site 469383009612 H-loop/switch region; other site 469383009613 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383009614 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383009615 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383009616 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 469383009617 active site 469383009618 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 469383009619 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383009620 active site pocket [active] 469383009621 Predicted acyl esterases [General function prediction only]; Region: COG2936 469383009622 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 469383009623 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 469383009624 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383009625 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383009626 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383009627 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 469383009628 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 469383009629 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383009630 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 469383009631 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 469383009632 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383009633 PYR/PP interface [polypeptide binding]; other site 469383009634 dimer interface [polypeptide binding]; other site 469383009635 TPP binding site [chemical binding]; other site 469383009636 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383009637 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 469383009638 TPP-binding site [chemical binding]; other site 469383009639 dimer interface [polypeptide binding]; other site 469383009640 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383009641 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383009642 active site 469383009643 metal binding site [ion binding]; metal-binding site 469383009644 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383009645 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 469383009646 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 469383009647 catalytic triad [active] 469383009648 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 469383009649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383009650 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 469383009651 Ubiquitin; Region: Ubiquitin; cd01803 469383009652 Ubiquitin family; Region: ubiquitin; pfam00240 469383009653 Ubq - E2 interaction site; other site 469383009654 Ubq - UCH interaction site; other site 469383009655 Ubq - CUE interaction site; other site 469383009656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383009657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383009658 active site 469383009659 phosphorylation site [posttranslational modification] 469383009660 intermolecular recognition site; other site 469383009661 dimerization interface [polypeptide binding]; other site 469383009662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 469383009663 DNA binding site [nucleotide binding] 469383009664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383009665 dimerization interface [polypeptide binding]; other site 469383009666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383009667 dimer interface [polypeptide binding]; other site 469383009668 phosphorylation site [posttranslational modification] 469383009669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383009670 ATP binding site [chemical binding]; other site 469383009671 G-X-G motif; other site 469383009672 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383009673 active site 469383009674 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 469383009675 putative active site [active] 469383009676 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 469383009677 Galactose oxidase, central domain; Region: Kelch_3; cl02701 469383009678 Galactose oxidase, central domain; Region: Kelch_3; cl02701 469383009679 Galactose oxidase, central domain; Region: Kelch_3; cl02701 469383009680 Kelch motif; Region: Kelch_1; pfam01344 469383009681 Kelch motif; Region: Kelch_1; pfam01344 469383009682 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 469383009683 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 469383009684 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 469383009685 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 469383009686 Family description; Region: UvrD_C_2; pfam13538 469383009687 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 469383009688 AAA domain; Region: AAA_30; pfam13604 469383009689 Family description; Region: UvrD_C_2; pfam13538 469383009690 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 469383009691 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 469383009692 active site 469383009693 substrate binding site [chemical binding]; other site 469383009694 trimer interface [polypeptide binding]; other site 469383009695 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 469383009696 CoA binding site [chemical binding]; other site 469383009697 Clp amino terminal domain; Region: Clp_N; pfam02861 469383009698 Homeodomain-like domain; Region: HTH_23; pfam13384 469383009699 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383009700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383009701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383009702 dimerization interface [polypeptide binding]; other site 469383009703 putative DNA binding site [nucleotide binding]; other site 469383009704 putative Zn2+ binding site [ion binding]; other site 469383009705 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 469383009706 hydrophobic ligand binding site; other site 469383009707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383009708 dimer interface [polypeptide binding]; other site 469383009709 putative CheW interface [polypeptide binding]; other site 469383009710 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383009711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383009712 sequence-specific DNA binding site [nucleotide binding]; other site 469383009713 salt bridge; other site 469383009714 MMPL family; Region: MMPL; pfam03176 469383009715 MMPL family; Region: MMPL; pfam03176 469383009716 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 469383009717 anti sigma factor interaction site; other site 469383009718 regulatory phosphorylation site [posttranslational modification]; other site 469383009719 DEAD-like helicases superfamily; Region: DEXDc; smart00487 469383009720 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 469383009721 ATP binding site [chemical binding]; other site 469383009722 Mg++ binding site [ion binding]; other site 469383009723 motif III; other site 469383009724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383009725 nucleotide binding region [chemical binding]; other site 469383009726 ATP-binding site [chemical binding]; other site 469383009727 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 469383009728 RNA binding site [nucleotide binding]; other site 469383009729 Uncharacterized conserved protein [Function unknown]; Region: COG5361 469383009730 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 469383009731 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 469383009732 Transglycosylase; Region: Transgly; pfam00912 469383009733 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 469383009734 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 469383009735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383009736 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 469383009737 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 469383009738 active site 469383009739 dimer interface [polypeptide binding]; other site 469383009740 non-prolyl cis peptide bond; other site 469383009741 insertion regions; other site 469383009742 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 469383009743 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469383009744 substrate binding pocket [chemical binding]; other site 469383009745 membrane-bound complex binding site; other site 469383009746 hinge residues; other site 469383009747 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383009748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383009749 Walker A/P-loop; other site 469383009750 ATP binding site [chemical binding]; other site 469383009751 Q-loop/lid; other site 469383009752 ABC transporter signature motif; other site 469383009753 Walker B; other site 469383009754 D-loop; other site 469383009755 H-loop/switch region; other site 469383009756 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383009757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009758 dimer interface [polypeptide binding]; other site 469383009759 conserved gate region; other site 469383009760 putative PBP binding loops; other site 469383009761 ABC-ATPase subunit interface; other site 469383009762 peptidase T; Region: peptidase-T; TIGR01882 469383009763 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 469383009764 metal binding site [ion binding]; metal-binding site 469383009765 dimer interface [polypeptide binding]; other site 469383009766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383009767 dimerization interface [polypeptide binding]; other site 469383009768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383009769 dimer interface [polypeptide binding]; other site 469383009770 putative CheW interface [polypeptide binding]; other site 469383009771 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 469383009772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383009773 dimerization interface [polypeptide binding]; other site 469383009774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383009775 dimer interface [polypeptide binding]; other site 469383009776 putative CheW interface [polypeptide binding]; other site 469383009777 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 469383009778 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 469383009779 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 469383009780 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383009781 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469383009782 active site 469383009783 catalytic tetrad [active] 469383009784 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 469383009785 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383009786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383009787 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 469383009788 Predicted transcriptional regulator [Transcription]; Region: COG2378 469383009789 HTH domain; Region: HTH_11; pfam08279 469383009790 WYL domain; Region: WYL; pfam13280 469383009791 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383009792 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383009793 DNA binding residues [nucleotide binding] 469383009794 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383009795 dimer interface [polypeptide binding]; other site 469383009796 putative CheW interface [polypeptide binding]; other site 469383009797 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 469383009798 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 469383009799 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 469383009800 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 469383009801 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 469383009802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383009803 Walker A/P-loop; other site 469383009804 ATP binding site [chemical binding]; other site 469383009805 Q-loop/lid; other site 469383009806 ABC transporter signature motif; other site 469383009807 Walker B; other site 469383009808 D-loop; other site 469383009809 H-loop/switch region; other site 469383009810 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383009811 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383009812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383009813 Walker A/P-loop; other site 469383009814 ATP binding site [chemical binding]; other site 469383009815 Q-loop/lid; other site 469383009816 ABC transporter signature motif; other site 469383009817 Walker B; other site 469383009818 D-loop; other site 469383009819 H-loop/switch region; other site 469383009820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383009821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383009822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009823 dimer interface [polypeptide binding]; other site 469383009824 conserved gate region; other site 469383009825 ABC-ATPase subunit interface; other site 469383009826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383009827 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 469383009828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009829 dimer interface [polypeptide binding]; other site 469383009830 conserved gate region; other site 469383009831 putative PBP binding loops; other site 469383009832 ABC-ATPase subunit interface; other site 469383009833 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383009834 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383009835 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 469383009836 putative efflux protein, MATE family; Region: matE; TIGR00797 469383009837 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383009838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383009839 NAD(P) binding site [chemical binding]; other site 469383009840 active site 469383009841 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 469383009842 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 469383009843 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 469383009844 active site 469383009845 DNA binding site [nucleotide binding] 469383009846 Int/Topo IB signature motif; other site 469383009847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383009848 S-adenosylmethionine binding site [chemical binding]; other site 469383009849 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 469383009850 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 469383009851 anti sigma factor interaction site; other site 469383009852 regulatory phosphorylation site [posttranslational modification]; other site 469383009853 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 469383009854 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383009855 ATP binding site [chemical binding]; other site 469383009856 Mg2+ binding site [ion binding]; other site 469383009857 G-X-G motif; other site 469383009858 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 469383009859 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 469383009860 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 469383009861 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 469383009862 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 469383009863 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 469383009864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 469383009865 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 469383009866 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 469383009867 catalytic residues [active] 469383009868 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 469383009869 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 469383009870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383009871 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469383009872 peptide chain release factor 1; Provisional; Region: PRK04011 469383009873 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 469383009874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383009875 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 469383009876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383009877 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 469383009878 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 469383009879 anti sigma factor interaction site; other site 469383009880 regulatory phosphorylation site [posttranslational modification]; other site 469383009881 Family description; Region: VCBS; pfam13517 469383009882 Family description; Region: VCBS; pfam13517 469383009883 Family description; Region: VCBS; pfam13517 469383009884 Htaa; Region: HtaA; pfam04213 469383009885 Htaa; Region: HtaA; pfam04213 469383009886 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 469383009887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383009888 Walker A/P-loop; other site 469383009889 ATP binding site [chemical binding]; other site 469383009890 Q-loop/lid; other site 469383009891 ABC transporter signature motif; other site 469383009892 Walker B; other site 469383009893 D-loop; other site 469383009894 H-loop/switch region; other site 469383009895 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 469383009896 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 469383009897 dimer interface [polypeptide binding]; other site 469383009898 putative PBP binding regions; other site 469383009899 ABC-ATPase subunit interface; other site 469383009900 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383009901 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 469383009902 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 469383009903 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 469383009904 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 469383009905 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 469383009906 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 469383009907 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 469383009908 dinuclear metal binding motif [ion binding]; other site 469383009909 Helix-turn-helix domain; Region: HTH_17; cl17695 469383009910 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383009911 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 469383009912 Walker A/P-loop; other site 469383009913 ATP binding site [chemical binding]; other site 469383009914 Q-loop/lid; other site 469383009915 ABC transporter signature motif; other site 469383009916 Walker B; other site 469383009917 D-loop; other site 469383009918 H-loop/switch region; other site 469383009919 TOBE domain; Region: TOBE; cl01440 469383009920 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 469383009921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383009922 putative PBP binding loops; other site 469383009923 ABC-ATPase subunit interface; other site 469383009924 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 469383009925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383009926 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 469383009927 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383009928 DNA binding residues [nucleotide binding] 469383009929 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 469383009930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383009931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383009932 catalytic residue [active] 469383009933 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 469383009934 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 469383009935 catalytic triad [active] 469383009936 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383009937 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383009938 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 469383009939 catalytic residues [active] 469383009940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 469383009941 TPR motif; other site 469383009942 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 469383009943 TrkA-N domain; Region: TrkA_N; pfam02254 469383009944 TrkA-C domain; Region: TrkA_C; pfam02080 469383009945 TrkA-N domain; Region: TrkA_N; pfam02254 469383009946 TrkA-C domain; Region: TrkA_C; pfam02080 469383009947 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 469383009948 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 469383009949 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 469383009950 active site 469383009951 DNA polymerase IV; Validated; Region: PRK02406 469383009952 DNA binding site [nucleotide binding] 469383009953 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 469383009954 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 469383009955 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 469383009956 NAD synthetase; Provisional; Region: PRK13981 469383009957 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 469383009958 multimer interface [polypeptide binding]; other site 469383009959 active site 469383009960 catalytic triad [active] 469383009961 protein interface 1 [polypeptide binding]; other site 469383009962 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 469383009963 homodimer interface [polypeptide binding]; other site 469383009964 NAD binding pocket [chemical binding]; other site 469383009965 ATP binding pocket [chemical binding]; other site 469383009966 Mg binding site [ion binding]; other site 469383009967 active-site loop [active] 469383009968 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 469383009969 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 469383009970 hexamer interface [polypeptide binding]; other site 469383009971 ligand binding site [chemical binding]; other site 469383009972 putative active site [active] 469383009973 NAD(P) binding site [chemical binding]; other site 469383009974 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383009975 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383009976 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 469383009977 CoenzymeA binding site [chemical binding]; other site 469383009978 subunit interaction site [polypeptide binding]; other site 469383009979 PHB binding site; other site 469383009980 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383009981 DNA binding residues [nucleotide binding] 469383009982 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 469383009983 hydrophobic ligand binding site; other site 469383009984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469383009985 active site 469383009986 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 469383009987 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383009988 DNA binding residues [nucleotide binding] 469383009989 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 469383009990 Double zinc ribbon; Region: DZR; pfam12773 469383009991 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 469383009992 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 469383009993 phosphopeptide binding site; other site 469383009994 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 469383009995 prolyl-tRNA synthetase; Provisional; Region: PRK09194 469383009996 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 469383009997 motif 1; other site 469383009998 dimer interface [polypeptide binding]; other site 469383009999 active site 469383010000 motif 2; other site 469383010001 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 469383010002 putative deacylase active site [active] 469383010003 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 469383010004 active site 469383010005 motif 3; other site 469383010006 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 469383010007 anticodon binding site; other site 469383010008 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383010009 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383010010 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 469383010011 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 469383010012 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 469383010013 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 469383010014 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 469383010015 putative ligand binding site [chemical binding]; other site 469383010016 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383010017 TM-ABC transporter signature motif; other site 469383010018 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383010019 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383010020 TM-ABC transporter signature motif; other site 469383010021 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 469383010022 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383010023 Walker A/P-loop; other site 469383010024 ATP binding site [chemical binding]; other site 469383010025 Q-loop/lid; other site 469383010026 ABC transporter signature motif; other site 469383010027 Walker B; other site 469383010028 D-loop; other site 469383010029 H-loop/switch region; other site 469383010030 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 469383010031 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383010032 Walker A/P-loop; other site 469383010033 ATP binding site [chemical binding]; other site 469383010034 Q-loop/lid; other site 469383010035 ABC transporter signature motif; other site 469383010036 Walker B; other site 469383010037 D-loop; other site 469383010038 H-loop/switch region; other site 469383010039 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 469383010040 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 469383010041 alpha-gamma subunit interface [polypeptide binding]; other site 469383010042 beta-gamma subunit interface [polypeptide binding]; other site 469383010043 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 469383010044 alpha-beta subunit interface [polypeptide binding]; other site 469383010045 urease subunit alpha; Reviewed; Region: ureC; PRK13206 469383010046 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383010047 active site 469383010048 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 469383010049 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383010050 UreD urease accessory protein; Region: UreD; cl00530 469383010051 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 469383010052 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383010053 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 469383010054 acyl-activating enzyme (AAE) consensus motif; other site 469383010055 putative AMP binding site [chemical binding]; other site 469383010056 putative active site [active] 469383010057 putative CoA binding site [chemical binding]; other site 469383010058 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 469383010059 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 469383010060 active site 469383010061 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 469383010062 protein binding site [polypeptide binding]; other site 469383010063 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 469383010064 putative substrate binding region [chemical binding]; other site 469383010065 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 469383010066 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 469383010067 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 469383010068 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 469383010069 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 469383010070 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 469383010071 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 469383010072 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 469383010073 catalytic residue [active] 469383010074 putative FPP diphosphate binding site; other site 469383010075 putative FPP binding hydrophobic cleft; other site 469383010076 dimer interface [polypeptide binding]; other site 469383010077 putative IPP diphosphate binding site; other site 469383010078 ribosome recycling factor; Reviewed; Region: frr; PRK00083 469383010079 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 469383010080 hinge region; other site 469383010081 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 469383010082 putative nucleotide binding site [chemical binding]; other site 469383010083 uridine monophosphate binding site [chemical binding]; other site 469383010084 homohexameric interface [polypeptide binding]; other site 469383010085 elongation factor Ts; Reviewed; Region: tsf; PRK12332 469383010086 UBA/TS-N domain; Region: UBA; pfam00627 469383010087 Elongation factor TS; Region: EF_TS; pfam00889 469383010088 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 469383010089 rRNA interaction site [nucleotide binding]; other site 469383010090 S8 interaction site; other site 469383010091 putative laminin-1 binding site; other site 469383010092 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 469383010093 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469383010094 RNA binding surface [nucleotide binding]; other site 469383010095 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 469383010096 active site 469383010097 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 469383010098 lipoprotein signal peptidase; Provisional; Region: PRK14787 469383010099 YGGT family; Region: YGGT; pfam02325 469383010100 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 469383010101 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 469383010102 Protein of unknown function (DUF552); Region: DUF552; pfam04472 469383010103 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 469383010104 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383010105 catalytic residue [active] 469383010106 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 469383010107 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 469383010108 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 469383010109 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 469383010110 metal binding triad [ion binding]; metal-binding site 469383010111 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 469383010112 active site 469383010113 PQQ-like domain; Region: PQQ_2; pfam13360 469383010114 Trp docking motif [polypeptide binding]; other site 469383010115 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 469383010116 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 469383010117 substrate binding site [chemical binding]; other site 469383010118 glutamase interaction surface [polypeptide binding]; other site 469383010119 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 469383010120 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 469383010121 catalytic residues [active] 469383010122 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 469383010123 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 469383010124 putative active site [active] 469383010125 oxyanion strand; other site 469383010126 catalytic triad [active] 469383010127 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 469383010128 putative active site pocket [active] 469383010129 4-fold oligomerization interface [polypeptide binding]; other site 469383010130 metal binding residues [ion binding]; metal-binding site 469383010131 3-fold/trimer interface [polypeptide binding]; other site 469383010132 histidinol dehydrogenase; Region: hisD; TIGR00069 469383010133 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 469383010134 NAD binding site [chemical binding]; other site 469383010135 dimerization interface [polypeptide binding]; other site 469383010136 product binding site; other site 469383010137 substrate binding site [chemical binding]; other site 469383010138 zinc binding site [ion binding]; other site 469383010139 catalytic residues [active] 469383010140 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 469383010141 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 469383010142 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 469383010143 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 469383010144 dimer interface [polypeptide binding]; other site 469383010145 motif 1; other site 469383010146 active site 469383010147 motif 2; other site 469383010148 motif 3; other site 469383010149 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 469383010150 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 469383010151 hinge; other site 469383010152 active site 469383010153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 469383010154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383010155 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 469383010156 tartrate dehydrogenase; Provisional; Region: PRK08194 469383010157 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 469383010158 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 469383010159 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 469383010160 active site 469383010161 HIGH motif; other site 469383010162 dimer interface [polypeptide binding]; other site 469383010163 KMSKS motif; other site 469383010164 Transglycosylase; Region: Transgly; pfam00912 469383010165 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 469383010166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469383010167 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 469383010168 active site 469383010169 DNA binding site [nucleotide binding] 469383010170 argininosuccinate lyase; Provisional; Region: PRK00855 469383010171 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 469383010172 active sites [active] 469383010173 tetramer interface [polypeptide binding]; other site 469383010174 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 469383010175 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 469383010176 inhibitor-cofactor binding pocket; inhibition site 469383010177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383010178 catalytic residue [active] 469383010179 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 469383010180 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 469383010181 active site 469383010182 catalytic residues [active] 469383010183 metal binding site [ion binding]; metal-binding site 469383010184 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 469383010185 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 469383010186 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 469383010187 homodimer interface [polypeptide binding]; other site 469383010188 substrate-cofactor binding pocket; other site 469383010189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383010190 catalytic residue [active] 469383010191 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 469383010192 tartrate dehydrogenase; Region: TTC; TIGR02089 469383010193 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 469383010194 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 469383010195 substrate binding site [chemical binding]; other site 469383010196 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 469383010197 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 469383010198 substrate binding site [chemical binding]; other site 469383010199 ligand binding site [chemical binding]; other site 469383010200 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383010201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383010202 non-specific DNA binding site [nucleotide binding]; other site 469383010203 salt bridge; other site 469383010204 sequence-specific DNA binding site [nucleotide binding]; other site 469383010205 Cupin domain; Region: Cupin_2; pfam07883 469383010206 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 469383010207 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 469383010208 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 469383010209 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 469383010210 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 469383010211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383010212 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 469383010213 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 469383010214 2-isopropylmalate synthase; Validated; Region: PRK00915 469383010215 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 469383010216 active site 469383010217 catalytic residues [active] 469383010218 metal binding site [ion binding]; metal-binding site 469383010219 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 469383010220 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 469383010221 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 469383010222 ligand binding site [chemical binding]; other site 469383010223 NAD binding site [chemical binding]; other site 469383010224 dimerization interface [polypeptide binding]; other site 469383010225 catalytic site [active] 469383010226 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 469383010227 putative L-serine binding site [chemical binding]; other site 469383010228 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383010229 ketol-acid reductoisomerase; Provisional; Region: PRK05479 469383010230 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 469383010231 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 469383010232 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 469383010233 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383010234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383010235 S-adenosylmethionine binding site [chemical binding]; other site 469383010236 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 469383010237 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383010238 acyl-activating enzyme (AAE) consensus motif; other site 469383010239 active site 469383010240 AMP binding site [chemical binding]; other site 469383010241 CoA binding site [chemical binding]; other site 469383010242 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383010243 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 469383010244 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 469383010245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383010246 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 469383010247 substrate binding site [chemical binding]; other site 469383010248 oxyanion hole (OAH) forming residues; other site 469383010249 trimer interface [polypeptide binding]; other site 469383010250 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 469383010251 UbiA prenyltransferase family; Region: UbiA; pfam01040 469383010252 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383010253 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383010254 metal binding site [ion binding]; metal-binding site 469383010255 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383010256 metal binding site [ion binding]; metal-binding site 469383010257 substrate binding pocket [chemical binding]; other site 469383010258 substrate binding pocket [chemical binding]; other site 469383010259 MMPL family; Region: MMPL; pfam03176 469383010260 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 469383010261 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 469383010262 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 469383010263 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 469383010264 dimer interface [polypeptide binding]; other site 469383010265 tetramer interface [polypeptide binding]; other site 469383010266 PYR/PP interface [polypeptide binding]; other site 469383010267 TPP binding site [chemical binding]; other site 469383010268 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383010269 TPP-binding site [chemical binding]; other site 469383010270 chorismate binding enzyme; Region: Chorismate_bind; cl10555 469383010271 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 469383010272 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 469383010273 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 469383010274 putative valine binding site [chemical binding]; other site 469383010275 dimer interface [polypeptide binding]; other site 469383010276 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 469383010277 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 469383010278 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383010279 PYR/PP interface [polypeptide binding]; other site 469383010280 dimer interface [polypeptide binding]; other site 469383010281 TPP binding site [chemical binding]; other site 469383010282 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383010283 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 469383010284 TPP-binding site [chemical binding]; other site 469383010285 dimer interface [polypeptide binding]; other site 469383010286 DNA polymerase II large subunit; Provisional; Region: PRK14714 469383010287 RibD C-terminal domain; Region: RibD_C; cl17279 469383010288 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 469383010289 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 469383010290 GatB domain; Region: GatB_Yqey; smart00845 469383010291 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383010292 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 469383010293 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 469383010294 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 469383010295 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 469383010296 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 469383010297 homodimer interface [polypeptide binding]; other site 469383010298 NADP binding site [chemical binding]; other site 469383010299 substrate binding site [chemical binding]; other site 469383010300 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 469383010301 Part of AAA domain; Region: AAA_19; pfam13245 469383010302 Family description; Region: UvrD_C_2; pfam13538 469383010303 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383010304 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 469383010305 NodB motif; other site 469383010306 active site 469383010307 catalytic site [active] 469383010308 metal binding site [ion binding]; metal-binding site 469383010309 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 469383010310 Ligand binding site; other site 469383010311 Putative Catalytic site; other site 469383010312 DXD motif; other site 469383010313 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 469383010314 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 469383010315 trimer interface [polypeptide binding]; other site 469383010316 active site 469383010317 substrate binding site [chemical binding]; other site 469383010318 CoA binding site [chemical binding]; other site 469383010319 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 469383010320 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 469383010321 dimer interface [polypeptide binding]; other site 469383010322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383010323 catalytic residue [active] 469383010324 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 469383010325 adenosine deaminase; Provisional; Region: PRK09358 469383010326 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 469383010327 active site 469383010328 Predicted GTPases [General function prediction only]; Region: COG1162 469383010329 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 469383010330 GTPase/Zn-binding domain interface [polypeptide binding]; other site 469383010331 GTP/Mg2+ binding site [chemical binding]; other site 469383010332 G4 box; other site 469383010333 G5 box; other site 469383010334 G1 box; other site 469383010335 Switch I region; other site 469383010336 G2 box; other site 469383010337 G3 box; other site 469383010338 Switch II region; other site 469383010339 Predicted acetyltransferase [General function prediction only]; Region: COG3153 469383010340 Predicted ATPase [General function prediction only]; Region: COG4637 469383010341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383010342 Walker A/P-loop; other site 469383010343 ATP binding site [chemical binding]; other site 469383010344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383010345 Walker B; other site 469383010346 D-loop; other site 469383010347 H-loop/switch region; other site 469383010348 Transcriptional regulator; Region: Rrf2; pfam02082 469383010349 Predicted integral membrane protein [Function unknown]; Region: COG5652 469383010350 HDOD domain; Region: HDOD; pfam08668 469383010351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383010352 Zn2+ binding site [ion binding]; other site 469383010353 Mg2+ binding site [ion binding]; other site 469383010354 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383010355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383010356 DNA binding residues [nucleotide binding] 469383010357 dimerization interface [polypeptide binding]; other site 469383010358 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 469383010359 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 469383010360 HIGH motif; other site 469383010361 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 469383010362 active site 469383010363 KMSKS motif; other site 469383010364 endonuclease IV; Provisional; Region: PRK01060 469383010365 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 469383010366 AP (apurinic/apyrimidinic) site pocket; other site 469383010367 DNA interaction; other site 469383010368 Metal-binding active site; metal-binding site 469383010369 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 469383010370 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 469383010371 active site 469383010372 PHP Thumb interface [polypeptide binding]; other site 469383010373 metal binding site [ion binding]; metal-binding site 469383010374 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 469383010375 generic binding surface II; other site 469383010376 generic binding surface I; other site 469383010377 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 469383010378 argininosuccinate synthase; Provisional; Region: PRK13820 469383010379 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 469383010380 ANP binding site [chemical binding]; other site 469383010381 Substrate Binding Site II [chemical binding]; other site 469383010382 Substrate Binding Site I [chemical binding]; other site 469383010383 Response regulator receiver domain; Region: Response_reg; pfam00072 469383010384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383010385 active site 469383010386 phosphorylation site [posttranslational modification] 469383010387 intermolecular recognition site; other site 469383010388 dimerization interface [polypeptide binding]; other site 469383010389 acetylornithine aminotransferase; Provisional; Region: PRK02627 469383010390 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383010391 inhibitor-cofactor binding pocket; inhibition site 469383010392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383010393 catalytic residue [active] 469383010394 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 469383010395 feedback inhibition sensing region; other site 469383010396 homohexameric interface [polypeptide binding]; other site 469383010397 nucleotide binding site [chemical binding]; other site 469383010398 N-acetyl-L-glutamate binding site [chemical binding]; other site 469383010399 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 469383010400 heterotetramer interface [polypeptide binding]; other site 469383010401 active site pocket [active] 469383010402 cleavage site 469383010403 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 469383010404 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 469383010405 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 469383010406 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 469383010407 putative tRNA-binding site [nucleotide binding]; other site 469383010408 B3/4 domain; Region: B3_4; pfam03483 469383010409 tRNA synthetase B5 domain; Region: B5; smart00874 469383010410 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 469383010411 dimer interface [polypeptide binding]; other site 469383010412 motif 1; other site 469383010413 motif 3; other site 469383010414 motif 2; other site 469383010415 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 469383010416 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 469383010417 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 469383010418 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 469383010419 dimer interface [polypeptide binding]; other site 469383010420 motif 1; other site 469383010421 active site 469383010422 motif 2; other site 469383010423 motif 3; other site 469383010424 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 469383010425 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 469383010426 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 469383010427 23S rRNA binding site [nucleotide binding]; other site 469383010428 L21 binding site [polypeptide binding]; other site 469383010429 L13 binding site [polypeptide binding]; other site 469383010430 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 469383010431 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 469383010432 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 469383010433 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 469383010434 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 469383010435 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 469383010436 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 469383010437 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 469383010438 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 469383010439 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 469383010440 active site 469383010441 dimer interface [polypeptide binding]; other site 469383010442 motif 1; other site 469383010443 motif 2; other site 469383010444 motif 3; other site 469383010445 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 469383010446 anticodon binding site; other site 469383010447 MMPL family; Region: MMPL; pfam03176 469383010448 MMPL family; Region: MMPL; pfam03176 469383010449 Cupin domain; Region: Cupin_2; cl17218 469383010450 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 469383010451 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383010452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383010453 DNA-binding site [nucleotide binding]; DNA binding site 469383010454 FCD domain; Region: FCD; pfam07729 469383010455 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 469383010456 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 469383010457 putative active site [active] 469383010458 metal binding site [ion binding]; metal-binding site 469383010459 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383010460 FAD binding domain; Region: FAD_binding_4; pfam01565 469383010461 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 469383010462 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 469383010463 Catalytic site [active] 469383010464 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 469383010465 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 469383010466 dimer interface [polypeptide binding]; other site 469383010467 decamer (pentamer of dimers) interface [polypeptide binding]; other site 469383010468 catalytic triad [active] 469383010469 Acylphosphatase; Region: Acylphosphatase; pfam00708 469383010470 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 469383010471 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383010472 active site 469383010473 imidazolonepropionase; Region: hutI; TIGR01224 469383010474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383010475 active site 469383010476 urocanate hydratase; Provisional; Region: PRK05414 469383010477 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 469383010478 active sites [active] 469383010479 tetramer interface [polypeptide binding]; other site 469383010480 uncharacterized phage protein; Region: phage_xxxx; TIGR02642 469383010481 Predicted ATPase [General function prediction only]; Region: COG3899 469383010482 AAA ATPase domain; Region: AAA_16; pfam13191 469383010483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383010484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383010485 DNA binding residues [nucleotide binding] 469383010486 dimerization interface [polypeptide binding]; other site 469383010487 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383010488 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469383010489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383010490 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 469383010491 Walker A/P-loop; other site 469383010492 ATP binding site [chemical binding]; other site 469383010493 Q-loop/lid; other site 469383010494 ABC transporter signature motif; other site 469383010495 Walker B; other site 469383010496 D-loop; other site 469383010497 H-loop/switch region; other site 469383010498 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383010499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383010500 Walker A/P-loop; other site 469383010501 ATP binding site [chemical binding]; other site 469383010502 Q-loop/lid; other site 469383010503 ABC transporter signature motif; other site 469383010504 Walker B; other site 469383010505 D-loop; other site 469383010506 H-loop/switch region; other site 469383010507 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 469383010508 FtsX-like permease family; Region: FtsX; pfam02687 469383010509 FtsX-like permease family; Region: FtsX; pfam02687 469383010510 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 469383010511 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 469383010512 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 469383010513 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 469383010514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383010515 dimerization interface [polypeptide binding]; other site 469383010516 putative DNA binding site [nucleotide binding]; other site 469383010517 putative Zn2+ binding site [ion binding]; other site 469383010518 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383010519 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 469383010520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 469383010521 DNA binding residues [nucleotide binding] 469383010522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383010523 S-adenosylmethionine binding site [chemical binding]; other site 469383010524 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469383010525 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 469383010526 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 469383010527 RNA/DNA hybrid binding site [nucleotide binding]; other site 469383010528 active site 469383010529 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 469383010530 elongation factor G; Reviewed; Region: PRK12740 469383010531 G1 box; other site 469383010532 putative GEF interaction site [polypeptide binding]; other site 469383010533 GTP/Mg2+ binding site [chemical binding]; other site 469383010534 Switch I region; other site 469383010535 G2 box; other site 469383010536 G3 box; other site 469383010537 Switch II region; other site 469383010538 G4 box; other site 469383010539 G5 box; other site 469383010540 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 469383010541 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 469383010542 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 469383010543 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 469383010544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383010545 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469383010546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383010547 DNA binding residues [nucleotide binding] 469383010548 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 469383010549 