-- dump date   	20140619_050140
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
717962000001	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
717962000002	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
717962000003	Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304
717962000004	ligand binding site [chemical binding]; other site
717962000005	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
717962000006	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717962000007	Walker A/P-loop; other site
717962000008	ATP binding site [chemical binding]; other site
717962000009	Q-loop/lid; other site
717962000010	ABC transporter signature motif; other site
717962000011	Walker B; other site
717962000012	D-loop; other site
717962000013	H-loop/switch region; other site
717962000014	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717962000015	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962000016	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717962000017	TM-ABC transporter signature motif; other site
717962000018	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962000019	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717962000020	TM-ABC transporter signature motif; other site
717962000021	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962000022	guanine deaminase; Region: guan_deamin; TIGR02967
717962000023	active site
717962000024	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
717962000025	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
717962000026	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
717962000027	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09644
717962000028	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
717962000029	tetramer interface [polypeptide binding]; other site
717962000030	putative DNA binding site [nucleotide binding]; other site
717962000031	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
717962000032	Mrr N-terminal domain; Region: Mrr_N; pfam14338
717962000033	Restriction endonuclease; Region: Mrr_cat; pfam04471
717962000034	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
717962000035	ArsC family; Region: ArsC; pfam03960
717962000036	catalytic residue [active]
717962000037	Transglutaminase/protease-like homologues; Region: TGc; smart00460
717962000038	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962000039	PAS domain; Region: PAS; smart00091
717962000040	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717962000041	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
717962000042	active site
717962000043	catalytic tetrad [active]
717962000044	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
717962000045	TrkA-N domain; Region: TrkA_N; pfam02254
717962000046	TrkA-C domain; Region: TrkA_C; pfam02080
717962000047	TrkA-N domain; Region: TrkA_N; pfam02254
717962000048	TrkA-C domain; Region: TrkA_C; pfam02080
717962000049	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
717962000050	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
717962000051	galactokinase; Provisional; Region: PRK05322
717962000052	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
717962000053	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
717962000054	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
717962000055	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
717962000056	UDP-glucose 4-epimerase; Region: PLN02240
717962000057	NAD binding site [chemical binding]; other site
717962000058	homodimer interface [polypeptide binding]; other site
717962000059	active site
717962000060	substrate binding site [chemical binding]; other site
717962000061	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
717962000062	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
717962000063	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
717962000064	putative ligand binding site [chemical binding]; other site
717962000065	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
717962000066	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717962000067	Walker A/P-loop; other site
717962000068	ATP binding site [chemical binding]; other site
717962000069	Q-loop/lid; other site
717962000070	ABC transporter signature motif; other site
717962000071	Walker B; other site
717962000072	D-loop; other site
717962000073	H-loop/switch region; other site
717962000074	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717962000075	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962000076	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717962000077	TM-ABC transporter signature motif; other site
717962000078	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962000079	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717962000080	TM-ABC transporter signature motif; other site
717962000081	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
717962000082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962000083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962000084	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
717962000085	putative dimerization interface [polypeptide binding]; other site
717962000086	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
717962000087	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717962000088	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
717962000089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962000090	dimer interface [polypeptide binding]; other site
717962000091	conserved gate region; other site
717962000092	putative PBP binding loops; other site
717962000093	ABC-ATPase subunit interface; other site
717962000094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962000095	Walker A/P-loop; other site
717962000096	ATP binding site [chemical binding]; other site
717962000097	spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187
717962000098	Q-loop/lid; other site
717962000099	ABC transporter signature motif; other site
717962000100	Walker B; other site
717962000101	D-loop; other site
717962000102	H-loop/switch region; other site
717962000103	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
717962000104	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717962000105	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962000106	catalytic residue [active]
717962000107	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
717962000108	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
717962000109	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
717962000110	Peptidase family M23; Region: Peptidase_M23; pfam01551
717962000111	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
717962000112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717962000113	NAD(P) binding site [chemical binding]; other site
717962000114	active site
717962000115	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
717962000116	putative homodimer interface [polypeptide binding]; other site
717962000117	putative homotetramer interface [polypeptide binding]; other site
717962000118	putative allosteric switch controlling residues; other site
717962000119	putative metal binding site [ion binding]; other site
717962000120	putative homodimer-homodimer interface [polypeptide binding]; other site
717962000121	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
717962000122	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717962000123	metal-binding site [ion binding]
717962000124	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717962000125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962000126	motif II; other site
717962000127	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717962000128	metal-binding site [ion binding]
717962000129	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
717962000130	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
717962000131	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
717962000132	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
717962000133	C-terminal peptidase (prc); Region: prc; TIGR00225
717962000134	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
717962000135	protein binding site [polypeptide binding]; other site
717962000136	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
717962000137	Catalytic dyad [active]
717962000138	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
717962000139	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
717962000140	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717962000141	ATP-binding site [chemical binding]; other site
717962000142	ATP binding site [chemical binding]; other site
717962000143	TIR domain; Region: TIR_2; pfam13676
717962000144	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
717962000145	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
717962000146	excinuclease ABC subunit B; Provisional; Region: PRK05298
717962000147	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717962000148	ATP binding site [chemical binding]; other site
717962000149	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717962000150	nucleotide binding region [chemical binding]; other site
717962000151	ATP-binding site [chemical binding]; other site
717962000152	Ultra-violet resistance protein B; Region: UvrB; pfam12344
717962000153	UvrB/uvrC motif; Region: UVR; pfam02151
717962000154	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
717962000155	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
717962000156	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
717962000157	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
717962000158	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
717962000159	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
717962000160	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717962000161	ATP binding site [chemical binding]; other site
717962000162	putative Mg++ binding site [ion binding]; other site
717962000163	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717962000164	nucleotide binding region [chemical binding]; other site
717962000165	ATP-binding site [chemical binding]; other site
717962000166	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
717962000167	CoA-transferase family III; Region: CoA_transf_3; pfam02515
717962000168	Predicted membrane protein [Function unknown]; Region: COG2364
717962000169	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962000170	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717962000171	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
717962000172	active site
717962000173	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717962000174	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717962000175	putative DNA binding site [nucleotide binding]; other site
717962000176	putative Zn2+ binding site [ion binding]; other site
717962000177	Germination protease; Region: Peptidase_A25; cl04057
717962000178	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962000179	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717962000180	Citrate transporter; Region: CitMHS; pfam03600
717962000181	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
717962000182	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962000183	active site
717962000184	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
717962000185	homodimer interaction site [polypeptide binding]; other site
717962000186	cofactor binding site; other site
717962000187	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
717962000188	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
717962000189	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
717962000190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962000191	Walker A motif; other site
717962000192	ATP binding site [chemical binding]; other site
717962000193	Walker B motif; other site
717962000194	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
717962000195	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962000196	ABC transporter; Region: ABC_tran_2; pfam12848
717962000197	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962000198	stage V sporulation protein AD; Validated; Region: PRK08304
717962000199	stage V sporulation protein AD; Provisional; Region: PRK12404
717962000200	RNA polymerase factor sigma-70; Validated; Region: PRK06811
717962000201	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962000202	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962000203	DNA binding residues [nucleotide binding]
717962000204	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717962000205	MarR family; Region: MarR; pfam01047
717962000206	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
717962000207	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717962000208	substrate binding site [chemical binding]; other site
717962000209	oxyanion hole (OAH) forming residues; other site
717962000210	trimer interface [polypeptide binding]; other site
717962000211	Citrate transporter; Region: CitMHS; pfam03600
717962000212	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
717962000213	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
717962000214	active site
717962000215	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
717962000216	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
717962000217	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
717962000218	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
717962000219	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
717962000220	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
717962000221	active site
717962000222	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
717962000223	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
717962000224	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
717962000225	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
717962000226	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
717962000227	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
717962000228	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962000229	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962000230	homodimer interface [polypeptide binding]; other site
717962000231	catalytic residue [active]
717962000232	transcription elongation factor GreA; Region: greA; TIGR01462
717962000233	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
717962000234	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
717962000235	SpoVA protein; Region: SpoVA; pfam03862
717962000236	Transglycosylase; Region: Transgly; pfam00912
717962000237	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
717962000238	Uncharacterized conserved protein [Function unknown]; Region: COG1739
717962000239	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
717962000240	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
717962000241	trigger factor; Region: tig; TIGR00115
717962000242	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
717962000243	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
717962000244	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
717962000245	Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761
717962000246	putative active site [active]
717962000247	putative metal binding residues [ion binding]; other site
717962000248	signature motif; other site
717962000249	putative dimer interface [polypeptide binding]; other site
717962000250	putative phosphate binding site [ion binding]; other site
717962000251	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
717962000252	EamA-like transporter family; Region: EamA; pfam00892
717962000253	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717962000254	trigger factor; Provisional; Region: tig; PRK01490
717962000255	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
717962000256	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
717962000257	Clp protease; Region: CLP_protease; pfam00574
717962000258	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
717962000259	oligomer interface [polypeptide binding]; other site
717962000260	active site residues [active]
717962000261	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
717962000262	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
717962000263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962000264	Walker A motif; other site
717962000265	ATP binding site [chemical binding]; other site
717962000266	Walker B motif; other site
717962000267	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
717962000268	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
717962000269	Found in ATP-dependent protease La (LON); Region: LON; smart00464
717962000270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962000271	Walker A motif; other site
717962000272	ATP binding site [chemical binding]; other site
717962000273	Walker B motif; other site
717962000274	arginine finger; other site
717962000275	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
717962000276	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
717962000277	G1 box; other site
717962000278	GTP/Mg2+ binding site [chemical binding]; other site
717962000279	Switch I region; other site
717962000280	G2 box; other site
717962000281	G3 box; other site
717962000282	Switch II region; other site
717962000283	G4 box; other site
717962000284	G5 box; other site
717962000285	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
717962000286	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
717962000287	Beta-Casp domain; Region: Beta-Casp; smart01027
717962000288	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
717962000289	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
717962000290	NTPase; Region: NTPase_1; cl17478
717962000291	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
717962000292	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
717962000293	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
717962000294	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
717962000295	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
717962000296	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
717962000297	Asp23 family; Region: Asp23; pfam03780
717962000298	transcription antitermination factor NusB; Region: nusB; TIGR01951
717962000299	putative RNA binding site [nucleotide binding]; other site
717962000300	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
717962000301	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
717962000302	generic binding surface II; other site
717962000303	generic binding surface I; other site
717962000304	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
717962000305	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
717962000306	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
717962000307	substrate binding pocket [chemical binding]; other site
717962000308	chain length determination region; other site
717962000309	substrate-Mg2+ binding site; other site
717962000310	catalytic residues [active]
717962000311	aspartate-rich region 1; other site
717962000312	active site lid residues [active]
717962000313	aspartate-rich region 2; other site
717962000314	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
717962000315	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
717962000316	TPP-binding site; other site
717962000317	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
717962000318	PYR/PP interface [polypeptide binding]; other site
717962000319	dimer interface [polypeptide binding]; other site
717962000320	TPP binding site [chemical binding]; other site
717962000321	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
717962000322	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
717962000323	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717962000324	RNA binding surface [nucleotide binding]; other site
717962000325	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
717962000326	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
717962000327	ATP-NAD kinase; Region: NAD_kinase; pfam01513
717962000328	arginine repressor; Provisional; Region: argR; PRK00441
717962000329	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
717962000330	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
717962000331	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
717962000332	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
717962000333	Walker A/P-loop; other site
717962000334	ATP binding site [chemical binding]; other site
717962000335	Q-loop/lid; other site
717962000336	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
717962000337	ABC transporter signature motif; other site
717962000338	Walker B; other site
717962000339	D-loop; other site
717962000340	H-loop/switch region; other site
717962000341	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
717962000342	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
717962000343	potassium/proton antiporter; Reviewed; Region: PRK05326
717962000344	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
717962000345	TrkA-C domain; Region: TrkA_C; pfam02080
717962000346	TrkA-C domain; Region: TrkA_C; pfam02080
717962000347	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
717962000348	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962000349	motif II; other site
717962000350	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
717962000351	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
717962000352	active site
717962000353	HIGH motif; other site
717962000354	dimer interface [polypeptide binding]; other site
717962000355	KMSKS motif; other site
717962000356	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717962000357	RNA binding surface [nucleotide binding]; other site
717962000358	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
717962000359	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
717962000360	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
717962000361	glycerate kinase; Region: TIGR00045
717962000362	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
717962000363	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
717962000364	NAD binding site [chemical binding]; other site
717962000365	ligand binding site [chemical binding]; other site
717962000366	catalytic site [active]
717962000367	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
717962000368	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
717962000369	dimer interface [polypeptide binding]; other site
717962000370	anticodon binding site; other site
717962000371	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
717962000372	motif 1; other site
717962000373	dimer interface [polypeptide binding]; other site
717962000374	active site
717962000375	motif 2; other site
717962000376	GAD domain; Region: GAD; pfam02938
717962000377	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
717962000378	active site
717962000379	motif 3; other site
717962000380	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717962000381	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962000382	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
717962000383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962000384	active site
717962000385	phosphorylation site [posttranslational modification]
717962000386	intermolecular recognition site; other site
717962000387	dimerization interface [polypeptide binding]; other site
717962000388	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
717962000389	glycogen synthase; Provisional; Region: glgA; PRK00654
717962000390	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
717962000391	ADP-binding pocket [chemical binding]; other site
717962000392	homodimer interface [polypeptide binding]; other site
717962000393	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
717962000394	glutamate dehydrogenase; Provisional; Region: PRK09414
717962000395	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
717962000396	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
717962000397	NAD(P) binding site [chemical binding]; other site
717962000398	transcription termination factor Rho; Provisional; Region: rho; PRK09376
717962000399	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
717962000400	RNA binding site [nucleotide binding]; other site
717962000401	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717962000402	Walker A motif; other site
717962000403	ATP binding site [chemical binding]; other site
717962000404	Walker B motif; other site
717962000405	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
717962000406	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
717962000407	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
717962000408	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962000409	S-adenosylmethionine binding site [chemical binding]; other site
717962000410	peptide chain release factor 1; Validated; Region: prfA; PRK00591
717962000411	This domain is found in peptide chain release factors; Region: PCRF; smart00937
717962000412	RF-1 domain; Region: RF-1; pfam00472
717962000413	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
717962000414	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
717962000415	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717962000416	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
717962000417	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962000418	motif II; other site
717962000419	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
717962000420	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962000421	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
717962000422	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717962000423	regulatory protein interface [polypeptide binding]; other site
717962000424	active site
717962000425	regulatory phosphorylation site [posttranslational modification]; other site
717962000426	Uncharacterized conserved protein [Function unknown]; Region: COG2966
717962000427	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
717962000428	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
717962000429	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
717962000430	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
717962000431	minor groove reading motif; other site
717962000432	helix-hairpin-helix signature motif; other site
717962000433	substrate binding pocket [chemical binding]; other site
717962000434	active site
717962000435	Fumble; Region: Fumble; cl17357
717962000436	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
717962000437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962000438	active site
717962000439	phosphorylation site [posttranslational modification]
717962000440	intermolecular recognition site; other site
717962000441	dimerization interface [polypeptide binding]; other site
717962000442	LytTr DNA-binding domain; Region: LytTR; pfam04397
717962000443	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962000444	ATP binding site [chemical binding]; other site
717962000445	Mg2+ binding site [ion binding]; other site
717962000446	G-X-G motif; other site
717962000447	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
717962000448	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
717962000449	active site
717962000450	zinc binding site [ion binding]; other site
717962000451	hypothetical protein; Provisional; Region: PRK04081
717962000452	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962000453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962000454	Walker A/P-loop; other site
717962000455	ATP binding site [chemical binding]; other site
717962000456	Q-loop/lid; other site
717962000457	ABC transporter signature motif; other site
717962000458	Walker B; other site
717962000459	D-loop; other site
717962000460	H-loop/switch region; other site
717962000461	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
717962000462	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962000463	Walker A/P-loop; other site
717962000464	ATP binding site [chemical binding]; other site
717962000465	Q-loop/lid; other site
717962000466	ABC transporter signature motif; other site
717962000467	Walker B; other site
717962000468	D-loop; other site
717962000469	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
717962000470	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
717962000471	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
717962000472	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962000473	DNA topoisomerase III; Provisional; Region: PRK07726
717962000474	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
717962000475	active site
717962000476	putative interdomain interaction site [polypeptide binding]; other site
717962000477	putative metal-binding site [ion binding]; other site
717962000478	putative nucleotide binding site [chemical binding]; other site
717962000479	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
717962000480	DNA binding groove [nucleotide binding]
717962000481	domain I; other site
717962000482	phosphate binding site [ion binding]; other site
717962000483	domain II; other site
717962000484	domain III; other site
717962000485	nucleotide binding site [chemical binding]; other site
717962000486	catalytic site [active]
717962000487	domain IV; other site
717962000488	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
717962000489	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
717962000490	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
717962000491	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
717962000492	active site
717962000493	nucleophile elbow; other site
717962000494	putative phosphoesterase; Region: acc_ester; TIGR03729
717962000495	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717962000496	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
717962000497	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
717962000498	putative oligomer interface [polypeptide binding]; other site
717962000499	putative active site [active]
717962000500	metal binding site [ion binding]; metal-binding site
717962000501	methionine aminopeptidase; Provisional; Region: PRK12318
717962000502	SEC-C motif; Region: SEC-C; pfam02810
717962000503	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
717962000504	active site
717962000505	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
717962000506	CTP synthetase; Validated; Region: pyrG; PRK05380
717962000507	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
717962000508	Catalytic site [active]
717962000509	active site
717962000510	UTP binding site [chemical binding]; other site
717962000511	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
717962000512	active site
717962000513	putative oxyanion hole; other site
717962000514	catalytic triad [active]
717962000515	FtsH Extracellular; Region: FtsH_ext; pfam06480
717962000516	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
717962000517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962000518	Walker A motif; other site
717962000519	ATP binding site [chemical binding]; other site
717962000520	Walker B motif; other site
717962000521	arginine finger; other site
717962000522	Peptidase family M41; Region: Peptidase_M41; pfam01434
717962000523	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
717962000524	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
717962000525	GIY-YIG motif/motif A; other site
717962000526	active site
717962000527	catalytic site [active]
717962000528	putative DNA binding site [nucleotide binding]; other site
717962000529	metal binding site [ion binding]; metal-binding site
717962000530	UvrB/uvrC motif; Region: UVR; pfam02151
717962000531	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
717962000532	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
717962000533	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
717962000534	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
717962000535	Hpr binding site; other site
717962000536	active site
717962000537	homohexamer subunit interaction site [polypeptide binding]; other site
717962000538	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
717962000539	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717962000540	nucleotide binding site [chemical binding]; other site
717962000541	Glucokinase; Region: Glucokinase; cl17310
717962000542	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
717962000543	FAD binding domain; Region: FAD_binding_4; pfam01565
717962000544	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
717962000545	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
717962000546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
717962000547	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
717962000548	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717962000549	dimerization domain swap beta strand [polypeptide binding]; other site
717962000550	regulatory protein interface [polypeptide binding]; other site
717962000551	active site
717962000552	regulatory phosphorylation site [posttranslational modification]; other site
717962000553	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
717962000554	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
717962000555	active site
717962000556	PHP Thumb interface [polypeptide binding]; other site
717962000557	metal binding site [ion binding]; metal-binding site
717962000558	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
717962000559	generic binding surface II; other site
717962000560	generic binding surface I; other site
717962000561	6-phosphofructokinase; Provisional; Region: PRK03202
717962000562	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
717962000563	active site
717962000564	ADP/pyrophosphate binding site [chemical binding]; other site
717962000565	dimerization interface [polypeptide binding]; other site
717962000566	allosteric effector site; other site
717962000567	fructose-1,6-bisphosphate binding site; other site
717962000568	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
717962000569	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
717962000570	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
717962000571	HflC protein; Region: hflC; TIGR01932
717962000572	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
717962000573	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
717962000574	active site
717962000575	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
717962000576	Biotin operon repressor [Transcription]; Region: BirA; COG1654
717962000577	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
717962000578	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
717962000579	pantothenate kinase; Reviewed; Region: PRK13318
717962000580	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
717962000581	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
717962000582	FMN binding site [chemical binding]; other site
717962000583	active site
717962000584	catalytic residues [active]
717962000585	substrate binding site [chemical binding]; other site
717962000586	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
717962000587	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
717962000588	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
717962000589	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
717962000590	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
717962000591	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
717962000592	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
717962000593	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
717962000594	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
717962000595	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
717962000596	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
717962000597	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
717962000598	ParB-like nuclease domain; Region: ParBc; pfam02195
717962000599	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
717962000600	Cna protein B-type domain; Region: Cna_B; pfam05738
717962000601	Cna protein B-type domain; Region: Cna_B; pfam05738
717962000602	Cna protein B-type domain; Region: Cna_B; pfam05738
717962000603	Cna protein B-type domain; Region: Cna_B; pfam05738
717962000604	Methyltransferase domain; Region: Methyltransf_26; pfam13659
717962000605	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
717962000606	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
717962000607	AAA domain; Region: AAA_25; pfam13481
717962000608	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717962000609	ATP binding site [chemical binding]; other site
717962000610	Walker A motif; other site
717962000611	Walker B motif; other site
717962000612	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
717962000613	65 kDa invariant surface glycoprotein; Provisional; Region: PTZ00208
717962000614	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
717962000615	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717962000616	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717962000617	putative catalytic residues [active]
717962000618	catalytic nucleophile [active]
717962000619	Recombinase; Region: Recombinase; pfam07508
717962000620	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717962000621	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717962000622	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717962000623	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717962000624	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962000625	DNA binding residues [nucleotide binding]
717962000626	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
717962000627	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
717962000628	N-acetyl-D-glucosamine binding site [chemical binding]; other site
717962000629	catalytic residue [active]
717962000630	TIGR02594 family protein; Region: TIGR02594
717962000631	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962000632	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962000633	non-specific DNA binding site [nucleotide binding]; other site
717962000634	salt bridge; other site
717962000635	sequence-specific DNA binding site [nucleotide binding]; other site
717962000636	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
717962000637	Restriction endonuclease; Region: Mrr_cat; pfam04471
717962000638	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
717962000639	Y-family of DNA polymerases; Region: PolY; cl12025
717962000640	active site
717962000641	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497
717962000642	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
717962000643	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
717962000644	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
717962000645	Walker A/P-loop; other site
717962000646	ATP binding site [chemical binding]; other site
717962000647	Q-loop/lid; other site
717962000648	ABC transporter signature motif; other site
717962000649	Walker B; other site
717962000650	D-loop; other site
717962000651	H-loop/switch region; other site
717962000652	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
717962000653	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962000654	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
717962000655	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962000656	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962000657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962000658	active site
717962000659	phosphorylation site [posttranslational modification]
717962000660	intermolecular recognition site; other site
717962000661	dimerization interface [polypeptide binding]; other site
717962000662	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962000663	DNA binding site [nucleotide binding]
717962000664	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962000665	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962000666	dimer interface [polypeptide binding]; other site
717962000667	phosphorylation site [posttranslational modification]
717962000668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962000669	ATP binding site [chemical binding]; other site
717962000670	Mg2+ binding site [ion binding]; other site
717962000671	G-X-G motif; other site
717962000672	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962000673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962000674	non-specific DNA binding site [nucleotide binding]; other site
717962000675	salt bridge; other site
717962000676	sequence-specific DNA binding site [nucleotide binding]; other site
717962000677	MarR family; Region: MarR_2; cl17246
717962000678	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717962000679	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
717962000680	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
717962000681	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962000682	FeS/SAM binding site; other site
717962000683	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
717962000684	conserved cys residue [active]
717962000685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962000686	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962000687	Zn2+ binding site [ion binding]; other site
717962000688	Mg2+ binding site [ion binding]; other site
717962000689	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
717962000690	AAA domain; Region: AAA_14; pfam13173
717962000691	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962000692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962000693	active site
717962000694	phosphorylation site [posttranslational modification]
717962000695	intermolecular recognition site; other site
717962000696	dimerization interface [polypeptide binding]; other site
717962000697	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962000698	DNA binding site [nucleotide binding]
717962000699	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962000700	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962000701	Walker A/P-loop; other site
717962000702	ATP binding site [chemical binding]; other site
717962000703	Q-loop/lid; other site
717962000704	ABC transporter signature motif; other site
717962000705	Walker B; other site
717962000706	D-loop; other site
717962000707	H-loop/switch region; other site
717962000708	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717962000709	dimerization interface [polypeptide binding]; other site
717962000710	putative DNA binding site [nucleotide binding]; other site
717962000711	putative Zn2+ binding site [ion binding]; other site
717962000712	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
717962000713	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717962000714	metal-binding site [ion binding]
717962000715	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717962000716	Soluble P-type ATPase [General function prediction only]; Region: COG4087
717962000717	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
717962000718	L-aspartate oxidase; Provisional; Region: PRK06175
717962000719	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
717962000720	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962000721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962000722	active site
717962000723	phosphorylation site [posttranslational modification]
717962000724	intermolecular recognition site; other site
717962000725	dimerization interface [polypeptide binding]; other site
717962000726	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962000727	DNA binding site [nucleotide binding]
717962000728	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962000729	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962000730	Walker A/P-loop; other site
717962000731	ATP binding site [chemical binding]; other site
717962000732	Q-loop/lid; other site
717962000733	ABC transporter signature motif; other site
717962000734	Walker B; other site
717962000735	D-loop; other site
717962000736	H-loop/switch region; other site
717962000737	FtsX-like permease family; Region: FtsX; pfam02687
717962000738	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717962000739	FtsX-like permease family; Region: FtsX; pfam02687
717962000740	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
717962000741	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
717962000742	Domain of unknown function DUF21; Region: DUF21; pfam01595
717962000743	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
717962000744	Transporter associated domain; Region: CorC_HlyC; smart01091
717962000745	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
717962000746	Domain of unknown function DUF20; Region: UPF0118; pfam01594
717962000747	GH3 auxin-responsive promoter; Region: GH3; pfam03321
717962000748	GH3 auxin-responsive promoter; Region: GH3; pfam03321
717962000749	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
717962000750	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
717962000751	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962000752	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962000753	metal binding site [ion binding]; metal-binding site
717962000754	active site
717962000755	I-site; other site
717962000756	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
717962000757	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962000758	Zn2+ binding site [ion binding]; other site
717962000759	Mg2+ binding site [ion binding]; other site
717962000760	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
717962000761	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
717962000762	active site
717962000763	FMN binding site [chemical binding]; other site
717962000764	substrate binding site [chemical binding]; other site
717962000765	putative catalytic residue [active]
717962000766	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
717962000767	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717962000768	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
717962000769	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
717962000770	SnoaL-like domain; Region: SnoaL_4; pfam13577
717962000771	SnoaL-like domain; Region: SnoaL_4; pfam13577
717962000772	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
717962000773	SnoaL-like domain; Region: SnoaL_4; pfam13577
717962000774	SnoaL-like domain; Region: SnoaL_4; pfam13577
717962000775	SnoaL-like domain; Region: SnoaL_4; pfam13577
717962000776	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
717962000777	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
717962000778	active site
717962000779	catalytic site [active]
717962000780	substrate binding site [chemical binding]; other site
717962000781	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
717962000782	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
717962000783	PLD-like domain; Region: PLDc_2; pfam13091
717962000784	putative homodimer interface [polypeptide binding]; other site
717962000785	putative active site [active]
717962000786	catalytic site [active]
717962000787	DEAD-like helicases superfamily; Region: DEXDc; smart00487
717962000788	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717962000789	ATP binding site [chemical binding]; other site
717962000790	putative Mg++ binding site [ion binding]; other site
717962000791	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717962000792	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
717962000793	nucleotide binding region [chemical binding]; other site
717962000794	ATP-binding site [chemical binding]; other site
717962000795	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
717962000796	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
717962000797	active site
717962000798	8-oxo-dGMP binding site [chemical binding]; other site
717962000799	nudix motif; other site
717962000800	metal binding site [ion binding]; metal-binding site
717962000801	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
717962000802	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
717962000803	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
717962000804	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962000805	non-specific DNA binding site [nucleotide binding]; other site
717962000806	salt bridge; other site
717962000807	sequence-specific DNA binding site [nucleotide binding]; other site
717962000808	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
717962000809	Predicted transcriptional regulator [Transcription]; Region: COG2378
717962000810	WYL domain; Region: WYL; pfam13280
717962000811	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
717962000812	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717962000813	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962000814	catalytic residue [active]
717962000815	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
717962000816	spermidine synthase; Provisional; Region: PRK00811
717962000817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962000818	S-adenosylmethionine binding site [chemical binding]; other site
717962000819	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
717962000820	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
717962000821	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
717962000822	dimer interface [polypeptide binding]; other site
717962000823	active site
717962000824	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717962000825	catalytic residues [active]
717962000826	substrate binding site [chemical binding]; other site
717962000827	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
717962000828	agmatine deiminase; Region: agmatine_aguA; TIGR03380
717962000829	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
717962000830	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
717962000831	putative active site; other site
717962000832	catalytic triad [active]
717962000833	putative dimer interface [polypeptide binding]; other site
717962000834	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
717962000835	Uncharacterized conserved protein [Function unknown]; Region: COG1683
717962000836	DHH family; Region: DHH; pfam01368
717962000837	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
717962000838	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
717962000839	inhibitor-cofactor binding pocket; inhibition site
717962000840	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962000841	catalytic residue [active]
717962000842	peroxiredoxin; Provisional; Region: PRK13189
717962000843	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
717962000844	dimer interface [polypeptide binding]; other site
717962000845	decamer (pentamer of dimers) interface [polypeptide binding]; other site
717962000846	catalytic triad [active]
717962000847	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
717962000848	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717962000849	active site
717962000850	metal binding site [ion binding]; metal-binding site
717962000851	DNA binding site [nucleotide binding]
717962000852	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
717962000853	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
717962000854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962000855	Walker A/P-loop; other site
717962000856	ATP binding site [chemical binding]; other site
717962000857	Q-loop/lid; other site
717962000858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962000859	ABC transporter signature motif; other site
717962000860	Walker B; other site
717962000861	D-loop; other site
717962000862	H-loop/switch region; other site
717962000863	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962000864	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962000865	metal binding site [ion binding]; metal-binding site
717962000866	active site
717962000867	I-site; other site
717962000868	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
717962000869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962000870	active site
717962000871	phosphorylation site [posttranslational modification]
717962000872	intermolecular recognition site; other site
717962000873	dimerization interface [polypeptide binding]; other site
717962000874	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962000875	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
717962000876	putative binding surface; other site
717962000877	active site
717962000878	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
717962000879	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717962000880	NlpC/P60 family; Region: NLPC_P60; cl17555
717962000881	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
717962000882	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
717962000883	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
717962000884	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
717962000885	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
717962000886	GatB domain; Region: GatB_Yqey; smart00845
717962000887	Protein of unknown function, DUF624; Region: DUF624; pfam04854
717962000888	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
717962000889	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
717962000890	ATP binding site [chemical binding]; other site
717962000891	active site
717962000892	substrate binding site [chemical binding]; other site
717962000893	amidophosphoribosyltransferase; Provisional; Region: PRK05793
717962000894	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
717962000895	active site
717962000896	tetramer interface [polypeptide binding]; other site
717962000897	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962000898	active site
717962000899	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
717962000900	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
717962000901	tetramer interface [polypeptide binding]; other site
717962000902	active site
717962000903	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
717962000904	Sulfatase; Region: Sulfatase; cl17466
717962000905	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
717962000906	FGGY family of carbohydrate kinases; Region: FGGY; cd00366
717962000907	N- and C-terminal domain interface [polypeptide binding]; other site
717962000908	active site
717962000909	MgATP binding site [chemical binding]; other site
717962000910	catalytic site [active]
717962000911	metal binding site [ion binding]; metal-binding site
717962000912	carbohydrate binding site [chemical binding]; other site
717962000913	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
717962000914	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
717962000915	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717962000916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962000917	dimer interface [polypeptide binding]; other site
717962000918	conserved gate region; other site
717962000919	putative PBP binding loops; other site
717962000920	ABC-ATPase subunit interface; other site
717962000921	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717962000922	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
717962000923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962000924	dimer interface [polypeptide binding]; other site
717962000925	conserved gate region; other site
717962000926	putative PBP binding loops; other site
717962000927	ABC-ATPase subunit interface; other site
717962000928	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717962000929	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962000930	Walker A/P-loop; other site
717962000931	ATP binding site [chemical binding]; other site
717962000932	Q-loop/lid; other site
717962000933	ABC transporter signature motif; other site
717962000934	Walker B; other site
717962000935	D-loop; other site
717962000936	H-loop/switch region; other site
717962000937	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717962000938	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
717962000939	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962000940	Walker A/P-loop; other site
717962000941	ATP binding site [chemical binding]; other site
717962000942	Q-loop/lid; other site
717962000943	ABC transporter signature motif; other site
717962000944	Walker B; other site
717962000945	D-loop; other site
717962000946	H-loop/switch region; other site
717962000947	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717962000948	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
717962000949	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
717962000950	homodimer interface [polypeptide binding]; other site
717962000951	substrate-cofactor binding pocket; other site
717962000952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962000953	catalytic residue [active]
717962000954	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
717962000955	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
717962000956	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
717962000957	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
717962000958	AP (apurinic/apyrimidinic) site pocket; other site
717962000959	DNA interaction; other site
717962000960	Metal-binding active site; metal-binding site
717962000961	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717962000962	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962000963	heat shock protein 90; Provisional; Region: PRK05218
717962000964	ATP binding site [chemical binding]; other site
717962000965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
717962000966	Mg2+ binding site [ion binding]; other site
717962000967	G-X-G motif; other site
717962000968	AroM protein; Region: AroM; cl17601
717962000969	Protein of unknown function (DUF1177); Region: DUF1177; pfam06675
717962000970	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717962000971	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
717962000972	metal binding site [ion binding]; metal-binding site
717962000973	dimer interface [polypeptide binding]; other site
717962000974	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717962000975	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
717962000976	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
717962000977	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717962000978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962000979	dimer interface [polypeptide binding]; other site
717962000980	conserved gate region; other site
717962000981	putative PBP binding loops; other site
717962000982	ABC-ATPase subunit interface; other site
717962000983	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717962000984	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
717962000985	metal binding site [ion binding]; metal-binding site
717962000986	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717962000987	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962000988	Walker A/P-loop; other site
717962000989	ATP binding site [chemical binding]; other site
717962000990	Q-loop/lid; other site
717962000991	ABC transporter signature motif; other site
717962000992	Walker B; other site
717962000993	D-loop; other site
717962000994	H-loop/switch region; other site
717962000995	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717962000996	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
717962000997	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962000998	Walker A/P-loop; other site
717962000999	ATP binding site [chemical binding]; other site
717962001000	Q-loop/lid; other site
717962001001	ABC transporter signature motif; other site
717962001002	Walker B; other site
717962001003	D-loop; other site
717962001004	H-loop/switch region; other site
717962001005	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717962001006	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
717962001007	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
717962001008	metal binding site [ion binding]; metal-binding site
717962001009	dimer interface [polypeptide binding]; other site
717962001010	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
717962001011	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
717962001012	active site
717962001013	metal binding site [ion binding]; metal-binding site
717962001014	EDD domain protein, DegV family; Region: DegV; TIGR00762
717962001015	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
717962001016	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
717962001017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962001018	dimer interface [polypeptide binding]; other site
717962001019	conserved gate region; other site
717962001020	putative PBP binding loops; other site
717962001021	ABC-ATPase subunit interface; other site
717962001022	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
717962001023	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
717962001024	Walker A/P-loop; other site
717962001025	ATP binding site [chemical binding]; other site
717962001026	Q-loop/lid; other site
717962001027	ABC transporter signature motif; other site
717962001028	Walker B; other site
717962001029	D-loop; other site
717962001030	H-loop/switch region; other site
717962001031	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
717962001032	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
717962001033	Double zinc ribbon; Region: DZR; pfam12773
717962001034	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
717962001035	Double zinc ribbon; Region: DZR; pfam12773
717962001036	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
717962001037	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
717962001038	Part of AAA domain; Region: AAA_19; pfam13245
717962001039	Family description; Region: UvrD_C_2; pfam13538
717962001040	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
717962001041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962001042	S-adenosylmethionine binding site [chemical binding]; other site
717962001043	topology modulation protein; Provisional; Region: PRK07261
717962001044	AAA domain; Region: AAA_17; cl17253
717962001045	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962001046	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962001047	non-specific DNA binding site [nucleotide binding]; other site
717962001048	salt bridge; other site
717962001049	sequence-specific DNA binding site [nucleotide binding]; other site
717962001050	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717962001051	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962001052	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962001053	salt bridge; other site
717962001054	non-specific DNA binding site [nucleotide binding]; other site
717962001055	sequence-specific DNA binding site [nucleotide binding]; other site
717962001056	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962001057	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962001058	non-specific DNA binding site [nucleotide binding]; other site
717962001059	salt bridge; other site
717962001060	sequence-specific DNA binding site [nucleotide binding]; other site
717962001061	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
717962001062	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
717962001063	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
717962001064	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
717962001065	active site 1 [active]
717962001066	active site 2 [active]
717962001067	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
717962001068	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
717962001069	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
717962001070	active site
717962001071	dimer interface [polypeptide binding]; other site
717962001072	motif 1; other site
717962001073	motif 2; other site
717962001074	motif 3; other site
717962001075	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
717962001076	anticodon binding site; other site
717962001077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962001078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962001079	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962001080	dimerization interface [polypeptide binding]; other site
717962001081	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
717962001082	EamA-like transporter family; Region: EamA; pfam00892
717962001083	Propionate catabolism activator; Region: PrpR_N; pfam06506
717962001084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962001085	Walker A motif; other site
717962001086	ATP binding site [chemical binding]; other site
717962001087	Walker B motif; other site
717962001088	arginine finger; other site
717962001089	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962001090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
717962001091	TolA protein; Region: tolA_full; TIGR02794
717962001092	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
717962001093	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
717962001094	putative active site [active]
717962001095	metal binding site [ion binding]; metal-binding site
717962001096	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
717962001097	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
717962001098	inhibitor site; inhibition site
717962001099	active site
717962001100	dimer interface [polypeptide binding]; other site
