-- dump date   	20140619_050215
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
309798000001	Predicted amidohydrolase [General function prediction only]; Region: COG0388
309798000002	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
309798000003	active site
309798000004	catalytic triad [active]
309798000005	dimer interface [polypeptide binding]; other site
309798000006	CAAX protease self-immunity; Region: Abi; pfam02517
309798000007	Methyltransferase domain; Region: Methyltransf_31; pfam13847
309798000008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798000009	S-adenosylmethionine binding site [chemical binding]; other site
309798000010	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
309798000011	dimer interface [polypeptide binding]; other site
309798000012	substrate binding site [chemical binding]; other site
309798000013	ATP binding site [chemical binding]; other site
309798000014	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
309798000015	substrate binding site [chemical binding]; other site
309798000016	multimerization interface [polypeptide binding]; other site
309798000017	ATP binding site [chemical binding]; other site
309798000018	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
309798000019	thiamine phosphate binding site [chemical binding]; other site
309798000020	active site
309798000021	pyrophosphate binding site [ion binding]; other site
309798000022	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
309798000023	ATP cone domain; Region: ATP-cone; pfam03477
309798000024	Class III ribonucleotide reductase; Region: RNR_III; cd01675
309798000025	effector binding site; other site
309798000026	active site
309798000027	Zn binding site [ion binding]; other site
309798000028	glycine loop; other site
309798000029	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
309798000030	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798000031	FeS/SAM binding site; other site
309798000032	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
309798000033	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
309798000034	Walker A/P-loop; other site
309798000035	ATP binding site [chemical binding]; other site
309798000036	Q-loop/lid; other site
309798000037	ABC transporter signature motif; other site
309798000038	Walker B; other site
309798000039	D-loop; other site
309798000040	H-loop/switch region; other site
309798000041	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
309798000042	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
309798000043	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
309798000044	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
309798000045	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
309798000046	substrate binding pocket [chemical binding]; other site
309798000047	dimer interface [polypeptide binding]; other site
309798000048	inhibitor binding site; inhibition site
309798000049	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
309798000050	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
309798000051	B12 binding site [chemical binding]; other site
309798000052	Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527
309798000053	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
309798000054	nucleotide binding site [chemical binding]; other site
309798000055	substrate binding site [chemical binding]; other site
309798000056	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
309798000057	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
309798000058	Domain of unknown function DUF39; Region: DUF39; pfam01837
309798000059	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
309798000060	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
309798000061	hypothetical protein; Provisional; Region: PRK04334
309798000062	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
309798000063	FAD binding site [chemical binding]; other site
309798000064	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
309798000065	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
309798000066	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
309798000067	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
309798000068	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
309798000069	DNA binding residues [nucleotide binding]
309798000070	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
309798000071	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
309798000072	Walker A/P-loop; other site
309798000073	ATP binding site [chemical binding]; other site
309798000074	Q-loop/lid; other site
309798000075	ABC transporter signature motif; other site
309798000076	Walker B; other site
309798000077	D-loop; other site
309798000078	H-loop/switch region; other site
309798000079	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
309798000080	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
309798000081	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
309798000082	active site
309798000083	phosphorylation site [posttranslational modification]
309798000084	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
309798000085	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
309798000086	active site
309798000087	P-loop; other site
309798000088	phosphorylation site [posttranslational modification]
309798000089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
309798000090	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
309798000091	putative active site [active]
309798000092	heme pocket [chemical binding]; other site
309798000093	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
309798000094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
309798000095	putative active site [active]
309798000096	heme pocket [chemical binding]; other site
309798000097	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
309798000098	dimer interface [polypeptide binding]; other site
309798000099	phosphorylation site [posttranslational modification]
309798000100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798000101	ATP binding site [chemical binding]; other site
309798000102	Mg2+ binding site [ion binding]; other site
309798000103	G-X-G motif; other site
309798000104	Response regulator receiver domain; Region: Response_reg; pfam00072
309798000105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
309798000106	active site
309798000107	phosphorylation site [posttranslational modification]
309798000108	intermolecular recognition site; other site
309798000109	dimerization interface [polypeptide binding]; other site
309798000110	Response regulator receiver domain; Region: Response_reg; pfam00072
309798000111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
309798000112	active site
309798000113	phosphorylation site [posttranslational modification]
309798000114	intermolecular recognition site; other site
309798000115	dimerization interface [polypeptide binding]; other site
309798000116	PAS domain S-box; Region: sensory_box; TIGR00229
309798000117	PAS domain; Region: PAS; smart00091
309798000118	putative active site [active]
309798000119	heme pocket [chemical binding]; other site
309798000120	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
309798000121	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798000122	Zn2+ binding site [ion binding]; other site
309798000123	Mg2+ binding site [ion binding]; other site
309798000124	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
309798000125	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
309798000126	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798000127	catalytic residue [active]
309798000128	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
309798000129	substrate binding site [chemical binding]; other site
309798000130	active site
309798000131	catalytic residues [active]
309798000132	heterodimer interface [polypeptide binding]; other site
309798000133	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
309798000134	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
309798000135	catalytic residues [active]
309798000136	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
309798000137	active site
309798000138	substrate binding pocket [chemical binding]; other site
309798000139	homodimer interaction site [polypeptide binding]; other site
309798000140	Protein of unknown function; Region: YhfT; pfam10797
309798000141	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000142	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
309798000143	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
309798000144	active site
309798000145	DNA binding site [nucleotide binding]
309798000146	Int/Topo IB signature motif; other site
309798000147	proteasome-activating nucleotidase; Provisional; Region: PRK03992
309798000148	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
309798000149	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
309798000150	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
309798000151	DXD motif; other site
309798000152	RmuC family; Region: RmuC; pfam02646
309798000153	Staphylococcal nuclease homologues; Region: SNc; smart00318
309798000154	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
309798000155	Catalytic site; other site
309798000156	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
309798000157	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
309798000158	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
309798000159	HsdM N-terminal domain; Region: HsdM_N; pfam12161
309798000160	Uncharacterized conserved protein [Function unknown]; Region: COG3342
309798000161	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
309798000162	Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823
309798000163	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
309798000164	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
309798000165	active site
309798000166	catalytic tetrad [active]
309798000167	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
309798000168	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
309798000169	trimer interface [polypeptide binding]; other site
309798000170	active site
309798000171	substrate binding site [chemical binding]; other site
309798000172	CoA binding site [chemical binding]; other site
309798000173	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
309798000174	dimer interface [polypeptide binding]; other site
309798000175	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
309798000176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798000177	catalytic residue [active]
309798000178	peroxiredoxin; Provisional; Region: PRK13189
309798000179	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
309798000180	dimer interface [polypeptide binding]; other site
309798000181	decamer (pentamer of dimers) interface [polypeptide binding]; other site
309798000182	catalytic triad [active]
309798000183	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
309798000184	Part of AAA domain; Region: AAA_19; pfam13245
309798000185	Family description; Region: UvrD_C_2; pfam13538
309798000186	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
309798000187	MoaE interaction surface [polypeptide binding]; other site
309798000188	MoeB interaction surface [polypeptide binding]; other site
309798000189	thiocarboxylated glycine; other site
309798000190	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
309798000191	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
309798000192	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
309798000193	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
309798000194	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
309798000195	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
309798000196	DnaA N-terminal domain; Region: DnaA_N; pfam11638
309798000197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798000198	Walker A motif; other site
309798000199	ATP binding site [chemical binding]; other site
309798000200	Walker B motif; other site
309798000201	arginine finger; other site
309798000202	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
309798000203	DnaA box-binding interface [nucleotide binding]; other site
309798000204	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
309798000205	DNA polymerase III subunit beta; Validated; Region: PRK05643
309798000206	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
309798000207	putative DNA binding surface [nucleotide binding]; other site
309798000208	dimer interface [polypeptide binding]; other site
309798000209	beta-clamp/clamp loader binding surface; other site
309798000210	beta-clamp/translesion DNA polymerase binding surface; other site
309798000211	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
309798000212	RNA binding surface [nucleotide binding]; other site
309798000213	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
309798000214	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
309798000215	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000216	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
309798000217	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
309798000218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798000219	dimer interface [polypeptide binding]; other site
309798000220	conserved gate region; other site
309798000221	putative PBP binding loops; other site
309798000222	ABC-ATPase subunit interface; other site
309798000223	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
309798000224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798000225	dimer interface [polypeptide binding]; other site
309798000226	conserved gate region; other site
309798000227	putative PBP binding loops; other site
309798000228	ABC-ATPase subunit interface; other site
309798000229	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