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 469383010550 active site 469383010551 DNA binding site [nucleotide binding] 469383010552 Int/Topo IB signature motif; other site 469383010553 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 469383010554 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383010555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 469383010556 Uncharacterized conserved protein [Function unknown]; Region: COG5663 469383010557 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 469383010558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383010559 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383010560 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 469383010561 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 469383010562 dimer interface [polypeptide binding]; other site 469383010563 substrate binding site [chemical binding]; other site 469383010564 ATP binding site [chemical binding]; other site 469383010565 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 469383010566 DNA protecting protein DprA; Region: dprA; TIGR00732 469383010567 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 469383010568 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 469383010569 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 469383010570 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 469383010571 hypothetical protein; Reviewed; Region: PRK12497 469383010572 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 469383010573 RNA/DNA hybrid binding site [nucleotide binding]; other site 469383010574 active site 469383010575 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 469383010576 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 469383010577 Catalytic site [active] 469383010578 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 469383010579 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 469383010580 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 469383010581 RimM N-terminal domain; Region: RimM; pfam01782 469383010582 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 469383010583 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 469383010584 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 469383010585 signal recognition particle protein; Provisional; Region: PRK10867 469383010586 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 469383010587 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 469383010588 P loop; other site 469383010589 GTP binding site [chemical binding]; other site 469383010590 Signal peptide binding domain; Region: SRP_SPB; pfam02978 469383010591 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 469383010592 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 469383010593 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 469383010594 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 469383010595 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 469383010596 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383010597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383010598 Coenzyme A binding pocket [chemical binding]; other site 469383010599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383010600 Walker A/P-loop; other site 469383010601 ATP binding site [chemical binding]; other site 469383010602 Q-loop/lid; other site 469383010603 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 469383010604 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 469383010605 ABC transporter signature motif; other site 469383010606 Walker B; other site 469383010607 D-loop; other site 469383010608 H-loop/switch region; other site 469383010609 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 469383010610 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 469383010611 dimerization interface [polypeptide binding]; other site 469383010612 active site 469383010613 metal binding site [ion binding]; metal-binding site 469383010614 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 469383010615 dsRNA binding site [nucleotide binding]; other site 469383010616 acyl carrier protein; Provisional; Region: acpP; PRK00982 469383010617 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 469383010618 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 469383010619 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 469383010620 acyl-CoA synthetase; Validated; Region: PRK07788 469383010621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383010622 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 469383010623 acyl-activating enzyme (AAE) consensus motif; other site 469383010624 putative AMP binding site [chemical binding]; other site 469383010625 putative active site [active] 469383010626 putative CoA binding site [chemical binding]; other site 469383010627 RmuC family; Region: RmuC; pfam02646 469383010628 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 469383010629 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 469383010630 active site 469383010631 (T/H)XGH motif; other site 469383010632 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 469383010633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383010634 S-adenosylmethionine binding site [chemical binding]; other site 469383010635 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 469383010636 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 469383010637 ssDNA binding site; other site 469383010638 generic binding surface II; other site 469383010639 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383010640 ATP binding site [chemical binding]; other site 469383010641 putative Mg++ binding site [ion binding]; other site 469383010642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383010643 nucleotide binding region [chemical binding]; other site 469383010644 ATP-binding site [chemical binding]; other site 469383010645 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 469383010646 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 469383010647 DAK2 domain; Region: Dak2; pfam02734 469383010648 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 469383010649 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 469383010650 homopentamer interface [polypeptide binding]; other site 469383010651 active site 469383010652 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 469383010653 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 469383010654 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 469383010655 dimerization interface [polypeptide binding]; other site 469383010656 active site 469383010657 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 469383010658 Lumazine binding domain; Region: Lum_binding; pfam00677 469383010659 Lumazine binding domain; Region: Lum_binding; pfam00677 469383010660 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 469383010661 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 469383010662 catalytic motif [active] 469383010663 Zn binding site [ion binding]; other site 469383010664 RibD C-terminal domain; Region: RibD_C; cl17279 469383010665 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 469383010666 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 469383010667 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 469383010668 Ligand binding site; other site 469383010669 Putative Catalytic site; other site 469383010670 DXD motif; other site 469383010671 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383010672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383010673 S-adenosylmethionine binding site [chemical binding]; other site 469383010674 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 469383010675 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 469383010676 oligomeric interface; other site 469383010677 putative active site [active] 469383010678 homodimer interface [polypeptide binding]; other site 469383010679 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 469383010680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383010681 FtsX-like permease family; Region: FtsX; pfam02687 469383010682 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 469383010683 FtsX-like permease family; Region: FtsX; pfam02687 469383010684 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383010685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383010686 Walker A/P-loop; other site 469383010687 ATP binding site [chemical binding]; other site 469383010688 Q-loop/lid; other site 469383010689 ABC transporter signature motif; other site 469383010690 Walker B; other site 469383010691 D-loop; other site 469383010692 H-loop/switch region; other site 469383010693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383010694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383010695 active site 469383010696 phosphorylation site [posttranslational modification] 469383010697 intermolecular recognition site; other site 469383010698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383010699 DNA binding residues [nucleotide binding] 469383010700 Histidine kinase; Region: HisKA_3; pfam07730 469383010701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383010702 ATP binding site [chemical binding]; other site 469383010703 Mg2+ binding site [ion binding]; other site 469383010704 G-X-G motif; other site 469383010705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383010706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383010707 active site 469383010708 phosphorylation site [posttranslational modification] 469383010709 intermolecular recognition site; other site 469383010710 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 469383010711 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 469383010712 substrate binding site [chemical binding]; other site 469383010713 hexamer interface [polypeptide binding]; other site 469383010714 metal binding site [ion binding]; metal-binding site 469383010715 DNA polymerase II large subunit; Provisional; Region: PRK14714 469383010716 16S rRNA methyltransferase B; Provisional; Region: PRK14902 469383010717 NusB family; Region: NusB; pfam01029 469383010718 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 469383010719 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 469383010720 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 469383010721 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 469383010722 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 469383010723 putative active site [active] 469383010724 substrate binding site [chemical binding]; other site 469383010725 putative cosubstrate binding site; other site 469383010726 catalytic site [active] 469383010727 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 469383010728 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 469383010729 active site 469383010730 catalytic residues [active] 469383010731 metal binding site [ion binding]; metal-binding site 469383010732 primosome assembly protein PriA; Validated; Region: PRK05580 469383010733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383010734 ATP binding site [chemical binding]; other site 469383010735 putative Mg++ binding site [ion binding]; other site 469383010736 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 469383010737 helicase superfamily c-terminal domain; Region: HELICc; smart00490 469383010738 Bacterial PH domain; Region: DUF304; pfam03703 469383010739 S-adenosylmethionine synthetase; Validated; Region: PRK05250 469383010740 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 469383010741 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 469383010742 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 469383010743 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 469383010744 GTP-binding protein Der; Reviewed; Region: PRK00093 469383010745 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 469383010746 G1 box; other site 469383010747 GTP/Mg2+ binding site [chemical binding]; other site 469383010748 Switch I region; other site 469383010749 G2 box; other site 469383010750 Switch II region; other site 469383010751 G3 box; other site 469383010752 G4 box; other site 469383010753 G5 box; other site 469383010754 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 469383010755 G1 box; other site 469383010756 GTP/Mg2+ binding site [chemical binding]; other site 469383010757 Switch I region; other site 469383010758 G2 box; other site 469383010759 G3 box; other site 469383010760 Switch II region; other site 469383010761 G4 box; other site 469383010762 G5 box; other site 469383010763 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 469383010764 putative active site [active] 469383010765 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 469383010766 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 469383010767 cytidylate kinase; Provisional; Region: cmk; PRK00023 469383010768 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 469383010769 CMP-binding site; other site 469383010770 The sites determining sugar specificity; other site 469383010771 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 469383010772 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 469383010773 hinge; other site 469383010774 active site 469383010775 prephenate dehydrogenase; Validated; Region: PRK06545 469383010776 prephenate dehydrogenase; Validated; Region: PRK08507 469383010777 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 469383010778 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 469383010779 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 469383010780 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 469383010781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383010782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383010783 homodimer interface [polypeptide binding]; other site 469383010784 catalytic residue [active] 469383010785 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 469383010786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383010787 ATP binding site [chemical binding]; other site 469383010788 putative Mg++ binding site [ion binding]; other site 469383010789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383010790 nucleotide binding region [chemical binding]; other site 469383010791 ATP-binding site [chemical binding]; other site 469383010792 HRDC domain; Region: HRDC; pfam00570 469383010793 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 469383010794 homotrimer interaction site [polypeptide binding]; other site 469383010795 active site 469383010796 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 469383010797 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 469383010798 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469383010799 RNA binding surface [nucleotide binding]; other site 469383010800 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 469383010801 active site 469383010802 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 469383010803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383010804 FeS/SAM binding site; other site 469383010805 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 469383010806 ScpA/B protein; Region: ScpA_ScpB; cl00598 469383010807 Domain of unknown function (DUF385); Region: DUF385; cl04387 469383010808 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 469383010809 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 469383010810 active site 469383010811 HIGH motif; other site 469383010812 dimer interface [polypeptide binding]; other site 469383010813 KMSKS motif; other site 469383010814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383010815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383010816 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 469383010817 Cytochrome P450; Region: p450; cl12078 469383010818 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383010819 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 469383010820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383010821 catalytic residue [active] 469383010822 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 469383010823 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 469383010824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383010825 catalytic residue [active] 469383010826 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 469383010827 lipoyl attachment site [posttranslational modification]; other site 469383010828 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 469383010829 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 469383010830 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 469383010831 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 469383010832 nucleotide binding site [chemical binding]; other site 469383010833 SulA interaction site; other site 469383010834 cell division protein FtsQ; Provisional; Region: PRK05529 469383010835 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 469383010836 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 469383010837 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 469383010838 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469383010839 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 469383010840 putative active site [active] 469383010841 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383010842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383010843 active site 469383010844 phosphorylation site [posttranslational modification] 469383010845 intermolecular recognition site; other site 469383010846 dimerization interface [polypeptide binding]; other site 469383010847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383010848 DNA binding residues [nucleotide binding] 469383010849 2TM domain; Region: 2TM; pfam13239 469383010850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383010851 2TM domain; Region: 2TM; pfam13239 469383010852 Histidine kinase; Region: HisKA_3; pfam07730 469383010853 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383010854 ATP binding site [chemical binding]; other site 469383010855 Mg2+ binding site [ion binding]; other site 469383010856 G-X-G motif; other site 469383010857 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 469383010858 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 469383010859 putative di-iron ligands [ion binding]; other site 469383010860 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383010861 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 469383010862 Walker A/P-loop; other site 469383010863 ATP binding site [chemical binding]; other site 469383010864 Q-loop/lid; other site 469383010865 ABC transporter signature motif; other site 469383010866 Walker B; other site 469383010867 D-loop; other site 469383010868 H-loop/switch region; other site 469383010869 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 469383010870 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 469383010871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383010872 Histidine kinase; Region: HisKA_3; pfam07730 469383010873 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383010874 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383010875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383010876 active site 469383010877 phosphorylation site [posttranslational modification] 469383010878 intermolecular recognition site; other site 469383010879 dimerization interface [polypeptide binding]; other site 469383010880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383010881 DNA binding residues [nucleotide binding] 469383010882 dimerization interface [polypeptide binding]; other site 469383010883 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 469383010884 oxyanion hole [active] 469383010885 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 469383010886 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 469383010887 active site 469383010888 homodimer interface [polypeptide binding]; other site 469383010889 cell division protein FtsW; Region: ftsW; TIGR02614 469383010890 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 469383010891 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469383010892 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469383010893 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 469383010894 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 469383010895 Mg++ binding site [ion binding]; other site 469383010896 putative catalytic motif [active] 469383010897 putative substrate binding site [chemical binding]; other site 469383010898 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 469383010899 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 469383010900 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469383010901 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469383010902 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 469383010903 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469383010904 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469383010905 MraW methylase family; Region: Methyltransf_5; cl17771 469383010906 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 469383010907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 469383010908 MraZ protein; Region: MraZ; pfam02381 469383010909 MraZ protein; Region: MraZ; pfam02381 469383010910 Nitronate monooxygenase; Region: NMO; pfam03060 469383010911 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 469383010912 FMN binding site [chemical binding]; other site 469383010913 substrate binding site [chemical binding]; other site 469383010914 putative catalytic residue [active] 469383010915 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 469383010916 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 469383010917 Type II/IV secretion system protein; Region: T2SE; pfam00437 469383010918 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 469383010919 ATP binding site [chemical binding]; other site 469383010920 Walker A motif; other site 469383010921 hexamer interface [polypeptide binding]; other site 469383010922 Walker B motif; other site 469383010923 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 469383010924 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 469383010925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 469383010926 Protein of unknown function (DUF489); Region: DUF489; cl01097 469383010927 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 469383010928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383010929 Zn2+ binding site [ion binding]; other site 469383010930 Mg2+ binding site [ion binding]; other site 469383010931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383010932 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383010933 Mg2+ binding site [ion binding]; other site 469383010934 G-X-G motif; other site 469383010935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383010936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383010937 active site 469383010938 phosphorylation site [posttranslational modification] 469383010939 intermolecular recognition site; other site 469383010940 dimerization interface [polypeptide binding]; other site 469383010941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383010942 DNA binding site [nucleotide binding] 469383010943 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 469383010944 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 469383010945 MOSC domain; Region: MOSC; pfam03473 469383010946 Family description; Region: VCBS; pfam13517 469383010947 Family description; Region: VCBS; pfam13517 469383010948 Family description; Region: VCBS; pfam13517 469383010949 Family description; Region: VCBS; pfam13517 469383010950 Family description; Region: VCBS; pfam13517 469383010951 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 469383010952 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 469383010953 RNA binding site [nucleotide binding]; other site 469383010954 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 469383010955 Walker A motif; other site 469383010956 ATP binding site [chemical binding]; other site 469383010957 Walker B motif; other site 469383010958 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 469383010959 active site 469383010960 intersubunit interactions; other site 469383010961 catalytic residue [active] 469383010962 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 469383010963 dihydropteroate synthase; Region: DHPS; TIGR01496 469383010964 substrate binding pocket [chemical binding]; other site 469383010965 dimer interface [polypeptide binding]; other site 469383010966 inhibitor binding site; inhibition site 469383010967 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 469383010968 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 469383010969 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 469383010970 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 469383010971 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 469383010972 Walker A/P-loop; other site 469383010973 ATP binding site [chemical binding]; other site 469383010974 Q-loop/lid; other site 469383010975 ABC transporter signature motif; other site 469383010976 Walker B; other site 469383010977 D-loop; other site 469383010978 H-loop/switch region; other site 469383010979 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 469383010980 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 469383010981 Walker A/P-loop; other site 469383010982 ATP binding site [chemical binding]; other site 469383010983 Q-loop/lid; other site 469383010984 ABC transporter signature motif; other site 469383010985 Walker B; other site 469383010986 D-loop; other site 469383010987 H-loop/switch region; other site 469383010988 Cobalt transport protein; Region: CbiQ; cl00463 469383010989 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 469383010990 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 469383010991 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 469383010992 active site 469383010993 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 469383010994 transcription termination factor Rho; Provisional; Region: PRK12678 469383010995 pyruvate dehydrogenase; Provisional; Region: PRK06546 469383010996 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 469383010997 PYR/PP interface [polypeptide binding]; other site 469383010998 tetramer interface [polypeptide binding]; other site 469383010999 dimer interface [polypeptide binding]; other site 469383011000 TPP binding site [chemical binding]; other site 469383011001 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383011002 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383011003 TPP-binding site [chemical binding]; other site 469383011004 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 469383011005 active site 469383011006 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383011007 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 469383011008 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383011009 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383011010 Walker A/P-loop; other site 469383011011 ATP binding site [chemical binding]; other site 469383011012 Q-loop/lid; other site 469383011013 ABC transporter signature motif; other site 469383011014 Walker B; other site 469383011015 D-loop; other site 469383011016 H-loop/switch region; other site 469383011017 NMT1/THI5 like; Region: NMT1; pfam09084 469383011018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 469383011019 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 469383011020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469383011021 substrate binding pocket [chemical binding]; other site 469383011022 membrane-bound complex binding site; other site 469383011023 hinge residues; other site 469383011024 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 469383011025 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 469383011026 active site 469383011027 dimer interface [polypeptide binding]; other site 469383011028 non-prolyl cis peptide bond; other site 469383011029 insertion regions; other site 469383011030 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 469383011031 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469383011032 substrate binding pocket [chemical binding]; other site 469383011033 membrane-bound complex binding site; other site 469383011034 hinge residues; other site 469383011035 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 469383011036 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383011037 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383011038 Walker A/P-loop; other site 469383011039 ATP binding site [chemical binding]; other site 469383011040 Q-loop/lid; other site 469383011041 ABC transporter signature motif; other site 469383011042 Walker B; other site 469383011043 D-loop; other site 469383011044 H-loop/switch region; other site 469383011045 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383011046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011047 dimer interface [polypeptide binding]; other site 469383011048 conserved gate region; other site 469383011049 putative PBP binding loops; other site 469383011050 ABC-ATPase subunit interface; other site 469383011051 Secretory lipase; Region: LIP; pfam03583 469383011052 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 469383011053 Uncharacterized conserved protein [Function unknown]; Region: COG2128 469383011054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383011055 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383011056 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 469383011057 ABC1 family; Region: ABC1; pfam03109 469383011058 serine/threonine protein kinase; Provisional; Region: PRK14879 469383011059 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 469383011060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383011061 Zn2+ binding site [ion binding]; other site 469383011062 Mg2+ binding site [ion binding]; other site 469383011063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383011064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383011065 DNA binding residues [nucleotide binding] 469383011066 dimerization interface [polypeptide binding]; other site 469383011067 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 469383011068 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383011069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383011070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383011071 non-specific DNA binding site [nucleotide binding]; other site 469383011072 salt bridge; other site 469383011073 sequence-specific DNA binding site [nucleotide binding]; other site 469383011074 Cupin domain; Region: Cupin_2; pfam07883 469383011075 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 469383011076 active site 469383011077 intersubunit interface [polypeptide binding]; other site 469383011078 catalytic residue [active] 469383011079 Uncharacterized conserved protein [Function unknown]; Region: COG1262 469383011080 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 469383011081 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 469383011082 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 469383011083 nucleotide binding site [chemical binding]; other site 469383011084 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383011085 MarR family; Region: MarR_2; pfam12802 469383011086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383011087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383011088 putative substrate translocation pore; other site 469383011089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383011090 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 469383011091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383011092 substrate binding site [chemical binding]; other site 469383011093 oxyanion hole (OAH) forming residues; other site 469383011094 trimer interface [polypeptide binding]; other site 469383011095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383011096 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383011097 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 469383011098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383011099 RibD C-terminal domain; Region: RibD_C; cl17279 469383011100 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 469383011101 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 469383011102 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383011103 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383011104 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383011105 active site 469383011106 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 469383011107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383011108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383011109 DNA binding site [nucleotide binding] 469383011110 domain linker motif; other site 469383011111 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383011112 dimerization interface [polypeptide binding]; other site 469383011113 ligand binding site [chemical binding]; other site 469383011114 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383011115 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383011116 active site 469383011117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383011118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383011119 short chain dehydrogenase; Provisional; Region: PRK06197 469383011120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383011121 NAD(P) binding site [chemical binding]; other site 469383011122 active site 469383011123 REDY-like protein HapK; Region: HapK; pfam11639 469383011124 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 469383011125 active site 469383011126 catalytic triad [active] 469383011127 oxyanion hole [active] 469383011128 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 469383011129 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 469383011130 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 469383011131 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383011132 Cupin domain; Region: Cupin_2; cl17218 469383011133 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 469383011134 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383011135 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383011136 active site 469383011137 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 469383011138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383011139 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 469383011140 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383011141 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383011142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383011143 Walker A/P-loop; other site 469383011144 ATP binding site [chemical binding]; other site 469383011145 Q-loop/lid; other site 469383011146 ABC transporter signature motif; other site 469383011147 Walker B; other site 469383011148 D-loop; other site 469383011149 H-loop/switch region; other site 469383011150 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383011151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011152 dimer interface [polypeptide binding]; other site 469383011153 conserved gate region; other site 469383011154 putative PBP binding loops; other site 469383011155 ABC-ATPase subunit interface; other site 469383011156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011157 putative PBP binding loops; other site 469383011158 ABC-ATPase subunit interface; other site 469383011159 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383011160 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 469383011161 active site 469383011162 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383011163 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383011164 Cupin domain; Region: Cupin_2; pfam07883 469383011165 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 469383011166 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 469383011167 XdhC Rossmann domain; Region: XdhC_C; pfam13478 469383011168 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 469383011169 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 469383011170 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 469383011171 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 469383011172 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 469383011173 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 469383011174 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 469383011175 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 469383011176 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 469383011177 lipid-transfer protein; Provisional; Region: PRK07855 469383011178 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 469383011179 active site 469383011180 AAA domain; Region: AAA_14; pfam13173 469383011181 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 469383011182 tyramine oxidase; Provisional; Region: tynA; PRK11504 469383011183 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 469383011184 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 469383011185 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 469383011186 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 469383011187 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 469383011188 metal binding site [ion binding]; metal-binding site 469383011189 dimer interface [polypeptide binding]; other site 469383011190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383011191 Predicted amidohydrolase [General function prediction only]; Region: COG0388 469383011192 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 469383011193 putative active site [active] 469383011194 catalytic triad [active] 469383011195 putative dimer interface [polypeptide binding]; other site 469383011196 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383011197 Amidase; Region: Amidase; cl11426 469383011198 Amidase; Region: Amidase; cl11426 469383011199 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383011200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383011201 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 469383011202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383011203 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 469383011204 acyl-activating enzyme (AAE) consensus motif; other site 469383011205 putative AMP binding site [chemical binding]; other site 469383011206 putative active site [active] 469383011207 putative CoA binding site [chemical binding]; other site 469383011208 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383011209 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383011210 ligand binding site [chemical binding]; other site 469383011211 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383011212 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383011213 NAD(P) binding site [chemical binding]; other site 469383011214 catalytic residues [active] 469383011215 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 469383011216 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 469383011217 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383011218 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383011219 NAD(P) binding site [chemical binding]; other site 469383011220 catalytic residues [active] 469383011221 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383011222 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383011223 TM-ABC transporter signature motif; other site 469383011224 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383011225 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383011226 Walker A/P-loop; other site 469383011227 ATP binding site [chemical binding]; other site 469383011228 Q-loop/lid; other site 469383011229 ABC transporter signature motif; other site 469383011230 Walker B; other site 469383011231 D-loop; other site 469383011232 H-loop/switch region; other site 469383011233 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383011234 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 469383011235 Predicted amidohydrolase [General function prediction only]; Region: COG0388 469383011236 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 469383011237 active site 469383011238 catalytic triad [active] 469383011239 dimer interface [polypeptide binding]; other site 469383011240 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383011241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 469383011242 DNA-binding site [nucleotide binding]; DNA binding site 469383011243 FCD domain; Region: FCD; pfam07729 469383011244 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383011245 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 469383011246 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383011247 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383011248 homotrimer interaction site [polypeptide binding]; other site 469383011249 putative active site [active] 469383011250 Cupin domain; Region: Cupin_2; cl17218 469383011251 Cupin domain; Region: Cupin_2; cl17218 469383011252 FAD binding domain; Region: FAD_binding_3; pfam01494 469383011253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383011254 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 469383011255 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 469383011256 classical (c) SDRs; Region: SDR_c; cd05233 469383011257 NAD(P) binding site [chemical binding]; other site 469383011258 active site 469383011259 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 469383011260 Amidohydrolase; Region: Amidohydro_2; pfam04909 469383011261 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383011262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383011263 DNA binding residues [nucleotide binding] 469383011264 dimerization interface [polypeptide binding]; other site 469383011265 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 469383011266 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 469383011267 ligand binding site [chemical binding]; other site 469383011268 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 469383011269 active site 469383011270 catalytic site [active] 469383011271 Zn binding site [ion binding]; other site 469383011272 tetramer interface [polypeptide binding]; other site 469383011273 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383011274 Predicted amidohydrolase [General function prediction only]; Region: COG0388 469383011275 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 469383011276 active site 469383011277 catalytic triad [active] 469383011278 dimer interface [polypeptide binding]; other site 469383011279 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 469383011280 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 469383011281 Lipase (class 2); Region: Lipase_2; pfam01674 469383011282 Putative sensor; Region: Sensor; pfam13796 469383011283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383011284 Histidine kinase; Region: HisKA_3; pfam07730 469383011285 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383011286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383011287 active site 469383011288 phosphorylation site [posttranslational modification] 469383011289 intermolecular recognition site; other site 469383011290 dimerization interface [polypeptide binding]; other site 469383011291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383011292 DNA binding residues [nucleotide binding] 469383011293 dimerization interface [polypeptide binding]; other site 469383011294 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383011295 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 469383011296 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 469383011297 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383011298 DoxX; Region: DoxX; cl17842 469383011299 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 469383011300 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383011301 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 469383011302 amphipathic channel; other site 469383011303 Asn-Pro-Ala signature motifs; other site 469383011304 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 469383011305 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 469383011306 DAK2 domain; Region: Dak2; cl03685 469383011307 glycerol kinase; Provisional; Region: glpK; PRK00047 469383011308 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 469383011309 N- and C-terminal domain interface [polypeptide binding]; other site 469383011310 active site 469383011311 MgATP binding site [chemical binding]; other site 469383011312 catalytic site [active] 469383011313 metal binding site [ion binding]; metal-binding site 469383011314 putative homotetramer interface [polypeptide binding]; other site 469383011315 glycerol binding site [chemical binding]; other site 469383011316 homodimer interface [polypeptide binding]; other site 469383011317 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 469383011318 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 469383011319 dimerization domain swap beta strand [polypeptide binding]; other site 469383011320 regulatory protein interface [polypeptide binding]; other site 469383011321 active site 469383011322 regulatory phosphorylation site [posttranslational modification]; other site 469383011323 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 469383011324 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 469383011325 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 469383011326 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 469383011327 hypothetical protein; Provisional; Region: PRK10621 469383011328 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 469383011329 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 469383011330 oligomerisation interface [polypeptide binding]; other site 469383011331 mobile loop; other site 469383011332 roof hairpin; other site 469383011333 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 469383011334 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 469383011335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 469383011336 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 469383011337 Cupin domain; Region: Cupin_2; cl17218 469383011338 Cupin domain; Region: Cupin_2; cl17218 469383011339 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 469383011340 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 469383011341 classical (c) SDRs; Region: SDR_c; cd05233 469383011342 NAD(P) binding site [chemical binding]; other site 469383011343 active site 469383011344 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 469383011345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383011346 non-specific DNA binding site [nucleotide binding]; other site 469383011347 salt bridge; other site 469383011348 sequence-specific DNA binding site [nucleotide binding]; other site 469383011349 Cupin domain; Region: Cupin_2; pfam07883 469383011350 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383011351 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 469383011352 PYR/PP interface [polypeptide binding]; other site 469383011353 dimer interface [polypeptide binding]; other site 469383011354 TPP binding site [chemical binding]; other site 469383011355 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383011356 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383011357 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 469383011358 tetramer interface [polypeptide binding]; other site 469383011359 TPP-binding site [chemical binding]; other site 469383011360 heterodimer interface [polypeptide binding]; other site 469383011361 phosphorylation loop region [posttranslational modification] 469383011362 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 469383011363 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 469383011364 acyl-activating enzyme (AAE) consensus motif; other site 469383011365 putative AMP binding site [chemical binding]; other site 469383011366 putative active site [active] 469383011367 putative CoA binding site [chemical binding]; other site 469383011368 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383011369 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 469383011370 NAD(P) binding site [chemical binding]; other site 469383011371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383011372 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 469383011373 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383011374 classical (c) SDRs; Region: SDR_c; cd05233 469383011375 NAD(P) binding site [chemical binding]; other site 469383011376 active site 469383011377 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383011378 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383011379 Walker A/P-loop; other site 469383011380 ATP binding site [chemical binding]; other site 469383011381 Q-loop/lid; other site 469383011382 ABC transporter signature motif; other site 469383011383 Walker B; other site 469383011384 D-loop; other site 469383011385 H-loop/switch region; other site 469383011386 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383011387 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383011388 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383011389 TM-ABC transporter signature motif; other site 469383011390 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383011391 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383011392 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383011393 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383011394 TM-ABC transporter signature motif; other site 469383011395 YacP-like NYN domain; Region: NYN_YacP; cl01491 469383011396 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 469383011397 Cupin domain; Region: Cupin_2; cl17218 469383011398 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383011399 Amidohydrolase; Region: Amidohydro_4; pfam13147 469383011400 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383011401 active site 469383011402 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383011403 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 469383011404 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469383011405 putative active site [active] 469383011406 putative metal binding site [ion binding]; other site 469383011407 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469383011408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383011409 Walker A/P-loop; other site 469383011410 ATP binding site [chemical binding]; other site 469383011411 ABC transporter signature motif; other site 469383011412 Walker B; other site 469383011413 D-loop; other site 469383011414 H-loop/switch region; other site 469383011415 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469383011416 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 469383011417 DNA-binding site [nucleotide binding]; DNA binding site 469383011418 RNA-binding motif; other site 469383011419 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 469383011420 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383011421 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 469383011422 NAD(P) binding site [chemical binding]; other site 469383011423 catalytic residues [active] 469383011424 Peptidase family U32; Region: Peptidase_U32; cl03113 469383011425 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383011426 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383011427 Walker A/P-loop; other site 469383011428 ATP binding site [chemical binding]; other site 469383011429 Q-loop/lid; other site 469383011430 ABC transporter signature motif; other site 469383011431 Walker B; other site 469383011432 D-loop; other site 469383011433 H-loop/switch region; other site 469383011434 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383011435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011436 dimer interface [polypeptide binding]; other site 469383011437 conserved gate region; other site 469383011438 putative PBP binding loops; other site 469383011439 ABC-ATPase subunit interface; other site 469383011440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011441 dimer interface [polypeptide binding]; other site 469383011442 conserved gate region; other site 469383011443 putative PBP binding loops; other site 469383011444 ABC-ATPase subunit interface; other site 469383011445 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383011446 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383011447 alpha-galactosidase; Provisional; Region: PRK15076 469383011448 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 469383011449 NAD binding site [chemical binding]; other site 469383011450 sugar binding site [chemical binding]; other site 469383011451 divalent metal binding site [ion binding]; other site 469383011452 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 469383011453 dimer interface [polypeptide binding]; other site 469383011454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 469383011455 classical (c) SDRs; Region: SDR_c; cd05233 469383011456 NAD(P) binding site [chemical binding]; other site 469383011457 active site 469383011458 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383011459 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383011460 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383011461 HEPN domain; Region: HEPN; pfam05168 469383011462 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 469383011463 active site 469383011464 NTP binding site [chemical binding]; other site 469383011465 metal binding triad [ion binding]; metal-binding site 469383011466 antibiotic binding site [chemical binding]; other site 469383011467 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383011468 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 469383011469 dimer interface [polypeptide binding]; other site 469383011470 metal binding site [ion binding]; metal-binding site 469383011471 substrate binding site [chemical binding]; other site 469383011472 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383011473 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 469383011474 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383011475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383011476 DNA-binding site [nucleotide binding]; DNA binding site 469383011477 FCD domain; Region: FCD; pfam07729 469383011478 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383011479 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383011480 TM-ABC transporter signature motif; other site 469383011481 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383011482 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383011483 TM-ABC transporter signature motif; other site 469383011484 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383011485 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383011486 Walker A/P-loop; other site 469383011487 ATP binding site [chemical binding]; other site 469383011488 Q-loop/lid; other site 469383011489 ABC transporter signature motif; other site 469383011490 Walker B; other site 469383011491 D-loop; other site 469383011492 H-loop/switch region; other site 469383011493 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383011494 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383011495 Walker A/P-loop; other site 469383011496 ATP binding site [chemical binding]; other