717962001101	catalytic residue [active]
717962001102	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
717962001103	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
717962001104	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
717962001105	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
717962001106	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
717962001107	BNR repeat-like domain; Region: BNR_2; pfam13088
717962001108	Asp-box motif; other site
717962001109	Domain of unknown function (DUF386); Region: DUF386; cl01047
717962001110	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
717962001111	Divergent AAA domain; Region: AAA_4; pfam04326
717962001112	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
717962001113	MarR family; Region: MarR_2; pfam12802
717962001114	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
717962001115	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
717962001116	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717962001117	metal-binding site [ion binding]
717962001118	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
717962001119	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
717962001120	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
717962001121	Bacterial sugar transferase; Region: Bac_transf; pfam02397
717962001122	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
717962001123	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
717962001124	substrate binding site; other site
717962001125	tetramer interface; other site
717962001126	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
717962001127	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
717962001128	NAD binding site [chemical binding]; other site
717962001129	substrate binding site [chemical binding]; other site
717962001130	homodimer interface [polypeptide binding]; other site
717962001131	active site
717962001132	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
717962001133	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
717962001134	NADP binding site [chemical binding]; other site
717962001135	active site
717962001136	putative substrate binding site [chemical binding]; other site
717962001137	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
717962001138	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
717962001139	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
717962001140	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
717962001141	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
717962001142	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
717962001143	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
717962001144	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
717962001145	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
717962001146	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
717962001147	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717962001148	active site
717962001149	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
717962001150	LicD family; Region: LicD; pfam04991
717962001151	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
717962001152	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
717962001153	CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes [Cell envelope biogenesis, outer membrane]; Region: LicC; COG4750
717962001154	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
717962001155	Phosphotransferase enzyme family; Region: APH; pfam01636
717962001156	active site
717962001157	ATP binding site [chemical binding]; other site
717962001158	substrate binding site [chemical binding]; other site
717962001159	dimer interface [polypeptide binding]; other site
717962001160	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
717962001161	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
717962001162	active site
717962001163	metal-binding site
717962001164	BCCT family transporter; Region: BCCT; pfam02028
717962001165	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
717962001166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962001167	Walker A motif; other site
717962001168	ATP binding site [chemical binding]; other site
717962001169	Walker B motif; other site
717962001170	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
717962001171	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717962001172	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717962001173	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717962001174	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
717962001175	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
717962001176	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001177	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001178	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
717962001179	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
717962001180	Chain length determinant protein; Region: Wzz; cl15801
717962001181	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
717962001182	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962001183	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
717962001184	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
717962001185	NAD(P) binding site [chemical binding]; other site
717962001186	homodimer interface [polypeptide binding]; other site
717962001187	substrate binding site [chemical binding]; other site
717962001188	active site
717962001189	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
717962001190	Bacterial sugar transferase; Region: Bac_transf; pfam02397
717962001191	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
717962001192	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
717962001193	trimer interface [polypeptide binding]; other site
717962001194	active site
717962001195	substrate binding site [chemical binding]; other site
717962001196	CoA binding site [chemical binding]; other site
717962001197	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
717962001198	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
717962001199	Domain of unknown function (DUF1919); Region: DUF1919; cl01628
717962001200	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
717962001201	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
717962001202	active site
717962001203	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
717962001204	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
717962001205	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
717962001206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717962001207	NAD(P) binding site [chemical binding]; other site
717962001208	active site
717962001209	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
717962001210	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
717962001211	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
717962001212	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
717962001213	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717962001214	active site
717962001215	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962001216	Walker A/P-loop; other site
717962001217	ATP binding site [chemical binding]; other site
717962001218	AAA domain; Region: AAA_21; pfam13304
717962001219	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962001220	ABC transporter signature motif; other site
717962001221	Walker B; other site
717962001222	D-loop; other site
717962001223	H-loop/switch region; other site
717962001224	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
717962001225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962001226	Walker A motif; other site
717962001227	ATP binding site [chemical binding]; other site
717962001228	Walker B motif; other site
717962001229	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962001230	active site
717962001231	DNA binding site [nucleotide binding]
717962001232	Int/Topo IB signature motif; other site
717962001233	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
717962001234	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
717962001235	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962001236	active site
717962001237	DNA binding site [nucleotide binding]
717962001238	Int/Topo IB signature motif; other site
717962001239	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
717962001240	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
717962001241	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
717962001242	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
717962001243	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
717962001244	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
717962001245	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
717962001246	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962001247	active site
717962001248	DNA binding site [nucleotide binding]
717962001249	Int/Topo IB signature motif; other site
717962001250	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
717962001251	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962001252	active site
717962001253	DNA binding site [nucleotide binding]
717962001254	Int/Topo IB signature motif; other site
717962001255	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717962001256	Uncharacterized membrane protein [Function unknown]; Region: COG3949
717962001257	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
717962001258	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
717962001259	AAA domain; Region: AAA_14; pfam13173
717962001260	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717962001261	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
717962001262	putative active site [active]
717962001263	putative NTP binding site [chemical binding]; other site
717962001264	putative nucleic acid binding site [nucleotide binding]; other site
717962001265	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
717962001266	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
717962001267	UDP-galactopyranose mutase; Region: GLF; pfam03275
717962001268	Fumarase C-terminus; Region: Fumerase_C; cl00795
717962001269	fumarate hydratase; Provisional; Region: PRK06246
717962001270	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
717962001271	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
717962001272	Cl- selectivity filter; other site
717962001273	Cl- binding residues [ion binding]; other site
717962001274	pore gating glutamate residue; other site
717962001275	dimer interface [polypeptide binding]; other site
717962001276	DNA gyrase subunit A; Validated; Region: PRK05560
717962001277	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
717962001278	CAP-like domain; other site
717962001279	active site
717962001280	primary dimer interface [polypeptide binding]; other site
717962001281	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717962001282	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717962001283	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717962001284	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717962001285	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717962001286	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
717962001287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962001288	Mg2+ binding site [ion binding]; other site
717962001289	G-X-G motif; other site
717962001290	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
717962001291	anchoring element; other site
717962001292	dimer interface [polypeptide binding]; other site
717962001293	ATP binding site [chemical binding]; other site
717962001294	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
717962001295	active site
717962001296	putative metal-binding site [ion binding]; other site
717962001297	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
717962001298	recombination protein F; Reviewed; Region: recF; PRK00064
717962001299	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
717962001300	Walker A/P-loop; other site
717962001301	ATP binding site [chemical binding]; other site
717962001302	Q-loop/lid; other site
717962001303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962001304	ABC transporter signature motif; other site
717962001305	Walker B; other site
717962001306	D-loop; other site
717962001307	H-loop/switch region; other site
717962001308	S4 domain; Region: S4_2; pfam13275
717962001309	DNA polymerase III subunit beta; Validated; Region: PRK05643
717962001310	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
717962001311	putative DNA binding surface [nucleotide binding]; other site
717962001312	dimer interface [polypeptide binding]; other site
717962001313	beta-clamp/clamp loader binding surface; other site
717962001314	beta-clamp/translesion DNA polymerase binding surface; other site
717962001315	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
717962001316	ribonuclease P; Reviewed; Region: rnpA; PRK00499
717962001317	Haemolytic domain; Region: Haemolytic; pfam01809
717962001318	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
717962001319	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
717962001320	G-X-X-G motif; other site
717962001321	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
717962001322	RxxxH motif; other site
717962001323	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
717962001324	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
717962001325	trmE is a tRNA modification GTPase; Region: trmE; cd04164
717962001326	G1 box; other site
717962001327	GTP/Mg2+ binding site [chemical binding]; other site
717962001328	Switch I region; other site
717962001329	G2 box; other site
717962001330	Switch II region; other site
717962001331	G3 box; other site
717962001332	G4 box; other site
717962001333	G5 box; other site
717962001334	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
717962001335	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
717962001336	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
717962001337	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
717962001338	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962001339	Coenzyme A binding pocket [chemical binding]; other site
717962001340	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
717962001341	ParB-like nuclease domain; Region: ParB; smart00470
717962001342	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
717962001343	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
717962001344	P-loop; other site
717962001345	Magnesium ion binding site [ion binding]; other site
717962001346	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
717962001347	Magnesium ion binding site [ion binding]; other site
717962001348	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
717962001349	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
717962001350	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
717962001351	active site
717962001352	HIGH motif; other site
717962001353	KMSK motif region; other site
717962001354	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
717962001355	tRNA binding surface [nucleotide binding]; other site
717962001356	anticodon binding site; other site
717962001357	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
717962001358	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717962001359	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962001360	catalytic residue [active]
717962001361	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
717962001362	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
717962001363	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
717962001364	active site
717962001365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962001366	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
717962001367	Walker A motif; other site
717962001368	ATP binding site [chemical binding]; other site
717962001369	Walker B motif; other site
717962001370	arginine finger; other site
717962001371	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
717962001372	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
717962001373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962001374	S-adenosylmethionine binding site [chemical binding]; other site
717962001375	Predicted methyltransferases [General function prediction only]; Region: COG0313
717962001376	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
717962001377	putative SAM binding site [chemical binding]; other site
717962001378	putative homodimer interface [polypeptide binding]; other site
717962001379	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
717962001380	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
717962001381	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
717962001382	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
717962001383	Isochorismatase family; Region: Isochorismatase; pfam00857
717962001384	catalytic triad [active]
717962001385	dimer interface [polypeptide binding]; other site
717962001386	conserved cis-peptide bond; other site
717962001387	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
717962001388	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
717962001389	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717962001390	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
717962001391	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
717962001392	active site
717962001393	metal-binding site [ion binding]
717962001394	active site
717962001395	nucleotide-binding site [chemical binding]; other site
717962001396	nucleotide-binding site [chemical binding]; other site
717962001397	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
717962001398	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
717962001399	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
717962001400	active site
717962001401	HIGH motif; other site
717962001402	KMSKS motif; other site
717962001403	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
717962001404	tRNA binding surface [nucleotide binding]; other site
717962001405	anticodon binding site; other site
717962001406	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
717962001407	dimer interface [polypeptide binding]; other site
717962001408	putative tRNA-binding site [nucleotide binding]; other site
717962001409	Predicted membrane protein [Function unknown]; Region: COG2860
717962001410	UPF0126 domain; Region: UPF0126; pfam03458
717962001411	UPF0126 domain; Region: UPF0126; pfam03458
717962001412	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
717962001413	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
717962001414	active site
717962001415	Transposase; Region: HTH_Tnp_1; cl17663
717962001416	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
717962001417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962001418	S-adenosylmethionine binding site [chemical binding]; other site
717962001419	L-aspartate oxidase; Provisional; Region: PRK06175
717962001420	FAD binding domain; Region: FAD_binding_2; pfam00890
717962001421	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
717962001422	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
717962001423	dimerization interface [polypeptide binding]; other site
717962001424	active site
717962001425	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
717962001426	HTH domain; Region: HTH_11; pfam08279
717962001427	3H domain; Region: 3H; pfam02829
717962001428	Quinolinate synthetase A protein; Region: NadA; pfam02445
717962001429	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
717962001430	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
717962001431	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
717962001432	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
717962001433	dimer interface [polypeptide binding]; other site
717962001434	putative functional site; other site
717962001435	putative MPT binding site; other site
717962001436	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
717962001437	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
717962001438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962001439	Walker A motif; other site
717962001440	ATP binding site [chemical binding]; other site
717962001441	Walker B motif; other site
717962001442	arginine finger; other site
717962001443	Peptidase family M41; Region: Peptidase_M41; pfam01434
717962001444	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962001445	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962001446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962001447	Walker A/P-loop; other site
717962001448	ATP binding site [chemical binding]; other site
717962001449	Q-loop/lid; other site
717962001450	ABC transporter signature motif; other site
717962001451	Walker B; other site
717962001452	D-loop; other site
717962001453	H-loop/switch region; other site
717962001454	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962001455	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962001456	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
717962001457	Walker A/P-loop; other site
717962001458	ATP binding site [chemical binding]; other site
717962001459	Q-loop/lid; other site
717962001460	ABC transporter signature motif; other site
717962001461	Walker B; other site
717962001462	D-loop; other site
717962001463	H-loop/switch region; other site
717962001464	Transcriptional regulator [Transcription]; Region: LytR; COG1316
717962001465	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
717962001466	active site
717962001467	catalytic site [active]
717962001468	substrate binding site [chemical binding]; other site
717962001469	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962001470	active site
717962001471	DNA binding site [nucleotide binding]
717962001472	Int/Topo IB signature motif; other site
717962001473	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717962001474	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
717962001475	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
717962001476	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
717962001477	CoenzymeA binding site [chemical binding]; other site
717962001478	subunit interaction site [polypeptide binding]; other site
717962001479	PHB binding site; other site
717962001480	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
717962001481	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
717962001482	PYR/PP interface [polypeptide binding]; other site
717962001483	dimer interface [polypeptide binding]; other site
717962001484	TPP binding site [chemical binding]; other site
717962001485	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
717962001486	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
717962001487	TPP-binding site [chemical binding]; other site
717962001488	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
717962001489	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
717962001490	putative valine binding site [chemical binding]; other site
717962001491	dimer interface [polypeptide binding]; other site
717962001492	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
717962001493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962001494	S-adenosylmethionine binding site [chemical binding]; other site
717962001495	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
717962001496	Bacterial SH3 domain; Region: SH3_3; cl17532
717962001497	Bacterial SH3 domain; Region: SH3_3; cl17532
717962001498	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
717962001499	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
717962001500	Holin family; Region: Phage_holin_4; pfam05105
717962001501	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
717962001502	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
717962001503	active site
717962001504	metal binding site [ion binding]; metal-binding site
717962001505	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
717962001506	cell division protein MraZ; Reviewed; Region: PRK00326
717962001507	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717962001508	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
717962001509	Phosphopantetheine attachment site; Region: PP-binding; cl09936
717962001510	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
717962001511	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
717962001512	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962001513	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
717962001514	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
717962001515	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
717962001516	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
717962001517	Repair protein; Region: Repair_PSII; pfam04536
717962001518	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
717962001519	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962001520	Coenzyme A binding pocket [chemical binding]; other site
717962001521	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962001522	non-specific DNA binding site [nucleotide binding]; other site
717962001523	salt bridge; other site
717962001524	sequence-specific DNA binding site [nucleotide binding]; other site
717962001525	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
717962001526	AAA domain; Region: AAA_14; pfam13173
717962001527	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
717962001528	phosphate binding site [ion binding]; other site
717962001529	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
717962001530	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
717962001531	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
717962001532	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
717962001533	active site
717962001534	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
717962001535	nucleoside/Zn binding site; other site
717962001536	dimer interface [polypeptide binding]; other site
717962001537	catalytic motif [active]
717962001538	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
717962001539	MgtC family; Region: MgtC; pfam02308
717962001540	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717962001541	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
717962001542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962001543	dimer interface [polypeptide binding]; other site
717962001544	conserved gate region; other site
717962001545	ABC-ATPase subunit interface; other site
717962001546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962001547	dimer interface [polypeptide binding]; other site
717962001548	conserved gate region; other site
717962001549	putative PBP binding loops; other site
717962001550	ABC-ATPase subunit interface; other site
717962001551	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
717962001552	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962001553	Walker A/P-loop; other site
717962001554	ATP binding site [chemical binding]; other site
717962001555	Q-loop/lid; other site
717962001556	ABC transporter signature motif; other site
717962001557	Walker B; other site
717962001558	D-loop; other site
717962001559	H-loop/switch region; other site
717962001560	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
717962001561	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
717962001562	active site
717962001563	catalytic site [active]
717962001564	metal binding site [ion binding]; metal-binding site
717962001565	dimer interface [polypeptide binding]; other site
717962001566	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
717962001567	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
717962001568	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
717962001569	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
717962001570	putative hexamer interface [polypeptide binding]; other site
717962001571	putative hexagonal pore; other site
717962001572	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
717962001573	putative hexamer interface [polypeptide binding]; other site
717962001574	putative hexagonal pore; other site
717962001575	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
717962001576	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
717962001577	Hexamer interface [polypeptide binding]; other site
717962001578	Putative hexagonal pore residue; other site
717962001579	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
717962001580	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
717962001581	Propanediol utilisation protein PduL; Region: PduL; pfam06130
717962001582	Propanediol utilisation protein PduL; Region: PduL; pfam06130
717962001583	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
717962001584	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
717962001585	Hexamer/Pentamer interface [polypeptide binding]; other site
717962001586	central pore; other site
717962001587	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
717962001588	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
717962001589	putative hexamer interface [polypeptide binding]; other site
717962001590	putative hexagonal pore; other site
717962001591	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
717962001592	putative hexamer interface [polypeptide binding]; other site
717962001593	putative hexagonal pore; other site
717962001594	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
717962001595	putative hexamer interface [polypeptide binding]; other site
717962001596	putative hexagonal pore; other site
717962001597	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
717962001598	G1 box; other site
717962001599	GTP/Mg2+ binding site [chemical binding]; other site
717962001600	Switch I region; other site
717962001601	G3 box; other site
717962001602	Switch II region; other site
717962001603	G4 box; other site
717962001604	G5 box; other site
717962001605	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962001606	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962001607	non-specific DNA binding site [nucleotide binding]; other site
717962001608	salt bridge; other site
717962001609	sequence-specific DNA binding site [nucleotide binding]; other site
717962001610	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962001611	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962001612	non-specific DNA binding site [nucleotide binding]; other site
717962001613	salt bridge; other site
717962001614	sequence-specific DNA binding site [nucleotide binding]; other site
717962001615	Accessory gene regulator B; Region: AgrB; pfam04647
717962001616	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
717962001617	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
717962001618	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
717962001619	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
717962001620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962001621	active site
717962001622	phosphorylation site [posttranslational modification]
717962001623	intermolecular recognition site; other site
717962001624	dimerization interface [polypeptide binding]; other site
717962001625	LytTr DNA-binding domain; Region: LytTR; smart00850
717962001626	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
717962001627	hypothetical protein; Validated; Region: PRK08116
717962001628	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962001629	Walker A motif; other site
717962001630	ATP binding site [chemical binding]; other site
717962001631	Walker B motif; other site
717962001632	arginine finger; other site
717962001633	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717962001634	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962001635	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
717962001636	Walker A/P-loop; other site
717962001637	ATP binding site [chemical binding]; other site
717962001638	Q-loop/lid; other site
717962001639	ABC transporter signature motif; other site
717962001640	Walker B; other site
717962001641	D-loop; other site
717962001642	H-loop/switch region; other site
717962001643	Cytochrome C biogenesis protein; Region: CcmH; cl01179
717962001644	carbamate kinase; Reviewed; Region: PRK12686
717962001645	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
717962001646	putative substrate binding site [chemical binding]; other site
717962001647	nucleotide binding site [chemical binding]; other site
717962001648	nucleotide binding site [chemical binding]; other site
717962001649	homodimer interface [polypeptide binding]; other site
717962001650	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
717962001651	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
717962001652	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
717962001653	peptidase; Reviewed; Region: PRK13004
717962001654	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
717962001655	putative metal binding site [ion binding]; other site
717962001656	putative dimer interface [polypeptide binding]; other site
717962001657	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
717962001658	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
717962001659	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962001660	catalytic residue [active]
717962001661	xanthine permease; Region: pbuX; TIGR03173
717962001662	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
717962001663	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962001664	active site
717962001665	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
717962001666	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
717962001667	active site clefts [active]
717962001668	zinc binding site [ion binding]; other site
717962001669	dimer interface [polypeptide binding]; other site
717962001670	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962001671	Zn2+ binding site [ion binding]; other site
717962001672	Mg2+ binding site [ion binding]; other site
717962001673	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717962001674	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
717962001675	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717962001676	nucleotide binding site [chemical binding]; other site
717962001677	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
717962001678	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
717962001679	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962001680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
717962001681	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717962001682	MarR family; Region: MarR_2; pfam12802
717962001683	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
717962001684	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717962001685	active site
717962001686	catalytic tetrad [active]
717962001687	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717962001688	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
717962001689	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717962001690	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962001691	catalytic residue [active]
717962001692	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717962001693	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962001694	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
717962001695	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962001696	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717962001697	putative DNA binding site [nucleotide binding]; other site
717962001698	putative Zn2+ binding site [ion binding]; other site
717962001699	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
717962001700	putative dimerization interface [polypeptide binding]; other site
717962001701	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
717962001702	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717962001703	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717962001704	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
717962001705	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717962001706	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717962001707	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
717962001708	IMP binding site; other site
717962001709	dimer interface [polypeptide binding]; other site
717962001710	interdomain contacts; other site
717962001711	partial ornithine binding site; other site
717962001712	Heavy-metal-associated domain; Region: HMA; pfam00403
717962001713	metal-binding site [ion binding]
717962001714	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
717962001715	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
717962001716	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
717962001717	active site turn [active]
717962001718	phosphorylation site [posttranslational modification]
717962001719	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
717962001720	HPr interaction site; other site
717962001721	glycerol kinase (GK) interaction site [polypeptide binding]; other site
717962001722	active site
717962001723	phosphorylation site [posttranslational modification]
717962001724	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
717962001725	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
717962001726	Chloramphenicol acetyltransferase; Region: CAT; cl02008
717962001727	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
717962001728	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
717962001729	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
717962001730	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
717962001731	PhoU domain; Region: PhoU; pfam01895
717962001732	PhoU domain; Region: PhoU; pfam01895
717962001733	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962001734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962001735	active site
717962001736	phosphorylation site [posttranslational modification]
717962001737	intermolecular recognition site; other site
717962001738	dimerization interface [polypeptide binding]; other site
717962001739	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962001740	DNA binding site [nucleotide binding]
717962001741	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962001742	dimer interface [polypeptide binding]; other site
717962001743	phosphorylation site [posttranslational modification]
717962001744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962001745	ATP binding site [chemical binding]; other site
717962001746	Mg2+ binding site [ion binding]; other site
717962001747	G-X-G motif; other site
717962001748	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717962001749	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717962001750	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
717962001751	Putative esterase; Region: Esterase; pfam00756
717962001752	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
717962001753	Membrane transport protein; Region: Mem_trans; pfam03547
717962001754	intracellular protease, PfpI family; Region: PfpI; TIGR01382
717962001755	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
717962001756	conserved cys residue [active]
717962001757	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
717962001758	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
717962001759	H+ Antiporter protein; Region: 2A0121; TIGR00900
717962001760	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717962001761	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717962001762	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
717962001763	nucleoside/Zn binding site; other site
717962001764	dimer interface [polypeptide binding]; other site
717962001765	catalytic motif [active]
717962001766	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
717962001767	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
717962001768	active site
717962001769	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
717962001770	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962001771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962001772	homodimer interface [polypeptide binding]; other site
717962001773	catalytic residue [active]
717962001774	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
717962001775	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
717962001776	active site
717962001777	dimerization interface [polypeptide binding]; other site
717962001778	EDD domain protein, DegV family; Region: DegV; TIGR00762
717962001779	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
717962001780	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
717962001781	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
717962001782	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
717962001783	putative active site [active]
717962001784	putative metal binding site [ion binding]; other site
717962001785	AAA domain; Region: AAA_14; pfam13173
717962001786	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
717962001787	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
717962001788	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
717962001789	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
717962001790	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
717962001791	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
717962001792	4Fe-4S binding domain; Region: Fer4_6; pfam12837
717962001793	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
717962001794	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
717962001795	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
717962001796	putative [4Fe-4S] binding site [ion binding]; other site
717962001797	putative molybdopterin cofactor binding site [chemical binding]; other site
717962001798	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
717962001799	molybdopterin cofactor binding site; other site
717962001800	Coat F domain; Region: Coat_F; pfam07875
717962001801	Predicted permeases [General function prediction only]; Region: COG0679
717962001802	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
717962001803	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
717962001804	active site
717962001805	metal binding site [ion binding]; metal-binding site
717962001806	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717962001807	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
717962001808	active site
717962001809	catalytic tetrad [active]
717962001810	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
717962001811	Domain of unknown function DUF20; Region: UPF0118; pfam01594
717962001812	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962001813	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
717962001814	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
717962001815	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962001816	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
717962001817	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717962001818	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
717962001819	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
717962001820	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
717962001821	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
717962001822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962001823	Walker A/P-loop; other site
717962001824	ATP binding site [chemical binding]; other site
717962001825	Q-loop/lid; other site
717962001826	ABC transporter signature motif; other site
717962001827	Walker B; other site
717962001828	D-loop; other site
717962001829	H-loop/switch region; other site
717962001830	TOBE domain; Region: TOBE_2; pfam08402
717962001831	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
717962001832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962001833	dimer interface [polypeptide binding]; other site
717962001834	conserved gate region; other site
717962001835	putative PBP binding loops; other site
717962001836	ABC-ATPase subunit interface; other site
717962001837	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
717962001838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962001839	dimer interface [polypeptide binding]; other site
717962001840	conserved gate region; other site
717962001841	putative PBP binding loops; other site
717962001842	ABC-ATPase subunit interface; other site
717962001843	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
717962001844	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717962001845	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
717962001846	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
717962001847	putative active site [active]
717962001848	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
717962001849	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
717962001850	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
717962001851	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
717962001852	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
717962001853	substrate binding site [chemical binding]; other site
717962001854	ATP binding site [chemical binding]; other site
717962001855	Protein of unknown function DUF45; Region: DUF45; pfam01863
717962001856	EamA-like transporter family; Region: EamA; pfam00892
717962001857	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
717962001858	EamA-like transporter family; Region: EamA; pfam00892
717962001859	aspartate kinase; Reviewed; Region: PRK09034
717962001860	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
717962001861	nucleotide binding site [chemical binding]; other site
717962001862	substrate binding site [chemical binding]; other site
717962001863	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
717962001864	allosteric regulatory residue; other site
717962001865	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
717962001866	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
717962001867	AIR carboxylase; Region: AIRC; smart01001
717962001868	Protein of unknown function DUF111; Region: DUF111; cl03398
717962001869	Protein of unknown function DUF111; Region: DUF111; pfam01969
717962001870	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
717962001871	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
717962001872	Ligand Binding Site [chemical binding]; other site
717962001873	ParB-like nuclease domain; Region: ParBc; pfam02195
717962001874	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
717962001875	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
717962001876	Walker A/P-loop; other site
717962001877	ATP binding site [chemical binding]; other site
717962001878	Q-loop/lid; other site
717962001879	ABC transporter signature motif; other site
717962001880	Walker B; other site
717962001881	D-loop; other site
717962001882	H-loop/switch region; other site
717962001883	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
717962001884	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
717962001885	Ligand binding site; other site
717962001886	Putative Catalytic site; other site
717962001887	DXD motif; other site
717962001888	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
717962001889	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
717962001890	catalytic motif [active]
717962001891	Zn binding site [ion binding]; other site
717962001892	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
717962001893	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
717962001894	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
717962001895	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
717962001896	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
717962001897	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
717962001898	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
717962001899	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
717962001900	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
717962001901	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
717962001902	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
717962001903	beta subunit interaction interface [polypeptide binding]; other site
717962001904	Walker A motif; other site
717962001905	ATP binding site [chemical binding]; other site
717962001906	Walker B motif; other site
717962001907	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
717962001908	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
717962001909	core domain interface [polypeptide binding]; other site
717962001910	delta subunit interface [polypeptide binding]; other site
717962001911	epsilon subunit interface [polypeptide binding]; other site
717962001912	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
717962001913	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
717962001914	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
717962001915	alpha subunit interaction interface [polypeptide binding]; other site
717962001916	Walker A motif; other site
717962001917	ATP binding site [chemical binding]; other site
717962001918	Walker B motif; other site
717962001919	inhibitor binding site; inhibition site
717962001920	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
717962001921	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
717962001922	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
717962001923	gamma subunit interface [polypeptide binding]; other site
717962001924	epsilon subunit interface [polypeptide binding]; other site
717962001925	LBP interface [polypeptide binding]; other site
717962001926	conserved hypothetical integral membrane protein; Region: TIGR03766
717962001927	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
717962001928	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
717962001929	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
717962001930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717962001931	NAD(P) binding site [chemical binding]; other site
717962001932	active site
717962001933	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001934	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717962001935	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
717962001936	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
717962001937	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001938	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001939	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001940	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001941	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
717962001942	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717962001943	NlpC/P60 family; Region: NLPC_P60; cl17555
717962001944	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
717962001945	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
717962001946	Ligand binding site; other site
717962001947	Putative Catalytic site; other site
717962001948	DXD motif; other site
717962001949	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
717962001950	putative sugar binding sites [chemical binding]; other site
717962001951	Q-X-W motif; other site
717962001952	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
717962001953	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
717962001954	putative sugar binding sites [chemical binding]; other site
717962001955	Q-X-W motif; other site
717962001956	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717962001957	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717962001958	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962001959	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
717962001960	Cation efflux family; Region: Cation_efflux; pfam01545
717962001961	PBP superfamily domain; Region: PBP_like_2; cl17296
717962001962	PBP superfamily domain; Region: PBP_like_2; cl17296
717962001963	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
717962001964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962001965	dimer interface [polypeptide binding]; other site
717962001966	conserved gate region; other site
717962001967	putative PBP binding loops; other site
717962001968	ABC-ATPase subunit interface; other site
717962001969	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
717962001970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962001971	dimer interface [polypeptide binding]; other site
717962001972	conserved gate region; other site
717962001973	putative PBP binding loops; other site
717962001974	ABC-ATPase subunit interface; other site
717962001975	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
717962001976	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
717962001977	Walker A/P-loop; other site
717962001978	ATP binding site [chemical binding]; other site
717962001979	Q-loop/lid; other site
717962001980	ABC transporter signature motif; other site
717962001981	Walker B; other site
717962001982	D-loop; other site
717962001983	H-loop/switch region; other site
717962001984	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
717962001985	PhoU domain; Region: PhoU; pfam01895
717962001986	PhoU domain; Region: PhoU; pfam01895
717962001987	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
717962001988	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
717962001989	active site
717962001990	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
717962001991	Ricin-type beta-trefoil; Region: RICIN; smart00458
717962001992	putative sugar binding sites [chemical binding]; other site
717962001993	Q-X-W motif; other site
717962001994	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
717962001995	putative sugar binding sites [chemical binding]; other site
717962001996	Q-X-W motif; other site
717962001997	Ricin-type beta-trefoil; Region: RICIN; smart00458
717962001998	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
717962001999	hydroxyglutarate oxidase; Provisional; Region: PRK11728
717962002000	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
717962002001	AzlC protein; Region: AzlC; cl00570
717962002002	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
717962002003	active site residue [active]
717962002004	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
717962002005	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
717962002006	Ligand Binding Site [chemical binding]; other site
717962002007	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
717962002008	active site
717962002009	catalytic triad [active]
717962002010	oxyanion hole [active]
717962002011	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
717962002012	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
717962002013	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717962002014	substrate binding site [chemical binding]; other site
717962002015	oxyanion hole (OAH) forming residues; other site
717962002016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962002017	dimer interface [polypeptide binding]; other site
717962002018	conserved gate region; other site
717962002019	ABC-ATPase subunit interface; other site
717962002020	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
717962002021	FAD binding domain; Region: FAD_binding_4; pfam01565
717962002022	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
717962002023	hypothetical protein; Provisional; Region: PRK08912
717962002024	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962002025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962002026	homodimer interface [polypeptide binding]; other site
717962002027	catalytic residue [active]
717962002028	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002029	non-specific DNA binding site [nucleotide binding]; other site
717962002030	salt bridge; other site
717962002031	sequence-specific DNA binding site [nucleotide binding]; other site
717962002032	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717962002033	putative efflux protein, MATE family; Region: matE; TIGR00797
717962002034	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
717962002035	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
717962002036	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
717962002037	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962002038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962002039	Walker A motif; other site
717962002040	ATP binding site [chemical binding]; other site
717962002041	Walker B motif; other site
717962002042	arginine finger; other site
717962002043	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962002044	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
717962002045	Citrate transporter; Region: CitMHS; pfam03600
717962002046	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
717962002047	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
717962002048	putative homodimer interface [polypeptide binding]; other site
717962002049	putative homotetramer interface [polypeptide binding]; other site
717962002050	putative allosteric switch controlling residues; other site
717962002051	putative metal binding site [ion binding]; other site
717962002052	putative homodimer-homodimer interface [polypeptide binding]; other site
717962002053	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962002054	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962002055	Walker A/P-loop; other site
717962002056	ATP binding site [chemical binding]; other site
717962002057	Q-loop/lid; other site
717962002058	ABC transporter signature motif; other site
717962002059	Walker B; other site
717962002060	D-loop; other site
717962002061	H-loop/switch region; other site
717962002062	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717962002063	FtsX-like permease family; Region: FtsX; pfam02687
717962002064	FtsX-like permease family; Region: FtsX; pfam02687
717962002065	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
717962002066	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
717962002067	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
717962002068	ligand binding site [chemical binding]; other site
717962002069	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
717962002070	hybrid cluster protein; Provisional; Region: PRK05290
717962002071	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717962002072	ACS interaction site; other site
717962002073	CODH interaction site; other site
717962002074	metal cluster binding site [ion binding]; other site
717962002075	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717962002076	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
717962002077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962002078	dimer interface [polypeptide binding]; other site
717962002079	conserved gate region; other site
717962002080	putative PBP binding loops; other site
717962002081	ABC-ATPase subunit interface; other site
717962002082	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
717962002083	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
717962002084	Major Facilitator Superfamily; Region: MFS_1; pfam07690
717962002085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717962002086	putative substrate translocation pore; other site
717962002087	Response regulator receiver domain; Region: Response_reg; pfam00072
717962002088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962002089	active site
717962002090	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
717962002091	phosphorylation site [posttranslational modification]
717962002092	intermolecular recognition site; other site
717962002093	dimerization interface [polypeptide binding]; other site
717962002094	Histidine kinase; Region: His_kinase; pfam06580
717962002095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962002096	ATP binding site [chemical binding]; other site
717962002097	Mg2+ binding site [ion binding]; other site
717962002098	G-X-G motif; other site
717962002099	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
717962002100	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962002101	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
717962002102	active site
717962002103	Major Facilitator Superfamily; Region: MFS_1; pfam07690
717962002104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717962002105	putative substrate translocation pore; other site
717962002106	MarR family; Region: MarR_2; pfam12802
717962002107	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
717962002108	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962002109	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717962002110	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
717962002111	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
717962002112	DNA binding residues [nucleotide binding]
717962002113	dimer interface [polypeptide binding]; other site
717962002114	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
717962002115	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
717962002116	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962002117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962002118	homodimer interface [polypeptide binding]; other site
717962002119	catalytic residue [active]
717962002120	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
717962002121	Rubredoxin; Region: Rubredoxin; pfam00301
717962002122	iron binding site [ion binding]; other site
717962002123	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
717962002124	Rubrerythrin [Energy production and conversion]; Region: COG1592
717962002125	diiron binding motif [ion binding]; other site
717962002126	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962002127	Uncharacterized conserved protein [Function unknown]; Region: COG1284
717962002128	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962002129	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
717962002130	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
717962002131	putative FMN binding site [chemical binding]; other site
717962002132	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962002133	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002134	non-specific DNA binding site [nucleotide binding]; other site
717962002135	salt bridge; other site
717962002136	sequence-specific DNA binding site [nucleotide binding]; other site
717962002137	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962002138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962002139	active site
717962002140	phosphorylation site [posttranslational modification]
717962002141	intermolecular recognition site; other site
717962002142	dimerization interface [polypeptide binding]; other site
717962002143	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962002144	DNA binding site [nucleotide binding]
717962002145	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962002146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962002147	dimer interface [polypeptide binding]; other site
717962002148	phosphorylation site [posttranslational modification]
717962002149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962002150	ATP binding site [chemical binding]; other site
717962002151	Mg2+ binding site [ion binding]; other site
717962002152	G-X-G motif; other site
717962002153	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962002154	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962002155	Walker A/P-loop; other site
717962002156	ATP binding site [chemical binding]; other site
717962002157	Q-loop/lid; other site
717962002158	ABC transporter signature motif; other site
717962002159	Walker B; other site
717962002160	D-loop; other site
717962002161	H-loop/switch region; other site
717962002162	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717962002163	FtsX-like permease family; Region: FtsX; pfam02687
717962002164	FtsX-like permease family; Region: FtsX; pfam02687
717962002165	Helix-turn-helix domain; Region: HTH_17; pfam12728
717962002166	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
717962002167	MobA/MobL family; Region: MobA_MobL; pfam03389
717962002168	Fic/DOC family; Region: Fic; pfam02661
717962002169	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
717962002170	homodimer interface [polypeptide binding]; other site
717962002171	chemical substrate binding site [chemical binding]; other site
717962002172	oligomer interface [polypeptide binding]; other site
717962002173	metal binding site [ion binding]; metal-binding site
717962002174	Formaldehyde dehydrogenases; Region: FDH_like; cd05278
717962002175	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
717962002176	catalytic Zn binding site [ion binding]; other site
717962002177	NAD(P) binding site [chemical binding]; other site
717962002178	structural Zn binding site [ion binding]; other site
717962002179	isoaspartyl dipeptidase; Provisional; Region: PRK10657
717962002180	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962002181	active site
717962002182	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962002183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962002184	Walker A/P-loop; other site
717962002185	ATP binding site [chemical binding]; other site
717962002186	Q-loop/lid; other site
717962002187	ABC transporter signature motif; other site
717962002188	Walker B; other site
717962002189	D-loop; other site
717962002190	H-loop/switch region; other site
717962002191	ABC-2 type transporter; Region: ABC2_membrane; cl17235
717962002192	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