309798000230	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
309798000231	active site
309798000232	homodimer interface [polypeptide binding]; other site
309798000233	catalytic site [active]
309798000234	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
309798000235	putative ligand binding site [chemical binding]; other site
309798000236	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
309798000237	putative ligand binding site [chemical binding]; other site
309798000238	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000239	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
309798000240	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
309798000241	Walker A motif; other site
309798000242	PBP superfamily domain; Region: PBP_like_2; pfam12849
309798000243	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000244	PBP superfamily domain; Region: PBP_like_2; pfam12849
309798000245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
309798000246	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
309798000247	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798000248	Walker A/P-loop; other site
309798000249	ATP binding site [chemical binding]; other site
309798000250	Q-loop/lid; other site
309798000251	ABC transporter signature motif; other site
309798000252	Walker B; other site
309798000253	D-loop; other site
309798000254	H-loop/switch region; other site
309798000255	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000256	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000257	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
309798000258	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
309798000259	putative active site [active]
309798000260	catalytic triad [active]
309798000261	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
309798000262	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
309798000263	catalytic residues [active]
309798000264	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
309798000265	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
309798000266	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000267	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
309798000268	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
309798000269	trans-sialidase; Provisional; Region: PTZ00334
309798000270	Cache domain; Region: Cache_1; pfam02743
309798000271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
309798000272	dimerization interface [polypeptide binding]; other site
309798000273	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
309798000274	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
309798000275	dimer interface [polypeptide binding]; other site
309798000276	putative CheW interface [polypeptide binding]; other site
309798000277	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
309798000278	intersubunit interface [polypeptide binding]; other site
309798000279	active site
309798000280	Zn2+ binding site [ion binding]; other site
309798000281	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
309798000282	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
309798000283	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
309798000284	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
309798000285	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
309798000286	putative GTP cyclohydrolase; Provisional; Region: PRK13674
309798000287	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
309798000288	active site
309798000289	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
309798000290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
309798000291	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
309798000292	DNA binding residues [nucleotide binding]
309798000293	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
309798000294	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
309798000295	PspC domain; Region: PspC; pfam04024
309798000296	PspC domain; Region: PspC; pfam04024
309798000297	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
309798000298	AAA ATPase domain; Region: AAA_16; pfam13191
309798000299	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
309798000300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
309798000301	TPR motif; other site
309798000302	binding surface
309798000303	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
309798000304	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
309798000305	metal binding site [ion binding]; metal-binding site
309798000306	active site
309798000307	I-site; other site
309798000308	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
309798000309	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
309798000310	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
309798000311	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
309798000312	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
309798000313	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
309798000314	active site
309798000315	GMP synthase; Reviewed; Region: guaA; PRK00074
309798000316	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
309798000317	AMP/PPi binding site [chemical binding]; other site
309798000318	candidate oxyanion hole; other site
309798000319	catalytic triad [active]
309798000320	potential glutamine specificity residues [chemical binding]; other site
309798000321	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
309798000322	ATP Binding subdomain [chemical binding]; other site
309798000323	Ligand Binding sites [chemical binding]; other site
309798000324	Dimerization subdomain; other site
309798000325	Uncharacterized conserved protein [Function unknown]; Region: COG1633
309798000326	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
309798000327	diiron binding motif [ion binding]; other site
309798000328	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
309798000329	ADP-ribose binding site [chemical binding]; other site
309798000330	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
309798000331	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
309798000332	GatB domain; Region: GatB_Yqey; smart00845
309798000333	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
309798000334	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
309798000335	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
309798000336	S-layer homology domain; Region: SLH; pfam00395
309798000337	S-layer homology domain; Region: SLH; pfam00395
309798000338	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
309798000339	peptide binding site [polypeptide binding]; other site
309798000340	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
309798000341	dimer interface [polypeptide binding]; other site
309798000342	S-layer homology domain; Region: SLH; pfam00395
309798000343	S-layer homology domain; Region: SLH; pfam00395
309798000344	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
309798000345	peptide binding site [polypeptide binding]; other site
309798000346	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
309798000347	dimer interface [polypeptide binding]; other site
309798000348	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
309798000349	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
309798000350	nucleotide binding pocket [chemical binding]; other site
309798000351	K-X-D-G motif; other site
309798000352	catalytic site [active]
309798000353	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
309798000354	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
309798000355	helix-hairpin-helix signature motif; other site
309798000356	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
309798000357	Dimer interface [polypeptide binding]; other site
309798000358	BRCT sequence motif; other site
309798000359	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
309798000360	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
309798000361	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798000362	FeS/SAM binding site; other site
309798000363	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
309798000364	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
309798000365	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
309798000366	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
309798000367	MoaE interaction surface [polypeptide binding]; other site
309798000368	MoeB interaction surface [polypeptide binding]; other site
309798000369	thiocarboxylated glycine; other site
309798000370	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
309798000371	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
309798000372	G1 box; other site
309798000373	GTP/Mg2+ binding site [chemical binding]; other site
309798000374	Switch I region; other site
309798000375	G2 box; other site
309798000376	Switch II region; other site
309798000377	G3 box; other site
309798000378	G4 box; other site
309798000379	G5 box; other site
309798000380	biotin synthase; Provisional; Region: PRK07094
309798000381	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798000382	FeS/SAM binding site; other site
309798000383	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
309798000384	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
309798000385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798000386	FeS/SAM binding site; other site
309798000387	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
309798000388	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
309798000389	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
309798000390	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798000391	FeS/SAM binding site; other site
309798000392	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
309798000393	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
309798000394	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
309798000395	homotetramer interface [polypeptide binding]; other site
309798000396	ligand binding site [chemical binding]; other site
309798000397	catalytic site [active]
309798000398	NAD binding site [chemical binding]; other site
309798000399	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
309798000400	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
309798000401	catalytic triad [active]
309798000402	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
309798000403	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
309798000404	metal binding site [ion binding]; metal-binding site
309798000405	active site
309798000406	I-site; other site
309798000407	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
309798000408	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
309798000409	trmE is a tRNA modification GTPase; Region: trmE; cd04164
309798000410	G1 box; other site
309798000411	GTP/Mg2+ binding site [chemical binding]; other site
309798000412	Switch I region; other site
309798000413	G2 box; other site
309798000414	Switch II region; other site
309798000415	G3 box; other site
309798000416	G4 box; other site
309798000417	G5 box; other site
309798000418	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
309798000419	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
309798000420	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
309798000421	Beta-Casp domain; Region: Beta-Casp; smart01027
309798000422	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
309798000423	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
309798000424	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
309798000425	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
309798000426	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
309798000427	Chromate transporter; Region: Chromate_transp; pfam02417
309798000428	Chromate transporter; Region: Chromate_transp; pfam02417
309798000429	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
309798000430	EamA-like transporter family; Region: EamA; pfam00892
309798000431	EamA-like transporter family; Region: EamA; pfam00892
309798000432	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
309798000433	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
309798000434	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
309798000435	NAD(P) binding site [chemical binding]; other site
309798000436	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
309798000437	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
309798000438	tetramer interface [polypeptide binding]; other site
309798000439	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798000440	catalytic residue [active]
309798000441	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
309798000442	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
309798000443	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798000444	active site
309798000445	metal binding site [ion binding]; metal-binding site
309798000446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798000447	H+ Antiporter protein; Region: 2A0121; TIGR00900
309798000448	putative substrate translocation pore; other site
309798000449	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
309798000450	active site
309798000451	dimer interfaces [polypeptide binding]; other site
309798000452	catalytic residues [active]
309798000453	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
309798000454	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
309798000455	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
309798000456	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
309798000457	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
309798000458	active site
309798000459	substrate binding site [chemical binding]; other site
309798000460	metal binding site [ion binding]; metal-binding site
309798000461	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
309798000462	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
309798000463	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