site 469383011497 Q-loop/lid; other site 469383011498 ABC transporter signature motif; other site 469383011499 Walker B; other site 469383011500 D-loop; other site 469383011501 H-loop/switch region; other site 469383011502 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 469383011503 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383011504 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 469383011505 Isochorismatase family; Region: Isochorismatase; pfam00857 469383011506 catalytic triad [active] 469383011507 conserved cis-peptide bond; other site 469383011508 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 469383011509 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 469383011510 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 469383011511 phosphate binding site [ion binding]; other site 469383011512 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383011513 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383011514 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383011515 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469383011516 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383011517 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 469383011518 active site 469383011519 catalytic residues [active] 469383011520 metal binding site [ion binding]; metal-binding site 469383011521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383011522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383011523 NAD(P) binding site [chemical binding]; other site 469383011524 active site 469383011525 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 469383011526 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 469383011527 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 469383011528 Protein of unknown function, DUF608; Region: DUF608; pfam04685 469383011529 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 469383011530 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383011531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011532 dimer interface [polypeptide binding]; other site 469383011533 conserved gate region; other site 469383011534 putative PBP binding loops; other site 469383011535 ABC-ATPase subunit interface; other site 469383011536 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383011537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011538 dimer interface [polypeptide binding]; other site 469383011539 conserved gate region; other site 469383011540 putative PBP binding loops; other site 469383011541 ABC-ATPase subunit interface; other site 469383011542 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383011543 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383011544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383011545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383011546 DNA binding site [nucleotide binding] 469383011547 domain linker motif; other site 469383011548 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383011549 dimerization interface [polypeptide binding]; other site 469383011550 ligand binding site [chemical binding]; other site 469383011551 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 469383011552 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 469383011553 hexamer (dimer of trimers) interface [polypeptide binding]; other site 469383011554 trimer interface [polypeptide binding]; other site 469383011555 substrate binding site [chemical binding]; other site 469383011556 Mn binding site [ion binding]; other site 469383011557 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 469383011558 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 469383011559 N- and C-terminal domain interface [polypeptide binding]; other site 469383011560 putative active site [active] 469383011561 MgATP binding site [chemical binding]; other site 469383011562 catalytic site [active] 469383011563 metal binding site [ion binding]; metal-binding site 469383011564 putative xylulose binding site [chemical binding]; other site 469383011565 putative homodimer interface [polypeptide binding]; other site 469383011566 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383011567 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383011568 Walker A/P-loop; other site 469383011569 ATP binding site [chemical binding]; other site 469383011570 Q-loop/lid; other site 469383011571 ABC transporter signature motif; other site 469383011572 Walker B; other site 469383011573 D-loop; other site 469383011574 H-loop/switch region; other site 469383011575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383011576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383011577 active site 469383011578 phosphorylation site [posttranslational modification] 469383011579 intermolecular recognition site; other site 469383011580 dimerization interface [polypeptide binding]; other site 469383011581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383011582 DNA binding residues [nucleotide binding] 469383011583 dimerization interface [polypeptide binding]; other site 469383011584 Histidine kinase; Region: HisKA_3; pfam07730 469383011585 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383011586 MMPL family; Region: MMPL; pfam03176 469383011587 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383011588 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 469383011589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383011590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383011591 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383011592 homotrimer interaction site [polypeptide binding]; other site 469383011593 putative active site [active] 469383011594 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 469383011595 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 469383011596 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 469383011597 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 469383011598 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 469383011599 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383011600 NAD(P) binding site [chemical binding]; other site 469383011601 catalytic residues [active] 469383011602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383011603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383011604 Phosphotransferase enzyme family; Region: APH; pfam01636 469383011605 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 469383011606 putative active site [active] 469383011607 putative substrate binding site [chemical binding]; other site 469383011608 ATP binding site [chemical binding]; other site 469383011609 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 469383011610 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383011611 dimer interface [polypeptide binding]; other site 469383011612 active site 469383011613 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383011614 classical (c) SDRs; Region: SDR_c; cd05233 469383011615 NAD(P) binding site [chemical binding]; other site 469383011616 active site 469383011617 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 469383011618 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 469383011619 [2Fe-2S] cluster binding site [ion binding]; other site 469383011620 Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848 469383011621 hydrophobic ligand binding site; other site 469383011622 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383011623 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383011624 ligand binding site [chemical binding]; other site 469383011625 4-coumarate--CoA ligase; Region: PLN02246 469383011626 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383011627 acyl-activating enzyme (AAE) consensus motif; other site 469383011628 AMP binding site [chemical binding]; other site 469383011629 active site 469383011630 CoA binding site [chemical binding]; other site 469383011631 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383011632 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 469383011633 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 469383011634 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 469383011635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383011636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383011637 active site 469383011638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383011639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383011640 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 469383011641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383011642 NAD(P) binding site [chemical binding]; other site 469383011643 active site 469383011644 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 469383011645 putative active site [active] 469383011646 putative catalytic site [active] 469383011647 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383011648 classical (c) SDRs; Region: SDR_c; cd05233 469383011649 NAD(P) binding site [chemical binding]; other site 469383011650 active site 469383011651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383011652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383011653 active site 469383011654 acetylornithine deacetylase; Provisional; Region: PRK06837 469383011655 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383011656 metal binding site [ion binding]; metal-binding site 469383011657 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383011658 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383011659 TM-ABC transporter signature motif; other site 469383011660 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383011661 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383011662 Walker A/P-loop; other site 469383011663 ATP binding site [chemical binding]; other site 469383011664 Q-loop/lid; other site 469383011665 ABC transporter signature motif; other site 469383011666 Walker B; other site 469383011667 D-loop; other site 469383011668 H-loop/switch region; other site 469383011669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383011670 Q-loop/lid; other site 469383011671 ABC transporter signature motif; other site 469383011672 Walker B; other site 469383011673 D-loop; other site 469383011674 H-loop/switch region; other site 469383011675 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383011676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383011677 NAD(P) binding site [chemical binding]; other site 469383011678 active site 469383011679 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383011680 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 469383011681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383011682 NAD(P) binding site [chemical binding]; other site 469383011683 active site 469383011684 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 469383011685 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 469383011686 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 469383011687 dimerization interface [polypeptide binding]; other site 469383011688 active site 469383011689 conserved repeat domain; Region: B_ant_repeat; TIGR01451 469383011690 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383011691 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383011692 D-cysteine desulfhydrase; Validated; Region: PRK03910 469383011693 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 469383011694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383011695 catalytic residue [active] 469383011696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383011697 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 469383011698 NAD(P) binding site [chemical binding]; other site 469383011699 active site 469383011700 Protein of unknown function (DUF419); Region: DUF419; pfam04237 469383011701 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 469383011702 amidase catalytic site [active] 469383011703 Zn binding residues [ion binding]; other site 469383011704 substrate binding site [chemical binding]; other site 469383011705 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 469383011706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383011707 S-adenosylmethionine binding site [chemical binding]; other site 469383011708 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 469383011709 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383011710 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383011711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383011712 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 469383011713 Walker A/P-loop; other site 469383011714 ATP binding site [chemical binding]; other site 469383011715 Q-loop/lid; other site 469383011716 ABC transporter signature motif; other site 469383011717 Walker B; other site 469383011718 D-loop; other site 469383011719 H-loop/switch region; other site 469383011720 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 469383011721 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383011722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383011723 putative DNA binding site [nucleotide binding]; other site 469383011724 putative Zn2+ binding site [ion binding]; other site 469383011725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383011726 non-specific DNA binding site [nucleotide binding]; other site 469383011727 salt bridge; other site 469383011728 sequence-specific DNA binding site [nucleotide binding]; other site 469383011729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383011730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383011731 non-specific DNA binding site [nucleotide binding]; other site 469383011732 salt bridge; other site 469383011733 sequence-specific DNA binding site [nucleotide binding]; other site 469383011734 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 469383011735 Zn binding site [ion binding]; other site 469383011736 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383011737 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383011738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383011739 putative DNA binding site [nucleotide binding]; other site 469383011740 dimerization interface [polypeptide binding]; other site 469383011741 putative Zn2+ binding site [ion binding]; other site 469383011742 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383011743 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383011744 NAD(P) binding site [chemical binding]; other site 469383011745 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383011746 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 469383011747 inhibitor-cofactor binding pocket; inhibition site 469383011748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383011749 catalytic residue [active] 469383011750 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 469383011751 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383011752 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383011753 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 469383011754 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383011755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383011756 DNA-binding site [nucleotide binding]; DNA binding site 469383011757 FCD domain; Region: FCD; pfam07729 469383011758 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 469383011759 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383011760 PYR/PP interface [polypeptide binding]; other site 469383011761 dimer interface [polypeptide binding]; other site 469383011762 TPP binding site [chemical binding]; other site 469383011763 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383011764 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 469383011765 TPP-binding site [chemical binding]; other site 469383011766 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383011767 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383011768 NAD(P) binding site [chemical binding]; other site 469383011769 catalytic residues [active] 469383011770 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 469383011771 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 469383011772 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383011773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383011774 sequence-specific DNA binding site [nucleotide binding]; other site 469383011775 salt bridge; other site 469383011776 Cupin domain; Region: Cupin_2; pfam07883 469383011777 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 469383011778 hypothetical protein; Provisional; Region: PRK11770 469383011779 Domain of unknown function (DUF307); Region: DUF307; pfam03733 469383011780 Domain of unknown function (DUF307); Region: DUF307; pfam03733 469383011781 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 469383011782 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 469383011783 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 469383011784 active site 469383011785 dimerization interface [polypeptide binding]; other site 469383011786 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 469383011787 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 469383011788 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 469383011789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383011790 substrate binding site [chemical binding]; other site 469383011791 oxyanion hole (OAH) forming residues; other site 469383011792 trimer interface [polypeptide binding]; other site 469383011793 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 469383011794 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 469383011795 active site residue [active] 469383011796 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 469383011797 active site residue [active] 469383011798 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383011799 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383011800 hypothetical protein; Provisional; Region: PRK08204 469383011801 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383011802 active site 469383011803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383011804 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383011805 putative substrate translocation pore; other site 469383011806 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 469383011807 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383011808 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 469383011809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 469383011810 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 469383011811 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383011812 catalytic loop [active] 469383011813 iron binding site [ion binding]; other site 469383011814 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 469383011815 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 469383011816 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 469383011817 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 469383011818 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 469383011819 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383011820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011821 dimer interface [polypeptide binding]; other site 469383011822 conserved gate region; other site 469383011823 ABC-ATPase subunit interface; other site 469383011824 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383011825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011826 dimer interface [polypeptide binding]; other site 469383011827 conserved gate region; other site 469383011828 ABC-ATPase subunit interface; other site 469383011829 NMT1/THI5 like; Region: NMT1; pfam09084 469383011830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 469383011831 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383011832 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383011833 Walker A/P-loop; other site 469383011834 ATP binding site [chemical binding]; other site 469383011835 Q-loop/lid; other site 469383011836 ABC transporter signature motif; other site 469383011837 Walker B; other site 469383011838 D-loop; other site 469383011839 H-loop/switch region; other site 469383011840 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383011841 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383011842 E3 interaction surface; other site 469383011843 lipoyl attachment site [posttranslational modification]; other site 469383011844 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383011845 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 469383011846 PYR/PP interface [polypeptide binding]; other site 469383011847 dimer interface [polypeptide binding]; other site 469383011848 TPP binding site [chemical binding]; other site 469383011849 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383011850 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 469383011851 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383011852 TPP-binding site [chemical binding]; other site 469383011853 tetramer interface [polypeptide binding]; other site 469383011854 heterodimer interface [polypeptide binding]; other site 469383011855 phosphorylation loop region [posttranslational modification] 469383011856 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383011857 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383011858 alpha subunit interface [polypeptide binding]; other site 469383011859 TPP binding site [chemical binding]; other site 469383011860 heterodimer interface [polypeptide binding]; other site 469383011861 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383011862 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 469383011863 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383011864 tetramer interface [polypeptide binding]; other site 469383011865 TPP-binding site [chemical binding]; other site 469383011866 heterodimer interface [polypeptide binding]; other site 469383011867 phosphorylation loop region [posttranslational modification] 469383011868 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383011869 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 469383011870 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383011871 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383011872 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383011873 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383011874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383011875 DNA-binding site [nucleotide binding]; DNA binding site 469383011876 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383011877 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 469383011878 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383011879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383011880 DNA-binding site [nucleotide binding]; DNA binding site 469383011881 FCD domain; Region: FCD; pfam07729 469383011882 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 469383011883 intersubunit interface [polypeptide binding]; other site 469383011884 active site 469383011885 Zn2+ binding site [ion binding]; other site 469383011886 FO synthase; Reviewed; Region: fbiC; PRK09234 469383011887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383011888 FeS/SAM binding site; other site 469383011889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383011890 FeS/SAM binding site; other site 469383011891 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 469383011892 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383011893 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 469383011894 NAD(P) binding site [chemical binding]; other site 469383011895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383011896 putative substrate translocation pore; other site 469383011897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383011898 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383011899 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383011900 NAD(P) binding site [chemical binding]; other site 469383011901 catalytic residues [active] 469383011902 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383011903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011904 dimer interface [polypeptide binding]; other site 469383011905 conserved gate region; other site 469383011906 putative PBP binding loops; other site 469383011907 ABC-ATPase subunit interface; other site 469383011908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383011909 dimer interface [polypeptide binding]; other site 469383011910 conserved gate region; other site 469383011911 putative PBP binding loops; other site 469383011912 ABC-ATPase subunit interface; other site 469383011913 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383011914 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383011915 Walker A/P-loop; other site 469383011916 ATP binding site [chemical binding]; other site 469383011917 Q-loop/lid; other site 469383011918 ABC transporter signature motif; other site 469383011919 Walker B; other site 469383011920 D-loop; other site 469383011921 H-loop/switch region; other site 469383011922 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 469383011923 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383011924 PYR/PP interface [polypeptide binding]; other site 469383011925 dimer interface [polypeptide binding]; other site 469383011926 TPP binding site [chemical binding]; other site 469383011927 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383011928 TPP-binding site [chemical binding]; other site 469383011929 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 469383011930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383011931 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 469383011932 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383011933 active site 469383011934 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383011935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 469383011936 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 469383011937 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383011938 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 469383011939 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 469383011940 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 469383011941 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 469383011942 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 469383011943 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 469383011944 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383011945 catalytic loop [active] 469383011946 iron binding site [ion binding]; other site 469383011947 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 469383011948 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 469383011949 putative hydrophobic ligand binding site [chemical binding]; other site 469383011950 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 469383011951 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 469383011952 metal ion-dependent adhesion site (MIDAS); other site 469383011953 MoxR-like ATPases [General function prediction only]; Region: COG0714 469383011954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383011955 Walker A motif; other site 469383011956 ATP binding site [chemical binding]; other site 469383011957 Walker B motif; other site 469383011958 arginine finger; other site 469383011959 Protein of unknown function (DUF917); Region: DUF917; pfam06032 469383011960 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383011961 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383011962 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383011963 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 469383011964 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 469383011965 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383011966 5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555 469383011967 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383011968 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 469383011969 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 469383011970 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 469383011971 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 469383011972 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 469383011973 catalytic loop [active] 469383011974 iron binding site [ion binding]; other site 469383011975 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 469383011976 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 469383011977 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383011978 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383011979 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383011980 Protein of unknown function (DUF917); Region: DUF917; pfam06032 469383011981 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383011982 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 469383011983 Predicted transcriptional regulator [Transcription]; Region: COG3655 469383011984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383011985 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383011986 TM-ABC transporter signature motif; other site 469383011987 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383011988 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383011989 Walker A/P-loop; other site 469383011990 ATP binding site [chemical binding]; other site 469383011991 Q-loop/lid; other site 469383011992 ABC transporter signature motif; other site 469383011993 Walker B; other site 469383011994 D-loop; other site 469383011995 H-loop/switch region; other site 469383011996 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383011997 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383011998 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383011999 ligand binding site [chemical binding]; other site 469383012000 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 469383012001 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 469383012002 XdhC Rossmann domain; Region: XdhC_C; pfam13478 469383012003 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 469383012004 active site 469383012005 catalytic residues [active] 469383012006 metal binding site [ion binding]; metal-binding site 469383012007 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 469383012008 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 469383012009 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 469383012010 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383012011 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 469383012012 NAD(P) binding site [chemical binding]; other site 469383012013 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383012014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383012015 active site 469383012016 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383012017 classical (c) SDRs; Region: SDR_c; cd05233 469383012018 NAD(P) binding site [chemical binding]; other site 469383012019 active site 469383012020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383012021 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 469383012022 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 469383012023 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 469383012024 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 469383012025 intersubunit interface [polypeptide binding]; other site 469383012026 active site 469383012027 Zn2+ binding site [ion binding]; other site 469383012028 Cupin domain; Region: Cupin_2; pfam07883 469383012029 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 469383012030 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 469383012031 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383012032 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383012033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383012034 DNA-binding site [nucleotide binding]; DNA binding site 469383012035 FCD domain; Region: FCD; pfam07729 469383012036 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 469383012037 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383012038 active site 469383012039 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 469383012040 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383012041 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 469383012042 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383012043 Walker A/P-loop; other site 469383012044 ATP binding site [chemical binding]; other site 469383012045 Q-loop/lid; other site 469383012046 ABC transporter signature motif; other site 469383012047 Walker B; other site 469383012048 D-loop; other site 469383012049 H-loop/switch region; other site 469383012050 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383012051 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383012052 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 469383012053 TM-ABC transporter signature motif; other site 469383012054 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 469383012055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383012056 TM-ABC transporter signature motif; other site 469383012057 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 469383012058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383012059 catalytic residue [active] 469383012060 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 469383012061 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 469383012062 metal binding site [ion binding]; metal-binding site 469383012063 dimer interface [polypeptide binding]; other site 469383012064 FO synthase; Reviewed; Region: fbiC; PRK09234 469383012065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383012066 FeS/SAM binding site; other site 469383012067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383012068 FeS/SAM binding site; other site 469383012069 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 469383012070 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383012071 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 469383012072 dimer interface [polypeptide binding]; other site 469383012073 phosphate binding site [ion binding]; other site 469383012074 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 469383012075 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 469383012076 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 469383012077 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383012078 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 469383012079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383012080 NAD(P) binding site [chemical binding]; other site 469383012081 active site 469383012082 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 469383012083 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 469383012084 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 469383012085 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 469383012086 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 469383012087 dimer interface [polypeptide binding]; other site 469383012088 active site 469383012089 acyl carrier protein; Provisional; Region: acpP; PRK00982 469383012090 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 469383012091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383012092 NAD(P) binding site [chemical binding]; other site 469383012093 active site 469383012094 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 469383012095 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 469383012096 dimer interface [polypeptide binding]; other site 469383012097 active site 469383012098 CoA binding pocket [chemical binding]; other site 469383012099 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 469383012100 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 469383012101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383012102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383012103 active site 469383012104 phosphorylation site [posttranslational modification] 469383012105 intermolecular recognition site; other site 469383012106 dimerization interface [polypeptide binding]; other site 469383012107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383012108 DNA binding residues [nucleotide binding] 469383012109 dimerization interface [polypeptide binding]; other site 469383012110 GAF domain; Region: GAF_3; pfam13492 469383012111 FO synthase; Reviewed; Region: fbiC; PRK09234 469383012112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383012113 FeS/SAM binding site; other site 469383012114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383012115 FeS/SAM binding site; other site 469383012116 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383012117 putative oxidoreductase; Provisional; Region: PRK11579 469383012118 NMT1/THI5 like; Region: NMT1; pfam09084 469383012119 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 469383012120 classical (c) SDRs; Region: SDR_c; cd05233 469383012121 NAD(P) binding site [chemical binding]; other site 469383012122 active site 469383012123 manganese transport protein MntH; Reviewed; Region: PRK00701 469383012124 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 469383012125 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 469383012126 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 469383012127 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 469383012128 FeoA domain; Region: FeoA; pfam04023 469383012129 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 469383012130 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 469383012131 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 469383012132 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383012133 MarR family; Region: MarR_2; pfam12802 469383012134 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 469383012135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383012136 putative substrate translocation pore; other site 469383012137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383012138 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 469383012139 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 469383012140 oligomer interface [polypeptide binding]; other site 469383012141 metal binding site [ion binding]; metal-binding site 469383012142 metal binding site [ion binding]; metal-binding site 469383012143 putative Cl binding site [ion binding]; other site 469383012144 aspartate ring; other site 469383012145 hydrophobic gate; other site 469383012146 periplasmic entrance; other site 469383012147 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 469383012148 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383012149 DNA binding residues [nucleotide binding] 469383012150 drug binding residues [chemical binding]; other site 469383012151 dimer interface [polypeptide binding]; other site 469383012152 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 469383012153 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 469383012154 putative dimer interface [polypeptide binding]; other site 469383012155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383012156 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 469383012157 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383012158 NAD(P) binding site [chemical binding]; other site 469383012159 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 469383012160 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383012161 dimerization interface [polypeptide binding]; other site 469383012162 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 469383012163 cyclase homology domain; Region: CHD; cd07302 469383012164 nucleotidyl binding site; other site 469383012165 metal binding site [ion binding]; metal-binding site 469383012166 dimer interface [polypeptide binding]; other site 469383012167 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383012168 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 469383012169 Fatty acid desaturase; Region: FA_desaturase; pfam00487 469383012170 Di-iron ligands [ion binding]; other site 469383012171 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 469383012172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383012173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383012174 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 469383012175 Walker A/P-loop; other site 469383012176 ATP binding site [chemical binding]; other site 469383012177 Q-loop/lid; other site 469383012178 ABC transporter signature motif; other site 469383012179 Walker B; other site 469383012180 D-loop; other site 469383012181 H-loop/switch region; other site 469383012182 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 469383012183 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383012184 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383012185 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 469383012186 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383012187 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 469383012188 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 469383012189 B12 binding site [chemical binding]; other site 469383012190 cobalt ligand [ion binding]; other site 469383012191 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383012192 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 469383012193 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 469383012194 putative active site [active] 469383012195 catalytic site [active] 469383012196 putative metal binding site [ion binding]; other site 469383012197 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383012198 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 469383012199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 469383012200 FeS/SAM binding site; other site 469383012201 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 469383012202 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383012203 homotrimer interaction site [polypeptide binding]; other site 469383012204 putative active site [active] 469383012205 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 469383012206 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 469383012207 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 469383012208 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 469383012209 GTP binding site; other site 469383012210 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 469383012211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383012212 S-adenosylmethionine binding site [chemical binding]; other site 469383012213 Protein of unknown function (DUF419); Region: DUF419; pfam04237 469383012214 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 469383012215 active site 469383012216 substrate-binding site [chemical binding]; other site 469383012217 metal-binding site [ion binding] 469383012218 GTP binding site [chemical binding]; other site 469383012219 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 469383012220 putative active site [active] 469383012221 putative catalytic site [active] 469383012222 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 469383012223 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 469383012224 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 469383012225 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 469383012226 CoA binding domain; Region: CoA_binding; smart00881 469383012227 CoA-ligase; Region: Ligase_CoA; pfam00549 469383012228 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 469383012229 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 469383012230 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 469383012231 putative active site; other site 469383012232 catalytic triad [active] 469383012233 putative dimer interface [polypeptide binding]; other site 469383012234 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 469383012235 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 469383012236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383012237 dimerization interface [polypeptide binding]; other site 469383012238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 469383012239 dimer interface [polypeptide binding]; other site 469383012240 putative CheW interface [polypeptide binding]; other site 469383012241 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383012242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383012243 active site 469383012244 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 469383012245 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383012246 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383012247 acyl-activating enzyme (AAE) consensus motif; other site 469383012248 AMP binding site [chemical binding]; other site 469383012249 active site 469383012250 CoA binding site [chemical binding]; other site 469383012251 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 469383012252 4Fe-4S binding domain; Region: Fer4_6; pfam12837 469383012253 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 469383012254 Peptidase C26; Region: Peptidase_C26; pfam07722 469383012255 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 469383012256 catalytic triad [active] 469383012257 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383012258 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383012259 DNA binding residues [nucleotide binding] 469383012260 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 469383012261 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383012262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383012263 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383012264 DNA binding residues [nucleotide binding] 469383012265 threonine dehydratase; Provisional; Region: PRK08198 469383012266 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 469383012267 tetramer interface [polypeptide binding]; other site 469383012268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383012269 catalytic residue [active] 469383012270 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 469383012271 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383012272 homotrimer interaction site [polypeptide binding]; other site 469383012273 putative active site [active] 469383012274 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 469383012275 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 469383012276 catalytic residues [active] 469383012277 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383012278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383012279 S-adenosylmethionine binding site [chemical binding]; other site 469383012280 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 469383012281 dimer interface [polypeptide binding]; other site 469383012282 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 469383012283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383012284 Coenzyme A binding pocket [chemical binding]; other site 469383012285 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 469383012286 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 469383012287 tetrameric interface [polypeptide binding]; other site 469383012288 NAD binding site [chemical binding]; other site 469383012289 catalytic residues [active] 469383012290 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 469383012291 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 469383012292 tetrameric interface [polypeptide binding]; other site 469383012293 NAD binding site [chemical binding]; other site 469383012294 catalytic residues [active] 469383012295 substrate binding site [chemical binding]; other site 469383012296 hypothetical protein; Provisional; Region: PRK06541 469383012297 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383012298 inhibitor-cofactor binding pocket; inhibition site 469383012299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383012300 catalytic residue [active] 469383012301 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383012302 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383012303 ferredoxin-NADP+ reductase; Region: PLN02852 469383012304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383012305 MMPL family; Region: MMPL; pfam03176 469383012306 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 469383012307 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 469383012308 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 469383012309 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 469383012310 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383012311 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 469383012312 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 469383012313 cytochrome c-550; Provisional; Region: psbV; cl17239 469383012314 Cytochrome c; Region: Cytochrom_C; cl11414 469383012315 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 469383012316 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 469383012317 active site 469383012318 PHP Thumb interface [polypeptide binding]; other site 469383012319 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 469383012320 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 469383012321 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 469383012322 generic binding surface II; other site 469383012323 generic binding surface I; other site 469383012324 DNA Polymerase Y-family; Region: PolY_like; cd03468 469383012325 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 469383012326 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 469383012327 active site 469383012328 putative substrate binding pocket [chemical binding]; other site 469383012329 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383012330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012331 putative PBP binding loops; other site 469383012332 dimer interface [polypeptide binding]; other site 469383012333 ABC-ATPase subunit interface; other site 469383012334 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383012335 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383012336 Walker A/P-loop; other site 469383012337 ATP binding site [chemical binding]; other site 469383012338 Q-loop/lid; other site 469383012339 ABC transporter signature motif; other site 469383012340 Walker B; other site 469383012341 D-loop; other site 469383012342 H-loop/switch region; other site 469383012343 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 469383012344 NMT1/THI5 like; Region: NMT1; pfam09084 469383012345 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 469383012346 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 469383012347 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383012348 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 469383012349 active site 469383012350 oxyanion hole [active] 469383012351 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 469383012352 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 469383012353 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 469383012354 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383012355 Ligand Binding Site [chemical binding]; other site 469383012356 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383012357 Ligand Binding Site [chemical binding]; other site 469383012358 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 469383012359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383012360 ATP binding site [chemical binding]; other site 469383012361 Mg2+ binding site [ion binding]; other site 469383012362 G-X-G motif; other site 469383012363 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 469383012364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 469383012365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383012366 Walker A/P-loop; other site 469383012367 ATP binding site [chemical binding]; other site 469383012368 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383012369 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383012370 DNA binding residues [nucleotide binding] 469383012371 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 469383012372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383012373 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383012374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383012375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383012376 Cupin domain; Region: Cupin_2; pfam07883 469383012377 agmatinase; Region: agmatinase; TIGR01230 469383012378 Agmatinase-like family; Region: Agmatinase-like; cd09990 469383012379 active site 469383012380 oligomer interface [polypeptide binding]; other site 469383012381 Mn binding site [ion binding]; other site 469383012382 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383012383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012384 dimer interface [polypeptide binding]; other site 469383012385 conserved gate region; other site 469383012386 ABC-ATPase subunit interface; other site 469383012387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012388 dimer interface [polypeptide binding]; other site 469383012389 conserved gate region; other site 469383012390 putative PBP binding loops; other site 469383012391 ABC-ATPase subunit interface; other site 469383012392 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 469383012393 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383012394 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383012395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383012396 Walker A/P-loop; other site 469383012397 ATP binding site [chemical binding]; other site 469383012398 Q-loop/lid; other site 469383012399 ABC transporter signature motif; other site 469383012400 Walker B; other site 469383012401 D-loop; other site 469383012402 H-loop/switch region; other site 469383012403 TOBE domain; Region: TOBE_2; pfam08402 469383012404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383012405 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 469383012406 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383012407 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 469383012408 active site 469383012409 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383012410 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 469383012411 beta-galactosidase; Region: BGL; TIGR03356 469383012412 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 469383012413 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383012414 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383012415 TM-ABC transporter signature motif; other site 469383012416 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383012417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383012418 Walker A/P-loop; other site 469383012419 ATP binding site [chemical binding]; other site 469383012420 Q-loop/lid; other site 469383012421 ABC transporter signature motif; other site 469383012422 Walker B; other site 469383012423 D-loop; other site 469383012424 H-loop/switch region; other site 469383012425 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 469383012426 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 469383012427 putative ligand binding site [chemical binding]; other site 469383012428 MarR family; Region: MarR_2; cl17246 469383012429 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383012430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 469383012431 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 469383012432 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 469383012433 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 469383012434 