717962002193	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717962002194	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717962002195	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962002196	Coenzyme A binding pocket [chemical binding]; other site
717962002197	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
717962002198	YoaP-like; Region: YoaP; pfam14268
717962002199	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
717962002200	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
717962002201	putative metal binding site [ion binding]; other site
717962002202	TfoX N-terminal domain; Region: TfoX_N; pfam04993
717962002203	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
717962002204	Divergent AAA domain; Region: AAA_4; pfam04326
717962002205	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
717962002206	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002207	non-specific DNA binding site [nucleotide binding]; other site
717962002208	salt bridge; other site
717962002209	sequence-specific DNA binding site [nucleotide binding]; other site
717962002210	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
717962002211	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
717962002212	cofactor binding site; other site
717962002213	DNA binding site [nucleotide binding]
717962002214	substrate interaction site [chemical binding]; other site
717962002215	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
717962002216	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
717962002217	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
717962002218	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
717962002219	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
717962002220	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
717962002221	Predicted transcriptional regulator [Transcription]; Region: COG3355
717962002222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962002223	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
717962002224	Walker A motif; other site
717962002225	ATP binding site [chemical binding]; other site
717962002226	Walker B motif; other site
717962002227	arginine finger; other site
717962002228	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
717962002229	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
717962002230	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962002231	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
717962002232	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
717962002233	Int/Topo IB signature motif; other site
717962002234	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002235	non-specific DNA binding site [nucleotide binding]; other site
717962002236	salt bridge; other site
717962002237	sequence-specific DNA binding site [nucleotide binding]; other site
717962002238	Domain of unknown function (DUF955); Region: DUF955; pfam06114
717962002239	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962002240	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962002241	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962002242	dimerization interface [polypeptide binding]; other site
717962002243	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717962002244	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962002245	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002246	non-specific DNA binding site [nucleotide binding]; other site
717962002247	salt bridge; other site
717962002248	sequence-specific DNA binding site [nucleotide binding]; other site
717962002249	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
717962002250	putative protofilament interface [polypeptide binding]; other site
717962002251	nucleotide binding site [chemical binding]; other site
717962002252	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
717962002253	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
717962002254	putative active site pocket [active]
717962002255	dimerization interface [polypeptide binding]; other site
717962002256	putative catalytic residue [active]
717962002257	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002258	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002259	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002260	S-adenosylmethionine synthetase; Validated; Region: PRK05250
717962002261	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
717962002262	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
717962002263	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
717962002264	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
717962002265	Toprim-like; Region: Toprim_2; pfam13155
717962002266	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
717962002267	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
717962002268	DNA methylase; Region: N6_N4_Mtase; pfam01555
717962002269	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717962002270	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
717962002271	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
717962002272	PrgI family protein; Region: PrgI; pfam12666
717962002273	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
717962002274	N-acetyl-D-glucosamine binding site [chemical binding]; other site
717962002275	catalytic residue [active]
717962002276	TIGR02594 family protein; Region: TIGR02594
717962002277	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
717962002278	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
717962002279	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
717962002280	active site
717962002281	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
717962002282	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
717962002283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962002284	active site
717962002285	phosphorylation site [posttranslational modification]
717962002286	intermolecular recognition site; other site
717962002287	dimerization interface [polypeptide binding]; other site
717962002288	LytTr DNA-binding domain; Region: LytTR; pfam04397
717962002289	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
717962002290	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
717962002291	RHS Repeat; Region: RHS_repeat; pfam05593
717962002292	RHS Repeat; Region: RHS_repeat; pfam05593
717962002293	RHS Repeat; Region: RHS_repeat; cl11982
717962002294	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
717962002295	RHS Repeat; Region: RHS_repeat; pfam05593
717962002296	RHS Repeat; Region: RHS_repeat; pfam05593
717962002297	RHS Repeat; Region: RHS_repeat; pfam05593
717962002298	RHS Repeat; Region: RHS_repeat; pfam05593
717962002299	RHS Repeat; Region: RHS_repeat; pfam05593
717962002300	RHS Repeat; Region: RHS_repeat; pfam05593
717962002301	RHS Repeat; Region: RHS_repeat; pfam05593
717962002302	RHS Repeat; Region: RHS_repeat; pfam05593
717962002303	RHS Repeat; Region: RHS_repeat; pfam05593
717962002304	RHS Repeat; Region: RHS_repeat; pfam05593
717962002305	RHS Repeat; Region: RHS_repeat; pfam05593
717962002306	RHS Repeat; Region: RHS_repeat; pfam05593
717962002307	RHS Repeat; Region: RHS_repeat; pfam05593
717962002308	RHS Repeat; Region: RHS_repeat; pfam05593
717962002309	RHS Repeat; Region: RHS_repeat; pfam05593
717962002310	RHS Repeat; Region: RHS_repeat; pfam05593
717962002311	RHS Repeat; Region: RHS_repeat; pfam05593
717962002312	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
717962002313	RHS Repeat; Region: RHS_repeat; pfam05593
717962002314	RHS Repeat; Region: RHS_repeat; pfam05593
717962002315	RHS Repeat; Region: RHS_repeat; pfam05593
717962002316	RHS Repeat; Region: RHS_repeat; pfam05593
717962002317	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
717962002318	RHS Repeat; Region: RHS_repeat; pfam05593
717962002319	RHS Repeat; Region: RHS_repeat; pfam05593
717962002320	RHS Repeat; Region: RHS_repeat; cl11982
717962002321	RHS Repeat; Region: RHS_repeat; pfam05593
717962002322	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
717962002323	RHS Repeat; Region: RHS_repeat; pfam05593
717962002324	RHS Repeat; Region: RHS_repeat; pfam05593
717962002325	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
717962002326	Protein of unknown function (DUF419); Region: DUF419; pfam04237
717962002327	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
717962002328	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717962002329	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
717962002330	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
717962002331	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
717962002332	intersubunit interface [polypeptide binding]; other site
717962002333	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
717962002334	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
717962002335	ABC-ATPase subunit  interface; other site
717962002336	dimer interface [polypeptide binding]; other site
717962002337	putative PBP binding regions; other site
717962002338	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
717962002339	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
717962002340	Walker A/P-loop; other site
717962002341	ATP binding site [chemical binding]; other site
717962002342	Q-loop/lid; other site
717962002343	ABC transporter signature motif; other site
717962002344	Walker B; other site
717962002345	D-loop; other site
717962002346	H-loop/switch region; other site
717962002347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
717962002348	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
717962002349	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
717962002350	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962002351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962002352	Walker A/P-loop; other site
717962002353	ATP binding site [chemical binding]; other site
717962002354	Q-loop/lid; other site
717962002355	ABC transporter signature motif; other site
717962002356	Walker B; other site
717962002357	D-loop; other site
717962002358	H-loop/switch region; other site
717962002359	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962002360	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962002361	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962002362	Walker A/P-loop; other site
717962002363	ATP binding site [chemical binding]; other site
717962002364	Q-loop/lid; other site
717962002365	ABC transporter signature motif; other site
717962002366	Walker B; other site
717962002367	D-loop; other site
717962002368	H-loop/switch region; other site
717962002369	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
717962002370	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
717962002371	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717962002372	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962002373	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962002374	DNA binding site [nucleotide binding]
717962002375	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
717962002376	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
717962002377	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962002378	active site
717962002379	DNA binding site [nucleotide binding]
717962002380	Int/Topo IB signature motif; other site
717962002381	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
717962002382	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962002383	active site
717962002384	DNA binding site [nucleotide binding]
717962002385	Int/Topo IB signature motif; other site
717962002386	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
717962002387	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
717962002388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002389	non-specific DNA binding site [nucleotide binding]; other site
717962002390	salt bridge; other site
717962002391	sequence-specific DNA binding site [nucleotide binding]; other site
717962002392	Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174
717962002393	PLD-like domain; Region: PLDc_2; pfam13091
717962002394	putative active site [active]
717962002395	catalytic site [active]
717962002396	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
717962002397	putative protofilament interface [polypeptide binding]; other site
717962002398	nucleotide binding site [chemical binding]; other site
717962002399	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002400	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002401	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002402	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002403	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002404	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002405	Cna protein B-type domain; Region: Cna_B; pfam05738
717962002406	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
717962002407	active site
717962002408	catalytic site [active]
717962002409	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
717962002410	Toprim-like; Region: Toprim_2; pfam13155
717962002411	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
717962002412	DNA methylase; Region: N6_N4_Mtase; pfam01555
717962002413	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717962002414	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
717962002415	phosphoribosylanthranilate isomerase; Region: PLN02363
717962002416	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
717962002417	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717962002418	Walker A motif; other site
717962002419	ATP binding site [chemical binding]; other site
717962002420	Walker B motif; other site
717962002421	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
717962002422	PrgI family protein; Region: PrgI; pfam12666
717962002423	AAA-like domain; Region: AAA_10; pfam12846
717962002424	Domain of unknown function DUF87; Region: DUF87; pfam01935
717962002425	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
717962002426	N-acetyl-D-glucosamine binding site [chemical binding]; other site
717962002427	catalytic residue [active]
717962002428	CHAP domain; Region: CHAP; cl17642
717962002429	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002430	non-specific DNA binding site [nucleotide binding]; other site
717962002431	salt bridge; other site
717962002432	sequence-specific DNA binding site [nucleotide binding]; other site
717962002433	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717962002434	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962002435	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
717962002436	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
717962002437	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962002438	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962002439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962002440	Walker A/P-loop; other site
717962002441	ATP binding site [chemical binding]; other site
717962002442	Q-loop/lid; other site
717962002443	ABC transporter signature motif; other site
717962002444	Walker B; other site
717962002445	D-loop; other site
717962002446	H-loop/switch region; other site
717962002447	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962002448	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962002449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962002450	Walker A/P-loop; other site
717962002451	ATP binding site [chemical binding]; other site
717962002452	Q-loop/lid; other site
717962002453	ABC transporter signature motif; other site
717962002454	Walker B; other site
717962002455	D-loop; other site
717962002456	H-loop/switch region; other site
717962002457	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
717962002458	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
717962002459	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
717962002460	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
717962002461	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
717962002462	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962002463	active site
717962002464	DNA binding site [nucleotide binding]
717962002465	Int/Topo IB signature motif; other site
717962002466	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
717962002467	active site
717962002468	catalytic residues [active]
717962002469	DNA binding site [nucleotide binding]
717962002470	Int/Topo IB signature motif; other site
717962002471	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962002472	active site
717962002473	DNA binding site [nucleotide binding]
717962002474	Int/Topo IB signature motif; other site
717962002475	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
717962002476	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
717962002477	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
717962002478	Cupin domain; Region: Cupin_2; cl17218
717962002479	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
717962002480	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
717962002481	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
717962002482	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
717962002483	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
717962002484	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
717962002485	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
717962002486	catalytic triad [active]
717962002487	Protein of unknown function (DUF328); Region: DUF328; pfam03883
717962002488	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
717962002489	Rubredoxin; Region: Rubredoxin; pfam00301
717962002490	iron binding site [ion binding]; other site
717962002491	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
717962002492	catalytic residues [active]
717962002493	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
717962002494	homodimer interface [polypeptide binding]; other site
717962002495	chemical substrate binding site [chemical binding]; other site
717962002496	oligomer interface [polypeptide binding]; other site
717962002497	metal binding site [ion binding]; metal-binding site
717962002498	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
717962002499	GIY-YIG motif/motif A; other site
717962002500	putative active site [active]
717962002501	putative metal binding site [ion binding]; other site
717962002502	Part of AAA domain; Region: AAA_19; pfam13245
717962002503	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
717962002504	Uncharacterized conserved protein [Function unknown]; Region: COG3410
717962002505	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
717962002506	Low molecular weight phosphatase family; Region: LMWPc; cd00115
717962002507	active site
717962002508	Predicted dehydrogenase [General function prediction only]; Region: COG0579
717962002509	hydroxyglutarate oxidase; Provisional; Region: PRK11728
717962002510	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
717962002511	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
717962002512	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717962002513	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
717962002514	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
717962002515	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717962002516	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962002517	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962002518	DNA binding residues [nucleotide binding]
717962002519	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
717962002520	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
717962002521	catalytic core [active]
717962002522	Predicted membrane protein [Function unknown]; Region: COG2246
717962002523	GtrA-like protein; Region: GtrA; pfam04138
717962002524	Predicted membrane protein [Function unknown]; Region: COG1511
717962002525	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
717962002526	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
717962002527	Predicted membrane protein [Function unknown]; Region: COG1511
717962002528	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
717962002529	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
717962002530	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
717962002531	active site
717962002532	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717962002533	TPR motif; other site
717962002534	Tetratricopeptide repeat; Region: TPR_16; pfam13432
717962002535	binding surface
717962002536	NAD-dependent deacetylase; Provisional; Region: PRK00481
717962002537	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
717962002538	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
717962002539	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
717962002540	N- and C-terminal domain interface [polypeptide binding]; other site
717962002541	putative active site [active]
717962002542	MgATP binding site [chemical binding]; other site
717962002543	catalytic site [active]
717962002544	metal binding site [ion binding]; metal-binding site
717962002545	putative xylulose binding site [chemical binding]; other site
717962002546	putative homodimer interface [polypeptide binding]; other site
717962002547	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
717962002548	active site
717962002549	catalytic site [active]
717962002550	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
717962002551	propionate/acetate kinase; Provisional; Region: PRK12379
717962002552	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002553	non-specific DNA binding site [nucleotide binding]; other site
717962002554	salt bridge; other site
717962002555	sequence-specific DNA binding site [nucleotide binding]; other site
717962002556	Predicted transcriptional regulators [Transcription]; Region: COG1733
717962002557	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
717962002558	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
717962002559	FMN binding site [chemical binding]; other site
717962002560	dimer interface [polypeptide binding]; other site
717962002561	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
717962002562	Stage II sporulation protein; Region: SpoIID; pfam08486
717962002563	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
717962002564	Peptidase family M23; Region: Peptidase_M23; pfam01551
717962002565	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
717962002566	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
717962002567	active site
717962002568	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
717962002569	active site
717962002570	N-terminal domain interface [polypeptide binding]; other site
717962002571	heme uptake protein IsdC; Region: IsdC; TIGR03656
717962002572	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
717962002573	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
717962002574	intersubunit interface [polypeptide binding]; other site
717962002575	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
717962002576	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
717962002577	ABC-ATPase subunit  interface; other site
717962002578	dimer interface [polypeptide binding]; other site
717962002579	putative PBP binding regions; other site
717962002580	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
717962002581	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
717962002582	Walker A/P-loop; other site
717962002583	ATP binding site [chemical binding]; other site
717962002584	Q-loop/lid; other site
717962002585	ABC transporter signature motif; other site
717962002586	Walker B; other site
717962002587	D-loop; other site
717962002588	H-loop/switch region; other site
717962002589	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
717962002590	GIY-YIG motif/motif A; other site
717962002591	putative active site [active]
717962002592	putative metal binding site [ion binding]; other site
717962002593	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
717962002594	dimer interface [polypeptide binding]; other site
717962002595	Citrate synthase; Region: Citrate_synt; pfam00285
717962002596	active site
717962002597	citrylCoA binding site [chemical binding]; other site
717962002598	oxalacetate/citrate binding site [chemical binding]; other site
717962002599	coenzyme A binding site [chemical binding]; other site
717962002600	catalytic triad [active]
717962002601	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
717962002602	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
717962002603	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
717962002604	putative active site [active]
717962002605	catalytic site [active]
717962002606	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
717962002607	putative active site [active]
717962002608	catalytic site [active]
717962002609	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962002610	Radical SAM superfamily; Region: Radical_SAM; pfam04055
717962002611	FeS/SAM binding site; other site
717962002612	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
717962002613	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
717962002614	dimer interface [polypeptide binding]; other site
717962002615	substrate binding site [chemical binding]; other site
717962002616	ATP binding site [chemical binding]; other site
717962002617	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
717962002618	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962002619	PAS domain; Region: PAS_9; pfam13426
717962002620	putative active site [active]
717962002621	heme pocket [chemical binding]; other site
717962002622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962002623	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962002624	Walker A motif; other site
717962002625	ATP binding site [chemical binding]; other site
717962002626	Walker B motif; other site
717962002627	arginine finger; other site
717962002628	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
717962002629	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
717962002630	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
717962002631	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
717962002632	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717962002633	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717962002634	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
717962002635	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
717962002636	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
717962002637	active site
717962002638	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
717962002639	DRTGG domain; Region: DRTGG; pfam07085
717962002640	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
717962002641	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
717962002642	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
717962002643	Putative Fe-S cluster; Region: FeS; cl17515
717962002644	DRTGG domain; Region: DRTGG; pfam07085
717962002645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962002646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962002647	ATP binding site [chemical binding]; other site
717962002648	Mg2+ binding site [ion binding]; other site
717962002649	G-X-G motif; other site
717962002650	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
717962002651	dimer interface [polypeptide binding]; other site
717962002652	[2Fe-2S] cluster binding site [ion binding]; other site
717962002653	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
717962002654	dimer interface [polypeptide binding]; other site
717962002655	[2Fe-2S] cluster binding site [ion binding]; other site
717962002656	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
717962002657	SLBB domain; Region: SLBB; pfam10531
717962002658	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
717962002659	4Fe-4S binding domain; Region: Fer4; pfam00037
717962002660	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
717962002661	4Fe-4S binding domain; Region: Fer4; pfam00037
717962002662	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
717962002663	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
717962002664	catalytic loop [active]
717962002665	iron binding site [ion binding]; other site
717962002666	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
717962002667	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
717962002668	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
717962002669	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
717962002670	Predicted membrane protein [Function unknown]; Region: COG2364
717962002671	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717962002672	MarR family; Region: MarR_2; pfam12802
717962002673	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
717962002674	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
717962002675	YcxB-like protein; Region: YcxB; pfam14317
717962002676	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
717962002677	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
717962002678	Putative Fe-S cluster; Region: FeS; cl17515
717962002679	PAS domain S-box; Region: sensory_box; TIGR00229
717962002680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962002681	putative active site [active]
717962002682	heme pocket [chemical binding]; other site
717962002683	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
717962002684	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
717962002685	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
717962002686	Predicted amidohydrolase [General function prediction only]; Region: COG0388
717962002687	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
717962002688	putative active site [active]
717962002689	catalytic triad [active]
717962002690	dimer interface [polypeptide binding]; other site
717962002691	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
717962002692	IHF dimer interface [polypeptide binding]; other site
717962002693	IHF - DNA interface [nucleotide binding]; other site
717962002694	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717962002695	RNA binding surface [nucleotide binding]; other site
717962002696	YabP family; Region: YabP; cl06766
717962002697	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
717962002698	Septum formation initiator; Region: DivIC; pfam04977
717962002699	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
717962002700	stage II sporulation protein E; Region: spore_II_E; TIGR02865
717962002701	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
717962002702	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
717962002703	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
717962002704	TilS substrate C-terminal domain; Region: TilS_C; smart00977
717962002705	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
717962002706	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962002707	active site
717962002708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
717962002709	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
717962002710	Probable transposase; Region: OrfB_IS605; pfam01385
717962002711	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
717962002712	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
717962002713	homodimer interface [polypeptide binding]; other site
717962002714	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
717962002715	active site
717962002716	homodimer interface [polypeptide binding]; other site
717962002717	catalytic site [active]
717962002718	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
717962002719	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962002720	FeS/SAM binding site; other site
717962002721	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
717962002722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962002723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962002724	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962002725	dimerization interface [polypeptide binding]; other site
717962002726	AzlC protein; Region: AzlC; pfam03591
717962002727	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
717962002728	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
717962002729	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
717962002730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962002731	S-adenosylmethionine binding site [chemical binding]; other site
717962002732	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717962002733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962002734	dimer interface [polypeptide binding]; other site
717962002735	conserved gate region; other site
717962002736	putative PBP binding loops; other site
717962002737	ABC-ATPase subunit interface; other site
717962002738	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
717962002739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962002740	dimer interface [polypeptide binding]; other site
717962002741	conserved gate region; other site
717962002742	putative PBP binding loops; other site
717962002743	ABC-ATPase subunit interface; other site
717962002744	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717962002745	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
717962002746	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
717962002747	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962002748	Walker A/P-loop; other site
717962002749	ATP binding site [chemical binding]; other site
717962002750	Q-loop/lid; other site
717962002751	ABC transporter signature motif; other site
717962002752	Walker B; other site
717962002753	D-loop; other site
717962002754	H-loop/switch region; other site
717962002755	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
717962002756	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
717962002757	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962002758	Walker A/P-loop; other site
717962002759	ATP binding site [chemical binding]; other site
717962002760	Q-loop/lid; other site
717962002761	ABC transporter signature motif; other site
717962002762	Walker B; other site
717962002763	D-loop; other site
717962002764	H-loop/switch region; other site
717962002765	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
717962002766	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
717962002767	SWIM zinc finger; Region: SWIM; pfam04434
717962002768	Predicted membrane protein [Function unknown]; Region: COG1971
717962002769	Domain of unknown function DUF; Region: DUF204; pfam02659
717962002770	Domain of unknown function DUF; Region: DUF204; pfam02659
717962002771	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962002772	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962002773	substrate binding pocket [chemical binding]; other site
717962002774	membrane-bound complex binding site; other site
717962002775	hinge residues; other site
717962002776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962002777	dimer interface [polypeptide binding]; other site
717962002778	conserved gate region; other site
717962002779	putative PBP binding loops; other site
717962002780	ABC-ATPase subunit interface; other site
717962002781	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
717962002782	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
717962002783	Walker A/P-loop; other site
717962002784	ATP binding site [chemical binding]; other site
717962002785	Q-loop/lid; other site
717962002786	ABC transporter signature motif; other site
717962002787	Walker B; other site
717962002788	D-loop; other site
717962002789	H-loop/switch region; other site
717962002790	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
717962002791	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
717962002792	active site
717962002793	catalytic triad [active]
717962002794	oxyanion hole [active]
717962002795	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
717962002796	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
717962002797	putative ligand binding site [chemical binding]; other site
717962002798	putative NAD binding site [chemical binding]; other site
717962002799	catalytic site [active]
717962002800	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
717962002801	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
717962002802	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
717962002803	Mg++ binding site [ion binding]; other site
717962002804	putative catalytic motif [active]
717962002805	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
717962002806	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
717962002807	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
717962002808	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
717962002809	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
717962002810	putative L-serine binding site [chemical binding]; other site
717962002811	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
717962002812	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
717962002813	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
717962002814	HTH domain; Region: HTH_11; pfam08279
717962002815	3H domain; Region: 3H; pfam02829
717962002816	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
717962002817	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
717962002818	oligomer interface [polypeptide binding]; other site
717962002819	putative active site [active]
717962002820	metal binding site [ion binding]; metal-binding site
717962002821	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
717962002822	Predicted membrane protein [Function unknown]; Region: COG2323
717962002823	putative hydratase; Provisional; Region: PRK11413
717962002824	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
717962002825	substrate binding site [chemical binding]; other site
717962002826	ligand binding site [chemical binding]; other site
717962002827	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
717962002828	substrate binding site [chemical binding]; other site
717962002829	isocitrate dehydrogenase; Validated; Region: PRK08299
717962002830	threonine dehydratase; Provisional; Region: PRK08198
717962002831	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
717962002832	tetramer interface [polypeptide binding]; other site
717962002833	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962002834	catalytic residue [active]
717962002835	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
717962002836	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
717962002837	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
717962002838	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
717962002839	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
717962002840	active site
717962002841	catalytic site [active]
717962002842	substrate binding site [chemical binding]; other site
717962002843	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717962002844	VanW like protein; Region: VanW; pfam04294
717962002845	G5 domain; Region: G5; pfam07501
717962002846	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
717962002847	ATP binding site [chemical binding]; other site
717962002848	dimerization interface [polypeptide binding]; other site
717962002849	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
717962002850	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
717962002851	AsnC family; Region: AsnC_trans_reg; pfam01037
717962002852	hypothetical protein; Validated; Region: PRK07682
717962002853	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962002854	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962002855	homodimer interface [polypeptide binding]; other site
717962002856	catalytic residue [active]
717962002857	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
717962002858	uracil transporter; Provisional; Region: PRK10720
717962002859	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962002860	active site
717962002861	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
717962002862	MutS domain III; Region: MutS_III; pfam05192
717962002863	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
717962002864	Walker A/P-loop; other site
717962002865	ATP binding site [chemical binding]; other site
717962002866	Q-loop/lid; other site
717962002867	ABC transporter signature motif; other site
717962002868	Walker B; other site
717962002869	D-loop; other site
717962002870	H-loop/switch region; other site
717962002871	Smr domain; Region: Smr; pfam01713
717962002872	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
717962002873	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
717962002874	generic binding surface I; other site
717962002875	generic binding surface II; other site
717962002876	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962002877	Zn2+ binding site [ion binding]; other site
717962002878	Mg2+ binding site [ion binding]; other site
717962002879	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
717962002880	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
717962002881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962002882	S-adenosylmethionine binding site [chemical binding]; other site
717962002883	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962002884	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
717962002885	Walker A/P-loop; other site
717962002886	ATP binding site [chemical binding]; other site
717962002887	Q-loop/lid; other site
717962002888	ABC transporter signature motif; other site
717962002889	Walker B; other site
717962002890	D-loop; other site
717962002891	H-loop/switch region; other site
717962002892	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962002893	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962002894	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962002895	DNA binding site [nucleotide binding]
717962002896	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962002897	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002898	non-specific DNA binding site [nucleotide binding]; other site
717962002899	salt bridge; other site
717962002900	sequence-specific DNA binding site [nucleotide binding]; other site
717962002901	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
717962002902	Electron transfer flavoprotein domain; Region: ETF; smart00893
717962002903	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
717962002904	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
717962002905	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
717962002906	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
717962002907	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717962002908	zinc binding site [ion binding]; other site
717962002909	putative ligand binding site [chemical binding]; other site
717962002910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962002911	non-specific DNA binding site [nucleotide binding]; other site
717962002912	salt bridge; other site
717962002913	sequence-specific DNA binding site [nucleotide binding]; other site
717962002914	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717962002915	Na2 binding site [ion binding]; other site
717962002916	putative substrate binding site 1 [chemical binding]; other site
717962002917	Na binding site 1 [ion binding]; other site
717962002918	putative substrate binding site 2 [chemical binding]; other site
717962002919	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
717962002920	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
717962002921	active site
717962002922	nucleophile elbow; other site
717962002923	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
717962002924	Coenzyme A transferase; Region: CoA_trans; smart00882
717962002925	Coenzyme A transferase; Region: CoA_trans; cl17247
717962002926	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
717962002927	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
717962002928	active site
717962002929	metal binding site [ion binding]; metal-binding site
717962002930	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962002931	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
717962002932	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
717962002933	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962002934	L-lactate permease; Region: Lactate_perm; cl00701
717962002935	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
717962002936	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
717962002937	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962002938	active site
717962002939	motif I; other site
717962002940	motif II; other site
717962002941	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962002942	motif II; other site
717962002943	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
717962002944	Protein kinase domain; Region: Pkinase; pfam00069
717962002945	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
717962002946	active site
717962002947	ATP binding site [chemical binding]; other site
717962002948	substrate binding site [chemical binding]; other site
717962002949	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
717962002950	active site
717962002951	substrate binding site [chemical binding]; other site
717962002952	activation loop (A-loop); other site
717962002953	activation loop (A-loop); other site
717962002954	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
717962002955	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
717962002956	active site
717962002957	putative homodimer interface [polypeptide binding]; other site
717962002958	SAM binding site [chemical binding]; other site
717962002959	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
717962002960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962002961	S-adenosylmethionine binding site [chemical binding]; other site
717962002962	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
717962002963	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962002964	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
717962002965	catalytic triad [active]
717962002966	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
717962002967	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
717962002968	putative dimer interface [polypeptide binding]; other site
717962002969	active site pocket [active]
717962002970	putative cataytic base [active]
717962002971	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
717962002972	cobalamin synthase; Reviewed; Region: cobS; PRK00235
717962002973	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
717962002974	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
717962002975	catalytic core [active]
717962002976	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
717962002977	cobyric acid synthase; Provisional; Region: PRK00784
717962002978	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962002979	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962002980	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
717962002981	catalytic triad [active]
717962002982	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
717962002983	Precorrin-8X methylmutase; Region: CbiC; pfam02570
717962002984	DNA polymerase IV; Reviewed; Region: PRK03103
717962002985	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
717962002986	active site
717962002987	DNA binding site [nucleotide binding]
717962002988	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
717962002989	shikimate kinase; Reviewed; Region: aroK; PRK00131
717962002990	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
717962002991	ADP binding site [chemical binding]; other site
717962002992	magnesium binding site [ion binding]; other site
717962002993	putative shikimate binding site; other site
717962002994	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
717962002995	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
717962002996	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
717962002997	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
717962002998	hinge; other site
717962002999	active site
717962003000	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962003001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962003002	active site
717962003003	phosphorylation site [posttranslational modification]
717962003004	intermolecular recognition site; other site
717962003005	dimerization interface [polypeptide binding]; other site
717962003006	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962003007	DNA binding site [nucleotide binding]
717962003008	Putative zinc-finger; Region: zf-HC2; pfam13490
717962003009	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717962003010	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717962003011	glycogen branching enzyme; Provisional; Region: PRK12313
717962003012	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
717962003013	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
717962003014	active site
717962003015	catalytic site [active]
717962003016	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
717962003017	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
717962003018	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
717962003019	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
717962003020	ATP binding site [chemical binding]; other site
717962003021	Walker A motif; other site
717962003022	hexamer interface [polypeptide binding]; other site
717962003023	Walker B motif; other site
717962003024	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717962003025	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
717962003026	catalytic residues [active]
717962003027	catalytic nucleophile [active]
717962003028	Recombinase; Region: Recombinase; pfam07508
717962003029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962003030	non-specific DNA binding site [nucleotide binding]; other site
717962003031	salt bridge; other site
717962003032	sequence-specific DNA binding site [nucleotide binding]; other site
717962003033	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
717962003034	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
717962003035	Methyltransferase domain; Region: Methyltransf_26; pfam13659
717962003036	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717962003037	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962003038	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962003039	non-specific DNA binding site [nucleotide binding]; other site
717962003040	salt bridge; other site
717962003041	sequence-specific DNA binding site [nucleotide binding]; other site
717962003042	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
717962003043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962003044	sequence-specific DNA binding site [nucleotide binding]; other site
717962003045	salt bridge; other site
717962003046	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962003047	active site
717962003048	DNA binding site [nucleotide binding]
717962003049	Int/Topo IB signature motif; other site
717962003050	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717962003051	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717962003052	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
717962003053	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
717962003054	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
717962003055	TadE-like protein; Region: TadE; pfam07811
717962003056	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
717962003057	phosphopeptide binding site; other site
717962003058	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
717962003059	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
717962003060	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
717962003061	active site
717962003062	catalytic site [active]
717962003063	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
717962003064	active site
717962003065	catalytic site [active]
717962003066	Rhomboid family; Region: Rhomboid; pfam01694
717962003067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962003068	ATP binding site [chemical binding]; other site
717962003069	Mg2+ binding site [ion binding]; other site
717962003070	G-X-G motif; other site
717962003071	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
717962003072	HIT family signature motif; other site
717962003073	catalytic residue [active]
717962003074	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
717962003075	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
717962003076	active site
717962003077	homodimer interface [polypeptide binding]; other site
717962003078	TSCPD domain; Region: TSCPD; cl14834
717962003079	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
717962003080	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
717962003081	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
717962003082	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
717962003083	active site
717962003084	dimer interface [polypeptide binding]; other site
717962003085	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
717962003086	dimer interface [polypeptide binding]; other site
717962003087	active site
717962003088	phenylhydantoinase; Validated; Region: PRK08323
717962003089	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
717962003090	tetramer interface [polypeptide binding]; other site
717962003091	active site
717962003092	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
717962003093	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
717962003094	DRTGG domain; Region: DRTGG; pfam07085
717962003095	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
717962003096	DHHA2 domain; Region: DHHA2; pfam02833
717962003097	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
717962003098	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
717962003099	DRTGG domain; Region: DRTGG; pfam07085
717962003100	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
717962003101	DHH family; Region: DHH; pfam01368
717962003102	DHHA2 domain; Region: DHHA2; pfam02833
717962003103	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
717962003104	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
717962003105	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
717962003106	active site
717962003107	SAM binding site [chemical binding]; other site
717962003108	homodimer interface [polypeptide binding]; other site
717962003109	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
717962003110	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
717962003111	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
717962003112	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
717962003113	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
717962003114	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962003115	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717962003116	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962003117	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
717962003118	active site
717962003119	motif I; other site
717962003120	motif II; other site
717962003121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962003122	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
717962003123	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
717962003124	active site
717962003125	substrate binding site [chemical binding]; other site
717962003126	metal binding site [ion binding]; metal-binding site
717962003127	PrcB C-terminal; Region: PrcB_C; pfam14343
717962003128	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
717962003129	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
717962003130	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
717962003131	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
717962003132	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717962003133	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
717962003134	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
717962003135	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
717962003136	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962003137	DNA-binding site [nucleotide binding]; DNA binding site
717962003138	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
717962003139	FCD domain; Region: FCD; pfam07729
717962003140	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
717962003141	Spore germination protein; Region: Spore_permease; cl17796
717962003142	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
717962003143	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
717962003144	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717962003145	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
717962003146	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
717962003147	intersubunit interface [polypeptide binding]; other site
717962003148	active site
717962003149	zinc binding site [ion binding]; other site
717962003150	Na+ binding site [ion binding]; other site
717962003151	endonuclease IV; Provisional; Region: PRK01060
717962003152	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
717962003153	AP (apurinic/apyrimidinic) site pocket; other site
717962003154	DNA interaction; other site
717962003155	Metal-binding active site; metal-binding site
717962003156	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
717962003157	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
717962003158	active site
717962003159	NTP binding site [chemical binding]; other site
717962003160	metal binding triad [ion binding]; metal-binding site
717962003161	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
717962003162	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
717962003163	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
717962003164	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
717962003165	putative acyl-acceptor binding pocket; other site
717962003166	4-alpha-glucanotransferase; Provisional; Region: PRK14508
717962003167	Methyltransferase domain; Region: Methyltransf_31; pfam13847
717962003168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962003169	S-adenosylmethionine binding site [chemical binding]; other site
717962003170	6-phosphofructokinase; Provisional; Region: PRK03202
717962003171	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
717962003172	active site
717962003173	ADP/pyrophosphate binding site [chemical binding]; other site
717962003174	dimerization interface [polypeptide binding]; other site
717962003175	allosteric effector site; other site
717962003176	fructose-1,6-bisphosphate binding site; other site
717962003177	recombination factor protein RarA; Reviewed; Region: PRK13342
717962003178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962003179	Walker A motif; other site
717962003180	ATP binding site [chemical binding]; other site
717962003181	Walker B motif; other site
717962003182	arginine finger; other site
717962003183	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
717962003184	Uncharacterized conserved protein [Function unknown]; Region: COG3379
717962003185	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
717962003186	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
717962003187	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
717962003188	intersubunit interface [polypeptide binding]; other site
717962003189	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
717962003190	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
717962003191	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
717962003192	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
717962003193	ABC-ATPase subunit  interface; other site
717962003194	dimer interface [polypeptide binding]; other site
717962003195	putative PBP binding regions; other site
717962003196	Double zinc ribbon; Region: DZR; pfam12773
717962003197	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
717962003198	rod shape-determining protein Mbl; Provisional; Region: PRK13928
717962003199	MreB and similar proteins; Region: MreB_like; cd10225
717962003200	nucleotide binding site [chemical binding]; other site
717962003201	Mg binding site [ion binding]; other site
717962003202	putative protofilament interaction site [polypeptide binding]; other site
717962003203	RodZ interaction site [polypeptide binding]; other site
717962003204	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
717962003205	AAA domain; Region: AAA_30; pfam13604
717962003206	Family description; Region: UvrD_C_2; pfam13538
717962003207	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
717962003208	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
717962003209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962003210	Walker A motif; other site
717962003211	ATP binding site [chemical binding]; other site
717962003212	Walker B motif; other site
717962003213	arginine finger; other site
717962003214	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962003215	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
717962003216	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962003217	active site
717962003218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962003219	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962003220	Walker A motif; other site
717962003221	ATP binding site [chemical binding]; other site
717962003222	Walker B motif; other site
717962003223	arginine finger; other site
717962003224	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
717962003225	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
717962003226	putative homodimer interface [polypeptide binding]; other site
717962003227	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
717962003228	heterodimer interface [polypeptide binding]; other site
717962003229	homodimer interface [polypeptide binding]; other site
717962003230	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
717962003231	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
717962003232	23S rRNA interface [nucleotide binding]; other site
717962003233	L7/L12 interface [polypeptide binding]; other site
717962003234	putative thiostrepton binding site; other site
717962003235	L25 interface [polypeptide binding]; other site
717962003236	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
717962003237	mRNA/rRNA interface [nucleotide binding]; other site
717962003238	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
717962003239	23S rRNA interface [nucleotide binding]; other site
717962003240	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
717962003241	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
717962003242	core dimer interface [polypeptide binding]; other site
717962003243	peripheral dimer interface [polypeptide binding]; other site
717962003244	L10 interface [polypeptide binding]; other site
717962003245	L11 interface [polypeptide binding]; other site
717962003246	putative EF-Tu interaction site [polypeptide binding]; other site
717962003247	putative EF-G interaction site [polypeptide binding]; other site
717962003248	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
717962003249	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
717962003250	active site
717962003251	metal binding site [ion binding]; metal-binding site
717962003252	YARHG domain; Region: YARHG; pfam13308
717962003253	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
717962003254	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
717962003255	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
717962003256	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
717962003257	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
717962003258	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
717962003259	RPB1 interaction site [polypeptide binding]; other site
717962003260	RPB10 interaction site [polypeptide binding]; other site
717962003261	RPB11 interaction site [polypeptide binding]; other site
717962003262	RPB3 interaction site [polypeptide binding]; other site
717962003263	RPB12 interaction site [polypeptide binding]; other site
717962003264	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
717962003265	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
717962003266	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
717962003267	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
717962003268	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
717962003269	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
717962003270	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
717962003271	G-loop; other site
717962003272	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
717962003273	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
717962003274	DNA binding site [nucleotide binding]
717962003275	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
717962003276	Uncharacterized conserved protein [Function unknown]; Region: COG1284
717962003277	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962003278	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962003279	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
717962003280	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
717962003281	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
717962003282	putative ligand binding site [chemical binding]; other site
717962003283	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962003284	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
717962003285	TM-ABC transporter signature motif; other site