309798000464	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
309798000465	motif II; other site
309798000466	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
309798000467	dimerization interface [polypeptide binding]; other site
309798000468	putative Zn2+ binding site [ion binding]; other site
309798000469	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
309798000470	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798000471	active site
309798000472	metal binding site [ion binding]; metal-binding site
309798000473	DRTGG domain; Region: DRTGG; pfam07085
309798000474	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
309798000475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
309798000476	ATP binding site [chemical binding]; other site
309798000477	Mg2+ binding site [ion binding]; other site
309798000478	G-X-G motif; other site
309798000479	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
309798000480	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
309798000481	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
309798000482	Putative Fe-S cluster; Region: FeS; cl17515
309798000483	DRTGG domain; Region: DRTGG; pfam07085
309798000484	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
309798000485	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
309798000486	active site
309798000487	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
309798000488	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
309798000489	putative dimer interface [polypeptide binding]; other site
309798000490	[2Fe-2S] cluster binding site [ion binding]; other site
309798000491	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
309798000492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798000493	ATP binding site [chemical binding]; other site
309798000494	Mg2+ binding site [ion binding]; other site
309798000495	G-X-G motif; other site
309798000496	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
309798000497	dimer interface [polypeptide binding]; other site
309798000498	[2Fe-2S] cluster binding site [ion binding]; other site
309798000499	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
309798000500	dimer interface [polypeptide binding]; other site
309798000501	[2Fe-2S] cluster binding site [ion binding]; other site
309798000502	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
309798000503	SLBB domain; Region: SLBB; pfam10531
309798000504	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
309798000505	4Fe-4S binding domain; Region: Fer4; pfam00037
309798000506	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
309798000507	4Fe-4S binding domain; Region: Fer4; pfam00037
309798000508	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
309798000509	catalytic loop [active]
309798000510	iron binding site [ion binding]; other site
309798000511	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
309798000512	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
309798000513	4Fe-4S binding domain; Region: Fer4; pfam00037
309798000514	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
309798000515	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
309798000516	GntP family permease; Region: GntP_permease; pfam02447
309798000517	fructuronate transporter; Provisional; Region: PRK10034; cl15264
309798000518	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
309798000519	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
309798000520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
309798000521	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
309798000522	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
309798000523	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
309798000524	Peptidase family C69; Region: Peptidase_C69; cl17793
309798000525	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798000526	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
309798000527	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
309798000528	EamA-like transporter family; Region: EamA; pfam00892
309798000529	EamA-like transporter family; Region: EamA; pfam00892
309798000530	AIR carboxylase; Region: AIRC; pfam00731
309798000531	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
309798000532	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
309798000533	ATP binding site [chemical binding]; other site
309798000534	active site
309798000535	substrate binding site [chemical binding]; other site
309798000536	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
309798000537	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
309798000538	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
309798000539	putative active site [active]
309798000540	catalytic triad [active]
309798000541	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
309798000542	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
309798000543	dimerization interface [polypeptide binding]; other site
309798000544	ATP binding site [chemical binding]; other site
309798000545	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
309798000546	dimerization interface [polypeptide binding]; other site
309798000547	ATP binding site [chemical binding]; other site
309798000548	amidophosphoribosyltransferase; Provisional; Region: PRK05793
309798000549	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
309798000550	active site
309798000551	tetramer interface [polypeptide binding]; other site
309798000552	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798000553	active site
309798000554	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
309798000555	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
309798000556	dimerization interface [polypeptide binding]; other site
309798000557	putative ATP binding site [chemical binding]; other site
309798000558	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
309798000559	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
309798000560	active site
309798000561	substrate binding site [chemical binding]; other site
309798000562	cosubstrate binding site; other site
309798000563	catalytic site [active]
309798000564	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
309798000565	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
309798000566	purine monophosphate binding site [chemical binding]; other site
309798000567	dimer interface [polypeptide binding]; other site
309798000568	putative catalytic residues [active]
309798000569	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
309798000570	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
309798000571	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
309798000572	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
309798000573	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
309798000574	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
309798000575	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
309798000576	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
309798000577	SxDxEG motif; other site
309798000578	putative active site [active]
309798000579	putative metal binding site [ion binding]; other site
309798000580	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
309798000581	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
309798000582	Ligand Binding Site [chemical binding]; other site
309798000583	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
309798000584	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
309798000585	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
309798000586	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
309798000587	putative NADP binding site [chemical binding]; other site
309798000588	putative substrate binding site [chemical binding]; other site
309798000589	active site
309798000590	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
309798000591	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
309798000592	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
309798000593	Lamin Tail Domain; Region: LTD; pfam00932
309798000594	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
309798000595	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
309798000596	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
309798000597	catalytic residue [active]
309798000598	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
309798000599	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
309798000600	CPxP  motif; other site
309798000601	DsrE/DsrF-like family; Region: DrsE; pfam02635
309798000602	glycerate kinase; Region: TIGR00045
309798000603	fructuronate transporter; Provisional; Region: PRK10034; cl15264
309798000604	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
309798000605	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
309798000606	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
309798000607	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
309798000608	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
309798000609	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
309798000610	putative substrate binding site [chemical binding]; other site
309798000611	putative ATP binding site [chemical binding]; other site
309798000612	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
309798000613	active site
309798000614	phosphorylation site [posttranslational modification]
309798000615	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
309798000616	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
309798000617	active site
309798000618	P-loop; other site
309798000619	phosphorylation site [posttranslational modification]
309798000620	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
309798000621	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
309798000622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
309798000623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
309798000624	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
309798000625	catalytic residues [active]
309798000626	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
309798000627	Glycine reductase complex selenoprotein A; Region: GRDA; cl04705
309798000628	putative glycine/sarcosine/betaine reductase complex protein A; Provisional; Region: PRK14717
309798000629	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
309798000630	selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918
309798000631	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
309798000632	dimer interface [polypeptide binding]; other site
309798000633	active site
309798000634	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
309798000635	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
309798000636	dimerization interface [polypeptide binding]; other site
309798000637	putative ATP binding site [chemical binding]; other site
309798000638	selenocysteine synthase; Provisional; Region: PRK04311
309798000639	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
309798000640	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
309798000641	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
309798000642	catalytic residue [active]
309798000643	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
309798000644	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
309798000645	G1 box; other site
309798000646	putative GEF interaction site [polypeptide binding]; other site
309798000647	GTP/Mg2+ binding site [chemical binding]; other site
309798000648	Switch I region; other site
309798000649	G2 box; other site
309798000650	G3 box; other site
309798000651	Switch II region; other site
309798000652	G4 box; other site
309798000653	G5 box; other site
309798000654	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
309798000655	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
309798000656	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
309798000657	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
309798000658	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
309798000659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
309798000660	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
309798000661	active site
309798000662	motif I; other site
309798000663	motif II; other site
309798000664	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
309798000665	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
309798000666	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
309798000667	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
309798000668	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
309798000669	Walker A/P-loop; other site
309798000670	ATP binding site [chemical binding]; other site
309798000671	Q-loop/lid; other site
309798000672	ABC transporter signature motif; other site
309798000673	Walker B; other site
309798000674	D-loop; other site
309798000675	H-loop/switch region; other site
309798000676	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
309798000677	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
309798000678	Walker A/P-loop; other site
309798000679	ATP binding site [chemical binding]; other site
309798000680	Q-loop/lid; other site
309798000681	ABC transporter signature motif; other site
309798000682	Walker B; other site
309798000683	D-loop; other site
309798000684	H-loop/switch region; other site
309798000685	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
309798000686	histidinol-phosphatase; Provisional; Region: PRK05588
309798000687	active site
309798000688	Protein of unknown function (DUF554); Region: DUF554; pfam04474
309798000689	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
309798000690	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
309798000691	PA/protease or protease-like domain interface [polypeptide binding]; other site
309798000692	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