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 469383012435 putative sugar binding sites [chemical binding]; other site 469383012436 Q-X-W motif; other site 469383012437 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383012438 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 469383012439 intersubunit interface [polypeptide binding]; other site 469383012440 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 469383012441 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 469383012442 ABC-ATPase subunit interface; other site 469383012443 dimer interface [polypeptide binding]; other site 469383012444 putative PBP binding regions; other site 469383012445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 469383012446 ABC-ATPase subunit interface; other site 469383012447 dimer interface [polypeptide binding]; other site 469383012448 putative PBP binding regions; other site 469383012449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 469383012450 metal binding site 2 [ion binding]; metal-binding site 469383012451 putative DNA binding helix; other site 469383012452 metal binding site 1 [ion binding]; metal-binding site 469383012453 dimer interface [polypeptide binding]; other site 469383012454 structural Zn2+ binding site [ion binding]; other site 469383012455 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 469383012456 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 469383012457 PDGLE domain; Region: PDGLE; pfam13190 469383012458 Cobalt transport protein; Region: CbiQ; cl00463 469383012459 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 469383012460 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 469383012461 Walker A/P-loop; other site 469383012462 ATP binding site [chemical binding]; other site 469383012463 Q-loop/lid; other site 469383012464 ABC transporter signature motif; other site 469383012465 Walker B; other site 469383012466 D-loop; other site 469383012467 H-loop/switch region; other site 469383012468 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383012469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383012470 DNA-binding site [nucleotide binding]; DNA binding site 469383012471 FCD domain; Region: FCD; pfam07729 469383012472 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 469383012473 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383012474 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 469383012475 putative active site [active] 469383012476 putative catalytic site [active] 469383012477 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 469383012478 active site 2 [active] 469383012479 active site 1 [active] 469383012480 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 469383012481 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 469383012482 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 469383012483 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 469383012484 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 469383012485 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 469383012486 active site 469383012487 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 469383012488 flagellin; Provisional; Region: PRK12804 469383012489 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 469383012490 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 469383012491 flagellin; Provisional; Region: PRK12804 469383012492 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 469383012493 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 469383012494 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383012495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383012496 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 469383012497 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 469383012498 Ligand binding site; other site 469383012499 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469383012500 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383012501 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383012502 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383012503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383012504 DNA-binding site [nucleotide binding]; DNA binding site 469383012505 FCD domain; Region: FCD; pfam07729 469383012506 AAA domain; Region: AAA_14; pfam13173 469383012507 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 469383012508 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383012509 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383012510 E3 interaction surface; other site 469383012511 lipoyl attachment site [posttranslational modification]; other site 469383012512 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383012513 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383012514 alpha subunit interface [polypeptide binding]; other site 469383012515 TPP binding site [chemical binding]; other site 469383012516 heterodimer interface [polypeptide binding]; other site 469383012517 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383012518 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 469383012519 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383012520 tetramer interface [polypeptide binding]; other site 469383012521 TPP-binding site [chemical binding]; other site 469383012522 heterodimer interface [polypeptide binding]; other site 469383012523 phosphorylation loop region [posttranslational modification] 469383012524 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 469383012525 ligand binding site [chemical binding]; other site 469383012526 NAD binding site [chemical binding]; other site 469383012527 catalytic site [active] 469383012528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383012529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383012530 NAD(P) binding site [chemical binding]; other site 469383012531 active site 469383012532 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383012533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383012534 DNA-binding site [nucleotide binding]; DNA binding site 469383012535 FCD domain; Region: FCD; pfam07729 469383012536 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383012537 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 469383012538 Walker A/P-loop; other site 469383012539 ATP binding site [chemical binding]; other site 469383012540 Q-loop/lid; other site 469383012541 ABC transporter signature motif; other site 469383012542 Walker B; other site 469383012543 D-loop; other site 469383012544 H-loop/switch region; other site 469383012545 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383012546 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383012547 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383012548 ligand binding site [chemical binding]; other site 469383012549 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383012550 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383012551 TM-ABC transporter signature motif; other site 469383012552 classical (c) SDRs; Region: SDR_c; cd05233 469383012553 NAD(P) binding site [chemical binding]; other site 469383012554 active site 469383012555 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 469383012556 catalytic residues [active] 469383012557 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383012558 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469383012559 active site 469383012560 metal binding site [ion binding]; metal-binding site 469383012561 Septum formation; Region: Septum_form; pfam13845 469383012562 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 469383012563 Domain of unknown function DUF20; Region: UPF0118; pfam01594 469383012564 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 469383012565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 469383012566 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383012567 Ferritin-like domain; Region: Ferritin_2; pfam13668 469383012568 Ferritin-like domain; Region: Ferritin_2; pfam13668 469383012569 RibD C-terminal domain; Region: RibD_C; cl17279 469383012570 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383012571 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383012572 NAD(P) binding site [chemical binding]; other site 469383012573 catalytic residues [active] 469383012574 Queuine tRNA-ribosyltransferases, contain PUA domain [Translation, ribosomal structure and biogenesis]; Region: COG1549 469383012575 Predicted amidohydrolase [General function prediction only]; Region: COG0388 469383012576 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 469383012577 active site 469383012578 catalytic triad [active] 469383012579 dimer interface [polypeptide binding]; other site 469383012580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383012581 active site 469383012582 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 469383012583 catalytic triad [active] 469383012584 Isochorismatase family; Region: Isochorismatase; pfam00857 469383012585 conserved cis-peptide bond; other site 469383012586 phenylhydantoinase; Validated; Region: PRK08323 469383012587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383012588 active site 469383012589 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 469383012590 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 469383012591 active site 469383012592 purine riboside binding site [chemical binding]; other site 469383012593 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 469383012594 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 469383012595 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383012596 ligand binding site [chemical binding]; other site 469383012597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383012598 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383012599 TM-ABC transporter signature motif; other site 469383012600 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 469383012601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383012602 Walker A/P-loop; other site 469383012603 ATP binding site [chemical binding]; other site 469383012604 Q-loop/lid; other site 469383012605 ABC transporter signature motif; other site 469383012606 Walker B; other site 469383012607 D-loop; other site 469383012608 H-loop/switch region; other site 469383012609 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 469383012610 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 469383012611 homotrimer interaction site [polypeptide binding]; other site 469383012612 putative active site [active] 469383012613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383012614 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 469383012615 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 469383012616 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 469383012617 putative active site [active] 469383012618 putative substrate binding site [chemical binding]; other site 469383012619 putative cosubstrate binding site; other site 469383012620 catalytic site [active] 469383012621 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 469383012622 FAD binding site [chemical binding]; other site 469383012623 Adenosylhomocysteinase; Provisional; Region: PTZ00075 469383012624 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 469383012625 homotetramer interface [polypeptide binding]; other site 469383012626 ligand binding site [chemical binding]; other site 469383012627 catalytic site [active] 469383012628 NAD binding site [chemical binding]; other site 469383012629 S-adenosylmethionine synthetase; Validated; Region: PRK05250 469383012630 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 469383012631 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 469383012632 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 469383012633 GAF domain; Region: GAF; cl17456 469383012634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383012635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383012636 DNA binding residues [nucleotide binding] 469383012637 dimerization interface [polypeptide binding]; other site 469383012638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383012639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383012640 DNA binding residues [nucleotide binding] 469383012641 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 469383012642 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383012643 molybdopterin cofactor binding site; other site 469383012644 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 469383012645 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 469383012646 putative molybdopterin cofactor binding site; other site 469383012647 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 469383012648 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 469383012649 FAD binding pocket [chemical binding]; other site 469383012650 FAD binding motif [chemical binding]; other site 469383012651 phosphate binding motif [ion binding]; other site 469383012652 beta-alpha-beta structure motif; other site 469383012653 NAD binding pocket [chemical binding]; other site 469383012654 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383012655 catalytic loop [active] 469383012656 iron binding site [ion binding]; other site 469383012657 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383012658 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 469383012659 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 469383012660 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 469383012661 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 469383012662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383012663 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 469383012664 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383012665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383012666 DNA-binding site [nucleotide binding]; DNA binding site 469383012667 FCD domain; Region: FCD; pfam07729 469383012668 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383012669 Amidase; Region: Amidase; cl11426 469383012670 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 469383012671 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383012672 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383012673 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383012674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012675 dimer interface [polypeptide binding]; other site 469383012676 conserved gate region; other site 469383012677 ABC-ATPase subunit interface; other site 469383012678 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383012679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012680 dimer interface [polypeptide binding]; other site 469383012681 conserved gate region; other site 469383012682 putative PBP binding loops; other site 469383012683 ABC-ATPase subunit interface; other site 469383012684 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383012685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383012686 Walker A/P-loop; other site 469383012687 ATP binding site [chemical binding]; other site 469383012688 Q-loop/lid; other site 469383012689 ABC transporter signature motif; other site 469383012690 Walker B; other site 469383012691 D-loop; other site 469383012692 H-loop/switch region; other site 469383012693 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383012694 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 469383012695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383012696 Walker A/P-loop; other site 469383012697 ATP binding site [chemical binding]; other site 469383012698 Q-loop/lid; other site 469383012699 ABC transporter signature motif; other site 469383012700 Walker B; other site 469383012701 D-loop; other site 469383012702 H-loop/switch region; other site 469383012703 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383012704 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 469383012705 aspartate racemase; Region: asp_race; TIGR00035 469383012706 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383012707 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383012708 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 469383012709 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383012710 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383012711 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383012712 TM-ABC transporter signature motif; other site 469383012713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383012714 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383012715 TM-ABC transporter signature motif; other site 469383012716 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383012717 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383012718 Walker A/P-loop; other site 469383012719 ATP binding site [chemical binding]; other site 469383012720 Q-loop/lid; other site 469383012721 ABC transporter signature motif; other site 469383012722 Walker B; other site 469383012723 D-loop; other site 469383012724 H-loop/switch region; other site 469383012725 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383012726 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383012727 Walker A/P-loop; other site 469383012728 ATP binding site [chemical binding]; other site 469383012729 Q-loop/lid; other site 469383012730 ABC transporter signature motif; other site 469383012731 Walker B; other site 469383012732 D-loop; other site 469383012733 H-loop/switch region; other site 469383012734 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 469383012735 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 469383012736 ligand binding site [chemical binding]; other site 469383012737 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 469383012738 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383012739 substrate binding site [chemical binding]; other site 469383012740 ATP binding site [chemical binding]; other site 469383012741 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 469383012742 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 469383012743 putative methyltransferase; Provisional; Region: PRK14967 469383012744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383012745 S-adenosylmethionine binding site [chemical binding]; other site 469383012746 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 469383012747 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383012748 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 469383012749 NAD binding site [chemical binding]; other site 469383012750 Phe binding site; other site 469383012751 PAS fold; Region: PAS_4; pfam08448 469383012752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383012753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383012754 dimer interface [polypeptide binding]; other site 469383012755 phosphorylation site [posttranslational modification] 469383012756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383012757 ATP binding site [chemical binding]; other site 469383012758 Mg2+ binding site [ion binding]; other site 469383012759 G-X-G motif; other site 469383012760 Response regulator receiver domain; Region: Response_reg; pfam00072 469383012761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383012762 active site 469383012763 phosphorylation site [posttranslational modification] 469383012764 intermolecular recognition site; other site 469383012765 dimerization interface [polypeptide binding]; other site 469383012766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383012767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383012768 active site 469383012769 phosphorylation site [posttranslational modification] 469383012770 intermolecular recognition site; other site 469383012771 dimerization interface [polypeptide binding]; other site 469383012772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383012773 DNA binding residues [nucleotide binding] 469383012774 dimerization interface [polypeptide binding]; other site 469383012775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383012776 classical (c) SDRs; Region: SDR_c; cd05233 469383012777 NAD(P) binding site [chemical binding]; other site 469383012778 active site 469383012779 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 469383012780 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 469383012781 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 469383012782 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 469383012783 Uncharacterized conserved protein [Function unknown]; Region: COG0327 469383012784 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 469383012785 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 469383012786 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 469383012787 classical (c) SDRs; Region: SDR_c; cd05233 469383012788 NAD(P) binding site [chemical binding]; other site 469383012789 active site 469383012790 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 469383012791 substrate binding site [chemical binding]; other site 469383012792 THF binding site; other site 469383012793 zinc-binding site [ion binding]; other site 469383012794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383012795 S-adenosylmethionine binding site [chemical binding]; other site 469383012796 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383012797 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 469383012798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 469383012799 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 469383012800 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383012801 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383012802 E3 interaction surface; other site 469383012803 lipoyl attachment site [posttranslational modification]; other site 469383012804 e3 binding domain; Region: E3_binding; pfam02817 469383012805 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383012806 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383012807 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383012808 alpha subunit interface [polypeptide binding]; other site 469383012809 TPP binding site [chemical binding]; other site 469383012810 heterodimer interface [polypeptide binding]; other site 469383012811 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383012812 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 469383012813 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383012814 tetramer interface [polypeptide binding]; other site 469383012815 TPP-binding site [chemical binding]; other site 469383012816 heterodimer interface [polypeptide binding]; other site 469383012817 phosphorylation loop region [posttranslational modification] 469383012818 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383012819 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 469383012820 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 469383012821 active site 469383012822 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 469383012823 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383012824 E3 interaction surface; other site 469383012825 lipoyl attachment site [posttranslational modification]; other site 469383012826 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383012827 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383012828 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383012829 alpha subunit interface [polypeptide binding]; other site 469383012830 TPP binding site [chemical binding]; other site 469383012831 heterodimer interface [polypeptide binding]; other site 469383012832 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383012833 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383012834 tetramer interface [polypeptide binding]; other site 469383012835 TPP-binding site [chemical binding]; other site 469383012836 heterodimer interface [polypeptide binding]; other site 469383012837 phosphorylation loop region [posttranslational modification] 469383012838 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 469383012839 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383012840 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 469383012841 NAD(P) binding pocket [chemical binding]; other site 469383012842 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383012843 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 469383012844 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 469383012845 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 469383012846 classical (c) SDRs; Region: SDR_c; cd05233 469383012847 NAD(P) binding site [chemical binding]; other site 469383012848 active site 469383012849 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 469383012850 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 469383012851 catalytic triad [active] 469383012852 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383012853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383012854 DNA-binding site [nucleotide binding]; DNA binding site 469383012855 FCD domain; Region: FCD; pfam07729 469383012856 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383012857 NAD(P) binding site [chemical binding]; other site 469383012858 catalytic residues [active] 469383012859 ferredoxin-NADP+ reductase; Region: PLN02852 469383012860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383012861 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383012862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383012863 DNA-binding site [nucleotide binding]; DNA binding site 469383012864 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383012865 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 469383012866 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 469383012867 active site 469383012868 NAD binding site [chemical binding]; other site 469383012869 metal binding site [ion binding]; metal-binding site 469383012870 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383012871 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383012872 NAD(P) binding site [chemical binding]; other site 469383012873 catalytic residues [active] 469383012874 Peptidase C26; Region: Peptidase_C26; pfam07722 469383012875 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 469383012876 catalytic triad [active] 469383012877 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 469383012878 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 469383012879 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383012880 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383012881 DNA binding site [nucleotide binding] 469383012882 domain linker motif; other site 469383012883 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383012884 ligand binding site [chemical binding]; other site 469383012885 dimerization interface [polypeptide binding]; other site 469383012886 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 469383012887 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 469383012888 Cytochrome P450; Region: p450; cl12078 469383012889 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383012890 NHL repeat; Region: NHL; pfam01436 469383012891 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 469383012892 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 469383012893 NAD binding site [chemical binding]; other site 469383012894 catalytic Zn binding site [ion binding]; other site 469383012895 structural Zn binding site [ion binding]; other site 469383012896 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 469383012897 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383012898 Walker A/P-loop; other site 469383012899 ATP binding site [chemical binding]; other site 469383012900 Q-loop/lid; other site 469383012901 ABC transporter signature motif; other site 469383012902 Walker B; other site 469383012903 D-loop; other site 469383012904 H-loop/switch region; other site 469383012905 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383012906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012907 putative PBP binding loops; other site 469383012908 dimer interface [polypeptide binding]; other site 469383012909 ABC-ATPase subunit interface; other site 469383012910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012911 dimer interface [polypeptide binding]; other site 469383012912 conserved gate region; other site 469383012913 putative PBP binding loops; other site 469383012914 ABC-ATPase subunit interface; other site 469383012915 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383012916 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383012917 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 469383012918 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 469383012919 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383012920 Cytochrome P450; Region: p450; cl12078 469383012921 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383012922 Cytochrome P450; Region: p450; cl12078 469383012923 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383012924 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383012925 hypothetical protein; Provisional; Region: PRK06834 469383012926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383012927 hypothetical protein; Provisional; Region: PRK07236 469383012928 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 469383012929 putative active site [active] 469383012930 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383012931 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 469383012932 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383012933 AsnC family; Region: AsnC_trans_reg; pfam01037 469383012934 hypothetical protein; Provisional; Region: PRK08204 469383012935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383012936 active site 469383012937 NMT1/THI5 like; Region: NMT1; pfam09084 469383012938 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383012939 Transcriptional regulator PadR-like family; Region: PadR; cl17335 469383012940 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383012941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383012942 active site 469383012943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 469383012944 REDY-like protein HapK; Region: HapK; pfam11639 469383012945 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383012946 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383012947 active site 469383012948 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 469383012949 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383012950 acyl-activating enzyme (AAE) consensus motif; other site 469383012951 AMP binding site [chemical binding]; other site 469383012952 active site 469383012953 CoA binding site [chemical binding]; other site 469383012954 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 469383012955 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383012956 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383012957 DNA binding site [nucleotide binding] 469383012958 domain linker motif; other site 469383012959 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383012960 dimerization interface [polypeptide binding]; other site 469383012961 ligand binding site [chemical binding]; other site 469383012962 Dehydratase family; Region: ILVD_EDD; cl00340 469383012963 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 469383012964 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383012965 classical (c) SDRs; Region: SDR_c; cd05233 469383012966 NAD(P) binding site [chemical binding]; other site 469383012967 active site 469383012968 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383012969 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383012970 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 469383012971 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 469383012972 active site 469383012973 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383012974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012975 dimer interface [polypeptide binding]; other site 469383012976 conserved gate region; other site 469383012977 putative PBP binding loops; other site 469383012978 ABC-ATPase subunit interface; other site 469383012979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383012980 dimer interface [polypeptide binding]; other site 469383012981 conserved gate region; other site 469383012982 putative PBP binding loops; other site 469383012983 ABC-ATPase subunit interface; other site 469383012984 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383012985 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383012986 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383012987 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383012988 Walker A/P-loop; other site 469383012989 ATP binding site [chemical binding]; other site 469383012990 Q-loop/lid; other site 469383012991 ABC transporter signature motif; other site 469383012992 Walker B; other site 469383012993 D-loop; other site 469383012994 H-loop/switch region; other site 469383012995 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 469383012996 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 469383012997 active site 469383012998 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383012999 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383013000 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 469383013001 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383013002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383013003 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 469383013004 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 469383013005 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383013006 active site 469383013007 substrate binding site [chemical binding]; other site 469383013008 Phosphotransferase enzyme family; Region: APH; pfam01636 469383013009 ATP binding site [chemical binding]; other site 469383013010 Helix-turn-helix domain; Region: HTH_31; pfam13560 469383013011 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383013012 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 469383013013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383013014 Walker A/P-loop; other site 469383013015 ATP binding site [chemical binding]; other site 469383013016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383013017 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383013018 Walker A/P-loop; other site 469383013019 ATP binding site [chemical binding]; other site 469383013020 Q-loop/lid; other site 469383013021 ABC transporter signature motif; other site 469383013022 Walker B; other site 469383013023 D-loop; other site 469383013024 H-loop/switch region; other site 469383013025 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383013026 FtsX-like permease family; Region: FtsX; pfam02687 469383013027 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 469383013028 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 469383013029 LexA repressor; Validated; Region: PRK00215 469383013030 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 469383013031 Catalytic site [active] 469383013032 Phosphotransferase enzyme family; Region: APH; pfam01636 469383013033 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383013034 active site 469383013035 substrate binding site [chemical binding]; other site 469383013036 ATP binding site [chemical binding]; other site 469383013037 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 469383013038 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 469383013039 active site residue [active] 469383013040 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 469383013041 active site residue [active] 469383013042 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 469383013043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383013044 Zn2+ binding site [ion binding]; other site 469383013045 Mg2+ binding site [ion binding]; other site 469383013046 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 469383013047 CcmE; Region: CcmE; cl00994 469383013048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383013049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383013050 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 469383013051 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 469383013052 acyl-activating enzyme (AAE) consensus motif; other site 469383013053 putative AMP binding site [chemical binding]; other site 469383013054 putative active site [active] 469383013055 putative CoA binding site [chemical binding]; other site 469383013056 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 469383013057 anti sigma factor interaction site; other site 469383013058 regulatory phosphorylation site [posttranslational modification]; other site 469383013059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 469383013060 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 469383013061 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 469383013062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383013063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383013064 DNA binding residues [nucleotide binding] 469383013065 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383013066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383013067 S-adenosylmethionine binding site [chemical binding]; other site 469383013068 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383013069 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 469383013070 Ferritin-like domain; Region: Ferritin; pfam00210 469383013071 dinuclear metal binding motif [ion binding]; other site 469383013072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383013073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383013074 metal binding site [ion binding]; metal-binding site 469383013075 active site 469383013076 I-site; other site 469383013077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383013078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383013079 DNA binding site [nucleotide binding] 469383013080 PBP superfamily domain; Region: PBP_like_2; cl17296 469383013081 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 469383013082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383013083 dimer interface [polypeptide binding]; other site 469383013084 conserved gate region; other site 469383013085 putative PBP binding loops; other site 469383013086 ABC-ATPase subunit interface; other site 469383013087 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 469383013088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383013089 dimer interface [polypeptide binding]; other site 469383013090 conserved gate region; other site 469383013091 putative PBP binding loops; other site 469383013092 ABC-ATPase subunit interface; other site 469383013093 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 469383013094 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 469383013095 Walker A/P-loop; other site 469383013096 ATP binding site [chemical binding]; other site 469383013097 Q-loop/lid; other site 469383013098 ABC transporter signature motif; other site 469383013099 Walker B; other site 469383013100 D-loop; other site 469383013101 H-loop/switch region; other site 469383013102 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 469383013103 PhoU domain; Region: PhoU; pfam01895 469383013104 PhoU domain; Region: PhoU; pfam01895 469383013105 Calx-beta domain; Region: Calx-beta; cl02522 469383013106 Calx-beta domain; Region: Calx-beta; cl02522 469383013107 Putative Ig domain; Region: He_PIG; pfam05345 469383013108 Putative Ig domain; Region: He_PIG; pfam05345 469383013109 Family description; Region: VCBS; pfam13517 469383013110 Family description; Region: VCBS; pfam13517 469383013111 Family description; Region: VCBS; pfam13517 469383013112 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383013113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383013114 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 469383013115 Walker A motif; other site 469383013116 ATP binding site [chemical binding]; other site 469383013117 Walker B motif; other site 469383013118 arginine finger; other site 469383013119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383013120 Walker A motif; other site 469383013121 ATP binding site [chemical binding]; other site 469383013122 Walker B motif; other site 469383013123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 469383013124 Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960 469383013125 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 469383013126 PKD domain; Region: PKD; pfam00801 469383013127 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 469383013128 Ligand binding site; other site 469383013129 Ligand binding site; other site 469383013130 Ligand binding site; other site 469383013131 Putative Catalytic site; other site 469383013132 DXD motif; other site 469383013133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383013134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383013135 dimerization interface [polypeptide binding]; other site 469383013136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383013137 dimer interface [polypeptide binding]; other site 469383013138 phosphorylation site [posttranslational modification] 469383013139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383013140 ATP binding site [chemical binding]; other site 469383013141 Mg2+ binding site [ion binding]; other site 469383013142 G-X-G motif; other site 469383013143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383013144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383013145 active site 469383013146 phosphorylation site [posttranslational modification] 469383013147 intermolecular recognition site; other site 469383013148 dimerization interface [polypeptide binding]; other site 469383013149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383013150 DNA binding site [nucleotide binding] 469383013151 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 469383013152 transport protein TonB; Provisional; Region: PRK10819 469383013153 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 469383013154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383013155 putative substrate translocation pore; other site 469383013156 translation initiation factor Sui1; Validated; Region: PRK06824 469383013157 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 469383013158 putative rRNA binding site [nucleotide binding]; other site 469383013159 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 469383013160 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469383013161 catalytic residues [active] 469383013162 Cytochrome C biogenesis protein; Region: CcmH; cl01179 469383013163 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 469383013164 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 469383013165 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 469383013166 active site 469383013167 HIGH motif; other site 469383013168 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383013169 KMSK motif region; other site 469383013170 tRNA binding surface [nucleotide binding]; other site 469383013171 DALR anticodon binding domain; Region: DALR_1; smart00836 469383013172 anticodon binding site; other site 469383013173 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 469383013174 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 469383013175 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 469383013176 Ligand Binding Site [chemical binding]; other site 469383013177 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469383013178 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 469383013179 active site 469383013180 metal binding site [ion binding]; metal-binding site 469383013181 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 469383013182 Catalytic domain of Protein Kinases; Region: PKc; cd00180 469383013183 active site 469383013184 ATP binding site [chemical binding]; other site 469383013185 substrate binding site [chemical binding]; other site 469383013186 activation loop (A-loop); other site 469383013187 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 469383013188 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 469383013189 MarR family; Region: MarR; pfam01047 469383013190 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383013191 MarR family; Region: MarR_2; cl17246 469383013192 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 469383013193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383013194 ATP binding site [chemical binding]; other site 469383013195 putative Mg++ binding site [ion binding]; other site 469383013196 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 469383013197 phosphoglyceromutase; Provisional; Region: PRK05434 469383013198 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 469383013199 triosephosphate isomerase; Provisional; Region: PRK14567 469383013200 substrate binding site [chemical binding]; other site 469383013201 dimer interface [polypeptide binding]; other site 469383013202 catalytic triad [active] 469383013203 Phosphoglycerate kinase; Region: PGK; pfam00162 469383013204 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 469383013205 substrate binding site [chemical binding]; other site 469383013206 hinge regions; other site 469383013207 ADP binding site [chemical binding]; other site 469383013208 catalytic site [active] 469383013209 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 469383013210 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 469383013211 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 469383013212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383013213 DNA-binding site [nucleotide binding]; DNA binding site 469383013214 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 469383013215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383013216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383013217 homodimer interface [polypeptide binding]; other site 469383013218 catalytic residue [active] 469383013219 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 469383013220 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 469383013221 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 469383013222 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 469383013223 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383013224 active site 469383013225 metal binding site [ion binding]; metal-binding site 469383013226 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 469383013227 shikimate kinase; Reviewed; Region: aroK; PRK00131 469383013228 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 469383013229 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 469383013230 GIY-YIG motif/motif A; other site 469383013231 active site 469383013232 catalytic site [active] 469383013233 putative DNA binding site [nucleotide binding]; other site 469383013234 metal binding site [ion binding]; metal-binding site 469383013235 UvrB/uvrC motif; Region: UVR; pfam02151 469383013236 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 469383013237 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 469383013238 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 469383013239 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 469383013240 N-acetyl-D-glucosamine binding site [chemical binding]; other site 469383013241 catalytic residue [active] 469383013242 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383013243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383013244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383013245 active site 469383013246 dimerization interface [polypeptide binding]; other site 469383013247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383013248 DNA binding site [nucleotide binding] 469383013249 PhoU domain; Region: PhoU; pfam01895 469383013250 PhoU domain; Region: PhoU; pfam01895 469383013251 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 469383013252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383013253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383013254 DNA binding site [nucleotide binding] 469383013255 domain linker motif; other site 469383013256 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 469383013257 ligand binding site [chemical binding]; other site 469383013258 dimerization interface [polypeptide binding]; other site 469383013259 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469383013260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383013261 Walker A/P-loop; other site 469383013262 ATP binding site [chemical binding]; other site 469383013263 Q-loop/lid; other site 469383013264 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469383013265 ABC transporter; Region: ABC_tran_2; pfam12848 469383013266 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469383013267 short chain dehydrogenase; Provisional; Region: PRK07201 469383013268 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 469383013269 putative NAD(P) binding site [chemical binding]; other site 469383013270 active site 469383013271 putative substrate binding site [chemical binding]; other site 469383013272 classical (c) SDRs; Region: SDR_c; cd05233 469383013273 NAD(P) binding site [chemical binding]; other site 469383013274 active site 469383013275 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 469383013276 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 469383013277 NAD binding site [chemical binding]; other site 469383013278 substrate binding site [chemical binding]; other site 469383013279 catalytic Zn binding site [ion binding]; other site 469383013280 structural Zn binding site [ion binding]; other site 469383013281 Domain of unknown function DUF59; Region: DUF59; pfam01883 469383013282 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383013283 active site 469383013284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383013285 Zn2+ binding site [ion binding]; other site 469383013286 Mg2+ binding site [ion binding]; other site 469383013287 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 469383013288 AAA ATPase domain; Region: AAA_16; pfam13191 469383013289 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383013290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383013291 DNA binding residues [nucleotide binding] 469383013292 dimerization interface [polypeptide binding]; other site 469383013293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383013294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383013295 Walker A/P-loop; other site 469383013296 ATP binding site [chemical binding]; other site 469383013297 Q-loop/lid; other site 469383013298 ABC transporter signature motif; other site 469383013299 Walker B; other site 469383013300 D-loop; other site 469383013301 H-loop/switch region; other site 469383013302 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383013303 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 469383013304 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 469383013305 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 469383013306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383013307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 469383013308 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 469383013309 ATP binding site [chemical binding]; other site 469383013310 Mg2+ binding site [ion binding]; other site 469383013311 G-X-G motif; other site 469383013312 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469383013313 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 469383013314 non-specific DNA interactions [nucleotide binding]; other site 469383013315 DNA binding site [nucleotide binding] 469383013316 sequence specific DNA binding site [nucleotide binding]; other site 469383013317 putative cAMP binding site [chemical binding]; other site 469383013318 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383013319 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 469383013320 N-acetyl-D-glucosamine binding site [chemical binding]; other site 469383013321 catalytic residue [active] 469383013322 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 469383013323 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 469383013324 active site 469383013325 Zn binding site [ion binding]; other site 469383013326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383013327 NAD(P) binding site [chemical binding]; other site 469383013328 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 469383013329 active site 469383013330 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 469383013331 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 469383013332 putative active site [active] 469383013333 putative FMN binding site [chemical binding]; other site 469383013334 putative substrate binding site [chemical binding]; other site 469383013335 putative catalytic residue [active] 469383013336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383013337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383013338 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 469383013339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383013340 NAD(P) binding site [chemical binding]; other site 469383013341 active site 469383013342 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 469383013343 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 469383013344 NAD(P) binding site [chemical binding]; other site 469383013345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383013346 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383013347 active site 469383013348 Phosphotransferase enzyme family; Region: APH; pfam01636 469383013349 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 469383013350 putative active site [active] 469383013351 putative substrate binding site [chemical binding]; other site 469383013352 ATP binding site [chemical binding]; other site 469383013353 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 469383013354 active site 469383013355 putative substrate binding region [chemical binding]; other site 469383013356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383013357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383013358 putative substrate translocation pore; other site 469383013359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383013360 MarR family; Region: MarR_2; pfam12802 469383013361 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 469383013362 SmpB-tmRNA interface; other site 469383013363 RNB domain; Region: RNB; pfam00773 469383013364 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 469383013365 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 469383013366 RNA binding site [nucleotide binding]; other site 469383013367 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 469383013368 C-terminal peptidase (prc); Region: prc; TIGR00225 469383013369 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 469383013370 protein binding site [polypeptide binding]; other site 469383013371 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 469383013372 Catalytic dyad [active] 469383013373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383013374 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 469383013375 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 469383013376 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 469383013377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383013378 Walker A/P-loop; other site 469383013379 ATP binding site [chemical binding]; other