717962003286	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
717962003287	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
717962003288	Walker A/P-loop; other site
717962003289	ATP binding site [chemical binding]; other site
717962003290	Q-loop/lid; other site
717962003291	ABC transporter signature motif; other site
717962003292	Walker B; other site
717962003293	D-loop; other site
717962003294	H-loop/switch region; other site
717962003295	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
717962003296	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
717962003297	Walker A/P-loop; other site
717962003298	ATP binding site [chemical binding]; other site
717962003299	Q-loop/lid; other site
717962003300	ABC transporter signature motif; other site
717962003301	Walker B; other site
717962003302	D-loop; other site
717962003303	H-loop/switch region; other site
717962003304	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717962003305	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
717962003306	PA/protease or protease-like domain interface [polypeptide binding]; other site
717962003307	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
717962003308	Peptidase family M28; Region: Peptidase_M28; pfam04389
717962003309	metal binding site [ion binding]; metal-binding site
717962003310	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
717962003311	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962003312	Coenzyme A binding pocket [chemical binding]; other site
717962003313	glycerol kinase; Provisional; Region: glpK; PRK00047
717962003314	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
717962003315	N- and C-terminal domain interface [polypeptide binding]; other site
717962003316	active site
717962003317	MgATP binding site [chemical binding]; other site
717962003318	catalytic site [active]
717962003319	metal binding site [ion binding]; metal-binding site
717962003320	glycerol binding site [chemical binding]; other site
717962003321	homotetramer interface [polypeptide binding]; other site
717962003322	homodimer interface [polypeptide binding]; other site
717962003323	FBP binding site [chemical binding]; other site
717962003324	protein IIAGlc interface [polypeptide binding]; other site
717962003325	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
717962003326	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
717962003327	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
717962003328	active site
717962003329	ADP/pyrophosphate binding site [chemical binding]; other site
717962003330	dimerization interface [polypeptide binding]; other site
717962003331	allosteric effector site; other site
717962003332	fructose-1,6-bisphosphate binding site; other site
717962003333	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
717962003334	dimer interface [polypeptide binding]; other site
717962003335	substrate binding site [chemical binding]; other site
717962003336	catalytic triad [active]
717962003337	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
717962003338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962003339	dimer interface [polypeptide binding]; other site
717962003340	conserved gate region; other site
717962003341	putative PBP binding loops; other site
717962003342	ABC-ATPase subunit interface; other site
717962003343	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
717962003344	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
717962003345	Walker A/P-loop; other site
717962003346	ATP binding site [chemical binding]; other site
717962003347	Q-loop/lid; other site
717962003348	ABC transporter signature motif; other site
717962003349	Walker B; other site
717962003350	D-loop; other site
717962003351	H-loop/switch region; other site
717962003352	NMT1/THI5 like; Region: NMT1; pfam09084
717962003353	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962003354	substrate binding pocket [chemical binding]; other site
717962003355	membrane-bound complex binding site; other site
717962003356	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
717962003357	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
717962003358	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
717962003359	dimer interface [polypeptide binding]; other site
717962003360	active site
717962003361	Transcriptional regulators [Transcription]; Region: PurR; COG1609
717962003362	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
717962003363	DNA binding site [nucleotide binding]
717962003364	domain linker motif; other site
717962003365	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
717962003366	ligand binding site [chemical binding]; other site
717962003367	dimerization interface [polypeptide binding]; other site
717962003368	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
717962003369	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
717962003370	active site
717962003371	trimer interface [polypeptide binding]; other site
717962003372	allosteric site; other site
717962003373	active site lid [active]
717962003374	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
717962003375	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
717962003376	active site
717962003377	dimer interface [polypeptide binding]; other site
717962003378	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
717962003379	intersubunit interface [polypeptide binding]; other site
717962003380	active site
717962003381	zinc binding site [ion binding]; other site
717962003382	Na+ binding site [ion binding]; other site
717962003383	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
717962003384	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
717962003385	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
717962003386	putative substrate binding site [chemical binding]; other site
717962003387	putative ATP binding site [chemical binding]; other site
717962003388	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
717962003389	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
717962003390	active site
717962003391	phosphorylation site [posttranslational modification]
717962003392	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
717962003393	active site
717962003394	P-loop; other site
717962003395	phosphorylation site [posttranslational modification]
717962003396	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
717962003397	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717962003398	dimerization domain swap beta strand [polypeptide binding]; other site
717962003399	regulatory protein interface [polypeptide binding]; other site
717962003400	active site
717962003401	regulatory phosphorylation site [posttranslational modification]; other site
717962003402	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
717962003403	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
717962003404	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
717962003405	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
717962003406	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
717962003407	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
717962003408	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
717962003409	NAD binding site [chemical binding]; other site
717962003410	dimer interface [polypeptide binding]; other site
717962003411	substrate binding site [chemical binding]; other site
717962003412	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717962003413	NMT1/THI5 like; Region: NMT1; pfam09084
717962003414	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962003415	membrane-bound complex binding site; other site
717962003416	glutamate carboxypeptidase; Reviewed; Region: PRK06133
717962003417	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
717962003418	metal binding site [ion binding]; metal-binding site
717962003419	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
717962003420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962003421	dimer interface [polypeptide binding]; other site
717962003422	conserved gate region; other site
717962003423	putative PBP binding loops; other site
717962003424	ABC-ATPase subunit interface; other site
717962003425	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
717962003426	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
717962003427	Walker A/P-loop; other site
717962003428	ATP binding site [chemical binding]; other site
717962003429	Q-loop/lid; other site
717962003430	ABC transporter signature motif; other site
717962003431	Walker B; other site
717962003432	D-loop; other site
717962003433	H-loop/switch region; other site
717962003434	Putative transcription activator [Transcription]; Region: TenA; COG0819
717962003435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962003436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962003437	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962003438	dimerization interface [polypeptide binding]; other site
717962003439	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
717962003440	gamma subunit interface [polypeptide binding]; other site
717962003441	epsilon subunit interface [polypeptide binding]; other site
717962003442	LBP interface [polypeptide binding]; other site
717962003443	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
717962003444	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
717962003445	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
717962003446	alpha subunit interaction interface [polypeptide binding]; other site
717962003447	Walker A motif; other site
717962003448	ATP binding site [chemical binding]; other site
717962003449	Walker B motif; other site
717962003450	inhibitor binding site; inhibition site
717962003451	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
717962003452	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
717962003453	core domain interface [polypeptide binding]; other site
717962003454	delta subunit interface [polypeptide binding]; other site
717962003455	epsilon subunit interface [polypeptide binding]; other site
717962003456	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
717962003457	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
717962003458	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
717962003459	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
717962003460	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
717962003461	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
717962003462	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
717962003463	MOSC domain; Region: MOSC; pfam03473
717962003464	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
717962003465	trimer interface [polypeptide binding]; other site
717962003466	dimer interface [polypeptide binding]; other site
717962003467	putative active site [active]
717962003468	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
717962003469	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
717962003470	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
717962003471	Transcriptional regulators [Transcription]; Region: GntR; COG1802
717962003472	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962003473	DNA-binding site [nucleotide binding]; DNA binding site
717962003474	FCD domain; Region: FCD; pfam07729
717962003475	Creatinine amidohydrolase; Region: Creatininase; pfam02633
717962003476	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962003477	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
717962003478	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
717962003479	selenophosphate synthetase; Provisional; Region: PRK00943
717962003480	dimerization interface [polypeptide binding]; other site
717962003481	putative ATP binding site [chemical binding]; other site
717962003482	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
717962003483	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
717962003484	CPxP  motif; other site
717962003485	DsrE/DsrF-like family; Region: DrsE; pfam02635
717962003486	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
717962003487	S17 interaction site [polypeptide binding]; other site
717962003488	S8 interaction site; other site
717962003489	16S rRNA interaction site [nucleotide binding]; other site
717962003490	streptomycin interaction site [chemical binding]; other site
717962003491	23S rRNA interaction site [nucleotide binding]; other site
717962003492	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
717962003493	elongation factor Tu; Reviewed; Region: PRK00049
717962003494	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
717962003495	G1 box; other site
717962003496	GEF interaction site [polypeptide binding]; other site
717962003497	GTP/Mg2+ binding site [chemical binding]; other site
717962003498	Switch I region; other site
717962003499	G2 box; other site
717962003500	G3 box; other site
717962003501	Switch II region; other site
717962003502	G4 box; other site
717962003503	G5 box; other site
717962003504	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
717962003505	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
717962003506	Antibiotic Binding Site [chemical binding]; other site
717962003507	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
717962003508	nucleoside/Zn binding site; other site
717962003509	dimer interface [polypeptide binding]; other site
717962003510	catalytic motif [active]
717962003511	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
717962003512	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
717962003513	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717962003514	Walker A/P-loop; other site
717962003515	ATP binding site [chemical binding]; other site
717962003516	Q-loop/lid; other site
717962003517	ABC transporter signature motif; other site
717962003518	Walker B; other site
717962003519	D-loop; other site
717962003520	H-loop/switch region; other site
717962003521	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
717962003522	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717962003523	Walker A/P-loop; other site
717962003524	ATP binding site [chemical binding]; other site
717962003525	Q-loop/lid; other site
717962003526	ABC transporter signature motif; other site
717962003527	Walker B; other site
717962003528	D-loop; other site
717962003529	H-loop/switch region; other site
717962003530	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
717962003531	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
717962003532	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
717962003533	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717962003534	RNA binding surface [nucleotide binding]; other site
717962003535	30S ribosomal protein S11; Validated; Region: PRK05309
717962003536	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
717962003537	30S ribosomal protein S13; Region: bact_S13; TIGR03631
717962003538	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
717962003539	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
717962003540	rRNA binding site [nucleotide binding]; other site
717962003541	predicted 30S ribosome binding site; other site
717962003542	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
717962003543	RNA binding site [nucleotide binding]; other site
717962003544	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
717962003545	active site
717962003546	adenylate kinase; Reviewed; Region: adk; PRK00279
717962003547	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
717962003548	AMP-binding site [chemical binding]; other site
717962003549	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
717962003550	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
717962003551	SecY translocase; Region: SecY; pfam00344
717962003552	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
717962003553	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
717962003554	23S rRNA binding site [nucleotide binding]; other site
717962003555	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
717962003556	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
717962003557	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
717962003558	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
717962003559	5S rRNA interface [nucleotide binding]; other site
717962003560	23S rRNA interface [nucleotide binding]; other site
717962003561	L5 interface [polypeptide binding]; other site
717962003562	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
717962003563	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
717962003564	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
717962003565	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
717962003566	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
717962003567	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
717962003568	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
717962003569	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
717962003570	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
717962003571	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
717962003572	23S rRNA interface [nucleotide binding]; other site
717962003573	5S rRNA interface [nucleotide binding]; other site
717962003574	putative antibiotic binding site [chemical binding]; other site
717962003575	L25 interface [polypeptide binding]; other site
717962003576	L27 interface [polypeptide binding]; other site
717962003577	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
717962003578	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
717962003579	G-X-X-G motif; other site
717962003580	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
717962003581	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
717962003582	protein-rRNA interface [nucleotide binding]; other site
717962003583	putative translocon binding site; other site
717962003584	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
717962003585	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
717962003586	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
717962003587	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
717962003588	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
717962003589	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
717962003590	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
717962003591	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
717962003592	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
717962003593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
717962003594	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
717962003595	classical (c) SDRs; Region: SDR_c; cd05233
717962003596	NAD(P) binding site [chemical binding]; other site
717962003597	active site
717962003598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962003599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962003600	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
717962003601	putative active site [active]
717962003602	putative CoA binding site [chemical binding]; other site
717962003603	nudix motif; other site
717962003604	metal binding site [ion binding]; metal-binding site
717962003605	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
717962003606	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
717962003607	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962003608	FeS/SAM binding site; other site
717962003609	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
717962003610	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
717962003611	ATP cone domain; Region: ATP-cone; pfam03477
717962003612	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
717962003613	Class III ribonucleotide reductase; Region: RNR_III; cd01675
717962003614	active site
717962003615	Zn binding site [ion binding]; other site
717962003616	phosphoglycolate phosphatase; Provisional; Region: PRK13222
717962003617	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962003618	motif II; other site
717962003619	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
717962003620	putative deacylase active site [active]
717962003621	Uncharacterized conserved protein [Function unknown]; Region: COG1284
717962003622	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962003623	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
717962003624	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717962003625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
717962003626	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
717962003627	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
717962003628	nucleotide binding site [chemical binding]; other site
717962003629	substrate binding site [chemical binding]; other site
717962003630	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
717962003631	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
717962003632	hinge; other site
717962003633	active site
717962003634	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
717962003635	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
717962003636	glutaminase active site [active]
717962003637	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
717962003638	dimer interface [polypeptide binding]; other site
717962003639	active site
717962003640	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
717962003641	dimer interface [polypeptide binding]; other site
717962003642	active site
717962003643	SpoVA protein; Region: SpoVA; pfam03862
717962003644	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
717962003645	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
717962003646	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
717962003647	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717962003648	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717962003649	Arginase family; Region: Arginase; cd09989
717962003650	active site
717962003651	Mn binding site [ion binding]; other site
717962003652	oligomer interface [polypeptide binding]; other site
717962003653	Predicted ATPase [General function prediction only]; Region: COG3910
717962003654	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962003655	Walker A/P-loop; other site
717962003656	ATP binding site [chemical binding]; other site
717962003657	ABC transporter signature motif; other site
717962003658	Walker B; other site
717962003659	D-loop; other site
717962003660	H-loop/switch region; other site
717962003661	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
717962003662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962003663	dimer interface [polypeptide binding]; other site
717962003664	conserved gate region; other site
717962003665	putative PBP binding loops; other site
717962003666	ABC-ATPase subunit interface; other site
717962003667	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
717962003668	hinge residues; other site
717962003669	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962003670	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962003671	substrate binding pocket [chemical binding]; other site
717962003672	membrane-bound complex binding site; other site
717962003673	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
717962003674	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
717962003675	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717962003676	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717962003677	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
717962003678	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
717962003679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962003680	ATP binding site [chemical binding]; other site
717962003681	Mg2+ binding site [ion binding]; other site
717962003682	G-X-G motif; other site
717962003683	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
717962003684	anti sigma factor interaction site; other site
717962003685	regulatory phosphorylation site [posttranslational modification]; other site
717962003686	TPR repeat; Region: TPR_11; pfam13414
717962003687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717962003688	TPR motif; other site
717962003689	binding surface
717962003690	Tetratricopeptide repeat; Region: TPR_16; pfam13432
717962003691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
717962003692	Tetratricopeptide repeat; Region: TPR_6; pfam13174
717962003693	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
717962003694	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717962003695	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717962003696	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
717962003697	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717962003698	active site
717962003699	HIGH motif; other site
717962003700	nucleotide binding site [chemical binding]; other site
717962003701	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
717962003702	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
717962003703	active site
717962003704	KMSKS motif; other site
717962003705	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
717962003706	tRNA binding surface [nucleotide binding]; other site
717962003707	anticodon binding site; other site
717962003708	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
717962003709	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
717962003710	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
717962003711	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
717962003712	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
717962003713	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
717962003714	putative NAD(P) binding site [chemical binding]; other site
717962003715	catalytic Zn binding site [ion binding]; other site
717962003716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
717962003717	Putative esterase; Region: Esterase; pfam00756
717962003718	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
717962003719	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
717962003720	GDP-binding site [chemical binding]; other site
717962003721	ACT binding site; other site
717962003722	IMP binding site; other site
717962003723	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962003724	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962003725	non-specific DNA binding site [nucleotide binding]; other site
717962003726	salt bridge; other site
717962003727	sequence-specific DNA binding site [nucleotide binding]; other site
717962003728	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
717962003729	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
717962003730	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
717962003731	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
717962003732	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717962003733	substrate binding site [chemical binding]; other site
717962003734	oxyanion hole (OAH) forming residues; other site
717962003735	trimer interface [polypeptide binding]; other site
717962003736	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
717962003737	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717962003738	active site
717962003739	metal binding site [ion binding]; metal-binding site
717962003740	homotetramer interface [polypeptide binding]; other site
717962003741	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
717962003742	active site
717962003743	dimerization interface [polypeptide binding]; other site
717962003744	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
717962003745	active site
717962003746	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
717962003747	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
717962003748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
717962003749	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
717962003750	active site residue [active]
717962003751	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962003752	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962003753	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
717962003754	dimerization interface [polypeptide binding]; other site
717962003755	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
717962003756	fructuronate transporter; Provisional; Region: PRK10034; cl15264
717962003757	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
717962003758	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
717962003759	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
717962003760	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
717962003761	dimer interaction site [polypeptide binding]; other site
717962003762	substrate-binding tunnel; other site
717962003763	active site
717962003764	catalytic site [active]
717962003765	substrate binding site [chemical binding]; other site
717962003766	Protein of unknown function (DUF975); Region: DUF975; cl10504
717962003767	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
717962003768	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962003769	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962003770	metal binding site [ion binding]; metal-binding site
717962003771	active site
717962003772	I-site; other site
717962003773	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962003774	metal binding site [ion binding]; metal-binding site
717962003775	active site
717962003776	I-site; other site
717962003777	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
717962003778	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
717962003779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962003780	active site
717962003781	phosphorylation site [posttranslational modification]
717962003782	intermolecular recognition site; other site
717962003783	dimerization interface [polypeptide binding]; other site
717962003784	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962003785	Zn2+ binding site [ion binding]; other site
717962003786	Mg2+ binding site [ion binding]; other site
717962003787	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962003788	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962003789	metal binding site [ion binding]; metal-binding site
717962003790	active site
717962003791	I-site; other site
717962003792	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962003793	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962003794	metal binding site [ion binding]; metal-binding site
717962003795	active site
717962003796	I-site; other site
717962003797	Transcriptional regulators [Transcription]; Region: FadR; COG2186
717962003798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962003799	DNA-binding site [nucleotide binding]; DNA binding site
717962003800	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
717962003801	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
717962003802	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962003803	active site
717962003804	motif I; other site
717962003805	motif II; other site
717962003806	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
717962003807	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962003808	active site
717962003809	motif I; other site
717962003810	motif II; other site
717962003811	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717962003812	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
717962003813	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
717962003814	putative active site [active]
717962003815	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
717962003816	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
717962003817	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
717962003818	dimer interface [polypeptide binding]; other site
717962003819	ssDNA binding site [nucleotide binding]; other site
717962003820	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717962003821	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
717962003822	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
717962003823	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
717962003824	dimer interface [polypeptide binding]; other site
717962003825	active site
717962003826	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
717962003827	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
717962003828	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
717962003829	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
717962003830	classical (c) SDRs; Region: SDR_c; cd05233
717962003831	NAD(P) binding site [chemical binding]; other site
717962003832	active site
717962003833	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
717962003834	active site
717962003835	substrate binding pocket [chemical binding]; other site
717962003836	homodimer interaction site [polypeptide binding]; other site
717962003837	Major Facilitator Superfamily; Region: MFS_1; pfam07690
717962003838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717962003839	putative substrate translocation pore; other site
717962003840	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717962003841	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962003842	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
717962003843	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717962003844	substrate binding site [chemical binding]; other site
717962003845	oxyanion hole (OAH) forming residues; other site
717962003846	trimer interface [polypeptide binding]; other site
717962003847	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
717962003848	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717962003849	substrate binding site [chemical binding]; other site
717962003850	oxyanion hole (OAH) forming residues; other site
717962003851	trimer interface [polypeptide binding]; other site
717962003852	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962003853	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962003854	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962003855	dimerization interface [polypeptide binding]; other site
717962003856	Uncharacterized conserved protein [Function unknown]; Region: COG2006
717962003857	Domain of unknown function (DUF362); Region: DUF362; pfam04015
717962003858	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
717962003859	Coenzyme A transferase; Region: CoA_trans; cl17247
717962003860	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
717962003861	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
717962003862	L-lactate permease; Region: Lactate_perm; cl00701
717962003863	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
717962003864	DJ-1 family protein; Region: not_thiJ; TIGR01383
717962003865	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
717962003866	conserved cys residue [active]
717962003867	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
717962003868	DHH family; Region: DHH; pfam01368
717962003869	DHHA1 domain; Region: DHHA1; pfam02272
717962003870	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
717962003871	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
717962003872	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
717962003873	replicative DNA helicase; Region: DnaB; TIGR00665
717962003874	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
717962003875	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
717962003876	Walker A motif; other site
717962003877	ATP binding site [chemical binding]; other site
717962003878	Walker B motif; other site
717962003879	DNA binding loops [nucleotide binding]
717962003880	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764
717962003881	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
717962003882	DNA binding residues [nucleotide binding]
717962003883	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
717962003884	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
717962003885	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717962003886	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
717962003887	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
717962003888	active site
717962003889	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
717962003890	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962003891	FeS/SAM binding site; other site
717962003892	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
717962003893	dimer interface [polypeptide binding]; other site
717962003894	pyridoxal binding site [chemical binding]; other site
717962003895	ATP binding site [chemical binding]; other site
717962003896	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
717962003897	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
717962003898	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
717962003899	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962003900	active site
717962003901	DNA replication protein DnaC; Validated; Region: PRK06835
717962003902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962003903	Walker A motif; other site
717962003904	ATP binding site [chemical binding]; other site
717962003905	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
717962003906	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
717962003907	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
717962003908	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
717962003909	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717962003910	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717962003911	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
717962003912	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
717962003913	ligand binding site; other site
717962003914	oligomer interface; other site
717962003915	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
717962003916	dimer interface [polypeptide binding]; other site
717962003917	N-terminal domain interface [polypeptide binding]; other site
717962003918	sulfate 1 binding site; other site
717962003919	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
717962003920	putative active site [active]
717962003921	catalytic residue [active]
717962003922	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
717962003923	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
717962003924	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717962003925	ATP binding site [chemical binding]; other site
717962003926	putative Mg++ binding site [ion binding]; other site
717962003927	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717962003928	nucleotide binding region [chemical binding]; other site
717962003929	ATP-binding site [chemical binding]; other site
717962003930	TRCF domain; Region: TRCF; pfam03461
717962003931	TIR domain; Region: TIR_2; cl17458
717962003932	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
717962003933	Sel1-like repeats; Region: SEL1; smart00671
717962003934	Sel1-like repeats; Region: SEL1; smart00671
717962003935	Sel1-like repeats; Region: SEL1; smart00671
717962003936	Sel1-like repeats; Region: SEL1; smart00671
717962003937	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
717962003938	putative active site [active]
717962003939	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
717962003940	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
717962003941	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
717962003942	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
717962003943	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
717962003944	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
717962003945	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
717962003946	ApbE family; Region: ApbE; pfam02424
717962003947	FMN-binding domain; Region: FMN_bind; cl01081
717962003948	FMN-binding domain; Region: FMN_bind; cl01081
717962003949	FMN-binding domain; Region: FMN_bind; cl01081
717962003950	FMN-binding domain; Region: FMN_bind; cl01081
717962003951	FMN-binding domain; Region: FMN_bind; cl01081
717962003952	FMN-binding domain; Region: FMN_bind; cl01081
717962003953	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717962003954	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
717962003955	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
717962003956	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
717962003957	Cupin domain; Region: Cupin_2; cl17218
717962003958	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
717962003959	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
717962003960	active site
717962003961	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
717962003962	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
717962003963	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
717962003964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962003965	Coenzyme A binding pocket [chemical binding]; other site
717962003966	prolyl-tRNA synthetase; Provisional; Region: PRK08661
717962003967	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
717962003968	dimer interface [polypeptide binding]; other site
717962003969	motif 1; other site
717962003970	active site
717962003971	motif 2; other site
717962003972	motif 3; other site
717962003973	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
717962003974	anticodon binding site; other site
717962003975	zinc-binding site [ion binding]; other site
717962003976	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962003977	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962003978	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
717962003979	dimerization interface [polypeptide binding]; other site
717962003980	substrate binding pocket [chemical binding]; other site
717962003981	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
717962003982	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
717962003983	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
717962003984	transmembrane helices; other site
717962003985	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
717962003986	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
717962003987	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
717962003988	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962003989	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962003990	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
717962003991	dimerization interface [polypeptide binding]; other site
717962003992	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717962003993	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962003994	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
717962003995	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
717962003996	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962003997	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
717962003998	L-lactate permease; Region: Lactate_perm; cl00701
717962003999	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
717962004000	Coenzyme A transferase; Region: CoA_trans; smart00882
717962004001	Coenzyme A transferase; Region: CoA_trans; cl17247
717962004002	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
717962004003	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
717962004004	active site
717962004005	Uncharacterized conserved protein [Function unknown]; Region: COG1284
717962004006	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962004007	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
717962004008	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
717962004009	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
717962004010	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
717962004011	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
717962004012	catalytic loop [active]
717962004013	iron binding site [ion binding]; other site
717962004014	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
717962004015	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
717962004016	FAD binding pocket [chemical binding]; other site
717962004017	FAD binding motif [chemical binding]; other site
717962004018	phosphate binding motif [ion binding]; other site
717962004019	beta-alpha-beta structure motif; other site
717962004020	NAD binding pocket [chemical binding]; other site
717962004021	Iron coordination center [ion binding]; other site
717962004022	putative oxidoreductase; Provisional; Region: PRK12831
717962004023	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717962004024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717962004025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717962004026	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
717962004027	Nitrogen regulatory protein P-II; Region: P-II; smart00938
717962004028	PAS domain; Region: PAS_9; pfam13426
717962004029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962004030	putative active site [active]
717962004031	heme pocket [chemical binding]; other site
717962004032	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962004033	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962004034	Walker A motif; other site
717962004035	ATP binding site [chemical binding]; other site
717962004036	Walker B motif; other site
717962004037	arginine finger; other site
717962004038	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962004039	putative acyltransferase; Provisional; Region: PRK05790
717962004040	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
717962004041	dimer interface [polypeptide binding]; other site
717962004042	active site
717962004043	oligoendopeptidase F; Region: pepF; TIGR00181
717962004044	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
717962004045	active site
717962004046	Zn binding site [ion binding]; other site
717962004047	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962004048	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962004049	Walker A/P-loop; other site
717962004050	ATP binding site [chemical binding]; other site
717962004051	Q-loop/lid; other site
717962004052	ABC transporter signature motif; other site
717962004053	Walker B; other site
717962004054	D-loop; other site
717962004055	H-loop/switch region; other site
717962004056	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717962004057	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
717962004058	FtsX-like permease family; Region: FtsX; pfam02687
717962004059	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
717962004060	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717962004061	FtsX-like permease family; Region: FtsX; pfam02687
717962004062	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717962004063	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
717962004064	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717962004065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962004066	dimer interface [polypeptide binding]; other site
717962004067	conserved gate region; other site
717962004068	putative PBP binding loops; other site
717962004069	ABC-ATPase subunit interface; other site
717962004070	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
717962004071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962004072	dimer interface [polypeptide binding]; other site
717962004073	conserved gate region; other site
717962004074	putative PBP binding loops; other site
717962004075	ABC-ATPase subunit interface; other site
717962004076	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
717962004077	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962004078	Walker A/P-loop; other site
717962004079	ATP binding site [chemical binding]; other site
717962004080	Q-loop/lid; other site
717962004081	ABC transporter signature motif; other site
717962004082	Walker B; other site
717962004083	D-loop; other site
717962004084	H-loop/switch region; other site
717962004085	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717962004086	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962004087	Walker A/P-loop; other site
717962004088	ATP binding site [chemical binding]; other site
717962004089	Q-loop/lid; other site
717962004090	ABC transporter signature motif; other site
717962004091	Walker B; other site
717962004092	D-loop; other site
717962004093	H-loop/switch region; other site
717962004094	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717962004095	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
717962004096	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
717962004097	dimerization interface 3.5A [polypeptide binding]; other site
717962004098	active site
717962004099	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
717962004100	active site
717962004101	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
717962004102	S1 domain; Region: S1_2; pfam13509
717962004103	S1 domain; Region: S1_2; pfam13509
717962004104	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
717962004105	RNA binding site [nucleotide binding]; other site
717962004106	Bacterial SH3 domain; Region: SH3_3; cl17532
717962004107	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962004108	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962004109	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962004110	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717962004111	NlpC/P60 family; Region: NLPC_P60; pfam00877
717962004112	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
717962004113	30S subunit binding site; other site
717962004114	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
717962004115	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
717962004116	ATP binding site [chemical binding]; other site
717962004117	putative Mg++ binding site [ion binding]; other site
717962004118	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
717962004119	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717962004120	nucleotide binding region [chemical binding]; other site
717962004121	ATP-binding site [chemical binding]; other site
717962004122	SEC-C motif; Region: SEC-C; pfam02810
717962004123	peptide chain release factor 2; Provisional; Region: PRK05589
717962004124	PCRF domain; Region: PCRF; pfam03462
717962004125	RF-1 domain; Region: RF-1; pfam00472
717962004126	hypothetical protein; Provisional; Region: PRK04435
717962004127	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
717962004128	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
717962004129	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
717962004130	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
717962004131	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
717962004132	RNA binding site [nucleotide binding]; other site
717962004133	YcxB-like protein; Region: YcxB; pfam14317
717962004134	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
717962004135	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
717962004136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962004137	Coenzyme A binding pocket [chemical binding]; other site
717962004138	ribonuclease Z; Region: RNase_Z; TIGR02651
717962004139	UGMP family protein; Validated; Region: PRK09604
717962004140	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
717962004141	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
717962004142	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
717962004143	substrate binding site; other site
717962004144	dimer interface; other site
717962004145	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
717962004146	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
717962004147	active site
717962004148	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
717962004149	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
717962004150	catalytic motif [active]
717962004151	Zn binding site [ion binding]; other site
717962004152	RibD C-terminal domain; Region: RibD_C; cl17279
717962004153	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
717962004154	Lumazine binding domain; Region: Lum_binding; pfam00677
717962004155	Lumazine binding domain; Region: Lum_binding; pfam00677
717962004156	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
717962004157	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
717962004158	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
717962004159	dimerization interface [polypeptide binding]; other site
717962004160	active site
717962004161	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
717962004162	homopentamer interface [polypeptide binding]; other site
717962004163	active site
717962004164	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
717962004165	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
717962004166	Walker A/P-loop; other site
717962004167	ATP binding site [chemical binding]; other site
717962004168	Q-loop/lid; other site
717962004169	ABC transporter signature motif; other site
717962004170	Walker B; other site
717962004171	D-loop; other site
717962004172	H-loop/switch region; other site
717962004173	TOBE domain; Region: TOBE_2; pfam08402
717962004174	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
717962004175	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
717962004176	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
717962004177	SLBB domain; Region: SLBB; pfam10531
717962004178	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
717962004179	FMN-binding domain; Region: FMN_bind; cl01081
717962004180	electron transport complex RsxE subunit; Provisional; Region: PRK12405
717962004181	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
717962004182	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
717962004183	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
717962004184	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
717962004185	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717962004186	4Fe-4S binding domain; Region: Fer4; cl02805
717962004187	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962004188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962004189	active site
717962004190	phosphorylation site [posttranslational modification]
717962004191	intermolecular recognition site; other site
717962004192	dimerization interface [polypeptide binding]; other site
717962004193	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962004194	DNA binding site [nucleotide binding]
717962004195	Transcriptional regulators [Transcription]; Region: FadR; COG2186
717962004196	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962004197	DNA-binding site [nucleotide binding]; DNA binding site
717962004198	FCD domain; Region: FCD; pfam07729
717962004199	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
717962004200	FAD binding domain; Region: FAD_binding_4; pfam01565
717962004201	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
717962004202	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
717962004203	FAD binding site [chemical binding]; other site
717962004204	homotetramer interface [polypeptide binding]; other site
717962004205	substrate binding pocket [chemical binding]; other site
717962004206	catalytic base [active]
717962004207	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
717962004208	Ligand binding site [chemical binding]; other site
717962004209	Electron transfer flavoprotein domain; Region: ETF; pfam01012
717962004210	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
717962004211	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
717962004212	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
717962004213	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717962004214	dimerization domain swap beta strand [polypeptide binding]; other site
717962004215	regulatory protein interface [polypeptide binding]; other site
717962004216	active site
717962004217	regulatory phosphorylation site [posttranslational modification]; other site
717962004218	acyl carrier protein; Provisional; Region: acpP; PRK00982
717962004219	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962004220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962004221	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
717962004222	dimerization interface [polypeptide binding]; other site
717962004223	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
717962004224	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
717962004225	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
717962004226	putative RNA binding site [nucleotide binding]; other site
717962004227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962004228	S-adenosylmethionine binding site [chemical binding]; other site
717962004229	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
717962004230	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717962004231	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717962004232	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
717962004233	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
717962004234	dihydropteroate synthase; Region: DHPS; TIGR01496
717962004235	substrate binding pocket [chemical binding]; other site
717962004236	dimer interface [polypeptide binding]; other site
717962004237	inhibitor binding site; inhibition site
717962004238	exopolyphosphatase; Region: exo_poly_only; TIGR03706
717962004239	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
717962004240	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962004241	Zn2+ binding site [ion binding]; other site
717962004242	Mg2+ binding site [ion binding]; other site
717962004243	polyphosphate kinase; Provisional; Region: PRK05443
717962004244	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
717962004245	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
717962004246	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
717962004247	putative domain interface [polypeptide binding]; other site
717962004248	putative active site [active]
717962004249	catalytic site [active]
717962004250	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
717962004251	putative domain interface [polypeptide binding]; other site
717962004252	putative active site [active]
717962004253	catalytic site [active]
717962004254	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
717962004255	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
717962004256	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
717962004257	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
717962004258	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
717962004259	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
717962004260	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
717962004261	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
717962004262	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
717962004263	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
717962004264	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
717962004265	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
717962004266	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
717962004267	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
717962004268	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
717962004269	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
717962004270	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
717962004271	minor groove reading motif; other site
717962004272	helix-hairpin-helix signature motif; other site
717962004273	substrate binding pocket [chemical binding]; other site
717962004274	active site
717962004275	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
717962004276	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
717962004277	DNA binding and oxoG recognition site [nucleotide binding]
717962004278	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
717962004279	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962004280	Zn2+ binding site [ion binding]; other site
717962004281	Mg2+ binding site [ion binding]; other site
717962004282	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
717962004283	DNA primase; Validated; Region: dnaG; PRK05667
717962004284	CHC2 zinc finger; Region: zf-CHC2; pfam01807
717962004285	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
717962004286	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
717962004287	active site
717962004288	metal binding site [ion binding]; metal-binding site
717962004289	interdomain interaction site; other site
717962004290	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
717962004291	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
717962004292	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
717962004293	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962004294	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
717962004295	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962004296	DNA binding residues [nucleotide binding]
717962004297	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
717962004298	Family of unknown function (DUF633); Region: DUF633; pfam04816
717962004299	Uncharacterized conserved protein [Function unknown]; Region: COG0327
717962004300	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
717962004301	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
717962004302	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
717962004303	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
717962004304	active site
717962004305	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962004306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962004307	active site
717962004308	phosphorylation site [posttranslational modification]
717962004309	intermolecular recognition site; other site
717962004310	dimerization interface [polypeptide binding]; other site
717962004311	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962004312	DNA binding site [nucleotide binding]
717962004313	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962004314	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717962004315	Walker A/P-loop; other site
717962004316	ATP binding site [chemical binding]; other site
717962004317	Q-loop/lid; other site
717962004318	ABC transporter signature motif; other site
717962004319	Walker B; other site
717962004320	D-loop; other site
717962004321	H-loop/switch region; other site
717962004322	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
717962004323	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
717962004324	recombinase A; Provisional; Region: recA; PRK09354
717962004325	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
717962004326	hexamer interface [polypeptide binding]; other site
717962004327	Walker A motif; other site
717962004328	ATP binding site [chemical binding]; other site
717962004329	Walker B motif; other site
717962004330	recombination regulator RecX; Reviewed; Region: recX; PRK00117
717962004331	Predicted permeases [General function prediction only]; Region: COG0679
717962004332	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
717962004333	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
717962004334	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
717962004335	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
717962004336	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
717962004337	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
717962004338	catalytic loop [active]
717962004339	iron binding site [ion binding]; other site
717962004340	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
717962004341	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
717962004342	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
717962004343	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
717962004344	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
717962004345	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
717962004346	Ligand binding site; other site
717962004347	metal-binding site
717962004348	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
717962004349	putative MPT binding site; other site
717962004350	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962004351	active site
717962004352	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962004353	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962004354	active site
717962004355	phosphorylation site [posttranslational modification]
717962004356	intermolecular recognition site; other site
717962004357	dimerization interface [polypeptide binding]; other site
717962004358	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962004359	DNA binding site [nucleotide binding]
717962004360	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962004361	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717962004362	dimerization interface [polypeptide binding]; other site
717962004363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962004364	dimer interface [polypeptide binding]; other site
717962004365	phosphorylation site [posttranslational modification]
717962004366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962004367	ATP binding site [chemical binding]; other site
717962004368	Mg2+ binding site [ion binding]; other site
717962004369	G-X-G motif; other site
717962004370	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
717962004371	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
717962004372	putative active site [active]
717962004373	oxyanion strand; other site
717962004374	catalytic triad [active]
717962004375	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
717962004376	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
