-- dump date 20140619_050104 -- class Genbank::misc_feature -- table misc_feature_note -- id note 751585000001 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 751585000002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 751585000003 active site 751585000004 metal binding site [ion binding]; metal-binding site 751585000005 DNA binding site [nucleotide binding] 751585000006 AAA domain; Region: AAA_23; pfam13476 751585000007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000008 Walker A/P-loop; other site 751585000009 ATP binding site [chemical binding]; other site 751585000010 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 751585000011 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585000012 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 751585000013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585000014 ABC transporter; Region: ABC_tran_2; pfam12848 751585000015 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585000016 Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954 751585000017 metal binding triad [ion binding]; metal-binding site 751585000018 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 751585000019 ApbE family; Region: ApbE; pfam02424 751585000020 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 751585000021 trimer interface [polypeptide binding]; other site 751585000022 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 751585000023 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 751585000024 SLBB domain; Region: SLBB; pfam10531 751585000025 4Fe-4S binding domain; Region: Fer4; cl02805 751585000026 electron transport complex RsxE subunit; Provisional; Region: PRK12405 751585000027 Surface protein; Region: DUF3664; pfam12406 751585000028 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 751585000029 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878 751585000030 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 751585000031 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 751585000032 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 751585000033 ATP cone domain; Region: ATP-cone; pfam03477 751585000034 Uncharacterized conserved protein [Function unknown]; Region: COG1739 751585000035 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 751585000036 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 751585000037 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585000038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000039 Walker A/P-loop; other site 751585000040 ATP binding site [chemical binding]; other site 751585000041 Q-loop/lid; other site 751585000042 ABC transporter signature motif; other site 751585000043 Walker B; other site 751585000044 D-loop; other site 751585000045 H-loop/switch region; other site 751585000046 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 751585000047 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 751585000048 protein binding site [polypeptide binding]; other site 751585000049 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 751585000050 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 751585000051 Preprotein translocase subunit; Region: YajC; pfam02699 751585000052 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 751585000053 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 751585000054 GGGtGRT protein; Region: GGGtGRT; pfam14057 751585000055 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 751585000056 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 751585000057 active site 751585000058 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 751585000059 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230 751585000060 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 751585000061 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 751585000062 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 751585000063 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 751585000064 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 751585000065 Type II/IV secretion system protein; Region: T2SE; pfam00437 751585000066 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 751585000067 Walker A motif; other site 751585000068 ATP binding site [chemical binding]; other site 751585000069 Walker B motif; other site 751585000070 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 751585000071 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 751585000072 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 751585000073 Walker A motif; other site 751585000074 ATP binding site [chemical binding]; other site 751585000075 Walker B motif; other site 751585000076 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 751585000077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 751585000078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 751585000079 DNA binding residues [nucleotide binding] 751585000080 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 751585000081 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 751585000082 Peptidase family U32; Region: Peptidase_U32; pfam01136 751585000083 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 751585000084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585000085 S-adenosylmethionine binding site [chemical binding]; other site 751585000086 Protein of unknown function (DUF964); Region: DUF964; pfam06133 751585000087 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 751585000088 hypothetical protein; Provisional; Region: PRK05473 751585000089 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 751585000090 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 751585000091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585000092 FeS/SAM binding site; other site 751585000093 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 751585000094 regulatory protein interface [polypeptide binding]; other site 751585000095 regulatory phosphorylation site [posttranslational modification]; other site 751585000096 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 751585000097 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 751585000098 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 751585000099 Ligand Binding Site [chemical binding]; other site 751585000100 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 751585000101 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 751585000102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 751585000103 catalytic residue [active] 751585000104 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 751585000105 RNA methyltransferase, RsmE family; Region: TIGR00046 751585000106 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 751585000107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585000108 S-adenosylmethionine binding site [chemical binding]; other site 751585000109 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 751585000110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 751585000111 nucleotide binding site [chemical binding]; other site 751585000112 GrpE; Region: GrpE; pfam01025 751585000113 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 751585000114 dimer interface [polypeptide binding]; other site 751585000115 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 751585000116 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 751585000117 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 751585000118 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 751585000119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585000120 FeS/SAM binding site; other site 751585000121 HemN C-terminal domain; Region: HemN_C; pfam06969 751585000122 GTP-binding protein LepA; Provisional; Region: PRK05433 751585000123 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 751585000124 G1 box; other site 751585000125 putative GEF interaction site [polypeptide binding]; other site 751585000126 GTP/Mg2+ binding site [chemical binding]; other site 751585000127 Switch I region; other site 751585000128 G2 box; other site 751585000129 G3 box; other site 751585000130 Switch II region; other site 751585000131 G4 box; other site 751585000132 G5 box; other site 751585000133 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 751585000134 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 751585000135 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 751585000136 stage II sporulation protein P; Region: spore_II_P; TIGR02867 751585000137 Germination protease; Region: Peptidase_A25; cl04057 751585000138 SpoVA protein; Region: SpoVA; pfam03862 751585000139 stage V sporulation protein AD; Provisional; Region: PRK12404 751585000140 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 751585000141 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 751585000142 dimer interface [polypeptide binding]; other site 751585000143 VanW like protein; Region: VanW; pfam04294 751585000144 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 751585000145 SpoVA protein; Region: SpoVA; pfam03862 751585000146 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 751585000147 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 751585000148 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 751585000149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 751585000150 DNA binding residues [nucleotide binding] 751585000151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 751585000152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 751585000153 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 751585000154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585000155 ATP binding site [chemical binding]; other site 751585000156 Mg2+ binding site [ion binding]; other site 751585000157 G-X-G motif; other site 751585000158 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 751585000159 anti sigma factor interaction site; other site 751585000160 regulatory phosphorylation site [posttranslational modification]; other site 751585000161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 751585000162 TPR motif; other site 751585000163 binding surface 751585000164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 751585000165 TPR motif; other site 751585000166 binding surface 751585000167 Tetratricopeptide repeat; Region: TPR_16; pfam13432 751585000168 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 751585000169 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 751585000170 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 751585000171 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 751585000172 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 751585000173 acetylornithine aminotransferase; Provisional; Region: PRK02627 751585000174 inhibitor-cofactor binding pocket; inhibition site 751585000175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585000176 catalytic residue [active] 751585000177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585000178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585000179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000180 Walker A/P-loop; other site 751585000181 ATP binding site [chemical binding]; other site 751585000182 Q-loop/lid; other site 751585000183 ABC transporter signature motif; other site 751585000184 Walker B; other site 751585000185 D-loop; other site 751585000186 H-loop/switch region; other site 751585000187 hypothetical protein; Validated; Region: PRK00110 751585000188 FOG: CBS domain [General function prediction only]; Region: COG0517 751585000189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 751585000190 Transporter associated domain; Region: CorC_HlyC; pfam03471 751585000191 alanine racemase; Reviewed; Region: alr; PRK00053 751585000192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 751585000193 active site 751585000194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 751585000195 dimer interface [polypeptide binding]; other site 751585000196 substrate binding site [chemical binding]; other site 751585000197 catalytic residues [active] 751585000198 Uncharacterized conserved protein [Function unknown]; Region: COG0062 751585000199 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 751585000200 putative substrate binding site [chemical binding]; other site 751585000201 putative ATP binding site [chemical binding]; other site 751585000202 Cell division protein FtsQ; Region: FtsQ; pfam03799 751585000203 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 751585000204 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 751585000205 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 751585000206 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 751585000207 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 751585000208 Mg++ binding site [ion binding]; other site 751585000209 putative catalytic motif [active] 751585000210 putative substrate binding site [chemical binding]; other site 751585000211 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 751585000212 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 751585000213 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 751585000214 MraW methylase family; Region: Methyltransf_5; pfam01795 751585000215 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 751585000216 MraZ protein; Region: MraZ; pfam02381 751585000217 cell division protein MraZ; Reviewed; Region: PRK00326 751585000218 MraZ protein; Region: MraZ; pfam02381 751585000219 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 751585000220 Response regulator receiver domain; Region: Response_reg; pfam00072 751585000221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585000222 active site 751585000223 phosphorylation site [posttranslational modification] 751585000224 intermolecular recognition site; other site 751585000225 dimerization interface [polypeptide binding]; other site 751585000226 H+ Antiporter protein; Region: 2A0121; TIGR00900 751585000227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 751585000228 putative substrate translocation pore; other site 751585000229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585000230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585000231 non-specific DNA binding site [nucleotide binding]; other site 751585000232 salt bridge; other site 751585000233 sequence-specific DNA binding site [nucleotide binding]; other site 751585000234 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 751585000235 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 751585000236 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 751585000237 catalytic residues [active] 751585000238 catalytic nucleophile [active] 751585000239 Presynaptic Site I dimer interface [polypeptide binding]; other site 751585000240 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 751585000241 Synaptic Flat tetramer interface [polypeptide binding]; other site 751585000242 Synaptic Site I dimer interface [polypeptide binding]; other site 751585000243 DNA binding site [nucleotide binding] 751585000244 Recombinase; Region: Recombinase; pfam07508 751585000245 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 751585000246 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585000247 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 751585000248 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 751585000249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 751585000250 putative DNA binding site [nucleotide binding]; other site 751585000251 putative Zn2+ binding site [ion binding]; other site 751585000252 Chromate transporter; Region: Chromate_transp; pfam02417 751585000253 Chromate transporter; Region: Chromate_transp; pfam02417 751585000254 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 751585000255 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 751585000256 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 751585000257 putative hydratase; Provisional; Region: PRK11413 751585000258 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 751585000259 substrate binding site [chemical binding]; other site 751585000260 ligand binding site [chemical binding]; other site 751585000261 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 751585000262 substrate binding site [chemical binding]; other site 751585000263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585000264 ATP binding site [chemical binding]; other site 751585000265 Mg2+ binding site [ion binding]; other site 751585000266 G-X-G motif; other site 751585000267 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 751585000268 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 751585000269 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 751585000270 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 751585000271 dimer interface [polypeptide binding]; other site 751585000272 PYR/PP interface [polypeptide binding]; other site 751585000273 TPP binding site [chemical binding]; other site 751585000274 substrate binding site [chemical binding]; other site 751585000275 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 751585000276 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 751585000277 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 751585000278 TPP-binding site [chemical binding]; other site 751585000279 putative dimer interface [polypeptide binding]; other site 751585000280 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 751585000281 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 751585000282 trehalose synthase; Region: treS_nterm; TIGR02456 751585000283 active site 751585000284 catalytic site [active] 751585000285 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 751585000286 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 751585000287 putative substrate binding site [chemical binding]; other site 751585000288 putative ATP binding site [chemical binding]; other site 751585000289 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 751585000290 DNA-binding site [nucleotide binding]; DNA binding site 751585000291 RNA-binding motif; other site 751585000292 glycogen branching enzyme; Provisional; Region: PRK05402 751585000293 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 751585000294 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 751585000295 active site 751585000296 catalytic site [active] 751585000297 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 751585000298 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 751585000299 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 751585000300 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 751585000301 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 751585000302 active site 751585000303 multimer interface [polypeptide binding]; other site 751585000304 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 751585000305 predicted active site [active] 751585000306 catalytic triad [active] 751585000307 Uncharacterized conserved protein [Function unknown]; Region: COG1284 751585000308 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 751585000309 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 751585000310 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 751585000311 Sporulation and spore germination; Region: Germane; pfam10646 751585000312 Sporulation and spore germination; Region: Germane; pfam10646 751585000313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585000314 dimer interface [polypeptide binding]; other site 751585000315 phosphorylation site [posttranslational modification] 751585000316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585000317 ATP binding site [chemical binding]; other site 751585000318 Mg2+ binding site [ion binding]; other site 751585000319 G-X-G motif; other site 751585000320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585000321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585000322 active site 751585000323 phosphorylation site [posttranslational modification] 751585000324 intermolecular recognition site; other site 751585000325 dimerization interface [polypeptide binding]; other site 751585000326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585000327 DNA binding site [nucleotide binding] 751585000328 SLBB domain; Region: SLBB; pfam10531 751585000329 comEA protein; Region: comE; TIGR01259 751585000330 Helix-hairpin-helix motif; Region: HHH; pfam00633 751585000331 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 751585000332 feedback inhibition sensing region; other site 751585000333 homohexameric interface [polypeptide binding]; other site 751585000334 nucleotide binding site [chemical binding]; other site 751585000335 N-acetyl-L-glutamate binding site [chemical binding]; other site 751585000336 argininosuccinate synthase; Provisional; Region: PRK13820 751585000337 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 751585000338 ANP binding site [chemical binding]; other site 751585000339 Substrate Binding Site II [chemical binding]; other site 751585000340 Substrate Binding Site I [chemical binding]; other site 751585000341 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 751585000342 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 751585000343 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 751585000344 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 751585000345 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 751585000346 Walker A/P-loop; other site 751585000347 ATP binding site [chemical binding]; other site 751585000348 Q-loop/lid; other site 751585000349 ABC transporter signature motif; other site 751585000350 Walker B; other site 751585000351 D-loop; other site 751585000352 H-loop/switch region; other site 751585000353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585000354 Histidine kinase; Region: HisKA_3; pfam07730 751585000355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585000356 ATP binding site [chemical binding]; other site 751585000357 Mg2+ binding site [ion binding]; other site 751585000358 G-X-G motif; other site 751585000359 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 751585000360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585000361 active site 751585000362 phosphorylation site [posttranslational modification] 751585000363 intermolecular recognition site; other site 751585000364 dimerization interface [polypeptide binding]; other site 751585000365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 751585000366 DNA binding residues [nucleotide binding] 751585000367 dimerization interface [polypeptide binding]; other site 751585000368 Bacterial SH3 domain; Region: SH3_3; pfam08239 751585000369 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 751585000370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 751585000371 RNA binding surface [nucleotide binding]; other site 751585000372 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 751585000373 active site 751585000374 uracil binding [chemical binding]; other site 751585000375 Bacterial SH3 domain; Region: SH3_3; pfam08239 751585000376 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 751585000377 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 751585000378 active site 751585000379 metal binding site [ion binding]; metal-binding site 751585000380 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 751585000381 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 751585000382 active site 751585000383 metal binding site [ion binding]; metal-binding site 751585000384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 751585000385 Tubby C 2; Region: Tub_2; cl02043 751585000386 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 751585000387 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 751585000388 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 751585000389 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 751585000390 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 751585000391 dimer interface [polypeptide binding]; other site 751585000392 motif 1; other site 751585000393 active site 751585000394 motif 2; other site 751585000395 motif 3; other site 751585000396 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 751585000397 Stage II sporulation protein; Region: SpoIID; pfam08486 751585000398 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 751585000399 6-phosphofructokinase; Provisional; Region: PRK14072 751585000400 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 751585000401 active site 751585000402 ADP/pyrophosphate binding site [chemical binding]; other site 751585000403 dimerization interface [polypeptide binding]; other site 751585000404 allosteric effector site; other site 751585000405 fructose-1,6-bisphosphate binding site; other site 751585000406 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 751585000407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 751585000408 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 751585000409 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 751585000410 active site 751585000411 dimer interface [polypeptide binding]; other site 751585000412 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 751585000413 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 751585000414 active site 751585000415 FMN binding site [chemical binding]; other site 751585000416 substrate binding site [chemical binding]; other site 751585000417 3Fe-4S cluster binding site [ion binding]; other site 751585000418 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 751585000419 domain interface; other site 751585000420 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 751585000421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 751585000422 active site 751585000423 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 751585000424 substrate binding site; other site 751585000425 dimerization interface; other site 751585000426 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 751585000427 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 751585000428 Zn-finger in Ran binding protein and others; Region: zf-RanBP; pfam00641 751585000429 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 751585000430 FMN binding site [chemical binding]; other site 751585000431 dimer interface [polypeptide binding]; other site 751585000432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 751585000433 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 751585000434 active site 751585000435 isocitrate dehydrogenase; Validated; Region: PRK08299 751585000436 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 751585000437 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 751585000438 dimerization interface [polypeptide binding]; other site 751585000439 putative Zn2+ binding site [ion binding]; other site 751585000440 putative DNA binding site [nucleotide binding]; other site 751585000441 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 751585000442 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 751585000443 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585000444 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 751585000445 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585000446 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 751585000447 Cupin domain; Region: Cupin_2; pfam07883 751585000448 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 751585000449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585000450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585000451 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 751585000452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585000453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 751585000454 dimerization interface [polypeptide binding]; other site 751585000455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585000456 dimer interface [polypeptide binding]; other site 751585000457 phosphorylation site [posttranslational modification] 751585000458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585000459 ATP binding site [chemical binding]; other site 751585000460 Mg2+ binding site [ion binding]; other site 751585000461 G-X-G motif; other site 751585000462 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 751585000463 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 751585000464 catalytic residues [active] 751585000465 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585000466 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 751585000467 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 751585000468 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 751585000469 GDP-binding site [chemical binding]; other site 751585000470 ACT binding site; other site 751585000471 IMP binding site; other site 751585000472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 751585000473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 751585000474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 751585000475 dimerization interface [polypeptide binding]; other site 751585000476 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 751585000477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585000478 motif II; other site 751585000479 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 751585000480 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 751585000481 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 751585000482 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 751585000483 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 751585000484 Penicillinase repressor; Region: Pencillinase_R; cl17580 751585000485 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 751585000486 Family description; Region: ACT_7; pfam13840 751585000487 MobA/MobL family; Region: MobA_MobL; pfam03389 751585000488 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 751585000489 Helix-turn-helix domain; Region: HTH_17; pfam12728 751585000490 FtsX-like permease family; Region: FtsX; pfam02687 751585000491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585000492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585000493 Walker A/P-loop; other site 751585000494 ATP binding site [chemical binding]; other site 751585000495 Q-loop/lid; other site 751585000496 ABC transporter signature motif; other site 751585000497 Walker B; other site 751585000498 D-loop; other site 751585000499 H-loop/switch region; other site 751585000500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585000501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585000502 dimer interface [polypeptide binding]; other site 751585000503 phosphorylation site [posttranslational modification] 751585000504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585000505 ATP binding site [chemical binding]; other site 751585000506 Mg2+ binding site [ion binding]; other site 751585000507 G-X-G motif; other site 751585000508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585000509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585000510 active site 751585000511 phosphorylation site [posttranslational modification] 751585000512 intermolecular recognition site; other site 751585000513 dimerization interface [polypeptide binding]; other site 751585000514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585000515 DNA binding site [nucleotide binding] 751585000516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585000517 non-specific DNA binding site [nucleotide binding]; other site 751585000518 salt bridge; other site 751585000519 sequence-specific DNA binding site [nucleotide binding]; other site 751585000520 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 751585000521 CoenzymeA binding site [chemical binding]; other site 751585000522 subunit interaction site [polypeptide binding]; other site 751585000523 PHB binding site; other site 751585000524 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 751585000525 Na binding site [ion binding]; other site 751585000526 Protein of unknown function (DUF997); Region: DUF997; cl01614 751585000527 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 751585000528 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 751585000529 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 751585000530 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 751585000531 tetramer interface [polypeptide binding]; other site 751585000532 active site 751585000533 amidophosphoribosyltransferase; Provisional; Region: PRK05793 751585000534 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 751585000535 active site 751585000536 tetramer interface [polypeptide binding]; other site 751585000537 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 751585000538 active site 751585000539 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 751585000540 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 751585000541 active site 751585000542 substrate binding site [chemical binding]; other site 751585000543 metal binding site [ion binding]; metal-binding site 751585000544 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 751585000545 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 751585000546 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 751585000547 Ligand Binding Site [chemical binding]; other site 751585000548 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 751585000549 GTP cyclohydrolase I; Provisional; Region: PLN03044 751585000550 active site 751585000551 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 751585000552 active site 751585000553 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 751585000554 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 751585000555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585000556 catalytic residue [active] 751585000557 3D domain; Region: 3D; cl01439 751585000558 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 751585000559 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 751585000560 FMN binding site [chemical binding]; other site 751585000561 active site 751585000562 catalytic residues [active] 751585000563 substrate binding site [chemical binding]; other site 751585000564 pantothenate kinase; Reviewed; Region: PRK13318 751585000565 dihydrodipicolinate reductase; Provisional; Region: PRK00048 751585000566 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 751585000567 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 751585000568 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 751585000569 dihydrodipicolinate synthase; Region: dapA; TIGR00674 751585000570 dimer interface [polypeptide binding]; other site 751585000571 active site 751585000572 catalytic residue [active] 751585000573 single-stranded DNA-binding protein; Provisional; Region: PRK05813 751585000574 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 751585000575 dimer interface [polypeptide binding]; other site 751585000576 ssDNA binding site [nucleotide binding]; other site 751585000577 tetramer (dimer of dimers) interface [polypeptide binding]; other site 751585000578 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 751585000579 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 751585000580 active site 751585000581 PHP Thumb interface [polypeptide binding]; other site 751585000582 metal binding site [ion binding]; metal-binding site 751585000583 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 751585000584 generic binding surface II; other site 751585000585 generic binding surface I; other site 751585000586 AAA domain; Region: AAA_14; pfam13173 751585000587 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 751585000588 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 751585000589 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 751585000590 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 751585000591 regulatory protein interface [polypeptide binding]; other site 751585000592 regulatory phosphorylation site [posttranslational modification]; other site 751585000593 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 751585000594 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 751585000595 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 751585000596 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 751585000597 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 751585000598 FAD binding domain; Region: FAD_binding_4; pfam01565 751585000599 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 751585000600 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 751585000601 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 751585000602 nucleotide binding site [chemical binding]; other site 751585000603 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 751585000604 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 751585000605 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 751585000606 Hpr binding site; other site 751585000607 active site 751585000608 homohexamer subunit interaction site [polypeptide binding]; other site 751585000609 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 751585000610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 751585000611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 751585000612 DNA binding residues [nucleotide binding] 751585000613 Protein of unknown function, DUF624; Region: DUF624; pfam04854 751585000614 Protein of unknown function, DUF624; Region: DUF624; cl02369 751585000615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585000616 dimer interface [polypeptide binding]; other site 751585000617 conserved gate region; other site 751585000618 putative PBP binding loops; other site 751585000619 ABC-ATPase subunit interface; other site 751585000620 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 751585000621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000622 Walker A/P-loop; other site 751585000623 ATP binding site [chemical binding]; other site 751585000624 Q-loop/lid; other site 751585000625 ABC transporter signature motif; other site 751585000626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585000627 ABC transporter; Region: ABC_tran_2; pfam12848 751585000628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585000629 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 751585000630 Trp repressor protein; Region: Trp_repressor; cl17266 751585000631 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 751585000632 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 751585000633 active site 751585000634 Na/Ca binding site [ion binding]; other site 751585000635 catalytic site [active] 751585000636 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 751585000637 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 751585000638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585000639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585000640 homodimer interface [polypeptide binding]; other site 751585000641 catalytic residue [active] 751585000642 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 751585000643 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 751585000644 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 751585000645 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 751585000646 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 751585000647 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 751585000648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000649 Walker A/P-loop; other site 751585000650 ATP binding site [chemical binding]; other site 751585000651 Q-loop/lid; other site 751585000652 ABC transporter signature motif; other site 751585000653 Walker B; other site 751585000654 D-loop; other site 751585000655 H-loop/switch region; other site 751585000656 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 751585000657 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 751585000658 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 751585000659 dimer interface [polypeptide binding]; other site 751585000660 ssDNA binding site [nucleotide binding]; other site 751585000661 tetramer (dimer of dimers) interface [polypeptide binding]; other site 751585000662 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 751585000663 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 751585000664 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 751585000665 active site 751585000666 substrate-binding site [chemical binding]; other site 751585000667 metal-binding site [ion binding] 751585000668 ATP binding site [chemical binding]; other site 751585000669 Ion transport protein; Region: Ion_trans; pfam00520 751585000670 Ion channel; Region: Ion_trans_2; pfam07885 751585000671 TrkA-C domain; Region: TrkA_C; pfam02080 751585000672 OmpA family; Region: OmpA; pfam00691 751585000673 ligand binding site [chemical binding]; other site 751585000674 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 751585000675 Na binding site [ion binding]; other site 751585000676 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 751585000677 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 751585000678 acyl-activating enzyme (AAE) consensus motif; other site 751585000679 AMP binding site [chemical binding]; other site 751585000680 active site 751585000681 CoA binding site [chemical binding]; other site 751585000682 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 751585000683 thiS-thiF/thiG interaction site; other site 751585000684 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 751585000685 ThiS interaction site; other site 751585000686 putative active site [active] 751585000687 tetramer interface [polypeptide binding]; other site 751585000688 Radical SAM superfamily; Region: Radical_SAM; pfam04055 751585000689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585000690 FeS/SAM binding site; other site 751585000691 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 751585000692 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 751585000693 thiamine phosphate binding site [chemical binding]; other site 751585000694 active site 751585000695 pyrophosphate binding site [ion binding]; other site 751585000696 Predicted transcriptional regulators [Transcription]; Region: COG1695 751585000697 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 751585000698 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 751585000699 AAA domain; Region: AAA_14; pfam13173 751585000700 phenylalanine ammonia-lyase; Region: phe_am_lyase; TIGR01226 751585000701 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 751585000702 Transposase; Region: DEDD_Tnp_IS110; pfam01548 751585000703 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 751585000704 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 751585000705 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 751585000706 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 751585000707 Walker A motif; other site 751585000708 ATP binding site [chemical binding]; other site 751585000709 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 751585000710 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 751585000711 catalytic residues [active] 751585000712 catalytic nucleophile [active] 751585000713 CHC2 zinc finger; Region: zf-CHC2; cl17510 751585000714 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 751585000715 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 751585000716 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 751585000717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 751585000718 Coenzyme A binding pocket [chemical binding]; other site 751585000719 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 751585000720 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 751585000721 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 751585000722 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 751585000723 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 751585000724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 751585000725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 751585000726 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 751585000727 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 751585000728 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585000729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585000730 non-specific DNA binding site [nucleotide binding]; other site 751585000731 salt bridge; other site 751585000732 sequence-specific DNA binding site [nucleotide binding]; other site 751585000733 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 751585000734 putative protofilament interface [polypeptide binding]; other site 751585000735 nucleotide binding site [chemical binding]; other site 751585000736 Cna protein B-type domain; Region: Cna_B; pfam05738 751585000737 Cna protein B-type domain; Region: Cna_B; pfam05738 751585000738 Cna protein B-type domain; Region: Cna_B; pfam05738 751585000739 Cna protein B-type domain; Region: Cna_B; pfam05738 751585000740 Cna protein B-type domain; Region: Cna_B; pfam05738 751585000741 Cna protein B-type domain; Region: Cna_B; pfam05738 751585000742 Cna protein B-type domain; Region: Cna_B; pfam05738 751585000743 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 751585000744 dimerization interface [polypeptide binding]; other site 751585000745 putative active site pocket [active] 751585000746 putative catalytic residue [active] 751585000747 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 751585000748 active site 