site 469383013380 Q-loop/lid; other site 469383013381 ABC transporter signature motif; other site 469383013382 Walker B; other site 469383013383 D-loop; other site 469383013384 H-loop/switch region; other site 469383013385 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 469383013386 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 469383013387 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 469383013388 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 469383013389 SnoaL-like domain; Region: SnoaL_4; pfam13577 469383013390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383013391 MarR family; Region: MarR_2; pfam12802 469383013392 quinolinate synthetase; Provisional; Region: PRK09375 469383013393 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 469383013394 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 469383013395 dimerization interface [polypeptide binding]; other site 469383013396 active site 469383013397 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 469383013398 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383013399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383013400 catalytic residue [active] 469383013401 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 469383013402 peptide chain release factor 2; Validated; Region: prfB; PRK00578 469383013403 This domain is found in peptide chain release factors; Region: PCRF; smart00937 469383013404 RF-1 domain; Region: RF-1; pfam00472 469383013405 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383013406 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383013407 DNA binding residues [nucleotide binding] 469383013408 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 469383013409 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 469383013410 SEC-C motif; Region: SEC-C; pfam02810 469383013411 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 469383013412 30S subunit binding site; other site 469383013413 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 469383013414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 469383013415 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 469383013416 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 469383013417 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 469383013418 active site 469383013419 Substrate binding site; other site 469383013420 Mg++ binding site; other site 469383013421 Predicted transcriptional regulator [Transcription]; Region: COG1959 469383013422 Transcriptional regulator; Region: Rrf2; pfam02082 469383013423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383013424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383013425 active site 469383013426 phosphorylation site [posttranslational modification] 469383013427 intermolecular recognition site; other site 469383013428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383013429 DNA binding residues [nucleotide binding] 469383013430 dimerization interface [polypeptide binding]; other site 469383013431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383013432 Histidine kinase; Region: HisKA_3; pfam07730 469383013433 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383013434 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383013435 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383013436 Walker A/P-loop; other site 469383013437 ATP binding site [chemical binding]; other site 469383013438 Q-loop/lid; other site 469383013439 ABC transporter signature motif; other site 469383013440 Walker B; other site 469383013441 D-loop; other site 469383013442 H-loop/switch region; other site 469383013443 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 469383013444 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 469383013445 homotetramer interface [polypeptide binding]; other site 469383013446 ligand binding site [chemical binding]; other site 469383013447 catalytic site [active] 469383013448 NAD binding site [chemical binding]; other site 469383013449 Adenosylhomocysteinase; Provisional; Region: PTZ00075 469383013450 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 469383013451 homotetramer interface [polypeptide binding]; other site 469383013452 ligand binding site [chemical binding]; other site 469383013453 catalytic site [active] 469383013454 NAD binding site [chemical binding]; other site 469383013455 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 469383013456 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 469383013457 DNA binding residues [nucleotide binding] 469383013458 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 469383013459 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469383013460 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 469383013461 dimer interface [polypeptide binding]; other site 469383013462 active site 469383013463 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 469383013464 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 469383013465 active site 469383013466 Substrate binding site; other site 469383013467 Mg++ binding site; other site 469383013468 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 469383013469 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 469383013470 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 469383013471 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 469383013472 Transcriptional regulator [Transcription]; Region: LytR; COG1316 469383013473 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 469383013474 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 469383013475 metal binding site [ion binding]; metal-binding site 469383013476 dimer interface [polypeptide binding]; other site 469383013477 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 469383013478 gamma subunit interface [polypeptide binding]; other site 469383013479 epsilon subunit interface [polypeptide binding]; other site 469383013480 LBP interface [polypeptide binding]; other site 469383013481 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 469383013482 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 469383013483 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 469383013484 alpha subunit interaction interface [polypeptide binding]; other site 469383013485 Walker A motif; other site 469383013486 ATP binding site [chemical binding]; other site 469383013487 Walker B motif; other site 469383013488 inhibitor binding site; inhibition site 469383013489 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 469383013490 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 469383013491 core domain interface [polypeptide binding]; other site 469383013492 delta subunit interface [polypeptide binding]; other site 469383013493 epsilon subunit interface [polypeptide binding]; other site 469383013494 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 469383013495 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 469383013496 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 469383013497 beta subunit interaction interface [polypeptide binding]; other site 469383013498 Walker A motif; other site 469383013499 ATP binding site [chemical binding]; other site 469383013500 Walker B motif; other site 469383013501 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 469383013502 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 469383013503 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 469383013504 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 469383013505 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 469383013506 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 469383013507 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 469383013508 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 469383013509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383013510 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 469383013511 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 469383013512 putative catalytic motif [active] 469383013513 substrate binding site [chemical binding]; other site 469383013514 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 469383013515 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 469383013516 dimer interface [polypeptide binding]; other site 469383013517 active site 469383013518 glycine-pyridoxal phosphate binding site [chemical binding]; other site 469383013519 folate binding site [chemical binding]; other site 469383013520 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 469383013521 MarR family; Region: MarR_2; pfam12802 469383013522 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 469383013523 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 469383013524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383013525 peptide chain release factor 1; Validated; Region: prfA; PRK00591 469383013526 PCRF domain; Region: PCRF; pfam03462 469383013527 RF-1 domain; Region: RF-1; pfam00472 469383013528 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 469383013529 CARDB; Region: CARDB; pfam07705 469383013530 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 469383013531 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 469383013532 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 469383013533 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 469383013534 Ligand Binding Site [chemical binding]; other site 469383013535 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 469383013536 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 469383013537 Ligand binding site [chemical binding]; other site 469383013538 Electron transfer flavoprotein domain; Region: ETF; pfam01012 469383013539 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 469383013540 B12 binding site [chemical binding]; other site 469383013541 cobalt ligand [ion binding]; other site 469383013542 multifunctional aminopeptidase A; Provisional; Region: PRK00913 469383013543 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 469383013544 interface (dimer of trimers) [polypeptide binding]; other site 469383013545 Substrate-binding/catalytic site; other site 469383013546 Zn-binding sites [ion binding]; other site 469383013547 putative acyltransferase; Provisional; Region: PRK05790 469383013548 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383013549 dimer interface [polypeptide binding]; other site 469383013550 active site 469383013551 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 469383013552 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 469383013553 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383013554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383013555 active site 469383013556 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 469383013557 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 469383013558 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469383013559 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 469383013560 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 469383013561 Walker A; other site 469383013562 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 469383013563 G4 box; other site 469383013564 G5 box; other site 469383013565 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 469383013566 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 469383013567 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 469383013568 trimer interface [polypeptide binding]; other site 469383013569 active site 469383013570 substrate binding site [chemical binding]; other site 469383013571 CoA binding site [chemical binding]; other site 469383013572 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383013573 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 469383013574 Walker A/P-loop; other site 469383013575 ATP binding site [chemical binding]; other site 469383013576 Q-loop/lid; other site 469383013577 ABC transporter signature motif; other site 469383013578 Walker B; other site 469383013579 D-loop; other site 469383013580 H-loop/switch region; other site 469383013581 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383013582 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383013583 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383013584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383013585 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383013586 Uncharacterized conserved protein [Function unknown]; Region: COG1543 469383013587 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 469383013588 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383013589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383013590 S-adenosylmethionine binding site [chemical binding]; other site 469383013591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383013592 S-adenosylmethionine binding site [chemical binding]; other site 469383013593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 469383013594 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 469383013595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383013596 DNA-binding site [nucleotide binding]; DNA binding site 469383013597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383013598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383013599 catalytic residue [active] 469383013600 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 469383013601 DNA photolyase; Region: DNA_photolyase; pfam00875 469383013602 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383013603 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 469383013604 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383013605 conserved repeat domain; Region: B_ant_repeat; TIGR01451 469383013606 Domain of unknown function DUF11; Region: DUF11; cl17728 469383013607 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383013608 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 469383013609 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 469383013610 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 469383013611 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 469383013612 cell division protein FtsZ; Validated; Region: PRK09330 469383013613 nucleotide binding site [chemical binding]; other site 469383013614 SulA interaction site; other site 469383013615 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 469383013616 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 469383013617 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 469383013618 Magnesium ion binding site [ion binding]; other site 469383013619 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 469383013620 DTAP/Switch II; other site 469383013621 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 469383013622 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 469383013623 DTAP/Switch II; other site 469383013624 Switch I; other site 469383013625 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383013626 UPF0126 domain; Region: UPF0126; pfam03458 469383013627 Predicted membrane protein [Function unknown]; Region: COG2860 469383013628 UPF0126 domain; Region: UPF0126; pfam03458 469383013629 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383013630 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383013631 DNA binding residues [nucleotide binding] 469383013632 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 469383013633 cyclase homology domain; Region: CHD; cd07302 469383013634 nucleotidyl binding site; other site 469383013635 metal binding site [ion binding]; metal-binding site 469383013636 dimer interface [polypeptide binding]; other site 469383013637 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383013638 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383013639 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383013640 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 469383013641 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383013642 substrate binding site [chemical binding]; other site 469383013643 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 469383013644 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 469383013645 active site 469383013646 intersubunit interface [polypeptide binding]; other site 469383013647 catalytic residue [active] 469383013648 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 469383013649 active site 469383013650 catalytic residues [active] 469383013651 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383013652 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383013653 dimerization interface [polypeptide binding]; other site 469383013654 putative Zn2+ binding site [ion binding]; other site 469383013655 putative DNA binding site [nucleotide binding]; other site 469383013656 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 469383013657 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 469383013658 C-terminal domain interface [polypeptide binding]; other site 469383013659 GSH binding site (G-site) [chemical binding]; other site 469383013660 dimer interface [polypeptide binding]; other site 469383013661 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 469383013662 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 469383013663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383013664 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469383013665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383013666 DNA binding residues [nucleotide binding] 469383013667 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 469383013668 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383013669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383013670 metal binding site [ion binding]; metal-binding site 469383013671 I-site; other site 469383013672 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 469383013673 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 469383013674 dimer interface [polypeptide binding]; other site 469383013675 putative functional site; other site 469383013676 putative MPT binding site; other site 469383013677 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 469383013678 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 469383013679 putative active site [active] 469383013680 RibD C-terminal domain; Region: RibD_C; cl17279 469383013681 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 469383013682 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 469383013683 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 469383013684 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 469383013685 putative active site [active] 469383013686 catalytic residue [active] 469383013687 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 469383013688 active site 469383013689 dimer interface [polypeptide binding]; other site 469383013690 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469383013691 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 469383013692 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 469383013693 putative active site [active] 469383013694 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 469383013695 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 469383013696 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 469383013697 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 469383013698 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 469383013699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383013700 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383013701 NAD(P) binding site [chemical binding]; other site 469383013702 active site 469383013703 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 469383013704 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 469383013705 dimer interface [polypeptide binding]; other site 469383013706 active site 469383013707 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 469383013708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383013709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383013710 active site 469383013711 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 469383013712 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383013713 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383013714 NlpC/P60 family; Region: NLPC_P60; cl17555 469383013715 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 469383013716 dimer interface [polypeptide binding]; other site 469383013717 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 469383013718 active site 469383013719 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383013720 substrate binding site [chemical binding]; other site 469383013721 catalytic residue [active] 469383013722 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 469383013723 FAD binding domain; Region: FAD_binding_4; pfam01565 469383013724 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 469383013725 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 469383013726 active site residue [active] 469383013727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383013728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383013729 dimerization interface [polypeptide binding]; other site 469383013730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383013731 dimer interface [polypeptide binding]; other site 469383013732 phosphorylation site [posttranslational modification] 469383013733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383013734 ATP binding site [chemical binding]; other site 469383013735 Mg2+ binding site [ion binding]; other site 469383013736 G-X-G motif; other site 469383013737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383013738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383013739 active site 469383013740 phosphorylation site [posttranslational modification] 469383013741 intermolecular recognition site; other site 469383013742 dimerization interface [polypeptide binding]; other site 469383013743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383013744 DNA binding site [nucleotide binding] 469383013745 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 469383013746 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 469383013747 TPP-binding site [chemical binding]; other site 469383013748 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 469383013749 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 469383013750 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 469383013751 PYR/PP interface [polypeptide binding]; other site 469383013752 TPP binding site [chemical binding]; other site 469383013753 dimer interface [polypeptide binding]; other site 469383013754 substrate binding site [chemical binding]; other site 469383013755 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 469383013756 DNA-binding site [nucleotide binding]; DNA binding site 469383013757 RNA-binding motif; other site 469383013758 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383013759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383013760 metal binding site [ion binding]; metal-binding site 469383013761 active site 469383013762 I-site; other site 469383013763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383013764 Zn2+ binding site [ion binding]; other site 469383013765 Mg2+ binding site [ion binding]; other site 469383013766 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 469383013767 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 469383013768 active site 469383013769 DNA binding site [nucleotide binding] 469383013770 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 469383013771 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 469383013772 DNA binding site [nucleotide binding] 469383013773 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 469383013774 nucleotide binding site [chemical binding]; other site 469383013775 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 469383013776 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 469383013777 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 469383013778 catalytic core [active] 469383013779 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 469383013780 classical (c) SDRs; Region: SDR_c; cd05233 469383013781 NAD(P) binding site [chemical binding]; other site 469383013782 active site 469383013783 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 469383013784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383013785 S-adenosylmethionine binding site [chemical binding]; other site 469383013786 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 469383013787 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 469383013788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 469383013789 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 469383013790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383013791 substrate binding site [chemical binding]; other site 469383013792 oxyanion hole (OAH) forming residues; other site 469383013793 trimer interface [polypeptide binding]; other site 469383013794 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 469383013795 active site 469383013796 HIGH motif; other site 469383013797 nucleotide binding site [chemical binding]; other site 469383013798 active site 469383013799 KMSKS motif; other site 469383013800 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 469383013801 DEAD-like helicases superfamily; Region: DEXDc; smart00487 469383013802 ATP binding site [chemical binding]; other site 469383013803 Mg++ binding site [ion binding]; other site 469383013804 motif III; other site 469383013805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383013806 nucleotide binding region [chemical binding]; other site 469383013807 ATP-binding site [chemical binding]; other site 469383013808 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383013809 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 469383013810 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383013811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383013812 Walker A/P-loop; other site 469383013813 ATP binding site [chemical binding]; other site 469383013814 Q-loop/lid; other site 469383013815 ABC transporter signature motif; other site 469383013816 Walker B; other site 469383013817 D-loop; other site 469383013818 H-loop/switch region; other site 469383013819 FtsX-like permease family; Region: FtsX; pfam02687 469383013820 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383013821 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 469383013822 Transcriptional regulators [Transcription]; Region: PurR; COG1609 469383013823 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 469383013824 DNA binding site [nucleotide binding] 469383013825 domain linker motif; other site 469383013826 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383013827 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 469383013828 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 469383013829 active site 469383013830 Amino acid permease; Region: AA_permease; pfam00324 469383013831 Predicted amidohydrolase [General function prediction only]; Region: COG0388 469383013832 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 469383013833 active site 469383013834 catalytic triad [active] 469383013835 dimer interface [polypeptide binding]; other site 469383013836 methionine sulfoxide reductase A; Provisional; Region: PRK00058 469383013837 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 469383013838 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 469383013839 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 469383013840 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 469383013841 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 469383013842 metal binding site 2 [ion binding]; metal-binding site 469383013843 putative DNA binding helix; other site 469383013844 metal binding site 1 [ion binding]; metal-binding site 469383013845 dimer interface [polypeptide binding]; other site 469383013846 structural Zn2+ binding site [ion binding]; other site 469383013847 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 469383013848 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 469383013849 active site 469383013850 catalytic residues [active] 469383013851 metal binding site [ion binding]; metal-binding site 469383013852 DmpG-like communication domain; Region: DmpG_comm; pfam07836 469383013853 acetaldehyde dehydrogenase; Validated; Region: PRK08300 469383013854 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 469383013855 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 469383013856 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 469383013857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383013858 NAD(P) binding site [chemical binding]; other site 469383013859 active site 469383013860 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 469383013861 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383013862 Zn binding site [ion binding]; other site 469383013863 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 469383013864 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383013865 Zn binding site [ion binding]; other site 469383013866 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383013867 Sulfatase; Region: Sulfatase; cl17466 469383013868 Sulfatase; Region: Sulfatase; cl17466 469383013869 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 469383013870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383013871 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383013872 DNA binding residues [nucleotide binding] 469383013873 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383013874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383013875 NAD(P) binding site [chemical binding]; other site 469383013876 active site 469383013877 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383013878 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383013879 DNA binding residues [nucleotide binding] 469383013880 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 469383013881 active site 469383013882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383013883 Histidine kinase; Region: HisKA_3; pfam07730 469383013884 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383013885 ATP binding site [chemical binding]; other site 469383013886 Mg2+ binding site [ion binding]; other site 469383013887 G-X-G motif; other site 469383013888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383013889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383013890 active site 469383013891 phosphorylation site [posttranslational modification] 469383013892 intermolecular recognition site; other site 469383013893 dimerization interface [polypeptide binding]; other site 469383013894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383013895 DNA binding residues [nucleotide binding] 469383013896 dimerization interface [polypeptide binding]; other site 469383013897 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383013898 FAD binding domain; Region: FAD_binding_4; pfam01565 469383013899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383013900 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383013901 active site 469383013902 PemK-like protein; Region: PemK; pfam02452 469383013903 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 469383013904 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 469383013905 Ycf48-like protein; Provisional; Region: PRK13684 469383013906 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 469383013907 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 469383013908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383013909 Walker A motif; other site 469383013910 ATP binding site [chemical binding]; other site 469383013911 Walker B motif; other site 469383013912 arginine finger; other site 469383013913 Peptidase family M41; Region: Peptidase_M41; pfam01434 469383013914 PBP superfamily domain; Region: PBP_like_2; cl17296 469383013915 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 469383013916 PBP superfamily domain; Region: PBP_like_2; cl17296 469383013917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383013918 dimer interface [polypeptide binding]; other site 469383013919 conserved gate region; other site 469383013920 ABC-ATPase subunit interface; other site 469383013921 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 469383013922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383013923 dimer interface [polypeptide binding]; other site 469383013924 conserved gate region; other site 469383013925 putative PBP binding loops; other site 469383013926 ABC-ATPase subunit interface; other site 469383013927 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 469383013928 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 469383013929 Walker A/P-loop; other site 469383013930 ATP binding site [chemical binding]; other site 469383013931 Q-loop/lid; other site 469383013932 ABC transporter signature motif; other site 469383013933 Walker B; other site 469383013934 D-loop; other site 469383013935 H-loop/switch region; other site 469383013936 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 469383013937 Phosphoesterase family; Region: Phosphoesterase; pfam04185 469383013938 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 469383013939 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 469383013940 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 469383013941 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 469383013942 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 469383013943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383013944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383013945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383013946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383013947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383013948 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383013949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383013950 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 469383013951 Strictosidine synthase; Region: Str_synth; pfam03088 469383013952 short chain dehydrogenase; Provisional; Region: PRK06138 469383013953 classical (c) SDRs; Region: SDR_c; cd05233 469383013954 NAD(P) binding site [chemical binding]; other site 469383013955 active site 469383013956 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383013957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383013958 DNA-binding site [nucleotide binding]; DNA binding site 469383013959 FCD domain; Region: FCD; pfam07729 469383013960 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 469383013961 Predicted acyl esterases [General function prediction only]; Region: COG2936 469383013962 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383013963 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383013964 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 469383013965 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 469383013966 Response regulator receiver domain; Region: Response_reg; pfam00072 469383013967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383013968 active site 469383013969 phosphorylation site [posttranslational modification] 469383013970 intermolecular recognition site; other site 469383013971 dimerization interface [polypeptide binding]; other site 469383013972 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 469383013973 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 469383013974 hypothetical protein; Provisional; Region: PRK08392 469383013975 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 469383013976 active site 469383013977 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 469383013978 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 469383013979 DXD motif; other site 469383013980 CoA binding domain; Region: CoA_binding; cl17356 469383013981 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 469383013982 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383013983 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 469383013984 Walker A/P-loop; other site 469383013985 ATP binding site [chemical binding]; other site 469383013986 Q-loop/lid; other site 469383013987 ABC transporter signature motif; other site 469383013988 Walker B; other site 469383013989 D-loop; other site 469383013990 short chain dehydrogenase; Validated; Region: PRK08324 469383013991 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 469383013992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383013993 NAD(P) binding site [chemical binding]; other site 469383013994 active site 469383013995 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 469383013996 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 469383013997 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 469383013998 N- and C-terminal domain interface [polypeptide binding]; other site 469383013999 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 469383014000 active site 469383014001 putative catalytic site [active] 469383014002 metal binding site [ion binding]; metal-binding site 469383014003 ATP binding site [chemical binding]; other site 469383014004 carbohydrate binding site [chemical binding]; other site 469383014005 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 469383014006 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 469383014007 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 469383014008 hexamer (dimer of trimers) interface [polypeptide binding]; other site 469383014009 substrate binding site [chemical binding]; other site 469383014010 trimer interface [polypeptide binding]; other site 469383014011 Mn binding site [ion binding]; other site 469383014012 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 469383014013 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 469383014014 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 469383014015 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 469383014016 Cysteine-rich domain; Region: CCG; pfam02754 469383014017 Cysteine-rich domain; Region: CCG; pfam02754 469383014018 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 469383014019 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 469383014020 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 469383014021 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 469383014022 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 469383014023 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 469383014024 oligomeric interface; other site 469383014025 putative active site [active] 469383014026 homodimer interface [polypeptide binding]; other site 469383014027 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 469383014028 CoenzymeA binding site [chemical binding]; other site 469383014029 subunit interaction site [polypeptide binding]; other site 469383014030 PHB binding site; other site 469383014031 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 469383014032 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 469383014033 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 469383014034 DEAD-like helicases superfamily; Region: DEXDc; smart00487 469383014035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383014036 ATP binding site [chemical binding]; other site 469383014037 putative Mg++ binding site [ion binding]; other site 469383014038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383014039 nucleotide binding region [chemical binding]; other site 469383014040 ATP-binding site [chemical binding]; other site 469383014041 Secretory lipase; Region: LIP; pfam03583 469383014042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383014043 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 469383014044 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 469383014045 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 469383014046 active site 469383014047 HIGH motif; other site 469383014048 nucleotide binding site [chemical binding]; other site 469383014049 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 469383014050 active site 469383014051 KMSKS motif; other site 469383014052 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 469383014053 tRNA binding surface [nucleotide binding]; other site 469383014054 anticodon binding site; other site 469383014055 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 469383014056 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 469383014057 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 469383014058 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 469383014059 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 469383014060 active site 469383014061 catalytic residues [active] 469383014062 metal binding site [ion binding]; metal-binding site 469383014063 DmpG-like communication domain; Region: DmpG_comm; pfam07836 469383014064 acetaldehyde dehydrogenase; Validated; Region: PRK08300 469383014065 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 469383014066 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 469383014067 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 469383014068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383014069 S-adenosylmethionine binding site [chemical binding]; other site 469383014070 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 469383014071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 469383014072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383014073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014074 Integral membrane protein TerC family; Region: TerC; cl10468 469383014075 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 469383014076 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383014077 active site 469383014078 metal binding site [ion binding]; metal-binding site 469383014079 CGNR zinc finger; Region: zf-CGNR; pfam11706 469383014080 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383014081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014082 dimer interface [polypeptide binding]; other site 469383014083 conserved gate region; other site 469383014084 putative PBP binding loops; other site 469383014085 ABC-ATPase subunit interface; other site 469383014086 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 469383014087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 469383014088 substrate binding pocket [chemical binding]; other site 469383014089 membrane-bound complex binding site; other site 469383014090 hinge residues; other site 469383014091 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383014092 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383014093 Walker A/P-loop; other site 469383014094 ATP binding site [chemical binding]; other site 469383014095 Q-loop/lid; other site 469383014096 ABC transporter signature motif; other site 469383014097 Walker B; other site 469383014098 D-loop; other site 469383014099 H-loop/switch region; other site 469383014100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383014101 NAD(P) binding site [chemical binding]; other site 469383014102 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383014103 active site 469383014104 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 469383014105 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383014106 active site 469383014107 metal binding site [ion binding]; metal-binding site 469383014108 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 469383014109 active site 469383014110 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 469383014111 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 469383014112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383014113 Histidine kinase; Region: HisKA_3; pfam07730 469383014114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383014115 ATP binding site [chemical binding]; other site 469383014116 Mg2+ binding site [ion binding]; other site 469383014117 G-X-G motif; other site 469383014118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383014119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383014120 active site 469383014121 phosphorylation site [posttranslational modification] 469383014122 intermolecular recognition site; other site 469383014123 dimerization interface [polypeptide binding]; other site 469383014124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383014125 DNA binding residues [nucleotide binding] 469383014126 dimerization interface [polypeptide binding]; other site 469383014127 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 469383014128 gating phenylalanine in ion channel; other site 469383014129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383014130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383014131 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 469383014132 putative dimerization interface [polypeptide binding]; other site 469383014133 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383014134 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383014135 Walker A/P-loop; other site 469383014136 ATP binding site [chemical binding]; other site 469383014137 Q-loop/lid; other site 469383014138 ABC transporter signature motif; other site 469383014139 Walker B; other site 469383014140 D-loop; other site 469383014141 H-loop/switch region; other site 469383014142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383014143 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 469383014144 FtsX-like permease family; Region: FtsX; pfam02687 469383014145 FtsX-like permease family; Region: FtsX; pfam02687 469383014146 AAA ATPase domain; Region: AAA_16; pfam13191 469383014147 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383014148 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383014149 NAD(P) binding site [chemical binding]; other site 469383014150 catalytic residues [active] 469383014151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383014152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014153 Predicted amidohydrolase [General function prediction only]; Region: COG0388 469383014154 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 469383014155 active site 469383014156 catalytic triad [active] 469383014157 dimer interface [polypeptide binding]; other site 469383014158 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 469383014159 Amidohydrolase; Region: Amidohydro_2; pfam04909 469383014160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383014161 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 469383014162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383014163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014164 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 469383014165 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 469383014166 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 469383014167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 469383014168 catalytic residue [active] 469383014169 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383014170 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383014171 Walker A/P-loop; other site 469383014172 ATP binding site [chemical binding]; other site 469383014173 Q-loop/lid; other site 469383014174 ABC transporter signature motif; other site 469383014175 Walker B; other site 469383014176 D-loop; other site 469383014177 H-loop/switch region; other site 469383014178 TOBE domain; Region: TOBE_2; pfam08402 469383014179 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383014180 homotrimer interaction site [polypeptide binding]; other site 469383014181 putative active site [active] 469383014182 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383014183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014184 dimer interface [polypeptide binding]; other site 469383014185 conserved gate region; other site 469383014186 putative PBP binding loops; other site 469383014187 ABC-ATPase subunit interface; other site 469383014188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014189 dimer interface [polypeptide binding]; other site 469383014190 conserved gate region; other site 469383014191 putative PBP binding loops; other site 469383014192 ABC-ATPase subunit interface; other site 469383014193 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383014194 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 469383014195 classical (c) SDRs; Region: SDR_c; cd05233 469383014196 NAD(P) binding site [chemical binding]; other site 469383014197 active site 469383014198 alpha-galactosidase; Provisional; Region: PRK15076 469383014199 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 469383014200 NAD binding site [chemical binding]; other site 469383014201 sugar binding site [chemical binding]; other site 469383014202 divalent metal binding site [ion binding]; other site 469383014203 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 469383014204 dimer interface [polypeptide binding]; other site 469383014205 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 469383014206 classical (c) SDRs; Region: SDR_c; cd05233 469383014207 NAD(P) binding site [chemical binding]; other site 469383014208 active site 469383014209 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383014210 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383014211 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383014212 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 469383014213 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 469383014214 nudix motif; other site 469383014215 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 469383014216 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 469383014217 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383014218 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383014219 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383014220 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 469383014221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383014222 NAD(P) binding site [chemical binding]; other site 469383014223 active site 469383014224 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 469383014225 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 469383014226 Walker A/P-loop; other site 469383014227 ATP binding site [chemical binding]; other site 469383014228 Q-loop/lid; other site 469383014229 ABC transporter signature motif; other site 469383014230 Walker B; other site 469383014231 D-loop; other site 469383014232 H-loop/switch region; other site 469383014233 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383014234 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 469383014235 Walker A/P-loop; other site 469383014236 ATP binding site [chemical binding]; other site 469383014237 Q-loop/lid; other site 469383014238 ABC transporter signature motif; other site 469383014239 Walker B; other site 469383014240 D-loop; other site 469383014241 H-loop/switch region; other site 469383014242 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 469383014243 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 469383014244 TM-ABC transporter signature motif; other site 469383014245 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383014246 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 469383014247 TM-ABC transporter signature motif; other site 469383014248 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 469383014249 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383014250 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 469383014251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 469383014252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 469383014253 protein binding site [polypeptide binding]; other site 469383014254 von Willebrand factor type A domain; Region: VWA_2; pfam13519 469383014255 metal ion-dependent adhesion site (MIDAS); other site 469383014256 MoxR-like ATPases [General function prediction only]; Region: COG0714 469383014257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383014258 ATP binding site [chemical binding]; other site 469383014259 Walker A motif; other site 469383014260 Walker B motif; other site 469383014261 arginine finger; other site 469383014262 Protein of unknown function DUF58; Region: DUF58; pfam01882 469383014263 von Willebrand factor type A domain; Region: VWA_2; pfam13519 469383014264 von Willebrand factor type A domain; Region: VWA_2; pfam13519 469383014265 metal ion-dependent adhesion site (MIDAS); other site 469383014266 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 469383014267 active site 469383014268 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 469383014269 YciI-like protein; Reviewed; Region: PRK12866 469383014270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 469383014271 MarR family; Region: MarR_2; cl17246 469383014272 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 469383014273 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383014274 active site 469383014275 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 469383014276 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 469383014277 Walker A/P-loop; other site 469383014278 ATP binding site [chemical binding]; other site 469383014279 Q-loop/lid; other site 469383014280 ABC transporter signature motif; other site 469383014281 Walker B; other site 469383014282 D-loop; other site 469383014283 H-loop/switch region; other site 469383014284 TOBE domain; Region: TOBE; pfam03459 469383014285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014286 dimer interface [polypeptide binding]; other site 469383014287 conserved gate region; other site 469383014288 putative PBP binding loops; other site 469383014289 ABC-ATPase subunit interface; other site 469383014290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014291 dimer interface [polypeptide binding]; other site 469383014292 conserved gate region; other site 469383014293 putative PBP binding loops; other site 469383014294 ABC-ATPase subunit interface; other site 469383014295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 469383014296 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 469383014297 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 469383014298 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 469383014299 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383014300 Ligand Binding Site [chemical binding]; other site 469383014301 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 469383014302 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 469383014303 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383014304 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 469383014305 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383014306 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383014307 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383014308 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383014309 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 469383014310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 469383014311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 469383014312 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 469383014313 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383014314 amino acid transporter; Region: 2A0306; TIGR00909 469383014315 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 469383014316 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 469383014317 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383014318 PYR/PP interface [polypeptide binding]; other site 469383014319 dimer interface [polypeptide binding]; other site 469383014320 