717962004377	substrate binding site [chemical binding]; other site
717962004378	glutamase interaction surface [polypeptide binding]; other site
717962004379	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
717962004380	ligand binding site [chemical binding]; other site
717962004381	active site
717962004382	UGI interface [polypeptide binding]; other site
717962004383	catalytic site [active]
717962004384	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
717962004385	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
717962004386	Ca binding site [ion binding]; other site
717962004387	active site
717962004388	catalytic site [active]
717962004389	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717962004390	nucleotide binding site [chemical binding]; other site
717962004391	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
717962004392	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717962004393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
717962004394	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717962004395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
717962004396	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
717962004397	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717962004398	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717962004399	Rhomboid family; Region: Rhomboid; cl11446
717962004400	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
717962004401	Uncharacterized conserved protein [Function unknown]; Region: COG3874
717962004402	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
717962004403	phosphopeptide binding site; other site
717962004404	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
717962004405	Asp23 family; Region: Asp23; pfam03780
717962004406	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
717962004407	Y-family of DNA polymerases; Region: PolY; cl12025
717962004408	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
717962004409	ssDNA binding site; other site
717962004410	generic binding surface II; other site
717962004411	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717962004412	ATP binding site [chemical binding]; other site
717962004413	putative Mg++ binding site [ion binding]; other site
717962004414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717962004415	nucleotide binding region [chemical binding]; other site
717962004416	ATP-binding site [chemical binding]; other site
717962004417	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
717962004418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962004419	S-adenosylmethionine binding site [chemical binding]; other site
717962004420	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
717962004421	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
717962004422	active site
717962004423	(T/H)XGH motif; other site
717962004424	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
717962004425	Nucleoside recognition; Region: Gate; pfam07670
717962004426	hypothetical protein; Provisional; Region: PRK13670
717962004427	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
717962004428	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
717962004429	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
717962004430	Predicted secreted protein [Function unknown]; Region: COG4086
717962004431	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
717962004432	putative phosphate acyltransferase; Provisional; Region: PRK05331
717962004433	ribonuclease III; Reviewed; Region: rnc; PRK00102
717962004434	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
717962004435	dimerization interface [polypeptide binding]; other site
717962004436	active site
717962004437	metal binding site [ion binding]; metal-binding site
717962004438	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
717962004439	dsRNA binding site [nucleotide binding]; other site
717962004440	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
717962004441	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
717962004442	Walker A/P-loop; other site
717962004443	ATP binding site [chemical binding]; other site
717962004444	Q-loop/lid; other site
717962004445	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
717962004446	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
717962004447	ABC transporter signature motif; other site
717962004448	Walker B; other site
717962004449	D-loop; other site
717962004450	H-loop/switch region; other site
717962004451	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
717962004452	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
717962004453	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962004454	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
717962004455	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
717962004456	acyl-activating enzyme (AAE) consensus motif; other site
717962004457	AMP binding site [chemical binding]; other site
717962004458	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
717962004459	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
717962004460	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717962004461	catalytic residue [active]
717962004462	Phosphopantetheine attachment site; Region: PP-binding; cl09936
717962004463	acyl carrier protein; Provisional; Region: PRK07081
717962004464	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
717962004465	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962004466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962004467	active site
717962004468	phosphorylation site [posttranslational modification]
717962004469	intermolecular recognition site; other site
717962004470	dimerization interface [polypeptide binding]; other site
717962004471	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962004472	DNA binding site [nucleotide binding]
717962004473	putative DNA-binding protein; Validated; Region: PRK00118
717962004474	signal recognition particle protein; Provisional; Region: PRK10867
717962004475	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
717962004476	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
717962004477	P loop; other site
717962004478	GTP binding site [chemical binding]; other site
717962004479	Signal peptide binding domain; Region: SRP_SPB; pfam02978
717962004480	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
717962004481	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
717962004482	hypothetical protein; Provisional; Region: PRK00468
717962004483	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
717962004484	RimM N-terminal domain; Region: RimM; pfam01782
717962004485	PRC-barrel domain; Region: PRC; pfam05239
717962004486	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
717962004487	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
717962004488	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
717962004489	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
717962004490	Catalytic site [active]
717962004491	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
717962004492	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
717962004493	GTP/Mg2+ binding site [chemical binding]; other site
717962004494	G4 box; other site
717962004495	G5 box; other site
717962004496	G1 box; other site
717962004497	Switch I region; other site
717962004498	G2 box; other site
717962004499	G3 box; other site
717962004500	Switch II region; other site
717962004501	hypothetical protein; Reviewed; Region: PRK12497
717962004502	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
717962004503	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
717962004504	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
717962004505	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
717962004506	Protein of unknown function (DUF512); Region: DUF512; pfam04459
717962004507	GTP-binding protein Der; Reviewed; Region: PRK00093
717962004508	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
717962004509	G1 box; other site
717962004510	GTP/Mg2+ binding site [chemical binding]; other site
717962004511	Switch I region; other site
717962004512	G2 box; other site
717962004513	Switch II region; other site
717962004514	G3 box; other site
717962004515	G4 box; other site
717962004516	G5 box; other site
717962004517	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
717962004518	G1 box; other site
717962004519	GTP/Mg2+ binding site [chemical binding]; other site
717962004520	Switch I region; other site
717962004521	G2 box; other site
717962004522	G3 box; other site
717962004523	Switch II region; other site
717962004524	G4 box; other site
717962004525	G5 box; other site
717962004526	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
717962004527	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
717962004528	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
717962004529	G1 box; other site
717962004530	GTP/Mg2+ binding site [chemical binding]; other site
717962004531	G2 box; other site
717962004532	Switch I region; other site
717962004533	G3 box; other site
717962004534	Switch II region; other site
717962004535	G4 box; other site
717962004536	G5 box; other site
717962004537	Predicted integral membrane protein [Function unknown]; Region: COG5652
717962004538	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
717962004539	RNA/DNA hybrid binding site [nucleotide binding]; other site
717962004540	active site
717962004541	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
717962004542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962004543	S-adenosylmethionine binding site [chemical binding]; other site
717962004544	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
717962004545	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
717962004546	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717962004547	RNA binding surface [nucleotide binding]; other site
717962004548	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
717962004549	active site
717962004550	uracil binding [chemical binding]; other site
717962004551	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
717962004552	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962004553	motif II; other site
717962004554	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
717962004555	hypothetical protein; Provisional; Region: PRK00955
717962004556	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
717962004557	Recombination protein U; Region: RecU; pfam03838
717962004558	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
717962004559	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
717962004560	dimer interface [polypeptide binding]; other site
717962004561	motif 1; other site
717962004562	active site
717962004563	motif 2; other site
717962004564	motif 3; other site
717962004565	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
717962004566	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
717962004567	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
717962004568	histidinol dehydrogenase; Region: hisD; TIGR00069
717962004569	NAD binding site [chemical binding]; other site
717962004570	dimerization interface [polypeptide binding]; other site
717962004571	product binding site; other site
717962004572	substrate binding site [chemical binding]; other site
717962004573	zinc binding site [ion binding]; other site
717962004574	catalytic residues [active]
717962004575	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
717962004576	putative active site pocket [active]
717962004577	4-fold oligomerization interface [polypeptide binding]; other site
717962004578	metal binding residues [ion binding]; metal-binding site
717962004579	3-fold/trimer interface [polypeptide binding]; other site
717962004580	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
717962004581	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
717962004582	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
717962004583	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
717962004584	metal binding site [ion binding]; metal-binding site
717962004585	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
717962004586	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
717962004587	motif 1; other site
717962004588	active site
717962004589	motif 2; other site
717962004590	motif 3; other site
717962004591	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
717962004592	DHHA1 domain; Region: DHHA1; pfam02272
717962004593	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
717962004594	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
717962004595	putative active site [active]
717962004596	putative metal binding site [ion binding]; other site
717962004597	selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311
717962004598	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
717962004599	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
717962004600	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
717962004601	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
717962004602	ferredoxin; Validated; Region: PRK07118
717962004603	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
717962004604	Domain of unknown function, E. rectale Gene description (DUF3878); Region: DUF3878; pfam12994
717962004605	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
717962004606	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962004607	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717962004608	Walker A/P-loop; other site
717962004609	ATP binding site [chemical binding]; other site
717962004610	Q-loop/lid; other site
717962004611	ABC transporter signature motif; other site
717962004612	Walker B; other site
717962004613	D-loop; other site
717962004614	H-loop/switch region; other site
717962004615	YabP family; Region: YabP; pfam07873
717962004616	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
717962004617	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
717962004618	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
717962004619	PhoH-like protein; Region: PhoH; pfam02562
717962004620	metal-binding heat shock protein; Provisional; Region: PRK00016
717962004621	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
717962004622	stage V sporulation protein B; Region: spore_V_B; TIGR02900
717962004623	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
717962004624	flavoprotein, HI0933 family; Region: TIGR00275
717962004625	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
717962004626	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717962004627	gamma-glutamyl kinase; Provisional; Region: PRK05429
717962004628	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
717962004629	nucleotide binding site [chemical binding]; other site
717962004630	homotetrameric interface [polypeptide binding]; other site
717962004631	putative phosphate binding site [ion binding]; other site
717962004632	putative allosteric binding site; other site
717962004633	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
717962004634	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
717962004635	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
717962004636	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
717962004637	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
717962004638	putative catalytic cysteine [active]
717962004639	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
717962004640	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
717962004641	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962004642	FeS/SAM binding site; other site
717962004643	TRAM domain; Region: TRAM; pfam01938
717962004644	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
717962004645	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
717962004646	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
717962004647	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
717962004648	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
717962004649	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962004650	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717962004651	Walker A/P-loop; other site
717962004652	ATP binding site [chemical binding]; other site
717962004653	Q-loop/lid; other site
717962004654	ABC transporter signature motif; other site
717962004655	Walker B; other site
717962004656	D-loop; other site
717962004657	H-loop/switch region; other site
717962004658	HD domain; Region: HD_4; pfam13328
717962004659	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
717962004660	MutS domain I; Region: MutS_I; pfam01624
717962004661	MutS domain II; Region: MutS_II; pfam05188
717962004662	MutS domain III; Region: MutS_III; pfam05192
717962004663	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
717962004664	Walker A/P-loop; other site
717962004665	ATP binding site [chemical binding]; other site
717962004666	Q-loop/lid; other site
717962004667	ABC transporter signature motif; other site
717962004668	Walker B; other site
717962004669	D-loop; other site
717962004670	H-loop/switch region; other site
717962004671	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
717962004672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962004673	ATP binding site [chemical binding]; other site
717962004674	Mg2+ binding site [ion binding]; other site
717962004675	G-X-G motif; other site
717962004676	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
717962004677	ATP binding site [chemical binding]; other site
717962004678	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
717962004679	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
717962004680	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
717962004681	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
717962004682	Aluminium resistance protein; Region: Alum_res; pfam06838
717962004683	hypothetical protein; Reviewed; Region: PRK00024
717962004684	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
717962004685	MPN+ (JAMM) motif; other site
717962004686	Zinc-binding site [ion binding]; other site
717962004687	rod shape-determining protein MreC; Provisional; Region: PRK13922
717962004688	rod shape-determining protein MreC; Region: MreC; pfam04085
717962004689	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
717962004690	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
717962004691	P-loop; other site
717962004692	ADP binding residues [chemical binding]; other site
717962004693	Switch I; other site
717962004694	Switch II; other site
717962004695	Septum formation topological specificity factor MinE; Region: MinE; cl00538
717962004696	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
717962004697	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
717962004698	substrate binding site [chemical binding]; other site
717962004699	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
717962004700	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717962004701	Domain of unknown function (DUF378); Region: DUF378; cl00943
717962004702	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
717962004703	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962004704	FeS/SAM binding site; other site
717962004705	HlyD family secretion protein; Region: HlyD_2; pfam12700
717962004706	putative membrane fusion protein; Region: TIGR02828
717962004707	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
717962004708	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717962004709	catalytic residue [active]
717962004710	Protein of unknown function (DUF552); Region: DUF552; pfam04472
717962004711	DivIVA protein; Region: DivIVA; pfam05103
717962004712	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
717962004713	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
717962004714	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
717962004715	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
717962004716	ABC1 family; Region: ABC1; cl17513
717962004717	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
717962004718	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
717962004719	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
717962004720	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717962004721	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
717962004722	putative lipid kinase; Reviewed; Region: PRK13337
717962004723	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
717962004724	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
717962004725	putative active site [active]
717962004726	putative metal binding site [ion binding]; other site
717962004727	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
717962004728	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
717962004729	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
717962004730	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
717962004731	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
717962004732	conserved cys residue [active]
717962004733	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717962004734	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
717962004735	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
717962004736	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
717962004737	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
717962004738	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
717962004739	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
717962004740	carboxyltransferase (CT) interaction site; other site
717962004741	biotinylation site [posttranslational modification]; other site
717962004742	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
717962004743	oxaloacetate decarboxylase; Provisional; Region: PRK12331
717962004744	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
717962004745	active site
717962004746	catalytic residues [active]
717962004747	metal binding site [ion binding]; metal-binding site
717962004748	homodimer binding site [polypeptide binding]; other site
717962004749	putative acyltransferase; Provisional; Region: PRK05790
717962004750	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
717962004751	dimer interface [polypeptide binding]; other site
717962004752	active site
717962004753	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
717962004754	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
717962004755	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
717962004756	putative active site [active]
717962004757	flavoprotein, HI0933 family; Region: TIGR00275
717962004758	cytidylate kinase; Provisional; Region: cmk; PRK00023
717962004759	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
717962004760	CMP-binding site; other site
717962004761	The sites determining sugar specificity; other site
717962004762	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
717962004763	LytB protein; Region: LYTB; cl00507
717962004764	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
717962004765	RNA binding site [nucleotide binding]; other site
717962004766	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
717962004767	RNA binding site [nucleotide binding]; other site
717962004768	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
717962004769	RNA binding site [nucleotide binding]; other site
717962004770	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
717962004771	RNA binding site [nucleotide binding]; other site
717962004772	RNase_H superfamily; Region: RNase_H_2; pfam13482
717962004773	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
717962004774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962004775	Walker A motif; other site
717962004776	ATP binding site [chemical binding]; other site
717962004777	Walker B motif; other site
717962004778	arginine finger; other site
717962004779	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
717962004780	Cell division protein ZapA; Region: ZapA; pfam05164
717962004781	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
717962004782	Peptidase family U32; Region: Peptidase_U32; pfam01136
717962004783	Collagenase; Region: DUF3656; pfam12392
717962004784	Peptidase family U32; Region: Peptidase_U32; cl03113
717962004785	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
717962004786	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
717962004787	active site
717962004788	Ap6A binding site [chemical binding]; other site
717962004789	nudix motif; other site
717962004790	metal binding site [ion binding]; metal-binding site
717962004791	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
717962004792	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
717962004793	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
717962004794	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
717962004795	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717962004796	RNA binding surface [nucleotide binding]; other site
717962004797	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
717962004798	probable active site [active]
717962004799	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
717962004800	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
717962004801	nucleotide binding pocket [chemical binding]; other site
717962004802	K-X-D-G motif; other site
717962004803	catalytic site [active]
717962004804	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
717962004805	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
717962004806	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
717962004807	Dimer interface [polypeptide binding]; other site
717962004808	BRCT sequence motif; other site
717962004809	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
717962004810	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
717962004811	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962004812	catalytic residue [active]
717962004813	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
717962004814	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
717962004815	trimerization site [polypeptide binding]; other site
717962004816	active site
717962004817	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
717962004818	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
717962004819	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
717962004820	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
717962004821	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
717962004822	Phosphoglycerate kinase; Region: PGK; pfam00162
717962004823	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
717962004824	substrate binding site [chemical binding]; other site
717962004825	hinge regions; other site
717962004826	ADP binding site [chemical binding]; other site
717962004827	catalytic site [active]
717962004828	triosephosphate isomerase; Provisional; Region: PRK14567
717962004829	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
717962004830	substrate binding site [chemical binding]; other site
717962004831	dimer interface [polypeptide binding]; other site
717962004832	catalytic triad [active]
717962004833	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
717962004834	phosphoglyceromutase; Provisional; Region: PRK05434
717962004835	Preprotein translocase SecG subunit; Region: SecG; pfam03840
717962004836	ribonuclease R; Region: RNase_R; TIGR02063
717962004837	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
717962004838	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
717962004839	RNB domain; Region: RNB; pfam00773
717962004840	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
717962004841	RNA binding site [nucleotide binding]; other site
717962004842	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
717962004843	SmpB-tmRNA interface; other site
717962004844	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
717962004845	Predicted transcriptional regulators [Transcription]; Region: COG1695
717962004846	Transcriptional regulator PadR-like family; Region: PadR; cl17335
717962004847	XdhC Rossmann domain; Region: XdhC_C; pfam13478
717962004848	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
717962004849	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
717962004850	MPT binding site; other site
717962004851	trimer interface [polypeptide binding]; other site
717962004852	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
717962004853	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962004854	FeS/SAM binding site; other site
717962004855	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
717962004856	DNA polymerase I; Provisional; Region: PRK05755
717962004857	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
717962004858	active site
717962004859	metal binding site 1 [ion binding]; metal-binding site
717962004860	putative 5' ssDNA interaction site; other site
717962004861	metal binding site 3; metal-binding site
717962004862	metal binding site 2 [ion binding]; metal-binding site
717962004863	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
717962004864	putative DNA binding site [nucleotide binding]; other site
717962004865	putative metal binding site [ion binding]; other site
717962004866	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
717962004867	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
717962004868	active site
717962004869	DNA binding site [nucleotide binding]
717962004870	catalytic site [active]
717962004871	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
717962004872	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
717962004873	CoA-binding site [chemical binding]; other site
717962004874	ATP-binding [chemical binding]; other site
717962004875	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
717962004876	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
717962004877	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
717962004878	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
717962004879	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
717962004880	metal binding site [ion binding]; metal-binding site
717962004881	dimer interface [polypeptide binding]; other site
717962004882	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
717962004883	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717962004884	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962004885	motif II; other site
717962004886	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
717962004887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962004888	FeS/SAM binding site; other site
717962004889	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
717962004890	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
717962004891	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
717962004892	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
717962004893	homodimer interface [polypeptide binding]; other site
717962004894	oligonucleotide binding site [chemical binding]; other site
717962004895	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
717962004896	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717962004897	sulfate transport protein; Provisional; Region: cysT; CHL00187
717962004898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962004899	dimer interface [polypeptide binding]; other site
717962004900	conserved gate region; other site
717962004901	putative PBP binding loops; other site
717962004902	ABC-ATPase subunit interface; other site
717962004903	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
717962004904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962004905	dimer interface [polypeptide binding]; other site
717962004906	conserved gate region; other site
717962004907	putative PBP binding loops; other site
717962004908	ABC-ATPase subunit interface; other site
717962004909	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
717962004910	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
717962004911	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
717962004912	HlyD family secretion protein; Region: HlyD_3; pfam13437
717962004913	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
717962004914	Protein of unknown function (DUF464); Region: DUF464; pfam04327
717962004915	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
717962004916	GTPase CgtA; Reviewed; Region: obgE; PRK12297
717962004917	GTP1/OBG; Region: GTP1_OBG; pfam01018
717962004918	Obg GTPase; Region: Obg; cd01898
717962004919	G1 box; other site
717962004920	GTP/Mg2+ binding site [chemical binding]; other site
717962004921	Switch I region; other site
717962004922	G2 box; other site
717962004923	G3 box; other site
717962004924	Switch II region; other site
717962004925	G4 box; other site
717962004926	G5 box; other site
717962004927	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
717962004928	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
717962004929	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
717962004930	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
717962004931	active site
717962004932	(T/H)XGH motif; other site
717962004933	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962004934	Zn2+ binding site [ion binding]; other site
717962004935	Mg2+ binding site [ion binding]; other site
717962004936	Oligomerisation domain; Region: Oligomerisation; pfam02410
717962004937	LexA repressor; Validated; Region: PRK00215
717962004938	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
717962004939	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
717962004940	Catalytic site [active]
717962004941	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717962004942	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
717962004943	Ligand Binding Site [chemical binding]; other site
717962004944	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
717962004945	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962004946	active site
717962004947	Int/Topo IB signature motif; other site
717962004948	DNA binding site [nucleotide binding]
717962004949	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962004950	Zn2+ binding site [ion binding]; other site
717962004951	Mg2+ binding site [ion binding]; other site
717962004952	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962004953	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962004954	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962004955	active site
717962004956	DNA binding site [nucleotide binding]
717962004957	Int/Topo IB signature motif; other site
717962004958	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962004959	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
717962004960	pyrroline-5-carboxylate reductase; Region: PLN02688
717962004961	hypothetical protein; Validated; Region: PRK00110
717962004962	Domain of unknown function DUF21; Region: DUF21; pfam01595
717962004963	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
717962004964	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
717962004965	Transporter associated domain; Region: CorC_HlyC; pfam03471
717962004966	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
717962004967	alanine racemase; Reviewed; Region: alr; PRK00053
717962004968	active site
717962004969	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717962004970	dimer interface [polypeptide binding]; other site
717962004971	substrate binding site [chemical binding]; other site
717962004972	catalytic residues [active]
717962004973	putative carbohydrate kinase; Provisional; Region: PRK10565
717962004974	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
717962004975	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
717962004976	putative substrate binding site [chemical binding]; other site
717962004977	putative ATP binding site [chemical binding]; other site
717962004978	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
717962004979	CoA binding domain; Region: CoA_binding; pfam02629
717962004980	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
717962004981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962004982	Walker A/P-loop; other site
717962004983	ATP binding site [chemical binding]; other site
717962004984	Q-loop/lid; other site
717962004985	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962004986	ABC transporter signature motif; other site
717962004987	Walker B; other site
717962004988	ABC transporter; Region: ABC_tran_2; pfam12848
717962004989	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962004990	pyruvate kinase; Provisional; Region: PRK06354
717962004991	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
717962004992	domain interfaces; other site
717962004993	active site
717962004994	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
717962004995	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717962004996	active site
717962004997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962004998	non-specific DNA binding site [nucleotide binding]; other site
717962004999	salt bridge; other site
717962005000	sequence-specific DNA binding site [nucleotide binding]; other site
717962005001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
717962005002	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
717962005003	Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324
717962005004	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
717962005005	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
717962005006	HIGH motif; other site
717962005007	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
717962005008	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717962005009	active site
717962005010	KMSKS motif; other site
717962005011	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
717962005012	tRNA binding surface [nucleotide binding]; other site
717962005013	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
717962005014	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
717962005015	elongation factor G; Reviewed; Region: PRK12740
717962005016	G1 box; other site
717962005017	putative GEF interaction site [polypeptide binding]; other site
717962005018	GTP/Mg2+ binding site [chemical binding]; other site
717962005019	Switch I region; other site
717962005020	G2 box; other site
717962005021	G3 box; other site
717962005022	Switch II region; other site
717962005023	G4 box; other site
717962005024	G5 box; other site
717962005025	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
717962005026	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
717962005027	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
717962005028	prephenate dehydrogenase; Validated; Region: PRK06545
717962005029	prephenate dehydrogenase; Validated; Region: PRK08507
717962005030	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
717962005031	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717962005032	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717962005033	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
717962005034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962005035	FeS/SAM binding site; other site
717962005036	Predicted membrane protein [Function unknown]; Region: COG1971
717962005037	Domain of unknown function DUF; Region: DUF204; pfam02659
717962005038	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
717962005039	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962005040	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962005041	ABC transporter; Region: ABC_tran_2; pfam12848
717962005042	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962005043	hypothetical protein; Provisional; Region: PRK05590
717962005044	SEC-C motif; Region: SEC-C; pfam02810
717962005045	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717962005046	2-isopropylmalate synthase; Validated; Region: PRK00915
717962005047	LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.  The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417
717962005048	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
717962005049	active site
717962005050	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
717962005051	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
717962005052	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717962005053	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
717962005054	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717962005055	active site
717962005056	NTP binding site [chemical binding]; other site
717962005057	nucleic acid binding site [nucleotide binding]; other site
717962005058	Phage tail protein; Region: Sipho_tail; cl17486
717962005059	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
717962005060	Phage-related protein [Function unknown]; Region: COG5412
717962005061	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
717962005062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962005063	non-specific DNA binding site [nucleotide binding]; other site
717962005064	salt bridge; other site
717962005065	sequence-specific DNA binding site [nucleotide binding]; other site
717962005066	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962005067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962005068	non-specific DNA binding site [nucleotide binding]; other site
717962005069	salt bridge; other site
717962005070	sequence-specific DNA binding site [nucleotide binding]; other site
717962005071	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717962005072	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
717962005073	catalytic residues [active]
717962005074	catalytic nucleophile [active]
717962005075	Presynaptic Site I dimer interface [polypeptide binding]; other site
717962005076	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
717962005077	Synaptic Flat tetramer interface [polypeptide binding]; other site
717962005078	Synaptic Site I dimer interface [polypeptide binding]; other site
717962005079	DNA binding site [nucleotide binding]
717962005080	Recombinase; Region: Recombinase; pfam07508
717962005081	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717962005082	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
717962005083	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
717962005084	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
717962005085	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
717962005086	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
717962005087	dimer interface [polypeptide binding]; other site
717962005088	motif 1; other site
717962005089	active site
717962005090	motif 2; other site
717962005091	motif 3; other site
717962005092	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
717962005093	S-layer homology domain; Region: SLH; pfam00395
717962005094	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
717962005095	Stage II sporulation protein; Region: SpoIID; pfam08486
717962005096	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
717962005097	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
717962005098	putative active site [active]
717962005099	catalytic site [active]
717962005100	putative metal binding site [ion binding]; other site
717962005101	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
717962005102	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
717962005103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962005104	catalytic residue [active]
717962005105	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
717962005106	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717962005107	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
717962005108	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
717962005109	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
717962005110	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962005111	FeS/SAM binding site; other site
717962005112	TRAM domain; Region: TRAM; pfam01938
717962005113	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
717962005114	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
717962005115	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
717962005116	homodimer interface [polypeptide binding]; other site
717962005117	NADP binding site [chemical binding]; other site
717962005118	substrate binding site [chemical binding]; other site
717962005119	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
717962005120	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
717962005121	Potassium binding sites [ion binding]; other site
717962005122	Cesium cation binding sites [ion binding]; other site
717962005123	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
717962005124	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
717962005125	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
717962005126	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
717962005127	Bacitracin resistance protein BacA; Region: BacA; pfam02673
717962005128	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
717962005129	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
717962005130	active site
717962005131	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
717962005132	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
717962005133	active site
717962005134	metal binding site [ion binding]; metal-binding site
717962005135	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
717962005136	Isochorismatase family; Region: Isochorismatase; pfam00857
717962005137	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
717962005138	catalytic triad [active]
717962005139	conserved cis-peptide bond; other site
717962005140	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
717962005141	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
717962005142	N-acetyl-D-glucosamine binding site [chemical binding]; other site
717962005143	catalytic residue [active]
717962005144	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
717962005145	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
717962005146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962005147	FeS/SAM binding site; other site
717962005148	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
717962005149	active site
717962005150	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
717962005151	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
717962005152	Ligand Binding Site [chemical binding]; other site
717962005153	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
717962005154	phosphopentomutase; Provisional; Region: PRK05362
717962005155	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
717962005156	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717962005157	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
717962005158	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962005159	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717962005160	dimerization interface [polypeptide binding]; other site
717962005161	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962005162	dimer interface [polypeptide binding]; other site
717962005163	phosphorylation site [posttranslational modification]
717962005164	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962005165	ATP binding site [chemical binding]; other site
717962005166	Mg2+ binding site [ion binding]; other site
717962005167	G-X-G motif; other site
717962005168	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962005169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962005170	active site
717962005171	phosphorylation site [posttranslational modification]
717962005172	intermolecular recognition site; other site
717962005173	dimerization interface [polypeptide binding]; other site
717962005174	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962005175	DNA binding site [nucleotide binding]
717962005176	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
717962005177	TrkA-N domain; Region: TrkA_N; pfam02254
717962005178	TrkA-C domain; Region: TrkA_C; pfam02080
717962005179	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
717962005180	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
717962005181	substrate binding site [chemical binding]; other site
717962005182	ligand binding site [chemical binding]; other site
717962005183	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
717962005184	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
717962005185	substrate binding site [chemical binding]; other site
717962005186	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
717962005187	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
717962005188	substrate binding site [chemical binding]; other site
717962005189	ligand binding site [chemical binding]; other site
717962005190	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
717962005191	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
717962005192	substrate binding site [chemical binding]; other site
717962005193	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
717962005194	glycyl-tRNA synthetase; Provisional; Region: PRK04173
717962005195	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
717962005196	motif 1; other site
717962005197	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
717962005198	active site
717962005199	motif 2; other site
717962005200	motif 3; other site
717962005201	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
717962005202	anticodon binding site; other site
717962005203	Recombination protein O N terminal; Region: RecO_N; pfam11967
717962005204	DNA repair protein RecO; Region: reco; TIGR00613
717962005205	Recombination protein O C terminal; Region: RecO_C; pfam02565
717962005206	GTPase Era; Reviewed; Region: era; PRK00089
717962005207	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
717962005208	G1 box; other site
717962005209	GTP/Mg2+ binding site [chemical binding]; other site
717962005210	Switch I region; other site
717962005211	G2 box; other site
717962005212	Switch II region; other site
717962005213	G3 box; other site
717962005214	G4 box; other site
717962005215	G5 box; other site
717962005216	KH domain; Region: KH_2; pfam07650
717962005217	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
717962005218	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
717962005219	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
717962005220	Peptidase M16C associated; Region: M16C_assoc; pfam08367
717962005221	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
717962005222	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
717962005223	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
717962005224	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
717962005225	active site
717962005226	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
717962005227	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
717962005228	ring oligomerisation interface [polypeptide binding]; other site
717962005229	ATP/Mg binding site [chemical binding]; other site
717962005230	stacking interactions; other site
717962005231	hinge regions; other site
717962005232	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
717962005233	oligomerisation interface [polypeptide binding]; other site
717962005234	mobile loop; other site
717962005235	roof hairpin; other site
717962005236	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
717962005237	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717962005238	active site
717962005239	HIGH motif; other site
717962005240	nucleotide binding site [chemical binding]; other site
717962005241	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717962005242	active site
717962005243	KMSKS motif; other site
717962005244	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
717962005245	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
717962005246	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
717962005247	homodimer interface [polypeptide binding]; other site
717962005248	substrate-cofactor binding pocket; other site
717962005249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962005250	catalytic residue [active]
717962005251	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962005252	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962005253	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962005254	dimerization interface [polypeptide binding]; other site
717962005255	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
717962005256	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
717962005257	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
717962005258	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
717962005259	active site
717962005260	metal binding site [ion binding]; metal-binding site
717962005261	dimerization interface [polypeptide binding]; other site
717962005262	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
717962005263	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
717962005264	active site
717962005265	HIGH motif; other site
717962005266	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
717962005267	KMSKS motif; other site
717962005268	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
717962005269	tRNA binding surface [nucleotide binding]; other site
717962005270	anticodon binding site; other site
717962005271	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
717962005272	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
717962005273	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
717962005274	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
717962005275	homotrimer interaction site [polypeptide binding]; other site
717962005276	zinc binding site [ion binding]; other site
717962005277	CDP-binding sites; other site
717962005278	Yqey-like protein; Region: YqeY; cl17540
717962005279	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
717962005280	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
717962005281	active site
717962005282	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
717962005283	active site
717962005284	N-terminal domain interface [polypeptide binding]; other site
717962005285	single-stranded DNA-binding protein; Provisional; Region: PRK05813
717962005286	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
717962005287	dimer interface [polypeptide binding]; other site
717962005288	ssDNA binding site [nucleotide binding]; other site
717962005289	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717962005290	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962005291	Radical SAM superfamily; Region: Radical_SAM; pfam04055
717962005292	FeS/SAM binding site; other site
717962005293	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
717962005294	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
717962005295	active site
717962005296	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
717962005297	ATP cone domain; Region: ATP-cone; pfam03477
717962005298	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
717962005299	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
717962005300	Transposase, Mutator family; Region: Transposase_mut; pfam00872
717962005301	MULE transposase domain; Region: MULE; pfam10551
717962005302	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717962005303	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
717962005304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
717962005305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962005306	S-adenosylmethionine binding site [chemical binding]; other site
717962005307	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
717962005308	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
717962005309	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
717962005310	dimer interface [polypeptide binding]; other site
717962005311	ssDNA binding site [nucleotide binding]; other site
717962005312	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717962005313	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717962005314	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717962005315	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
717962005316	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962005317	Zn2+ binding site [ion binding]; other site
717962005318	Mg2+ binding site [ion binding]; other site
717962005319	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
717962005320	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
717962005321	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
717962005322	RNA/DNA hybrid binding site [nucleotide binding]; other site
717962005323	active site
717962005324	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
717962005325	RNA/DNA hybrid binding site [nucleotide binding]; other site
717962005326	active site
717962005327	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
717962005328	AAA domain; Region: AAA_18; pfam13238
717962005329	active site
717962005330	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
717962005331	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
717962005332	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
717962005333	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
717962005334	TMP-binding site; other site
717962005335	ATP-binding site [chemical binding]; other site
717962005336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
717962005337	LemA family; Region: LemA; cl00742
717962005338	RRXRR protein; Region: RRXRR; pfam14239
717962005339	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
717962005340	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
717962005341	ADP-ribose binding site [chemical binding]; other site
717962005342	TraX protein; Region: TraX; pfam05857
717962005343	Predicted transcriptional regulators [Transcription]; Region: COG1695
717962005344	Transcriptional regulator PadR-like family; Region: PadR; cl17335
717962005345	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
717962005346	active site
717962005347	catalytic site [active]
717962005348	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
717962005349	active site
717962005350	catalytic site [active]
717962005351	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
717962005352	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
717962005353	HSP70 interaction site [polypeptide binding]; other site
717962005354	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
717962005355	Probable transposase; Region: OrfB_IS605; pfam01385
717962005356	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
717962005357	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
717962005358	domain interaction interfaces [polypeptide binding]; other site
717962005359	Cna protein B-type domain; Region: Cna_B; pfam05738
717962005360	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
717962005361	domain interaction interfaces [polypeptide binding]; other site
717962005362	Cna protein B-type domain; Region: Cna_B; pfam05738
717962005363	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
717962005364	domain interaction interfaces [polypeptide binding]; other site
717962005365	Cna protein B-type domain; Region: Cna_B; pfam05738
717962005366	Cna protein B-type domain; Region: Cna_B; pfam05738
717962005367	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
717962005368	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
717962005369	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
717962005370	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
717962005371	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
717962005372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962005373	Walker A motif; other site
717962005374	ATP binding site [chemical binding]; other site
717962005375	Walker B motif; other site
717962005376	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
717962005377	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
717962005378	Transglycosylase; Region: Transgly; pfam00912
717962005379	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
717962005380	V-type ATP synthase subunit I; Validated; Region: PRK05771
717962005381	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717962005382	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
717962005383	active site
717962005384	metal binding site [ion binding]; metal-binding site
717962005385	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
717962005386	Transposase IS200 like; Region: Y1_Tnp; pfam01797
717962005387	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
717962005388	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
717962005389	ADP-ribose binding site [chemical binding]; other site
717962005390	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
717962005391	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
717962005392	Transposase IS200 like; Region: Y1_Tnp; pfam01797
717962005393	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
717962005394	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
717962005395	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
717962005396	DNA-sulfur modification-associated; Region: DndB; cl17621
717962005397	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
717962005398	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717962005399	Soluble P-type ATPase [General function prediction only]; Region: COG4087
717962005400	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
717962005401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962005402	dimer interface [polypeptide binding]; other site
717962005403	phosphorylation site [posttranslational modification]
717962005404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962005405	ATP binding site [chemical binding]; other site
717962005406	Mg2+ binding site [ion binding]; other site
717962005407	G-X-G motif; other site
717962005408	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
717962005409	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
717962005410	active site
717962005411	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
717962005412	transmembrane helices; other site
717962005413	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
717962005414	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
717962005415	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962005416	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
717962005417	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717962005418	flavodoxin; Provisional; Region: PRK06242
717962005419	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
717962005420	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
717962005421	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717962005422	hypothetical protein; Validated; Region: PRK00124
717962005423	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
717962005424	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962005425	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962005426	DNA binding site [nucleotide binding]
717962005427	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
717962005428	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717962005429	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
717962005430	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962005431	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962005432	Walker A/P-loop; other site
717962005433	ATP binding site [chemical binding]; other site
717962005434	Q-loop/lid; other site
717962005435	ABC transporter signature motif; other site
717962005436	Walker B; other site
717962005437	D-loop; other site
717962005438	H-loop/switch region; other site
717962005439	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
717962005440	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
717962005441	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962005442	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962005443	dimer interface [polypeptide binding]; other site
717962005444	phosphorylation site [posttranslational modification]
717962005445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962005446	ATP binding site [chemical binding]; other site
717962005447	Mg2+ binding site [ion binding]; other site
717962005448	G-X-G motif; other site
717962005449	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962005450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962005451	active site
717962005452	phosphorylation site [posttranslational modification]
717962005453	intermolecular recognition site; other site
717962005454	dimerization interface [polypeptide binding]; other site
717962005455	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962005456	DNA binding site [nucleotide binding]
717962005457	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
717962005458	non-specific DNA binding site [nucleotide binding]; other site
717962005459	salt bridge; other site
717962005460	sequence-specific DNA binding site [nucleotide binding]; other site
717962005461	YodL-like; Region: YodL; pfam14191
717962005462	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
717962005463	elongation factor Ts; Provisional; Region: tsf; PRK09377
717962005464	UBA/TS-N domain; Region: UBA; pfam00627
717962005465	Elongation factor TS; Region: EF_TS; pfam00889
717962005466	Elongation factor TS; Region: EF_TS; pfam00889
717962005467	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
717962005468	rRNA interaction site [nucleotide binding]; other site
717962005469	S8 interaction site; other site
717962005470	putative laminin-1 binding site; other site