751585000749 catalytic site [active] 751585000750 S-adenosylmethionine synthetase; Validated; Region: PRK05250 751585000751 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 751585000752 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 751585000753 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 751585000754 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 751585000755 Toprim-like; Region: Toprim_2; pfam13155 751585000756 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 751585000757 DNA methylase; Region: N6_N4_Mtase; pfam01555 751585000758 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 751585000759 T-DNA border endonuclease VirD1; Region: VirD1; cl17530 751585000760 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 751585000761 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 751585000762 phosphoribosylanthranilate isomerase; Region: PLN02363 751585000763 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 751585000764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585000765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585000766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000767 Walker A/P-loop; other site 751585000768 ATP binding site [chemical binding]; other site 751585000769 Q-loop/lid; other site 751585000770 ABC transporter signature motif; other site 751585000771 Walker B; other site 751585000772 D-loop; other site 751585000773 H-loop/switch region; other site 751585000774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585000775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585000776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000777 Walker A/P-loop; other site 751585000778 ATP binding site [chemical binding]; other site 751585000779 Q-loop/lid; other site 751585000780 ABC transporter signature motif; other site 751585000781 Walker B; other site 751585000782 D-loop; other site 751585000783 H-loop/switch region; other site 751585000784 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 751585000785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 751585000786 DNA binding residues [nucleotide binding] 751585000787 RNA polymerase sigma factor; Provisional; Region: PRK11924 751585000788 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 751585000789 MobA/MobL family; Region: MobA_MobL; pfam03389 751585000790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 751585000791 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 751585000792 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 751585000793 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 751585000794 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 751585000795 hypothetical protein; Validated; Region: PRK08116 751585000796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585000797 Walker A motif; other site 751585000798 ATP binding site [chemical binding]; other site 751585000799 Walker B motif; other site 751585000800 arginine finger; other site 751585000801 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 751585000802 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 751585000803 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 751585000804 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 751585000805 AAA domain; Region: AAA_25; pfam13481 751585000806 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 751585000807 ATP binding site [chemical binding]; other site 751585000808 Walker A motif; other site 751585000809 Walker B motif; other site 751585000810 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 751585000811 65 kDa invariant surface glycoprotein; Provisional; Region: PTZ00208 751585000812 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 751585000813 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 751585000814 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 751585000815 putative catalytic residues [active] 751585000816 catalytic nucleophile [active] 751585000817 Recombinase; Region: Recombinase; pfam07508 751585000818 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 751585000819 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 751585000820 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 751585000821 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 751585000822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 751585000823 DNA binding residues [nucleotide binding] 751585000824 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 751585000825 PrgI family protein; Region: PrgI; pfam12666 751585000826 AAA-like domain; Region: AAA_10; pfam12846 751585000827 Domain of unknown function DUF87; Region: DUF87; pfam01935 751585000828 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 751585000829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585000830 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 751585000831 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 751585000832 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 751585000833 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 751585000834 Walker A/P-loop; other site 751585000835 ATP binding site [chemical binding]; other site 751585000836 Q-loop/lid; other site 751585000837 ABC transporter signature motif; other site 751585000838 Walker B; other site 751585000839 D-loop; other site 751585000840 H-loop/switch region; other site 751585000841 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 751585000842 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 751585000843 Walker A/P-loop; other site 751585000844 ATP binding site [chemical binding]; other site 751585000845 Q-loop/lid; other site 751585000846 ABC transporter signature motif; other site 751585000847 Walker B; other site 751585000848 D-loop; other site 751585000849 H-loop/switch region; other site 751585000850 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585000851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585000852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000853 Walker A/P-loop; other site 751585000854 ATP binding site [chemical binding]; other site 751585000855 Q-loop/lid; other site 751585000856 ABC transporter signature motif; other site 751585000857 Walker B; other site 751585000858 D-loop; other site 751585000859 H-loop/switch region; other site 751585000860 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585000861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585000862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585000863 Walker A/P-loop; other site 751585000864 ATP binding site [chemical binding]; other site 751585000865 Q-loop/lid; other site 751585000866 ABC transporter signature motif; other site 751585000867 Walker B; other site 751585000868 D-loop; other site 751585000869 H-loop/switch region; other site 751585000870 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585000871 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585000872 Walker A/P-loop; other site 751585000873 ATP binding site [chemical binding]; other site 751585000874 Q-loop/lid; other site 751585000875 ABC transporter signature motif; other site 751585000876 Walker B; other site 751585000877 D-loop; other site 751585000878 H-loop/switch region; other site 751585000879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585000880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585000881 active site 751585000882 phosphorylation site [posttranslational modification] 751585000883 intermolecular recognition site; other site 751585000884 dimerization interface [polypeptide binding]; other site 751585000885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585000886 DNA binding site [nucleotide binding] 751585000887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585000888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585000889 ATP binding site [chemical binding]; other site 751585000890 Mg2+ binding site [ion binding]; other site 751585000891 G-X-G motif; other site 751585000892 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 751585000893 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 751585000894 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 751585000895 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 751585000896 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 751585000897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 751585000898 active site 751585000899 DNA binding site [nucleotide binding] 751585000900 Int/Topo IB signature motif; other site 751585000901 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 751585000902 DNA binding site [nucleotide binding] 751585000903 Int/Topo IB signature motif; other site 751585000904 active site 751585000905 catalytic residues [active] 751585000906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 751585000907 active site 751585000908 DNA binding site [nucleotide binding] 751585000909 Int/Topo IB signature motif; other site 751585000910 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 751585000911 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 751585000912 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 751585000913 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 751585000914 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 751585000915 nudix motif; other site 751585000916 Colicin V production protein; Region: Colicin_V; pfam02674 751585000917 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 751585000918 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 751585000919 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 751585000920 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 751585000921 FOG: CBS domain [General function prediction only]; Region: COG0517 751585000922 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 751585000923 2-isopropylmalate synthase; Validated; Region: PRK03739 751585000924 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 751585000925 active site 751585000926 catalytic residues [active] 751585000927 metal binding site [ion binding]; metal-binding site 751585000928 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 751585000929 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 751585000930 ligand binding site [chemical binding]; other site 751585000931 active site 751585000932 UGI interface [polypeptide binding]; other site 751585000933 catalytic site [active] 751585000934 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 751585000935 catalytic core [active] 751585000936 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 751585000937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585000938 Zn2+ binding site [ion binding]; other site 751585000939 Mg2+ binding site [ion binding]; other site 751585000940 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 751585000941 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 751585000942 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 751585000943 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 751585000944 RNA binding site [nucleotide binding]; other site 751585000945 CotJB protein; Region: CotJB; pfam12652 751585000946 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 751585000947 dimanganese center [ion binding]; other site 751585000948 EamA-like transporter family; Region: EamA; pfam00892 751585000949 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 751585000950 EamA-like transporter family; Region: EamA; pfam00892 751585000951 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 751585000952 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 751585000953 active site 751585000954 metal binding site [ion binding]; metal-binding site 751585000955 DNA binding site [nucleotide binding] 751585000956 CTP synthetase; Validated; Region: pyrG; PRK05380 751585000957 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 751585000958 Catalytic site [active] 751585000959 active site 751585000960 UTP binding site [chemical binding]; other site 751585000961 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 751585000962 active site 751585000963 putative oxyanion hole; other site 751585000964 catalytic triad [active] 751585000965 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 751585000966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 751585000967 dimerization interface [polypeptide binding]; other site 751585000968 putative DNA binding site [nucleotide binding]; other site 751585000969 putative Zn2+ binding site [ion binding]; other site 751585000970 Uncharacterized conserved protein [Function unknown]; Region: COG2155 751585000971 CAAX protease self-immunity; Region: Abi; pfam02517 751585000972 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 751585000973 homotrimer interaction site [polypeptide binding]; other site 751585000974 putative active site [active] 751585000975 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 751585000976 S1 domain; Region: S1_2; pfam13509 751585000977 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 751585000978 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 751585000979 active site 751585000980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 751585000981 active site 751585000982 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 751585000983 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 751585000984 active site 751585000985 metal binding site [ion binding]; metal-binding site 751585000986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585000987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585000988 metal binding site [ion binding]; metal-binding site 751585000989 active site 751585000990 I-site; other site 751585000991 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 751585000992 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 751585000993 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 751585000994 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 751585000995 dimer interface [polypeptide binding]; other site 751585000996 PYR/PP interface [polypeptide binding]; other site 751585000997 TPP binding site [chemical binding]; other site 751585000998 substrate binding site [chemical binding]; other site 751585000999 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 751585001000 TPP-binding site; other site 751585001001 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 751585001002 von Willebrand factor; Region: vWF_A; pfam12450 751585001003 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 751585001004 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 751585001005 metal ion-dependent adhesion site (MIDAS); other site 751585001006 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 751585001007 Src Homology 3 domain superfamily; Region: SH3; cl17036 751585001008 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 751585001009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 751585001010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 751585001011 DNA binding residues [nucleotide binding] 751585001012 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 751585001013 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 751585001014 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 751585001015 synthetase active site [active] 751585001016 NTP binding site [chemical binding]; other site 751585001017 metal binding site [ion binding]; metal-binding site 751585001018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 751585001019 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 751585001020 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 751585001021 active site 751585001022 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 751585001023 serine/threonine transporter SstT; Provisional; Region: PRK13628 751585001024 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 751585001025 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 751585001026 substrate binding site [chemical binding]; other site 751585001027 THF binding site; other site 751585001028 zinc-binding site [ion binding]; other site 751585001029 LabA_like proteins; Region: LabA_like; cd06167 751585001030 putative metal binding site [ion binding]; other site 751585001031 HTH-like domain; Region: HTH_21; pfam13276 751585001032 Integrase core domain; Region: rve; pfam00665 751585001033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585001034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585001035 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 751585001036 Walker A/P-loop; other site 751585001037 ATP binding site [chemical binding]; other site 751585001038 Q-loop/lid; other site 751585001039 ABC transporter signature motif; other site 751585001040 Walker B; other site 751585001041 D-loop; other site 751585001042 H-loop/switch region; other site 751585001043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585001044 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 751585001045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585001046 Walker A/P-loop; other site 751585001047 ATP binding site [chemical binding]; other site 751585001048 Q-loop/lid; other site 751585001049 ABC transporter signature motif; other site 751585001050 Walker B; other site 751585001051 D-loop; other site 751585001052 H-loop/switch region; other site 751585001053 FeoA domain; Region: FeoA; cl00838 751585001054 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 751585001055 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 751585001056 homodimer interface [polypeptide binding]; other site 751585001057 substrate-cofactor binding pocket; other site 751585001058 catalytic residue [active] 751585001059 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 751585001060 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 751585001061 transmembrane helices; other site 751585001062 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 751585001063 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 751585001064 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 751585001065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 751585001066 nucleotide binding site [chemical binding]; other site 751585001067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 751585001068 active site 751585001069 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 751585001070 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 751585001071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 751585001072 active site 751585001073 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 751585001074 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 751585001075 putative substrate binding site 2 [chemical binding]; other site 751585001076 putative substrate binding site 1 [chemical binding]; other site 751585001077 Na binding site 1 [ion binding]; other site 751585001078 Na2 binding site [ion binding]; other site 751585001079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585001080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585001081 dimer interface [polypeptide binding]; other site 751585001082 phosphorylation site [posttranslational modification] 751585001083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585001084 ATP binding site [chemical binding]; other site 751585001085 Mg2+ binding site [ion binding]; other site 751585001086 G-X-G motif; other site 751585001087 Response regulator receiver domain; Region: Response_reg; pfam00072 751585001088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585001089 active site 751585001090 phosphorylation site [posttranslational modification] 751585001091 intermolecular recognition site; other site 751585001092 dimerization interface [polypeptide binding]; other site 751585001093 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; Region: RPB9; COG1594 751585001094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585001095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585001096 non-specific DNA binding site [nucleotide binding]; other site 751585001097 salt bridge; other site 751585001098 sequence-specific DNA binding site [nucleotide binding]; other site 751585001099 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 751585001100 AAA domain; Region: AAA_12; pfam13087 751585001101 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 751585001102 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 751585001103 phosphopeptide binding site; other site 751585001104 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 751585001105 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 751585001106 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 751585001107 Proteins of 100 residues with WXG; Region: WXG100; cl02005 751585001108 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 751585001109 mRNA/rRNA interface [nucleotide binding]; other site 751585001110 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 751585001111 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 751585001112 23S rRNA interface [nucleotide binding]; other site 751585001113 L7/L12 interface [polypeptide binding]; other site 751585001114 putative thiostrepton binding site; other site 751585001115 L25 interface [polypeptide binding]; other site 751585001116 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 751585001117 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 751585001118 putative homodimer interface [polypeptide binding]; other site 751585001119 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 751585001120 heterodimer interface [polypeptide binding]; other site 751585001121 homodimer interface [polypeptide binding]; other site 751585001122 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 751585001123 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 751585001124 SseB protein; Region: SseB; cl06279 751585001125 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 751585001126 glutamate racemase; Provisional; Region: PRK00865 751585001127 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 751585001128 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 751585001129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 751585001130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 751585001131 putative substrate translocation pore; other site 751585001132 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 751585001133 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 751585001134 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 751585001135 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 751585001136 active site 751585001137 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 751585001138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585001139 dimer interface [polypeptide binding]; other site 751585001140 conserved gate region; other site 751585001141 putative PBP binding loops; other site 751585001142 ABC-ATPase subunit interface; other site 751585001143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585001144 dimer interface [polypeptide binding]; other site 751585001145 conserved gate region; other site 751585001146 putative PBP binding loops; other site 751585001147 ABC-ATPase subunit interface; other site 751585001148 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 751585001149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585001150 Walker A/P-loop; other site 751585001151 ATP binding site [chemical binding]; other site 751585001152 Q-loop/lid; other site 751585001153 ABC transporter signature motif; other site 751585001154 Walker B; other site 751585001155 D-loop; other site 751585001156 H-loop/switch region; other site 751585001157 TOBE domain; Region: TOBE_2; pfam08402 751585001158 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 751585001159 Nitrogen regulatory protein P-II; Region: P-II; smart00938 751585001160 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 751585001161 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 751585001162 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 751585001163 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 751585001164 dimer interface [polypeptide binding]; other site 751585001165 active site 751585001166 metal binding site [ion binding]; metal-binding site 751585001167 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 751585001168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 751585001169 hydroxyglutarate oxidase; Provisional; Region: PRK11728 751585001170 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 751585001171 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 751585001172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 751585001173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 751585001174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 751585001175 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 751585001176 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 751585001177 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 751585001178 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 751585001179 DNA binding residues [nucleotide binding] 751585001180 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 751585001181 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 751585001182 putative metal binding site [ion binding]; other site 751585001183 xanthine permease; Region: pbuX; TIGR03173 751585001184 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 751585001185 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 751585001186 active site 751585001187 putative substrate binding pocket [chemical binding]; other site 751585001188 HIRAN domain; Region: HIRAN; pfam08797 751585001189 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 751585001190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 751585001191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585001192 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 751585001193 Walker B motif; other site 751585001194 Homoserine O-succinyltransferase; Region: HTS; pfam04204 751585001195 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 751585001196 proposed active site lysine [active] 751585001197 conserved cys residue [active] 751585001198 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 751585001199 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 751585001200 nucleotide binding pocket [chemical binding]; other site 751585001201 K-X-D-G motif; other site 751585001202 catalytic site [active] 751585001203 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 751585001204 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 751585001205 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 751585001206 Dimer interface [polypeptide binding]; other site 751585001207 BRCT sequence motif; other site 751585001208 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 751585001209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 751585001210 RNA binding surface [nucleotide binding]; other site 751585001211 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 751585001212 active site 751585001213 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 751585001214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 751585001215 putative DNA binding site [nucleotide binding]; other site 751585001216 putative Zn2+ binding site [ion binding]; other site 751585001217 AsnC family; Region: AsnC_trans_reg; pfam01037 751585001218 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 751585001219 Sulfate transporter family; Region: Sulfate_transp; pfam00916 751585001220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585001221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585001222 ATP binding site [chemical binding]; other site 751585001223 Mg2+ binding site [ion binding]; other site 751585001224 G-X-G motif; other site 751585001225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585001226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585001227 active site 751585001228 phosphorylation site [posttranslational modification] 751585001229 intermolecular recognition site; other site 751585001230 dimerization interface [polypeptide binding]; other site 751585001231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585001232 DNA binding site [nucleotide binding] 751585001233 translation elongation factor Ts; Region: tsf; TIGR00116 751585001234 Elongation factor TS; Region: EF_TS; pfam00889 751585001235 Elongation factor TS; Region: EF_TS; pfam00889 751585001236 Elongation factor TS; Region: EF_TS; pfam00889 751585001237 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 751585001238 rRNA interaction site [nucleotide binding]; other site 751585001239 S8 interaction site; other site 751585001240 putative laminin-1 binding site; other site 751585001241 YceG-like family; Region: YceG; pfam02618 751585001242 CodY GAF-like domain; Region: CodY; pfam06018 751585001243 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 751585001244 DNA topoisomerase I; Validated; Region: PRK05582 751585001245 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 751585001246 active site 751585001247 interdomain interaction site; other site 751585001248 putative metal-binding site [ion binding]; other site 751585001249 nucleotide binding site [chemical binding]; other site 751585001250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 751585001251 domain I; other site 751585001252 DNA binding groove [nucleotide binding] 751585001253 phosphate binding site [ion binding]; other site 751585001254 domain II; other site 751585001255 domain III; other site 751585001256 nucleotide binding site [chemical binding]; other site 751585001257 catalytic site [active] 751585001258 domain IV; other site 751585001259 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 751585001260 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 751585001261 DNA protecting protein DprA; Region: dprA; TIGR00732 751585001262 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 751585001263 RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127 751585001264 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 751585001265 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 751585001266 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 751585001267 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 751585001268 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 751585001269 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 751585001270 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 751585001271 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 751585001272 Walker A/P-loop; other site 751585001273 ATP binding site [chemical binding]; other site 751585001274 Q-loop/lid; other site 751585001275 ABC transporter signature motif; other site 751585001276 Walker B; other site 751585001277 D-loop; other site 751585001278 H-loop/switch region; other site 751585001279 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 751585001280 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 751585001281 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 751585001282 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 751585001283 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 751585001284 mechanosensitive channel MscS; Provisional; Region: PRK10334 751585001285 Mechanosensitive ion channel; Region: MS_channel; pfam00924 751585001286 glycogen branching enzyme; Provisional; Region: PRK12313 751585001287 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 751585001288 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 751585001289 active site 751585001290 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 751585001291 Uncharacterized conserved protein [Function unknown]; Region: COG4198 751585001292 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 751585001293 AAA domain; Region: AAA_33; pfam13671 751585001294 AAA domain; Region: AAA_17; pfam13207 751585001295 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 751585001296 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 751585001297 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 751585001298 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 751585001299 putative ligand binding site [chemical binding]; other site 751585001300 putative NAD binding site [chemical binding]; other site 751585001301 putative catalytic site [active] 751585001302 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 751585001303 L-serine binding site [chemical binding]; other site 751585001304 ACT domain interface; other site 751585001305 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 751585001306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 751585001307 catalytic residue [active] 751585001308 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 751585001309 6-phosphogluconate dehydratase; Region: edd; TIGR01196 751585001310 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 751585001311 tartrate dehydrogenase; Region: TTC; TIGR02089 751585001312 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 751585001313 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 751585001314 substrate binding site [chemical binding]; other site 751585001315 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 751585001316 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 751585001317 substrate binding site [chemical binding]; other site 751585001318 ligand binding site [chemical binding]; other site 751585001319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 751585001320 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 751585001321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 751585001322 dimerization interface [polypeptide binding]; other site 751585001323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 751585001324 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 751585001325 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 751585001326 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 751585001327 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 751585001328 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 751585001329 dimerization interface [polypeptide binding]; other site 751585001330 ATP binding site [chemical binding]; other site 751585001331 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 751585001332 dimerization interface [polypeptide binding]; other site 751585001333 ATP binding site [chemical binding]; other site 751585001334 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 751585001335 putative active site [active] 751585001336 catalytic triad [active] 751585001337 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 751585001338 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 751585001339 putative active site [active] 751585001340 Zn binding site [ion binding]; other site 751585001341 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 751585001342 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 751585001343 putative active site [active] 751585001344 Zn binding site [ion binding]; other site 751585001345 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 751585001346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585001347 active site 751585001348 phosphorylation site [posttranslational modification] 751585001349 intermolecular recognition site; other site 751585001350 dimerization interface [polypeptide binding]; other site 751585001351 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 751585001352 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 751585001353 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 751585001354 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 751585001355 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 751585001356 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 751585001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585001358 Walker A/P-loop; other site 751585001359 ATP binding site [chemical binding]; other site 751585001360 Q-loop/lid; other site 751585001361 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 751585001362 ABC transporter signature motif; other site 751585001363 Walker B; other site 751585001364 D-loop; other site 751585001365 H-loop/switch region; other site 751585001366 Arginine repressor [Transcription]; Region: ArgR; COG1438 751585001367 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 751585001368 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 751585001369 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 751585001370 ATP-NAD kinase; Region: NAD_kinase; pfam01513 751585001371 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 751585001372 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 751585001373 TPP-binding site; other site 751585001374 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 751585001375 PYR/PP interface [polypeptide binding]; other site 751585001376 dimer interface [polypeptide binding]; other site 751585001377 TPP binding site [chemical binding]; other site 751585001378 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 751585001379 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 751585001380 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 751585001381 substrate binding pocket [chemical binding]; other site 751585001382 chain length determination region; other site 751585001383 substrate-Mg2+ binding site; other site 751585001384 catalytic residues [active] 751585001385 aspartate-rich region 1; other site 751585001386 active site lid residues [active] 751585001387 aspartate-rich region 2; other site 751585001388 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 751585001389 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 751585001390 Asp23 family; Region: Asp23; pfam03780 751585001391 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 751585001392 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 751585001393 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 751585001394 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 751585001395 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 751585001396 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 751585001397 elongation factor P; Validated; Region: PRK00529 751585001398 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 751585001399 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 751585001400 RNA binding site [nucleotide binding]; other site 751585001401 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 751585001402 RNA binding site [nucleotide binding]; other site 751585001403 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 751585001404 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 751585001405 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 751585001406 active site 751585001407 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 751585001408 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 751585001409 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 751585001410 shikimate binding site; other site 751585001411 NAD(P) binding site [chemical binding]; other site 751585001412 shikimate kinase; Reviewed; Region: aroK; PRK00131 751585001413 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 751585001414 ADP binding site [chemical binding]; other site 751585001415 magnesium binding site [ion binding]; other site 751585001416 putative shikimate binding site; other site 751585001417 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 751585001418 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 751585001419 dimer interface [polypeptide binding]; other site 751585001420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585001421 catalytic residue [active] 751585001422 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 751585001423 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 751585001424 substrate binding [chemical binding]; other site 751585001425 active site 751585001426 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 751585001427 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 751585001428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585001429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585001430 non-specific DNA binding site [nucleotide binding]; other site 751585001431 salt bridge; other site 751585001432 sequence-specific DNA binding site [nucleotide binding]; other site 751585001433 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 751585001434 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 751585001435 dinuclear metal binding motif [ion binding]; other site 751585001436 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 751585001437 Walker A/P-loop; other site 751585001438 ATP binding site [chemical binding]; other site 751585001439 Q-loop/lid; other site 751585001440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585001441 D-loop; other site 751585001442 H-loop/switch region; other site 751585001443 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 751585001444 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 751585001445 ligand binding site [chemical binding]; other site 751585001446 flexible hinge region; other site 751585001447 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 751585001448 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 751585001449 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585001450 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 751585001451 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 751585001452 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 751585001453 Walker A/P-loop; other site 751585001454 ATP binding site [chemical binding]; other site 751585001455 Q-loop/lid; other site 751585001456 ABC transporter signature motif; other site 751585001457 Walker B; other site 751585001458 D-loop; other site 751585001459 H-loop/switch region; other site 751585001460 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 751585001461 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 751585001462 maltose O-acetyltransferase; Provisional; Region: PRK10092 751585001463 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 751585001464 active site 751585001465 substrate binding site [chemical binding]; other site 751585001466 trimer interface [polypeptide binding]; other site 751585001467 CoA binding site [chemical binding]; other site 751585001468 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 751585001469 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 751585001470 dimerization interface 3.5A [polypeptide binding]; other site 751585001471 active site 751585001472 Uncharacterized conserved protein [Function unknown]; Region: COG2966 751585001473 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 751585001474 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 751585001475 ATP binding site [chemical binding]; other site 751585001476 active site 751585001477 substrate binding site [chemical binding]; other site 751585001478 NAD synthetase; Reviewed; Region: nadE; PRK02628 751585001479 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 751585001480 multimer interface [polypeptide binding]; other site 751585001481 active site 751585001482 catalytic triad [active] 751585001483 protein interface 1 [polypeptide binding]; other site 751585001484 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 751585001485 homodimer interface [polypeptide binding]; other site 751585001486 NAD binding pocket [chemical binding]; other site 751585001487 ATP binding pocket [chemical binding]; other site 751585001488 Mg binding site [ion binding]; other site 751585001489 active-site loop [active] 751585001490 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 751585001491 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 751585001492 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 751585001493 active site 751585001494 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 751585001495 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 751585001496 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 751585001497 DNA binding residues [nucleotide binding] 751585001498 dimerization interface [polypeptide binding]; other site 751585001499 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585001500 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585001501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585001502 Walker A/P-loop; other site 751585001503 ATP binding site [chemical binding]; other site 751585001504 Q-loop/lid; other site 751585001505 ABC transporter signature motif; other site 751585001506 Walker B; other site 751585001507 D-loop; other site 751585001508 H-loop/switch region; other site 751585001509 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585001510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585001511 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 751585001512 Walker A/P-loop; other site 751585001513 ATP binding site [chemical binding]; other site 751585001514 Q-loop/lid; other site 751585001515 ABC transporter signature motif; other site 751585001516 Walker B; other site 751585001517 D-loop; other site 751585001518 H-loop/switch region; other site 751585001519 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 751585001520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585001521 S-adenosylmethionine binding site [chemical binding]; other site 751585001522 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 751585001523 