TPP binding site [chemical binding]; other site 469383014321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383014322 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 469383014323 TPP-binding site [chemical binding]; other site 469383014324 DNA polymerase II large subunit; Validated; Region: PRK04023 469383014325 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383014326 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383014327 metal binding site [ion binding]; metal-binding site 469383014328 active site 469383014329 I-site; other site 469383014330 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 469383014331 Calx-beta domain; Region: Calx-beta; cl02522 469383014332 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 469383014333 putative NAD(P) binding site [chemical binding]; other site 469383014334 active site 469383014335 putative substrate binding site [chemical binding]; other site 469383014336 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 469383014337 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 469383014338 active site 469383014339 nucleophile elbow; other site 469383014340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383014341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383014342 active site 469383014343 phosphorylation site [posttranslational modification] 469383014344 intermolecular recognition site; other site 469383014345 dimerization interface [polypeptide binding]; other site 469383014346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383014347 DNA binding residues [nucleotide binding] 469383014348 dimerization interface [polypeptide binding]; other site 469383014349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383014350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014351 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 469383014352 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 469383014353 acyl-activating enzyme (AAE) consensus motif; other site 469383014354 putative AMP binding site [chemical binding]; other site 469383014355 putative active site [active] 469383014356 putative CoA binding site [chemical binding]; other site 469383014357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383014358 active site 469383014359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 469383014360 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 469383014361 substrate binding site [chemical binding]; other site 469383014362 oxyanion hole (OAH) forming residues; other site 469383014363 trimer interface [polypeptide binding]; other site 469383014364 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 469383014365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383014366 Walker A/P-loop; other site 469383014367 ATP binding site [chemical binding]; other site 469383014368 Q-loop/lid; other site 469383014369 ABC transporter signature motif; other site 469383014370 Walker B; other site 469383014371 D-loop; other site 469383014372 H-loop/switch region; other site 469383014373 TOBE domain; Region: TOBE_2; pfam08402 469383014374 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 469383014375 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 469383014376 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 469383014377 Predicted acyl esterases [General function prediction only]; Region: COG2936 469383014378 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 469383014379 Histidine kinase; Region: HisKA_3; pfam07730 469383014380 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383014381 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 469383014382 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 469383014383 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 469383014384 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 469383014385 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 469383014386 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 469383014387 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 469383014388 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 469383014389 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 469383014390 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 469383014391 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383014392 Baseplate J-like protein; Region: Baseplate_J; cl01294 469383014393 Bacterial transcriptional activator domain; Region: BTAD; smart01043 469383014394 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 469383014395 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 469383014396 putative active site [active] 469383014397 putative metal binding site [ion binding]; other site 469383014398 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383014399 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 469383014400 active site 469383014401 catalytic triad [active] 469383014402 oxyanion hole [active] 469383014403 PAS domain; Region: PAS_9; pfam13426 469383014404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383014405 Histidine kinase; Region: HisKA_3; pfam07730 469383014406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383014407 ATP binding site [chemical binding]; other site 469383014408 Mg2+ binding site [ion binding]; other site 469383014409 G-X-G motif; other site 469383014410 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383014411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383014412 active site 469383014413 phosphorylation site [posttranslational modification] 469383014414 intermolecular recognition site; other site 469383014415 dimerization interface [polypeptide binding]; other site 469383014416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383014417 dimerization interface [polypeptide binding]; other site 469383014418 DNA binding residues [nucleotide binding] 469383014419 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 469383014420 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 469383014421 active site 469383014422 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 469383014423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383014425 Domain of unknown function DUF77; Region: DUF77; pfam01910 469383014426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383014427 dimerization interface [polypeptide binding]; other site 469383014428 putative DNA binding site [nucleotide binding]; other site 469383014429 putative Zn2+ binding site [ion binding]; other site 469383014430 XFP N-terminal domain; Region: XFP_N; pfam09364 469383014431 putative phosphoketolase; Provisional; Region: PRK05261 469383014432 XFP C-terminal domain; Region: XFP_C; pfam09363 469383014433 Acetokinase family; Region: Acetate_kinase; cl17229 469383014434 propionate/acetate kinase; Provisional; Region: PRK12379 469383014435 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 469383014436 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 469383014437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014438 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 469383014439 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 469383014440 Fatty acid desaturase; Region: FA_desaturase; pfam00487 469383014441 Di-iron ligands [ion binding]; other site 469383014442 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 469383014443 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 469383014444 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383014445 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383014446 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383014447 TM-ABC transporter signature motif; other site 469383014448 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 469383014449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383014450 Walker A/P-loop; other site 469383014451 ATP binding site [chemical binding]; other site 469383014452 Q-loop/lid; other site 469383014453 ABC transporter signature motif; other site 469383014454 Walker B; other site 469383014455 D-loop; other site 469383014456 H-loop/switch region; other site 469383014457 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383014458 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 469383014459 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 469383014460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383014461 putative DNA binding site [nucleotide binding]; other site 469383014462 putative Zn2+ binding site [ion binding]; other site 469383014463 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 469383014464 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383014465 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383014466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 469383014467 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469383014468 dimer interface [polypeptide binding]; other site 469383014469 active site 469383014470 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469383014471 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 469383014472 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 469383014473 AAA domain; Region: AAA_33; pfam13671 469383014474 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 469383014475 DNA-binding site [nucleotide binding]; DNA binding site 469383014476 RNA-binding motif; other site 469383014477 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383014478 homotrimer interaction site [polypeptide binding]; other site 469383014479 putative active site [active] 469383014480 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 469383014481 Cupin domain; Region: Cupin_2; pfam07883 469383014482 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 469383014483 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383014484 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383014485 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 469383014486 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 469383014487 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 469383014488 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 469383014489 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 469383014490 dimerization interface [polypeptide binding]; other site 469383014491 ligand binding site [chemical binding]; other site 469383014492 NADP binding site [chemical binding]; other site 469383014493 catalytic site [active] 469383014494 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 469383014495 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 469383014496 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014497 Walker A/P-loop; other site 469383014498 ATP binding site [chemical binding]; other site 469383014499 Q-loop/lid; other site 469383014500 ABC transporter signature motif; other site 469383014501 Walker B; other site 469383014502 D-loop; other site 469383014503 H-loop/switch region; other site 469383014504 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 469383014505 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383014506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014507 Walker A/P-loop; other site 469383014508 ATP binding site [chemical binding]; other site 469383014509 Q-loop/lid; other site 469383014510 ABC transporter signature motif; other site 469383014511 Walker B; other site 469383014512 D-loop; other site 469383014513 H-loop/switch region; other site 469383014514 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014515 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383014516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014517 dimer interface [polypeptide binding]; other site 469383014518 conserved gate region; other site 469383014519 putative PBP binding loops; other site 469383014520 ABC-ATPase subunit interface; other site 469383014521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383014522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014523 dimer interface [polypeptide binding]; other site 469383014524 conserved gate region; other site 469383014525 putative PBP binding loops; other site 469383014526 ABC-ATPase subunit interface; other site 469383014527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383014528 S-adenosylmethionine binding site [chemical binding]; other site 469383014529 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383014530 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383014531 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 469383014532 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383014533 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383014534 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383014535 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 469383014536 PBP superfamily domain; Region: PBP_like_2; cl17296 469383014537 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 469383014538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014539 ABC-ATPase subunit interface; other site 469383014540 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 469383014541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014542 dimer interface [polypeptide binding]; other site 469383014543 conserved gate region; other site 469383014544 putative PBP binding loops; other site 469383014545 ABC-ATPase subunit interface; other site 469383014546 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 469383014547 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 469383014548 Walker A/P-loop; other site 469383014549 ATP binding site [chemical binding]; other site 469383014550 Q-loop/lid; other site 469383014551 ABC transporter signature motif; other site 469383014552 Walker B; other site 469383014553 D-loop; other site 469383014554 H-loop/switch region; other site 469383014555 Phosphoesterase family; Region: Phosphoesterase; pfam04185 469383014556 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 469383014557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383014558 active site 469383014559 phosphorylation site [posttranslational modification] 469383014560 intermolecular recognition site; other site 469383014561 dimerization interface [polypeptide binding]; other site 469383014562 ANTAR domain; Region: ANTAR; pfam03861 469383014563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 469383014564 Histidine kinase; Region: HisKA_2; pfam07568 469383014565 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 469383014566 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 469383014567 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 469383014568 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 469383014569 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 469383014570 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 469383014571 Walker A/P-loop; other site 469383014572 ATP binding site [chemical binding]; other site 469383014573 Q-loop/lid; other site 469383014574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383014575 D-loop; other site 469383014576 H-loop/switch region; other site 469383014577 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 469383014578 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 469383014579 Walker A/P-loop; other site 469383014580 ATP binding site [chemical binding]; other site 469383014581 Q-loop/lid; other site 469383014582 ABC transporter signature motif; other site 469383014583 Walker B; other site 469383014584 D-loop; other site 469383014585 H-loop/switch region; other site 469383014586 YrhK-like protein; Region: YrhK; pfam14145 469383014587 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 469383014588 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 469383014589 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 469383014590 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 469383014591 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 469383014592 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 469383014593 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383014594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014595 Walker A/P-loop; other site 469383014596 ATP binding site [chemical binding]; other site 469383014597 Q-loop/lid; other site 469383014598 ABC transporter signature motif; other site 469383014599 Walker B; other site 469383014600 D-loop; other site 469383014601 H-loop/switch region; other site 469383014602 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014603 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383014604 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014605 Walker A/P-loop; other site 469383014606 ATP binding site [chemical binding]; other site 469383014607 Q-loop/lid; other site 469383014608 ABC transporter signature motif; other site 469383014609 Walker B; other site 469383014610 D-loop; other site 469383014611 H-loop/switch region; other site 469383014612 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014613 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383014614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014615 putative PBP binding loops; other site 469383014616 ABC-ATPase subunit interface; other site 469383014617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383014618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014619 dimer interface [polypeptide binding]; other site 469383014620 conserved gate region; other site 469383014621 putative PBP binding loops; other site 469383014622 ABC-ATPase subunit interface; other site 469383014623 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383014624 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383014625 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 469383014626 active site 469383014627 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383014628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383014629 DNA-binding site [nucleotide binding]; DNA binding site 469383014630 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 469383014631 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383014632 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383014633 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383014634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383014635 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383014636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383014637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383014638 DNA binding residues [nucleotide binding] 469383014639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383014640 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383014641 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 469383014642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469383014643 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 469383014644 active site 469383014645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469383014646 active site 469383014647 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469383014648 active site 469383014649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383014650 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 469383014651 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 469383014652 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 469383014653 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 469383014654 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 469383014655 classical (c) SDRs; Region: SDR_c; cd05233 469383014656 NAD(P) binding site [chemical binding]; other site 469383014657 active site 469383014658 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 469383014659 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 469383014660 cofactor binding site; other site 469383014661 DNA binding site [nucleotide binding] 469383014662 substrate interaction site [chemical binding]; other site 469383014663 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 469383014664 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 469383014665 classical (c) SDRs; Region: SDR_c; cd05233 469383014666 NAD(P) binding site [chemical binding]; other site 469383014667 active site 469383014668 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383014669 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383014670 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383014671 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383014672 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 469383014673 active site pocket [active] 469383014674 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383014675 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383014676 alpha subunit interface [polypeptide binding]; other site 469383014677 TPP binding site [chemical binding]; other site 469383014678 heterodimer interface [polypeptide binding]; other site 469383014679 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383014680 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 469383014681 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383014682 tetramer interface [polypeptide binding]; other site 469383014683 TPP-binding site [chemical binding]; other site 469383014684 heterodimer interface [polypeptide binding]; other site 469383014685 phosphorylation loop region [posttranslational modification] 469383014686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 469383014687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383014688 active site 469383014689 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 469383014690 CoA-transferase family III; Region: CoA_transf_3; pfam02515 469383014691 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383014692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383014693 DNA-binding site [nucleotide binding]; DNA binding site 469383014694 FCD domain; Region: FCD; pfam07729 469383014695 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 469383014696 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 469383014697 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 469383014698 Strictosidine synthase; Region: Str_synth; pfam03088 469383014699 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383014700 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383014701 alpha subunit interface [polypeptide binding]; other site 469383014702 TPP binding site [chemical binding]; other site 469383014703 heterodimer interface [polypeptide binding]; other site 469383014704 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383014705 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 469383014706 E3 interaction surface; other site 469383014707 lipoyl attachment site [posttranslational modification]; other site 469383014708 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 469383014709 e3 binding domain; Region: E3_binding; pfam02817 469383014710 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383014711 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383014712 tetramer interface [polypeptide binding]; other site 469383014713 TPP-binding site [chemical binding]; other site 469383014714 heterodimer interface [polypeptide binding]; other site 469383014715 phosphorylation loop region [posttranslational modification] 469383014716 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 469383014717 classical (c) SDRs; Region: SDR_c; cd05233 469383014718 NAD(P) binding site [chemical binding]; other site 469383014719 active site 469383014720 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383014721 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 469383014722 NAD(P) binding site [chemical binding]; other site 469383014723 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 469383014724 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 469383014725 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 469383014726 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383014727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014728 Walker A/P-loop; other site 469383014729 ATP binding site [chemical binding]; other site 469383014730 Q-loop/lid; other site 469383014731 ABC transporter signature motif; other site 469383014732 Walker B; other site 469383014733 D-loop; other site 469383014734 H-loop/switch region; other site 469383014735 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014736 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383014737 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014738 Walker A/P-loop; other site 469383014739 ATP binding site [chemical binding]; other site 469383014740 Q-loop/lid; other site 469383014741 ABC transporter signature motif; other site 469383014742 Walker B; other site 469383014743 D-loop; other site 469383014744 H-loop/switch region; other site 469383014745 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014746 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383014747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014748 dimer interface [polypeptide binding]; other site 469383014749 conserved gate region; other site 469383014750 putative PBP binding loops; other site 469383014751 ABC-ATPase subunit interface; other site 469383014752 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383014753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014754 dimer interface [polypeptide binding]; other site 469383014755 conserved gate region; other site 469383014756 ABC-ATPase subunit interface; other site 469383014757 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383014758 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383014759 Right handed beta helix region; Region: Beta_helix; pfam13229 469383014760 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 469383014761 Family description; Region: VCBS; pfam13517 469383014762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383014763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014764 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 469383014765 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 469383014766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383014767 Walker A/P-loop; other site 469383014768 ATP binding site [chemical binding]; other site 469383014769 Q-loop/lid; other site 469383014770 ABC transporter signature motif; other site 469383014771 Walker B; other site 469383014772 D-loop; other site 469383014773 H-loop/switch region; other site 469383014774 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383014775 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383014776 Walker A/P-loop; other site 469383014777 ATP binding site [chemical binding]; other site 469383014778 Q-loop/lid; other site 469383014779 ABC transporter signature motif; other site 469383014780 Walker B; other site 469383014781 D-loop; other site 469383014782 H-loop/switch region; other site 469383014783 TOBE domain; Region: TOBE_2; pfam08402 469383014784 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383014785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014786 dimer interface [polypeptide binding]; other site 469383014787 conserved gate region; other site 469383014788 putative PBP binding loops; other site 469383014789 ABC-ATPase subunit interface; other site 469383014790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 469383014791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014792 putative PBP binding loops; other site 469383014793 ABC-ATPase subunit interface; other site 469383014794 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383014795 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383014796 Right handed beta helix region; Region: Beta_helix; pfam13229 469383014797 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383014798 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 469383014799 catalytic site [active] 469383014800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383014801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 469383014802 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383014803 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 469383014804 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383014805 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383014806 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 469383014807 active site 469383014808 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 469383014809 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 469383014810 metal binding site [ion binding]; metal-binding site 469383014811 substrate binding pocket [chemical binding]; other site 469383014812 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383014813 Creatinine amidohydrolase; Region: Creatininase; pfam02633 469383014814 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383014815 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383014816 homotrimer interaction site [polypeptide binding]; other site 469383014817 putative active site [active] 469383014818 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 469383014819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383014820 active site 469383014821 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383014822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014823 Walker A/P-loop; other site 469383014824 ATP binding site [chemical binding]; other site 469383014825 Q-loop/lid; other site 469383014826 ABC transporter signature motif; other site 469383014827 Walker B; other site 469383014828 D-loop; other site 469383014829 H-loop/switch region; other site 469383014830 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014831 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383014832 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014833 Walker A/P-loop; other site 469383014834 ATP binding site [chemical binding]; other site 469383014835 Q-loop/lid; other site 469383014836 ABC transporter signature motif; other site 469383014837 Walker B; other site 469383014838 D-loop; other site 469383014839 H-loop/switch region; other site 469383014840 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014841 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383014842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014843 dimer interface [polypeptide binding]; other site 469383014844 conserved gate region; other site 469383014845 putative PBP binding loops; other site 469383014846 ABC-ATPase subunit interface; other site 469383014847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383014848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014849 dimer interface [polypeptide binding]; other site 469383014850 conserved gate region; other site 469383014851 putative PBP binding loops; other site 469383014852 ABC-ATPase subunit interface; other site 469383014853 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383014854 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383014855 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383014856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014857 Walker A/P-loop; other site 469383014858 ATP binding site [chemical binding]; other site 469383014859 Q-loop/lid; other site 469383014860 ABC transporter signature motif; other site 469383014861 Walker B; other site 469383014862 D-loop; other site 469383014863 H-loop/switch region; other site 469383014864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014865 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 469383014866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383014867 Walker A/P-loop; other site 469383014868 ATP binding site [chemical binding]; other site 469383014869 Q-loop/lid; other site 469383014870 ABC transporter signature motif; other site 469383014871 Walker B; other site 469383014872 D-loop; other site 469383014873 H-loop/switch region; other site 469383014874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383014875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383014876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383014877 dimer interface [polypeptide binding]; other site 469383014878 conserved gate region; other site 469383014879 putative PBP binding loops; other site 469383014880 ABC-ATPase subunit interface; other site 469383014881 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383014882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 469383014883 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383014884 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383014885 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383014886 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383014887 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383014888 Peptidase family U32; Region: Peptidase_U32; cl03113 469383014889 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 469383014890 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 469383014891 NAD(P) binding site [chemical binding]; other site 469383014892 catalytic residues [active] 469383014893 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383014894 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383014895 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383014896 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 469383014897 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383014898 inhibitor-cofactor binding pocket; inhibition site 469383014899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383014900 catalytic residue [active] 469383014901 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383014902 Sulfatase; Region: Sulfatase; pfam00884 469383014903 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 469383014904 conserved cys residue [active] 469383014905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383014906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383014907 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 469383014908 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 469383014909 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 469383014910 putative molybdopterin cofactor binding site [chemical binding]; other site 469383014911 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 469383014912 putative molybdopterin cofactor binding site; other site 469383014913 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 469383014914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383014915 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383014916 DNA binding residues [nucleotide binding] 469383014917 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383014918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383014919 NAD(P) binding site [chemical binding]; other site 469383014920 TfoX N-terminal domain; Region: TfoX_N; cl17592 469383014921 Uncharacterized conserved protein [Function unknown]; Region: COG5649 469383014922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 469383014923 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383014924 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 469383014925 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383014926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383014927 active site 469383014928 phosphorylation site [posttranslational modification] 469383014929 intermolecular recognition site; other site 469383014930 dimerization interface [polypeptide binding]; other site 469383014931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383014932 DNA binding site [nucleotide binding] 469383014933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383014934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383014935 Mg2+ binding site [ion binding]; other site 469383014936 G-X-G motif; other site 469383014937 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 469383014938 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 469383014939 CGNR zinc finger; Region: zf-CGNR; pfam11706 469383014940 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383014941 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383014942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383014943 MarR family; Region: MarR; pfam01047 469383014944 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 469383014945 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 469383014946 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 469383014947 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 469383014948 YceI-like domain; Region: YceI; smart00867 469383014949 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 469383014950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383014951 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383014952 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 469383014953 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 469383014954 hypothetical protein; Provisional; Region: PRK08204 469383014955 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383014956 active site 469383014957 RibD C-terminal domain; Region: RibD_C; cl17279 469383014958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383014959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014960 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383014961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383014962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383014963 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383014964 NAD(P) binding site [chemical binding]; other site 469383014965 active site 469383014966 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 469383014967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383014968 SCP-2 sterol transfer family; Region: SCP2; pfam02036 469383014969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383014970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383014971 active site 469383014972 phosphorylation site [posttranslational modification] 469383014973 intermolecular recognition site; other site 469383014974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383014975 DNA binding residues [nucleotide binding] 469383014976 dimerization interface [polypeptide binding]; other site 469383014977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383014978 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 469383014979 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383014980 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383014981 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 469383014982 cleavage site 469383014983 active site 469383014984 substrate binding sites [chemical binding]; other site 469383014985 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 469383014986 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 469383014987 Beta-lactamase; Region: Beta-lactamase; pfam00144 469383014988 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 469383014989 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 469383014990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383014991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383014992 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 469383014993 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 469383014994 active site 469383014995 catalytic tetrad [active] 469383014996 RibD C-terminal domain; Region: RibD_C; cl17279 469383014997 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 469383014998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 469383014999 Protein kinase domain; Region: Pkinase; pfam00069 469383015000 Catalytic domain of Protein Kinases; Region: PKc; cd00180 469383015001 active site 469383015002 ATP binding site [chemical binding]; other site 469383015003 substrate binding site [chemical binding]; other site 469383015004 activation loop (A-loop); other site 469383015005 PIN domain; Region: PIN_3; cl17397 469383015006 EthD domain; Region: EthD; cl17553 469383015007 PIN domain; Region: PIN_3; cl17397 469383015008 Helix-turn-helix domain; Region: HTH_19; pfam12844 469383015009 non-specific DNA binding site [nucleotide binding]; other site 469383015010 salt bridge; other site 469383015011 sequence-specific DNA binding site [nucleotide binding]; other site 469383015012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383015013 non-specific DNA binding site [nucleotide binding]; other site 469383015014 salt bridge; other site 469383015015 sequence-specific DNA binding site [nucleotide binding]; other site 469383015016 Replication-relaxation; Region: Replic_Relax; pfam13814 469383015017 HEAT repeats; Region: HEAT_2; pfam13646 469383015018 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 469383015019 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 469383015020 catalytic residues [active] 469383015021 catalytic nucleophile [active] 469383015022 Recombinase; Region: Recombinase; pfam07508 469383015023 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 469383015024 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 469383015025 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 469383015026 dimerization interface [polypeptide binding]; other site 469383015027 ligand binding site [chemical binding]; other site 469383015028 NADP binding site [chemical binding]; other site 469383015029 catalytic site [active] 469383015030 exopolyphosphatase; Region: exo_poly_only; TIGR03706 469383015031 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 469383015032 hypothetical protein; Provisional; Region: PRK05858 469383015033 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383015034 PYR/PP interface [polypeptide binding]; other site 469383015035 dimer interface [polypeptide binding]; other site 469383015036 TPP binding site [chemical binding]; other site 469383015037 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383015038 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 469383015039 TPP-binding site; other site 469383015040 dimer interface [polypeptide binding]; other site 469383015041 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 469383015042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383015043 dimerization interface [polypeptide binding]; other site 469383015044 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 469383015045 cyclase homology domain; Region: CHD; cd07302 469383015046 nucleotidyl binding site; other site 469383015047 metal binding site [ion binding]; metal-binding site 469383015048 dimer interface [polypeptide binding]; other site 469383015049 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 469383015050 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 469383015051 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383015052 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 469383015053 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 469383015054 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 469383015055 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 469383015056 TPP binding site [chemical binding]; other site 469383015057 alpha subunit interface [polypeptide binding]; other site 469383015058 heterodimer interface [polypeptide binding]; other site 469383015059 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 469383015060 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 469383015061 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 469383015062 tetramer interface [polypeptide binding]; other site 469383015063 TPP-binding site [chemical binding]; other site 469383015064 heterodimer interface [polypeptide binding]; other site 469383015065 phosphorylation loop region [posttranslational modification] 469383015066 AAA ATPase domain; Region: AAA_16; pfam13191 469383015067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383015068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383015069 DNA binding residues [nucleotide binding] 469383015070 dimerization interface [polypeptide binding]; other site 469383015071 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 469383015072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383015073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383015074 DNA binding residues [nucleotide binding] 469383015075 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 469383015076 dinuclear metal binding motif [ion binding]; other site 469383015077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015078 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015079 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383015080 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015081 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383015082 AsnC family; Region: AsnC_trans_reg; pfam01037 469383015083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 469383015084 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 469383015085 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 469383015086 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 469383015087 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 469383015088 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 469383015089 Catalytic site; other site 469383015090 Staphylococcal nuclease homologue; Region: SNase; pfam00565 469383015091 carbon storage regulator; Provisional; Region: PRK01712 469383015092 Septum formation initiator; Region: DivIC; pfam04977 469383015093 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 469383015094 enolase; Provisional; Region: eno; PRK00077 469383015095 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 469383015096 dimer interface [polypeptide binding]; other site 469383015097 metal binding site [ion binding]; metal-binding site 469383015098 substrate binding pocket [chemical binding]; other site 469383015099 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 469383015100 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 469383015101 homodimer interface [polypeptide binding]; other site 469383015102 metal binding site [ion binding]; metal-binding site 469383015103 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 469383015104 homodimer interface [polypeptide binding]; other site 469383015105 active site 469383015106 putative chemical substrate binding site [chemical binding]; other site 469383015107 metal binding site [ion binding]; metal-binding site 469383015108 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 469383015109 SurA N-terminal domain; Region: SurA_N_3; cl07813 469383015110 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 469383015111 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 469383015112 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 469383015113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383015114 ATP binding site [chemical binding]; other site 469383015115 putative Mg++ binding site [ion binding]; other site 469383015116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383015117 nucleotide binding region [chemical binding]; other site 469383015118 ATP-binding site [chemical binding]; other site 469383015119 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 469383015120 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 469383015121 putative active site [active] 469383015122 catalytic residue [active] 469383015123 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 469383015124 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 469383015125 5S rRNA interface [nucleotide binding]; other site 469383015126 CTC domain interface [polypeptide binding]; other site 469383015127 L16 interface [polypeptide binding]; other site 469383015128 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 469383015129 beta-D-glucuronidase; Provisional; Region: PRK10150 469383015130 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 469383015131 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 469383015132 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 469383015133 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 469383015134 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 469383015135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469383015136 active site 469383015137 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 469383015138 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 469383015139 Substrate binding site; other site 469383015140 Mg++ binding site; other site 469383015141 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 469383015142 active site 469383015143 substrate binding site [chemical binding]; other site 469383015144 CoA binding site [chemical binding]; other site 469383015145 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 469383015146 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383015147 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 469383015148 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 469383015149 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614 469383015150 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 469383015151 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 469383015152 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 469383015153 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 469383015154 active site 469383015155 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 469383015156 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 469383015157 active site 469383015158 HIGH motif; other site 469383015159 KMSKS motif; other site 469383015160 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 469383015161 tRNA binding surface [nucleotide binding]; other site 469383015162 anticodon binding site; other site 469383015163 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 469383015164 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 469383015165 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 469383015166 L-aspartate oxidase; Provisional; Region: PRK06175 469383015167 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 469383015168 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 469383015169 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 469383015170 putative Iron-sulfur protein interface [polypeptide binding]; other site 469383015171 proximal heme binding site [chemical binding]; other site 469383015172 distal heme binding site [chemical binding]; other site 469383015173 putative dimer interface [polypeptide binding]; other site 469383015174 Predicted methyltransferases [General function prediction only]; Region: COG0313 469383015175 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 469383015176 putative SAM binding site [chemical binding]; other site 469383015177 putative homodimer interface [polypeptide binding]; other site 469383015178 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383015179 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 469383015180 nucleotide binding site [chemical binding]; other site 469383015181 Transcriptional regulator [Transcription]; Region: LytR; COG1316 469383015182 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 469383015183 glycyl-tRNA synthetase; Provisional; Region: PRK04173 469383015184 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 469383015185 dimer interface [polypeptide binding]; other site 469383015186 motif 1; other site 469383015187 active site 469383015188 motif 2; other site 469383015189 motif 3; other site 469383015190 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 469383015191 anticodon binding site; other site 469383015192 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 469383015193 dinuclear metal binding motif [ion binding]; other site 469383015194 SCP-2 sterol transfer family; Region: SCP2; pfam02036 469383015195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383015196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383015197 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 469383015198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383015199 Walker A motif; other site 469383015200 ATP binding site [chemical binding]; other site 469383015201 Walker B motif; other site 469383015202 arginine finger; other site 469383015203 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 469383015204 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 469383015205 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 469383015206 putative dimer interface [polypeptide binding]; other site 469383015207 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 469383015208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383015209 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 469383015210 NAD(P) binding site [chemical binding]; other site 469383015211 active site 469383015212 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 469383015213 hydrophobic ligand binding site; other site 469383015214 MarR family; Region: MarR_2; cl17246 469383015215 malate dehydrogenase; Provisional; Region: PRK05442 469383015216 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 469383015217 NAD(P) binding site [chemical binding]; other site 469383015218 dimer interface [polypeptide binding]; other site 469383015219 malate binding site [chemical binding]; other site 469383015220 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 469383015221 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 469383015222 active site 469383015223 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 469383015224 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 469383015225 active site 469383015226 Zn binding site [ion binding]; other site 469383015227 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 469383015228 Peptidase family M50; Region: Peptidase_M50; pfam02163 469383015229 active site 469383015230 putative substrate binding region [chemical binding]; other site 469383015231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 469383015232 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 469383015233 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 469383015234 L-aspartate oxidase; Provisional; Region: PRK06175 469383015235 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 469383015236 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 469383015237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383015238 catalytic loop [active] 469383015239 iron binding site [ion binding]; other site 469383015240 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 469383015241 Cysteine-rich domain; Region: CCG; pfam02754 469383015242 Cysteine-rich domain; Region: CCG; pfam02754 469383015243 transcriptional regulator NarP; Provisional; Region: PRK10403 469383015244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383015245 DNA binding residues [nucleotide binding] 469383015246 dimerization interface [polypeptide binding]; other site 469383015247 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 469383015248 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 469383015249 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 469383015250 aspartate kinase; Reviewed; Region: PRK06635 469383015251 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 469383015252 putative nucleotide binding site [chemical binding]; other site 469383015253 putative catalytic residues [active] 469383015254 putative Mg ion binding site [ion binding]; other site 469383015255 putative aspartate binding site [chemical binding]; other site 469383015256 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 469383015257 putative allosteric regulatory site; other site 469383015258 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 469383015259 putative allosteric regulatory residue; other site 469383015260 recombination protein RecR; Reviewed; Region: recR; PRK00076 469383015261 RecR protein; Region: RecR; pfam02132 469383015262 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 469383015263 putative active site [active] 469383015264 