717962005471	transcriptional repressor CodY; Validated; Region: PRK04158
717962005472	CodY GAF-like domain; Region: CodY; pfam06018
717962005473	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
717962005474	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
717962005475	DNA protecting protein DprA; Region: dprA; TIGR00732
717962005476	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
717962005477	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
717962005478	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
717962005479	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
717962005480	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
717962005481	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
717962005482	putative active site [active]
717962005483	dimerization interface [polypeptide binding]; other site
717962005484	putative tRNAtyr binding site [nucleotide binding]; other site
717962005485	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
717962005486	active site
717962005487	catalytic triad [active]
717962005488	oxyanion hole [active]
717962005489	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
717962005490	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
717962005491	Citrate transporter; Region: CitMHS; pfam03600
717962005492	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962005493	putative active site [active]
717962005494	heme pocket [chemical binding]; other site
717962005495	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962005496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962005497	Walker A motif; other site
717962005498	ATP binding site [chemical binding]; other site
717962005499	Walker B motif; other site
717962005500	arginine finger; other site
717962005501	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962005502	sporulation sigma factor SigG; Reviewed; Region: PRK08215
717962005503	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962005504	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
717962005505	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962005506	DNA binding residues [nucleotide binding]
717962005507	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
717962005508	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
717962005509	active site
717962005510	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
717962005511	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
717962005512	ATP cone domain; Region: ATP-cone; pfam03477
717962005513	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
717962005514	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
717962005515	Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045
717962005516	dimer interface [polypeptide binding]; other site
717962005517	Protein of unknown function DUF58; Region: DUF58; pfam01882
717962005518	MoxR-like ATPases [General function prediction only]; Region: COG0714
717962005519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962005520	Walker A motif; other site
717962005521	ATP binding site [chemical binding]; other site
717962005522	Walker B motif; other site
717962005523	arginine finger; other site
717962005524	sporulation sigma factor SigE; Reviewed; Region: PRK08301
717962005525	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962005526	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962005527	DNA binding residues [nucleotide binding]
717962005528	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
717962005529	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
717962005530	hinge; other site
717962005531	active site
717962005532	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
717962005533	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
717962005534	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
717962005535	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
717962005536	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
717962005537	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
717962005538	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
717962005539	Septum formation initiator; Region: DivIC; cl17659
717962005540	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
717962005541	MraW methylase family; Region: Methyltransf_5; pfam01795
717962005542	cell division protein MraZ; Reviewed; Region: PRK00326
717962005543	MraZ protein; Region: MraZ; pfam02381
717962005544	MraZ protein; Region: MraZ; pfam02381
717962005545	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
717962005546	GTP-binding protein YchF; Reviewed; Region: PRK09601
717962005547	YchF GTPase; Region: YchF; cd01900
717962005548	G1 box; other site
717962005549	GTP/Mg2+ binding site [chemical binding]; other site
717962005550	Switch I region; other site
717962005551	G2 box; other site
717962005552	Switch II region; other site
717962005553	G3 box; other site
717962005554	G4 box; other site
717962005555	G5 box; other site
717962005556	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
717962005557	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
717962005558	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
717962005559	motif I; other site
717962005560	active site
717962005561	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
717962005562	metal binding site 2 [ion binding]; metal-binding site
717962005563	putative DNA binding helix; other site
717962005564	metal binding site 1 [ion binding]; metal-binding site
717962005565	dimer interface [polypeptide binding]; other site
717962005566	structural Zn2+ binding site [ion binding]; other site
717962005567	acetylornithine aminotransferase; Provisional; Region: PRK02627
717962005568	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
717962005569	inhibitor-cofactor binding pocket; inhibition site
717962005570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962005571	catalytic residue [active]
717962005572	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
717962005573	feedback inhibition sensing region; other site
717962005574	homohexameric interface [polypeptide binding]; other site
717962005575	nucleotide binding site [chemical binding]; other site
717962005576	N-acetyl-L-glutamate binding site [chemical binding]; other site
717962005577	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
717962005578	heterotetramer interface [polypeptide binding]; other site
717962005579	active site pocket [active]
717962005580	cleavage site
717962005581	putative acetyltransferase; Provisional; Region: PRK03624
717962005582	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962005583	Coenzyme A binding pocket [chemical binding]; other site
717962005584	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
717962005585	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
717962005586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897
717962005587	argininosuccinate synthase; Provisional; Region: PRK13820
717962005588	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
717962005589	ANP binding site [chemical binding]; other site
717962005590	Substrate Binding Site II [chemical binding]; other site
717962005591	Substrate Binding Site I [chemical binding]; other site
717962005592	FtsX-like permease family; Region: FtsX; pfam02687
717962005593	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962005594	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962005595	Walker A/P-loop; other site
717962005596	ATP binding site [chemical binding]; other site
717962005597	Q-loop/lid; other site
717962005598	ABC transporter signature motif; other site
717962005599	Walker B; other site
717962005600	D-loop; other site
717962005601	H-loop/switch region; other site
717962005602	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962005603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962005604	ATP binding site [chemical binding]; other site
717962005605	Mg2+ binding site [ion binding]; other site
717962005606	G-X-G motif; other site
717962005607	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962005608	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962005609	active site
717962005610	phosphorylation site [posttranslational modification]
717962005611	intermolecular recognition site; other site
717962005612	dimerization interface [polypeptide binding]; other site
717962005613	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962005614	DNA binding site [nucleotide binding]
717962005615	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
717962005616	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
717962005617	HflX GTPase family; Region: HflX; cd01878
717962005618	G1 box; other site
717962005619	GTP/Mg2+ binding site [chemical binding]; other site
717962005620	Switch I region; other site
717962005621	G2 box; other site
717962005622	G3 box; other site
717962005623	Switch II region; other site
717962005624	G4 box; other site
717962005625	G5 box; other site
717962005626	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
717962005627	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
717962005628	active site
717962005629	catalytic triad [active]
717962005630	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
717962005631	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717962005632	putative efflux protein, MATE family; Region: matE; TIGR00797
717962005633	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
717962005634	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717962005635	dimerization domain swap beta strand [polypeptide binding]; other site
717962005636	regulatory protein interface [polypeptide binding]; other site
717962005637	active site
717962005638	regulatory phosphorylation site [posttranslational modification]; other site
717962005639	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717962005640	dimerization interface [polypeptide binding]; other site
717962005641	putative DNA binding site [nucleotide binding]; other site
717962005642	putative Zn2+ binding site [ion binding]; other site
717962005643	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
717962005644	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
717962005645	ATP binding site [chemical binding]; other site
717962005646	Mg++ binding site [ion binding]; other site
717962005647	motif III; other site
717962005648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717962005649	nucleotide binding region [chemical binding]; other site
717962005650	ATP-binding site [chemical binding]; other site
717962005651	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
717962005652	RNA binding site [nucleotide binding]; other site
717962005653	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
717962005654	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
717962005655	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
717962005656	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
717962005657	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
717962005658	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962005659	S-adenosylmethionine binding site [chemical binding]; other site
717962005660	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
717962005661	RNAase interaction site [polypeptide binding]; other site
717962005662	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
717962005663	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
717962005664	HSP70 interaction site [polypeptide binding]; other site
717962005665	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
717962005666	active site 1 [active]
717962005667	active site 2 [active]
717962005668	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
717962005669	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
717962005670	catalytic site [active]
717962005671	G-X2-G-X-G-K; other site
717962005672	hypothetical protein; Provisional; Region: PRK04323
717962005673	hypothetical protein; Provisional; Region: PRK11820
717962005674	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
717962005675	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
717962005676	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
717962005677	Domain of unknown function (DUF814); Region: DUF814; pfam05670
717962005678	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
717962005679	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
717962005680	active site
717962005681	substrate binding site [chemical binding]; other site
717962005682	metal binding site [ion binding]; metal-binding site
717962005683	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
717962005684	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
717962005685	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
717962005686	shikimate binding site; other site
717962005687	NAD(P) binding site [chemical binding]; other site
717962005688	elongation factor P; Validated; Region: PRK00529
717962005689	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
717962005690	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
717962005691	RNA binding site [nucleotide binding]; other site
717962005692	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
717962005693	RNA binding site [nucleotide binding]; other site
717962005694	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
717962005695	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962005696	active site
717962005697	motif I; other site
717962005698	motif II; other site
717962005699	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
717962005700	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962005701	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962005702	DNA binding residues [nucleotide binding]
717962005703	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
717962005704	Peptidase family U32; Region: Peptidase_U32; pfam01136
717962005705	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
717962005706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962005707	S-adenosylmethionine binding site [chemical binding]; other site
717962005708	YceG-like family; Region: YceG; pfam02618
717962005709	ferric uptake regulator; Provisional; Region: fur; PRK09462
717962005710	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
717962005711	metal binding site 2 [ion binding]; metal-binding site
717962005712	putative DNA binding helix; other site
717962005713	metal binding site 1 [ion binding]; metal-binding site
717962005714	dimer interface [polypeptide binding]; other site
717962005715	structural Zn2+ binding site [ion binding]; other site
717962005716	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
717962005717	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
717962005718	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
717962005719	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962005720	FeS/SAM binding site; other site
717962005721	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717962005722	regulatory protein interface [polypeptide binding]; other site
717962005723	regulatory phosphorylation site [posttranslational modification]; other site
717962005724	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
717962005725	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
717962005726	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962005727	catalytic residue [active]
717962005728	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
717962005729	RNA methyltransferase, RsmE family; Region: TIGR00046
717962005730	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
717962005731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
717962005732	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
717962005733	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
717962005734	HSP70 interaction site [polypeptide binding]; other site
717962005735	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
717962005736	substrate binding site [polypeptide binding]; other site
717962005737	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
717962005738	Zn binding sites [ion binding]; other site
717962005739	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
717962005740	dimer interface [polypeptide binding]; other site
717962005741	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
717962005742	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
717962005743	nucleotide binding site [chemical binding]; other site
717962005744	NEF interaction site [polypeptide binding]; other site
717962005745	SBD interface [polypeptide binding]; other site
717962005746	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
717962005747	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
717962005748	stage II sporulation protein P; Region: spore_II_P; TIGR02867
717962005749	germination protease; Provisional; Region: PRK12362
717962005750	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
717962005751	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
717962005752	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
717962005753	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
717962005754	Competence protein; Region: Competence; pfam03772
717962005755	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962005756	Sporulation and spore germination; Region: Germane; pfam10646
717962005757	Sporulation and spore germination; Region: Germane; pfam10646
717962005758	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962005759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962005760	active site
717962005761	phosphorylation site [posttranslational modification]
717962005762	intermolecular recognition site; other site
717962005763	dimerization interface [polypeptide binding]; other site
717962005764	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962005765	DNA binding site [nucleotide binding]
717962005766	SLBB domain; Region: SLBB; pfam10531
717962005767	comEA protein; Region: comE; TIGR01259
717962005768	Helix-hairpin-helix motif; Region: HHH; pfam00633
717962005769	Protein of unknown function, DUF606; Region: DUF606; pfam04657
717962005770	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962005771	FeS/SAM binding site; other site
717962005772	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
717962005773	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
717962005774	metal binding site [ion binding]; metal-binding site
717962005775	dimer interface [polypeptide binding]; other site
717962005776	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
717962005777	active site
717962005778	putative catalytic site [active]
717962005779	DNA binding site [nucleotide binding]
717962005780	putative phosphate binding site [ion binding]; other site
717962005781	metal binding site A [ion binding]; metal-binding site
717962005782	AP binding site [nucleotide binding]; other site
717962005783	metal binding site B [ion binding]; metal-binding site
717962005784	Protein of unknown function (DUF554); Region: DUF554; pfam04474
717962005785	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
717962005786	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
717962005787	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717962005788	Na2 binding site [ion binding]; other site
717962005789	putative substrate binding site 1 [chemical binding]; other site
717962005790	Na binding site 1 [ion binding]; other site
717962005791	putative substrate binding site 2 [chemical binding]; other site
717962005792	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
717962005793	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
717962005794	homodimer interface [polypeptide binding]; other site
717962005795	substrate-cofactor binding pocket; other site
717962005796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962005797	catalytic residue [active]
717962005798	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
717962005799	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
717962005800	active site
717962005801	Zn binding site [ion binding]; other site
717962005802	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962005803	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
717962005804	dimer interface [polypeptide binding]; other site
717962005805	active site
717962005806	ADP-ribose binding site [chemical binding]; other site
717962005807	nudix motif; other site
717962005808	metal binding site [ion binding]; metal-binding site
717962005809	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962005810	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962005811	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
717962005812	Walker A/P-loop; other site
717962005813	ATP binding site [chemical binding]; other site
717962005814	Q-loop/lid; other site
717962005815	ABC transporter signature motif; other site
717962005816	Walker B; other site
717962005817	D-loop; other site
717962005818	H-loop/switch region; other site
717962005819	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962005820	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962005821	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962005822	Walker A/P-loop; other site
717962005823	ATP binding site [chemical binding]; other site
717962005824	Q-loop/lid; other site
717962005825	ABC transporter signature motif; other site
717962005826	Walker B; other site
717962005827	D-loop; other site
717962005828	H-loop/switch region; other site
717962005829	MarR family; Region: MarR_2; pfam12802
717962005830	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
717962005831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962005832	Walker A/P-loop; other site
717962005833	ATP binding site [chemical binding]; other site
717962005834	Q-loop/lid; other site
717962005835	ABC transporter signature motif; other site
717962005836	Walker B; other site
717962005837	D-loop; other site
717962005838	H-loop/switch region; other site
717962005839	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962005840	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
717962005841	TM-ABC transporter signature motif; other site
717962005842	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
717962005843	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717962005844	zinc binding site [ion binding]; other site
717962005845	putative ligand binding site [chemical binding]; other site
717962005846	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962005847	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717962005848	Walker A/P-loop; other site
717962005849	ATP binding site [chemical binding]; other site
717962005850	Q-loop/lid; other site
717962005851	ABC transporter signature motif; other site
717962005852	Walker B; other site
717962005853	D-loop; other site
717962005854	H-loop/switch region; other site
717962005855	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717962005856	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962005857	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
717962005858	Walker A/P-loop; other site
717962005859	ATP binding site [chemical binding]; other site
717962005860	Q-loop/lid; other site
717962005861	ABC transporter signature motif; other site
717962005862	Walker B; other site
717962005863	D-loop; other site
717962005864	H-loop/switch region; other site
717962005865	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717962005866	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
717962005867	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717962005868	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717962005869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962005870	dimer interface [polypeptide binding]; other site
717962005871	conserved gate region; other site
717962005872	putative PBP binding loops; other site
717962005873	ABC-ATPase subunit interface; other site
717962005874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962005875	S-adenosylmethionine binding site [chemical binding]; other site
717962005876	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
717962005877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962005878	dimer interface [polypeptide binding]; other site
717962005879	conserved gate region; other site
717962005880	putative PBP binding loops; other site
717962005881	ABC-ATPase subunit interface; other site
717962005882	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962005883	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
717962005884	Walker A/P-loop; other site
717962005885	ATP binding site [chemical binding]; other site
717962005886	Q-loop/lid; other site
717962005887	ABC transporter signature motif; other site
717962005888	Walker B; other site
717962005889	D-loop; other site
717962005890	H-loop/switch region; other site
717962005891	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
717962005892	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717962005893	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962005894	Walker A/P-loop; other site
717962005895	ATP binding site [chemical binding]; other site
717962005896	Q-loop/lid; other site
717962005897	ABC transporter signature motif; other site
717962005898	Walker B; other site
717962005899	D-loop; other site
717962005900	H-loop/switch region; other site
717962005901	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
717962005902	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717962005903	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
717962005904	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
717962005905	Predicted permeases [General function prediction only]; Region: COG0679
717962005906	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
717962005907	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
717962005908	FMN binding site [chemical binding]; other site
717962005909	substrate binding site [chemical binding]; other site
717962005910	putative catalytic residue [active]
717962005911	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
717962005912	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717962005913	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
717962005914	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
717962005915	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
717962005916	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
717962005917	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
717962005918	carboxyltransferase (CT) interaction site; other site
717962005919	biotinylation site [posttranslational modification]; other site
717962005920	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
717962005921	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
717962005922	dimer interface [polypeptide binding]; other site
717962005923	active site
717962005924	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
717962005925	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
717962005926	NAD(P) binding site [chemical binding]; other site
717962005927	homotetramer interface [polypeptide binding]; other site
717962005928	homodimer interface [polypeptide binding]; other site
717962005929	active site
717962005930	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
717962005931	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
717962005932	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
717962005933	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
717962005934	FMN binding site [chemical binding]; other site
717962005935	substrate binding site [chemical binding]; other site
717962005936	putative catalytic residue [active]
717962005937	acyl carrier protein; Provisional; Region: acpP; PRK00982
717962005938	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
717962005939	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
717962005940	dimer interface [polypeptide binding]; other site
717962005941	active site
717962005942	CoA binding pocket [chemical binding]; other site
717962005943	Predicted transcriptional regulators [Transcription]; Region: COG1695
717962005944	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
717962005945	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962005946	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962005947	dimer interface [polypeptide binding]; other site
717962005948	phosphorylation site [posttranslational modification]
717962005949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962005950	ATP binding site [chemical binding]; other site
717962005951	Mg2+ binding site [ion binding]; other site
717962005952	G-X-G motif; other site
717962005953	Response regulator receiver domain; Region: Response_reg; pfam00072
717962005954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962005955	active site
717962005956	phosphorylation site [posttranslational modification]
717962005957	intermolecular recognition site; other site
717962005958	dimerization interface [polypeptide binding]; other site
717962005959	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962005960	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962005961	substrate binding pocket [chemical binding]; other site
717962005962	membrane-bound complex binding site; other site
717962005963	hinge residues; other site
717962005964	dihydroorotase; Validated; Region: pyrC; PRK09357
717962005965	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962005966	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
717962005967	active site
717962005968	Domain of unknown function, E. rectale Gene description (DUF3877); Region: DUF3877; pfam12993
717962005969	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
717962005970	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
717962005971	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
717962005972	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
717962005973	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962005974	DNA-binding site [nucleotide binding]; DNA binding site
717962005975	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
717962005976	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962005977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962005978	homodimer interface [polypeptide binding]; other site
717962005979	catalytic residue [active]
717962005980	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
717962005981	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
717962005982	catalytic loop [active]
717962005983	iron binding site [ion binding]; other site
717962005984	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
717962005985	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
717962005986	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
717962005987	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
717962005988	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
717962005989	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
717962005990	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962005991	guanine deaminase; Region: guan_deamin; TIGR02967
717962005992	active site
717962005993	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
717962005994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
717962005995	catalytic loop [active]
717962005996	iron binding site [ion binding]; other site
717962005997	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
717962005998	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
717962005999	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
717962006000	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962006001	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717962006002	TM-ABC transporter signature motif; other site
717962006003	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962006004	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717962006005	TM-ABC transporter signature motif; other site
717962006006	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
717962006007	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717962006008	Walker A/P-loop; other site
717962006009	ATP binding site [chemical binding]; other site
717962006010	Q-loop/lid; other site
717962006011	ABC transporter signature motif; other site
717962006012	Walker B; other site
717962006013	D-loop; other site
717962006014	H-loop/switch region; other site
717962006015	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717962006016	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
717962006017	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717962006018	putative ligand binding site [chemical binding]; other site
717962006019	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
717962006020	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
717962006021	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
717962006022	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
717962006023	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962006024	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962006025	active site
717962006026	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
717962006027	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
717962006028	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962006029	DNA-binding site [nucleotide binding]; DNA binding site
717962006030	UTRA domain; Region: UTRA; pfam07702
717962006031	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962006032	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717962006033	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
717962006034	Coenzyme A transferase; Region: CoA_trans; smart00882
717962006035	Coenzyme A transferase; Region: CoA_trans; cl17247
717962006036	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
717962006037	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
717962006038	NodB motif; other site
717962006039	active site
717962006040	catalytic site [active]
717962006041	metal binding site [ion binding]; metal-binding site
717962006042	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
717962006043	active site
717962006044	catalytic residues [active]
717962006045	transketolase; Reviewed; Region: PRK05899
717962006046	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
717962006047	TPP-binding site [chemical binding]; other site
717962006048	dimer interface [polypeptide binding]; other site
717962006049	coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994
717962006050	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962006051	FeS/SAM binding site; other site
717962006052	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
717962006053	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
717962006054	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962006055	Zn2+ binding site [ion binding]; other site
717962006056	Mg2+ binding site [ion binding]; other site
717962006057	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717962006058	synthetase active site [active]
717962006059	NTP binding site [chemical binding]; other site
717962006060	metal binding site [ion binding]; metal-binding site
717962006061	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
717962006062	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
717962006063	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962006064	active site
717962006065	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
717962006066	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
717962006067	Protein export membrane protein; Region: SecD_SecF; pfam02355
717962006068	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
717962006069	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
717962006070	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
717962006071	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
717962006072	active site
717962006073	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
717962006074	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
717962006075	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962006076	active site
717962006077	motif I; other site
717962006078	motif II; other site
717962006079	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
717962006080	Preprotein translocase subunit; Region: YajC; pfam02699
717962006081	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
717962006082	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
717962006083	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
717962006084	regulatory protein interface [polypeptide binding]; other site
717962006085	regulatory phosphorylation site [posttranslational modification]; other site
717962006086	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
717962006087	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
717962006088	Tetramer interface [polypeptide binding]; other site
717962006089	active site
717962006090	FMN-binding site [chemical binding]; other site
717962006091	PspC domain; Region: PspC; pfam04024
717962006092	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
717962006093	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717962006094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962006095	motif II; other site
717962006096	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
717962006097	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
717962006098	active site
717962006099	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717962006100	substrate binding site [chemical binding]; other site
717962006101	catalytic residues [active]
717962006102	dimer interface [polypeptide binding]; other site
717962006103	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
717962006104	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
717962006105	C-terminal domain interface [polypeptide binding]; other site
717962006106	sugar binding site [chemical binding]; other site
717962006107	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
717962006108	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
717962006109	homodimer interface [polypeptide binding]; other site
717962006110	substrate-cofactor binding pocket; other site
717962006111	catalytic residue [active]
717962006112	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
717962006113	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
717962006114	folate binding site [chemical binding]; other site
717962006115	NADP+ binding site [chemical binding]; other site
717962006116	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
717962006117	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
717962006118	dimerization interface [polypeptide binding]; other site
717962006119	active site
717962006120	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717962006121	synthetase active site [active]
717962006122	NTP binding site [chemical binding]; other site
717962006123	metal binding site [ion binding]; metal-binding site
717962006124	Thiamine pyrophosphokinase; Region: TPK; cd07995
717962006125	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
717962006126	active site
717962006127	dimerization interface [polypeptide binding]; other site
717962006128	thiamine binding site [chemical binding]; other site
717962006129	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
717962006130	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
717962006131	substrate binding site [chemical binding]; other site
717962006132	hexamer interface [polypeptide binding]; other site
717962006133	metal binding site [ion binding]; metal-binding site
717962006134	GTPase RsgA; Reviewed; Region: PRK00098
717962006135	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
717962006136	RNA binding site [nucleotide binding]; other site
717962006137	homodimer interface [polypeptide binding]; other site
717962006138	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
717962006139	GTPase/Zn-binding domain interface [polypeptide binding]; other site
717962006140	GTP/Mg2+ binding site [chemical binding]; other site
717962006141	G4 box; other site
717962006142	G5 box; other site
717962006143	G1 box; other site
717962006144	Switch I region; other site
717962006145	G2 box; other site
717962006146	G3 box; other site
717962006147	Switch II region; other site
717962006148	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
717962006149	Catalytic domain of Protein Kinases; Region: PKc; cd00180
717962006150	active site
717962006151	ATP binding site [chemical binding]; other site
717962006152	substrate binding site [chemical binding]; other site
717962006153	activation loop (A-loop); other site
717962006154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
717962006155	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
717962006156	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
717962006157	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
717962006158	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
717962006159	active site
717962006160	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
717962006161	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962006162	FeS/SAM binding site; other site
717962006163	16S rRNA methyltransferase B; Provisional; Region: PRK14902
717962006164	NusB family; Region: NusB; pfam01029
717962006165	putative RNA binding site [nucleotide binding]; other site
717962006166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962006167	S-adenosylmethionine binding site [chemical binding]; other site
717962006168	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
717962006169	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
717962006170	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
717962006171	putative active site [active]
717962006172	substrate binding site [chemical binding]; other site
717962006173	putative cosubstrate binding site; other site
717962006174	catalytic site [active]
717962006175	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
717962006176	substrate binding site [chemical binding]; other site
717962006177	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
717962006178	active site
717962006179	catalytic residues [active]
717962006180	metal binding site [ion binding]; metal-binding site
717962006181	primosome assembly protein PriA; Validated; Region: PRK05580
717962006182	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717962006183	ATP binding site [chemical binding]; other site
717962006184	putative Mg++ binding site [ion binding]; other site
717962006185	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
717962006186	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
717962006187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962006188	motif II; other site
717962006189	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
717962006190	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
717962006191	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
717962006192	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
717962006193	L-lactate permease; Region: Lactate_perm; cl00701
717962006194	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
717962006195	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
717962006196	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
717962006197	putative NADH binding site [chemical binding]; other site
717962006198	putative active site [active]
717962006199	nudix motif; other site
717962006200	putative metal binding site [ion binding]; other site
717962006201	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717962006202	synthetase active site [active]
717962006203	NTP binding site [chemical binding]; other site
717962006204	metal binding site [ion binding]; metal-binding site
717962006205	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
717962006206	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
717962006207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962006208	dimer interface [polypeptide binding]; other site
717962006209	conserved gate region; other site
717962006210	ABC-ATPase subunit interface; other site
717962006211	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
717962006212	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
717962006213	Walker A/P-loop; other site
717962006214	ATP binding site [chemical binding]; other site
717962006215	Q-loop/lid; other site
717962006216	ABC transporter signature motif; other site
717962006217	Walker B; other site
717962006218	D-loop; other site
717962006219	H-loop/switch region; other site
717962006220	NIL domain; Region: NIL; pfam09383
717962006221	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
717962006222	nudix motif; other site
717962006223	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
717962006224	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962006225	Flavodoxin domain; Region: Flavodoxin_5; cl17428
717962006226	EamA-like transporter family; Region: EamA; pfam00892
717962006227	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
717962006228	EamA-like transporter family; Region: EamA; pfam00892
717962006229	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962006230	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717962006231	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
717962006232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962006233	Walker A/P-loop; other site
717962006234	ATP binding site [chemical binding]; other site
717962006235	Q-loop/lid; other site
717962006236	ABC transporter signature motif; other site
717962006237	Walker B; other site
717962006238	D-loop; other site
717962006239	H-loop/switch region; other site
717962006240	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
717962006241	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
717962006242	Carbon starvation protein CstA; Region: CstA; pfam02554
717962006243	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
717962006244	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
717962006245	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717962006246	MarR family; Region: MarR_2; pfam12802
717962006247	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
717962006248	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
717962006249	dimer interface [polypeptide binding]; other site
717962006250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962006251	catalytic residue [active]
717962006252	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
717962006253	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
717962006254	endonuclease III; Region: ENDO3c; smart00478
717962006255	minor groove reading motif; other site
717962006256	helix-hairpin-helix signature motif; other site
717962006257	active site
717962006258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962006259	Walker A motif; other site
717962006260	ATP binding site [chemical binding]; other site
717962006261	Walker B motif; other site
717962006262	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
717962006263	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
717962006264	metal ion-dependent adhesion site (MIDAS); other site
717962006265	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
717962006266	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
717962006267	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
717962006268	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
717962006269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962006270	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
717962006271	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962006272	DNA binding residues [nucleotide binding]
717962006273	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
717962006274	ATP cone domain; Region: ATP-cone; pfam03477
717962006275	Class III ribonucleotide reductase; Region: RNR_III; cd01675
717962006276	effector binding site; other site
717962006277	active site
717962006278	Zn binding site [ion binding]; other site
717962006279	glycine loop; other site
717962006280	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
717962006281	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
717962006282	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
717962006283	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962006284	FeS/SAM binding site; other site
717962006285	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
717962006286	trimer interface [polypeptide binding]; other site
717962006287	active site
717962006288	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
717962006289	NAD(P) binding site [chemical binding]; other site
717962006290	catalytic residues [active]
717962006291	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
717962006292	metal binding site [ion binding]; metal-binding site
717962006293	seryl-tRNA synthetase; Provisional; Region: PRK05431
717962006294	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
717962006295	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
717962006296	dimer interface [polypeptide binding]; other site
717962006297	active site
717962006298	motif 1; other site
717962006299	motif 2; other site
717962006300	motif 3; other site
717962006301	Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997
717962006302	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
717962006303	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
717962006304	catalytic residues [active]
717962006305	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
717962006306	phosphate binding site [ion binding]; other site
717962006307	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
717962006308	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
717962006309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962006310	catalytic residue [active]
717962006311	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
717962006312	substrate binding site [chemical binding]; other site
717962006313	active site
717962006314	catalytic residues [active]
717962006315	heterodimer interface [polypeptide binding]; other site
717962006316	ParB-like nuclease domain; Region: ParBc; pfam02195
717962006317	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962006318	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
717962006319	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
717962006320	Magnesium ion binding site [ion binding]; other site
717962006321	ParB-like nuclease domain; Region: ParB; smart00470
717962006322	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
717962006323	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
717962006324	Putative transposase; Region: Y2_Tnp; pfam04986
717962006325	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
717962006326	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962006327	active site
717962006328	DNA binding site [nucleotide binding]
717962006329	Int/Topo IB signature motif; other site
717962006330	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
717962006331	conserved cys residue [active]
717962006332	integron integrase; Region: integrase_gron; TIGR02249
717962006333	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962006334	active site
717962006335	DNA binding site [nucleotide binding]
717962006336	Int/Topo IB signature motif; other site
717962006337	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
717962006338	Putative transposase; Region: Y2_Tnp; pfam04986
717962006339	CpXC protein; Region: CpXC; pfam14353
717962006340	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962006341	non-specific DNA binding site [nucleotide binding]; other site
717962006342	salt bridge; other site
717962006343	sequence-specific DNA binding site [nucleotide binding]; other site
717962006344	DNA polymerase IV; Reviewed; Region: PRK03103
717962006345	Y-family of DNA polymerases; Region: PolY; cl12025
717962006346	active site
717962006347	DNA binding site [nucleotide binding]
717962006348	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
717962006349	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962006350	DNA binding residues [nucleotide binding]
717962006351	Cna protein B-type domain; Region: Cna_B; pfam05738
717962006352	Cna protein B-type domain; Region: Cna_B; pfam05738
717962006353	Cna protein B-type domain; Region: Cna_B; pfam05738
717962006354	Cna protein B-type domain; Region: Cna_B; pfam05738
717962006355	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
717962006356	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717962006357	Walker A motif; other site
717962006358	ATP binding site [chemical binding]; other site
717962006359	Walker B motif; other site
717962006360	Maff2 family; Region: Maff2; pfam12750
717962006361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962006362	salt bridge; other site
717962006363	non-specific DNA binding site [nucleotide binding]; other site
717962006364	sequence-specific DNA binding site [nucleotide binding]; other site
717962006365	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962006366	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962006367	non-specific DNA binding site [nucleotide binding]; other site
717962006368	salt bridge; other site
717962006369	sequence-specific DNA binding site [nucleotide binding]; other site
717962006370	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
717962006371	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
717962006372	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497
717962006373	active site
717962006374	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717962006375	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717962006376	putative catalytic residues [active]
717962006377	catalytic nucleophile [active]
717962006378	Recombinase; Region: Recombinase; pfam07508
717962006379	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717962006380	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717962006381	Maff2 family; Region: Maff2; pfam12750
717962006382	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
717962006383	PrgI family protein; Region: PrgI; pfam12666
717962006384	rRNA processing; Region: rRNA_processing; pfam08524
717962006385	3D domain; Region: 3D; cl01439
717962006386	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717962006387	NlpC/P60 family; Region: NLPC_P60; pfam00877
717962006388	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
717962006389	DNA topoisomerase III; Provisional; Region: PRK07726
717962006390	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
717962006391	active site
717962006392	putative interdomain interaction site [polypeptide binding]; other site
717962006393	putative metal-binding site [ion binding]; other site
717962006394	putative nucleotide binding site [chemical binding]; other site
717962006395	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
717962006396	domain I; other site
717962006397	DNA binding groove [nucleotide binding]
717962006398	phosphate binding site [ion binding]; other site
717962006399	domain II; other site
717962006400	domain III; other site
717962006401	nucleotide binding site [chemical binding]; other site
717962006402	catalytic site [active]
717962006403	domain IV; other site
717962006404	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
717962006405	MPN+ (JAMM) motif; other site
717962006406	Zinc-binding site [ion binding]; other site
717962006407	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
717962006408	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
717962006409	YodL-like; Region: YodL; pfam14191
717962006410	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
717962006411	YodL-like; Region: YodL; pfam14191
717962006412	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717962006413	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
717962006414	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
717962006415	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
717962006416	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717962006417	Walker A/P-loop; other site
717962006418	ATP binding site [chemical binding]; other site
717962006419	Q-loop/lid; other site
717962006420	ABC transporter signature motif; other site
717962006421	Walker B; other site
717962006422	D-loop; other site
717962006423	H-loop/switch region; other site
717962006424	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
717962006425	Walker A/P-loop; other site
717962006426	ATP binding site [chemical binding]; other site
717962006427	Q-loop/lid; other site
717962006428	ABC transporter signature motif; other site
717962006429	Walker B; other site
717962006430	D-loop; other site
717962006431	H-loop/switch region; other site
717962006432	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962006433	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962006434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962006435	Walker A/P-loop; other site
717962006436	ATP binding site [chemical binding]; other site
717962006437	Q-loop/lid; other site
717962006438	ABC transporter signature motif; other site
717962006439	Walker B; other site
717962006440	D-loop; other site
717962006441	H-loop/switch region; other site
717962006442	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962006443	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962006444	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962006445	Walker A/P-loop; other site
717962006446	ATP binding site [chemical binding]; other site
717962006447	Q-loop/lid; other site
717962006448	ABC transporter signature motif; other site
717962006449	Walker B; other site
717962006450	D-loop; other site
717962006451	H-loop/switch region; other site
717962006452	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
717962006453	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
717962006454	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717962006455	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962006456	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962006457	non-specific DNA binding site [nucleotide binding]; other site
717962006458	salt bridge; other site
717962006459	sequence-specific DNA binding site [nucleotide binding]; other site
717962006460	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
717962006461	trimer interface [polypeptide binding]; other site
717962006462	active site
717962006463	Thymidylate synthase complementing protein; Region: Thy1; cl03630
717962006464	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717962006465	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
717962006466	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
717962006467	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
717962006468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962006469	Coenzyme A binding pocket [chemical binding]; other site
717962006470	Divergent AAA domain; Region: AAA_4; pfam04326
717962006471	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
717962006472	multimer interface [polypeptide binding]; other site
717962006473	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
717962006474	Helix-turn-helix domain; Region: HTH_17; pfam12728
717962006475	Helix-turn-helix domain; Region: HTH_17; pfam12728
717962006476	Helix-turn-helix domain; Region: HTH_17; pfam12728
717962006477	Helix-turn-helix domain; Region: HTH_17; pfam12728
717962006478	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962006479	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962006480	active site
717962006481	DNA binding site [nucleotide binding]
717962006482	Int/Topo IB signature motif; other site
717962006483	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
717962006484	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
717962006485	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
717962006486	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962006487	Coenzyme A binding pocket [chemical binding]; other site
717962006488	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
717962006489	TfoX N-terminal domain; Region: TfoX_N; pfam04993
717962006490	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
717962006491	AAA domain; Region: AAA_14; pfam13173
717962006492	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
717962006493	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
717962006494	DNA binding residues [nucleotide binding]
717962006495	dimer interface [polypeptide binding]; other site
717962006496	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
717962006497	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962006498	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
717962006499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
717962006500	Coenzyme A binding pocket [chemical binding]; other site
717962006501	Tubby C 2; Region: Tub_2; cl02043
717962006502	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
717962006503	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
717962006504	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
717962006505	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
717962006506	dimer interface [polypeptide binding]; other site
717962006507	active site
717962006508	metal binding site [ion binding]; metal-binding site
717962006509	glutathione binding site [chemical binding]; other site
717962006510	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
717962006511	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
717962006512	putative trimer interface [polypeptide binding]; other site
717962006513	putative CoA binding site [chemical binding]; other site
717962006514	Rrf2 family protein; Region: rrf2_super; TIGR00738
717962006515	Transcriptional regulator; Region: Rrf2; pfam02082
717962006516	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
717962006517	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
717962006518	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
717962006519	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
717962006520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962006521	dimer interface [polypeptide binding]; other site
717962006522	phosphorylation site [posttranslational modification]
717962006523	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
717962006524	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
717962006525	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
717962006526	TrkA-N domain; Region: TrkA_N; pfam02254
717962006527	TrkA-C domain; Region: TrkA_C; pfam02080
717962006528	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962006529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962006530	active site
717962006531	phosphorylation site [posttranslational modification]
717962006532	intermolecular recognition site; other site
717962006533	dimerization interface [polypeptide binding]; other site
717962006534	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962006535	DNA binding site [nucleotide binding]
717962006536	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
717962006537	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962006538	Zn2+ binding site [ion binding]; other site
717962006539	Mg2+ binding site [ion binding]; other site
717962006540	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962006541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962006542	metal binding site [ion binding]; metal-binding site
717962006543	active site
717962006544	I-site; other site
717962006545	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
717962006546	Protein of unknown function (DUF1284); Region: DUF1284; pfam06935
717962006547	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962006548	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142
717962006549	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
717962006550	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
717962006551	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
717962006552	Acylphosphatase; Region: Acylphosphatase; pfam00708
717962006553	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
717962006554	HypF finger; Region: zf-HYPF; pfam07503
717962006555	HypF finger; Region: zf-HYPF; pfam07503
717962006556	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
717962006557	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
717962006558	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
717962006559	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
717962006560	dimerization interface [polypeptide binding]; other site
717962006561	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
717962006562	ATP binding site [chemical binding]; other site
717962006563	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
717962006564	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717962006565	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
717962006566	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
717962006567	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
717962006568	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
717962006569	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
717962006570	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
717962006571	G1 box; other site
717962006572	GTP/Mg2+ binding site [chemical binding]; other site
717962006573	Switch I region; other site
717962006574	G2 box; other site
717962006575	Switch II region; other site
717962006576	G3 box; other site
717962006577	G4 box; other site