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 751585001524 dimer interface [polypeptide binding]; other site 751585001525 pyridoxal binding site [chemical binding]; other site 751585001526 ATP binding site [chemical binding]; other site 751585001527 TIGR04076 family protein; Region: TIGR04076 751585001528 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585001529 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 751585001530 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 751585001531 active site 751585001532 oxyanion hole [active] 751585001533 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 751585001534 active site 751585001535 catalytic triad [active] 751585001536 oxyanion hole [active] 751585001537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585001538 non-specific DNA binding site [nucleotide binding]; other site 751585001539 cyanate hydratase; Validated; Region: PRK02866 751585001540 salt bridge; other site 751585001541 sequence-specific DNA binding site [nucleotide binding]; other site 751585001542 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cl07841 751585001543 oligomer interface [polypeptide binding]; other site 751585001544 active site 751585001545 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585001546 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 751585001547 Uncharacterized conserved protein [Function unknown]; Region: COG1284 751585001548 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 751585001549 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 751585001550 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 751585001551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585001552 FeS/SAM binding site; other site 751585001553 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 751585001554 dimer interface [polypeptide binding]; other site 751585001555 pyridoxal binding site [chemical binding]; other site 751585001556 ATP binding site [chemical binding]; other site 751585001557 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585001558 metal binding site [ion binding]; metal-binding site 751585001559 active site 751585001560 I-site; other site 751585001561 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 751585001562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585001563 Zn2+ binding site [ion binding]; other site 751585001564 Mg2+ binding site [ion binding]; other site 751585001565 PAS domain; Region: PAS_9; pfam13426 751585001566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 751585001567 putative active site [active] 751585001568 heme pocket [chemical binding]; other site 751585001569 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585001570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585001571 metal binding site [ion binding]; metal-binding site 751585001572 active site 751585001573 I-site; other site 751585001574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 751585001575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 751585001576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585001577 active site 751585001578 phosphorylation site [posttranslational modification] 751585001579 intermolecular recognition site; other site 751585001580 dimerization interface [polypeptide binding]; other site 751585001581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 751585001582 DNA binding residues [nucleotide binding] 751585001583 dimerization interface [polypeptide binding]; other site 751585001584 TM2 domain; Region: TM2; pfam05154 751585001585 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 751585001586 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585001587 Interdomain contacts; other site 751585001588 Transglutaminase/protease-like homologues; Region: TGc; smart00460 751585001589 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 751585001590 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 751585001591 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 751585001592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585001593 active site 751585001594 phosphorylation site [posttranslational modification] 751585001595 intermolecular recognition site; other site 751585001596 dimerization interface [polypeptide binding]; other site 751585001597 LytTr DNA-binding domain; Region: LytTR; pfam04397 751585001598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585001599 ATP binding site [chemical binding]; other site 751585001600 Mg2+ binding site [ion binding]; other site 751585001601 G-X-G motif; other site 751585001602 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 751585001603 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 751585001604 non-specific DNA binding site [nucleotide binding]; other site 751585001605 salt bridge; other site 751585001606 sequence-specific DNA binding site [nucleotide binding]; other site 751585001607 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 751585001608 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 751585001609 Peptidase family M23; Region: Peptidase_M23; pfam01551 751585001610 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 751585001611 NlpC/P60 family; Region: NLPC_P60; pfam00877 751585001612 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 751585001613 DNA topoisomerase III; Provisional; Region: PRK07726 751585001614 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 751585001615 active site 751585001616 putative interdomain interaction site [polypeptide binding]; other site 751585001617 putative metal-binding site [ion binding]; other site 751585001618 putative nucleotide binding site [chemical binding]; other site 751585001619 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 751585001620 domain I; other site 751585001621 DNA binding groove [nucleotide binding] 751585001622 phosphate binding site [ion binding]; other site 751585001623 domain II; other site 751585001624 domain III; other site 751585001625 nucleotide binding site [chemical binding]; other site 751585001626 catalytic site [active] 751585001627 domain IV; other site 751585001628 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 751585001629 RES domain; Region: RES; pfam08808 751585001630 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 751585001631 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 751585001632 putative catalytic residues [active] 751585001633 catalytic nucleophile [active] 751585001634 Recombinase; Region: Recombinase; pfam07508 751585001635 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 751585001636 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 751585001637 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 751585001638 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 751585001639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585001640 non-specific DNA binding site [nucleotide binding]; other site 751585001641 salt bridge; other site 751585001642 sequence-specific DNA binding site [nucleotide binding]; other site 751585001643 AAA domain; Region: AAA_25; pfam13481 751585001644 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 751585001645 Walker A motif; other site 751585001646 ATP binding site [chemical binding]; other site 751585001647 Walker B motif; other site 751585001648 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 751585001649 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 751585001650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 751585001651 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 751585001652 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 751585001653 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 751585001654 G1 box; other site 751585001655 putative GEF interaction site [polypeptide binding]; other site 751585001656 GTP/Mg2+ binding site [chemical binding]; other site 751585001657 Switch I region; other site 751585001658 G2 box; other site 751585001659 G3 box; other site 751585001660 Switch II region; other site 751585001661 G4 box; other site 751585001662 G5 box; other site 751585001663 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 751585001664 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 751585001665 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 751585001666 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 751585001667 AAA domain; Region: AAA_25; pfam13481 751585001668 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 751585001669 Walker A motif; other site 751585001670 ATP binding site [chemical binding]; other site 751585001671 Walker B motif; other site 751585001672 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 751585001673 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 751585001674 ParB-like nuclease domain; Region: ParBc; pfam02195 751585001675 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 751585001676 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 751585001677 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 751585001678 putative catalytic residues [active] 751585001679 catalytic nucleophile [active] 751585001680 Recombinase; Region: Recombinase; pfam07508 751585001681 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 751585001682 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 751585001683 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 751585001684 Domain of unknown function (DUF4319); Region: DUF4319; pfam14203 751585001685 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 751585001686 Predicted transcriptional regulators [Transcription]; Region: COG1733 751585001687 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 751585001688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 751585001689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 751585001690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 751585001691 dimerization interface [polypeptide binding]; other site 751585001692 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 751585001693 Low molecular weight phosphatase family; Region: LMWPc; cd00115 751585001694 active site 751585001695 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 751585001696 putative deacylase active site [active] 751585001697 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 751585001698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585001699 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 751585001700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585001701 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 751585001702 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 751585001703 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 751585001704 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 751585001705 conserved cys residue [active] 751585001706 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 751585001707 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 751585001708 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 751585001709 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 751585001710 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 751585001711 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 751585001712 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 751585001713 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 751585001714 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 751585001715 Domain of unknown function (DUF368); Region: DUF368; cl00893 751585001716 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 751585001717 catalytic residues [active] 751585001718 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 751585001719 dimer interface [polypeptide binding]; other site 751585001720 Citrate synthase; Region: Citrate_synt; pfam00285 751585001721 active site 751585001722 citrylCoA binding site [chemical binding]; other site 751585001723 oxalacetate/citrate binding site [chemical binding]; other site 751585001724 coenzyme A binding site [chemical binding]; other site 751585001725 catalytic triad [active] 751585001726 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 751585001727 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 751585001728 minor groove reading motif; other site 751585001729 helix-hairpin-helix signature motif; other site 751585001730 substrate binding pocket [chemical binding]; other site 751585001731 active site 751585001732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 751585001733 active site 751585001734 uracil-xanthine permease; Region: ncs2; TIGR00801 751585001735 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 751585001736 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 751585001737 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 751585001738 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 751585001739 Peptidase family M23; Region: Peptidase_M23; pfam01551 751585001740 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 751585001741 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 751585001742 active site 751585001743 catalytic triad [active] 751585001744 oxyanion hole [active] 751585001745 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 751585001746 EamA-like transporter family; Region: EamA; cl17759 751585001747 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 751585001748 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 751585001749 catalytic core [active] 751585001750 FtsX-like permease family; Region: FtsX; pfam02687 751585001751 FtsX-like permease family; Region: FtsX; pfam02687 751585001752 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 751585001753 Part of AAA domain; Region: AAA_19; pfam13245 751585001754 Family description; Region: UvrD_C_2; pfam13538 751585001755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 751585001756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 751585001757 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 751585001758 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 751585001759 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 751585001760 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 751585001761 Melibiase; Region: Melibiase; pfam02065 751585001762 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 751585001763 metal binding site 2 [ion binding]; metal-binding site 751585001764 putative DNA binding helix; other site 751585001765 metal binding site 1 [ion binding]; metal-binding site 751585001766 dimer interface [polypeptide binding]; other site 751585001767 structural Zn2+ binding site [ion binding]; other site 751585001768 L-asparaginase II; Region: Asparaginase_II; pfam06089 751585001769 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 751585001770 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 751585001771 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 751585001772 ligand binding site; other site 751585001773 oligomer interface; other site 751585001774 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 751585001775 dimer interface [polypeptide binding]; other site 751585001776 N-terminal domain interface [polypeptide binding]; other site 751585001777 sulfate 1 binding site; other site 751585001778 regulatory protein SpoVG; Reviewed; Region: PRK13259 751585001779 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 751585001780 Substrate binding site; other site 751585001781 Mg++ binding site; other site 751585001782 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 751585001783 putative active site [active] 751585001784 catalytic residue [active] 751585001785 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 751585001786 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 751585001787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 751585001788 ATP binding site [chemical binding]; other site 751585001789 putative Mg++ binding site [ion binding]; other site 751585001790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 751585001791 nucleotide binding region [chemical binding]; other site 751585001792 ATP-binding site [chemical binding]; other site 751585001793 TRCF domain; Region: TRCF; pfam03461 751585001794 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 751585001795 trimer interface [polypeptide binding]; other site 751585001796 active site 751585001797 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 751585001798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585001799 FeS/SAM binding site; other site 751585001800 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 751585001801 ATP cone domain; Region: ATP-cone; pfam03477 751585001802 Class III ribonucleotide reductase; Region: RNR_III; cd01675 751585001803 effector binding site; other site 751585001804 active site 751585001805 Zn binding site [ion binding]; other site 751585001806 glycine loop; other site 751585001807 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 751585001808 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 751585001809 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 751585001810 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 751585001811 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585001812 Interdomain contacts; other site 751585001813 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 751585001814 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 751585001815 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 751585001816 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 751585001817 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 751585001818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 751585001819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585001820 Walker A/P-loop; other site 751585001821 ATP binding site [chemical binding]; other site 751585001822 Q-loop/lid; other site 751585001823 ABC transporter signature motif; other site 751585001824 Walker B; other site 751585001825 D-loop; other site 751585001826 H-loop/switch region; other site 751585001827 MFS/sugar transport protein; Region: MFS_2; pfam13347 751585001828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 751585001829 putative substrate translocation pore; other site 751585001830 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 751585001831 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 751585001832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585001833 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585001834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585001835 non-specific DNA binding site [nucleotide binding]; other site 751585001836 salt bridge; other site 751585001837 sequence-specific DNA binding site [nucleotide binding]; other site 751585001838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 751585001839 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 751585001840 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 751585001841 Predicted transcriptional regulators [Transcription]; Region: COG1725 751585001842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 751585001843 DNA-binding site [nucleotide binding]; DNA binding site 751585001844 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 751585001845 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 751585001846 Walker A/P-loop; other site 751585001847 ATP binding site [chemical binding]; other site 751585001848 Q-loop/lid; other site 751585001849 ABC transporter signature motif; other site 751585001850 Walker B; other site 751585001851 D-loop; other site 751585001852 H-loop/switch region; other site 751585001853 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 751585001854 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 751585001855 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 751585001856 Predicted membrane protein [Function unknown]; Region: COG2364 751585001857 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 751585001858 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585001859 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 751585001860 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 751585001861 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 751585001862 serine O-acetyltransferase; Region: cysE; TIGR01172 751585001863 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 751585001864 trimer interface [polypeptide binding]; other site 751585001865 active site 751585001866 substrate binding site [chemical binding]; other site 751585001867 CoA binding site [chemical binding]; other site 751585001868 6-phosphofructokinase; Provisional; Region: PRK03202 751585001869 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 751585001870 active site 751585001871 ADP/pyrophosphate binding site [chemical binding]; other site 751585001872 dimerization interface [polypeptide binding]; other site 751585001873 allosteric effector site; other site 751585001874 fructose-1,6-bisphosphate binding site; other site 751585001875 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 751585001876 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 751585001877 active site 751585001878 HIGH motif; other site 751585001879 dimer interface [polypeptide binding]; other site 751585001880 KMSKS motif; other site 751585001881 Predicted membrane protein [Function unknown]; Region: COG1511 751585001882 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 751585001883 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 751585001884 Predicted membrane protein [Function unknown]; Region: COG1511 751585001885 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 751585001886 Predicted membrane protein [Function unknown]; Region: COG1511 751585001887 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 751585001888 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 751585001889 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 751585001890 putative catalytic cysteine [active] 751585001891 trehalose synthase; Region: treS_nterm; TIGR02456 751585001892 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 751585001893 active site 751585001894 catalytic site [active] 751585001895 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 751585001896 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 751585001897 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 751585001898 active site 751585001899 metal binding site [ion binding]; metal-binding site 751585001900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 751585001901 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 751585001902 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 751585001903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 751585001904 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 751585001905 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 751585001906 enolase; Provisional; Region: eno; PRK00077 751585001907 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 751585001908 dimer interface [polypeptide binding]; other site 751585001909 metal binding site [ion binding]; metal-binding site 751585001910 substrate binding pocket [chemical binding]; other site 751585001911 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 751585001912 HSP70 interaction site [polypeptide binding]; other site 751585001913 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 751585001914 substrate binding site [polypeptide binding]; other site 751585001915 dimer interface [polypeptide binding]; other site 751585001916 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 751585001917 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 751585001918 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 751585001919 active site 751585001920 catalytic site [active] 751585001921 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 751585001922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585001923 active site 751585001924 motif I; other site 751585001925 motif II; other site 751585001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 751585001927 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 751585001928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585001929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585001930 dimer interface [polypeptide binding]; other site 751585001931 phosphorylation site [posttranslational modification] 751585001932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585001933 ATP binding site [chemical binding]; other site 751585001934 Mg2+ binding site [ion binding]; other site 751585001935 G-X-G motif; other site 751585001936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585001937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585001938 active site 751585001939 phosphorylation site [posttranslational modification] 751585001940 intermolecular recognition site; other site 751585001941 dimerization interface [polypeptide binding]; other site 751585001942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585001943 DNA binding site [nucleotide binding] 751585001944 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 751585001945 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 751585001946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 751585001947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585001948 dimer interface [polypeptide binding]; other site 751585001949 conserved gate region; other site 751585001950 putative PBP binding loops; other site 751585001951 ABC-ATPase subunit interface; other site 751585001952 acyl-activating enzyme; Provisional; Region: PLN03051 751585001953 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585001954 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585001955 Walker A/P-loop; other site 751585001956 ATP binding site [chemical binding]; other site 751585001957 Q-loop/lid; other site 751585001958 ABC transporter signature motif; other site 751585001959 Walker B; other site 751585001960 D-loop; other site 751585001961 H-loop/switch region; other site 751585001962 FtsX-like permease family; Region: FtsX; pfam02687 751585001963 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 751585001964 FtsX-like permease family; Region: FtsX; pfam02687 751585001965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585001966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585001967 active site 751585001968 phosphorylation site [posttranslational modification] 751585001969 intermolecular recognition site; other site 751585001970 dimerization interface [polypeptide binding]; other site 751585001971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585001972 DNA binding site [nucleotide binding] 751585001973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585001974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585001975 dimer interface [polypeptide binding]; other site 751585001976 phosphorylation site [posttranslational modification] 751585001977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585001978 ATP binding site [chemical binding]; other site 751585001979 Mg2+ binding site [ion binding]; other site 751585001980 G-X-G motif; other site 751585001981 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 751585001982 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 751585001983 active site 751585001984 DNA binding site [nucleotide binding] 751585001985 Int/Topo IB signature motif; other site 751585001986 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 751585001987 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 751585001988 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 751585001989 active site 751585001990 metal binding site [ion binding]; metal-binding site 751585001991 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 751585001992 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 751585001993 putative dimer interface [polypeptide binding]; other site 751585001994 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 751585001995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 751585001996 DNA-binding site [nucleotide binding]; DNA binding site 751585001997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585001998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585001999 homodimer interface [polypeptide binding]; other site 751585002000 catalytic residue [active] 751585002001 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 751585002002 PBP superfamily domain; Region: PBP_like_2; cl17296 751585002003 PBP superfamily domain; Region: PBP_like_2; cl17296 751585002004 Glutamine amidotransferase class-I; Region: GATase; pfam00117 751585002005 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 751585002006 glutamine binding [chemical binding]; other site 751585002007 catalytic triad [active] 751585002008 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 751585002009 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 751585002010 chorismate binding enzyme; Region: Chorismate_bind; cl10555 751585002011 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 751585002012 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 751585002013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585002014 catalytic residue [active] 751585002015 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 751585002016 homodimer interaction site [polypeptide binding]; other site 751585002017 cofactor binding site; other site 751585002018 PBP superfamily domain; Region: PBP_like_2; cl17296 751585002019 PBP superfamily domain; Region: PBP_like_2; cl17296 751585002020 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 751585002021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585002022 dimer interface [polypeptide binding]; other site 751585002023 conserved gate region; other site 751585002024 putative PBP binding loops; other site 751585002025 ABC-ATPase subunit interface; other site 751585002026 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 751585002027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585002028 dimer interface [polypeptide binding]; other site 751585002029 conserved gate region; other site 751585002030 putative PBP binding loops; other site 751585002031 ABC-ATPase subunit interface; other site 751585002032 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 751585002033 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 751585002034 Walker A/P-loop; other site 751585002035 ATP binding site [chemical binding]; other site 751585002036 Q-loop/lid; other site 751585002037 ABC transporter signature motif; other site 751585002038 Walker B; other site 751585002039 D-loop; other site 751585002040 H-loop/switch region; other site 751585002041 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 751585002042 PhoU domain; Region: PhoU; pfam01895 751585002043 PhoU domain; Region: PhoU; pfam01895 751585002044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585002045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585002046 active site 751585002047 phosphorylation site [posttranslational modification] 751585002048 intermolecular recognition site; other site 751585002049 dimerization interface [polypeptide binding]; other site 751585002050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585002051 DNA binding site [nucleotide binding] 751585002052 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 751585002053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585002054 dimer interface [polypeptide binding]; other site 751585002055 phosphorylation site [posttranslational modification] 751585002056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585002057 ATP binding site [chemical binding]; other site 751585002058 Mg2+ binding site [ion binding]; other site 751585002059 G-X-G motif; other site 751585002060 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 751585002061 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 751585002062 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 751585002063 Citrate synthase; Region: Citrate_synt; pfam00285 751585002064 oxalacetate binding site [chemical binding]; other site 751585002065 citrylCoA binding site [chemical binding]; other site 751585002066 coenzyme A binding site [chemical binding]; other site 751585002067 catalytic triad [active] 751585002068 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 751585002069 putative deacylase active site [active] 751585002070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 751585002071 Methyltransferase domain; Region: Methyltransf_32; pfam13679 751585002072 Methyltransferase domain; Region: Methyltransf_31; pfam13847 751585002073 LabA_like proteins; Region: LabA_like; cd06167 751585002074 putative metal binding site [ion binding]; other site 751585002075 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 751585002076 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 751585002077 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 751585002078 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 751585002079 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 751585002080 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 751585002081 protein-rRNA interface [nucleotide binding]; other site 751585002082 putative translocon binding site; other site 751585002083 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 751585002084 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 751585002085 RNA binding site [nucleotide binding]; other site 751585002086 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 751585002087 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 751585002088 23S rRNA interface [nucleotide binding]; other site 751585002089 L5 interface [polypeptide binding]; other site 751585002090 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 751585002091 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 751585002092 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 751585002093 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 751585002094 23S rRNA binding site [nucleotide binding]; other site 751585002095 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 751585002096 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 751585002097 SecY translocase; Region: SecY; pfam00344 751585002098 adenylate kinase; Reviewed; Region: adk; PRK00279 751585002099 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 751585002100 AMP-binding site [chemical binding]; other site 751585002101 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 751585002102 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 751585002103 active site 751585002104 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 751585002105 rRNA binding site [nucleotide binding]; other site 751585002106 predicted 30S ribosome binding site; other site 751585002107 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 751585002108 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 751585002109 30S ribosomal protein S13; Region: bact_S13; TIGR03631 751585002110 30S ribosomal protein S11; Validated; Region: PRK05309 751585002111 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 751585002112 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 751585002113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 751585002114 RNA binding surface [nucleotide binding]; other site 751585002115 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 751585002116 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 751585002117 alphaNTD - beta interaction site [polypeptide binding]; other site 751585002118 alphaNTD homodimer interface [polypeptide binding]; other site 751585002119 alphaNTD - beta' interaction site [polypeptide binding]; other site 751585002120 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 751585002121 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 751585002122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585002123 D-loop; other site 751585002124 H-loop/switch region; other site 751585002125 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 751585002126 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 751585002127 Walker A/P-loop; other site 751585002128 ATP binding site [chemical binding]; other site 751585002129 Q-loop/lid; other site 751585002130 ABC transporter signature motif; other site 751585002131 Walker B; other site 751585002132 D-loop; other site 751585002133 H-loop/switch region; other site 751585002134 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 751585002135 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 751585002136 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 751585002137 dimerization interface 3.5A [polypeptide binding]; other site 751585002138 active site 751585002139 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 751585002140 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 751585002141 putative active site [active] 751585002142 metal binding site [ion binding]; metal-binding site 751585002143 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 751585002144 23S rRNA interface [nucleotide binding]; other site 751585002145 L3 interface [polypeptide binding]; other site 751585002146 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 751585002147 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 751585002148 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 751585002149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 751585002150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 751585002151 substrate binding pocket [chemical binding]; other site 751585002152 membrane-bound complex binding site; other site 751585002153 hinge residues; other site 751585002154 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 751585002155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585002156 dimer interface [polypeptide binding]; other site 751585002157 conserved gate region; other site 751585002158 putative PBP binding loops; other site 751585002159 ABC-ATPase subunit interface; other site 751585002160 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 751585002161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585002162 Walker A/P-loop; other site 751585002163 ATP binding site [chemical binding]; other site 751585002164 Q-loop/lid; other site 751585002165 ABC transporter signature motif; other site 751585002166 Walker B; other site 751585002167 D-loop; other site 751585002168 H-loop/switch region; other site 751585002169 Cupin domain; Region: Cupin_2; cl17218 751585002170 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 751585002171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585002172 dimer interface [polypeptide binding]; other site 751585002173 conserved gate region; other site 751585002174 putative PBP binding loops; other site 751585002175 ABC-ATPase subunit interface; other site 751585002176 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 751585002177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585002178 dimer interface [polypeptide binding]; other site 751585002179 conserved gate region; other site 751585002180 putative PBP binding loops; other site 751585002181 ABC-ATPase subunit interface; other site 751585002182 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 751585002183 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 751585002184 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 751585002185 amidophosphoribosyltransferase; Provisional; Region: PRK08525 751585002186 active site 751585002187 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 751585002188 active site 751585002189 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 751585002190 active site residue [active] 751585002191 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 751585002192 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 751585002193 Ligand Binding Site [chemical binding]; other site 751585002194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585002195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585002196 active site 751585002197 phosphorylation site [posttranslational modification] 751585002198 intermolecular recognition site; other site 751585002199 dimerization interface [polypeptide binding]; other site 751585002200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585002201 DNA binding site [nucleotide binding] 751585002202 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 751585002203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585002204 dimer interface [polypeptide binding]; other site 751585002205 phosphorylation site [posttranslational modification] 751585002206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585002207 ATP binding site [chemical binding]; other site 751585002208 Mg2+ binding site [ion binding]; other site 751585002209 G-X-G motif; other site 751585002210 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 751585002211 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 751585002212 transmembrane helices; other site 751585002213 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 751585002214 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 751585002215 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 751585002216 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 751585002217 acyl-activating enzyme (AAE) consensus motif; other site 751585002218 AMP binding site [chemical binding]; other site 751585002219 active site 751585002220 CoA binding site [chemical binding]; other site 751585002221 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 751585002222 metal-binding site [ion binding] 751585002223 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 751585002224 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 751585002225 Soluble P-type ATPase [General function prediction only]; Region: COG4087 751585002226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 751585002227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 751585002228 putative DNA binding site [nucleotide binding]; other site 751585002229 Predicted transcriptional regulators [Transcription]; Region: COG1725 751585002230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 751585002231 DNA-binding site [nucleotide binding]; DNA binding site 751585002232 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 751585002233 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 751585002234 Walker A/P-loop; other site 751585002235 ATP binding site [chemical binding]; other site 751585002236 Q-loop/lid; other site 751585002237 ABC transporter signature motif; other site 751585002238 Walker B; other site 751585002239 D-loop; other site 751585002240 H-loop/switch region; other site 751585002241 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 751585002242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585002243 motif II; other site 751585002244 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 751585002245 FAD binding site [chemical binding]; other site 751585002246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 751585002247 Yqey-like protein; Region: YqeY; cl17540 751585002248 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 751585002249 Ligand binding site; other site 751585002250 Putative Catalytic site; other site 751585002251 DXD motif; other site 751585002252 Cysteine-rich small domain; Region: zf-like; pfam04071 751585002253 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 751585002254 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 751585002255 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585002256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 751585002257 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 751585002258 Coenzyme A binding pocket [chemical binding]; other site 751585002259 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 751585002260 putative deacylase active site [active] 751585002261 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 751585002262 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 751585002263 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 751585002264 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 751585002265 Coenzyme A binding pocket [chemical binding]; other site 751585002266 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 751585002267 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 751585002268 Uncharacterized conserved protein [Function unknown]; Region: COG1434 751585002269 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 751585002270 putative active site [active] 751585002271 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 751585002272 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 751585002273 PYR/PP interface [polypeptide binding]; other site 751585002274 dimer interface [polypeptide binding]; other site 751585002275 TPP binding site [chemical binding]; other site 751585002276 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 751585002277 biotin synthase; Region: bioB; TIGR00433 751585002278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585002279 FeS/SAM binding site; other site 751585002280 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 751585002281 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 751585002282 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 751585002283 active site 751585002284 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 751585002285 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 751585002286 active site 751585002287 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585002288 Interdomain contacts; other site 