putative metal-binding site [ion binding]; other site 469383015265 tetramer interface [polypeptide binding]; other site 469383015266 hypothetical protein; Validated; Region: PRK00153 469383015267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383015268 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 469383015269 Walker A motif; other site 469383015270 ATP binding site [chemical binding]; other site 469383015271 Walker B motif; other site 469383015272 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 469383015273 arginine finger; other site 469383015274 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383015275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383015276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383015277 DNA binding residues [nucleotide binding] 469383015278 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 469383015279 Bacterial sugar transferase; Region: Bac_transf; pfam02397 469383015280 O-Antigen ligase; Region: Wzy_C; pfam04932 469383015281 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 469383015282 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 469383015283 active site 469383015284 dimer interface [polypeptide binding]; other site 469383015285 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 469383015286 Ligand Binding Site [chemical binding]; other site 469383015287 Molecular Tunnel; other site 469383015288 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 469383015289 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 469383015290 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 469383015291 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383015292 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 469383015293 putative active site [active] 469383015294 putative metal binding site [ion binding]; other site 469383015295 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383015296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015297 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 469383015298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469383015299 active site 469383015300 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 469383015301 Chain length determinant protein; Region: Wzz; pfam02706 469383015302 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 469383015303 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383015304 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 469383015305 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 469383015306 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015308 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 469383015309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015311 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 469383015312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 469383015313 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 469383015314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 469383015315 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 469383015316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 469383015317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383015318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383015319 NAD(P) binding site [chemical binding]; other site 469383015320 active site 469383015321 NAD synthetase; Reviewed; Region: nadE; PRK00876 469383015322 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 469383015323 Ligand Binding Site [chemical binding]; other site 469383015324 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 469383015325 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 469383015326 active site 469383015327 dimer interface [polypeptide binding]; other site 469383015328 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 469383015329 Ligand Binding Site [chemical binding]; other site 469383015330 Molecular Tunnel; other site 469383015331 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 469383015332 AMP-binding enzyme; Region: AMP-binding; pfam00501 469383015333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383015334 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 469383015335 acyl-activating enzyme (AAE) consensus motif; other site 469383015336 acyl-activating enzyme (AAE) consensus motif; other site 469383015337 AMP binding site [chemical binding]; other site 469383015338 active site 469383015339 CoA binding site [chemical binding]; other site 469383015340 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 469383015341 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 469383015342 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 469383015343 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 469383015344 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 469383015345 Protein of unknown function, DUF480; Region: DUF480; pfam04337 469383015346 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 469383015347 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 469383015348 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 469383015349 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469383015350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 469383015351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383015352 metal binding site [ion binding]; metal-binding site 469383015353 active site 469383015354 I-site; other site 469383015355 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 469383015356 AAA ATPase domain; Region: AAA_16; pfam13191 469383015357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 469383015358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383015359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383015360 DNA binding residues [nucleotide binding] 469383015361 dimerization interface [polypeptide binding]; other site 469383015362 Methyltransferase domain; Region: Methyltransf_11; pfam08241 469383015363 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383015364 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015365 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 469383015366 Haemolysin-III related; Region: HlyIII; pfam03006 469383015367 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 469383015368 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 469383015369 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 469383015370 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 469383015371 TM-ABC transporter signature motif; other site 469383015372 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 469383015373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383015374 Walker A/P-loop; other site 469383015375 ATP binding site [chemical binding]; other site 469383015376 Q-loop/lid; other site 469383015377 ABC transporter signature motif; other site 469383015378 Walker B; other site 469383015379 D-loop; other site 469383015380 H-loop/switch region; other site 469383015381 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 469383015382 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 469383015383 putative ligand binding site [chemical binding]; other site 469383015384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383015385 dimerization interface [polypeptide binding]; other site 469383015386 putative DNA binding site [nucleotide binding]; other site 469383015387 putative Zn2+ binding site [ion binding]; other site 469383015388 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383015389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 469383015390 nucleotide binding site [chemical binding]; other site 469383015391 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 469383015392 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 469383015393 nucleoside/Zn binding site; other site 469383015394 dimer interface [polypeptide binding]; other site 469383015395 catalytic motif [active] 469383015396 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 469383015397 active site 469383015398 catalytic residues [active] 469383015399 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 469383015400 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 469383015401 Ligand Binding Site [chemical binding]; other site 469383015402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383015403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383015404 Predicted flavoprotein [General function prediction only]; Region: COG0431 469383015405 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 469383015406 YceI-like domain; Region: YceI; smart00867 469383015407 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 469383015408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383015409 active site 469383015410 phosphorylation site [posttranslational modification] 469383015411 intermolecular recognition site; other site 469383015412 dimerization interface [polypeptide binding]; other site 469383015413 CHASE3 domain; Region: CHASE3; pfam05227 469383015414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383015415 dimer interface [polypeptide binding]; other site 469383015416 phosphorylation site [posttranslational modification] 469383015417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383015418 ATP binding site [chemical binding]; other site 469383015419 Mg2+ binding site [ion binding]; other site 469383015420 G-X-G motif; other site 469383015421 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 469383015422 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383015423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383015424 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 469383015425 active site 469383015426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383015427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383015428 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 469383015429 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 469383015430 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 469383015431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383015432 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 469383015433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383015434 DNA binding residues [nucleotide binding] 469383015435 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 469383015436 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 469383015437 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 469383015438 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383015439 Walker A/P-loop; other site 469383015440 ATP binding site [chemical binding]; other site 469383015441 Q-loop/lid; other site 469383015442 ABC transporter signature motif; other site 469383015443 Walker B; other site 469383015444 D-loop; other site 469383015445 H-loop/switch region; other site 469383015446 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383015447 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383015448 Fic/DOC family; Region: Fic; cl00960 469383015449 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 469383015450 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 469383015451 putative NAD(P) binding site [chemical binding]; other site 469383015452 putative substrate binding site [chemical binding]; other site 469383015453 catalytic Zn binding site [ion binding]; other site 469383015454 structural Zn binding site [ion binding]; other site 469383015455 Clp protease; Region: CLP_protease; pfam00574 469383015456 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 469383015457 oligomer interface [polypeptide binding]; other site 469383015458 active site residues [active] 469383015459 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 469383015460 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 469383015461 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 469383015462 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 469383015463 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 469383015464 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 469383015465 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 469383015466 active site residue [active] 469383015467 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 469383015468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383015469 dimerization interface [polypeptide binding]; other site 469383015470 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 469383015471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383015472 dimer interface [polypeptide binding]; other site 469383015473 phosphorylation site [posttranslational modification] 469383015474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383015475 ATP binding site [chemical binding]; other site 469383015476 Mg2+ binding site [ion binding]; other site 469383015477 G-X-G motif; other site 469383015478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383015479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383015480 active site 469383015481 phosphorylation site [posttranslational modification] 469383015482 intermolecular recognition site; other site 469383015483 dimerization interface [polypeptide binding]; other site 469383015484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383015485 DNA binding site [nucleotide binding] 469383015486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 469383015487 active site 469383015488 phosphorylation site [posttranslational modification] 469383015489 intermolecular recognition site; other site 469383015490 dimerization interface [polypeptide binding]; other site 469383015491 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 469383015492 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 469383015493 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 469383015494 Domain of unknown function (DUF389); Region: DUF389; cl00781 469383015495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383015496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383015497 ATP binding site [chemical binding]; other site 469383015498 Mg2+ binding site [ion binding]; other site 469383015499 G-X-G motif; other site 469383015500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383015501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383015502 active site 469383015503 phosphorylation site [posttranslational modification] 469383015504 intermolecular recognition site; other site 469383015505 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383015506 DNA binding residues [nucleotide binding] 469383015507 dimerization interface [polypeptide binding]; other site 469383015508 heat shock protein HtpX; Provisional; Region: PRK02391 469383015509 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 469383015510 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 469383015511 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 469383015512 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383015513 Walker A/P-loop; other site 469383015514 ATP binding site [chemical binding]; other site 469383015515 Q-loop/lid; other site 469383015516 ABC transporter signature motif; other site 469383015517 Walker B; other site 469383015518 D-loop; other site 469383015519 H-loop/switch region; other site 469383015520 Predicted transcriptional regulators [Transcription]; Region: COG1510 469383015521 MarR family; Region: MarR_2; cl17246 469383015522 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 469383015523 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 469383015524 FeS assembly protein SufD; Region: sufD; TIGR01981 469383015525 FeS assembly protein SufB; Region: sufB; TIGR01980 469383015526 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 469383015527 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 469383015528 [2Fe-2S] cluster binding site [ion binding]; other site 469383015529 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 469383015530 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 469383015531 trimerization site [polypeptide binding]; other site 469383015532 active site 469383015533 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 469383015534 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 469383015535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383015536 catalytic residue [active] 469383015537 FeS assembly ATPase SufC; Region: sufC; TIGR01978 469383015538 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 469383015539 Walker A/P-loop; other site 469383015540 ATP binding site [chemical binding]; other site 469383015541 Q-loop/lid; other site 469383015542 ABC transporter signature motif; other site 469383015543 Walker B; other site 469383015544 D-loop; other site 469383015545 H-loop/switch region; other site 469383015546 Rrf2 family protein; Region: rrf2_super; TIGR00738 469383015547 Transcriptional regulator; Region: Rrf2; pfam02082 469383015548 ribonuclease D; Region: rnd; TIGR01388 469383015549 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 469383015550 catalytic site [active] 469383015551 putative active site [active] 469383015552 putative substrate binding site [chemical binding]; other site 469383015553 HRDC domain; Region: HRDC; pfam00570 469383015554 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 469383015555 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 469383015556 NodB motif; other site 469383015557 active site 469383015558 catalytic site [active] 469383015559 metal binding site [ion binding]; metal-binding site 469383015560 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383015561 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 469383015562 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 469383015563 Transcriptional regulator [Transcription]; Region: IclR; COG1414 469383015564 Bacterial transcriptional regulator; Region: IclR; pfam01614 469383015565 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 469383015566 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 469383015567 inhibitor-cofactor binding pocket; inhibition site 469383015568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383015569 catalytic residue [active] 469383015570 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 469383015571 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 469383015572 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 469383015573 putative dimer interface [polypeptide binding]; other site 469383015574 N-terminal domain interface [polypeptide binding]; other site 469383015575 putative substrate binding pocket (H-site) [chemical binding]; other site 469383015576 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 469383015577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383015578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383015579 AAA domain; Region: AAA_30; pfam13604 469383015580 Family description; Region: UvrD_C_2; pfam13538 469383015581 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 469383015582 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 469383015583 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 469383015584 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 469383015585 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 469383015586 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 469383015587 FAD binding domain; Region: FAD_binding_4; pfam01565 469383015588 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 469383015589 DNA polymerase III subunit delta'; Validated; Region: PRK08485 469383015590 short chain dehydrogenase; Provisional; Region: PRK05872 469383015591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383015592 NAD(P) binding site [chemical binding]; other site 469383015593 active site 469383015594 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 469383015595 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 469383015596 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 469383015597 ligand binding site [chemical binding]; other site 469383015598 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383015599 Ferritin-like domain; Region: Ferritin_2; pfam13668 469383015600 Ferritin-like domain; Region: Ferritin_2; pfam13668 469383015601 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 469383015602 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 469383015603 NAD binding site [chemical binding]; other site 469383015604 homodimer interface [polypeptide binding]; other site 469383015605 active site 469383015606 substrate binding site [chemical binding]; other site 469383015607 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 469383015608 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 469383015609 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 469383015610 active site 469383015611 dimer interface [polypeptide binding]; other site 469383015612 effector binding site; other site 469383015613 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 469383015614 TSCPD domain; Region: TSCPD; pfam12637 469383015615 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 469383015616 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 469383015617 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 469383015618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383015619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383015620 DNA binding residues [nucleotide binding] 469383015621 methionine sulfoxide reductase B; Provisional; Region: PRK00222 469383015622 SelR domain; Region: SelR; pfam01641 469383015623 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 469383015624 MarR family; Region: MarR; pfam01047 469383015625 H+ Antiporter protein; Region: 2A0121; TIGR00900 469383015626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383015627 putative substrate translocation pore; other site 469383015628 Cupin domain; Region: Cupin_2; cl17218 469383015629 FtsH Extracellular; Region: FtsH_ext; pfam06480 469383015630 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 469383015631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383015632 Walker A motif; other site 469383015633 ATP binding site [chemical binding]; other site 469383015634 Walker B motif; other site 469383015635 arginine finger; other site 469383015636 Peptidase family M41; Region: Peptidase_M41; pfam01434 469383015637 RDD family; Region: RDD; pfam06271 469383015638 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 469383015639 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469383015640 dimer interface [polypeptide binding]; other site 469383015641 active site 469383015642 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 469383015643 dimer interface [polypeptide binding]; other site 469383015644 active site 469383015645 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383015646 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383015647 Walker A/P-loop; other site 469383015648 ATP binding site [chemical binding]; other site 469383015649 Q-loop/lid; other site 469383015650 ABC transporter signature motif; other site 469383015651 Walker B; other site 469383015652 D-loop; other site 469383015653 H-loop/switch region; other site 469383015654 TOBE domain; Region: TOBE; cl01440 469383015655 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383015656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383015657 dimer interface [polypeptide binding]; other site 469383015658 conserved gate region; other site 469383015659 putative PBP binding loops; other site 469383015660 ABC-ATPase subunit interface; other site 469383015661 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 469383015662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383015663 ABC-ATPase subunit interface; other site 469383015664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383015665 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 469383015666 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383015667 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 469383015668 substrate binding site [chemical binding]; other site 469383015669 ATP binding site [chemical binding]; other site 469383015670 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 469383015671 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 469383015672 NAD binding site [chemical binding]; other site 469383015673 sugar binding site [chemical binding]; other site 469383015674 divalent metal binding site [ion binding]; other site 469383015675 tetramer (dimer of dimers) interface [polypeptide binding]; other site 469383015676 dimer interface [polypeptide binding]; other site 469383015677 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 469383015678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383015679 DNA-binding site [nucleotide binding]; DNA binding site 469383015680 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 469383015681 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 469383015682 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 469383015683 putative ligand binding site [chemical binding]; other site 469383015684 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 469383015685 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383015686 PYR/PP interface [polypeptide binding]; other site 469383015687 dimer interface [polypeptide binding]; other site 469383015688 TPP binding site [chemical binding]; other site 469383015689 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 469383015690 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383015691 TPP-binding site [chemical binding]; other site 469383015692 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 469383015693 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 469383015694 NAD(P) binding site [chemical binding]; other site 469383015695 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 469383015696 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383015697 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 469383015698 substrate binding site [chemical binding]; other site 469383015699 ATP binding site [chemical binding]; other site 469383015700 KduI/IolB family; Region: KduI; pfam04962 469383015701 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 469383015702 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 469383015703 tetrameric interface [polypeptide binding]; other site 469383015704 NAD binding site [chemical binding]; other site 469383015705 catalytic residues [active] 469383015706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383015707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383015708 dimer interface [polypeptide binding]; other site 469383015709 phosphorylation site [posttranslational modification] 469383015710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383015711 ATP binding site [chemical binding]; other site 469383015712 Mg2+ binding site [ion binding]; other site 469383015713 G-X-G motif; other site 469383015714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383015715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383015716 active site 469383015717 phosphorylation site [posttranslational modification] 469383015718 intermolecular recognition site; other site 469383015719 dimerization interface [polypeptide binding]; other site 469383015720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383015721 DNA binding site [nucleotide binding] 469383015722 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383015723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383015724 S-adenosylmethionine binding site [chemical binding]; other site 469383015725 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383015726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383015727 S-adenosylmethionine binding site [chemical binding]; other site 469383015728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015729 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383015730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469383015731 active site 469383015732 Methyltransferase domain; Region: Methyltransf_24; pfam13578 469383015733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383015734 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383015735 NAD(P) binding site [chemical binding]; other site 469383015736 active site 469383015737 GtrA-like protein; Region: GtrA; pfam04138 469383015738 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383015739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383015740 S-adenosylmethionine binding site [chemical binding]; other site 469383015741 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 469383015742 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 469383015743 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 469383015744 Substrate binding site; other site 469383015745 Mg++ binding site; other site 469383015746 metal-binding site 469383015747 Mg++ binding site; other site 469383015748 metal-binding site 469383015749 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 469383015750 Ligand binding site; other site 469383015751 Putative Catalytic site; other site 469383015752 DXD motif; other site 469383015753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 469383015754 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 469383015755 dimer interface [polypeptide binding]; other site 469383015756 active site 469383015757 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383015758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383015759 NAD(P) binding site [chemical binding]; other site 469383015760 active site 469383015761 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 469383015762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383015763 active site 469383015764 motif I; other site 469383015765 motif II; other site 469383015766 putative translaldolase; Provisional; Region: PRK12376 469383015767 catalytic residue [active] 469383015768 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383015769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383015770 S-adenosylmethionine binding site [chemical binding]; other site 469383015771 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 469383015772 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 469383015773 Interdomain contacts; other site 469383015774 Cytokine receptor motif; other site 469383015775 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 469383015776 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 469383015777 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 469383015778 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 469383015779 Walker A/P-loop; other site 469383015780 ATP binding site [chemical binding]; other site 469383015781 Q-loop/lid; other site 469383015782 ABC transporter signature motif; other site 469383015783 Walker B; other site 469383015784 D-loop; other site 469383015785 H-loop/switch region; other site 469383015786 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 469383015787 putative carbohydrate binding site [chemical binding]; other site 469383015788 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 469383015789 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 469383015790 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 469383015791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015792 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015793 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015794 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 469383015795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469383015796 active site 469383015797 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383015798 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015799 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015800 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015801 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015802 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015803 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015805 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 469383015806 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 469383015807 Ligand binding site; other site 469383015808 Putative Catalytic site; other site 469383015809 DXD motif; other site 469383015810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015811 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383015812 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 469383015813 putative trimer interface [polypeptide binding]; other site 469383015814 putative CoA binding site [chemical binding]; other site 469383015815 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 469383015816 putative trimer interface [polypeptide binding]; other site 469383015817 putative CoA binding site [chemical binding]; other site 469383015818 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 469383015819 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 469383015820 inhibitor-cofactor binding pocket; inhibition site 469383015821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383015822 catalytic residue [active] 469383015823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 469383015824 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 469383015825 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 469383015826 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 469383015827 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 469383015828 NADP-binding site; other site 469383015829 homotetramer interface [polypeptide binding]; other site 469383015830 substrate binding site [chemical binding]; other site 469383015831 homodimer interface [polypeptide binding]; other site 469383015832 active site 469383015833 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 469383015834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015835 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 469383015836 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 469383015837 NADP-binding site; other site 469383015838 homotetramer interface [polypeptide binding]; other site 469383015839 substrate binding site [chemical binding]; other site 469383015840 homodimer interface [polypeptide binding]; other site 469383015841 active site 469383015842 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 469383015843 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 469383015844 Methyltransferase domain; Region: Methyltransf_31; pfam13847 469383015845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383015846 S-adenosylmethionine binding site [chemical binding]; other site 469383015847 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 469383015848 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 469383015849 active site 469383015850 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 469383015851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015852 Methyltransferase domain; Region: Methyltransf_23; pfam13489 469383015853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383015854 S-adenosylmethionine binding site [chemical binding]; other site 469383015855 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 469383015856 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 469383015857 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 469383015858 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 469383015859 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 469383015860 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 469383015861 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 469383015862 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 469383015863 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 469383015864 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383015865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383015866 NAD(P) binding site [chemical binding]; other site 469383015867 active site 469383015868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 469383015869 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 469383015870 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383015871 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 469383015872 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 469383015873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383015874 S-adenosylmethionine binding site [chemical binding]; other site 469383015875 CHASE3 domain; Region: CHASE3; pfam05227 469383015876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383015877 dimerization interface [polypeptide binding]; other site 469383015878 GAF domain; Region: GAF_3; pfam13492 469383015879 PAS domain S-box; Region: sensory_box; TIGR00229 469383015880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 469383015881 putative active site [active] 469383015882 heme pocket [chemical binding]; other site 469383015883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383015884 dimer interface [polypeptide binding]; other site 469383015885 phosphorylation site [posttranslational modification] 469383015886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383015887 ATP binding site [chemical binding]; other site 469383015888 Mg2+ binding site [ion binding]; other site 469383015889 G-X-G motif; other site 469383015890 Response regulator receiver domain; Region: Response_reg; pfam00072 469383015891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383015892 active site 469383015893 phosphorylation site [posttranslational modification] 469383015894 intermolecular recognition site; other site 469383015895 dimerization interface [polypeptide binding]; other site 469383015896 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 469383015897 Bacterial sugar transferase; Region: Bac_transf; pfam02397 469383015898 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 469383015899 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 469383015900 NAD binding site [chemical binding]; other site 469383015901 putative substrate binding site 2 [chemical binding]; other site 469383015902 putative substrate binding site 1 [chemical binding]; other site 469383015903 active site 469383015904 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 469383015905 Ferritin-like domain; Region: Ferritin; pfam00210 469383015906 ferroxidase diiron center [ion binding]; other site 469383015907 Putative transcription activator [Transcription]; Region: TenA; COG0819 469383015908 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 469383015909 MoaE interaction surface [polypeptide binding]; other site 469383015910 MoeB interaction surface [polypeptide binding]; other site 469383015911 thiocarboxylated glycine; other site 469383015912 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 469383015913 MoaE homodimer interface [polypeptide binding]; other site 469383015914 MoaD interaction [polypeptide binding]; other site 469383015915 active site residues [active] 469383015916 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 469383015917 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383015918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383015919 Walker A/P-loop; other site 469383015920 ATP binding site [chemical binding]; other site 469383015921 Q-loop/lid; other site 469383015922 ABC transporter signature motif; other site 469383015923 Walker B; other site 469383015924 D-loop; other site 469383015925 H-loop/switch region; other site 469383015926 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 469383015927 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 469383015928 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 469383015929 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 469383015930 active site 469383015931 oxyanion hole [active] 469383015932 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 469383015933 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 469383015934 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 469383015935 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 469383015936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383015937 motif II; other site 469383015938 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 469383015939 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 469383015940 Active Sites [active] 469383015941 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 469383015942 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 469383015943 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 469383015944 Active Sites [active] 469383015945 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 469383015946 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 469383015947 CysD dimerization site [polypeptide binding]; other site 469383015948 G1 box; other site 469383015949 putative GEF interaction site [polypeptide binding]; other site 469383015950 GTP/Mg2+ binding site [chemical binding]; other site 469383015951 Switch I region; other site 469383015952 G2 box; other site 469383015953 G3 box; other site 469383015954 Switch II region; other site 469383015955 G4 box; other site 469383015956 G5 box; other site 469383015957 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 469383015958 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 469383015959 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 469383015960 active site 469383015961 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 469383015962 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 469383015963 ATP-grasp domain; Region: ATP-grasp_4; cl17255 469383015964 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 469383015965 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 469383015966 carboxyltransferase (CT) interaction site; other site 469383015967 biotinylation site [posttranslational modification]; other site 469383015968 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 469383015969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 469383015970 Coenzyme A binding pocket [chemical binding]; other site 469383015971 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 469383015972 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 469383015973 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 469383015974 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 469383015975 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 469383015976 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 469383015977 CoA-ligase; Region: Ligase_CoA; pfam00549 469383015978 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 469383015979 CoA binding domain; Region: CoA_binding; pfam02629 469383015980 CoA-ligase; Region: Ligase_CoA; pfam00549 469383015981 aspartate aminotransferase; Provisional; Region: PRK05764 469383015982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383015983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383015984 homodimer interface [polypeptide binding]; other site 469383015985 catalytic residue [active] 469383015986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 469383015987 metal binding site [ion binding]; metal-binding site 469383015988 active site 469383015989 I-site; other site 469383015990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 469383015991 Heme NO binding; Region: HNOB; pfam07700 469383015992 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 469383015993 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 469383015994 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 469383015995 FeoA domain; Region: FeoA; pfam04023 469383015996 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 469383015997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383015998 NAD(P) binding site [chemical binding]; other site 469383015999 active site 469383016000 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 469383016001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383016002 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383016003 DNA binding residues [nucleotide binding] 469383016004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 469383016005 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 469383016006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383016007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469383016008 dimerization interface [polypeptide binding]; other site 469383016009 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 469383016010 EamA-like transporter family; Region: EamA; pfam00892 469383016011 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 469383016012 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 469383016013 active site 469383016014 DNA binding site [nucleotide binding] 469383016015 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 469383016016 DNA binding site [nucleotide binding] 469383016017 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 469383016018 Lamin Tail Domain; Region: LTD; pfam00932 469383016019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016020 putative substrate translocation pore; other site 469383016021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016022 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383016023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383016024 active site 469383016025 phosphorylation site [posttranslational modification] 469383016026 intermolecular recognition site; other site 469383016027 dimerization interface [polypeptide binding]; other site 469383016028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383016029 DNA binding residues [nucleotide binding] 469383016030 dimerization interface [polypeptide binding]; other site 469383016031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383016032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 469383016033 ATP binding site [chemical binding]; other site 469383016034 Mg2+ binding site [ion binding]; other site 469383016035 G-X-G motif; other site 469383016036 PspC domain; Region: PspC; pfam04024 469383016037 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 469383016038 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 469383016039 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 469383016040 Catalytic site [active] 469383016041 Glycerate kinase family; Region: Gly_kinase; cl00841 469383016042 Glycerate kinase family; Region: Gly_kinase; cl00841 469383016043 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 469383016044 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 469383016045 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 469383016046 phosphoglycolate phosphatase; Provisional; Region: PRK01158 469383016047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 469383016048 active site 469383016049 motif I; other site 469383016050 motif II; other site 469383016051 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 469383016052 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383016053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383016054 catalytic residue [active] 469383016055 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 469383016056 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 469383016057 AsnC family; Region: AsnC_trans_reg; pfam01037 469383016058 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 469383016059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383016060 ATP binding site [chemical binding]; other site 469383016061 putative Mg++ binding site [ion binding]; other site 469383016062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383016063 nucleotide binding region [chemical binding]; other site 469383016064 ATP-binding site [chemical binding]; other site 469383016065 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 469383016066 Peptidase family M23; Region: Peptidase_M23; pfam01551 469383016067 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 469383016068 Sodium Bile acid symporter family; Region: SBF; cl17470 469383016069 Rhomboid family; Region: Rhomboid; pfam01694 469383016070 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 469383016071 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 469383016072 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 469383016073 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 469383016074 tetracycline repressor protein TetR; Provisional; Region: PRK13756 469383016075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016076 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 469383016077 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 469383016078 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383016079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383016080 putative DNA binding site [nucleotide binding]; other site 469383016081 putative Zn2+ binding site [ion binding]; other site 469383016082 AsnC family; Region: AsnC_trans_reg; pfam01037 469383016083 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 469383016084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383016085 non-specific DNA binding site [nucleotide binding]; other site 469383016086 salt bridge; other site 469383016087 sequence-specific DNA binding site [nucleotide binding]; other site 469383016088 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383016089 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 469383016090 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 469383016091 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 469383016092 AAA ATPase domain; Region: AAA_16; pfam13191 469383016093 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383016094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383016095 DNA binding residues [nucleotide binding] 469383016096 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 469383016097 Cytochrome P450; Region: p450; cl12078 469383016098 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 469383016099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383016100 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383016101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383016103 putative substrate translocation pore; other site 469383016104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383016106 S-adenosylmethionine binding site [chemical binding]; other site 469383016107 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 469383016108 homotrimer interaction site [polypeptide binding]; other site 469383016109 putative active site [active] 469383016110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016111 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 469383016112 putative substrate translocation pore; other site 469383016113 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 469383016114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383016115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383016116 homodimer interface [polypeptide binding]; other site 469383016117 catalytic residue [active] 469383016118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 469383016119 NMT1/THI5 like; Region: NMT1; pfam09084 469383016120 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 469383016121 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 469383016122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016123 dimer interface [polypeptide binding]; other site 469383016124 conserved gate region; other site 469383016125 putative PBP binding loops; other site 469383016126 ABC-ATPase subunit interface; other site 469383016127 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 469383016128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016129 dimer interface [polypeptide binding]; other site 469383016130 conserved gate region; other site 469383016131 putative PBP binding loops; other site 469383016132 ABC-ATPase subunit interface; other site 469383016133 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 469383016134 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 469383016135 Walker A/P-loop; other site 469383016136 ATP binding site [chemical binding]; other site 469383016137 Q-loop/lid; other site 469383016138 ABC transporter signature motif; other site 469383016139 Walker B; other site 469383016140 D-loop; other site 469383016141 H-loop/switch region; other site 469383016142 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 469383016143 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 469383016144 active site residue [active] 469383016145 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 469383016146 active site residue [active] 469383016147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 469383016150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016152 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 469383016153 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 469383016154 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 469383016155 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 469383016156 NAD(P) binding pocket [chemical binding]; other site 469383016157 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 469383016158 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 469383016159 dimer interface [polypeptide binding]; other site 469383016160 PYR/PP interface [polypeptide binding]; other site 469383016161 TPP binding site [chemical binding]; other site 469383016162 substrate binding site [chemical binding]; other site 469383016163 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383016164 TPP-binding site [chemical binding]; other site 469383016165 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 469383016166 Transcriptional regulators [Transcription]; Region: FadR; COG2186 469383016167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383016168 DNA-binding site [nucleotide binding]; DNA binding site 469383016169 FCD domain; Region: FCD; pfam07729 469383016170 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 469383016171 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383016172 DNA binding residues [nucleotide binding] 469383016173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 469383016174 sequence-specific DNA binding site [nucleotide binding]; other site 469383016175 salt bridge; other site 469383016176 Cupin domain; Region: Cupin_2; pfam07883 469383016177 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 469383016178 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 469383016179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383016180 SnoaL-like domain; Region: SnoaL_3; pfam13474 469383016181 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 469383016182 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 469383016183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383016184 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 469383016185 active site 469383016186 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 469383016187 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 469383016188 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 469383016189 FtsX-like permease family; Region: FtsX; pfam02687 469383016190 FtsX-like permease family; Region: FtsX; pfam02687 469383016191 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 469383016192 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 469383016193 Walker A/P-loop; other site 469383016194 ATP binding site [chemical binding]; other site 469383016195 Q-loop/lid; other site 469383016196 ABC transporter signature motif; other site 469383016197 Walker B; other site 469383016198 D-loop; other site 469383016199 H-loop/switch region; other site 469383016200 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 469383016201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383016202 Walker A/P-loop; other site 469383016203 ATP