309798000693	Peptidase family M28; Region: Peptidase_M28; pfam04389
309798000694	metal binding site [ion binding]; metal-binding site
309798000695	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
309798000696	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798000697	Zn2+ binding site [ion binding]; other site
309798000698	Mg2+ binding site [ion binding]; other site
309798000699	diaminopimelate aminotransferase; Provisional; Region: PRK13983
309798000700	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
309798000701	metal binding site [ion binding]; metal-binding site
309798000702	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
309798000703	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
309798000704	intersubunit interface [polypeptide binding]; other site
309798000705	active site
309798000706	zinc binding site [ion binding]; other site
309798000707	Na+ binding site [ion binding]; other site
309798000708	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
309798000709	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
309798000710	FMN binding site [chemical binding]; other site
309798000711	substrate binding site [chemical binding]; other site
309798000712	putative catalytic residue [active]
309798000713	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
309798000714	Putative zinc-finger; Region: zf-HC2; pfam13490
309798000715	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
309798000716	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
309798000717	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
309798000718	DNA binding residues [nucleotide binding]
309798000719	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
309798000720	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
309798000721	dimer interface [polypeptide binding]; other site
309798000722	active site
309798000723	acyl carrier protein; Provisional; Region: acpP; PRK00982
309798000724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
309798000725	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
309798000726	NAD(P) binding site [chemical binding]; other site
309798000727	active site
309798000728	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
309798000729	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
309798000730	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
309798000731	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
309798000732	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
309798000733	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
309798000734	ATP binding site [chemical binding]; other site
309798000735	substrate interface [chemical binding]; other site
309798000736	Major Facilitator Superfamily; Region: MFS_1; pfam07690
309798000737	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
309798000738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798000739	putative substrate translocation pore; other site
309798000740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798000741	Major Facilitator Superfamily; Region: MFS_1; pfam07690
309798000742	putative substrate translocation pore; other site
309798000743	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
309798000744	active site pocket [active]
309798000745	oxyanion hole [active]
309798000746	catalytic triad [active]
309798000747	active site nucleophile [active]
309798000748	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
309798000749	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
309798000750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798000751	Walker A/P-loop; other site
309798000752	ATP binding site [chemical binding]; other site
309798000753	Q-loop/lid; other site
309798000754	ABC transporter signature motif; other site
309798000755	Walker B; other site
309798000756	D-loop; other site
309798000757	H-loop/switch region; other site
309798000758	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798000759	Major Facilitator Superfamily; Region: MFS_1; pfam07690
309798000760	putative substrate translocation pore; other site
309798000761	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
309798000762	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
309798000763	active site
309798000764	catalytic site [active]
309798000765	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
309798000766	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
309798000767	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
309798000768	nucleophilic elbow; other site
309798000769	catalytic triad; other site
309798000770	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
309798000771	Esterase/lipase [General function prediction only]; Region: COG1647
309798000772	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
309798000773	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
309798000774	glycerol kinase; Provisional; Region: glpK; PRK00047
309798000775	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
309798000776	N- and C-terminal domain interface [polypeptide binding]; other site
309798000777	active site
309798000778	MgATP binding site [chemical binding]; other site
309798000779	catalytic site [active]
309798000780	metal binding site [ion binding]; metal-binding site
309798000781	glycerol binding site [chemical binding]; other site
309798000782	homotetramer interface [polypeptide binding]; other site
309798000783	homodimer interface [polypeptide binding]; other site
309798000784	FBP binding site [chemical binding]; other site
309798000785	protein IIAGlc interface [polypeptide binding]; other site
309798000786	Predicted dehydrogenase [General function prediction only]; Region: COG0579
309798000787	hydroxyglutarate oxidase; Provisional; Region: PRK11728
309798000788	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
309798000789	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
309798000790	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
309798000791	Protein of unknown function (DUF1667); Region: DUF1667; cl17602
309798000792	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
309798000793	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798000794	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
309798000795	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
309798000796	DAK2 domain; Region: Dak2; pfam02734
309798000797	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
309798000798	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
309798000799	generic binding surface II; other site
309798000800	ssDNA binding site; other site
309798000801	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
309798000802	ATP binding site [chemical binding]; other site
309798000803	putative Mg++ binding site [ion binding]; other site
309798000804	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
309798000805	nucleotide binding region [chemical binding]; other site
309798000806	ATP-binding site [chemical binding]; other site
309798000807	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
309798000808	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
309798000809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798000810	homodimer interface [polypeptide binding]; other site
309798000811	catalytic residue [active]
309798000812	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
309798000813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798000814	S-adenosylmethionine binding site [chemical binding]; other site
309798000815	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182
309798000816	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
309798000817	active site
309798000818	metal-binding site [ion binding]
309798000819	nucleotide-binding site [chemical binding]; other site
309798000820	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
309798000821	substrate binding site [chemical binding]; other site
309798000822	Mn binding site [ion binding]; other site
309798000823	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
309798000824	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
309798000825	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
309798000826	Walker A/P-loop; other site
309798000827	ATP binding site [chemical binding]; other site
309798000828	Q-loop/lid; other site
309798000829	ABC transporter signature motif; other site
309798000830	Walker B; other site
309798000831	D-loop; other site
309798000832	H-loop/switch region; other site
309798000833	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
309798000834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798000835	dimer interface [polypeptide binding]; other site
309798000836	conserved gate region; other site
309798000837	putative PBP binding loops; other site
309798000838	ABC-ATPase subunit interface; other site
309798000839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
309798000840	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413
309798000841	PilZ domain; Region: PilZ; pfam07238
309798000842	Phospholipid methyltransferase; Region: PEMT; pfam04191
309798000843	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
309798000844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
309798000845	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
309798000846	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
309798000847	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
309798000848	putative binding surface; other site
309798000849	active site
309798000850	P2 response regulator binding domain; Region: P2; pfam07194
309798000851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798000852	ATP binding site [chemical binding]; other site
309798000853	Mg2+ binding site [ion binding]; other site
309798000854	G-X-G motif; other site
309798000855	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
309798000856	CheC-like family; Region: CheC; pfam04509
309798000857	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
309798000858	CheC-like family; Region: CheC; pfam04509
309798000859	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
309798000860	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
309798000861	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
309798000862	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
309798000863	DNA binding residues [nucleotide binding]
309798000864	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
309798000865	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
309798000866	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
309798000867	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
309798000868	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
309798000869	HDOD domain; Region: HDOD; pfam08668
309798000870	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798000871	Zn2+ binding site [ion binding]; other site
309798000872	Mg2+ binding site [ion binding]; other site
309798000873	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
309798000874	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
309798000875	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
309798000876	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
309798000877	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
309798000878	Global regulator protein family; Region: CsrA; pfam02599
309798000879	O-Antigen ligase; Region: Wzy_C; pfam04932
309798000880	Flagellar protein FliS; Region: FliS; cl00654
309798000881	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
309798000882	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
309798000883	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
309798000884	FlaG protein; Region: FlaG; cl00591
309798000885	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
309798000886	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
309798000887	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
309798000888	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
309798000889	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
309798000890	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
309798000891	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
309798000892	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
309798000893	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
309798000894	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
309798000895	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
309798000896	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
309798000897	MgtE intracellular N domain; Region: MgtE_N; smart00924
309798000898	FliG C-terminal domain; Region: FliG_C; pfam01706
309798000899	flagellar assembly protein H; Validated; Region: fliH; PRK05687
309798000900	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
309798000901	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
309798000902	Walker A motif/ATP binding site; other site
309798000903	Walker B motif; other site
309798000904	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
309798000905	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
309798000906	flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637
309798000907	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
309798000908	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
309798000909	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
309798000910	Flagellar protein (FlbD); Region: FlbD; pfam06289
309798000911	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
309798000912	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
309798000913	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
309798000914	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
309798000915	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
309798000916	ligand binding site [chemical binding]; other site
309798000917	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
309798000918	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