751585002289 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 751585002290 Cytokine receptor motif; other site 751585002291 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585002292 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585002293 Interdomain contacts; other site 751585002294 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585002295 Interdomain contacts; other site 751585002296 Bacterial SH3 domain homologues; Region: SH3b; smart00287 751585002297 pyruvate kinase; Provisional; Region: PRK06354 751585002298 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 751585002299 domain interfaces; other site 751585002300 active site 751585002301 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 751585002302 Bacterial SH3 domain; Region: SH3_3; pfam08239 751585002303 Bacterial SH3 domain; Region: SH3_3; pfam08239 751585002304 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 751585002305 NlpC/P60 family; Region: NLPC_P60; pfam00877 751585002306 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 751585002307 DEAD/DEAH box helicase; Region: DEAD; pfam00270 751585002308 ATP binding site [chemical binding]; other site 751585002309 putative Mg++ binding site [ion binding]; other site 751585002310 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 751585002311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 751585002312 nucleotide binding region [chemical binding]; other site 751585002313 ATP-binding site [chemical binding]; other site 751585002314 SEC-C motif; Region: SEC-C; pfam02810 751585002315 homoserine dehydrogenase; Provisional; Region: PRK06349 751585002316 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 751585002317 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 751585002318 aspartate kinase; Reviewed; Region: PRK06635 751585002319 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 751585002320 putative nucleotide binding site [chemical binding]; other site 751585002321 putative catalytic residues [active] 751585002322 putative Mg ion binding site [ion binding]; other site 751585002323 putative aspartate binding site [chemical binding]; other site 751585002324 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 751585002325 putative allosteric regulatory site; other site 751585002326 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 751585002327 putative allosteric regulatory residue; other site 751585002328 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 751585002329 catalytic motif [active] 751585002330 Zn binding site [ion binding]; other site 751585002331 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 751585002332 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 751585002333 Glycoprotease family; Region: Peptidase_M22; pfam00814 751585002334 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 751585002335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 751585002336 Coenzyme A binding pocket [chemical binding]; other site 751585002337 ribonuclease Z; Region: RNase_Z; TIGR02651 751585002338 UGMP family protein; Validated; Region: PRK09604 751585002339 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 751585002340 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 751585002341 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 751585002342 substrate binding site; other site 751585002343 dimer interface; other site 751585002344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 751585002345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 751585002346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 751585002347 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 751585002348 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 751585002349 active site 751585002350 HIGH motif; other site 751585002351 dimer interface [polypeptide binding]; other site 751585002352 KMSKS motif; other site 751585002353 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 751585002354 RNA binding surface [nucleotide binding]; other site 751585002355 O-Antigen ligase; Region: Wzy_C; pfam04932 751585002356 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 751585002357 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 751585002358 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 751585002359 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 751585002360 putative active site [active] 751585002361 catalytic site [active] 751585002362 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 751585002363 putative active site [active] 751585002364 catalytic site [active] 751585002365 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 751585002366 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 751585002367 metal-binding site [ion binding] 751585002368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 751585002369 Soluble P-type ATPase [General function prediction only]; Region: COG4087 751585002370 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 751585002371 metal-binding site [ion binding] 751585002372 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 751585002373 putative homodimer interface [polypeptide binding]; other site 751585002374 putative homotetramer interface [polypeptide binding]; other site 751585002375 putative allosteric switch controlling residues; other site 751585002376 putative metal binding site [ion binding]; other site 751585002377 putative homodimer-homodimer interface [polypeptide binding]; other site 751585002378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585002379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585002380 Walker A/P-loop; other site 751585002381 ATP binding site [chemical binding]; other site 751585002382 Q-loop/lid; other site 751585002383 ABC transporter signature motif; other site 751585002384 Walker B; other site 751585002385 D-loop; other site 751585002386 H-loop/switch region; other site 751585002387 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 751585002388 FtsX-like permease family; Region: FtsX; pfam02687 751585002389 FtsX-like permease family; Region: FtsX; pfam02687 751585002390 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 751585002391 HlyD family secretion protein; Region: HlyD_3; pfam13437 751585002392 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 751585002393 23S rRNA binding site [nucleotide binding]; other site 751585002394 L21 binding site [polypeptide binding]; other site 751585002395 L13 binding site [polypeptide binding]; other site 751585002396 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 751585002397 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 751585002398 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 751585002399 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 751585002400 polyphosphate kinase; Provisional; Region: PRK05443 751585002401 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 751585002402 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 751585002403 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 751585002404 putative domain interface [polypeptide binding]; other site 751585002405 putative active site [active] 751585002406 catalytic site [active] 751585002407 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 751585002408 putative domain interface [polypeptide binding]; other site 751585002409 putative active site [active] 751585002410 catalytic site [active] 751585002411 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 751585002412 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 751585002413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585002414 Zn2+ binding site [ion binding]; other site 751585002415 Mg2+ binding site [ion binding]; other site 751585002416 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 751585002417 Prephenate dehydratase; Region: PDT; pfam00800 751585002418 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 751585002419 putative L-Phe binding site [chemical binding]; other site 751585002420 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 751585002421 homooctamer interface [polypeptide binding]; other site 751585002422 active site 751585002423 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 751585002424 catalytic center binding site [active] 751585002425 ATP binding site [chemical binding]; other site 751585002426 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 751585002427 dihydropteroate synthase; Region: DHPS; TIGR01496 751585002428 substrate binding pocket [chemical binding]; other site 751585002429 dimer interface [polypeptide binding]; other site 751585002430 inhibitor binding site; inhibition site 751585002431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585002432 Zn2+ binding site [ion binding]; other site 751585002433 Mg2+ binding site [ion binding]; other site 751585002434 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 751585002435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 751585002436 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 751585002437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585002438 motif II; other site 751585002439 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 751585002440 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 751585002441 Domain of unknown function DUF; Region: DUF204; pfam02659 751585002442 Domain of unknown function DUF; Region: DUF204; pfam02659 751585002443 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 751585002444 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 751585002445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585002446 Walker A motif; other site 751585002447 ATP binding site [chemical binding]; other site 751585002448 Walker B motif; other site 751585002449 arginine finger; other site 751585002450 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 751585002451 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 751585002452 Nitrogen regulatory protein P-II; Region: P-II; smart00938 751585002453 ammonium transporter; Region: amt; TIGR00836 751585002454 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 751585002455 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 751585002456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 751585002457 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 751585002458 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 751585002459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 751585002460 DEAD_2; Region: DEAD_2; pfam06733 751585002461 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 751585002462 DJ-1 family protein; Region: not_thiJ; TIGR01383 751585002463 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 751585002464 conserved cys residue [active] 751585002465 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 751585002466 putative active site [active] 751585002467 putative metal binding residues [ion binding]; other site 751585002468 signature motif; other site 751585002469 putative dimer interface [polypeptide binding]; other site 751585002470 putative phosphate binding site [ion binding]; other site 751585002471 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 751585002472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585002473 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 751585002474 active site 751585002475 motif I; other site 751585002476 motif II; other site 751585002477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 751585002478 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 751585002479 homopentamer interface [polypeptide binding]; other site 751585002480 active site 751585002481 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 751585002482 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 751585002483 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 751585002484 dimerization interface [polypeptide binding]; other site 751585002485 active site 751585002486 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 751585002487 Lumazine binding domain; Region: Lum_binding; pfam00677 751585002488 Lumazine binding domain; Region: Lum_binding; pfam00677 751585002489 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 751585002490 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 751585002491 catalytic motif [active] 751585002492 Zn binding site [ion binding]; other site 751585002493 RibD C-terminal domain; Region: RibD_C; cl17279 751585002494 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 751585002495 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 751585002496 metal ion-dependent adhesion site (MIDAS); other site 751585002497 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 751585002498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585002499 active site 751585002500 motif I; other site 751585002501 motif II; other site 751585002502 histidyl-tRNA synthetase; Region: hisS; TIGR00442 751585002503 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 751585002504 dimer interface [polypeptide binding]; other site 751585002505 motif 1; other site 751585002506 active site 751585002507 motif 2; other site 751585002508 motif 3; other site 751585002509 MutS domain III; Region: MutS_III; cl17822 751585002510 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 751585002511 Walker A/P-loop; other site 751585002512 ATP binding site [chemical binding]; other site 751585002513 Q-loop/lid; other site 751585002514 ABC transporter signature motif; other site 751585002515 Walker B; other site 751585002516 D-loop; other site 751585002517 H-loop/switch region; other site 751585002518 Repair protein; Region: Repair_PSII; cl01535 751585002519 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 751585002520 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 751585002521 HIGH motif; other site 751585002522 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 751585002523 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585002524 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585002525 active site 751585002526 KMSKS motif; other site 751585002527 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 751585002528 tRNA binding surface [nucleotide binding]; other site 751585002529 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 751585002530 nudix motif; other site 751585002531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585002532 S-adenosylmethionine binding site [chemical binding]; other site 751585002533 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 751585002534 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 751585002535 dimerization interface [polypeptide binding]; other site 751585002536 domain crossover interface; other site 751585002537 redox-dependent activation switch; other site 751585002538 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 751585002539 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 751585002540 G1 box; other site 751585002541 putative GEF interaction site [polypeptide binding]; other site 751585002542 GTP/Mg2+ binding site [chemical binding]; other site 751585002543 Switch I region; other site 751585002544 G2 box; other site 751585002545 G3 box; other site 751585002546 Switch II region; other site 751585002547 G4 box; other site 751585002548 G5 box; other site 751585002549 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 751585002550 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 751585002551 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 751585002552 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 751585002553 FtsX-like permease family; Region: FtsX; pfam02687 751585002554 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585002555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585002556 non-specific DNA binding site [nucleotide binding]; other site 751585002557 salt bridge; other site 751585002558 sequence-specific DNA binding site [nucleotide binding]; other site 751585002559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585002560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585002561 active site 751585002562 phosphorylation site [posttranslational modification] 751585002563 intermolecular recognition site; other site 751585002564 dimerization interface [polypeptide binding]; other site 751585002565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585002566 DNA binding site [nucleotide binding] 751585002567 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 751585002568 GAD domain; Region: GAD; pfam02938 751585002569 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 751585002570 active site 751585002571 motif 3; other site 751585002572 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 751585002573 dimer interface [polypeptide binding]; other site 751585002574 anticodon binding site; other site 751585002575 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 751585002576 motif 1; other site 751585002577 dimer interface [polypeptide binding]; other site 751585002578 motif 2; other site 751585002579 hypothetical protein; Provisional; Region: PRK11770 751585002580 Domain of unknown function (DUF307); Region: DUF307; pfam03733 751585002581 Domain of unknown function (DUF307); Region: DUF307; pfam03733 751585002582 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 751585002583 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 751585002584 FMN binding site [chemical binding]; other site 751585002585 active site 751585002586 catalytic residues [active] 751585002587 substrate binding site [chemical binding]; other site 751585002588 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 751585002589 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 751585002590 active site 751585002591 PHP-associated; Region: PHP_C; pfam13263 751585002592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 751585002593 Coenzyme A binding pocket [chemical binding]; other site 751585002594 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 751585002595 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 751585002596 Catalytic site [active] 751585002597 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 751585002598 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 751585002599 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 751585002600 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 751585002601 active site 751585002602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 751585002603 metal-binding site [ion binding] 751585002604 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 751585002605 metal binding site 2 [ion binding]; metal-binding site 751585002606 putative DNA binding helix; other site 751585002607 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585002608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585002609 active site 751585002610 phosphorylation site [posttranslational modification] 751585002611 intermolecular recognition site; other site 751585002612 dimerization interface [polypeptide binding]; other site 751585002613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585002614 DNA binding site [nucleotide binding] 751585002615 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 751585002616 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 751585002617 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 751585002618 Cl binding site [ion binding]; other site 751585002619 oligomer interface [polypeptide binding]; other site 751585002620 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 751585002621 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 751585002622 Na binding site [ion binding]; other site 751585002623 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 751585002624 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 751585002625 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 751585002626 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 751585002627 Part of AAA domain; Region: AAA_19; pfam13245 751585002628 Family description; Region: UvrD_C_2; pfam13538 751585002629 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 751585002630 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 751585002631 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 751585002632 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 751585002633 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 751585002634 Peptidase C26; Region: Peptidase_C26; pfam07722 751585002635 conserved cys residue [active] 751585002636 hypothetical protein; Provisional; Region: PRK05849 751585002637 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 751585002638 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 751585002639 Nitroreductase family; Region: Nitroreductase; pfam00881 751585002640 FMN binding site [chemical binding]; other site 751585002641 dimer interface [polypeptide binding]; other site 751585002642 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 751585002643 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 751585002644 active site 751585002645 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 751585002646 Family of unknown function (DUF633); Region: DUF633; pfam04816 751585002647 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 751585002648 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585002649 Zn2+ binding site [ion binding]; other site 751585002650 Mg2+ binding site [ion binding]; other site 751585002651 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 751585002652 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 751585002653 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 751585002654 GIY-YIG motif/motif A; other site 751585002655 active site 751585002656 catalytic site [active] 751585002657 putative DNA binding site [nucleotide binding]; other site 751585002658 metal binding site [ion binding]; metal-binding site 751585002659 UvrB/uvrC motif; Region: UVR; pfam02151 751585002660 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 751585002661 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 751585002662 active site 751585002663 catalytic site [active] 751585002664 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 751585002665 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 751585002666 dimer interface [polypeptide binding]; other site 751585002667 active site 751585002668 glycine-pyridoxal phosphate binding site [chemical binding]; other site 751585002669 folate binding site [chemical binding]; other site 751585002670 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 751585002671 Clp amino terminal domain; Region: Clp_N; pfam02861 751585002672 Clp amino terminal domain; Region: Clp_N; pfam02861 751585002673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585002674 Walker A motif; other site 751585002675 ATP binding site [chemical binding]; other site 751585002676 Walker B motif; other site 751585002677 arginine finger; other site 751585002678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585002679 Walker A motif; other site 751585002680 ATP binding site [chemical binding]; other site 751585002681 Walker B motif; other site 751585002682 arginine finger; other site 751585002683 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 751585002684 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 751585002685 beta-galactosidase; Region: BGL; TIGR03356 751585002686 NAD-dependent deacetylase; Provisional; Region: PRK00481 751585002687 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 751585002688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 751585002689 TPR repeat; Region: TPR_11; pfam13414 751585002690 binding surface 751585002691 von Willebrand factor type A domain; Region: VWA_2; pfam13519 751585002692 metal ion-dependent adhesion site (MIDAS); other site 751585002693 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 751585002694 metal ion-dependent adhesion site (MIDAS); other site 751585002695 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 751585002696 Protein of unknown function DUF58; Region: DUF58; pfam01882 751585002697 MoxR-like ATPases [General function prediction only]; Region: COG0714 751585002698 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 751585002699 Walker A motif; other site 751585002700 ATP binding site [chemical binding]; other site 751585002701 Walker B motif; other site 751585002702 arginine finger; other site 751585002703 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 751585002704 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 751585002705 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 751585002706 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 751585002707 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 751585002708 putative metal binding site [ion binding]; other site 751585002709 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 751585002710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585002711 Walker A/P-loop; other site 751585002712 ATP binding site [chemical binding]; other site 751585002713 Q-loop/lid; other site 751585002714 ABC transporter signature motif; other site 751585002715 Walker B; other site 751585002716 D-loop; other site 751585002717 H-loop/switch region; other site 751585002718 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 751585002719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585002720 active site 751585002721 phosphorylation site [posttranslational modification] 751585002722 intermolecular recognition site; other site 751585002723 dimerization interface [polypeptide binding]; other site 751585002724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585002725 DNA binding site [nucleotide binding] 751585002726 Helix-turn-helix domain; Region: HTH_17; pfam12728 751585002727 C-terminal peptidase (prc); Region: prc; TIGR00225 751585002728 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 751585002729 protein binding site [polypeptide binding]; other site 751585002730 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 751585002731 Catalytic dyad [active] 751585002732 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 751585002733 Peptidase family M23; Region: Peptidase_M23; pfam01551 751585002734 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 751585002735 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 751585002736 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 751585002737 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 751585002738 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 751585002739 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 751585002740 Walker A/P-loop; other site 751585002741 ATP binding site [chemical binding]; other site 751585002742 Q-loop/lid; other site 751585002743 ABC transporter signature motif; other site 751585002744 Walker B; other site 751585002745 D-loop; other site 751585002746 H-loop/switch region; other site 751585002747 TOBE domain; Region: TOBE; pfam03459 751585002748 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 751585002749 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 751585002750 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 751585002751 catalytic core [active] 751585002752 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 751585002753 glutamate dehydrogenase; Provisional; Region: PRK09414 751585002754 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 751585002755 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 751585002756 NAD(P) binding pocket [chemical binding]; other site 751585002757 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 751585002758 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 751585002759 AsnC family; Region: AsnC_trans_reg; pfam01037 751585002760 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 751585002761 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 751585002762 putative oxidoreductase; Provisional; Region: PRK12831 751585002763 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 751585002764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 751585002765 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 751585002766 dimerization domain swap beta strand [polypeptide binding]; other site 751585002767 regulatory protein interface [polypeptide binding]; other site 751585002768 active site 751585002769 regulatory phosphorylation site [posttranslational modification]; other site 751585002770 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 751585002771 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 751585002772 active site 751585002773 phosphorylation site [posttranslational modification] 751585002774 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 751585002775 active site 751585002776 P-loop; other site 751585002777 phosphorylation site [posttranslational modification] 751585002778 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 751585002779 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 751585002780 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 751585002781 putative substrate binding site [chemical binding]; other site 751585002782 putative ATP binding site [chemical binding]; other site 751585002783 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 751585002784 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 751585002785 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 751585002786 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 751585002787 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 751585002788 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 751585002789 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 751585002790 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 751585002791 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 751585002792 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 751585002793 metal ion-dependent adhesion site (MIDAS); other site 751585002794 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 751585002795 ADP-ribose binding site [chemical binding]; other site 751585002796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585002797 non-specific DNA binding site [nucleotide binding]; other site 751585002798 salt bridge; other site 751585002799 sequence-specific DNA binding site [nucleotide binding]; other site 751585002800 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 751585002801 heterotetramer interface [polypeptide binding]; other site 751585002802 active site pocket [active] 751585002803 cleavage site 751585002804 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 751585002805 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585002806 active site 751585002807 HIGH motif; other site 751585002808 nucleotide binding site [chemical binding]; other site 751585002809 active site 751585002810 KMSKS motif; other site 751585002811 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 751585002812 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 751585002813 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 751585002814 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 751585002815 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 751585002816 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 751585002817 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 751585002818 active site 751585002819 catalytic residues [active] 751585002820 metal binding site [ion binding]; metal-binding site 751585002821 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 751585002822 beta-galactosidase; Region: BGL; TIGR03356 751585002823 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 751585002824 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 751585002825 nucleotide binding site [chemical binding]; other site 751585002826 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 751585002827 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 751585002828 G1 box; other site 751585002829 putative GEF interaction site [polypeptide binding]; other site 751585002830 GTP/Mg2+ binding site [chemical binding]; other site 751585002831 Switch I region; other site 751585002832 G2 box; other site 751585002833 G3 box; other site 751585002834 Switch II region; other site 751585002835 G4 box; other site 751585002836 G5 box; other site 751585002837 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 751585002838 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 751585002839 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 751585002840 YacP-like NYN domain; Region: NYN_YacP; pfam05991 751585002841 Fic family protein [Function unknown]; Region: COG3177 751585002842 Fic/DOC family; Region: Fic; pfam02661 751585002843 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 751585002844 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 751585002845 dimer interface [polypeptide binding]; other site 751585002846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585002847 catalytic residue [active] 751585002848 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 751585002849 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 751585002850 homodimer interface [polypeptide binding]; other site 751585002851 substrate-cofactor binding pocket; other site 751585002852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585002853 catalytic residue [active] 751585002854 Transcriptional regulator; Region: Rrf2; cl17282 751585002855 Rrf2 family protein; Region: rrf2_super; TIGR00738 751585002856 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 751585002857 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 751585002858 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 751585002859 active site 751585002860 dimer interface [polypeptide binding]; other site 751585002861 motif 1; other site 751585002862 motif 2; other site 751585002863 motif 3; other site 751585002864 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 751585002865 anticodon binding site; other site 751585002866 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 751585002867 putative dimer interface [polypeptide binding]; other site 751585002868 catalytic triad [active] 751585002869 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 751585002870 AzlC protein; Region: AzlC; pfam03591 751585002871 Protein of unknown function DUF58; Region: DUF58; pfam01882 751585002872 MoxR-like ATPases [General function prediction only]; Region: COG0714 751585002873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585002874 ATP binding site [chemical binding]; other site 751585002875 Walker A motif; other site 751585002876 Walker B motif; other site 751585002877 Tetratricopeptide repeat; Region: TPR_12; pfam13424 751585002878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 751585002879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 751585002880 binding surface 751585002881 TPR motif; other site 751585002882 Tetratricopeptide repeat; Region: TPR_12; pfam13424 751585002883 Tetratricopeptide repeat; Region: TPR_12; pfam13424 751585002884 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 751585002885 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 751585002886 putative ligand binding site [chemical binding]; other site 751585002887 putative NAD binding site [chemical binding]; other site 751585002888 catalytic site [active] 751585002889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585002890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 751585002891 dimerization interface [polypeptide binding]; other site 751585002892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585002893 dimer interface [polypeptide binding]; other site 751585002894 phosphorylation site [posttranslational modification] 751585002895 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 751585002896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585002897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585002898 active site 751585002899 phosphorylation site [posttranslational modification] 751585002900 intermolecular recognition site; other site 751585002901 dimerization interface [polypeptide binding]; other site 751585002902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585002903 DNA binding site [nucleotide binding] 751585002904 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 751585002905 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 751585002906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585002907 Walker A/P-loop; other site 751585002908 ATP binding site [chemical binding]; other site 751585002909 AAA domain; Region: AAA_21; pfam13304 751585002910 Cupin domain; Region: Cupin_2; pfam07883 751585002911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 751585002912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585002913 FeoA domain; Region: FeoA; pfam04023 751585002914 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 751585002915 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 751585002916 G1 box; other site 751585002917 GTP/Mg2+ binding site [chemical binding]; other site 751585002918 Switch I region; other site 751585002919 G2 box; other site 751585002920 G3 box; other site 751585002921 Switch II region; other site 751585002922 G4 box; other site 751585002923 G5 box; other site 751585002924 Nucleoside recognition; Region: Gate; pfam07670 751585002925 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 751585002926 Nucleoside recognition; Region: Gate; pfam07670 751585002927 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585002928 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 751585002929 Protein of unknown function (DUF419); Region: DUF419; pfam04237 751585002930 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 751585002931 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 751585002932 active site 751585002933 DNA binding site [nucleotide binding] 751585002934 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 751585002935 A new structural DNA glycosylase; Region: AlkD_like; cd06561 751585002936 active site 751585002937 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 751585002938 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 751585002939 substrate binding pocket [chemical binding]; other site 751585002940 membrane-bound complex binding site; other site 751585002941 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 751585002942 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 751585002943 putative NADH binding site [chemical binding]; other site 751585002944 putative active site [active] 751585002945 nudix motif; other site 751585002946 putative metal binding site [ion binding]; other site 751585002947 Carbon starvation protein CstA; Region: CstA; pfam02554 751585002948 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 751585002949 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 751585002950 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 751585002951 EamA-like transporter family; Region: EamA; pfam00892 751585002952 EamA-like transporter family; Region: EamA; pfam00892 751585002953 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585002954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585002955 metal binding site [ion binding]; metal-binding site 751585002956 active site 751585002957 I-site; other site 751585002958 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 751585002959 EDD domain protein, DegV family; Region: DegV; TIGR00762 751585002960 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 751585002961 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 751585002962 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585002963 active site 751585002964 nucleotide binding site [chemical binding]; other site 751585002965 HIGH motif; other site 751585002966 KMSKS motif; other site 751585002967 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 751585002968 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 751585002969 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 751585002970 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 751585002971 nudix motif; other site 751585002972 Isochorismatase family; Region: Isochorismatase; pfam00857 751585002973 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 751585002974 catalytic triad [active] 751585002975 conserved cis-peptide bond; other site 751585002976 putative arabinose transporter; Provisional; Region: PRK03545 751585002977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 751585002978 putative substrate translocation pore; other site 751585002979 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 751585002980 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 751585002981 putative substrate binding site [chemical binding]; other site 751585002982 putative ATP binding site [chemical binding]; other site 751585002983 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 751585002984 active site 751585002985 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 751585002986 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 751585002987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 751585002988 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 751585002989 TM-ABC transporter signature motif; other site 751585002990 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 751585002991 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 751585002992 Walker A/P-loop; other site 751585002993 ATP binding site [chemical binding]; other site 751585002994 Q-loop/lid; other site 751585002995 ABC transporter signature motif; other site 751585002996 Walker B; other site 751585002997 D-loop; other site 751585002998 H-loop/switch region; other site 751585002999 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 751585003000 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 751585003001 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 751585003002 ligand binding site [chemical binding]; other site 751585003003 Transcriptional regulators [Transcription]; Region: PurR; COG1609 751585003004 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 751585003005 DNA binding site [nucleotide binding] 751585003006 domain linker motif; other site 751585003007 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 751585003008 dimerization interface [polypeptide binding]; other site 751585003009 ligand binding site [chemical binding]; other site 751585003010 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 751585003011 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 751585003012 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 751585003013 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 751585003014 active site 751585003015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585003016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 751585003017 dimer interface [polypeptide binding]; other site 751585003018 phosphorylation site [posttranslational modification] 751585003019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585003020 ATP binding site [chemical binding]; other site 751585003021 Mg2+ binding site [ion binding]; other site 751585003022 G-X-G motif; other site 751585003023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585003024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585003025 active site 751585003026 phosphorylation site [posttranslational modification] 751585003027 intermolecular recognition site; other site 751585003028 dimerization interface [polypeptide binding]; other site 751585003029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585003030 DNA binding site [nucleotide binding] 751585003031 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 751585003032 FtsX-like permease family; Region: FtsX; pfam02687 751585003033 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585003034 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585003035 Walker A/P-loop; other site 751585003036 ATP binding site [chemical binding]; other site 751585003037 Q-loop/lid; other site 751585003038 ABC transporter signature motif; other site 751585003039 Walker B; other site 751585003040 D-loop; other site 751585003041 H-loop/switch region; other site 751585003042 xanthine permease; Region: pbuX; TIGR03173 751585003043 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 751585003044 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 751585003045 active site 751585003046 catalytic site [active] 751585003047 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 751585003048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585003049 Walker A motif; other site 751585003050 ATP binding site [chemical binding]; other site 751585003051 Walker B motif; other site 751585003052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 751585003053 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 751585003054 DNA binding residues [nucleotide binding] 751585003055 dimerization interface [polypeptide binding]; other site 751585003056 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585003057 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585003058 Walker A/P-loop; other site 751585003059 ATP binding site [chemical binding]; other site 751585003060 Q-loop/lid; other site 751585003061 ABC transporter signature motif; other site 751585003062 Walker B; other site 751585003063 D-loop; other site 751585003064 H-loop/switch region; other site 751585003065 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 751585003066 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 751585003067 RelB antitoxin; Region: RelB; cl01171 751585003068 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 751585003069 RelB antitoxin; Region: RelB; cl01171 751585003070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 751585003071 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 751585003072 Coenzyme A transferase; Region: CoA_trans; smart00882 751585003073 Coenzyme A transferase; Region: CoA_trans; cl17247 751585003074 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 751585003075 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 751585003076 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 751585003077 Membrane transport protein; Region: Mem_trans; cl09117 751585003078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 751585003079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 751585003080 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 751585003081 catalytic triad [active] 751585003082 active site nucleophile [active] 751585003083 Predicted transcriptional regulators [Transcription]; Region: COG1733 751585003084 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 751585003085 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 751585003086 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 751585003087 Int/Topo IB signature motif; other site 751585003088 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585003089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003090 non-specific DNA binding site [nucleotide binding]; other site 751585003091 salt bridge; other site 751585003092 sequence-specific DNA binding site [nucleotide binding]; other site 751585003093 Helix-turn-helix domain; Region: HTH_17; cl17695 751585003094 Predicted integral membrane protein [Function unknown]; Region: COG5658 751585003095 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 751585003096 SdpI/YhfL protein family; Region: SdpI; pfam13630 751585003097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 751585003098 dimerization interface [polypeptide binding]; other site 751585003099 putative DNA binding site [nucleotide binding]; other site 751585003100 putative Zn2+ binding site [ion binding]; other site 751585003101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585003102 Radical SAM superfamily; Region: Radical_SAM; pfam04055 751585003103 FeS/SAM binding site; other site 751585003104 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 751585003105 MarR family; Region: MarR_2; cl17246 751585003106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 751585003107 CAAX protease self-immunity; Region: Abi; pfam02517 751585003108 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 751585003109 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 751585003110 trimer interface [polypeptide binding]; other site 751585003111 putative Zn binding site [ion binding]; other site 751585003112 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 751585003113 putative active site [active] 751585003114 nucleotide binding site [chemical binding]; other site 751585003115 nudix motif; other site 751585003116 putative metal binding site [ion binding]; other site 751585003117 myosin-cross-reactive antigen; Provisional; Region: PRK13977 751585003118 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585003119 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585003120 metal binding site [ion binding]; metal-binding site 751585003121 active site 751585003122 I-site; other site 751585003123 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 751585003124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 751585003125 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 751585003126 classical (c) SDRs; Region: SDR_c; cd05233 751585003127 NAD(P) binding site [chemical binding]; other site 751585003128 active site 751585003129 MarR family; Region: MarR_2; pfam12802 751585003130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 751585003131 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 751585003132 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585003133 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 751585003134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585003135 motif II; other site 751585003136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 751585003137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 751585003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585003139 dimer interface [polypeptide binding]; other site 751585003140 conserved gate region; other site 751585003141 putative PBP binding loops; other site 751585003142 ABC-ATPase subunit interface; other site 751585003143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 751585003144 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 751585003145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585003146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 751585003147 dimerization interface [polypeptide binding]; other site 751585003148 Histidine kinase; Region: His_kinase; pfam06580 751585003149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585003150 ATP binding site [chemical binding]; other site 751585003151 Mg2+ binding site [ion binding]; other site 751585003152 G-X-G motif; other site 751585003153 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 751585003154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585003155 active site 751585003156 phosphorylation site [posttranslational modification] 751585003157 intermolecular recognition site; other site 751585003158 dimerization interface [polypeptide binding]; other site 751585003159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585003160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585003161 4-alpha-glucanotransferase; Provisional; Region: PRK14508 751585003162 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 751585003163 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 751585003164 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 751585003165 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 751585003166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585003167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585003168 Peptidase family C69; Region: Peptidase_C69; pfam03577 751585003169 VanZ like family; Region: VanZ; cl01971 751585003170 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 751585003171 putative catalytic site [active] 751585003172 putative metal binding site [ion binding]; other site 751585003173 putative phosphate binding site [ion binding]; other site 751585003174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003175 salt bridge; other site 751585003176 non-specific DNA binding site [nucleotide binding]; other site 751585003177 sequence-specific DNA binding site [nucleotide binding]; other site 751585003178 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 751585003179 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 751585003180 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 751585003181 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 751585003182 Abi-like protein; Region: Abi_2; cl01988 751585003183 Abi-like protein; Region: Abi_2; pfam07751 751585003184 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 751585003185 active site 751585003186 metal binding site [ion binding]; metal-binding site 751585003187 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 751585003188 active site 751585003189 NTP binding site [chemical binding]; other site 751585003190 metal binding triad [ion binding]; metal-binding site 751585003191 antibiotic binding site [chemical binding]; other site 751585003192 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 751585003193 active site 751585003194 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 751585003195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003196 non-specific DNA binding site [nucleotide binding]; other site 751585003197 salt bridge; other site 751585003198 sequence-specific DNA binding site [nucleotide binding]; other site 751585003199 pyruvate phosphate dikinase; Provisional; Region: PRK09279 751585003200 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 751585003201 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 751585003202 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 751585003203 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 751585003204 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 751585003205 inhibitor-cofactor binding pocket; inhibition site 751585003206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585003207 catalytic residue [active] 751585003208 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 751585003209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 751585003210 DNA-binding site [nucleotide binding]; DNA binding site 751585003211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585003212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585003213 homodimer interface [polypeptide binding]; other site 751585003214 catalytic residue [active] 751585003215 GTPase Era; Reviewed; Region: era; PRK00089 751585003216 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 751585003217 G1 box; other site 751585003218 GTP/Mg2+ binding site [chemical binding]; other site 751585003219 Switch I region; other site 751585003220 G2 box; other site 751585003221 Switch II region; other site 751585003222 G3 box; other site 751585003223 G4 box; other site 751585003224 G5 box; other site 751585003225 KH domain; Region: KH_2; pfam07650 751585003226 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 751585003227 active site 751585003228 catalytic motif [active] 751585003229 Zn binding site [ion binding]; other site 751585003230 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 751585003231 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 751585003232 ring oligomerisation interface [polypeptide binding]; other site 751585003233 ATP/Mg binding site [chemical binding]; other site 751585003234 stacking interactions; other site 751585003235 hinge regions; other site 751585003236 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 751585003237 oligomerisation interface [polypeptide binding]; other site 751585003238 mobile loop; other site 751585003239 roof hairpin; other site 751585003240 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 751585003241 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 751585003242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 751585003243 minor groove reading motif; other site 751585003244 helix-hairpin-helix signature motif; other site 751585003245 substrate binding pocket [chemical binding]; other site 751585003246 active site 751585003247 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 751585003248 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585003249 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 751585003250 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585003251 active site 751585003252 HIGH motif; other site 751585003253 nucleotide binding site [chemical binding]; other site 751585003254 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585003255 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 751585003256 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 751585003257 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 751585003258 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 751585003259 active site 751585003260 metal binding site [ion binding]; metal-binding site 751585003261 dimerization interface [polypeptide binding]; other site 751585003262 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 751585003263 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 751585003264 active site 751585003265 HIGH motif; other site 751585003266 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 751585003267 KMSKS motif; other site 751585003268 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 751585003269 tRNA binding surface [nucleotide binding]; other site 751585003270 anticodon binding site; other site 751585003271 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 751585003272 Family description; Region: UvrD_C_2; pfam13538 751585003273 hypothetical protein; Provisional; Region: PRK05590 751585003274 SEC-C motif; Region: SEC-C; pfam02810 751585003275 Response regulator receiver domain; Region: Response_reg; pfam00072 751585003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585003277 active site 751585003278 phosphorylation site [posttranslational modification] 751585003279 intermolecular recognition site; other site 751585003280 dimerization interface [polypeptide binding]; other site 751585003281 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 751585003282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585003283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585003284 homodimer interface [polypeptide binding]; other site 751585003285 catalytic residue [active] 751585003286 peptide chain release factor 1; Validated; Region: prfA; PRK00591 751585003287 This domain is found in peptide chain release factors; Region: PCRF; smart00937 751585003288 RF-1 domain; Region: RF-1; pfam00472 751585003289 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 751585003290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585003291 S-adenosylmethionine binding site [chemical binding]; other site 751585003292 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 751585003293 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 751585003294 G1 box; other site 751585003295 GTP/Mg2+ binding site [chemical binding]; other site 751585003296 Switch I region; other site 751585003297 G2 box; other site 751585003298 G3 box; other site 751585003299 Switch II region; other site 751585003300 G4 box; other site 751585003301 G5 box; other site 751585003302 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 751585003303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585003304 Walker A motif; other site 751585003305 ATP binding site [chemical binding]; other site 751585003306 Walker B motif; other site 751585003307 arginine finger; other site 751585003308 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 751585003309 Clp protease; Region: CLP_protease; pfam00574 751585003310 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 751585003311 oligomer interface [polypeptide binding]; other site 751585003312 active site residues [active] 751585003313 trigger factor; Provisional; Region: tig; PRK01490 751585003314 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 751585003315 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 751585003316 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 751585003317 butyrate kinase; Provisional; Region: PRK03011 751585003318 S-ribosylhomocysteinase; Provisional; Region: PRK02260 751585003319 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 751585003320 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 751585003321 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 751585003322 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 751585003323 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 751585003324 active site 751585003325 catalytic site [active] 751585003326 metal binding site [ion binding]; metal-binding site 751585003327 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 751585003328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 751585003329 nucleotide binding site [chemical binding]; other site 751585003330 xanthine permease; Region: pbuX; TIGR03173 751585003331 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 751585003332 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 751585003333 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 751585003334 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 751585003335 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 751585003336 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 751585003337 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 751585003338 intersubunit interface [polypeptide binding]; other site 751585003339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 751585003340 dimer interface [polypeptide binding]; other site 751585003341 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 751585003342 putative PBP binding regions; other site 751585003343 ABC-ATPase subunit interface; other site 751585003344 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 751585003345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585003346 Walker A/P-loop; other site 751585003347 ATP binding site [chemical binding]; other site 751585003348 Q-loop/lid; other site 751585003349 ABC transporter signature motif; other site 751585003350 Walker B; other site 751585003351 D-loop; other site 751585003352 H-loop/switch region; other site 751585003353 NTPase; Region: NTPase_1; cl17478 751585003354 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 751585003355 Ligand binding site; other site 751585003356 metal-binding site 751585003357 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 751585003358 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 751585003359 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 751585003360 LytTr DNA-binding domain; Region: LytTR; smart00850 751585003361 Condensation domain; Region: Condensation; pfam00668 751585003362 Condensation domain; Region: Condensation; pfam00668 751585003363 Phosphopantetheine attachment site; Region: PP-binding; cl09936 751585003364 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 751585003365 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 751585003366 acyl-activating enzyme (AAE) consensus motif; other site 751585003367 putative AMP binding site [chemical binding]; other site 751585003368 putative active site [active] 751585003369 putative CoA binding site [chemical binding]; other site 751585003370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 751585003371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 751585003372 TIGR02646 family protein; Region: TIGR02646 751585003373 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 751585003374 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 751585003375 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 751585003376 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 751585003377 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585003378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003379 non-specific DNA binding site [nucleotide binding]; other site 751585003380 salt bridge; other site 751585003381 sequence-specific DNA binding site [nucleotide binding]; other site 751585003382 elongation factor Tu; Reviewed; Region: PRK00049 751585003383 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 751585003384 G1 box; other site 751585003385 GEF interaction site [polypeptide binding]; other site 751585003386 GTP/Mg2+ binding site [chemical binding]; other site 751585003387 Switch I region; other site 751585003388 G2 box; other site 751585003389 G3 box; other site 751585003390 Switch II region; other site 751585003391 G4 box; other site 751585003392 G5 box; other site 751585003393 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 751585003394 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 751585003395 Antibiotic Binding Site [chemical binding]; other site 751585003396 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 751585003397 S17 interaction site [polypeptide binding]; other site 751585003398 S8 interaction site; other site 751585003399 16S rRNA interaction site [nucleotide binding]; other site 751585003400 streptomycin interaction site [chemical binding]; other site 751585003401 23S rRNA interaction site [nucleotide binding]; other site 751585003402 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 751585003403 TetR family transcriptional regulator; Provisional; Region: PRK14996 751585003404 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 751585003405 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 751585003406 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 751585003407 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 751585003408 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 751585003409 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 751585003410 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 751585003411 G-loop; other site 751585003412 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 751585003413 DNA binding site [nucleotide binding] 751585003414 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 751585003415 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 751585003416 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 751585003417 RPB1 interaction site [polypeptide binding]; other site 751585003418 RPB10 interaction site [polypeptide binding]; other site 751585003419 RPB11 interaction site [polypeptide binding]; other site 751585003420 RPB3 interaction site [polypeptide binding]; other site 751585003421 RPB12 interaction site [polypeptide binding]; other site 751585003422 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 751585003423 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 751585003424 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 751585003425 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 751585003426 core dimer interface [polypeptide binding]; other site 751585003427 peripheral dimer interface [polypeptide binding]; other site 751585003428 L10 interface [polypeptide binding]; other site 751585003429 L11 interface [polypeptide binding]; other site 751585003430 putative EF-Tu interaction site [polypeptide binding]; other site 751585003431 putative EF-G interaction site [polypeptide binding]; other site 751585003432 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 751585003433 23S rRNA interface [nucleotide binding]; other site 751585003434 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 751585003435 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 751585003436 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 751585003437 active site 751585003438 metal binding site [ion binding]; metal-binding site 751585003439 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 751585003440 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 751585003441 active site 751585003442 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 751585003443 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 751585003444 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 751585003445 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 751585003446 tetramerization interface [polypeptide binding]; other site 751585003447 active site 751585003448 hypothetical protein; Provisional; Region: PRK13690 751585003449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 751585003450 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 751585003451 active site 751585003452 dimer interfaces [polypeptide binding]; other site 751585003453 catalytic residues [active] 751585003454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 751585003455 Domain of unknown function (DUF1846); Region: DUF1846; pfam08903 751585003456 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 751585003457 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 751585003458 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 751585003459 LrgB-like family; Region: LrgB; pfam04172 751585003460 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 751585003461 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 751585003462 Phosphate transporter family; Region: PHO4; pfam01384 751585003463 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 751585003464 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 751585003465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 751585003466 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 751585003467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585003468 motif II; other site 751585003469 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 751585003470 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 751585003471 Nitrogen regulatory protein P-II; Region: P-II; smart00938 751585003472 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 751585003473 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 751585003474 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 751585003475 Predicted membrane protein [Function unknown]; Region: COG2510 751585003476 Predicted membrane protein [Function unknown]; Region: COG2510 751585003477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585003478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585003479 active site 751585003480 phosphorylation site [posttranslational modification] 751585003481 intermolecular recognition site; other site 751585003482 dimerization interface [polypeptide binding]; other site 751585003483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585003484 DNA binding site [nucleotide binding] 751585003485 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 751585003486 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 751585003487 Ligand Binding Site [chemical binding]; other site 751585003488 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 751585003489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585003490 dimer interface [polypeptide binding]; other site 751585003491 phosphorylation site [posttranslational modification] 751585003492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585003493 ATP binding site [chemical binding]; other site 751585003494 Mg2+ binding site [ion binding]; other site 751585003495 G-X-G motif; other site 751585003496 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 751585003497 TrkA-N domain; Region: TrkA_N; pfam02254 751585003498 TrkA-C domain; Region: TrkA_C; pfam02080 751585003499 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 751585003500 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 751585003501 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 751585003502 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 751585003503 TPP-binding site; other site 751585003504 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 751585003505 PYR/PP interface [polypeptide binding]; other site 751585003506 dimer interface [polypeptide binding]; other site 751585003507 TPP binding site [chemical binding]; other site 751585003508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 751585003509 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 751585003510 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 751585003511 DNA binding residues [nucleotide binding] 751585003512 putative dimer interface [polypeptide binding]; other site 751585003513 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585003514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003515 non-specific DNA binding site [nucleotide binding]; other site 751585003516 salt bridge; other site 751585003517 sequence-specific DNA binding site [nucleotide binding]; other site 751585003518 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 751585003519 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 751585003520 active site 751585003521 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 751585003522 serpin-like protein; Provisional; Region: PHA02660 751585003523 reactive center loop; other site 751585003524 Cache domain; Region: Cache_1; pfam02743 751585003525 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 751585003526 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585003527 Zn2+ binding site [ion binding]; other site 751585003528 Mg2+ binding site [ion binding]; other site 751585003529 Response regulator receiver domain; Region: Response_reg; pfam00072 751585003530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585003531 active site 751585003532 phosphorylation site [posttranslational modification] 751585003533 intermolecular recognition site; other site 751585003534 dimerization interface [polypeptide binding]; other site 751585003535 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585003536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003537 non-specific DNA binding site [nucleotide binding]; other site 751585003538 salt bridge; other site 751585003539 sequence-specific DNA binding site [nucleotide binding]; other site 751585003540 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585003541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003542 non-specific DNA binding site [nucleotide binding]; other site 751585003543 salt bridge; other site 751585003544 sequence-specific DNA binding site [nucleotide binding]; other site 751585003545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 751585003546 active site 751585003547 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 751585003548 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 751585003549 catalytic residues [active] 751585003550 catalytic nucleophile [active] 751585003551 Recombinase; Region: Recombinase; pfam07508 751585003552 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 751585003553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 751585003554 non-specific DNA binding site [nucleotide binding]; other site 751585003555 salt bridge; other site 751585003556 sequence-specific DNA binding site [nucleotide binding]; other site 751585003557 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 751585003558 CHC2 zinc finger; Region: zf-CHC2; cl17510 751585003559 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585003560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003561 non-specific DNA binding site [nucleotide binding]; other site 751585003562 salt bridge; other site 751585003563 sequence-specific DNA binding site [nucleotide binding]; other site 751585003564 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 751585003565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 751585003566 Predicted transcriptional regulators [Transcription]; Region: COG1695 751585003567 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 751585003568 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 751585003569 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 751585003570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585003571 S-adenosylmethionine binding site [chemical binding]; other site 751585003572 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 751585003573 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 751585003574 active site 751585003575 metal binding site [ion binding]; metal-binding site 751585003576 homotetramer interface [polypeptide binding]; other site 751585003577 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 751585003578 active site 751585003579 dimerization interface [polypeptide binding]; other site 751585003580 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 751585003581 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 751585003582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 751585003583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 751585003584 active site residue [active] 751585003585 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 751585003586 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 751585003587 active site 751585003588 HIGH motif; other site 751585003589 nucleotide binding site [chemical binding]; other site 751585003590 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 751585003591 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 751585003592 active site 751585003593 KMSKS motif; other site 751585003594 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 751585003595 tRNA binding surface [nucleotide binding]; other site 751585003596 anticodon binding site; other site 751585003597 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 751585003598 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 751585003599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585003600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585003601 homodimer interface [polypeptide binding]; other site 751585003602 catalytic residue [active] 751585003603 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 751585003604 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 751585003605 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 751585003606 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 751585003607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585003608 dimer interface [polypeptide binding]; other site 751585003609 conserved gate region; other site 751585003610 ABC-ATPase subunit interface; other site 751585003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585003612 dimer interface [polypeptide binding]; other site 751585003613 conserved gate region; other site 751585003614 putative PBP binding loops; other site 751585003615 ABC-ATPase subunit interface; other site 751585003616 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 751585003617 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 751585003618 Walker A/P-loop; other site 751585003619 ATP binding site [chemical binding]; other site 751585003620 Q-loop/lid; other site 751585003621 ABC transporter signature motif; other site 751585003622 Walker B; other site 751585003623 D-loop; other site 751585003624 H-loop/switch region; other site 751585003625 TOBE domain; Region: TOBE_2; pfam08402 751585003626 TOBE domain; Region: TOBE_2; pfam08402 751585003627 TraX protein; Region: TraX; pfam05857 751585003628 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 751585003629 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 751585003630 substrate binding [chemical binding]; other site 751585003631 active site 751585003632 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 751585003633 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 751585003634 V-type ATP synthase subunit B; Provisional; Region: PRK04196 751585003635 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 751585003636 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 751585003637 Walker A motif homologous position; other site 751585003638 Walker B motif; other site 751585003639 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 751585003640 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 751585003641 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 751585003642 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 751585003643 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 751585003644 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 751585003645 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 751585003646 V-type ATP synthase subunit I; Validated; Region: PRK05771 751585003647 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 751585003648 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 751585003649 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 751585003650 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 751585003651 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 751585003652 active site 751585003653 metal binding site [ion binding]; metal-binding site 751585003654 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 751585003655 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 751585003656 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 751585003657 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 751585003658 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 751585003659 6-phosphofructokinase; Provisional; Region: PRK03202 751585003660 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 751585003661 active site 751585003662 ADP/pyrophosphate binding site [chemical binding]; other site 751585003663 dimerization interface [polypeptide binding]; other site 751585003664 allosteric effector site; other site 751585003665 fructose-1,6-bisphosphate binding site; other site 751585003666 recombination protein RecR; Reviewed; Region: recR; PRK00076 751585003667 RecR protein; Region: RecR; pfam02132 751585003668 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 751585003669 putative active site [active] 751585003670 putative metal-binding site [ion binding]; other site 751585003671 tetramer interface [polypeptide binding]; other site 751585003672 hypothetical protein; Validated; Region: PRK00153 751585003673 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 751585003674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585003675 Walker A motif; other site 751585003676 ATP binding site [chemical binding]; other site 751585003677 Walker B motif; other site 751585003678 arginine finger; other site 751585003679 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 751585003680 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 751585003681 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 751585003682 phosphopeptide binding site; other site 751585003683 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 751585003684 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 751585003685 ATP binding site [chemical binding]; other site 751585003686 Walker A motif; other site 751585003687 hexamer interface [polypeptide binding]; other site 751585003688 Walker B motif; other site 751585003689 AAA domain; Region: AAA_31; pfam13614 751585003690 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 751585003691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585003692 dimer interface [polypeptide binding]; other site 751585003693 phosphorylation site [posttranslational modification] 751585003694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585003695 ATP binding site [chemical binding]; other site 751585003696 Mg2+ binding site [ion binding]; other site 751585003697 G-X-G motif; other site 751585003698 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 751585003699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585003700 active site 751585003701 phosphorylation site [posttranslational modification] 751585003702 intermolecular recognition site; other site 751585003703 dimerization interface [polypeptide binding]; other site 751585003704 Predicted membrane protein [Function unknown]; Region: COG2246 751585003705 GtrA-like protein; Region: GtrA; pfam04138 751585003706 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 751585003707 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 751585003708 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 751585003709 endoglucanase; Region: PLN02308 751585003710 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 751585003711 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 751585003712 active site 751585003713 stage V sporulation protein K; Region: spore_V_K; TIGR02881 751585003714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 751585003715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585003716 Walker A motif; other site 751585003717 ATP binding site [chemical binding]; other site 751585003718 Walker B motif; other site 751585003719 arginine finger; other site 751585003720 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 751585003721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 751585003722 active site 751585003723 rod shape-determining protein Mbl; Provisional; Region: PRK13928 751585003724 MreB and similar proteins; Region: MreB_like; cd10225 751585003725 nucleotide binding site [chemical binding]; other site 751585003726 Mg binding site [ion binding]; other site 751585003727 putative protofilament interaction site [polypeptide binding]; other site 751585003728 RodZ interaction site [polypeptide binding]; other site 751585003729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 751585003730 PAS fold; Region: PAS_3; pfam08447 751585003731 putative active site [active] 751585003732 heme pocket [chemical binding]; other site 751585003733 Sensory domain found in PocR; Region: PocR; pfam10114 751585003734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 751585003735 GAF domain; Region: GAF; pfam01590 751585003736 hypothetical protein; Provisional; Region: PRK00106 751585003737 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 751585003738 phosphopeptide binding site; other site 751585003739 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 751585003740 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 751585003741 glutaminase active site [active] 751585003742 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 751585003743 dimer interface [polypeptide binding]; other site 751585003744 active site 751585003745 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 751585003746 dimer interface [polypeptide binding]; other site 751585003747 active site 751585003748 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 751585003749 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 751585003750 active site 751585003751 HIGH motif; other site 751585003752 KMSKS motif; other site 751585003753 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 751585003754 tRNA binding surface [nucleotide binding]; other site 751585003755 anticodon binding site; other site 751585003756 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 751585003757 dimer interface [polypeptide binding]; other site 751585003758 putative tRNA-binding site [nucleotide binding]; other site 751585003759 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 751585003760 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 751585003761 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 751585003762 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 751585003763 ornithine carbamoyltransferase; Provisional; Region: PRK14804 751585003764 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 751585003765 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 751585003766 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 751585003767 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 751585003768 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 751585003769 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 751585003770 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 751585003771 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 751585003772 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 751585003773 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 751585003774 hinge; other site 751585003775 active site 751585003776 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 751585003777 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 751585003778 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 751585003779 S-adenosylmethionine synthetase; Validated; Region: PRK05250 751585003780 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 751585003781 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 751585003782 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 751585003783 TraX protein; Region: TraX; pfam05857 751585003784 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 751585003785 HIT family signature motif; other site 751585003786 catalytic residue [active] 751585003787 Predicted amidohydrolase [General function prediction only]; Region: COG0388 751585003788 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 751585003789 active site 751585003790 catalytic triad [active] 751585003791 dimer interface [polypeptide binding]; other site 751585003792 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 751585003793 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585003794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585003795 non-specific DNA binding site [nucleotide binding]; other site 751585003796 salt bridge; other site 751585003797 sequence-specific DNA binding site [nucleotide binding]; other site 751585003798 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 751585003799 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 751585003800 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 751585003801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 751585003802 PrcB C-terminal; Region: PrcB_C; pfam14343 751585003803 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 751585003804 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 751585003805 dimer interface [polypeptide binding]; other site 751585003806 anticodon binding site; other site 751585003807 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 751585003808 homodimer interface [polypeptide binding]; other site 751585003809 motif 1; other site 751585003810 active site 751585003811 motif 2; other site 751585003812 GAD domain; Region: GAD; pfam02938 751585003813 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 751585003814 motif 3; other site 751585003815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585003816 Zn2+ binding site [ion binding]; other site 751585003817 Mg2+ binding site [ion binding]; other site 751585003818 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 751585003819 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 751585003820 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585003821 Zn2+ binding site [ion binding]; other site 751585003822 Mg2+ binding site [ion binding]; other site 751585003823 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 751585003824 synthetase active site [active] 751585003825 NTP binding site [chemical binding]; other site 751585003826 metal binding site [ion binding]; metal-binding site 751585003827 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 