717962006578	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
717962006579	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
717962006580	Rubredoxin; Region: Rubredoxin; pfam00301
717962006581	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
717962006582	iron binding site [ion binding]; other site
717962006583	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
717962006584	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962006585	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717962006586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962006587	PAS fold; Region: PAS; pfam00989
717962006588	putative active site [active]
717962006589	heme pocket [chemical binding]; other site
717962006590	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962006591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962006592	Walker A motif; other site
717962006593	ATP binding site [chemical binding]; other site
717962006594	Walker B motif; other site
717962006595	arginine finger; other site
717962006596	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962006597	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
717962006598	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
717962006599	active site 2 [active]
717962006600	active site 1 [active]
717962006601	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
717962006602	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
717962006603	Walker A/P-loop; other site
717962006604	ATP binding site [chemical binding]; other site
717962006605	Q-loop/lid; other site
717962006606	ABC transporter signature motif; other site
717962006607	Walker B; other site
717962006608	D-loop; other site
717962006609	H-loop/switch region; other site
717962006610	TOBE domain; Region: TOBE_2; pfam08402
717962006611	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
717962006612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962006613	dimer interface [polypeptide binding]; other site
717962006614	conserved gate region; other site
717962006615	putative PBP binding loops; other site
717962006616	ABC-ATPase subunit interface; other site
717962006617	sulfate transport protein; Provisional; Region: cysT; CHL00187
717962006618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962006619	dimer interface [polypeptide binding]; other site
717962006620	conserved gate region; other site
717962006621	putative PBP binding loops; other site
717962006622	ABC-ATPase subunit interface; other site
717962006623	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
717962006624	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717962006625	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717962006626	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
717962006627	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
717962006628	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
717962006629	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
717962006630	active site
717962006631	catalytic motif [active]
717962006632	Zn binding site [ion binding]; other site
717962006633	AAA domain; Region: AAA_21; pfam13304
717962006634	Predicted membrane protein [Function unknown]; Region: COG2364
717962006635	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
717962006636	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
717962006637	catalytic residues [active]
717962006638	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
717962006639	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717962006640	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
717962006641	putative transporter; Provisional; Region: PRK11660
717962006642	Sulfate transporter family; Region: Sulfate_transp; pfam00916
717962006643	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
717962006644	asparagine synthetase AsnA; Provisional; Region: PRK05425
717962006645	motif 1; other site
717962006646	dimer interface [polypeptide binding]; other site
717962006647	active site
717962006648	motif 2; other site
717962006649	motif 3; other site
717962006650	PAS fold; Region: PAS_4; pfam08448
717962006651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962006652	putative active site [active]
717962006653	heme pocket [chemical binding]; other site
717962006654	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962006655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962006656	Walker A motif; other site
717962006657	ATP binding site [chemical binding]; other site
717962006658	Walker B motif; other site
717962006659	arginine finger; other site
717962006660	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962006661	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
717962006662	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
717962006663	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
717962006664	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
717962006665	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
717962006666	Na binding site [ion binding]; other site
717962006667	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
717962006668	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
717962006669	homodimer interface [polypeptide binding]; other site
717962006670	substrate binding pocket [chemical binding]; other site
717962006671	NAD binding site [chemical binding]; other site
717962006672	catalytic residues [active]
717962006673	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
717962006674	P-loop containing region of AAA domain; Region: AAA_29; cl17516
717962006675	AAA domain; Region: AAA_22; pfam13401
717962006676	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
717962006677	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717962006678	substrate binding site [chemical binding]; other site
717962006679	oxyanion hole (OAH) forming residues; other site
717962006680	trimer interface [polypeptide binding]; other site
717962006681	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
717962006682	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
717962006683	CoA-transferase family III; Region: CoA_transf_3; pfam02515
717962006684	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
717962006685	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
717962006686	active site
717962006687	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962006688	PAS domain; Region: PAS_9; pfam13426
717962006689	putative active site [active]
717962006690	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962006691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962006692	Walker A motif; other site
717962006693	ATP binding site [chemical binding]; other site
717962006694	Walker B motif; other site
717962006695	arginine finger; other site
717962006696	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717962006697	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
717962006698	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717962006699	myosin-cross-reactive antigen; Provisional; Region: PRK13977
717962006700	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
717962006701	active site
717962006702	catalytic residues [active]
717962006703	metal binding site [ion binding]; metal-binding site
717962006704	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
717962006705	HSP70 interaction site [polypeptide binding]; other site
717962006706	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
717962006707	substrate binding site [polypeptide binding]; other site
717962006708	dimer interface [polypeptide binding]; other site
717962006709	FeoA domain; Region: FeoA; pfam04023
717962006710	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
717962006711	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
717962006712	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
717962006713	G1 box; other site
717962006714	GTP/Mg2+ binding site [chemical binding]; other site
717962006715	Switch I region; other site
717962006716	G2 box; other site
717962006717	G3 box; other site
717962006718	Switch II region; other site
717962006719	G4 box; other site
717962006720	G5 box; other site
717962006721	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
717962006722	Nucleoside recognition; Region: Gate; pfam07670
717962006723	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
717962006724	Nucleoside recognition; Region: Gate; pfam07670
717962006725	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
717962006726	putative DNA binding helix; other site
717962006727	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
717962006728	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717962006729	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
717962006730	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
717962006731	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717962006732	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
717962006733	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962006734	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962006735	DNA binding residues [nucleotide binding]
717962006736	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962006737	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962006738	Walker A/P-loop; other site
717962006739	ATP binding site [chemical binding]; other site
717962006740	Q-loop/lid; other site
717962006741	ABC transporter signature motif; other site
717962006742	Walker B; other site
717962006743	D-loop; other site
717962006744	H-loop/switch region; other site
717962006745	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717962006746	FtsX-like permease family; Region: FtsX; pfam02687
717962006747	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
717962006748	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
717962006749	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
717962006750	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
717962006751	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717962006752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962006753	dimer interface [polypeptide binding]; other site
717962006754	conserved gate region; other site
717962006755	putative PBP binding loops; other site
717962006756	ABC-ATPase subunit interface; other site
717962006757	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
717962006758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962006759	dimer interface [polypeptide binding]; other site
717962006760	conserved gate region; other site
717962006761	putative PBP binding loops; other site
717962006762	ABC-ATPase subunit interface; other site
717962006763	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717962006764	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962006765	Walker A/P-loop; other site
717962006766	ATP binding site [chemical binding]; other site
717962006767	Q-loop/lid; other site
717962006768	ABC transporter signature motif; other site
717962006769	Walker B; other site
717962006770	D-loop; other site
717962006771	H-loop/switch region; other site
717962006772	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717962006773	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
717962006774	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962006775	Walker A/P-loop; other site
717962006776	ATP binding site [chemical binding]; other site
717962006777	Q-loop/lid; other site
717962006778	ABC transporter signature motif; other site
717962006779	Walker B; other site
717962006780	D-loop; other site
717962006781	H-loop/switch region; other site
717962006782	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717962006783	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
717962006784	putative active site [active]
717962006785	nucleotide binding site [chemical binding]; other site
717962006786	nudix motif; other site
717962006787	putative metal binding site [ion binding]; other site
717962006788	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
717962006789	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
717962006790	NADP binding site [chemical binding]; other site
717962006791	active site
717962006792	putative substrate binding site [chemical binding]; other site
717962006793	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
717962006794	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
717962006795	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962006796	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717962006797	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
717962006798	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
717962006799	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
717962006800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962006801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962006802	dimer interface [polypeptide binding]; other site
717962006803	phosphorylation site [posttranslational modification]
717962006804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962006805	ATP binding site [chemical binding]; other site
717962006806	Mg2+ binding site [ion binding]; other site
717962006807	G-X-G motif; other site
717962006808	Response regulator receiver domain; Region: Response_reg; pfam00072
717962006809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962006810	active site
717962006811	phosphorylation site [posttranslational modification]
717962006812	intermolecular recognition site; other site
717962006813	dimerization interface [polypeptide binding]; other site
717962006814	Response regulator receiver domain; Region: Response_reg; pfam00072
717962006815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962006816	active site
717962006817	phosphorylation site [posttranslational modification]
717962006818	intermolecular recognition site; other site
717962006819	dimerization interface [polypeptide binding]; other site
717962006820	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962006821	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717962006822	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962006823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962006824	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717962006825	dimerization interface [polypeptide binding]; other site
717962006826	Histidine kinase; Region: His_kinase; pfam06580
717962006827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962006828	ATP binding site [chemical binding]; other site
717962006829	Mg2+ binding site [ion binding]; other site
717962006830	G-X-G motif; other site
717962006831	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
717962006832	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
717962006833	putative ligand binding site [chemical binding]; other site
717962006834	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
717962006835	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717962006836	Walker A/P-loop; other site
717962006837	ATP binding site [chemical binding]; other site
717962006838	Q-loop/lid; other site
717962006839	ABC transporter signature motif; other site
717962006840	Walker B; other site
717962006841	D-loop; other site
717962006842	H-loop/switch region; other site
717962006843	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717962006844	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
717962006845	TM-ABC transporter signature motif; other site
717962006846	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962006847	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
717962006848	TM-ABC transporter signature motif; other site
717962006849	L-arabinose isomerase; Provisional; Region: PRK02929
717962006850	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
717962006851	hexamer (dimer of trimers) interface [polypeptide binding]; other site
717962006852	trimer interface [polypeptide binding]; other site
717962006853	substrate binding site [chemical binding]; other site
717962006854	Mn binding site [ion binding]; other site
717962006855	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
717962006856	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
717962006857	putative N- and C-terminal domain interface [polypeptide binding]; other site
717962006858	putative active site [active]
717962006859	MgATP binding site [chemical binding]; other site
717962006860	catalytic site [active]
717962006861	metal binding site [ion binding]; metal-binding site
717962006862	putative carbohydrate binding site [chemical binding]; other site
717962006863	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
717962006864	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
717962006865	intersubunit interface [polypeptide binding]; other site
717962006866	active site
717962006867	Zn2+ binding site [ion binding]; other site
717962006868	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
717962006869	active site
717962006870	intersubunit interactions; other site
717962006871	catalytic residue [active]
717962006872	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
717962006873	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
717962006874	hexamer (dimer of trimers) interface [polypeptide binding]; other site
717962006875	substrate binding site [chemical binding]; other site
717962006876	trimer interface [polypeptide binding]; other site
717962006877	Mn binding site [ion binding]; other site
717962006878	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
717962006879	N- and C-terminal domain interface [polypeptide binding]; other site
717962006880	D-xylulose kinase; Region: XylB; TIGR01312
717962006881	active site
717962006882	MgATP binding site [chemical binding]; other site
717962006883	catalytic site [active]
717962006884	metal binding site [ion binding]; metal-binding site
717962006885	xylulose binding site [chemical binding]; other site
717962006886	homodimer interface [polypeptide binding]; other site
717962006887	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962006888	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962006889	metal binding site [ion binding]; metal-binding site
717962006890	active site
717962006891	I-site; other site
717962006892	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962006893	metal binding site [ion binding]; metal-binding site
717962006894	active site
717962006895	I-site; other site
717962006896	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
717962006897	FeoA domain; Region: FeoA; pfam04023
717962006898	Predicted permeases [General function prediction only]; Region: COG0730
717962006899	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
717962006900	MgtE intracellular N domain; Region: MgtE_N; pfam03448
717962006901	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
717962006902	Divalent cation transporter; Region: MgtE; pfam01769
717962006903	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
717962006904	Uncharacterized conserved protein [Function unknown]; Region: COG2461
717962006905	Family of unknown function (DUF438); Region: DUF438; pfam04282
717962006906	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
717962006907	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
717962006908	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
717962006909	ligand binding site [chemical binding]; other site
717962006910	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
717962006911	non-specific DNA interactions [nucleotide binding]; other site
717962006912	DNA binding site [nucleotide binding]
717962006913	sequence specific DNA binding site [nucleotide binding]; other site
717962006914	putative cAMP binding site [chemical binding]; other site
717962006915	Cupin domain; Region: Cupin_2; pfam07883
717962006916	Class I aldolases; Region: Aldolase_Class_I; cl17187
717962006917	catalytic residue [active]
717962006918	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962006919	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717962006920	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
717962006921	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
717962006922	DNA binding residues [nucleotide binding]
717962006923	dimer interface [polypeptide binding]; other site
717962006924	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
717962006925	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
717962006926	putative dimer interface [polypeptide binding]; other site
717962006927	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
717962006928	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
717962006929	putative dimer interface [polypeptide binding]; other site
717962006930	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
717962006931	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
717962006932	active site
717962006933	FMN binding site [chemical binding]; other site
717962006934	substrate binding site [chemical binding]; other site
717962006935	putative catalytic residue [active]
717962006936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717962006937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717962006938	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962006939	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962006940	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962006941	dimerization interface [polypeptide binding]; other site
717962006942	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
717962006943	classical (c) SDRs; Region: SDR_c; cd05233
717962006944	NAD(P) binding site [chemical binding]; other site
717962006945	active site
717962006946	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
717962006947	classical (c) SDRs; Region: SDR_c; cd05233
717962006948	NAD(P) binding site [chemical binding]; other site
717962006949	active site
717962006950	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
717962006951	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
717962006952	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
717962006953	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
717962006954	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
717962006955	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962006956	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962006957	metal binding site [ion binding]; metal-binding site
717962006958	active site
717962006959	I-site; other site
717962006960	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962006961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962006962	dimer interface [polypeptide binding]; other site
717962006963	phosphorylation site [posttranslational modification]
717962006964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962006965	ATP binding site [chemical binding]; other site
717962006966	Mg2+ binding site [ion binding]; other site
717962006967	G-X-G motif; other site
717962006968	Response regulator receiver domain; Region: Response_reg; pfam00072
717962006969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962006970	active site
717962006971	phosphorylation site [posttranslational modification]
717962006972	intermolecular recognition site; other site
717962006973	dimerization interface [polypeptide binding]; other site
717962006974	Membrane transport protein; Region: Mem_trans; cl09117
717962006975	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
717962006976	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717962006977	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
717962006978	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
717962006979	Clp amino terminal domain; Region: Clp_N; pfam02861
717962006980	Clp amino terminal domain; Region: Clp_N; pfam02861
717962006981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962006982	Walker A motif; other site
717962006983	ATP binding site [chemical binding]; other site
717962006984	Walker B motif; other site
717962006985	arginine finger; other site
717962006986	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962006987	Walker A motif; other site
717962006988	ATP binding site [chemical binding]; other site
717962006989	Walker B motif; other site
717962006990	arginine finger; other site
717962006991	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
717962006992	DHHW protein; Region: DHHW; pfam14286
717962006993	DHHW protein; Region: DHHW; pfam14286
717962006994	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
717962006995	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
717962006996	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
717962006997	active site
717962006998	catalytic triad [active]
717962006999	oxyanion hole [active]
717962007000	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962007001	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717962007002	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962007003	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962007004	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962007005	dimerization interface [polypeptide binding]; other site
717962007006	Chromate transporter; Region: Chromate_transp; pfam02417
717962007007	Chromate transporter; Region: Chromate_transp; pfam02417
717962007008	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
717962007009	active site
717962007010	substrate binding site [chemical binding]; other site
717962007011	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
717962007012	FMN binding site [chemical binding]; other site
717962007013	putative catalytic residues [active]
717962007014	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717962007015	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
717962007016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962007017	dimer interface [polypeptide binding]; other site
717962007018	conserved gate region; other site
717962007019	putative PBP binding loops; other site
717962007020	ABC-ATPase subunit interface; other site
717962007021	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717962007022	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962007023	Walker A/P-loop; other site
717962007024	ATP binding site [chemical binding]; other site
717962007025	Q-loop/lid; other site
717962007026	ABC transporter signature motif; other site
717962007027	Walker B; other site
717962007028	D-loop; other site
717962007029	H-loop/switch region; other site
717962007030	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717962007031	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
717962007032	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962007033	Walker A/P-loop; other site
717962007034	ATP binding site [chemical binding]; other site
717962007035	Q-loop/lid; other site
717962007036	ABC transporter signature motif; other site
717962007037	Walker B; other site
717962007038	D-loop; other site
717962007039	H-loop/switch region; other site
717962007040	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717962007041	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
717962007042	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
717962007043	peptide binding site [polypeptide binding]; other site
717962007044	Divergent AAA domain; Region: AAA_4; pfam04326
717962007045	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
717962007046	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
717962007047	nudix motif; other site
717962007048	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
717962007049	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
717962007050	HIGH motif; other site
717962007051	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
717962007052	active site
717962007053	KMSKS motif; other site
717962007054	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
717962007055	tRNA binding surface [nucleotide binding]; other site
717962007056	anticodon binding site; other site
717962007057	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
717962007058	homodimer interface [polypeptide binding]; other site
717962007059	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
717962007060	active site pocket [active]
717962007061	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
717962007062	DNA binding site [nucleotide binding]
717962007063	Bacterial transcriptional activator domain; Region: BTAD; smart01043
717962007064	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
717962007065	binding surface
717962007066	TPR motif; other site
717962007067	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
717962007068	PA14 domain; Region: PA14; cl08459
717962007069	Cna protein B-type domain; Region: Cna_B; pfam05738
717962007070	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
717962007071	metal ion-dependent adhesion site (MIDAS); other site
717962007072	Cna protein B-type domain; Region: Cna_B; pfam05738
717962007073	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
717962007074	Cna protein B-type domain; Region: Cna_B; pfam05738
717962007075	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
717962007076	active site
717962007077	catalytic site [active]
717962007078	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
717962007079	active site
717962007080	catalytic site [active]
717962007081	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
717962007082	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
717962007083	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
717962007084	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
717962007085	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
717962007086	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
717962007087	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
717962007088	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717962007089	Walker A motif; other site
717962007090	ATP binding site [chemical binding]; other site
717962007091	Walker B motif; other site
717962007092	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
717962007093	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
717962007094	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
717962007095	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
717962007096	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
717962007097	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
717962007098	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
717962007099	putative dimer interface [polypeptide binding]; other site
717962007100	putative anticodon binding site; other site
717962007101	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
717962007102	homodimer interface [polypeptide binding]; other site
717962007103	motif 1; other site
717962007104	motif 2; other site
717962007105	active site
717962007106	motif 3; other site
717962007107	Predicted permeases [General function prediction only]; Region: COG0679
717962007108	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717962007109	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
717962007110	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717962007111	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962007112	Walker A/P-loop; other site
717962007113	ATP binding site [chemical binding]; other site
717962007114	Q-loop/lid; other site
717962007115	ABC transporter signature motif; other site
717962007116	Walker B; other site
717962007117	D-loop; other site
717962007118	H-loop/switch region; other site
717962007119	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717962007120	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
717962007121	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717962007122	Walker A/P-loop; other site
717962007123	ATP binding site [chemical binding]; other site
717962007124	Q-loop/lid; other site
717962007125	ABC transporter signature motif; other site
717962007126	Walker B; other site
717962007127	D-loop; other site
717962007128	H-loop/switch region; other site
717962007129	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717962007130	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717962007131	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
717962007132	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717962007133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962007134	dimer interface [polypeptide binding]; other site
717962007135	conserved gate region; other site
717962007136	putative PBP binding loops; other site
717962007137	ABC-ATPase subunit interface; other site
717962007138	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
717962007139	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717962007140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717962007141	dimer interface [polypeptide binding]; other site
717962007142	conserved gate region; other site
717962007143	putative PBP binding loops; other site
717962007144	ABC-ATPase subunit interface; other site
717962007145	Predicted oxidoreductase [General function prediction only]; Region: COG3573
717962007146	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
717962007147	active site
717962007148	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
717962007149	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188
717962007150	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
717962007151	CAP-like domain; other site
717962007152	active site
717962007153	primary dimer interface [polypeptide binding]; other site
717962007154	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717962007155	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717962007156	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
717962007157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007158	Mg2+ binding site [ion binding]; other site
717962007159	G-X-G motif; other site
717962007160	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
717962007161	anchoring element; other site
717962007162	dimer interface [polypeptide binding]; other site
717962007163	ATP binding site [chemical binding]; other site
717962007164	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
717962007165	active site
717962007166	putative metal-binding site [ion binding]; other site
717962007167	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
717962007168	6-phosphofructokinase; Provisional; Region: PRK03202
717962007169	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
717962007170	active site
717962007171	ADP/pyrophosphate binding site [chemical binding]; other site
717962007172	dimerization interface [polypeptide binding]; other site
717962007173	allosteric effector site; other site
717962007174	fructose-1,6-bisphosphate binding site; other site
717962007175	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
717962007176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962007177	Walker A motif; other site
717962007178	ATP binding site [chemical binding]; other site
717962007179	Walker B motif; other site
717962007180	arginine finger; other site
717962007181	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
717962007182	hypothetical protein; Validated; Region: PRK00153
717962007183	recombination protein RecR; Reviewed; Region: recR; PRK00076
717962007184	RecR protein; Region: RecR; pfam02132
717962007185	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
717962007186	putative active site [active]
717962007187	putative metal-binding site [ion binding]; other site
717962007188	tetramer interface [polypeptide binding]; other site
717962007189	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
717962007190	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
717962007191	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717962007192	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
717962007193	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
717962007194	active site
717962007195	Zn binding site [ion binding]; other site
717962007196	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962007197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962007198	LysR substrate binding domain; Region: LysR_substrate; pfam03466
717962007199	dimerization interface [polypeptide binding]; other site
717962007200	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
717962007201	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717962007202	Walker A/P-loop; other site
717962007203	ATP binding site [chemical binding]; other site
717962007204	Q-loop/lid; other site
717962007205	ABC transporter signature motif; other site
717962007206	Walker B; other site
717962007207	D-loop; other site
717962007208	H-loop/switch region; other site
717962007209	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
717962007210	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
717962007211	nucleotide binding site [chemical binding]; other site
717962007212	NEF interaction site [polypeptide binding]; other site
717962007213	SBD interface [polypeptide binding]; other site
717962007214	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962007215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007216	active site
717962007217	phosphorylation site [posttranslational modification]
717962007218	intermolecular recognition site; other site
717962007219	dimerization interface [polypeptide binding]; other site
717962007220	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962007221	DNA binding site [nucleotide binding]
717962007222	Uncharacterized conserved protein [Function unknown]; Region: COG1359
717962007223	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
717962007224	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
717962007225	putative deacylase active site [active]
717962007226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
717962007227	hypothetical protein; Provisional; Region: PRK13663
717962007228	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717962007229	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
717962007230	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
717962007231	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
717962007232	active site
717962007233	dimer interface [polypeptide binding]; other site
717962007234	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
717962007235	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
717962007236	FAD binding pocket [chemical binding]; other site
717962007237	FAD binding motif [chemical binding]; other site
717962007238	phosphate binding motif [ion binding]; other site
717962007239	beta-alpha-beta structure motif; other site
717962007240	NAD binding pocket [chemical binding]; other site
717962007241	Iron coordination center [ion binding]; other site
717962007242	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
717962007243	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
717962007244	heterodimer interface [polypeptide binding]; other site
717962007245	active site
717962007246	FMN binding site [chemical binding]; other site
717962007247	homodimer interface [polypeptide binding]; other site
717962007248	substrate binding site [chemical binding]; other site
717962007249	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
717962007250	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
717962007251	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717962007252	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
717962007253	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
717962007254	intersubunit interface [polypeptide binding]; other site
717962007255	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
717962007256	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
717962007257	Walker A/P-loop; other site
717962007258	ATP binding site [chemical binding]; other site
717962007259	Q-loop/lid; other site
717962007260	ABC transporter signature motif; other site
717962007261	Walker B; other site
717962007262	D-loop; other site
717962007263	H-loop/switch region; other site
717962007264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
717962007265	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
717962007266	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
717962007267	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962007268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962007269	Walker A/P-loop; other site
717962007270	ATP binding site [chemical binding]; other site
717962007271	Q-loop/lid; other site
717962007272	ABC transporter signature motif; other site
717962007273	Walker B; other site
717962007274	D-loop; other site
717962007275	H-loop/switch region; other site
717962007276	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962007277	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962007278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962007279	Walker A/P-loop; other site
717962007280	ATP binding site [chemical binding]; other site
717962007281	Q-loop/lid; other site
717962007282	ABC transporter signature motif; other site
717962007283	Walker B; other site
717962007284	D-loop; other site
717962007285	H-loop/switch region; other site
717962007286	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
717962007287	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
717962007288	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
717962007289	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
717962007290	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962007291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962007292	homodimer interface [polypeptide binding]; other site
717962007293	catalytic residue [active]
717962007294	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962007295	active site
717962007296	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
717962007297	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
717962007298	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
717962007299	ATP-grasp domain; Region: ATP-grasp; pfam02222
717962007300	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
717962007301	amidophosphoribosyltransferase; Provisional; Region: PRK05793
717962007302	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
717962007303	active site
717962007304	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962007305	active site
717962007306	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
717962007307	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
717962007308	dimerization interface [polypeptide binding]; other site
717962007309	putative ATP binding site [chemical binding]; other site
717962007310	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
717962007311	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
717962007312	active site
717962007313	substrate binding site [chemical binding]; other site
717962007314	cosubstrate binding site; other site
717962007315	catalytic site [active]
717962007316	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
717962007317	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
717962007318	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
717962007319	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
717962007320	Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605
717962007321	shikimate kinase; Reviewed; Region: aroK; PRK00131
717962007322	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
717962007323	ADP binding site [chemical binding]; other site
717962007324	magnesium binding site [ion binding]; other site
717962007325	putative shikimate binding site; other site
717962007326	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
717962007327	endonuclease III; Region: ENDO3c; smart00478
717962007328	minor groove reading motif; other site
717962007329	helix-hairpin-helix signature motif; other site
717962007330	substrate binding pocket [chemical binding]; other site
717962007331	active site
717962007332	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
717962007333	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
717962007334	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
717962007335	DNA binding site [nucleotide binding]
717962007336	active site
717962007337	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
717962007338	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962007339	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962007340	DNA binding residues [nucleotide binding]
717962007341	major facilitator superfamily transporter; Provisional; Region: PRK05122
717962007342	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962007343	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
717962007344	Walker A/P-loop; other site
717962007345	ATP binding site [chemical binding]; other site
717962007346	Q-loop/lid; other site
717962007347	ABC transporter signature motif; other site
717962007348	Walker B; other site
717962007349	D-loop; other site
717962007350	H-loop/switch region; other site
717962007351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
717962007352	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
717962007353	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
717962007354	active site
717962007355	catalytic residue [active]
717962007356	dimer interface [polypeptide binding]; other site
717962007357	Transcriptional regulators [Transcription]; Region: MarR; COG1846
717962007358	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
717962007359	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962007360	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962007361	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962007362	Walker A/P-loop; other site
717962007363	ATP binding site [chemical binding]; other site
717962007364	Q-loop/lid; other site
717962007365	ABC transporter signature motif; other site
717962007366	Walker B; other site
717962007367	D-loop; other site
717962007368	H-loop/switch region; other site
717962007369	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962007370	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962007371	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
717962007372	Walker A/P-loop; other site
717962007373	ATP binding site [chemical binding]; other site
717962007374	Q-loop/lid; other site
717962007375	ABC transporter signature motif; other site
717962007376	Walker B; other site
717962007377	D-loop; other site
717962007378	H-loop/switch region; other site
717962007379	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717962007380	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
717962007381	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
717962007382	hypothetical protein; Validated; Region: PRK00124
717962007383	ornithine carbamoyltransferase; Validated; Region: PRK02102
717962007384	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
717962007385	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
717962007386	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717962007387	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
717962007388	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
717962007389	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
717962007390	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
717962007391	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
717962007392	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
717962007393	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
717962007394	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717962007395	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
717962007396	active site
717962007397	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
717962007398	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
717962007399	zinc binding site [ion binding]; other site
717962007400	putative ligand binding site [chemical binding]; other site
717962007401	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717962007402	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
717962007403	TM-ABC transporter signature motif; other site
717962007404	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
717962007405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962007406	Walker A/P-loop; other site
717962007407	ATP binding site [chemical binding]; other site
717962007408	Q-loop/lid; other site
717962007409	ABC transporter signature motif; other site
717962007410	Walker B; other site
717962007411	D-loop; other site
717962007412	H-loop/switch region; other site
717962007413	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
717962007414	homotrimer interaction site [polypeptide binding]; other site
717962007415	putative active site [active]
717962007416	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
717962007417	EDD domain protein, DegV family; Region: DegV; TIGR00762
717962007418	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
717962007419	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
717962007420	ThiS interaction site; other site
717962007421	putative active site [active]
717962007422	tetramer interface [polypeptide binding]; other site
717962007423	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
717962007424	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717962007425	FeS/SAM binding site; other site
717962007426	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
717962007427	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
717962007428	thiamine phosphate binding site [chemical binding]; other site
717962007429	active site
717962007430	pyrophosphate binding site [ion binding]; other site
717962007431	DNA polymerase IV; Reviewed; Region: PRK03103
717962007432	Y-family of DNA polymerases; Region: PolY; cl12025
717962007433	active site
717962007434	DNA binding site [nucleotide binding]
717962007435	YolD-like protein; Region: YolD; pfam08863
717962007436	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
717962007437	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717962007438	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
717962007439	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
717962007440	active site
717962007441	HIGH motif; other site
717962007442	dimer interface [polypeptide binding]; other site
717962007443	KMSKS motif; other site
717962007444	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962007445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962007446	non-specific DNA binding site [nucleotide binding]; other site
717962007447	salt bridge; other site
717962007448	sequence-specific DNA binding site [nucleotide binding]; other site
717962007449	serine O-acetyltransferase; Region: cysE; TIGR01172
717962007450	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
717962007451	trimer interface [polypeptide binding]; other site
717962007452	active site
717962007453	substrate binding site [chemical binding]; other site
717962007454	CoA binding site [chemical binding]; other site
717962007455	Rrf2 family protein; Region: rrf2_super; TIGR00738
717962007456	Transcriptional regulator; Region: Rrf2; pfam02082
717962007457	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717962007458	active site
717962007459	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
717962007460	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
717962007461	substrate binding site [chemical binding]; other site
717962007462	nucleotide binding site [chemical binding]; other site
717962007463	ribosome recycling factor; Reviewed; Region: frr; PRK00083
717962007464	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
717962007465	hinge region; other site
717962007466	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
717962007467	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
717962007468	catalytic residue [active]
717962007469	putative FPP diphosphate  binding site; other site
717962007470	putative FPP binding hydrophobic cleft; other site
717962007471	dimer interface [polypeptide binding]; other site
717962007472	putative IPP diphosphate binding site; other site
717962007473	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
717962007474	GcpE protein; Region: GcpE; pfam04551
717962007475	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
717962007476	ribosome maturation protein RimP; Reviewed; Region: PRK00092
717962007477	Sm and related proteins; Region: Sm_like; cl00259
717962007478	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
717962007479	putative oligomer interface [polypeptide binding]; other site
717962007480	putative RNA binding site [nucleotide binding]; other site
717962007481	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
717962007482	NusA N-terminal domain; Region: NusA_N; pfam08529
717962007483	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
717962007484	RNA binding site [nucleotide binding]; other site
717962007485	homodimer interface [polypeptide binding]; other site
717962007486	NusA-like KH domain; Region: KH_5; pfam13184
717962007487	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
717962007488	G-X-X-G motif; other site
717962007489	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
717962007490	putative RNA binding cleft [nucleotide binding]; other site
717962007491	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
717962007492	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
717962007493	DHH family; Region: DHH; pfam01368
717962007494	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
717962007495	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
717962007496	RNA binding site [nucleotide binding]; other site
717962007497	active site
717962007498	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
717962007499	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
717962007500	active site
717962007501	Riboflavin kinase; Region: Flavokinase; pfam01687
717962007502	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
717962007503	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
717962007504	Maf-like protein; Reviewed; Region: PRK00078
717962007505	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
717962007506	active site
717962007507	dimer interface [polypeptide binding]; other site
717962007508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
717962007509	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
717962007510	23S rRNA interface [nucleotide binding]; other site
717962007511	L3 interface [polypeptide binding]; other site
717962007512	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
717962007513	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
717962007514	Divergent AAA domain; Region: AAA_4; pfam04326
717962007515	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
717962007516	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717962007517	Helix-turn-helix domain; Region: HTH_17; pfam12728
717962007518	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962007519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007520	active site
717962007521	phosphorylation site [posttranslational modification]
717962007522	intermolecular recognition site; other site
717962007523	dimerization interface [polypeptide binding]; other site
717962007524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962007525	DNA binding site [nucleotide binding]
717962007526	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
717962007527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007528	dimer interface [polypeptide binding]; other site
717962007529	phosphorylation site [posttranslational modification]
717962007530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007531	ATP binding site [chemical binding]; other site
717962007532	Mg2+ binding site [ion binding]; other site
717962007533	G-X-G motif; other site
717962007534	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962007535	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
717962007536	Walker A/P-loop; other site
717962007537	ATP binding site [chemical binding]; other site
717962007538	Q-loop/lid; other site
717962007539	ABC transporter signature motif; other site
717962007540	Walker B; other site
717962007541	D-loop; other site
717962007542	H-loop/switch region; other site
717962007543	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
717962007544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007546	dimer interface [polypeptide binding]; other site
717962007547	phosphorylation site [posttranslational modification]
717962007548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007549	ATP binding site [chemical binding]; other site
717962007550	Mg2+ binding site [ion binding]; other site
717962007551	G-X-G motif; other site
717962007552	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962007553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007554	active site
717962007555	phosphorylation site [posttranslational modification]
717962007556	intermolecular recognition site; other site
717962007557	dimerization interface [polypeptide binding]; other site
717962007558	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962007559	DNA binding site [nucleotide binding]
717962007560	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
717962007561	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
717962007562	Walker A/P-loop; other site
717962007563	ATP binding site [chemical binding]; other site
717962007564	Q-loop/lid; other site
717962007565	ABC transporter signature motif; other site
717962007566	Walker B; other site
717962007567	D-loop; other site
717962007568	H-loop/switch region; other site
717962007569	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962007570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
717962007571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
717962007572	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962007573	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962007574	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717962007575	Walker A/P-loop; other site
717962007576	ATP binding site [chemical binding]; other site
717962007577	Q-loop/lid; other site
717962007578	ABC transporter signature motif; other site
717962007579	Walker B; other site
717962007580	D-loop; other site
717962007581	H-loop/switch region; other site
717962007582	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717962007583	FtsX-like permease family; Region: FtsX; pfam02687
717962007584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007586	ATP binding site [chemical binding]; other site
717962007587	Mg2+ binding site [ion binding]; other site
717962007588	G-X-G motif; other site
717962007589	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
717962007590	AAA ATPase domain; Region: AAA_16; pfam13191
717962007591	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
717962007592	Protein of unknown function (DUF3848); Region: DUF3848; pfam12959
717962007593	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962007594	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962007595	non-specific DNA binding site [nucleotide binding]; other site
717962007596	salt bridge; other site
717962007597	sequence-specific DNA binding site [nucleotide binding]; other site
717962007598	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962007599	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962007600	non-specific DNA binding site [nucleotide binding]; other site
717962007601	salt bridge; other site
717962007602	sequence-specific DNA binding site [nucleotide binding]; other site
717962007603	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
717962007604	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962007605	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
717962007606	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962007607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962007608	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717962007609	Walker A/P-loop; other site
717962007610	ATP binding site [chemical binding]; other site
717962007611	Q-loop/lid; other site
717962007612	ABC transporter signature motif; other site
717962007613	Walker B; other site
717962007614	D-loop; other site
717962007615	H-loop/switch region; other site
717962007616	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
717962007617	AAA domain; Region: AAA_14; pfam13173
717962007618	Protein of unknown function (DUF3848); Region: DUF3848; pfam12959
717962007619	bifunctional dihydrofolate reductase-thymidylate synthase; Provisional; Region: PTZ00164
717962007620	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717962007621	CAAX protease self-immunity; Region: Abi; pfam02517
717962007622	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962007623	non-specific DNA binding site [nucleotide binding]; other site
717962007624	salt bridge; other site
717962007625	sequence-specific DNA binding site [nucleotide binding]; other site
717962007626	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
717962007627	non-specific DNA binding site [nucleotide binding]; other site
717962007628	salt bridge; other site
717962007629	sequence-specific DNA binding site [nucleotide binding]; other site
717962007630	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
717962007631	SnoaL-like domain; Region: SnoaL_3; pfam13474
717962007632	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
717962007633	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007634	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007635	dimer interface [polypeptide binding]; other site
717962007636	phosphorylation site [posttranslational modification]
717962007637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007638	ATP binding site [chemical binding]; other site
717962007639	Mg2+ binding site [ion binding]; other site
717962007640	G-X-G motif; other site
717962007641	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717962007642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007643	active site
717962007644	phosphorylation site [posttranslational modification]
717962007645	intermolecular recognition site; other site
717962007646	dimerization interface [polypeptide binding]; other site
717962007647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
717962007648	active site
717962007649	dimerization interface [polypeptide binding]; other site
717962007650	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
717962007651	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
717962007652	catalytic residues [active]
717962007653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007654	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962007655	active site
717962007656	phosphorylation site [posttranslational modification]
717962007657	intermolecular recognition site; other site
717962007658	dimerization interface [polypeptide binding]; other site
717962007659	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962007660	DNA binding site [nucleotide binding]
717962007661	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007662	HAMP domain; Region: HAMP; pfam00672
717962007663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007664	dimer interface [polypeptide binding]; other site
717962007665	phosphorylation site [posttranslational modification]
717962007666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007667	ATP binding site [chemical binding]; other site
717962007668	Mg2+ binding site [ion binding]; other site
717962007669	G-X-G motif; other site
717962007670	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
717962007671	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
717962007672	active site
717962007673	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
717962007674	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
717962007675	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
717962007676	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
717962007677	NAD binding site [chemical binding]; other site
717962007678	ligand binding site [chemical binding]; other site
717962007679	catalytic site [active]
717962007680	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717962007681	Na2 binding site [ion binding]; other site
717962007682	putative substrate binding site 1 [chemical binding]; other site
717962007683	Na binding site 1 [ion binding]; other site
717962007684	putative substrate binding site 2 [chemical binding]; other site
717962007685	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
717962007686	substrate binding site [chemical binding]; other site
717962007687	multimerization interface [polypeptide binding]; other site
717962007688	ATP binding site [chemical binding]; other site
717962007689	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
717962007690	thiamine phosphate binding site [chemical binding]; other site
717962007691	active site
717962007692	pyrophosphate binding site [ion binding]; other site
717962007693	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
717962007694	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
717962007695	active site
717962007696	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
717962007697	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
717962007698	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
717962007699	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
717962007700	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
717962007701	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
717962007702	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