309798000919	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
309798000920	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
309798000921	Response regulator receiver domain; Region: Response_reg; pfam00072
309798000922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
309798000923	active site
309798000924	phosphorylation site [posttranslational modification]
309798000925	intermolecular recognition site; other site
309798000926	dimerization interface [polypeptide binding]; other site
309798000927	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
309798000928	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
309798000929	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
309798000930	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
309798000931	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
309798000932	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
309798000933	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
309798000934	FHIPEP family; Region: FHIPEP; pfam00771
309798000935	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
309798000936	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
309798000937	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
309798000938	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
309798000939	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
309798000940	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
309798000941	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
309798000942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
309798000943	active site
309798000944	phosphorylation site [posttranslational modification]
309798000945	intermolecular recognition site; other site
309798000946	dimerization interface [polypeptide binding]; other site
309798000947	CheB methylesterase; Region: CheB_methylest; pfam01339
309798000948	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
309798000949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798000950	S-adenosylmethionine binding site [chemical binding]; other site
309798000951	cell division protein FtsA; Region: ftsA; TIGR01174
309798000952	Cell division protein FtsA; Region: FtsA; cl17206
309798000953	Cell division protein FtsA; Region: FtsA; pfam14450
309798000954	Protein of unknown function (DUF342); Region: DUF342; pfam03961
309798000955	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
309798000956	Mechanosensitive ion channel; Region: MS_channel; pfam00924
309798000957	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
309798000958	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
309798000959	intersubunit interface [polypeptide binding]; other site
309798000960	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
309798000961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798000962	Walker A/P-loop; other site
309798000963	ATP binding site [chemical binding]; other site
309798000964	Q-loop/lid; other site
309798000965	ABC transporter signature motif; other site
309798000966	Walker B; other site
309798000967	D-loop; other site
309798000968	H-loop/switch region; other site
309798000969	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
309798000970	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
309798000971	dimer interface [polypeptide binding]; other site
309798000972	putative PBP binding regions; other site
309798000973	ABC-ATPase subunit  interface; other site
309798000974	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
309798000975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798000976	Walker A/P-loop; other site
309798000977	ATP binding site [chemical binding]; other site
309798000978	Q-loop/lid; other site
309798000979	ABC transporter signature motif; other site
309798000980	Walker B; other site
309798000981	D-loop; other site
309798000982	H-loop/switch region; other site
309798000983	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
309798000984	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
309798000985	YtxH-like protein; Region: YtxH; pfam12732
309798000986	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
309798000987	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
309798000988	HSP70 interaction site [polypeptide binding]; other site
309798000989	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
309798000990	Zn binding sites [ion binding]; other site
309798000991	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
309798000992	dimer interface [polypeptide binding]; other site
309798000993	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
309798000994	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
309798000995	nucleotide binding site [chemical binding]; other site
309798000996	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
309798000997	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
309798000998	active site
309798000999	Protein of unknown function (DUF401); Region: DUF401; cl00830
309798001000	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
309798001001	active site
309798001002	catalytic residues [active]
309798001003	metal binding site [ion binding]; metal-binding site
309798001004	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
309798001005	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
309798001006	putative active site [active]
309798001007	substrate binding site [chemical binding]; other site
309798001008	putative cosubstrate binding site; other site
309798001009	catalytic site [active]
309798001010	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
309798001011	substrate binding site [chemical binding]; other site
309798001012	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
309798001013	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
309798001014	Predicted GTPases [General function prediction only]; Region: COG1162
309798001015	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
309798001016	GTPase/Zn-binding domain interface [polypeptide binding]; other site
309798001017	GTP/Mg2+ binding site [chemical binding]; other site
309798001018	G4 box; other site
309798001019	G5 box; other site
309798001020	G1 box; other site
309798001021	Switch I region; other site
309798001022	G2 box; other site
309798001023	G3 box; other site
309798001024	Switch II region; other site
309798001025	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
309798001026	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
309798001027	substrate binding site [chemical binding]; other site
309798001028	hexamer interface [polypeptide binding]; other site
309798001029	metal binding site [ion binding]; metal-binding site
309798001030	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
309798001031	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
309798001032	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
309798001033	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
309798001034	Walker A/P-loop; other site
309798001035	ATP binding site [chemical binding]; other site
309798001036	Q-loop/lid; other site
309798001037	ABC transporter signature motif; other site
309798001038	Walker B; other site
309798001039	D-loop; other site
309798001040	H-loop/switch region; other site
309798001041	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
309798001042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
309798001043	active site
309798001044	phosphorylation site [posttranslational modification]
309798001045	intermolecular recognition site; other site
309798001046	dimerization interface [polypeptide binding]; other site
309798001047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798001048	Walker A motif; other site
309798001049	ATP binding site [chemical binding]; other site
309798001050	Walker B motif; other site
309798001051	arginine finger; other site
309798001052	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
309798001053	Bacterial sugar transferase; Region: Bac_transf; pfam02397
309798001054	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
309798001055	IHF - DNA interface [nucleotide binding]; other site
309798001056	IHF dimer interface [polypeptide binding]; other site
309798001057	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
309798001058	generic binding surface I; other site
309798001059	generic binding surface II; other site
309798001060	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798001061	Zn2+ binding site [ion binding]; other site
309798001062	Mg2+ binding site [ion binding]; other site
309798001063	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
309798001064	active site
309798001065	intersubunit interface [polypeptide binding]; other site
309798001066	Zn2+ binding site [ion binding]; other site
309798001067	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
309798001068	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
309798001069	ATP-binding site [chemical binding]; other site
309798001070	Sugar specificity; other site
309798001071	Pyrimidine base specificity; other site
309798001072	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
309798001073	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
309798001074	oligomer interface [polypeptide binding]; other site
309798001075	putative active site [active]
309798001076	metal binding site [ion binding]; metal-binding site
309798001077	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
309798001078	MarR family; Region: MarR_2; cl17246
309798001079	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
309798001080	FMN binding site [chemical binding]; other site
309798001081	dimer interface [polypeptide binding]; other site
309798001082	DsrE/DsrF-like family; Region: DrsE; cl00672
309798001083	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
309798001084	FMN binding site [chemical binding]; other site
309798001085	dimer interface [polypeptide binding]; other site
309798001086	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
309798001087	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
309798001088	Sugar fermentation stimulation protein; Region: SfsA; cl00647
309798001089	N-glycosylase/DNA lyase; Provisional; Region: PRK01229
309798001090	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
309798001091	minor groove reading motif; other site
309798001092	helix-hairpin-helix signature motif; other site
309798001093	substrate binding pocket [chemical binding]; other site
309798001094	active site
309798001095	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
309798001096	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
309798001097	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
309798001098	TPP-binding site [chemical binding]; other site
309798001099	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
309798001100	PYR/PP interface [polypeptide binding]; other site
309798001101	dimer interface [polypeptide binding]; other site
309798001102	TPP binding site [chemical binding]; other site
309798001103	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
309798001104	Isochorismatase family; Region: Isochorismatase; pfam00857
309798001105	catalytic triad [active]
309798001106	metal binding site [ion binding]; metal-binding site
309798001107	conserved cis-peptide bond; other site
309798001108	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
309798001109	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
309798001110	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
309798001111	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
309798001112	minor groove reading motif; other site
309798001113	endonuclease III; Region: ENDO3c; smart00478
309798001114	helix-hairpin-helix signature motif; other site
309798001115	substrate binding pocket [chemical binding]; other site
309798001116	active site
309798001117	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
309798001118	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
309798001119	Methyltransferase domain; Region: Methyltransf_23; pfam13489
309798001120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798001121	S-adenosylmethionine binding site [chemical binding]; other site
309798001122	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
309798001123	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
309798001124	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
309798001125	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
309798001126	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
309798001127	active site
309798001128	Zn binding site [ion binding]; other site
309798001129	Membrane protein of unknown function; Region: DUF360; pfam04020
309798001130	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
309798001131	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
309798001132	DRTGG domain; Region: DRTGG; pfam07085
309798001133	DHH family; Region: DHH; pfam01368
309798001134	DHHA2 domain; Region: DHHA2; pfam02833
309798001135	Peptidase family M48; Region: Peptidase_M48; cl12018
309798001136	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
309798001137	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
309798001138	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
309798001139	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
309798001140	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
309798001141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
309798001142	NAD(P) binding site [chemical binding]; other site
309798001143	active site
309798001144	Uncharacterized conserved protein [Function unknown]; Region: COG1801
309798001145	sensory histidine kinase AtoS; Provisional; Region: PRK11360
309798001146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
309798001147	dimer interface [polypeptide binding]; other site
309798001148	phosphorylation site [posttranslational modification]