751585003828 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 751585003829 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 751585003830 active site 751585003831 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 751585003832 DHH family; Region: DHH; pfam01368 751585003833 DHHA1 domain; Region: DHHA1; pfam02272 751585003834 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 751585003835 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 751585003836 dimer interface [polypeptide binding]; other site 751585003837 active site 751585003838 metal binding site [ion binding]; metal-binding site 751585003839 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 751585003840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585003841 motif II; other site 751585003842 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 751585003843 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 751585003844 Protein export membrane protein; Region: SecD_SecF; pfam02355 751585003845 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 751585003846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585003847 FeS/SAM binding site; other site 751585003848 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 751585003849 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 751585003850 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 751585003851 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 751585003852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585003853 motif II; other site 751585003854 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 751585003855 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 751585003856 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 751585003857 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 751585003858 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 751585003859 RNA polymerase sigma factor; Provisional; Region: PRK05901 751585003860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 751585003861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 751585003862 active site 751585003863 ATP binding site [chemical binding]; other site 751585003864 substrate binding site [chemical binding]; other site 751585003865 activation loop (A-loop); other site 751585003866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 751585003867 binding surface 751585003868 TPR motif; other site 751585003869 Formate hydrogenlyase maturation protein HycH; Region: HycH; cl06472 751585003870 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 751585003871 active site 751585003872 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 751585003873 phosphopeptide binding site; other site 751585003874 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 751585003875 active site 751585003876 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 751585003877 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 751585003878 Walker A/P-loop; other site 751585003879 ATP binding site [chemical binding]; other site 751585003880 Q-loop/lid; other site 751585003881 ABC transporter signature motif; other site 751585003882 Walker B; other site 751585003883 D-loop; other site 751585003884 H-loop/switch region; other site 751585003885 Accessory gene regulator B; Region: AgrB; cl01873 751585003886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585003887 ATP binding site [chemical binding]; other site 751585003888 Mg2+ binding site [ion binding]; other site 751585003889 G-X-G motif; other site 751585003890 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 751585003891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585003892 active site 751585003893 phosphorylation site [posttranslational modification] 751585003894 intermolecular recognition site; other site 751585003895 dimerization interface [polypeptide binding]; other site 751585003896 LytTr DNA-binding domain; Region: LytTR; smart00850 751585003897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585003898 ATP binding site [chemical binding]; other site 751585003899 Mg2+ binding site [ion binding]; other site 751585003900 G-X-G motif; other site 751585003901 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 751585003902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 751585003903 active site 751585003904 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 751585003905 substrate binding site [chemical binding]; other site 751585003906 catalytic residues [active] 751585003907 dimer interface [polypeptide binding]; other site 751585003908 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 751585003909 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 751585003910 acyl-activating enzyme (AAE) consensus motif; other site 751585003911 AMP binding site [chemical binding]; other site 751585003912 active site 751585003913 CoA binding site [chemical binding]; other site 751585003914 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 751585003915 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 751585003916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 751585003917 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 751585003918 acyl-activating enzyme (AAE) consensus motif; other site 751585003919 AMP binding site [chemical binding]; other site 751585003920 active site 751585003921 CoA binding site [chemical binding]; other site 751585003922 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 751585003923 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 751585003924 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 751585003925 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 751585003926 PYR/PP interface [polypeptide binding]; other site 751585003927 TPP binding site [chemical binding]; other site 751585003928 dimer interface [polypeptide binding]; other site 751585003929 substrate binding site [chemical binding]; other site 751585003930 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 751585003931 TPP-binding site; other site 751585003932 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 751585003933 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 751585003934 alanine racemase; Reviewed; Region: alr; PRK00053 751585003935 active site 751585003936 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 751585003937 dimer interface [polypeptide binding]; other site 751585003938 substrate binding site [chemical binding]; other site 751585003939 catalytic residues [active] 751585003940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 751585003941 non-specific DNA binding site [nucleotide binding]; other site 751585003942 salt bridge; other site 751585003943 sequence-specific DNA binding site [nucleotide binding]; other site 751585003944 Predicted methyltransferases [General function prediction only]; Region: COG0313 751585003945 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 751585003946 putative SAM binding site [chemical binding]; other site 751585003947 putative homodimer interface [polypeptide binding]; other site 751585003948 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 751585003949 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 751585003950 DNA polymerase III subunit delta'; Validated; Region: PRK05917 751585003951 thymidylate kinase; Validated; Region: tmk; PRK00698 751585003952 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 751585003953 TMP-binding site; other site 751585003954 ATP-binding site [chemical binding]; other site 751585003955 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 751585003956 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 751585003957 active site 751585003958 catalytic tetrad [active] 751585003959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 751585003960 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 751585003961 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 751585003962 HflX GTPase family; Region: HflX; cd01878 751585003963 G1 box; other site 751585003964 GTP/Mg2+ binding site [chemical binding]; other site 751585003965 Switch I region; other site 751585003966 G2 box; other site 751585003967 G3 box; other site 751585003968 Switch II region; other site 751585003969 G4 box; other site 751585003970 G5 box; other site 751585003971 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 751585003972 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585003973 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 751585003974 Carbohydrate binding module 27; Region: CBM27; pfam09212 751585003975 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 751585003976 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 751585003977 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585003978 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585003979 Walker A/P-loop; other site 751585003980 ATP binding site [chemical binding]; other site 751585003981 Q-loop/lid; other site 751585003982 ABC transporter signature motif; other site 751585003983 Walker B; other site 751585003984 D-loop; other site 751585003985 H-loop/switch region; other site 751585003986 FtsX-like permease family; Region: FtsX; pfam02687 751585003987 aminotransferase AlaT; Validated; Region: PRK09265 751585003988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585003989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585003990 homodimer interface [polypeptide binding]; other site 751585003991 catalytic residue [active] 751585003992 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 751585003993 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 751585003994 substrate binding pocket [chemical binding]; other site 751585003995 Helix-turn-helix domain; Region: HTH_17; pfam12728 751585003996 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 751585003997 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 751585003998 Rubredoxin; Region: Rubredoxin; pfam00301 751585003999 iron binding site [ion binding]; other site 751585004000 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 751585004001 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 751585004002 Predicted transcriptional regulators [Transcription]; Region: COG1725 751585004003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 751585004004 DNA-binding site [nucleotide binding]; DNA binding site 751585004005 Predicted membrane protein [General function prediction only]; Region: COG4194 751585004006 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 751585004007 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 751585004008 ligand binding site [chemical binding]; other site 751585004009 calcium binding site [ion binding]; other site 751585004010 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 751585004011 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 751585004012 ligand binding site [chemical binding]; other site 751585004013 dimerization interface [polypeptide binding]; other site 751585004014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585004015 active site 751585004016 phosphorylation site [posttranslational modification] 751585004017 intermolecular recognition site; other site 751585004018 dimerization interface [polypeptide binding]; other site 751585004019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 751585004020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004022 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 751585004023 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 751585004024 Walker A/P-loop; other site 751585004025 ATP binding site [chemical binding]; other site 751585004026 Q-loop/lid; other site 751585004027 ABC transporter signature motif; other site 751585004028 Walker B; other site 751585004029 D-loop; other site 751585004030 H-loop/switch region; other site 751585004031 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 751585004032 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 751585004033 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 751585004034 TraX protein; Region: TraX; pfam05857 751585004035 Protein of unknown function (DUF975); Region: DUF975; cl10504 751585004036 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 751585004037 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 751585004038 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 751585004039 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 751585004040 Rhomboid family; Region: Rhomboid; pfam01694 751585004041 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 751585004042 metal binding site [ion binding]; metal-binding site 751585004043 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 751585004044 NAD binding site [chemical binding]; other site 751585004045 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585004046 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585004047 Walker A/P-loop; other site 751585004048 ATP binding site [chemical binding]; other site 751585004049 Q-loop/lid; other site 751585004050 ABC transporter signature motif; other site 751585004051 Walker B; other site 751585004052 D-loop; other site 751585004053 H-loop/switch region; other site 751585004054 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 751585004055 FtsX-like permease family; Region: FtsX; pfam02687 751585004056 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 751585004057 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 751585004058 intersubunit interface [polypeptide binding]; other site 751585004059 active site 751585004060 zinc binding site [ion binding]; other site 751585004061 Na+ binding site [ion binding]; other site 751585004062 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 751585004063 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 751585004064 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 751585004065 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 751585004066 excinuclease ABC subunit B; Provisional; Region: PRK05298 751585004067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 751585004068 ATP binding site [chemical binding]; other site 751585004069 putative Mg++ binding site [ion binding]; other site 751585004070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 751585004071 nucleotide binding region [chemical binding]; other site 751585004072 ATP-binding site [chemical binding]; other site 751585004073 Ultra-violet resistance protein B; Region: UvrB; pfam12344 751585004074 UvrB/uvrC motif; Region: UVR; pfam02151 751585004075 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 751585004076 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 751585004077 substrate binding site [chemical binding]; other site 751585004078 active site 751585004079 catalytic residues [active] 751585004080 heterodimer interface [polypeptide binding]; other site 751585004081 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 751585004082 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 751585004083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585004084 catalytic residue [active] 751585004085 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 751585004086 active site 751585004087 ribulose/triose binding site [chemical binding]; other site 751585004088 phosphate binding site [ion binding]; other site 751585004089 substrate (anthranilate) binding pocket [chemical binding]; other site 751585004090 product (indole) binding pocket [chemical binding]; other site 751585004091 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 751585004092 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 751585004093 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 751585004094 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 751585004095 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 751585004096 glutamine binding [chemical binding]; other site 751585004097 catalytic triad [active] 751585004098 anthranilate synthase component I; Provisional; Region: PRK13565 751585004099 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 751585004100 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 751585004101 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585004102 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 751585004103 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 751585004104 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 751585004105 active site 751585004106 catalytic tetrad [active] 751585004107 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 751585004108 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 751585004109 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 751585004110 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 751585004111 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 751585004112 metal binding site [ion binding]; metal-binding site 751585004113 dimer interface [polypeptide binding]; other site 751585004114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585004115 S-adenosylmethionine binding site [chemical binding]; other site 751585004116 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 751585004117 ATP binding site [chemical binding]; other site 751585004118 Mg2+ binding site [ion binding]; other site 751585004119 G-X-G motif; other site 751585004120 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 751585004121 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 751585004122 active site 751585004123 HIGH motif; other site 751585004124 KMSK motif region; other site 751585004125 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 751585004126 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 751585004127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585004128 S-adenosylmethionine binding site [chemical binding]; other site 751585004129 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 751585004130 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 751585004131 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 751585004132 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 751585004133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585004134 Walker A motif; other site 751585004135 ATP binding site [chemical binding]; other site 751585004136 Walker B motif; other site 751585004137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 751585004138 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 751585004139 DnaA box-binding interface [nucleotide binding]; other site 751585004140 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 751585004141 RNA binding surface [nucleotide binding]; other site 751585004142 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 751585004143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585004144 Mg2+ binding site [ion binding]; other site 751585004145 G-X-G motif; other site 751585004146 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 751585004147 anchoring element; other site 751585004148 dimer interface [polypeptide binding]; other site 751585004149 ATP binding site [chemical binding]; other site 751585004150 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 751585004151 active site 751585004152 putative metal-binding site [ion binding]; other site 751585004153 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 751585004154 DNA gyrase subunit A; Validated; Region: PRK05560 751585004155 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 751585004156 CAP-like domain; other site 751585004157 active site 751585004158 primary dimer interface [polypeptide binding]; other site 751585004159 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 751585004160 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 751585004161 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 751585004162 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 751585004163 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 751585004164 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 751585004165 Baculoviral E56 protein, specific to ODV envelope; Region: Baculo_E56; pfam04639 751585004166 fumarate hydratase; Provisional; Region: PRK06246 751585004167 Fumarase C-terminus; Region: Fumerase_C; cl00795 751585004168 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585004169 Interdomain contacts; other site 751585004170 Cytokine receptor motif; other site 751585004171 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 751585004172 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 751585004173 phosphopeptide binding site; other site 751585004174 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 751585004175 Tetratricopeptide repeat; Region: TPR_16; pfam13432 751585004176 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 751585004177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 751585004178 binding surface 751585004179 TPR motif; other site 751585004180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 751585004181 binding surface 751585004182 TPR motif; other site 751585004183 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 751585004184 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 751585004185 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 751585004186 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 751585004187 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 751585004188 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 751585004189 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 751585004190 DNA binding residues [nucleotide binding] 751585004191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585004192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 751585004193 dimerization interface [polypeptide binding]; other site 751585004194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585004195 dimer interface [polypeptide binding]; other site 751585004196 phosphorylation site [posttranslational modification] 751585004197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585004198 ATP binding site [chemical binding]; other site 751585004199 Mg2+ binding site [ion binding]; other site 751585004200 G-X-G motif; other site 751585004201 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 751585004202 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 751585004203 active site 751585004204 prolyl-tRNA synthetase; Provisional; Region: PRK08661 751585004205 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 751585004206 dimer interface [polypeptide binding]; other site 751585004207 motif 1; other site 751585004208 active site 751585004209 motif 2; other site 751585004210 motif 3; other site 751585004211 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 751585004212 anticodon binding site; other site 751585004213 zinc-binding site [ion binding]; other site 751585004214 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 751585004215 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 751585004216 active site 751585004217 NTP binding site [chemical binding]; other site 751585004218 metal binding triad [ion binding]; metal-binding site 751585004219 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 751585004220 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585004221 Zn2+ binding site [ion binding]; other site 751585004222 Mg2+ binding site [ion binding]; other site 751585004223 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 751585004224 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 751585004225 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 751585004226 active site 751585004227 substrate binding site [chemical binding]; other site 751585004228 metal binding site [ion binding]; metal-binding site 751585004229 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 751585004230 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 751585004231 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 751585004232 Ligand binding site; other site 751585004233 Putative Catalytic site; other site 751585004234 DXD motif; other site 751585004235 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 751585004236 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 751585004237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004239 Protein of unknown function, DUF624; Region: DUF624; pfam04854 751585004240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585004241 dimer interface [polypeptide binding]; other site 751585004242 conserved gate region; other site 751585004243 putative PBP binding loops; other site 751585004244 ABC-ATPase subunit interface; other site 751585004245 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 751585004246 Melibiase; Region: Melibiase; pfam02065 751585004247 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585004248 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 751585004249 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 751585004250 HIGH motif; other site 751585004251 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 751585004252 active site 751585004253 KMSKS motif; other site 751585004254 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 751585004255 tRNA binding surface [nucleotide binding]; other site 751585004256 anticodon binding site; other site 751585004257 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 751585004258 putative active site [active] 751585004259 putative metal binding site [ion binding]; other site 751585004260 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 751585004261 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 751585004262 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 751585004263 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 751585004264 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 751585004265 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 751585004266 nucleotide binding site [chemical binding]; other site 751585004267 NEF interaction site [polypeptide binding]; other site 751585004268 SBD interface [polypeptide binding]; other site 751585004269 DNA polymerase II large subunit DP2; Region: PolC_DP2; pfam03833 751585004270 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 751585004271 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 751585004272 HSP70 interaction site [polypeptide binding]; other site 751585004273 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 751585004274 homodimer interface [polypeptide binding]; other site 751585004275 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 751585004276 active site pocket [active] 751585004277 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 751585004278 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 751585004279 DNA-binding site [nucleotide binding]; DNA binding site 751585004280 RNA-binding motif; other site 751585004281 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 751585004282 Stage II sporulation protein; Region: SpoIID; pfam08486 751585004283 Peptidase family M23; Region: Peptidase_M23; pfam01551 751585004284 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 751585004285 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 751585004286 catalytic domain interface [polypeptide binding]; other site 751585004287 homodimer interface [polypeptide binding]; other site 751585004288 putative active site [active] 751585004289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585004290 Walker A/P-loop; other site 751585004291 ATP binding site [chemical binding]; other site 751585004292 ABC transporter; Region: ABC_tran; pfam00005 751585004293 Q-loop/lid; other site 751585004294 ABC transporter signature motif; other site 751585004295 Walker B; other site 751585004296 D-loop; other site 751585004297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 751585004298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 751585004299 DNA binding site [nucleotide binding] 751585004300 domain linker motif; other site 751585004301 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 751585004302 ligand binding site [chemical binding]; other site 751585004303 dimerization interface [polypeptide binding]; other site 751585004304 sulfate transport protein; Provisional; Region: cysT; CHL00187 751585004305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585004306 dimer interface [polypeptide binding]; other site 751585004307 conserved gate region; other site 751585004308 putative PBP binding loops; other site 751585004309 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 751585004310 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 751585004311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 751585004312 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 751585004313 active site 751585004314 catalytic residues [active] 751585004315 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 751585004316 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 751585004317 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 751585004318 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 751585004319 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 751585004320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 751585004321 DNA-binding site [nucleotide binding]; DNA binding site 751585004322 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 751585004323 FCD domain; Region: FCD; pfam07729 751585004324 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 751585004325 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 751585004326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585004327 S-adenosylmethionine binding site [chemical binding]; other site 751585004328 CAAX protease self-immunity; Region: Abi; pfam02517 751585004329 4-alpha-glucanotransferase; Provisional; Region: PRK14508 751585004330 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 751585004331 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 751585004332 active site 751585004333 EDD domain protein, DegV family; Region: DegV; TIGR00762 751585004334 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 751585004335 Maf-like protein; Reviewed; Region: PRK00078 751585004336 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 751585004337 active site 751585004338 dimer interface [polypeptide binding]; other site 751585004339 aspartate aminotransferase; Provisional; Region: PRK06836 751585004340 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585004341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585004342 homodimer interface [polypeptide binding]; other site 751585004343 catalytic residue [active] 751585004344 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 751585004345 active site 751585004346 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 751585004347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585004348 S-adenosylmethionine binding site [chemical binding]; other site 751585004349 putative global regulator; Reviewed; Region: PRK09559 751585004350 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 751585004351 nucleoside/Zn binding site; other site 751585004352 dimer interface [polypeptide binding]; other site 751585004353 catalytic motif [active] 751585004354 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585004355 Zn2+ binding site [ion binding]; other site 751585004356 Mg2+ binding site [ion binding]; other site 751585004357 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 751585004358 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 751585004359 active site 751585004360 homodimer interface [polypeptide binding]; other site 751585004361 TSCPD domain; Region: TSCPD; cl14834 751585004362 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 751585004363 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 751585004364 DNA binding residues [nucleotide binding] 751585004365 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 751585004366 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 751585004367 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 751585004368 active site 751585004369 dimer interface [polypeptide binding]; other site 751585004370 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 751585004371 dimer interface [polypeptide binding]; other site 751585004372 active site 751585004373 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 751585004374 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 751585004375 DHH family; Region: DHH; pfam01368 751585004376 DHHA1 domain; Region: DHHA1; pfam02272 751585004377 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 751585004378 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 751585004379 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 751585004380 replicative DNA helicase; Region: DnaB; TIGR00665 751585004381 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 751585004382 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 751585004383 Walker A motif; other site 751585004384 ATP binding site [chemical binding]; other site 751585004385 Walker B motif; other site 751585004386 DNA binding loops [nucleotide binding] 751585004387 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 751585004388 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 751585004389 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 751585004390 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 751585004391 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 751585004392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585004393 motif II; other site 751585004394 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 751585004395 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 751585004396 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 751585004397 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 751585004398 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 751585004399 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 751585004400 putative RNA binding site [nucleotide binding]; other site 751585004401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585004402 S-adenosylmethionine binding site [chemical binding]; other site 751585004403 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 751585004404 Predicted membrane protein [Function unknown]; Region: COG2246 751585004405 GtrA-like protein; Region: GtrA; pfam04138 751585004406 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 751585004407 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 751585004408 dimer interface [polypeptide binding]; other site 751585004409 active site 751585004410 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 751585004411 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 751585004412 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 751585004413 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 751585004414 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 751585004415 Protein of unknown function DUF45; Region: DUF45; pfam01863 751585004416 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 751585004417 dimer interface [polypeptide binding]; other site 751585004418 active site 751585004419 citrylCoA binding site [chemical binding]; other site 751585004420 Citrate synthase; Region: Citrate_synt; pfam00285 751585004421 oxalacetate/citrate binding site [chemical binding]; other site 751585004422 coenzyme A binding site [chemical binding]; other site 751585004423 catalytic triad [active] 751585004424 Transglutaminase/protease-like homologues; Region: TGc; smart00460 751585004425 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 751585004426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585004427 ABC transporter; Region: ABC_tran_2; pfam12848 751585004428 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585004429 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 751585004430 regulatory protein interface [polypeptide binding]; other site 751585004431 regulatory phosphorylation site [posttranslational modification]; other site 751585004432 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 751585004433 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 751585004434 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 751585004435 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 751585004436 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 751585004437 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 751585004438 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 751585004439 putative ligand binding site [chemical binding]; other site 751585004440 putative NAD binding site [chemical binding]; other site 751585004441 catalytic site [active] 751585004442 A new structural DNA glycosylase; Region: AlkD_like; cd06561 751585004443 active site 751585004444 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 751585004445 active site turn [active] 751585004446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 751585004447 glycogen branching enzyme; Provisional; Region: PRK12313 751585004448 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 751585004449 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 751585004450 active site 751585004451 catalytic site [active] 751585004452 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 751585004453 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 751585004454 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585004455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585004456 ABC transporter; Region: ABC_tran_2; pfam12848 751585004457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 751585004458 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 751585004459 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 751585004460 Malic enzyme, N-terminal domain; Region: malic; pfam00390 751585004461 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 751585004462 putative NAD(P) binding site [chemical binding]; other site 751585004463 LytTr DNA-binding domain; Region: LytTR; pfam04397 751585004464 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 751585004465 Helix-turn-helix domain; Region: HTH_19; pfam12844 751585004466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 751585004467 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 751585004468 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 751585004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585004470 dimer interface [polypeptide binding]; other site 751585004471 conserved gate region; other site 751585004472 putative PBP binding loops; other site 751585004473 ABC-ATPase subunit interface; other site 751585004474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 751585004475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585004476 dimer interface [polypeptide binding]; other site 751585004477 conserved gate region; other site 751585004478 putative PBP binding loops; other site 751585004479 ABC-ATPase subunit interface; other site 751585004480 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 751585004481 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 751585004482 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 751585004483 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 751585004484 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 751585004485 putative efflux protein, MATE family; Region: matE; TIGR00797 751585004486 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 751585004487 Response regulator receiver domain; Region: Response_reg; pfam00072 751585004488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585004489 active site 751585004490 phosphorylation site [posttranslational modification] 751585004491 intermolecular recognition site; other site 751585004492 dimerization interface [polypeptide binding]; other site 751585004493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585004494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585004495 dimer interface [polypeptide binding]; other site 751585004496 phosphorylation site [posttranslational modification] 751585004497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585004498 ATP binding site [chemical binding]; other site 751585004499 Mg2+ binding site [ion binding]; other site 751585004500 G-X-G motif; other site 751585004501 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 751585004502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585004503 ABC transporter signature motif; other site 751585004504 Walker B; other site 751585004505 D-loop; other site 751585004506 H-loop/switch region; other site 751585004507 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 751585004508 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 751585004509 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 751585004510 active site 751585004511 metal binding site [ion binding]; metal-binding site 751585004512 DNA binding site [nucleotide binding] 751585004513 AAA domain; Region: AAA_23; pfam13476 751585004514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585004515 Walker A/P-loop; other site 751585004516 ATP binding site [chemical binding]; other site 751585004517 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 751585004518 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 751585004519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 751585004520 active site 751585004521 DNA replication protein DnaC; Validated; Region: PRK06835 751585004522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585004523 Walker A motif; other site 751585004524 ATP binding site [chemical binding]; other site 751585004525 Walker B motif; other site 751585004526 arginine finger; other site 751585004527 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 751585004528 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 751585004529 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 751585004530 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 751585004531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 751585004532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 751585004533 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 751585004534 4Fe-4S binding domain; Region: Fer4; pfam00037 751585004535 4Fe-4S binding domain; Region: Fer4; pfam00037 751585004536 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 751585004537 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 751585004538 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 751585004539 acyl-activating enzyme (AAE) consensus motif; other site 751585004540 AMP binding site [chemical binding]; other site 751585004541 active site 751585004542 CoA binding site [chemical binding]; other site 751585004543 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 751585004544 active site 751585004545 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 751585004546 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 751585004547 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 751585004548 Interdomain contacts; other site 751585004549 Cytokine receptor motif; other site 751585004550 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 751585004551 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 751585004552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585004553 FeS/SAM binding site; other site 751585004554 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 751585004555 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 751585004556 Uncharacterized conserved protein [Function unknown]; Region: COG2966 751585004557 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 751585004558 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 751585004559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 751585004560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 751585004561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 751585004562 dimerization interface [polypeptide binding]; other site 751585004563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 751585004564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 751585004565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 751585004566 dimerization interface [polypeptide binding]; other site 751585004567 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 751585004568 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 751585004569 THF binding site; other site 751585004570 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 751585004571 substrate binding site [chemical binding]; other site 751585004572 THF binding site; other site 751585004573 zinc-binding site [ion binding]; other site 751585004574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585004575 Walker A motif; other site 751585004576 ATP binding site [chemical binding]; other site 751585004577 Walker B motif; other site 751585004578 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 751585004579 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 751585004580 active site 751585004581 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 751585004582 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 751585004583 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 751585004584 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 751585004585 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 751585004586 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 751585004587 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 751585004588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004589 Helix-turn-helix domain; Region: HTH_18; pfam12833 751585004590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004591 