binding site [chemical binding]; other site 469383016204 Q-loop/lid; other site 469383016205 ABC transporter signature motif; other site 469383016206 Walker B; other site 469383016207 D-loop; other site 469383016208 H-loop/switch region; other site 469383016209 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383016210 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 469383016211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383016212 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 469383016213 Htaa; Region: HtaA; pfam04213 469383016214 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 469383016215 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 469383016216 putative active site [active] 469383016217 putative ligand binding site [chemical binding]; other site 469383016218 putative NAD(P) binding site [chemical binding]; other site 469383016219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383016220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383016221 active site 469383016222 phosphorylation site [posttranslational modification] 469383016223 intermolecular recognition site; other site 469383016224 dimerization interface [polypeptide binding]; other site 469383016225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383016226 DNA binding residues [nucleotide binding] 469383016227 dimerization interface [polypeptide binding]; other site 469383016228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 469383016229 Histidine kinase; Region: HisKA_3; pfam07730 469383016230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383016231 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383016232 Walker A/P-loop; other site 469383016233 ATP binding site [chemical binding]; other site 469383016234 Q-loop/lid; other site 469383016235 ABC transporter signature motif; other site 469383016236 Walker B; other site 469383016237 D-loop; other site 469383016238 H-loop/switch region; other site 469383016239 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 469383016240 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 469383016241 nucleotide binding pocket [chemical binding]; other site 469383016242 K-X-D-G motif; other site 469383016243 catalytic site [active] 469383016244 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 469383016245 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 469383016246 MMPL family; Region: MMPL; pfam03176 469383016247 MMPL family; Region: MMPL; pfam03176 469383016248 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 469383016249 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 469383016250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383016251 DNA-binding site [nucleotide binding]; DNA binding site 469383016252 UTRA domain; Region: UTRA; pfam07702 469383016253 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 469383016254 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 469383016255 putative ligand binding site [chemical binding]; other site 469383016256 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469383016257 dimer interface [polypeptide binding]; other site 469383016258 active site 469383016259 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 469383016260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 469383016261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 469383016262 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 469383016263 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383016264 active site 469383016265 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 469383016266 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 469383016267 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 469383016268 G1 box; other site 469383016269 GTP/Mg2+ binding site [chemical binding]; other site 469383016270 G2 box; other site 469383016271 Switch I region; other site 469383016272 G3 box; other site 469383016273 Switch II region; other site 469383016274 G4 box; other site 469383016275 G5 box; other site 469383016276 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 469383016277 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 469383016278 Phosphotransferase enzyme family; Region: APH; pfam01636 469383016279 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383016280 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 469383016281 active site 469383016282 catalytic residues [active] 469383016283 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 469383016284 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 469383016285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 469383016286 short chain dehydrogenase; Provisional; Region: PRK06523 469383016287 classical (c) SDRs; Region: SDR_c; cd05233 469383016288 NAD(P) binding site [chemical binding]; other site 469383016289 active site 469383016290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016292 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 469383016293 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 469383016294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383016295 Walker A/P-loop; other site 469383016296 ATP binding site [chemical binding]; other site 469383016297 Q-loop/lid; other site 469383016298 ABC transporter signature motif; other site 469383016299 Walker B; other site 469383016300 D-loop; other site 469383016301 H-loop/switch region; other site 469383016302 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 469383016303 ABC-2 type transporter; Region: ABC2_membrane; cl17235 469383016304 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383016305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383016306 active site 469383016307 phosphorylation site [posttranslational modification] 469383016308 intermolecular recognition site; other site 469383016309 dimerization interface [polypeptide binding]; other site 469383016310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383016311 DNA binding residues [nucleotide binding] 469383016312 dimerization interface [polypeptide binding]; other site 469383016313 Histidine kinase; Region: HisKA_3; pfam07730 469383016314 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383016315 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 469383016316 Walker A/P-loop; other site 469383016317 ATP binding site [chemical binding]; other site 469383016318 Q-loop/lid; other site 469383016319 ABC transporter signature motif; other site 469383016320 Walker B; other site 469383016321 D-loop; other site 469383016322 H-loop/switch region; other site 469383016323 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 469383016324 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 469383016325 Fatty acid desaturase; Region: FA_desaturase; pfam00487 469383016326 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 469383016327 putative di-iron ligands [ion binding]; other site 469383016328 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 469383016329 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 469383016330 FAD binding pocket [chemical binding]; other site 469383016331 FAD binding motif [chemical binding]; other site 469383016332 phosphate binding motif [ion binding]; other site 469383016333 beta-alpha-beta structure motif; other site 469383016334 NAD binding pocket [chemical binding]; other site 469383016335 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 469383016336 catalytic loop [active] 469383016337 iron binding site [ion binding]; other site 469383016338 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 469383016339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016340 NMT1/THI5 like; Region: NMT1; pfam09084 469383016341 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 469383016342 short chain dehydrogenase; Provisional; Region: PRK07832 469383016343 classical (c) SDRs; Region: SDR_c; cd05233 469383016344 NAD(P) binding site [chemical binding]; other site 469383016345 active site 469383016346 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 469383016347 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 469383016348 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 469383016349 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383016350 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 469383016351 DNA binding residues [nucleotide binding] 469383016352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016355 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383016356 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 469383016357 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 469383016358 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 469383016359 conserved cys residue [active] 469383016360 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 469383016361 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 469383016362 conserved cys residue [active] 469383016363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383016364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383016365 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 469383016366 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 469383016367 Domain of unknown function DUF21; Region: DUF21; pfam01595 469383016368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 469383016369 FOG: CBS domain [General function prediction only]; Region: COG0517 469383016370 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 469383016371 Domain of unknown function DUF21; Region: DUF21; pfam01595 469383016372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 469383016373 Transporter associated domain; Region: CorC_HlyC; smart01091 469383016374 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 469383016375 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 469383016376 Serine hydrolase (FSH1); Region: FSH1; pfam03959 469383016377 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 469383016378 putative active site [active] 469383016379 catalytic site [active] 469383016380 SnoaL-like domain; Region: SnoaL_2; pfam12680 469383016381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016383 Domain of unknown function DUF11; Region: DUF11; pfam01345 469383016384 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383016385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016387 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 469383016388 putative active site [active] 469383016389 putative metal binding site [ion binding]; other site 469383016390 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383016391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383016392 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383016393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383016396 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 469383016397 dimer interface [polypeptide binding]; other site 469383016398 Alkaline phosphatase homologues; Region: alkPPc; smart00098 469383016399 active site 469383016400 Fic family protein [Function unknown]; Region: COG3177 469383016401 Fic/DOC family; Region: Fic; pfam02661 469383016402 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 469383016403 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469383016404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383016405 Walker B; other site 469383016406 D-loop; other site 469383016407 H-loop/switch region; other site 469383016408 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 469383016409 malate synthase; Validated; Region: PRK09255 469383016410 malate synthase A; Region: malate_syn_A; TIGR01344 469383016411 active site 469383016412 cytosine deaminase; Validated; Region: PRK07572 469383016413 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 469383016414 active site 469383016415 hypothetical protein; Provisional; Region: PRK11171 469383016416 Cupin domain; Region: Cupin_2; cl17218 469383016417 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 469383016418 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 469383016419 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 469383016420 active site 469383016421 cytosine deaminase; Provisional; Region: PRK05985 469383016422 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 469383016423 active site 469383016424 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 469383016425 putative substrate binding pocket [chemical binding]; other site 469383016426 AC domain interface; other site 469383016427 catalytic triad [active] 469383016428 AB domain interface; other site 469383016429 interchain disulfide; other site 469383016430 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383016431 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383016432 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383016433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383016434 Walker A/P-loop; other site 469383016435 ATP binding site [chemical binding]; other site 469383016436 Q-loop/lid; other site 469383016437 ABC transporter signature motif; other site 469383016438 Walker B; other site 469383016439 D-loop; other site 469383016440 H-loop/switch region; other site 469383016441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383016442 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 469383016443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 469383016444 Walker A/P-loop; other site 469383016445 ATP binding site [chemical binding]; other site 469383016446 Q-loop/lid; other site 469383016447 ABC transporter signature motif; other site 469383016448 Walker B; other site 469383016449 D-loop; other site 469383016450 H-loop/switch region; other site 469383016451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 469383016452 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 469383016453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016454 dimer interface [polypeptide binding]; other site 469383016455 conserved gate region; other site 469383016456 putative PBP binding loops; other site 469383016457 ABC-ATPase subunit interface; other site 469383016458 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383016459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016460 dimer interface [polypeptide binding]; other site 469383016461 conserved gate region; other site 469383016462 ABC-ATPase subunit interface; other site 469383016463 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 469383016464 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 469383016465 Transcriptional regulators [Transcription]; Region: GntR; COG1802 469383016466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 469383016467 DNA-binding site [nucleotide binding]; DNA binding site 469383016468 FCD domain; Region: FCD; pfam07729 469383016469 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383016470 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 469383016471 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 469383016472 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 469383016473 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 469383016474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016476 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 469383016477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383016478 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 469383016479 Walker A/P-loop; other site 469383016480 ATP binding site [chemical binding]; other site 469383016481 Q-loop/lid; other site 469383016482 ABC transporter signature motif; other site 469383016483 Walker B; other site 469383016484 D-loop; other site 469383016485 H-loop/switch region; other site 469383016486 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 469383016487 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 469383016488 Uncharacterized conserved protein [Function unknown]; Region: COG2308 469383016489 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 469383016490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 469383016491 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 469383016492 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 469383016493 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 469383016494 PspC domain; Region: PspC; pfam04024 469383016495 PspC domain; Region: PspC; pfam04024 469383016496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383016497 ATP binding site [chemical binding]; other site 469383016498 Mg2+ binding site [ion binding]; other site 469383016499 G-X-G motif; other site 469383016500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383016501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383016502 DNA binding residues [nucleotide binding] 469383016503 dimerization interface [polypeptide binding]; other site 469383016504 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 469383016505 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 469383016506 Iron permease FTR1 family; Region: FTR1; cl00475 469383016507 FG-GAP repeat; Region: FG-GAP; cl15299 469383016508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383016509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383016510 active site 469383016511 phosphorylation site [posttranslational modification] 469383016512 intermolecular recognition site; other site 469383016513 dimerization interface [polypeptide binding]; other site 469383016514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383016515 DNA binding site [nucleotide binding] 469383016516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016517 putative substrate translocation pore; other site 469383016518 Predicted transcriptional regulators [Transcription]; Region: COG1695 469383016519 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 469383016520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383016521 NADH(P)-binding; Region: NAD_binding_10; pfam13460 469383016522 NAD(P) binding site [chemical binding]; other site 469383016523 active site 469383016524 Cupin; Region: Cupin_6; pfam12852 469383016525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383016526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 469383016527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 469383016528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016530 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 469383016531 Rubredoxin; Region: Rubredoxin; pfam00301 469383016532 iron binding site [ion binding]; other site 469383016533 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 469383016534 Fatty acid desaturase; Region: FA_desaturase; pfam00487 469383016535 Di-iron ligands [ion binding]; other site 469383016536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383016537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383016538 dimer interface [polypeptide binding]; other site 469383016539 phosphorylation site [posttranslational modification] 469383016540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383016541 ATP binding site [chemical binding]; other site 469383016542 Mg2+ binding site [ion binding]; other site 469383016543 G-X-G motif; other site 469383016544 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 469383016545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 469383016546 Walker A/P-loop; other site 469383016547 ATP binding site [chemical binding]; other site 469383016548 Q-loop/lid; other site 469383016549 ABC transporter signature motif; other site 469383016550 Walker B; other site 469383016551 D-loop; other site 469383016552 H-loop/switch region; other site 469383016553 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 469383016554 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 469383016555 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 469383016556 putative active site [active] 469383016557 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 469383016558 ligand-binding site [chemical binding]; other site 469383016559 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 469383016560 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 469383016561 active site 469383016562 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 469383016563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 469383016565 putative substrate translocation pore; other site 469383016566 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383016567 Sulfatase; Region: Sulfatase; cl17466 469383016568 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 469383016569 Sulfatase; Region: Sulfatase; cl17466 469383016570 YibE/F-like protein; Region: YibE_F; pfam07907 469383016571 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 469383016572 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 469383016573 ABC-ATPase subunit interface; other site 469383016574 dimer interface [polypeptide binding]; other site 469383016575 putative PBP binding regions; other site 469383016576 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 469383016577 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 469383016578 ABC-ATPase subunit interface; other site 469383016579 dimer interface [polypeptide binding]; other site 469383016580 putative PBP binding regions; other site 469383016581 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 469383016582 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 469383016583 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 469383016584 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 469383016585 intersubunit interface [polypeptide binding]; other site 469383016586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 469383016588 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 469383016589 catalytic residues [active] 469383016590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 469383016591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 469383016592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 469383016593 dimerization interface [polypeptide binding]; other site 469383016594 camphor resistance protein CrcB; Provisional; Region: PRK14216 469383016595 camphor resistance protein CrcB; Provisional; Region: PRK14228 469383016596 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 469383016597 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 469383016598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 469383016599 RNA binding surface [nucleotide binding]; other site 469383016600 S4 domain; Region: S4_2; pfam13275 469383016601 MarR family; Region: MarR_2; pfam12802 469383016602 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 469383016603 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 469383016604 Cu(I) binding site [ion binding]; other site 469383016605 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 469383016606 substrate binding site [chemical binding]; other site 469383016607 putative active site [active] 469383016608 redox center [active] 469383016609 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 469383016610 Thioredoxin; Region: Thioredoxin_4; pfam13462 469383016611 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 469383016612 CopC domain; Region: CopC; cl01012 469383016613 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 469383016614 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 469383016615 CopC domain; Region: CopC; pfam04234 469383016616 Copper resistance protein D; Region: CopD; cl00563 469383016617 YtkA-like; Region: YtkA; pfam13115 469383016618 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 469383016619 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383016620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383016621 AAA ATPase domain; Region: AAA_16; pfam13191 469383016622 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 469383016623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 469383016624 DNA binding residues [nucleotide binding] 469383016625 dimerization interface [polypeptide binding]; other site 469383016626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 469383016627 NAD(P) binding site [chemical binding]; other site 469383016628 active site 469383016629 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 469383016630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383016631 Zn2+ binding site [ion binding]; other site 469383016632 Mg2+ binding site [ion binding]; other site 469383016633 Predicted transcriptional regulator [Transcription]; Region: COG2378 469383016634 WYL domain; Region: WYL; pfam13280 469383016635 Predicted transcriptional regulator [Transcription]; Region: COG2378 469383016636 WYL domain; Region: WYL; pfam13280 469383016637 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 469383016638 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 469383016639 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 469383016640 substrate binding site; other site 469383016641 metal-binding site 469383016642 Oligomer interface; other site 469383016643 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 469383016644 putative CoA binding site [chemical binding]; other site 469383016645 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 469383016646 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 469383016647 NADP binding site [chemical binding]; other site 469383016648 active site 469383016649 putative substrate binding site [chemical binding]; other site 469383016650 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 469383016651 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 469383016652 NAD binding site [chemical binding]; other site 469383016653 substrate binding site [chemical binding]; other site 469383016654 homodimer interface [polypeptide binding]; other site 469383016655 active site 469383016656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 469383016657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 469383016658 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 469383016659 Fe-S cluster binding site [ion binding]; other site 469383016660 DNA binding site [nucleotide binding] 469383016661 active site 469383016662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383016663 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 469383016664 ATP binding site [chemical binding]; other site 469383016665 putative Mg++ binding site [ion binding]; other site 469383016666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 469383016667 nucleotide binding region [chemical binding]; other site 469383016668 ATP-binding site [chemical binding]; other site 469383016669 DEAD/H associated; Region: DEAD_assoc; pfam08494 469383016670 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 469383016671 alpha-galactosidase; Provisional; Region: PRK15076 469383016672 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 469383016673 NAD binding site [chemical binding]; other site 469383016674 sugar binding site [chemical binding]; other site 469383016675 divalent metal binding site [ion binding]; other site 469383016676 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 469383016677 dimer interface [polypeptide binding]; other site 469383016678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 469383016679 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 469383016680 substrate binding site [chemical binding]; other site 469383016681 ATP binding site [chemical binding]; other site 469383016682 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 469383016683 substrate binding site [chemical binding]; other site 469383016684 ATP binding site [chemical binding]; other site 469383016685 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 469383016686 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 469383016687 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 469383016688 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 469383016689 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 469383016690 Walker A/P-loop; other site 469383016691 ATP binding site [chemical binding]; other site 469383016692 Q-loop/lid; other site 469383016693 ABC transporter signature motif; other site 469383016694 Walker B; other site 469383016695 D-loop; other site 469383016696 H-loop/switch region; other site 469383016697 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 469383016698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016699 dimer interface [polypeptide binding]; other site 469383016700 conserved gate region; other site 469383016701 putative PBP binding loops; other site 469383016702 ABC-ATPase subunit interface; other site 469383016703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 469383016704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016705 ABC-ATPase subunit interface; other site 469383016706 putative PBP binding loops; other site 469383016707 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 469383016708 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 469383016709 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 469383016710 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 469383016711 dimer interface [polypeptide binding]; other site 469383016712 active site 469383016713 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 469383016714 dimer interface [polypeptide binding]; other site 469383016715 active site 469383016716 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 469383016717 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 469383016718 putative DNA binding site [nucleotide binding]; other site 469383016719 catalytic residue [active] 469383016720 putative H2TH interface [polypeptide binding]; other site 469383016721 putative catalytic residues [active] 469383016722 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 469383016723 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 469383016724 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 469383016725 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 469383016726 active site 469383016727 catalytic site [active] 469383016728 metal binding site [ion binding]; metal-binding site 469383016729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 469383016730 DNA binding residues [nucleotide binding] 469383016731 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 469383016732 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 469383016733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 469383016734 ligand binding site [chemical binding]; other site 469383016735 flexible hinge region; other site 469383016736 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 469383016737 non-specific DNA interactions [nucleotide binding]; other site 469383016738 DNA binding site [nucleotide binding] 469383016739 sequence specific DNA binding site [nucleotide binding]; other site 469383016740 putative cAMP binding site [chemical binding]; other site 469383016741 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 469383016742 nudix motif; other site 469383016743 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 469383016744 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 469383016745 oligomerisation interface [polypeptide binding]; other site 469383016746 mobile loop; other site 469383016747 roof hairpin; other site 469383016748 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 469383016749 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 469383016750 ring oligomerisation interface [polypeptide binding]; other site 469383016751 ATP/Mg binding site [chemical binding]; other site 469383016752 stacking interactions; other site 469383016753 hinge regions; other site 469383016754 Divergent AAA domain; Region: AAA_4; pfam04326 469383016755 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 469383016756 citrate synthase 2; Provisional; Region: PRK12350 469383016757 Citrate synthase; Region: Citrate_synt; pfam00285 469383016758 oxalacetate binding site [chemical binding]; other site 469383016759 citrylCoA binding site [chemical binding]; other site 469383016760 coenzyme A binding site [chemical binding]; other site 469383016761 catalytic triad [active] 469383016762 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 469383016763 Amidase; Region: Amidase; pfam01425 469383016764 Short C-terminal domain; Region: SHOCT; pfam09851 469383016765 Ferredoxin [Energy production and conversion]; Region: COG1146 469383016766 4Fe-4S binding domain; Region: Fer4; cl02805 469383016767 Domain of unknown function DUF59; Region: DUF59; cl00941 469383016768 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 469383016769 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 469383016770 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 469383016771 active site 469383016772 metal binding site [ion binding]; metal-binding site 469383016773 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 469383016774 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 469383016775 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 469383016776 active site 469383016777 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 469383016778 Family description; Region: UvrD_C_2; pfam13538 469383016779 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 469383016780 PAC2 family; Region: PAC2; pfam09754 469383016781 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 469383016782 generic binding surface II; other site 469383016783 generic binding surface I; other site 469383016784 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383016785 Zn2+ binding site [ion binding]; other site 469383016786 Mg2+ binding site [ion binding]; other site 469383016787 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 469383016788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 469383016789 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 469383016790 TrkA-C domain; Region: TrkA_C; pfam02080 469383016791 Predicted transcriptional regulators [Transcription]; Region: COG1733 469383016792 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 469383016793 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 469383016794 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 469383016795 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 469383016796 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 469383016797 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 469383016798 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383016799 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 469383016800 active site 469383016801 metal binding site [ion binding]; metal-binding site 469383016802 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 469383016803 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 469383016804 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 469383016805 active site 469383016806 metal binding site [ion binding]; metal-binding site 469383016807 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 469383016808 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 469383016809 hypothetical protein; Provisional; Region: PRK08609 469383016810 active site 469383016811 primer binding site [nucleotide binding]; other site 469383016812 NTP binding site [chemical binding]; other site 469383016813 metal binding triad [ion binding]; metal-binding site 469383016814 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 469383016815 active site 469383016816 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 469383016817 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469383016818 catalytic residues [active] 469383016819 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 469383016820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 469383016821 dimerization interface [polypeptide binding]; other site 469383016822 putative DNA binding site [nucleotide binding]; other site 469383016823 putative Zn2+ binding site [ion binding]; other site 469383016824 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 469383016825 Clp protease; Region: CLP_protease; pfam00574 469383016826 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 469383016827 oligomer interface [polypeptide binding]; other site 469383016828 active site residues [active] 469383016829 Phosphotransferase enzyme family; Region: APH; pfam01636 469383016830 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383016831 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 469383016832 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 469383016833 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 469383016834 HIGH motif; other site 469383016835 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 469383016836 active site 469383016837 KMSKS motif; other site 469383016838 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 469383016839 tRNA binding surface [nucleotide binding]; other site 469383016840 anticodon binding site; other site 469383016841 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383016842 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383016843 DNA binding residues [nucleotide binding] 469383016844 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 469383016845 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 469383016846 DNA binding residues [nucleotide binding] 469383016847 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 469383016848 Zn2+ binding site [ion binding]; other site 469383016849 Mg2+ binding site [ion binding]; other site 469383016850 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 469383016851 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 469383016852 TAP-like protein; Region: Abhydrolase_4; pfam08386 469383016853 fumarate hydratase; Reviewed; Region: fumC; PRK00485 469383016854 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 469383016855 active sites [active] 469383016856 tetramer interface [polypeptide binding]; other site 469383016857 acetolactate synthase; Reviewed; Region: PRK08322 469383016858 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 469383016859 PYR/PP interface [polypeptide binding]; other site 469383016860 dimer interface [polypeptide binding]; other site 469383016861 TPP binding site [chemical binding]; other site 469383016862 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 469383016863 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 469383016864 TPP-binding site [chemical binding]; other site 469383016865 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 469383016866 putative active site [active] 469383016867 putative catalytic site [active] 469383016868 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 469383016869 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 469383016870 active site 469383016871 metal binding site 1 [ion binding]; metal-binding site 469383016872 putative 5' ssDNA interaction site; other site 469383016873 metal binding site 3; metal-binding site 469383016874 metal binding site 2 [ion binding]; metal-binding site 469383016875 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 469383016876 putative DNA binding site [nucleotide binding]; other site 469383016877 putative metal binding site [ion binding]; other site 469383016878 GTP-binding protein YchF; Reviewed; Region: PRK09601 469383016879 YchF GTPase; Region: YchF; cd01900 469383016880 G1 box; other site 469383016881 GTP/Mg2+ binding site [chemical binding]; other site 469383016882 Switch I region; other site 469383016883 G2 box; other site 469383016884 Switch II region; other site 469383016885 G3 box; other site 469383016886 G4 box; other site 469383016887 G5 box; other site 469383016888 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 469383016889 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 469383016890 active site 469383016891 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 469383016892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 469383016893 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 469383016894 dimer interface [polypeptide binding]; other site 469383016895 substrate binding site [chemical binding]; other site 469383016896 metal binding site [ion binding]; metal-binding site 469383016897 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 469383016898 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 469383016899 active site 469383016900 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 469383016901 hypothetical protein; Provisional; Region: PRK07906 469383016902 putative metal binding site [ion binding]; other site 469383016903 recombination factor protein RarA; Reviewed; Region: PRK13342 469383016904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 469383016905 Walker A motif; other site 469383016906 ATP binding site [chemical binding]; other site 469383016907 Walker B motif; other site 469383016908 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 469383016909 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 469383016910 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 469383016911 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 469383016912 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 469383016913 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 469383016914 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 469383016915 DNA binding residues [nucleotide binding] 469383016916 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 469383016917 conserved cys residue [active] 469383016918 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 469383016919 trimer interface [polypeptide binding]; other site 469383016920 dimer interface [polypeptide binding]; other site 469383016921 putative active site [active] 469383016922 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 469383016923 MPT binding site; other site 469383016924 trimer interface [polypeptide binding]; other site 469383016925 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 469383016926 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383016927 Walker A/P-loop; other site 469383016928 ATP binding site [chemical binding]; other site 469383016929 Q-loop/lid; other site 469383016930 ABC transporter signature motif; other site 469383016931 Walker B; other site 469383016932 D-loop; other site 469383016933 H-loop/switch region; other site 469383016934 CcmB protein; Region: CcmB; cl17444 469383016935 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 469383016936 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 469383016937 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 469383016938 tRNA; other site 469383016939 putative tRNA binding site [nucleotide binding]; other site 469383016940 putative NADP binding site [chemical binding]; other site 469383016941 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 469383016942 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 469383016943 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 469383016944 domain interfaces; other site 469383016945 active site 469383016946 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 469383016947 active site 469383016948 SAM binding site [chemical binding]; other site 469383016949 homodimer interface [polypeptide binding]; other site 469383016950 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 469383016951 active site 469383016952 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 469383016953 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 469383016954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 469383016955 ATP binding site [chemical binding]; other site 469383016956 putative Mg++ binding site [ion binding]; other site 469383016957 nucleotide binding region [chemical binding]; other site 469383016958 helicase superfamily c-terminal domain; Region: HELICc; smart00490 469383016959 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 469383016960 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 469383016961 catalytic residues [active] 469383016962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 469383016963 ADP-glucose phosphorylase; Region: PLN02643 469383016964 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 469383016965 nucleotide binding site/active site [active] 469383016966 HIT family signature motif; other site 469383016967 catalytic residue [active] 469383016968 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 469383016969 putative active site [active] 469383016970 dimerization interface [polypeptide binding]; other site 469383016971 putative tRNAtyr binding site [nucleotide binding]; other site 469383016972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 469383016973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016974 dimer interface [polypeptide binding]; other site 469383016975 conserved gate region; other site 469383016976 ABC-ATPase subunit interface; other site 469383016977 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 469383016978 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 469383016979 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 469383016980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 469383016981 dimer interface [polypeptide binding]; other site 469383016982 conserved gate region; other site 469383016983 putative PBP binding loops; other site 469383016984 ABC-ATPase subunit interface; other site 469383016985 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 469383016986 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 469383016987 active site 469383016988 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 469383016989 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 469383016990 CAAX protease self-immunity; Region: Abi; pfam02517 469383016991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 469383016992 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 469383016993 motif II; other site 469383016994 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 469383016995 Mechanosensitive ion channel; Region: MS_channel; pfam00924 469383016996 Transglycosylase; Region: Transgly; pfam00912 469383016997 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 469383016998 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 469383016999 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 469383017000 rRNA binding site [nucleotide binding]; other site 469383017001 predicted 30S ribosome binding site; other site 469383017002 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 469383017003 thiamine monophosphate kinase; Provisional; Region: PRK05731 469383017004 ATP binding site [chemical binding]; other site 469383017005 dimerization interface [polypeptide binding]; other site 469383017006 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 469383017007 active site 469383017008 catalytic site [active] 469383017009 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 469383017010 metal binding site [ion binding]; metal-binding site 469383017011 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 469383017012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 469383017013 active site 469383017014 phosphorylation site [posttranslational modification] 469383017015 intermolecular recognition site; other site 469383017016 dimerization interface [polypeptide binding]; other site 469383017017 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 469383017018 DNA binding site [nucleotide binding] 469383017019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 469383017020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 469383017021 dimerization interface [polypeptide binding]; other site 469383017022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 469383017023 dimer interface [polypeptide binding]; other site 469383017024 phosphorylation site [posttranslational modification] 469383017025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 469383017026 ATP binding site [chemical binding]; other site 469383017027 Mg2+ binding site [ion binding]; other site 469383017028 G-X-G motif; other site 469383017029 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 469383017030 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 469383017031 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 469383017032 protein binding site [polypeptide binding]; other site 469383017033 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 469383017034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 469383017035 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 469383017036 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 469383017037 active site 469383017038 homotetramer interface [polypeptide binding]; other site 469383017039 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 469383017040 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 469383017041 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 469383017042 dimer interface [polypeptide binding]; other site 469383017043 ssDNA binding site [nucleotide binding]; other site 469383017044 tetramer (dimer of dimers) interface [polypeptide binding]; other site 469383017045 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 469383017046 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 469383017047 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 469383017048 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 469383017049 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 469383017050 replicative DNA helicase; Region: DnaB; TIGR00665 469383017051 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 469383017052 Walker A motif; other site 469383017053 ATP binding site [chemical binding]; other site 469383017054 Walker B motif; other site 469383017055 DNA binding loops [nucleotide binding] 469383017056 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 469383017057 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 469383017058 GDP-binding site [chemical binding]; other site 469383017059 ACT binding site; other site 469383017060 IMP binding site; other site 469383017061 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 469383017062 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 469383017063 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 469383017064 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 469383017065 active site 469383017066 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 469383017067 homodimer interface [polypeptide binding]; other site 469383017068 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 469383017069 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 469383017070 homodimer interface [polypeptide binding]; other site 469383017071 substrate-cofactor binding pocket; other site 469383017072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383017073 catalytic residue [active] 469383017074 short chain dehydrogenase; Provisional; Region: PRK07825 469383017075 classical (c) SDRs; Region: SDR_c; cd05233 469383017076 NAD(P) binding site [chemical binding]; other site 469383017077 active site 469383017078 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 469383017079 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 469383017080 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 469383017081 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 469383017082 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 469383017083 substrate binding pocket [chemical binding]; other site 469383017084 chain length determination region; other site 469383017085 substrate-Mg2+ binding site; other site 469383017086 catalytic residues [active] 469383017087 aspartate-rich region 1; other site 469383017088 active site lid residues [active] 469383017089 aspartate-rich region 2; other site 469383017090 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 469383017091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 469383017092 S-adenosylmethionine binding site [chemical binding]; other site 469383017093 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 469383017094 interchain domain interface [polypeptide binding]; other site 469383017095 intrachain domain interface; other site 469383017096 Qi binding site; other site 469383017097 Qo binding site; other site 469383017098 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 469383017099 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 469383017100 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 469383017101 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 469383017102 intrachain domain interface; other site 469383017103 interchain domain interface [polypeptide binding]; other site 469383017104 heme bH binding site [chemical binding]; other site 469383017105 Qi binding site; other site 469383017106 heme bL binding site [chemical binding]; other site 469383017107 Qo binding site; other site 469383017108 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 469383017109 iron-sulfur cluster [ion binding]; other site 469383017110 [2Fe-2S] cluster binding site [ion binding]; other site 469383017111 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 469383017112 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 469383017113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 469383017114 catalytic residue [active] 469383017115 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383017116 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 469383017117 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 469383017118 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 469383017119 dimer interface [polypeptide binding]; other site 469383017120 active site 469383017121 Schiff base residues; other site 469383017122 Predicted membrane protein [Function unknown]; Region: COG1511 469383017123 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 469383017124 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 469383017125 Walker A/P-loop; other site 469383017126 ATP binding site [chemical binding]; other site 469383017127 Q-loop/lid; other site 469383017128 ABC transporter signature motif; other site 469383017129 Walker B; other site 469383017130 D-loop; other site 469383017131 H-loop/switch region; other site 469383017132 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 469383017133 putative active site [active] 469383017134 metal binding site [ion binding]; metal-binding site 469383017135 homodimer binding site [polypeptide binding]; other site 469383017136 Predicted membrane protein [Function unknown]; Region: COG2246 469383017137 GtrA-like protein; Region: GtrA; pfam04138 469383017138 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 469383017139 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 469383017140 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 469383017141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 469383017142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 469383017143 homodimer interface [polypeptide binding]; other site 469383017144 catalytic residue [active] 469383017145 Bifunctional nuclease; Region: DNase-RNase; pfam02577 469383017146 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 469383017147 ParB-like nuclease domain; Region: ParBc; pfam02195 469383017148 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 469383017149 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 469383017150 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 469383017151 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 469383017152 G-X-X-G motif; other site 469383017153 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 469383017154 RxxxH motif; other site 469383017155 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 469383017156 Haemolytic domain; Region: Haemolytic; pfam01809 469383017157 Ribonuclease P; Region: Ribonuclease_P; cl00457 469383017158 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399