309798001149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798001150	ATP binding site [chemical binding]; other site
309798001151	Mg2+ binding site [ion binding]; other site
309798001152	G-X-G motif; other site
309798001153	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
309798001154	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
309798001155	YvrJ protein family; Region: YvrJ; pfam12841
309798001156	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
309798001157	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
309798001158	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
309798001159	active site
309798001160	catalytic residues [active]
309798001161	metal binding site [ion binding]; metal-binding site
309798001162	homodimer binding site [polypeptide binding]; other site
309798001163	O-Antigen ligase; Region: Wzy_C; pfam04932
309798001164	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
309798001165	Methyltransferase domain; Region: Methyltransf_26; pfam13659
309798001166	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
309798001167	Predicted methyltransferases [General function prediction only]; Region: COG0313
309798001168	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
309798001169	putative SAM binding site [chemical binding]; other site
309798001170	putative homodimer interface [polypeptide binding]; other site
309798001171	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
309798001172	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
309798001173	GTP binding site; other site
309798001174	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
309798001175	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
309798001176	putative dimer interface [polypeptide binding]; other site
309798001177	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
309798001178	MviN-like protein; Region: MVIN; pfam03023
309798001179	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
309798001180	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
309798001181	putative ADP-binding pocket [chemical binding]; other site
309798001182	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
309798001183	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
309798001184	active site
309798001185	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
309798001186	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
309798001187	putative ADP-binding pocket [chemical binding]; other site
309798001188	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
309798001189	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
309798001190	putative ADP-binding pocket [chemical binding]; other site
309798001191	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
309798001192	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
309798001193	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
309798001194	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
309798001195	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
309798001196	NAD binding site [chemical binding]; other site
309798001197	putative substrate binding site 2 [chemical binding]; other site
309798001198	putative substrate binding site 1 [chemical binding]; other site
309798001199	active site
309798001200	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
309798001201	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
309798001202	active site
309798001203	UDP-galactopyranose mutase; Region: GLF; pfam03275
309798001204	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
309798001205	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
309798001206	UDP-galactopyranose mutase; Region: GLF; pfam03275
309798001207	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
309798001208	active site
309798001209	multimer interface [polypeptide binding]; other site
309798001210	hypothetical protein; Provisional; Region: PRK08609
309798001211	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
309798001212	active site
309798001213	primer binding site [nucleotide binding]; other site
309798001214	NTP  binding site [chemical binding]; other site
309798001215	metal binding triad [ion binding]; metal-binding site
309798001216	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
309798001217	active site
309798001218	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
309798001219	catalytic core [active]
309798001220	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
309798001221	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
309798001222	putative active site [active]
309798001223	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798001224	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
309798001225	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
309798001226	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798001227	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798001228	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798001229	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798001230	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
309798001231	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
309798001232	HIGH motif; other site
309798001233	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
309798001234	active site
309798001235	KMSKS motif; other site
309798001236	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
309798001237	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
309798001238	motif 1; other site
309798001239	active site
309798001240	motif 2; other site
309798001241	motif 3; other site
309798001242	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
309798001243	DHHA1 domain; Region: DHHA1; pfam02272
309798001244	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
309798001245	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
309798001246	active site
309798001247	NTP binding site [chemical binding]; other site
309798001248	metal binding triad [ion binding]; metal-binding site
309798001249	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
309798001250	23S rRNA interface [nucleotide binding]; other site
309798001251	L3 interface [polypeptide binding]; other site
309798001252	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
309798001253	Right handed beta helix region; Region: Beta_helix; pfam13229
309798001254	Bacterial Ig-like domain; Region: Big_5; pfam13205
309798001255	Bacterial Ig-like domain; Region: Big_5; pfam13205
309798001256	Bacterial Ig-like domain; Region: Big_5; pfam13205
309798001257	S-layer homology domain; Region: SLH; pfam00395
309798001258	S-layer homology domain; Region: SLH; pfam00395
309798001259	S-layer homology domain; Region: SLH; pfam00395
309798001260	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
309798001261	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
309798001262	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
309798001263	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
309798001264	Zn binding site [ion binding]; other site
309798001265	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
309798001266	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
309798001267	substrate binding site; other site
309798001268	tetramer interface; other site
309798001269	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
309798001270	nucleoside/Zn binding site; other site
309798001271	dimer interface [polypeptide binding]; other site
309798001272	catalytic motif [active]
309798001273	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
309798001274	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798001275	Walker A motif; other site
309798001276	ATP binding site [chemical binding]; other site
309798001277	Walker B motif; other site
309798001278	arginine finger; other site
309798001279	recombination protein RecR; Reviewed; Region: recR; PRK00076
309798001280	RecR protein; Region: RecR; pfam02132
309798001281	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
309798001282	putative active site [active]
309798001283	putative metal-binding site [ion binding]; other site
309798001284	tetramer interface [polypeptide binding]; other site
309798001285	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
309798001286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798001287	Walker A motif; other site
309798001288	ATP binding site [chemical binding]; other site
309798001289	Walker B motif; other site
309798001290	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
309798001291	RxxxH motif; other site
309798001292	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
309798001293	thymidylate kinase; Validated; Region: tmk; PRK00698
309798001294	TMP-binding site; other site
309798001295	ATP-binding site [chemical binding]; other site
309798001296	Protein of unknown function (DUF970); Region: DUF970; cl17525
309798001297	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
309798001298	DNA polymerase III subunit delta'; Validated; Region: PRK08485
309798001299	PSP1 C-terminal conserved region; Region: PSP1; cl00770
309798001300	Protein of unknown function (DUF552); Region: DUF552; pfam04472
309798001301	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
309798001302	SmpB-tmRNA interface; other site
309798001303	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
309798001304	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
309798001305	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
309798001306	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
309798001307	Coenzyme A binding pocket [chemical binding]; other site
309798001308	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
309798001309	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798001310	putative active site [active]
309798001311	putative metal binding site [ion binding]; other site
309798001312	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
309798001313	EamA-like transporter family; Region: EamA; pfam00892
309798001314	EamA-like transporter family; Region: EamA; pfam00892
309798001315	Rubrerythrin [Energy production and conversion]; Region: COG1592
309798001316	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
309798001317	binuclear metal center [ion binding]; other site
309798001318	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
309798001319	iron binding site [ion binding]; other site
309798001320	Protein of unknown function DUF72; Region: DUF72; pfam01904
309798001321	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
309798001322	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
309798001323	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
309798001324	Peptidase family M23; Region: Peptidase_M23; pfam01551
309798001325	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
309798001326	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
309798001327	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
309798001328	PhoH-like protein; Region: PhoH; pfam02562
309798001329	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
309798001330	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798001331	Zn2+ binding site [ion binding]; other site
309798001332	Mg2+ binding site [ion binding]; other site
309798001333	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
309798001334	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
309798001335	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
309798001336	active site
309798001337	catalytic motif [active]
309798001338	Zn binding site [ion binding]; other site
309798001339	GTPase Era; Reviewed; Region: era; PRK00089
309798001340	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
309798001341	G1 box; other site
309798001342	GTP/Mg2+ binding site [chemical binding]; other site
309798001343	Switch I region; other site
309798001344	G2 box; other site
309798001345	Switch II region; other site
309798001346	G3 box; other site
309798001347	G4 box; other site
309798001348	G5 box; other site
309798001349	KH domain; Region: KH_2; pfam07650
309798001350	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
309798001351	Active_site [active]
309798001352	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
309798001353	intersubunit interface [polypeptide binding]; other site
309798001354	active site
309798001355	catalytic residue [active]
309798001356	Recombination protein O N terminal; Region: RecO_N; pfam11967
309798001357	DNA repair protein RecO; Region: reco; TIGR00613
309798001358	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
309798001359	motif 1; other site
309798001360	dimer interface [polypeptide binding]; other site
309798001361	active site
309798001362	motif 2; other site
309798001363	motif 3; other site
309798001364	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
309798001365	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
309798001366	pyruvate phosphate dikinase; Provisional; Region: PRK09279
309798001367	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
309798001368	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
309798001369	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
309798001370	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
309798001371	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
309798001372	active site
309798001373	(T/H)XGH motif; other site
309798001374	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
309798001375	propionate/acetate kinase; Provisional; Region: PRK12379
309798001376	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
309798001377	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
309798001378	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
309798001379	Phosphopantetheine attachment site; Region: PP-binding; cl09936
309798001380	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
309798001381	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798001382	FeS/SAM binding site; other site