717962007703	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
717962007704	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
717962007705	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
717962007706	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
717962007707	dimer interface [polypeptide binding]; other site
717962007708	active site
717962007709	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
717962007710	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
717962007711	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
717962007712	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
717962007713	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
717962007714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
717962007715	PAS domain; Region: PAS_9; pfam13426
717962007716	putative active site [active]
717962007717	heme pocket [chemical binding]; other site
717962007718	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717962007719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962007720	Walker B motif; other site
717962007721	arginine finger; other site
717962007722	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
717962007723	FMN binding site [chemical binding]; other site
717962007724	dimer interface [polypeptide binding]; other site
717962007725	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717962007726	dimerization interface [polypeptide binding]; other site
717962007727	putative DNA binding site [nucleotide binding]; other site
717962007728	putative Zn2+ binding site [ion binding]; other site
717962007729	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
717962007730	Predicted integral membrane protein [Function unknown]; Region: COG5658
717962007731	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
717962007732	Peptidase family C69; Region: Peptidase_C69; pfam03577
717962007733	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
717962007734	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
717962007735	NAD(P) binding site [chemical binding]; other site
717962007736	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
717962007737	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
717962007738	ABC-ATPase subunit  interface; other site
717962007739	dimer interface [polypeptide binding]; other site
717962007740	putative PBP binding regions; other site
717962007741	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
717962007742	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
717962007743	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
717962007744	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
717962007745	intersubunit interface [polypeptide binding]; other site
717962007746	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
717962007747	metal binding site 2 [ion binding]; metal-binding site
717962007748	putative DNA binding helix; other site
717962007749	metal binding site 1 [ion binding]; metal-binding site
717962007750	dimer interface [polypeptide binding]; other site
717962007751	structural Zn2+ binding site [ion binding]; other site
717962007752	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962007753	DNA-binding site [nucleotide binding]; DNA binding site
717962007754	Predicted membrane protein [General function prediction only]; Region: COG4194
717962007755	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717962007756	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007758	dimer interface [polypeptide binding]; other site
717962007759	phosphorylation site [posttranslational modification]
717962007760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007761	ATP binding site [chemical binding]; other site
717962007762	Mg2+ binding site [ion binding]; other site
717962007763	G-X-G motif; other site
717962007764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007765	Response regulator receiver domain; Region: Response_reg; pfam00072
717962007766	active site
717962007767	phosphorylation site [posttranslational modification]
717962007768	intermolecular recognition site; other site
717962007769	dimerization interface [polypeptide binding]; other site
717962007770	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
717962007771	GMP synthase; Reviewed; Region: guaA; PRK00074
717962007772	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
717962007773	AMP/PPi binding site [chemical binding]; other site
717962007774	candidate oxyanion hole; other site
717962007775	catalytic triad [active]
717962007776	potential glutamine specificity residues [chemical binding]; other site
717962007777	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
717962007778	ATP Binding subdomain [chemical binding]; other site
717962007779	Ligand Binding sites [chemical binding]; other site
717962007780	Dimerization subdomain; other site
717962007781	Domain of unknown function (DUF955); Region: DUF955; cl01076
717962007782	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962007783	non-specific DNA binding site [nucleotide binding]; other site
717962007784	salt bridge; other site
717962007785	sequence-specific DNA binding site [nucleotide binding]; other site
717962007786	Helix-turn-helix domain; Region: HTH_17; cl17695
717962007787	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
717962007788	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
717962007789	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
717962007790	Int/Topo IB signature motif; other site
717962007791	AAA domain; Region: AAA_25; pfam13481
717962007792	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717962007793	Walker A motif; other site
717962007794	ATP binding site [chemical binding]; other site
717962007795	Walker B motif; other site
717962007796	AAA domain; Region: AAA_25; pfam13481
717962007797	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
717962007798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962007799	Walker B; other site
717962007800	D-loop; other site
717962007801	H-loop/switch region; other site
717962007802	KilA-N domain; Region: KilA-N; pfam04383
717962007803	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717962007804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007805	active site
717962007806	phosphorylation site [posttranslational modification]
717962007807	intermolecular recognition site; other site
717962007808	dimerization interface [polypeptide binding]; other site
717962007809	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717962007810	DNA binding site [nucleotide binding]
717962007811	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962007812	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
717962007813	Walker A/P-loop; other site
717962007814	ATP binding site [chemical binding]; other site
717962007815	Q-loop/lid; other site
717962007816	ABC transporter signature motif; other site
717962007817	Walker B; other site
717962007818	D-loop; other site
717962007819	H-loop/switch region; other site
717962007820	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962007821	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007822	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007823	dimer interface [polypeptide binding]; other site
717962007824	phosphorylation site [posttranslational modification]
717962007825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007826	ATP binding site [chemical binding]; other site
717962007827	Mg2+ binding site [ion binding]; other site
717962007828	G-X-G motif; other site
717962007829	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
717962007830	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717962007831	putative active site [active]
717962007832	putative NTP binding site [chemical binding]; other site
717962007833	putative nucleic acid binding site [nucleotide binding]; other site
717962007834	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
717962007835	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
717962007836	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
717962007837	Transposase; Region: HTH_Tnp_1; pfam01527
717962007838	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
717962007839	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
717962007840	SdpI/YhfL protein family; Region: SdpI; pfam13630
717962007841	integrase; Provisional; Region: int; PHA02601
717962007842	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717962007843	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
717962007844	Int/Topo IB signature motif; other site
717962007845	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962007846	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962007847	non-specific DNA binding site [nucleotide binding]; other site
717962007848	salt bridge; other site
717962007849	sequence-specific DNA binding site [nucleotide binding]; other site
717962007850	Helix-turn-helix domain; Region: HTH_17; cl17695
717962007851	MobA/MobL family; Region: MobA_MobL; pfam03389
717962007852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007854	dimer interface [polypeptide binding]; other site
717962007855	phosphorylation site [posttranslational modification]
717962007856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007857	ATP binding site [chemical binding]; other site
717962007858	Mg2+ binding site [ion binding]; other site
717962007859	G-X-G motif; other site
717962007860	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962007861	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
717962007862	Walker A/P-loop; other site
717962007863	ATP binding site [chemical binding]; other site
717962007864	Q-loop/lid; other site
717962007865	ABC transporter signature motif; other site
717962007866	Walker B; other site
717962007867	D-loop; other site
717962007868	H-loop/switch region; other site
717962007869	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717962007870	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
717962007871	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717962007872	putative active site [active]
717962007873	PAS fold; Region: PAS_3; pfam08447
717962007874	heme pocket [chemical binding]; other site
717962007875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007877	dimer interface [polypeptide binding]; other site
717962007878	phosphorylation site [posttranslational modification]
717962007879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007880	ATP binding site [chemical binding]; other site
717962007881	Mg2+ binding site [ion binding]; other site
717962007882	G-X-G motif; other site
717962007883	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717962007884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007885	active site
717962007886	phosphorylation site [posttranslational modification]
717962007887	intermolecular recognition site; other site
717962007888	dimerization interface [polypeptide binding]; other site
717962007889	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717962007890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007891	active site
717962007892	phosphorylation site [posttranslational modification]
717962007893	intermolecular recognition site; other site
717962007894	dimerization interface [polypeptide binding]; other site
717962007895	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
717962007896	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717962007897	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717962007898	metal binding site [ion binding]; metal-binding site
717962007899	active site
717962007900	I-site; other site
717962007901	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962007902	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962007903	substrate binding pocket [chemical binding]; other site
717962007904	membrane-bound complex binding site; other site
717962007905	hinge residues; other site
717962007906	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962007907	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962007908	substrate binding pocket [chemical binding]; other site
717962007909	membrane-bound complex binding site; other site
717962007910	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007911	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007912	dimer interface [polypeptide binding]; other site
717962007913	phosphorylation site [posttranslational modification]
717962007914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007915	ATP binding site [chemical binding]; other site
717962007916	Mg2+ binding site [ion binding]; other site
717962007917	G-X-G motif; other site
717962007918	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717962007919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007920	active site
717962007921	phosphorylation site [posttranslational modification]
717962007922	intermolecular recognition site; other site
717962007923	dimerization interface [polypeptide binding]; other site
717962007924	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962007925	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
717962007926	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
717962007927	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717962007928	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962007929	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717962007930	putative DNA binding site [nucleotide binding]; other site
717962007931	putative Zn2+ binding site [ion binding]; other site
717962007932	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007933	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007934	dimer interface [polypeptide binding]; other site
717962007935	phosphorylation site [posttranslational modification]
717962007936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007937	ATP binding site [chemical binding]; other site
717962007938	Mg2+ binding site [ion binding]; other site
717962007939	G-X-G motif; other site
717962007940	Response regulator receiver domain; Region: Response_reg; pfam00072
717962007941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007942	active site
717962007943	phosphorylation site [posttranslational modification]
717962007944	intermolecular recognition site; other site
717962007945	dimerization interface [polypeptide binding]; other site
717962007946	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
717962007947	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
717962007948	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
717962007949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007950	dimer interface [polypeptide binding]; other site
717962007951	phosphorylation site [posttranslational modification]
717962007952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007953	ATP binding site [chemical binding]; other site
717962007954	Mg2+ binding site [ion binding]; other site
717962007955	G-X-G motif; other site
717962007956	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717962007957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007958	active site
717962007959	phosphorylation site [posttranslational modification]
717962007960	intermolecular recognition site; other site
717962007961	dimerization interface [polypeptide binding]; other site
717962007962	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962007963	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962007964	substrate binding pocket [chemical binding]; other site
717962007965	membrane-bound complex binding site; other site
717962007966	hinge residues; other site
717962007967	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962007968	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717962007969	substrate binding pocket [chemical binding]; other site
717962007970	membrane-bound complex binding site; other site
717962007971	hinge residues; other site
717962007972	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717962007973	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007974	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962007975	dimer interface [polypeptide binding]; other site
717962007976	phosphorylation site [posttranslational modification]
717962007977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962007978	ATP binding site [chemical binding]; other site
717962007979	Mg2+ binding site [ion binding]; other site
717962007980	G-X-G motif; other site
717962007981	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717962007982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007983	active site
717962007984	phosphorylation site [posttranslational modification]
717962007985	intermolecular recognition site; other site
717962007986	dimerization interface [polypeptide binding]; other site
717962007987	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
717962007988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962007989	active site
717962007990	phosphorylation site [posttranslational modification]
717962007991	intermolecular recognition site; other site
717962007992	dimerization interface [polypeptide binding]; other site
717962007993	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717962007994	Zn2+ binding site [ion binding]; other site
717962007995	Mg2+ binding site [ion binding]; other site
717962007996	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
717962007997	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
717962007998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717962007999	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717962008000	dimer interface [polypeptide binding]; other site
717962008001	phosphorylation site [posttranslational modification]
717962008002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717962008003	ATP binding site [chemical binding]; other site
717962008004	Mg2+ binding site [ion binding]; other site
717962008005	G-X-G motif; other site
717962008006	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717962008007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962008008	active site
717962008009	phosphorylation site [posttranslational modification]
717962008010	intermolecular recognition site; other site
717962008011	dimerization interface [polypeptide binding]; other site
717962008012	Response regulator receiver domain; Region: Response_reg; pfam00072
717962008013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717962008014	active site
717962008015	phosphorylation site [posttranslational modification]
717962008016	intermolecular recognition site; other site
717962008017	dimerization interface [polypeptide binding]; other site
717962008018	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
717962008019	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962008020	Coenzyme A binding pocket [chemical binding]; other site
717962008021	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
717962008022	GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519
717962008023	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
717962008024	ATP Binding subdomain [chemical binding]; other site
717962008025	Ligand Binding sites [chemical binding]; other site
717962008026	Dimerization subdomain; other site
717962008027	Divergent AAA domain; Region: AAA_4; pfam04326
717962008028	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
717962008029	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
717962008030	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
717962008031	active site
717962008032	metal binding site [ion binding]; metal-binding site
717962008033	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
717962008034	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
717962008035	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
717962008036	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
717962008037	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
717962008038	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
717962008039	NAD(P) binding site [chemical binding]; other site
717962008040	catalytic residues [active]
717962008041	aspartate aminotransferase; Provisional; Region: PRK06836
717962008042	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962008043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962008044	homodimer interface [polypeptide binding]; other site
717962008045	catalytic residue [active]
717962008046	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
717962008047	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717962008048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962008049	homodimer interface [polypeptide binding]; other site
717962008050	catalytic residue [active]
717962008051	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
717962008052	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
717962008053	DEAD_2; Region: DEAD_2; pfam06733
717962008054	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
717962008055	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
717962008056	dimer interface [polypeptide binding]; other site
717962008057	[2Fe-2S] cluster binding site [ion binding]; other site
717962008058	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
717962008059	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
717962008060	4Fe-4S binding domain; Region: Fer4; pfam00037
717962008061	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
717962008062	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
717962008063	metal binding site 2 [ion binding]; metal-binding site
717962008064	putative DNA binding helix; other site
717962008065	metal binding site 1 [ion binding]; metal-binding site
717962008066	dimer interface [polypeptide binding]; other site
717962008067	structural Zn2+ binding site [ion binding]; other site
717962008068	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
717962008069	Rubredoxin; Region: Rubredoxin; pfam00301
717962008070	iron binding site [ion binding]; other site
717962008071	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
717962008072	Rubrerythrin [Energy production and conversion]; Region: COG1592
717962008073	diiron binding motif [ion binding]; other site
717962008074	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
717962008075	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717962008076	hypothetical protein; Validated; Region: PRK08116
717962008077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962008078	Walker A motif; other site
717962008079	ATP binding site [chemical binding]; other site
717962008080	Walker B motif; other site
717962008081	Helix-turn-helix domain; Region: HTH_16; pfam12645
717962008082	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717962008083	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
717962008084	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
717962008085	Predicted transcriptional regulators [Transcription]; Region: COG1695
717962008086	Transcriptional regulator PadR-like family; Region: PadR; cl17335
717962008087	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
717962008088	Homoserine O-succinyltransferase; Region: HTS; pfam04204
717962008089	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
717962008090	proposed active site lysine [active]
717962008091	conserved cys residue [active]
717962008092	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717962008093	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
717962008094	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
717962008095	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
717962008096	putative metal binding site [ion binding]; other site
717962008097	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717962008098	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717962008099	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
717962008100	Walker A/P-loop; other site
717962008101	ATP binding site [chemical binding]; other site
717962008102	Q-loop/lid; other site
717962008103	ABC transporter signature motif; other site
717962008104	Walker B; other site
717962008105	D-loop; other site
717962008106	H-loop/switch region; other site
717962008107	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962008108	Coenzyme A binding pocket [chemical binding]; other site
717962008109	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717962008110	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717962008111	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
717962008112	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
717962008113	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
717962008114	Predicted transcriptional regulators [Transcription]; Region: COG1695
717962008115	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
717962008116	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
717962008117	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
717962008118	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
717962008119	oligomeric interface; other site
717962008120	putative active site [active]
717962008121	homodimer interface [polypeptide binding]; other site
717962008122	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
717962008123	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
717962008124	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
717962008125	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
717962008126	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
717962008127	catalytic site [active]
717962008128	subunit interface [polypeptide binding]; other site
717962008129	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
717962008130	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717962008131	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
717962008132	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
717962008133	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717962008134	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717962008135	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
717962008136	IMP binding site; other site
717962008137	dimer interface [polypeptide binding]; other site
717962008138	interdomain contacts; other site
717962008139	partial ornithine binding site; other site
717962008140	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
717962008141	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
717962008142	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
717962008143	BioY family; Region: BioY; pfam02632
717962008144	FeoA domain; Region: FeoA; pfam04023
717962008145	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
717962008146	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
717962008147	G1 box; other site
717962008148	GTP/Mg2+ binding site [chemical binding]; other site
717962008149	Switch I region; other site
717962008150	G2 box; other site
717962008151	G3 box; other site
717962008152	Switch II region; other site
717962008153	G4 box; other site
717962008154	G5 box; other site
717962008155	Nucleoside recognition; Region: Gate; pfam07670
717962008156	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
717962008157	Nucleoside recognition; Region: Gate; pfam07670
717962008158	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
717962008159	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
717962008160	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
717962008161	putative ATP binding site [chemical binding]; other site
717962008162	putative substrate interface [chemical binding]; other site
717962008163	Uncharacterized conserved protein [Function unknown]; Region: COG1624
717962008164	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
717962008165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
717962008166	YbbR-like protein; Region: YbbR; pfam07949
717962008167	YbbR-like protein; Region: YbbR; pfam07949
717962008168	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717962008169	dimerization domain swap beta strand [polypeptide binding]; other site
717962008170	regulatory protein interface [polypeptide binding]; other site
717962008171	active site
717962008172	regulatory phosphorylation site [posttranslational modification]; other site
717962008173	2-isopropylmalate synthase; Validated; Region: PRK03739
717962008174	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
717962008175	active site
717962008176	catalytic residues [active]
717962008177	metal binding site [ion binding]; metal-binding site
717962008178	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
717962008179	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
717962008180	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962008181	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962008182	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962008183	Bacterial SH3 domain homologues; Region: SH3b; smart00287
717962008184	Bacterial SH3 domain; Region: SH3_3; pfam08239
717962008185	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717962008186	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962008187	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
717962008188	DNA binding residues [nucleotide binding]
717962008189	Transcriptional regulator [Transcription]; Region: LytR; COG1316
717962008190	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
717962008191	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
717962008192	protein binding site [polypeptide binding]; other site
717962008193	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
717962008194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962008195	Walker A motif; other site
717962008196	ATP binding site [chemical binding]; other site
717962008197	Walker B motif; other site
717962008198	arginine finger; other site
717962008199	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
717962008200	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
717962008201	active site
717962008202	catalytic triad [active]
717962008203	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
717962008204	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
717962008205	Double zinc ribbon; Region: DZR; pfam12773
717962008206	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
717962008207	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
717962008208	NodB motif; other site
717962008209	active site
717962008210	catalytic site [active]
717962008211	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
717962008212	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
717962008213	G1 box; other site
717962008214	putative GEF interaction site [polypeptide binding]; other site
717962008215	GTP/Mg2+ binding site [chemical binding]; other site
717962008216	Switch I region; other site
717962008217	G2 box; other site
717962008218	G3 box; other site
717962008219	Switch II region; other site
717962008220	G4 box; other site
717962008221	G5 box; other site
717962008222	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
717962008223	EDD domain protein, DegV family; Region: DegV; TIGR00762
717962008224	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
717962008225	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
717962008226	putative active site [active]
717962008227	stage V sporulation protein T; Region: spore_V_T; TIGR02851
717962008228	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
717962008229	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
717962008230	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
717962008231	FMN binding site [chemical binding]; other site
717962008232	active site
717962008233	catalytic residues [active]
717962008234	substrate binding site [chemical binding]; other site
717962008235	YheO-like PAS domain; Region: PAS_6; pfam08348
717962008236	HTH domain; Region: HTH_22; pfam13309
717962008237	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
717962008238	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
717962008239	active site
717962008240	dimer interface [polypeptide binding]; other site
717962008241	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
717962008242	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
717962008243	active site
717962008244	FMN binding site [chemical binding]; other site
717962008245	substrate binding site [chemical binding]; other site
717962008246	3Fe-4S cluster binding site [ion binding]; other site
717962008247	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
717962008248	domain interface; other site
717962008249	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
717962008250	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717962008251	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
717962008252	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717962008253	Coenzyme A binding pocket [chemical binding]; other site
717962008254	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
717962008255	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
717962008256	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
717962008257	FMN binding site [chemical binding]; other site
717962008258	dimer interface [polypeptide binding]; other site
717962008259	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
717962008260	peptidase T; Region: peptidase-T; TIGR01882
717962008261	metal binding site [ion binding]; metal-binding site
717962008262	dimer interface [polypeptide binding]; other site
717962008263	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
717962008264	DNA-binding site [nucleotide binding]; DNA binding site
717962008265	RNA-binding motif; other site
717962008266	HEAT repeats; Region: HEAT_2; pfam13646
717962008267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962008268	S-adenosylmethionine binding site [chemical binding]; other site
717962008269	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
717962008270	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
717962008271	DNA binding residues [nucleotide binding]
717962008272	glutamyl-tRNA reductase; Provisional; Region: PRK13940
717962008273	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
717962008274	tRNA; other site
717962008275	putative tRNA binding site [nucleotide binding]; other site
717962008276	putative NADP binding site [chemical binding]; other site
717962008277	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
717962008278	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
717962008279	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
717962008280	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
717962008281	domain interfaces; other site
717962008282	active site
717962008283	Predicted methyltransferases [General function prediction only]; Region: COG0313
717962008284	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
717962008285	active site
717962008286	SAM binding site [chemical binding]; other site
717962008287	homodimer interface [polypeptide binding]; other site
717962008288	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
717962008289	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
717962008290	active site
717962008291	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
717962008292	dimer interface [polypeptide binding]; other site
717962008293	active site
717962008294	Schiff base residues; other site
717962008295	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
717962008296	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
717962008297	inhibitor-cofactor binding pocket; inhibition site
717962008298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962008299	catalytic residue [active]
717962008300	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
717962008301	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
717962008302	putative acyl-acceptor binding pocket; other site
717962008303	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
717962008304	Cupin domain; Region: Cupin_2; cl17218
717962008305	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
717962008306	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962008307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717962008308	Trp repressor protein; Region: Trp_repressor; cl17266
717962008309	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
717962008310	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
717962008311	Cupin domain; Region: Cupin_2; cl17218
717962008312	Predicted membrane protein [Function unknown]; Region: COG2364
717962008313	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717962008314	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
717962008315	NMT1-like family; Region: NMT1_2; pfam13379
717962008316	substrate binding pocket [chemical binding]; other site
717962008317	membrane-bound complex binding site; other site
717962008318	hinge residues; other site
717962008319	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
717962008320	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
717962008321	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
717962008322	Uncharacterized conserved protein [Function unknown]; Region: COG2966
717962008323	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
717962008324	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
717962008325	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962008326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962008327	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962008328	dimerization interface [polypeptide binding]; other site
717962008329	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
717962008330	putative active site [active]
717962008331	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717962008332	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
717962008333	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
717962008334	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
717962008335	Catalytic site [active]
717962008336	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
717962008337	RNA binding site [nucleotide binding]; other site
717962008338	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
717962008339	RNA binding site [nucleotide binding]; other site
717962008340	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
717962008341	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
717962008342	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717962008343	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717962008344	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
717962008345	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
717962008346	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962008347	S-adenosylmethionine binding site [chemical binding]; other site
717962008348	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
717962008349	active site
717962008350	catalytic residues [active]
717962008351	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
717962008352	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
717962008353	G1 box; other site
717962008354	putative GEF interaction site [polypeptide binding]; other site
717962008355	GTP/Mg2+ binding site [chemical binding]; other site
717962008356	Switch I region; other site
717962008357	G2 box; other site
717962008358	G3 box; other site
717962008359	Switch II region; other site
717962008360	G4 box; other site
717962008361	G5 box; other site
717962008362	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
717962008363	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
717962008364	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
717962008365	YacP-like NYN domain; Region: NYN_YacP; pfam05991
717962008366	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
717962008367	putative efflux protein, MATE family; Region: matE; TIGR00797
717962008368	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
717962008369	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
717962008370	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717962008371	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
717962008372	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
717962008373	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717962008374	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717962008375	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
717962008376	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717962008377	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
717962008378	synthetase active site [active]
717962008379	NTP binding site [chemical binding]; other site
717962008380	metal binding site [ion binding]; metal-binding site
717962008381	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
717962008382	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
717962008383	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
717962008384	Walker A motif; other site
717962008385	ATP binding site [chemical binding]; other site
717962008386	Walker B motif; other site
717962008387	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
717962008388	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
717962008389	Walker A motif; other site
717962008390	ATP binding site [chemical binding]; other site
717962008391	Walker B motif; other site
717962008392	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
717962008393	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
717962008394	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
717962008395	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
717962008396	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
717962008397	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
717962008398	Competence protein A; Region: Competence_A; pfam11104
717962008399	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
717962008400	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
717962008401	APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148
717962008402	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
717962008403	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
717962008404	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
717962008405	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
717962008406	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
717962008407	23S rRNA binding site [nucleotide binding]; other site
717962008408	L21 binding site [polypeptide binding]; other site
717962008409	L13 binding site [polypeptide binding]; other site
717962008410	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
717962008411	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
717962008412	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
717962008413	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
717962008414	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
717962008415	trimer interface [polypeptide binding]; other site
717962008416	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
717962008417	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
717962008418	active site
717962008419	HIGH motif; other site
717962008420	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
717962008421	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
717962008422	active site
717962008423	KMSKS motif; other site
717962008424	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
717962008425	Part of AAA domain; Region: AAA_19; pfam13245
717962008426	Family description; Region: UvrD_C_2; pfam13538
717962008427	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
717962008428	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962008429	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962008430	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962008431	dimerization interface [polypeptide binding]; other site
717962008432	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
717962008433	4Fe-4S binding domain; Region: Fer4; cl02805
717962008434	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
717962008435	4Fe-4S binding domain; Region: Fer4; cl02805
717962008436	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
717962008437	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
717962008438	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
717962008439	dimerization interface [polypeptide binding]; other site
717962008440	ATP binding site [chemical binding]; other site
717962008441	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
717962008442	dimerization interface [polypeptide binding]; other site
717962008443	ATP binding site [chemical binding]; other site
717962008444	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
717962008445	putative active site [active]
717962008446	catalytic triad [active]
717962008447	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional; Region: PRK14489
717962008448	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
717962008449	GTP binding site; other site
717962008450	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
717962008451	Walker A motif; other site
717962008452	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
717962008453	DNA binding residues [nucleotide binding]
717962008454	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
717962008455	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
717962008456	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
717962008457	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
717962008458	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
717962008459	NodB motif; other site
717962008460	active site
717962008461	catalytic site [active]
717962008462	Zn binding site [ion binding]; other site
717962008463	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
717962008464	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717962008465	Walker A/P-loop; other site
717962008466	ATP binding site [chemical binding]; other site
717962008467	Q-loop/lid; other site
717962008468	ABC transporter signature motif; other site
717962008469	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962008470	ABC transporter; Region: ABC_tran_2; pfam12848
717962008471	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962008472	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
717962008473	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962008474	ABC transporter; Region: ABC_tran_2; pfam12848
717962008475	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717962008476	TraX protein; Region: TraX; pfam05857
717962008477	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
717962008478	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
717962008479	S-ribosylhomocysteinase; Provisional; Region: PRK02260
717962008480	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
717962008481	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
717962008482	structural tetrad; other site
717962008483	Predicted transcriptional regulators [Transcription]; Region: COG1695
717962008484	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
717962008485	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
717962008486	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
717962008487	G1 box; other site
717962008488	putative GEF interaction site [polypeptide binding]; other site
717962008489	GTP/Mg2+ binding site [chemical binding]; other site
717962008490	Switch I region; other site
717962008491	G2 box; other site
717962008492	G3 box; other site
717962008493	Switch II region; other site
717962008494	G4 box; other site
717962008495	G5 box; other site
717962008496	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
717962008497	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
717962008498	single-stranded DNA-binding protein; Provisional; Region: PRK05813
717962008499	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
717962008500	dimer interface [polypeptide binding]; other site
717962008501	ssDNA binding site [nucleotide binding]; other site
717962008502	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717962008503	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
717962008504	dihydrodipicolinate synthase; Region: dapA; TIGR00674
717962008505	dimer interface [polypeptide binding]; other site
717962008506	active site
717962008507	catalytic residue [active]
717962008508	dihydrodipicolinate reductase; Provisional; Region: PRK00048
717962008509	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
717962008510	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
717962008511	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
717962008512	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
717962008513	NAD synthetase; Reviewed; Region: nadE; PRK02628
717962008514	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
717962008515	multimer interface [polypeptide binding]; other site
717962008516	active site
717962008517	catalytic triad [active]
717962008518	protein interface 1 [polypeptide binding]; other site
717962008519	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
717962008520	homodimer interface [polypeptide binding]; other site
717962008521	NAD binding pocket [chemical binding]; other site
717962008522	ATP binding pocket [chemical binding]; other site
717962008523	Mg binding site [ion binding]; other site
717962008524	active-site loop [active]
717962008525	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
717962008526	Part of AAA domain; Region: AAA_19; pfam13245
717962008527	Family description; Region: UvrD_C_2; pfam13538
717962008528	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
717962008529	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
717962008530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
717962008531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717962008532	S-adenosylmethionine binding site [chemical binding]; other site
717962008533	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
717962008534	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
717962008535	dimerization interface [polypeptide binding]; other site
717962008536	domain crossover interface; other site
717962008537	redox-dependent activation switch; other site
717962008538	histidyl-tRNA synthetase; Region: hisS; TIGR00442
717962008539	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
717962008540	dimer interface [polypeptide binding]; other site
717962008541	motif 1; other site
717962008542	active site
717962008543	motif 2; other site
717962008544	motif 3; other site
717962008545	Protein of unknown function (DUF1104); Region: DUF1104; pfam06518
717962008546	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
717962008547	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
717962008548	dimer interface [polypeptide binding]; other site
717962008549	anticodon binding site; other site
717962008550	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
717962008551	homodimer interface [polypeptide binding]; other site
717962008552	motif 1; other site
717962008553	active site
717962008554	motif 2; other site
717962008555	GAD domain; Region: GAD; pfam02938
717962008556	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
717962008557	motif 3; other site
717962008558	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
717962008559	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
717962008560	dimer interface [polypeptide binding]; other site
717962008561	active site
717962008562	glycine-pyridoxal phosphate binding site [chemical binding]; other site
717962008563	folate binding site [chemical binding]; other site
717962008564	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962008565	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
717962008566	active site
717962008567	motif I; other site
717962008568	motif II; other site
717962008569	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717962008570	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
717962008571	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
717962008572	CAAX protease self-immunity; Region: Abi; pfam02517
717962008573	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
717962008574	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
717962008575	GGGtGRT protein; Region: GGGtGRT; pfam14057
717962008576	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
717962008577	putative active site [active]
717962008578	Transcriptional regulator; Region: Rrf2; cl17282
717962008579	Rrf2 family protein; Region: rrf2_super; TIGR00738
717962008580	FeS assembly ATPase SufC; Region: sufC; TIGR01978
717962008581	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
717962008582	Walker A/P-loop; other site
717962008583	ATP binding site [chemical binding]; other site
717962008584	Q-loop/lid; other site
717962008585	ABC transporter signature motif; other site
717962008586	Walker B; other site
717962008587	D-loop; other site
717962008588	H-loop/switch region; other site
717962008589	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
717962008590	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
717962008591	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
717962008592	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
717962008593	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962008594	catalytic residue [active]
717962008595	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
717962008596	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
717962008597	trimerization site [polypeptide binding]; other site
717962008598	active site
717962008599	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
717962008600	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
717962008601	HD domain; Region: HD_3; cl17350
717962008602	Competence-damaged protein; Region: CinA; pfam02464
717962008603	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
717962008604	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
717962008605	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
717962008606	ligand binding site [chemical binding]; other site
717962008607	flexible hinge region; other site
717962008608	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
717962008609	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
717962008610	ligand binding site [chemical binding]; other site
717962008611	flexible hinge region; other site
717962008612	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
717962008613	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717962008614	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717962008615	catalytic residue [active]
717962008616	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
717962008617	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
717962008618	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
717962008619	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
717962008620	FAD binding site [chemical binding]; other site
717962008621	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
717962008622	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
717962008623	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
717962008624	substrate binding pocket [chemical binding]; other site
717962008625	dimer interface [polypeptide binding]; other site
717962008626	inhibitor binding site; inhibition site
717962008627	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
717962008628	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
717962008629	B12 binding site [chemical binding]; other site
717962008630	cobalt ligand [ion binding]; other site
717962008631	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
717962008632	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
717962008633	enolase; Provisional; Region: eno; PRK00077
717962008634	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
717962008635	dimer interface [polypeptide binding]; other site
717962008636	metal binding site [ion binding]; metal-binding site
717962008637	substrate binding pocket [chemical binding]; other site
717962008638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962008639	Walker A motif; other site
717962008640	ATP binding site [chemical binding]; other site
717962008641	Walker B motif; other site
717962008642	arginine finger; other site
717962008643	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
717962008644	putative active site [active]
717962008645	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717962008646	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717962008647	Walker A/P-loop; other site
717962008648	ATP binding site [chemical binding]; other site
717962008649	Q-loop/lid; other site
717962008650	ABC transporter signature motif; other site
717962008651	Walker B; other site
717962008652	D-loop; other site
717962008653	H-loop/switch region; other site
717962008654	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
717962008655	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
717962008656	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
717962008657	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
717962008658	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
717962008659	putative valine binding site [chemical binding]; other site
717962008660	dimer interface [polypeptide binding]; other site
717962008661	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
717962008662	ketol-acid reductoisomerase; Provisional; Region: PRK05479
717962008663	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
717962008664	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
717962008665	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
717962008666	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
717962008667	NAD(P) binding site [chemical binding]; other site
717962008668	catalytic residues [active]
717962008669	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717962008670	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717962008671	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717962008672	dimerization interface [polypeptide binding]; other site
717962008673	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
717962008674	tartrate dehydrogenase; Region: TTC; TIGR02089
717962008675	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
717962008676	6-phosphogluconate dehydratase; Region: edd; TIGR01196
717962008677	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
717962008678	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
717962008679	PYR/PP interface [polypeptide binding]; other site
717962008680	dimer interface [polypeptide binding]; other site
717962008681	TPP binding site [chemical binding]; other site
717962008682	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
717962008683	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
717962008684	TPP-binding site [chemical binding]; other site
717962008685	dimer interface [polypeptide binding]; other site
717962008686	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
717962008687	homodimer interface [polypeptide binding]; other site
717962008688	substrate-cofactor binding pocket; other site
717962008689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717962008690	catalytic residue [active]
717962008691	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
717962008692	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
717962008693	putative ligand binding site [chemical binding]; other site
717962008694	putative NAD binding site [chemical binding]; other site
717962008695	putative catalytic site [active]
717962008696	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
717962008697	L-serine binding site [chemical binding]; other site
717962008698	ACT domain interface; other site
717962008699	Uncharacterized conserved protein [Function unknown]; Region: COG4198
717962008700	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
717962008701	Mechanosensitive ion channel; Region: MS_channel; pfam00924
717962008702	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717962008703	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717962008704	non-specific DNA binding site [nucleotide binding]; other site
717962008705	salt bridge; other site
717962008706	sequence-specific DNA binding site [nucleotide binding]; other site
717962008707	argininosuccinate lyase; Provisional; Region: PRK00855
717962008708	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
717962008709	active sites [active]
717962008710	tetramer interface [polypeptide binding]; other site
717962008711	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
717962008712	16S/18S rRNA binding site [nucleotide binding]; other site
717962008713	S13e-L30e interaction site [polypeptide binding]; other site
717962008714	25S rRNA binding site [nucleotide binding]; other site
717962008715	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
717962008716	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
717962008717	RNase E interface [polypeptide binding]; other site
717962008718	trimer interface [polypeptide binding]; other site
717962008719	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
717962008720	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
717962008721	RNase E interface [polypeptide binding]; other site
717962008722	trimer interface [polypeptide binding]; other site
717962008723	active site
717962008724	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
717962008725	putative nucleic acid binding region [nucleotide binding]; other site
717962008726	G-X-X-G motif; other site
717962008727	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
717962008728	RNA binding site [nucleotide binding]; other site
717962008729	domain interface; other site
717962008730	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
717962008731	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
717962008732	dimer interface [polypeptide binding]; other site
717962008733	PYR/PP interface [polypeptide binding]; other site
717962008734	TPP binding site [chemical binding]; other site
717962008735	substrate binding site [chemical binding]; other site
717962008736	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
717962008737	Domain of unknown function; Region: EKR; smart00890
717962008738	4Fe-4S binding domain; Region: Fer4_6; pfam12837
717962008739	4Fe-4S binding domain; Region: Fer4; pfam00037
717962008740	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
717962008741	TPP-binding site [chemical binding]; other site
717962008742	dimer interface [polypeptide binding]; other site
717962008743	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
717962008744	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
717962008745	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
717962008746	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
717962008747	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
717962008748	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717962008749	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717962008750	DNA binding residues [nucleotide binding]
717962008751	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
717962008752	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717962008753	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
717962008754	Predicted transcriptional regulators [Transcription]; Region: COG1725
717962008755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717962008756	DNA-binding site [nucleotide binding]; DNA binding site
717962008757	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
717962008758	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
717962008759	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
717962008760	ADP binding site [chemical binding]; other site
717962008761	phosphagen binding site; other site
717962008762	substrate specificity loop; other site
717962008763	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
717962008764	Clp amino terminal domain; Region: Clp_N; pfam02861
717962008765	Clp amino terminal domain; Region: Clp_N; pfam02861
717962008766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962008767	Walker A motif; other site
717962008768	ATP binding site [chemical binding]; other site
717962008769	Walker B motif; other site
717962008770	arginine finger; other site
717962008771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717962008772	Walker A motif; other site
717962008773	ATP binding site [chemical binding]; other site
717962008774	Walker B motif; other site
717962008775	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
717962008776	DNA repair protein RadA; Provisional; Region: PRK11823
717962008777	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
717962008778	Walker A motif/ATP binding site; other site
717962008779	ATP binding site [chemical binding]; other site
717962008780	Walker B motif; other site
717962008781	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
717962008782	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
717962008783	putative NADH binding site [chemical binding]; other site
717962008784	putative active site [active]
717962008785	nudix motif; other site
717962008786	putative metal binding site [ion binding]; other site
717962008787	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717962008788	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
717962008789	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
717962008790	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
717962008791	putative phosphate binding site [ion binding]; other site