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 751585004592 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 751585004593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004595 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 751585004596 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 751585004597 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 751585004598 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 751585004599 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 751585004600 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 751585004601 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 751585004602 active site 751585004603 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 751585004604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 751585004605 active site 751585004606 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 751585004607 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 751585004608 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 751585004609 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 751585004610 active site 751585004611 4Fe-4S binding domain; Region: Fer4; pfam00037 751585004612 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 751585004613 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 751585004614 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 751585004615 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 751585004616 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 751585004617 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 751585004618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 751585004619 UDP-galactopyranose mutase; Region: GLF; pfam03275 751585004620 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 751585004621 Transcriptional regulators [Transcription]; Region: PurR; COG1609 751585004622 ligand binding site [chemical binding]; other site 751585004623 dimerization interface [polypeptide binding]; other site 751585004624 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585004625 metal binding site [ion binding]; metal-binding site 751585004626 active site 751585004627 I-site; other site 751585004628 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 751585004629 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 751585004630 DHHW protein; Region: DHHW; pfam14286 751585004631 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 751585004632 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 751585004633 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 751585004634 GAF domain; Region: GAF; cl17456 751585004635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585004636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585004637 dimer interface [polypeptide binding]; other site 751585004638 phosphorylation site [posttranslational modification] 751585004639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585004640 ATP binding site [chemical binding]; other site 751585004641 Mg2+ binding site [ion binding]; other site 751585004642 G-X-G motif; other site 751585004643 Response regulator receiver domain; Region: Response_reg; pfam00072 751585004644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585004645 active site 751585004646 phosphorylation site [posttranslational modification] 751585004647 intermolecular recognition site; other site 751585004648 dimerization interface [polypeptide binding]; other site 751585004649 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 751585004650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585004651 active site 751585004652 phosphorylation site [posttranslational modification] 751585004653 intermolecular recognition site; other site 751585004654 dimerization interface [polypeptide binding]; other site 751585004655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585004656 Zn2+ binding site [ion binding]; other site 751585004657 Mg2+ binding site [ion binding]; other site 751585004658 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 751585004659 putative binding surface; other site 751585004660 active site 751585004661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585004662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585004663 dimer interface [polypeptide binding]; other site 751585004664 phosphorylation site [posttranslational modification] 751585004665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585004666 ATP binding site [chemical binding]; other site 751585004667 Mg2+ binding site [ion binding]; other site 751585004668 G-X-G motif; other site 751585004669 Response regulator receiver domain; Region: Response_reg; pfam00072 751585004670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585004671 active site 751585004672 phosphorylation site [posttranslational modification] 751585004673 intermolecular recognition site; other site 751585004674 dimerization interface [polypeptide binding]; other site 751585004675 stage V sporulation protein T; Region: spore_V_T; TIGR02851 751585004676 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 751585004677 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 751585004678 IHF dimer interface [polypeptide binding]; other site 751585004679 IHF - DNA interface [nucleotide binding]; other site 751585004680 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 751585004681 RNA binding surface [nucleotide binding]; other site 751585004682 YabP family; Region: YabP; cl06766 751585004683 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 751585004684 Septum formation initiator; Region: DivIC; cl17659 751585004685 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 751585004686 TilS substrate C-terminal domain; Region: TilS_C; smart00977 751585004687 FtsH Extracellular; Region: FtsH_ext; pfam06480 751585004688 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 751585004689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585004690 Walker A motif; other site 751585004691 ATP binding site [chemical binding]; other site 751585004692 Walker B motif; other site 751585004693 arginine finger; other site 751585004694 Peptidase family M41; Region: Peptidase_M41; pfam01434 751585004695 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 751585004696 Putative serine esterase (DUF676); Region: DUF676; pfam05057 751585004697 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 751585004698 maltodextrin glucosidase; Provisional; Region: PRK10785 751585004699 homodimer interface [polypeptide binding]; other site 751585004700 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 751585004701 active site 751585004702 homodimer interface [polypeptide binding]; other site 751585004703 catalytic site [active] 751585004704 AAA domain; Region: AAA_33; pfam13671 751585004705 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 751585004706 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 751585004707 active site 751585004708 metal binding site [ion binding]; metal-binding site 751585004709 RNA ligase; Region: RNA_lig_T4_1; pfam09511 751585004710 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 751585004711 putative active site [active] 751585004712 putative metal binding site [ion binding]; other site 751585004713 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 751585004714 Predicted membrane protein [Function unknown]; Region: COG1511 751585004715 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 751585004716 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 751585004717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 751585004718 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 751585004719 NAD(P) binding site [chemical binding]; other site 751585004720 homotetramer interface [polypeptide binding]; other site 751585004721 homodimer interface [polypeptide binding]; other site 751585004722 active site 751585004723 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585004724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585004725 non-specific DNA binding site [nucleotide binding]; other site 751585004726 salt bridge; other site 751585004727 sequence-specific DNA binding site [nucleotide binding]; other site 751585004728 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 751585004729 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 751585004730 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 751585004731 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 751585004732 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 751585004733 dimer interface [polypeptide binding]; other site 751585004734 active site 751585004735 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 751585004736 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 751585004737 inhibitor-cofactor binding pocket; inhibition site 751585004738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585004739 catalytic residue [active] 751585004740 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 751585004741 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 751585004742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 751585004743 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 751585004744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585004745 dimer interface [polypeptide binding]; other site 751585004746 conserved gate region; other site 751585004747 putative PBP binding loops; other site 751585004748 ABC-ATPase subunit interface; other site 751585004749 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 751585004750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 751585004751 Walker A/P-loop; other site 751585004752 ATP binding site [chemical binding]; other site 751585004753 Q-loop/lid; other site 751585004754 ABC transporter signature motif; other site 751585004755 Walker B; other site 751585004756 D-loop; other site 751585004757 H-loop/switch region; other site 751585004758 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 751585004759 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 751585004760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 751585004761 Walker A/P-loop; other site 751585004762 ATP binding site [chemical binding]; other site 751585004763 Q-loop/lid; other site 751585004764 ABC transporter signature motif; other site 751585004765 Walker B; other site 751585004766 D-loop; other site 751585004767 H-loop/switch region; other site 751585004768 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 751585004769 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 751585004770 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 751585004771 Nitrogen regulatory protein P-II; Region: P-II; smart00938 751585004772 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 751585004773 Phosphotransferase enzyme family; Region: APH; pfam01636 751585004774 active site 751585004775 ATP binding site [chemical binding]; other site 751585004776 substrate binding site [chemical binding]; other site 751585004777 dimer interface [polypeptide binding]; other site 751585004778 peptidase; Reviewed; Region: PRK13004 751585004779 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 751585004780 metal binding site [ion binding]; metal-binding site 751585004781 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 751585004782 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 751585004783 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 751585004784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 751585004785 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585004786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585004787 non-specific DNA binding site [nucleotide binding]; other site 751585004788 salt bridge; other site 751585004789 sequence-specific DNA binding site [nucleotide binding]; other site 751585004790 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 751585004791 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 751585004792 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 751585004793 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 751585004794 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 751585004795 gamma subunit interface [polypeptide binding]; other site 751585004796 epsilon subunit interface [polypeptide binding]; other site 751585004797 LBP interface [polypeptide binding]; other site 751585004798 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 751585004799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585004800 FeS/SAM binding site; other site 751585004801 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 751585004802 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 751585004803 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 751585004804 G1 box; other site 751585004805 GTP/Mg2+ binding site [chemical binding]; other site 751585004806 Switch I region; other site 751585004807 G2 box; other site 751585004808 Switch II region; other site 751585004809 G3 box; other site 751585004810 G4 box; other site 751585004811 G5 box; other site 751585004812 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 751585004813 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 751585004814 active site 751585004815 nucleophile elbow; other site 751585004816 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585004817 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 751585004818 Sulfatase; Region: Sulfatase; cl17466 751585004819 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 751585004820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585004821 motif II; other site 751585004822 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 751585004823 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 751585004824 active site 751585004825 catalytic site [active] 751585004826 substrate binding site [chemical binding]; other site 751585004827 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 751585004828 Domain of unknown function DUF20; Region: UPF0118; pfam01594 751585004829 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 751585004830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585004831 Walker A motif; other site 751585004832 ATP binding site [chemical binding]; other site 751585004833 Walker B motif; other site 751585004834 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 751585004835 thiamine-monophosphate kinase; Region: thiL; TIGR01379 751585004836 dimerization interface [polypeptide binding]; other site 751585004837 putative ATP binding site [chemical binding]; other site 751585004838 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 751585004839 WYL domain; Region: WYL; pfam13280 751585004840 RNA polymerase factor sigma-70; Validated; Region: PRK06811 751585004841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 751585004842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585004843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 751585004844 dimerization interface [polypeptide binding]; other site 751585004845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585004846 dimer interface [polypeptide binding]; other site 751585004847 phosphorylation site [posttranslational modification] 751585004848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585004849 ATP binding site [chemical binding]; other site 751585004850 Mg2+ binding site [ion binding]; other site 751585004851 G-X-G motif; other site 751585004852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585004854 active site 751585004855 phosphorylation site [posttranslational modification] 751585004856 intermolecular recognition site; other site 751585004857 dimerization interface [polypeptide binding]; other site 751585004858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585004859 DNA binding site [nucleotide binding] 751585004860 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 751585004861 MutS domain III; Region: MutS_III; pfam05192 751585004862 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 751585004863 Walker A/P-loop; other site 751585004864 ATP binding site [chemical binding]; other site 751585004865 Q-loop/lid; other site 751585004866 ABC transporter signature motif; other site 751585004867 Walker B; other site 751585004868 D-loop; other site 751585004869 H-loop/switch region; other site 751585004870 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 751585004871 homodimer interface [polypeptide binding]; other site 751585004872 Smr domain; Region: Smr; pfam01713 751585004873 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 751585004874 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 751585004875 ArsC family; Region: ArsC; pfam03960 751585004876 putative ArsC-like catalytic residues; other site 751585004877 putative TRX-like catalytic residues [active] 751585004878 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 751585004879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 751585004880 Coenzyme A binding pocket [chemical binding]; other site 751585004881 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 751585004882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585004883 Walker A/P-loop; other site 751585004884 ATP binding site [chemical binding]; other site 751585004885 Q-loop/lid; other site 751585004886 ABC transporter signature motif; other site 751585004887 Walker B; other site 751585004888 D-loop; other site 751585004889 H-loop/switch region; other site 751585004890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585004891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585004892 active site 751585004893 phosphorylation site [posttranslational modification] 751585004894 intermolecular recognition site; other site 751585004895 dimerization interface [polypeptide binding]; other site 751585004896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585004897 DNA binding site [nucleotide binding] 751585004898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585004899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585004900 dimer interface [polypeptide binding]; other site 751585004901 phosphorylation site [posttranslational modification] 751585004902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585004903 ATP binding site [chemical binding]; other site 751585004904 Mg2+ binding site [ion binding]; other site 751585004905 G-X-G motif; other site 751585004906 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585004907 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585004908 Walker A/P-loop; other site 751585004909 ATP binding site [chemical binding]; other site 751585004910 Q-loop/lid; other site 751585004911 ABC transporter signature motif; other site 751585004912 Walker B; other site 751585004913 D-loop; other site 751585004914 H-loop/switch region; other site 751585004915 FtsX-like permease family; Region: FtsX; pfam02687 751585004916 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 751585004917 FtsX-like permease family; Region: FtsX; pfam02687 751585004918 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 751585004919 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 751585004920 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 751585004921 active site 751585004922 metal binding site [ion binding]; metal-binding site 751585004923 DNA binding site [nucleotide binding] 751585004924 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 751585004925 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 751585004926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585004927 Walker A/P-loop; other site 751585004928 ATP binding site [chemical binding]; other site 751585004929 Q-loop/lid; other site 751585004930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 751585004931 ABC transporter signature motif; other site 751585004932 Walker B; other site 751585004933 D-loop; other site 751585004934 H-loop/switch region; other site 751585004935 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 751585004936 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 751585004937 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 751585004938 nudix motif; other site 751585004939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 751585004940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 751585004941 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 751585004942 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 751585004943 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 751585004944 putative DNA binding helix; other site 751585004945 metal binding site 2 [ion binding]; metal-binding site 751585004946 metal binding site 1 [ion binding]; metal-binding site 751585004947 dimer interface [polypeptide binding]; other site 751585004948 structural Zn2+ binding site [ion binding]; other site 751585004949 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 751585004950 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 751585004951 intersubunit interface [polypeptide binding]; other site 751585004952 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 751585004953 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 751585004954 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 751585004955 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 751585004956 active site 751585004957 substrate binding site [chemical binding]; other site 751585004958 metal binding site [ion binding]; metal-binding site 751585004959 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 751585004960 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 751585004961 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 751585004962 active site 751585004963 substrate binding site [chemical binding]; other site 751585004964 metal binding site [ion binding]; metal-binding site 751585004965 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 751585004966 Melibiase; Region: Melibiase; pfam02065 751585004967 Transcriptional regulators [Transcription]; Region: PurR; COG1609 751585004968 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 751585004969 DNA binding site [nucleotide binding] 751585004970 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 751585004971 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 751585004972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 751585004973 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 751585004974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 751585004975 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 751585004976 dimerization interface [polypeptide binding]; other site 751585004977 putative active cleft [active] 751585004978 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 751585004979 active site 751585004980 Domain of unknown function (DUF377); Region: DUF377; pfam04041 751585004981 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 751585004982 active site 751585004983 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 751585004984 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 751585004985 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 751585004986 dimerization interface [polypeptide binding]; other site 751585004987 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 751585004988 ligand binding site [chemical binding]; other site 751585004989 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585004990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585004991 metal binding site [ion binding]; metal-binding site 751585004992 active site 751585004993 I-site; other site 751585004994 EDD domain protein, DegV family; Region: DegV; TIGR00762 751585004995 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 751585004996 Rrf2 family protein; Region: rrf2_super; TIGR00738 751585004997 Transcriptional regulator; Region: Rrf2; pfam02082 751585004998 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 751585004999 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 751585005000 Walker A/P-loop; other site 751585005001 ATP binding site [chemical binding]; other site 751585005002 Q-loop/lid; other site 751585005003 ABC transporter signature motif; other site 751585005004 Walker B; other site 751585005005 D-loop; other site 751585005006 H-loop/switch region; other site 751585005007 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 751585005008 FeS assembly protein SufB; Region: sufB; TIGR01980 751585005009 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 751585005010 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 751585005011 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 751585005012 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 751585005013 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 751585005014 catalytic residue [active] 751585005015 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 751585005016 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 751585005017 trimerization site [polypeptide binding]; other site 751585005018 active site 751585005019 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 751585005020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585005021 dimer interface [polypeptide binding]; other site 751585005022 phosphorylation site [posttranslational modification] 751585005023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585005024 ATP binding site [chemical binding]; other site 751585005025 Mg2+ binding site [ion binding]; other site 751585005026 G-X-G motif; other site 751585005027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585005028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585005029 active site 751585005030 phosphorylation site [posttranslational modification] 751585005031 intermolecular recognition site; other site 751585005032 dimerization interface [polypeptide binding]; other site 751585005033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585005034 DNA binding site [nucleotide binding] 751585005035 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 751585005036 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 751585005037 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 751585005038 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 751585005039 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 751585005040 active site 751585005041 catalytic triad [active] 751585005042 oxyanion hole [active] 751585005043 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 751585005044 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 751585005045 dimer interface [polypeptide binding]; other site 751585005046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585005047 catalytic residue [active] 751585005048 PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301 751585005049 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 751585005050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 751585005051 substrate binding pocket [chemical binding]; other site 751585005052 membrane-bound complex binding site; other site 751585005053 hinge residues; other site 751585005054 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 751585005055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585005056 dimer interface [polypeptide binding]; other site 751585005057 conserved gate region; other site 751585005058 putative PBP binding loops; other site 751585005059 ABC-ATPase subunit interface; other site 751585005060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585005061 dimer interface [polypeptide binding]; other site 751585005062 conserved gate region; other site 751585005063 putative PBP binding loops; other site 751585005064 ABC-ATPase subunit interface; other site 751585005065 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 751585005066 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 751585005067 Walker A/P-loop; other site 751585005068 ATP binding site [chemical binding]; other site 751585005069 Q-loop/lid; other site 751585005070 ABC transporter signature motif; other site 751585005071 Walker B; other site 751585005072 D-loop; other site 751585005073 H-loop/switch region; other site 751585005074 TOBE domain; Region: TOBE_2; pfam08402 751585005075 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 751585005076 L-aspartate oxidase; Provisional; Region: PRK06175 751585005077 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 751585005078 Ferredoxin [Energy production and conversion]; Region: COG1146 751585005079 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 751585005080 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 751585005081 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 751585005082 Active Sites [active] 751585005083 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 751585005084 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 751585005085 CysD dimerization site [polypeptide binding]; other site 751585005086 G1 box; other site 751585005087 putative GEF interaction site [polypeptide binding]; other site 751585005088 GTP/Mg2+ binding site [chemical binding]; other site 751585005089 Switch I region; other site 751585005090 G2 box; other site 751585005091 G3 box; other site 751585005092 Switch II region; other site 751585005093 G4 box; other site 751585005094 G5 box; other site 751585005095 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 751585005096 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 751585005097 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585005098 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 751585005099 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 751585005100 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 751585005101 homodimer interface [polypeptide binding]; other site 751585005102 substrate-cofactor binding pocket; other site 751585005103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585005104 catalytic residue [active] 751585005105 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 751585005106 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 751585005107 4Fe-4S binding domain; Region: Fer4; pfam00037 751585005108 4Fe-4S binding domain; Region: Fer4; pfam00037 751585005109 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 751585005110 CPxP motif; other site 751585005111 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 751585005112 catalytic residues [active] 751585005113 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 751585005114 thiS-thiF/thiG interaction site; other site 751585005115 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 751585005116 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 751585005117 ATP binding site [chemical binding]; other site 751585005118 substrate interface [chemical binding]; other site 751585005119 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 751585005120 MPN+ (JAMM) motif; other site 751585005121 Zinc-binding site [ion binding]; other site 751585005122 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 751585005123 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 751585005124 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 751585005125 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 751585005126 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 751585005127 domain interfaces; other site 751585005128 active site 751585005129 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 751585005130 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 751585005131 active site 751585005132 SAM binding site [chemical binding]; other site 751585005133 homodimer interface [polypeptide binding]; other site 751585005134 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 751585005135 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 751585005136 active site 751585005137 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 751585005138 dimer interface [polypeptide binding]; other site 751585005139 active site 751585005140 Schiff base residues; other site 751585005141 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 751585005142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 751585005143 inhibitor-cofactor binding pocket; inhibition site 751585005144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585005145 catalytic residue [active] 751585005146 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 751585005147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 751585005148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 751585005149 Predicted transcriptional regulator [Transcription]; Region: COG1959 751585005150 Transcriptional regulator; Region: Rrf2; pfam02082 751585005151 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 751585005152 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 751585005153 putative ATP binding site [chemical binding]; other site 751585005154 putative substrate interface [chemical binding]; other site 751585005155 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 751585005156 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 751585005157 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 751585005158 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 751585005159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585005160 homodimer interface [polypeptide binding]; other site 751585005161 catalytic residue [active] 751585005162 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 751585005163 MATE family multidrug exporter; Provisional; Region: PRK10189 751585005164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585005165 Walker A motif; other site 751585005166 ATP binding site [chemical binding]; other site 751585005167 Walker B motif; other site 751585005168 arginine finger; other site 751585005169 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 751585005170 Transcriptional regulators [Transcription]; Region: PurR; COG1609 751585005171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585005172 dimer interface [polypeptide binding]; other site 751585005173 conserved gate region; other site 751585005174 putative PBP binding loops; other site 751585005175 ABC-ATPase subunit interface; other site 751585005176 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 751585005177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585005178 dimer interface [polypeptide binding]; other site 751585005179 conserved gate region; other site 751585005180 putative PBP binding loops; other site 751585005181 ABC-ATPase subunit interface; other site 751585005182 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 751585005183 Melibiase; Region: Melibiase; pfam02065 751585005184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 751585005185 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 751585005186 dimerization interface [polypeptide binding]; other site 751585005187 ligand binding site [chemical binding]; other site 751585005188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585005189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585005190 metal binding site [ion binding]; metal-binding site 751585005191 active site 751585005192 I-site; other site 751585005193 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 751585005194 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 751585005195 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 751585005196 homodimer interface [polypeptide binding]; other site 751585005197 substrate-cofactor binding pocket; other site 751585005198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585005199 catalytic residue [active] 751585005200 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 751585005201 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 751585005202 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 751585005203 active site 751585005204 metal binding site [ion binding]; metal-binding site 751585005205 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 751585005206 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 751585005207 Chain length determinant protein; Region: Wzz; cl15801 751585005208 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 751585005209 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 751585005210 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 751585005211 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 751585005212 Bacterial sugar transferase; Region: Bac_transf; pfam02397 751585005213 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 751585005214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 751585005215 NAD(P) binding site [chemical binding]; other site 751585005216 active site 751585005217 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 751585005218 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 751585005219 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 751585005220 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 751585005221 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 751585005222 Rubrerythrin [Energy production and conversion]; Region: COG1592 751585005223 binuclear metal center [ion binding]; other site 751585005224 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 751585005225 iron binding site [ion binding]; other site 751585005226 Predicted membrane protein [Function unknown]; Region: COG2364 751585005227 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 751585005228 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 751585005229 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 751585005230 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 751585005231 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 751585005232 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 751585005233 Mg binding site [ion binding]; other site 751585005234 nucleotide binding site [chemical binding]; other site 751585005235 putative protofilament interface [polypeptide binding]; other site 751585005236 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 751585005237 PAS domain S-box; Region: sensory_box; TIGR00229 751585005238 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585005239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585005240 metal binding site [ion binding]; metal-binding site 751585005241 active site 751585005242 I-site; other site 751585005243 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 751585005244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585005245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585005246 metal binding site [ion binding]; metal-binding site 751585005247 active site 751585005248 I-site; other site 751585005249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 751585005250 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 751585005251 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 751585005252 heterodimer interface [polypeptide binding]; other site 751585005253 active site 751585005254 FMN binding site [chemical binding]; other site 751585005255 homodimer interface [polypeptide binding]; other site 751585005256 substrate binding site [chemical binding]; other site 751585005257 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 751585005258 active site 751585005259 dimer interface [polypeptide binding]; other site 751585005260 Chorismate mutase type II; Region: CM_2; smart00830 751585005261 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 751585005262 Predicted integral membrane protein [Function unknown]; Region: COG5652 751585005263 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 751585005264 Rubredoxin; Region: Rubredoxin; pfam00301 751585005265 iron binding site [ion binding]; other site 751585005266 Rubrerythrin [Energy production and conversion]; Region: COG1592 751585005267 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 751585005268 diiron binding motif [ion binding]; other site 751585005269 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 751585005270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 751585005271 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 751585005272 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 751585005273 Acylphosphatase; Region: Acylphosphatase; pfam00708 751585005274 dihydroorotase; Validated; Region: pyrC; PRK09357 751585005275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 751585005276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 751585005277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 751585005278 active site 751585005279 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 751585005280 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 751585005281 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 751585005282 Predicted membrane protein [Function unknown]; Region: COG4709 751585005283 Predicted transcriptional regulators [Transcription]; Region: COG1695 751585005284 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 751585005285 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 751585005286 active site 751585005287 catalytic residues [active] 751585005288 Quinolinate synthetase A protein; Region: NadA; pfam02445 751585005289 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 751585005290 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 751585005291 dimerization interface [polypeptide binding]; other site 751585005292 active site 751585005293 L-aspartate oxidase; Provisional; Region: PRK06175 751585005294 FAD binding domain; Region: FAD_binding_2; pfam00890 751585005295 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 751585005296 active site 751585005297 catalytic residues [active] 751585005298 metal binding site [ion binding]; metal-binding site 751585005299 Methyltransferase domain; Region: Methyltransf_23; pfam13489 751585005300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585005301 S-adenosylmethionine binding site [chemical binding]; other site 751585005302 hypothetical protein; Validated; Region: PRK00124 751585005303 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 751585005304 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 751585005305 Helix-turn-helix domain; Region: HTH_17; cl17695 751585005306 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 751585005307 Int/Topo IB signature motif; other site 751585005308 Sulfatase; Region: Sulfatase; cl17466 751585005309 methionine aminopeptidase; Provisional; Region: PRK12318 751585005310 SEC-C motif; Region: SEC-C; pfam02810 751585005311 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 751585005312 active site 751585005313 heat shock protein 90; Provisional; Region: PRK05218 751585005314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585005315 ATP binding site [chemical binding]; other site 751585005316 Mg2+ binding site [ion binding]; other site 751585005317 G-X-G motif; other site 751585005318 glycogen synthase; Provisional; Region: glgA; PRK00654 751585005319 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 751585005320 ADP-binding pocket [chemical binding]; other site 751585005321 homodimer interface [polypeptide binding]; other site 751585005322 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 751585005323 Domain of unknown function (DUF814); Region: DUF814; pfam05670 751585005324 hypothetical protein; Provisional; Region: PRK11820 751585005325 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 751585005326 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 751585005327 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 751585005328 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 751585005329 catalytic site [active] 751585005330 G-X2-G-X-G-K; other site 751585005331 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 751585005332 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 751585005333 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 751585005334 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 751585005335 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 751585005336 primosome assembly protein PriA; Validated; Region: PRK05580 751585005337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 751585005338 ATP binding site [chemical binding]; other site 751585005339 putative Mg++ binding site [ion binding]; other site 751585005340 helicase superfamily c-terminal domain; Region: HELICc; smart00490 751585005341 ATP-binding site [chemical binding]; other site 751585005342 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 751585005343 active site 751585005344 catalytic residues [active] 751585005345 metal binding site [ion binding]; metal-binding site 751585005346 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 751585005347 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 751585005348 substrate binding site [chemical binding]; other site 751585005349 16S rRNA methyltransferase B; Provisional; Region: PRK14902 751585005350 NusB family; Region: NusB; pfam01029 751585005351 putative RNA binding site [nucleotide binding]; other site 751585005352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585005353 S-adenosylmethionine binding site [chemical binding]; other site 751585005354 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 751585005355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585005356 FeS/SAM binding site; other site 751585005357 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 751585005358 active site 751585005359 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 751585005360 Catalytic domain of Protein Kinases; Region: PKc; cd00180 751585005361 active site 751585005362 ATP binding site [chemical binding]; other site 751585005363 substrate