309798001383	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
309798001384	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
309798001385	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
309798001386	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
309798001387	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
309798001388	active site
309798001389	Protein of unknown function (DUF996); Region: DUF996; pfam06195
309798001390	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
309798001391	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
309798001392	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
309798001393	active site
309798001394	dimer interface [polypeptide binding]; other site
309798001395	effector binding site; other site
309798001396	TSCPD domain; Region: TSCPD; pfam12637
309798001397	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
309798001398	Yqey-like protein; Region: YqeY; pfam09424
309798001399	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
309798001400	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
309798001401	active site
309798001402	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
309798001403	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
309798001404	CoA binding domain; Region: CoA_binding; pfam02629
309798001405	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
309798001406	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
309798001407	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
309798001408	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798001409	active site
309798001410	metal binding site [ion binding]; metal-binding site
309798001411	DNA binding site [nucleotide binding]
309798001412	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
309798001413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798001414	Walker A/P-loop; other site
309798001415	ATP binding site [chemical binding]; other site
309798001416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798001417	ABC transporter signature motif; other site
309798001418	Walker B; other site
309798001419	D-loop; other site
309798001420	H-loop/switch region; other site
309798001421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
309798001422	HerA helicase [Replication, recombination, and repair]; Region: COG0433
309798001423	HerA helicase [Replication, recombination, and repair]; Region: COG0433
309798001424	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
309798001425	active site
309798001426	dimerization interface [polypeptide binding]; other site
309798001427	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
309798001428	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
309798001429	active site
309798001430	HIGH motif; other site
309798001431	nucleotide binding site [chemical binding]; other site
309798001432	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
309798001433	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
309798001434	active site
309798001435	KMSKS motif; other site
309798001436	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
309798001437	tRNA binding surface [nucleotide binding]; other site
309798001438	anticodon binding site; other site
309798001439	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
309798001440	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
309798001441	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
309798001442	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
309798001443	AMMECR1; Region: AMMECR1; pfam01871
309798001444	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
309798001445	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798001446	FeS/SAM binding site; other site
309798001447	rod shape-determining protein MreB; Provisional; Region: PRK13927
309798001448	MreB and similar proteins; Region: MreB_like; cd10225
309798001449	nucleotide binding site [chemical binding]; other site
309798001450	Mg binding site [ion binding]; other site
309798001451	putative protofilament interaction site [polypeptide binding]; other site
309798001452	RodZ interaction site [polypeptide binding]; other site
309798001453	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
309798001454	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
309798001455	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
309798001456	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
309798001457	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
309798001458	Switch I; other site
309798001459	Switch II; other site
309798001460	Septum formation topological specificity factor MinE; Region: MinE; cl00538
309798001461	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
309798001462	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
309798001463	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
309798001464	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
309798001465	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
309798001466	RNA binding surface [nucleotide binding]; other site
309798001467	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
309798001468	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
309798001469	homodimer interface [polypeptide binding]; other site
309798001470	metal binding site [ion binding]; metal-binding site
309798001471	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
309798001472	homodimer interface [polypeptide binding]; other site
309798001473	active site
309798001474	putative chemical substrate binding site [chemical binding]; other site
309798001475	metal binding site [ion binding]; metal-binding site
309798001476	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
309798001477	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
309798001478	Oligomerisation domain; Region: Oligomerisation; pfam02410
309798001479	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
309798001480	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
309798001481	active site
309798001482	(T/H)XGH motif; other site
309798001483	GTPase CgtA; Reviewed; Region: obgE; PRK12297
309798001484	GTP1/OBG; Region: GTP1_OBG; pfam01018
309798001485	Obg GTPase; Region: Obg; cd01898
309798001486	G1 box; other site
309798001487	GTP/Mg2+ binding site [chemical binding]; other site
309798001488	Switch I region; other site
309798001489	G2 box; other site
309798001490	G3 box; other site
309798001491	Switch II region; other site
309798001492	G4 box; other site
309798001493	G5 box; other site
309798001494	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
309798001495	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
309798001496	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
309798001497	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
309798001498	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798001499	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
309798001500	C-terminal peptidase (prc); Region: prc; TIGR00225
309798001501	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
309798001502	protein binding site [polypeptide binding]; other site
309798001503	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
309798001504	Catalytic dyad [active]
309798001505	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
309798001506	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
309798001507	substrate binding pocket [chemical binding]; other site
309798001508	membrane-bound complex binding site; other site
309798001509	hinge residues; other site
309798001510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798001511	dimer interface [polypeptide binding]; other site
309798001512	conserved gate region; other site
309798001513	putative PBP binding loops; other site
309798001514	ABC-ATPase subunit interface; other site
309798001515	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
309798001516	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
309798001517	Walker A/P-loop; other site
309798001518	ATP binding site [chemical binding]; other site
309798001519	Q-loop/lid; other site
309798001520	ABC transporter signature motif; other site
309798001521	Walker B; other site
309798001522	D-loop; other site
309798001523	H-loop/switch region; other site
309798001524	Protein of unknown function (DUF1602); Region: DUF1602; pfam07673
309798001525	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
309798001526	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
309798001527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798001528	homodimer interface [polypeptide binding]; other site
309798001529	catalytic residue [active]
309798001530	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
309798001531	classical (c) SDRs; Region: SDR_c; cd05233
309798001532	NAD(P) binding site [chemical binding]; other site
309798001533	active site
309798001534	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
309798001535	PhoU domain; Region: PhoU; pfam01895
309798001536	PhoU domain; Region: PhoU; pfam01895
309798001537	PAS domain; Region: PAS; smart00091
309798001538	PAS fold; Region: PAS_4; pfam08448
309798001539	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
309798001540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
309798001541	phosphorylation site [posttranslational modification]
309798001542	dimer interface [polypeptide binding]; other site
309798001543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798001544	ATP binding site [chemical binding]; other site
309798001545	G-X-G motif; other site
309798001546	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
309798001547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
309798001548	active site
309798001549	phosphorylation site [posttranslational modification]
309798001550	intermolecular recognition site; other site
309798001551	dimerization interface [polypeptide binding]; other site
309798001552	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
309798001553	DNA binding site [nucleotide binding]
309798001554	NAD-dependent deacetylase; Provisional; Region: PRK00481
309798001555	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
309798001556	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
309798001557	Putative methyltransferase; Region: Methyltransf_4; cl17290
309798001558	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
309798001559	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
309798001560	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
309798001561	active site
309798001562	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
309798001563	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
309798001564	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
309798001565	ATP synthase subunit C; Region: ATP-synt_C; cl00466
309798001566	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
309798001567	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
309798001568	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
309798001569	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
309798001570	Walker A motif; other site
309798001571	ATP binding site [chemical binding]; other site
309798001572	Walker B motif; other site
309798001573	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
309798001574	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365
309798001575	core domain interface [polypeptide binding]; other site
309798001576	delta subunit interface [polypeptide binding]; other site
309798001577	epsilon subunit interface [polypeptide binding]; other site
309798001578	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
309798001579	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
309798001580	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
309798001581	alpha subunit interaction interface [polypeptide binding]; other site
309798001582	Walker A motif; other site
309798001583	ATP binding site [chemical binding]; other site
309798001584	Walker B motif; other site
309798001585	inhibitor binding site; inhibition site
309798001586	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
309798001587	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
309798001588	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448
309798001589	gamma subunit interface [polypeptide binding]; other site
309798001590	epsilon subunit interface [polypeptide binding]; other site
309798001591	LBP interface [polypeptide binding]; other site
309798001592	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
309798001593	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
309798001594	dimer interface [polypeptide binding]; other site
309798001595	putative functional site; other site
309798001596	putative MPT binding site; other site
309798001597	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
309798001598	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
309798001599	dimer interface [polypeptide binding]; other site
309798001600	putative functional site; other site
309798001601	putative MPT binding site; other site
309798001602	PBP superfamily domain; Region: PBP_like; pfam12727
309798001603	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
309798001604	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798001605	FeS/SAM binding site; other site
309798001606	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
309798001607	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
309798001608	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
309798001609	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
309798001610	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
309798001611	trimer interface [polypeptide binding]; other site
309798001612	putative active site [active]
309798001613	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
309798001614	dimer interface [polypeptide binding]; other site
309798001615	putative active site [active]