binding site [chemical binding]; other site 751585005364 activation loop (A-loop); other site 751585005365 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 751585005366 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 751585005367 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 751585005368 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 751585005369 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 751585005370 substrate binding site [chemical binding]; other site 751585005371 hexamer interface [polypeptide binding]; other site 751585005372 metal binding site [ion binding]; metal-binding site 751585005373 Thiamine pyrophosphokinase; Region: TPK; cd07995 751585005374 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 751585005375 active site 751585005376 dimerization interface [polypeptide binding]; other site 751585005377 thiamine binding site [chemical binding]; other site 751585005378 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 751585005379 Na binding site [ion binding]; other site 751585005380 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 751585005381 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 751585005382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585005383 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 751585005384 active site 751585005385 motif I; other site 751585005386 motif II; other site 751585005387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 751585005388 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 751585005389 putative nucleotide binding site [chemical binding]; other site 751585005390 uridine monophosphate binding site [chemical binding]; other site 751585005391 homohexameric interface [polypeptide binding]; other site 751585005392 ribosome recycling factor; Reviewed; Region: frr; PRK00083 751585005393 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 751585005394 hinge region; other site 751585005395 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 751585005396 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 751585005397 catalytic residue [active] 751585005398 putative FPP diphosphate binding site; other site 751585005399 putative FPP binding hydrophobic cleft; other site 751585005400 dimer interface [polypeptide binding]; other site 751585005401 putative IPP diphosphate binding site; other site 751585005402 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 751585005403 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 751585005404 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 751585005405 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 751585005406 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 751585005407 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 751585005408 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 751585005409 GcpE protein; Region: GcpE; pfam04551 751585005410 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 751585005411 DNA polymerase III PolC; Validated; Region: polC; PRK00448 751585005412 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 751585005413 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 751585005414 generic binding surface II; other site 751585005415 generic binding surface I; other site 751585005416 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 751585005417 active site 751585005418 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 751585005419 active site 751585005420 catalytic site [active] 751585005421 substrate binding site [chemical binding]; other site 751585005422 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 751585005423 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 751585005424 Stage II sporulation protein; Region: SpoIID; pfam08486 751585005425 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 751585005426 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 751585005427 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 751585005428 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 751585005429 putative RNA binding cleft [nucleotide binding]; other site 751585005430 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 751585005431 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 751585005432 DHH family; Region: DHH; pfam01368 751585005433 DHHA1 domain; Region: DHHA1; pfam02272 751585005434 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 751585005435 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 751585005436 RNA binding site [nucleotide binding]; other site 751585005437 active site 751585005438 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 751585005439 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 751585005440 active site 751585005441 Riboflavin kinase; Region: Flavokinase; pfam01687 751585005442 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 751585005443 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 751585005444 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 751585005445 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 751585005446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 751585005447 MarR family; Region: MarR; pfam01047 751585005448 MarR family; Region: MarR_2; cl17246 751585005449 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 751585005450 Predicted membrane protein [Function unknown]; Region: COG2364 751585005451 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 751585005452 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 751585005453 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 751585005454 signal recognition particle protein; Provisional; Region: PRK10867 751585005455 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 751585005456 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 751585005457 P loop; other site 751585005458 GTP binding site [chemical binding]; other site 751585005459 Signal peptide binding domain; Region: SRP_SPB; pfam02978 751585005460 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 751585005461 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 751585005462 hypothetical protein; Provisional; Region: PRK00468 751585005463 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 751585005464 RimM N-terminal domain; Region: RimM; pfam01782 751585005465 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 751585005466 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 751585005467 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 751585005468 CAP-like domain; other site 751585005469 active site 751585005470 primary dimer interface [polypeptide binding]; other site 751585005471 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 751585005472 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 751585005473 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 751585005474 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 751585005475 putative active site [active] 751585005476 oxyanion strand; other site 751585005477 catalytic triad [active] 751585005478 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 751585005479 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 751585005480 substrate binding site [chemical binding]; other site 751585005481 glutamase interaction surface [polypeptide binding]; other site 751585005482 putative transposase OrfB; Reviewed; Region: PHA02517 751585005483 HTH-like domain; Region: HTH_21; pfam13276 751585005484 Integrase core domain; Region: rve; pfam00665 751585005485 Integrase core domain; Region: rve_3; pfam13683 751585005486 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 751585005487 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 751585005488 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 751585005489 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 751585005490 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 751585005491 Rhomboid family; Region: Rhomboid; cl11446 751585005492 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 751585005493 Uncharacterized conserved protein [Function unknown]; Region: COG3874 751585005494 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 751585005495 Asp23 family; Region: Asp23; pfam03780 751585005496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 751585005497 nucleotide binding region [chemical binding]; other site 751585005498 ATP-binding site [chemical binding]; other site 751585005499 CBD_II domain; Region: CBD_II; smart00637 751585005500 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 751585005501 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 751585005502 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 751585005503 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 751585005504 dimer interface [polypeptide binding]; other site 751585005505 ADP-ribose binding site [chemical binding]; other site 751585005506 active site 751585005507 nudix motif; other site 751585005508 metal binding site [ion binding]; metal-binding site 751585005509 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 751585005510 16S/18S rRNA binding site [nucleotide binding]; other site 751585005511 S13e-L30e interaction site [polypeptide binding]; other site 751585005512 25S rRNA binding site [nucleotide binding]; other site 751585005513 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 751585005514 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 751585005515 catalytic domain interface [polypeptide binding]; other site 751585005516 putative homodimer interface [polypeptide binding]; other site 751585005517 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 751585005518 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 751585005519 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 751585005520 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 751585005521 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 751585005522 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 751585005523 Potassium binding sites [ion binding]; other site 751585005524 Cesium cation binding sites [ion binding]; other site 751585005525 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 751585005526 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 751585005527 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 751585005528 homodimer interface [polypeptide binding]; other site 751585005529 NADP binding site [chemical binding]; other site 751585005530 substrate binding site [chemical binding]; other site 751585005531 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 751585005532 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 751585005533 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 751585005534 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 751585005535 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 751585005536 carboxyltransferase (CT) interaction site; other site 751585005537 biotinylation site [posttranslational modification]; other site 751585005538 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 751585005539 oxaloacetate decarboxylase; Provisional; Region: PRK12331 751585005540 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 751585005541 active site 751585005542 catalytic residues [active] 751585005543 metal binding site [ion binding]; metal-binding site 751585005544 homodimer binding site [polypeptide binding]; other site 751585005545 RNase_H superfamily; Region: RNase_H_2; pfam13482 751585005546 active site 751585005547 catalytic site [active] 751585005548 substrate binding site [chemical binding]; other site 751585005549 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 751585005550 RuvA N terminal domain; Region: RuvA_N; pfam01330 751585005551 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 751585005552 Cell division protein ZapA; Region: ZapA; pfam05164 751585005553 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 751585005554 Peptidase family U32; Region: Peptidase_U32; pfam01136 751585005555 Collagenase; Region: DUF3656; pfam12392 751585005556 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 751585005557 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 751585005558 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 751585005559 active site 751585005560 catalytic site [active] 751585005561 four helix bundle protein; Region: TIGR02436 751585005562 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 751585005563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 751585005564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 751585005565 DNA binding residues [nucleotide binding] 751585005566 archaetidylserine synthase; Region: archae_ser_T; TIGR04217 751585005567 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 751585005568 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 751585005569 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 751585005570 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 751585005571 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 751585005572 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 751585005573 synthetase active site [active] 751585005574 NTP binding site [chemical binding]; other site 751585005575 metal binding site [ion binding]; metal-binding site 751585005576 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 751585005577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 751585005578 S-adenosylmethionine binding site [chemical binding]; other site 751585005579 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 751585005580 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 751585005581 classical (c) SDRs; Region: SDR_c; cd05233 751585005582 NAD(P) binding site [chemical binding]; other site 751585005583 active site 751585005584 Recombination protein U; Region: RecU; cl01314 751585005585 histidinol dehydrogenase; Region: hisD; TIGR00069 751585005586 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 751585005587 NAD binding site [chemical binding]; other site 751585005588 dimerization interface [polypeptide binding]; other site 751585005589 product binding site; other site 751585005590 substrate binding site [chemical binding]; other site 751585005591 zinc binding site [ion binding]; other site 751585005592 catalytic residues [active] 751585005593 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 751585005594 putative active site pocket [active] 751585005595 4-fold oligomerization interface [polypeptide binding]; other site 751585005596 metal binding residues [ion binding]; metal-binding site 751585005597 3-fold/trimer interface [polypeptide binding]; other site 751585005598 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 751585005599 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 751585005600 phosphate binding site [ion binding]; other site 751585005601 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 751585005602 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 751585005603 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 751585005604 metal binding site [ion binding]; metal-binding site 751585005605 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 751585005606 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 751585005607 motif 1; other site 751585005608 active site 751585005609 motif 2; other site 751585005610 motif 3; other site 751585005611 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 751585005612 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 751585005613 YabP family; Region: YabP; pfam07873 751585005614 metal-binding heat shock protein; Provisional; Region: PRK00016 751585005615 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 751585005616 flavoprotein, HI0933 family; Region: TIGR00275 751585005617 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 751585005618 gamma-glutamyl kinase; Provisional; Region: PRK05429 751585005619 nucleotide binding site [chemical binding]; other site 751585005620 homotetrameric interface [polypeptide binding]; other site 751585005621 putative phosphate binding site [ion binding]; other site 751585005622 putative allosteric binding site; other site 751585005623 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 751585005624 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 751585005625 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 751585005626 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 751585005627 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 751585005628 active site 751585005629 nucleophile elbow; other site 751585005630 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 751585005631 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 751585005632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585005633 FeS/SAM binding site; other site 751585005634 TRAM domain; Region: TRAM; pfam01938 751585005635 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 751585005636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585005637 ATP binding site [chemical binding]; other site 751585005638 Mg2+ binding site [ion binding]; other site 751585005639 G-X-G motif; other site 751585005640 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 751585005641 ATP binding site [chemical binding]; other site 751585005642 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 751585005643 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 751585005644 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 751585005645 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 751585005646 Aluminium resistance protein; Region: Alum_res; pfam06838 751585005647 hypothetical protein; Reviewed; Region: PRK00024 751585005648 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 751585005649 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 751585005650 MPN+ (JAMM) motif; other site 751585005651 Zinc-binding site [ion binding]; other site 751585005652 rod shape-determining protein MreC; Provisional; Region: PRK13922 751585005653 Prp19/Pso4-like; Region: Prp19; pfam08606 751585005654 rod shape-determining protein MreC; Region: MreC; pfam04085 751585005655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 751585005656 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 751585005657 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 751585005658 septum site-determining protein MinD; Region: minD_bact; TIGR01968 751585005659 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 751585005660 Switch I; other site 751585005661 Switch II; other site 751585005662 Septum formation topological specificity factor MinE; Region: MinE; cl00538 751585005663 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 751585005664 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 751585005665 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 751585005666 HlyD family secretion protein; Region: HlyD_2; pfam12700 751585005667 HlyD family secretion protein; Region: HlyD_2; pfam12700 751585005668 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 751585005669 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 751585005670 catalytic residue [active] 751585005671 Protein of unknown function (DUF552); Region: DUF552; pfam04472 751585005672 DivIVA protein; Region: DivIVA; pfam05103 751585005673 DivIVA domain; Region: DivI1A_domain; TIGR03544 751585005674 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 751585005675 active site 751585005676 dimer interface [polypeptide binding]; other site 751585005677 metal binding site [ion binding]; metal-binding site 751585005678 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 751585005679 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 751585005680 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 751585005681 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 751585005682 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 751585005683 Zn2+ binding site [ion binding]; other site 751585005684 Mg2+ binding site [ion binding]; other site 751585005685 Oligomerisation domain; Region: Oligomerisation; cl00519 751585005686 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 751585005687 Protein of unknown function (DUF464); Region: DUF464; pfam04327 751585005688 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 751585005689 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 751585005690 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 751585005691 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 751585005692 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 751585005693 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 751585005694 threonine dehydratase; Provisional; Region: PRK08198 751585005695 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 751585005696 tetramer interface [polypeptide binding]; other site 751585005697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 751585005698 catalytic residue [active] 751585005699 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 751585005700 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 751585005701 AAA domain; Region: AAA_23; pfam13476 751585005702 Walker A/P-loop; other site 751585005703 ATP binding site [chemical binding]; other site 751585005704 Q-loop/lid; other site 751585005705 ribonuclease III; Reviewed; Region: rnc; PRK00102 751585005706 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 751585005707 dimerization interface [polypeptide binding]; other site 751585005708 active site 751585005709 metal binding site [ion binding]; metal-binding site 751585005710 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 751585005711 dsRNA binding site [nucleotide binding]; other site 751585005712 putative phosphate acyltransferase; Provisional; Region: PRK05331 751585005713 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 751585005714 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 751585005715 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 751585005716 dephospho-CoA kinase; Region: TIGR00152 751585005717 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 751585005718 CoA-binding site [chemical binding]; other site 751585005719 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 751585005720 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 751585005721 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 751585005722 ketol-acid reductoisomerase; Provisional; Region: PRK05479 751585005723 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 751585005724 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 751585005725 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 751585005726 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 751585005727 putative valine binding site [chemical binding]; other site 751585005728 dimer interface [polypeptide binding]; other site 751585005729 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 751585005730 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 751585005731 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 751585005732 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 751585005733 substrate binding pocket [chemical binding]; other site 751585005734 dimer interface [polypeptide binding]; other site 751585005735 inhibitor binding site; inhibition site 751585005736 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 751585005737 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 751585005738 B12 binding site [chemical binding]; other site 751585005739 cobalt ligand [ion binding]; other site 751585005740 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 751585005741 RNA/DNA hybrid binding site [nucleotide binding]; other site 751585005742 active site 751585005743 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 751585005744 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 751585005745 active site 751585005746 metal binding site [ion binding]; metal-binding site 751585005747 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 751585005748 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 751585005749 DivIVA protein; Region: DivIVA; pfam05103 751585005750 DivIVA domain; Region: DivI1A_domain; TIGR03544 751585005751 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 751585005752 putative active site [active] 751585005753 dimerization interface [polypeptide binding]; other site 751585005754 putative tRNAtyr binding site [nucleotide binding]; other site 751585005755 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585005756 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_9; cd13135 751585005757 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 751585005758 active site 751585005759 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 751585005760 dimer interface [polypeptide binding]; other site 751585005761 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 751585005762 Ligand Binding Site [chemical binding]; other site 751585005763 Molecular Tunnel; other site 751585005764 HipA-like N-terminal domain; Region: HipA_N; pfam07805 751585005765 HipA-like C-terminal domain; Region: HipA_C; pfam07804 751585005766 HipA N-terminal domain; Region: couple_hipA; TIGR03071 751585005767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585005768 non-specific DNA binding site [nucleotide binding]; other site 751585005769 salt bridge; other site 751585005770 sequence-specific DNA binding site [nucleotide binding]; other site 751585005771 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 751585005772 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 751585005773 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 751585005774 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 751585005775 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 751585005776 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 751585005777 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 751585005778 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 751585005779 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 751585005780 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 751585005781 GTP-binding protein Der; Reviewed; Region: PRK00093 751585005782 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 751585005783 G1 box; other site 751585005784 GTP/Mg2+ binding site [chemical binding]; other site 751585005785 Switch I region; other site 751585005786 G2 box; other site 751585005787 Switch II region; other site 751585005788 G3 box; other site 751585005789 G4 box; other site 751585005790 G5 box; other site 751585005791 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 751585005792 G1 box; other site 751585005793 GTP/Mg2+ binding site [chemical binding]; other site 751585005794 Switch I region; other site 751585005795 G2 box; other site 751585005796 G3 box; other site 751585005797 Switch II region; other site 751585005798 G4 box; other site 751585005799 G5 box; other site 751585005800 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 751585005801 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 751585005802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 751585005803 Protein of unknown function (DUF512); Region: DUF512; pfam04459 751585005804 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 751585005805 hypothetical protein; Reviewed; Region: PRK12497 751585005806 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 751585005807 RNA/DNA hybrid binding site [nucleotide binding]; other site 751585005808 active site 751585005809 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 751585005810 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 751585005811 Catalytic site [active] 751585005812 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 751585005813 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 751585005814 GTP/Mg2+ binding site [chemical binding]; other site 751585005815 G4 box; other site 751585005816 G5 box; other site 751585005817 G1 box; other site 751585005818 Switch I region; other site 751585005819 G2 box; other site 751585005820 G3 box; other site 751585005821 Switch II region; other site 751585005822 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 751585005823 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 751585005824 Catalytic site [active] 751585005825 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 751585005826 RNA binding site [nucleotide binding]; other site 751585005827 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 751585005828 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 751585005829 RNB domain; Region: RNB; pfam00773 751585005830 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 751585005831 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 751585005832 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 751585005833 phosphoglyceromutase; Provisional; Region: PRK05434 751585005834 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 751585005835 Phosphoglycerate kinase; Region: PGK; pfam00162 751585005836 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 751585005837 substrate binding site [chemical binding]; other site 751585005838 hinge regions; other site 751585005839 ADP binding site [chemical binding]; other site 751585005840 catalytic site [active] 751585005841 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 751585005842 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 751585005843 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 751585005844 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 751585005845 catalytic residue [active] 751585005846 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 751585005847 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 751585005848 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 751585005849 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 751585005850 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 751585005851 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 751585005852 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 751585005853 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 751585005854 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 751585005855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 751585005856 substrate binding site [chemical binding]; other site 751585005857 oxyanion hole (OAH) forming residues; other site 751585005858 trimer interface [polypeptide binding]; other site 751585005859 rod shape-determining protein MreB; Provisional; Region: PRK13930 751585005860 MreB and similar proteins; Region: MreB_like; cd10225 751585005861 nucleotide binding site [chemical binding]; other site 751585005862 Mg binding site [ion binding]; other site 751585005863 putative protofilament interaction site [polypeptide binding]; other site 751585005864 RodZ interaction site [polypeptide binding]; other site 751585005865 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 751585005866 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 751585005867 folate binding site [chemical binding]; other site 751585005868 NADP+ binding site [chemical binding]; other site 751585005869 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 751585005870 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 751585005871 dimerization interface [polypeptide binding]; other site 751585005872 active site 751585005873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585005874 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585005875 non-specific DNA binding site [nucleotide binding]; other site 751585005876 salt bridge; other site 751585005877 sequence-specific DNA binding site [nucleotide binding]; other site 751585005878 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 751585005879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 751585005880 non-specific DNA binding site [nucleotide binding]; other site 751585005881 salt bridge; other site 751585005882 sequence-specific DNA binding site [nucleotide binding]; other site 751585005883 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 751585005884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585005885 FeS/SAM binding site; other site 751585005886 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 751585005887 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 751585005888 DRTGG domain; Region: DRTGG; pfam07085 751585005889 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 751585005890 DHHA2 domain; Region: DHHA2; pfam02833 751585005891 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 751585005892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 751585005893 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 751585005894 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 751585005895 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 751585005896 ATP-grasp domain; Region: ATP-grasp_4; cl17255 751585005897 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 751585005898 IMP binding site; other site 751585005899 dimer interface [polypeptide binding]; other site 751585005900 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 751585005901 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 751585005902 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 751585005903 catalytic site [active] 751585005904 subunit interface [polypeptide binding]; other site 751585005905 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 751585005906 argininosuccinate lyase; Provisional; Region: PRK00855 751585005907 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 751585005908 active sites [active] 751585005909 tetramer interface [polypeptide binding]; other site 751585005910 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 751585005911 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 751585005912 G1 box; other site 751585005913 putative GEF interaction site [polypeptide binding]; other site 751585005914 GTP/Mg2+ binding site [chemical binding]; other site 751585005915 Switch I region; other site 751585005916 G2 box; other site 751585005917 G3 box; other site 751585005918 Switch II region; other site 751585005919 G4 box; other site 751585005920 G5 box; other site 751585005921 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 751585005922 Helix-turn-helix domain; Region: HTH_31; pfam13560 751585005923 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 751585005924 putative metal binding site [ion binding]; other site 751585005925 Uncharacterized conserved protein [Function unknown]; Region: COG1432 751585005926 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 751585005927 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 751585005928 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 751585005929 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 751585005930 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 751585005931 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 751585005932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 751585005933 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 751585005934 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 751585005935 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 751585005936 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 751585005937 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 751585005938 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 751585005939 DXD motif; other site 751585005940 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 751585005941 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 751585005942 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 751585005943 hinge residues; other site 751585005944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 751585005945 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 751585005946 substrate binding pocket [chemical binding]; other site 751585005947 membrane-bound complex binding site; other site 751585005948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 751585005949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 751585005950 putative PBP binding loops; other site 751585005951 dimer interface [polypeptide binding]; other site 751585005952 ABC-ATPase subunit interface; other site 751585005953 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 751585005954 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 751585005955 Penicillinase repressor; Region: Pencillinase_R; pfam03965 751585005956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 751585005957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 751585005958 Coenzyme A binding pocket [chemical binding]; other site 751585005959 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 751585005960 FtsX-like permease family; Region: FtsX; pfam02687 751585005961 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 751585005962 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 751585005963 Walker A/P-loop; other site 751585005964 ATP binding site [chemical binding]; other site 751585005965 Q-loop/lid; other site 751585005966 ABC transporter signature motif; other site 751585005967 Walker B; other site 751585005968 D-loop; other site 751585005969 H-loop/switch region; other site 751585005970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 751585005971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585005972 active site 751585005973 phosphorylation site [posttranslational modification] 751585005974 intermolecular recognition site; other site 751585005975 dimerization interface [polypeptide binding]; other site 751585005976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 751585005977 DNA binding site [nucleotide binding] 751585005978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 751585005979 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 751585005980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 751585005981 FeS/SAM binding site; other site 751585005982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 751585005983 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 751585005984 ligand binding site [chemical binding]; other site 751585005985 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 751585005986 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 751585005987 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 751585005988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585005989 Walker A motif; other site 751585005990 ATP binding site [chemical binding]; other site 751585005991 Walker B motif; other site 751585005992 arginine finger; other site 751585005993 Peptidase family M41; Region: Peptidase_M41; pfam01434 751585005994 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 751585005995 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 751585005996 Thg1 C terminal domain; Region: Thg1C; pfam14413 751585005997 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 751585005998 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 751585005999 Cation efflux family; Region: Cation_efflux; cl00316 751585006000 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 751585006001 Divergent AAA domain; Region: AAA_4; pfam04326 751585006002 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 751585006003 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 751585006004 non-specific DNA interactions [nucleotide binding]; other site 751585006005 DNA binding site [nucleotide binding] 751585006006 sequence specific DNA binding site [nucleotide binding]; other site 751585006007 putative cAMP binding site [chemical binding]; other site 751585006008 glutamyl-tRNA reductase; Provisional; Region: PRK13940 751585006009 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 751585006010 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 751585006011 Walker A motif; other site 751585006012 ATP binding site [chemical binding]; other site 751585006013 Walker B motif; other site 751585006014 CHAT domain; Region: CHAT; pfam12770 751585006015 Gap junction channel protein cysteine-rich domain; Region: Connexin_CCC; cl11207 751585006016 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 751585006017 DNA repair protein RadA; Provisional; Region: PRK11823 751585006018 Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]; Region: Sms; COG1066 751585006019 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 751585006020 Walker A motif/ATP binding site; other site 751585006021 ATP binding site [chemical binding]; other site 751585006022 Walker B motif; other site 751585006023 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 751585006024 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 751585006025 Clp amino terminal domain; Region: Clp_N; pfam02861 751585006026 Clp amino terminal domain; Region: Clp_N; pfam02861 751585006027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585006028 Walker A motif; other site 751585006029 ATP binding site [chemical binding]; other site 751585006030 Walker B motif; other site 751585006031 arginine finger; other site 751585006032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 751585006033 Walker A motif; other site 751585006034 ATP binding site [chemical binding]; other site 751585006035 Walker B motif; other site 751585006036 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 751585006037 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 751585006038 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 751585006039 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 751585006040 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 751585006041 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 751585006042 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 751585006043 active site 751585006044 substrate binding site [chemical binding]; other site 751585006045 cosubstrate binding site; other site 751585006046 catalytic site [active] 751585006047 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 751585006048 dimerization interface [polypeptide binding]; other site 751585006049 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 751585006050 ligand binding site [chemical binding]; other site 751585006051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 751585006052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 751585006053 metal binding site [ion binding]; metal-binding site 751585006054 active site 751585006055 I-site; other site 751585006056 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 751585006057 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 751585006058 Flavoprotein; Region: Flavoprotein; pfam02441 751585006059 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 751585006060 pantoate--beta-alanine ligase; Region: panC; TIGR00018 751585006061 Pantoate-beta-alanine ligase; Region: PanC; cd00560 751585006062 active site 751585006063 ATP-binding site [chemical binding]; other site 751585006064 pantoate-binding site; other site 751585006065 HXXH motif; other site 751585006066 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 751585006067 oligomerization interface [polypeptide binding]; other site 751585006068 active site 751585006069 metal binding site [ion binding]; metal-binding site 751585006070 Uncharacterized conserved protein [Function unknown]; Region: COG5495 751585006071 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 751585006072 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 751585006073 AIR carboxylase; Region: AIRC; pfam00731 751585006074 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 751585006075 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 751585006076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 751585006077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 751585006078 dimer interface [polypeptide binding]; other site 751585006079 phosphorylation site [posttranslational modification] 751585006080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 751585006081 ATP binding site [chemical binding]; other site 751585006082 G-X-G motif; other site 751585006083 Response regulator receiver domain; Region: Response_reg; pfam00072 751585006084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 751585006085 active site 751585006086 phosphorylation site [posttranslational modification] 751585006087 intermolecular recognition site; other site 751585006088 dimerization interface [polypeptide binding]; other site 751585006089 Hpt domain; Region: Hpt; pfam01627 751585006090 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 751585006091 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 751585006092 oligomer interface [polypeptide binding]; other site 751585006093 putative active site [active] 751585006094 metal binding site [ion binding]; metal-binding site 751585006095 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 751585006096 Part of AAA domain; Region: AAA_19; pfam13245 751585006097 Family description; Region: UvrD_C_2; pfam13538 751585006098 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 751585006099 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 751585006100 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 751585006101 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 751585006102 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 751585006103 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 751585006104 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 751585006105 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 751585006106 active site 751585006107 metal binding site [ion binding]; metal-binding site 751585006108 Competence-damaged protein; Region: CinA; pfam02464