309798001616	trimer interface [polypeptide binding]; other site
309798001617	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
309798001618	MPT binding site; other site
309798001619	trimer interface [polypeptide binding]; other site
309798001620	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
309798001621	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
309798001622	nucleotide binding site [chemical binding]; other site
309798001623	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
309798001624	Malic enzyme, N-terminal domain; Region: malic; pfam00390
309798001625	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
309798001626	NAD(P) binding pocket [chemical binding]; other site
309798001627	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
309798001628	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
309798001629	active site
309798001630	metal-binding site
309798001631	Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174
309798001632	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
309798001633	active site
309798001634	metal binding site [ion binding]; metal-binding site
309798001635	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
309798001636	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
309798001637	N-acetyl-D-glucosamine binding site [chemical binding]; other site
309798001638	catalytic residue [active]
309798001639	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
309798001640	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
309798001641	active site
309798001642	metal binding site [ion binding]; metal-binding site
309798001643	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
309798001644	EDD domain protein, DegV family; Region: DegV; TIGR00762
309798001645	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
309798001646	EDD domain protein, DegV family; Region: DegV; TIGR00762
309798001647	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
309798001648	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
309798001649	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
309798001650	Dimer interface [polypeptide binding]; other site
309798001651	anticodon binding site; other site
309798001652	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
309798001653	homodimer interface [polypeptide binding]; other site
309798001654	motif 1; other site
309798001655	motif 2; other site
309798001656	active site
309798001657	motif 3; other site
309798001658	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
309798001659	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
309798001660	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798001661	active site
309798001662	metal binding site [ion binding]; metal-binding site
309798001663	homotetramer interface [polypeptide binding]; other site
309798001664	L-asparaginase II; Region: Asparaginase_II; pfam06089
309798001665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798001666	Radical SAM superfamily; Region: Radical_SAM; pfam04055
309798001667	FeS/SAM binding site; other site
309798001668	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
309798001669	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
309798001670	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
309798001671	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
309798001672	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
309798001673	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
309798001674	23S rRNA binding site [nucleotide binding]; other site
309798001675	L21 binding site [polypeptide binding]; other site
309798001676	L13 binding site [polypeptide binding]; other site
309798001677	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
309798001678	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
309798001679	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
309798001680	dimer interface [polypeptide binding]; other site
309798001681	motif 1; other site
309798001682	active site
309798001683	motif 2; other site
309798001684	motif 3; other site
309798001685	Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072
309798001686	B3/4 domain; Region: B3_4; pfam03483
309798001687	tRNA synthetase B5 domain; Region: B5; cl08394
309798001688	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
309798001689	dimer interface [polypeptide binding]; other site
309798001690	motif 1; other site
309798001691	motif 3; other site
309798001692	motif 2; other site
309798001693	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
309798001694	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
309798001695	MutS domain III; Region: MutS_III; pfam05192
309798001696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798001697	Walker A/P-loop; other site
309798001698	ATP binding site [chemical binding]; other site
309798001699	Q-loop/lid; other site
309798001700	ABC transporter signature motif; other site
309798001701	Walker B; other site
309798001702	D-loop; other site
309798001703	H-loop/switch region; other site
309798001704	Smr domain; Region: Smr; pfam01713
309798001705	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
309798001706	tetramerization interface [polypeptide binding]; other site
309798001707	active site
309798001708	pantoate--beta-alanine ligase; Region: panC; TIGR00018
309798001709	Pantoate-beta-alanine ligase; Region: PanC; cd00560
309798001710	active site
309798001711	ATP-binding site [chemical binding]; other site
309798001712	pantoate-binding site; other site
309798001713	HXXH motif; other site
309798001714	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
309798001715	oligomerization interface [polypeptide binding]; other site
309798001716	active site
309798001717	metal binding site [ion binding]; metal-binding site
309798001718	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
309798001719	NurA nuclease; Region: NurA; smart00933
309798001720	AAA-like domain; Region: AAA_10; pfam12846
309798001721	Domain of unknown function DUF87; Region: DUF87; pfam01935
309798001722	Zonular occludens toxin (Zot); Region: Zot; cl17485
309798001723	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
309798001724	DNA methylase; Region: N6_N4_Mtase; pfam01555
309798001725	DNA methylase; Region: N6_N4_Mtase; pfam01555
309798001726	DEAD-like helicases superfamily; Region: DEXDc; smart00487
309798001727	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
309798001728	ATP binding site [chemical binding]; other site
309798001729	putative Mg++ binding site [ion binding]; other site
309798001730	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
309798001731	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
309798001732	Putative esterase; Region: Esterase; pfam00756
309798001733	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
309798001734	Uncharacterized conserved protein [Function unknown]; Region: COG3586
309798001735	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
309798001736	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
309798001737	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
309798001738	dimer interface [polypeptide binding]; other site
309798001739	ssDNA binding site [nucleotide binding]; other site
309798001740	tetramer (dimer of dimers) interface [polypeptide binding]; other site
309798001741	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
309798001742	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
309798001743	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
309798001744	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
309798001745	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
309798001746	replicative DNA helicase; Region: DnaB; TIGR00665
309798001747	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
309798001748	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
309798001749	Walker A motif; other site
309798001750	ATP binding site [chemical binding]; other site
309798001751	Walker B motif; other site
309798001752	DNA binding loops [nucleotide binding]
309798001753	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
309798001754	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
309798001755	HIGH motif; other site
309798001756	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
309798001757	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
309798001758	active site
309798001759	KMSKS motif; other site
309798001760	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
309798001761	tRNA binding surface [nucleotide binding]; other site
309798001762	SLBB domain; Region: SLBB; pfam10531
309798001763	comEA protein; Region: comE; TIGR01259
309798001764	Helix-hairpin-helix motif; Region: HHH; pfam00633
309798001765	Competence protein; Region: Competence; cl00471
309798001766	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
309798001767	Transcriptional regulator [Transcription]; Region: LytR; COG1316
309798001768	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
309798001769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798001770	Mg2+ binding site [ion binding]; other site
309798001771	G-X-G motif; other site
309798001772	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
309798001773	anchoring element; other site
309798001774	dimer interface [polypeptide binding]; other site
309798001775	ATP binding site [chemical binding]; other site
309798001776	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
309798001777	active site
309798001778	putative metal-binding site [ion binding]; other site
309798001779	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
309798001780	DNA gyrase subunit A; Validated; Region: PRK05560
309798001781	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
309798001782	CAP-like domain; other site
309798001783	active site
309798001784	primary dimer interface [polypeptide binding]; other site
309798001785	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
309798001786	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
309798001787	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
309798001788	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
309798001789	hypothetical protein; Reviewed; Region: PRK09588
309798001790	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
309798001791	Glycoprotease family; Region: Peptidase_M22; pfam00814
309798001792	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
309798001793	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
309798001794	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
309798001795	Coenzyme A binding pocket [chemical binding]; other site
309798001796	UGMP family protein; Validated; Region: PRK09604
309798001797	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
309798001798	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
309798001799	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
309798001800	oligomerisation interface [polypeptide binding]; other site
309798001801	mobile loop; other site
309798001802	roof hairpin; other site
309798001803	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
309798001804	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
309798001805	ring oligomerisation interface [polypeptide binding]; other site
309798001806	ATP/Mg binding site [chemical binding]; other site
309798001807	stacking interactions; other site
309798001808	hinge regions; other site
309798001809	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
309798001810	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798001811	dimer interface [polypeptide binding]; other site
309798001812	ABC-ATPase subunit interface; other site
309798001813	putative PBP binding loops; other site
309798001814	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
309798001815	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
309798001816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798001817	dimer interface [polypeptide binding]; other site
309798001818	conserved gate region; other site
309798001819	putative PBP binding loops; other site
309798001820	ABC-ATPase subunit interface; other site
309798001821	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
309798001822	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
309798001823	Walker A/P-loop; other site
309798001824	ATP binding site [chemical binding]; other site
309798001825	Q-loop/lid; other site
309798001826	ABC transporter signature motif; other site
309798001827	Walker B; other site
309798001828	D-loop; other site
309798001829	H-loop/switch region; other site
309798001830	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
309798001831	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
309798001832	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
309798001833	Walker A/P-loop; other site
309798001834	ATP binding site [chemical binding]; other site
309798001835	Q-loop/lid; other site
309798001836	ABC transporter signature motif; other site
309798001837	Walker B; other site
309798001838	D-loop; other site
309798001839	H-loop/switch region; other site
309798001840	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
309798001841	lipoyl synthase; Provisional; Region: PRK05481
309798001842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798001843	FeS/SAM binding site; other site
309798001844	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
309798001845	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
309798001846	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
309798001847	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
309798001848	active site
309798001849	HIGH motif; other site
309798001850	KMSK motif region; other site
309798001851	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
309798001852	tRNA binding surface [nucleotide binding]; other site
309798001853	anticodon binding site; other site
309798001854	CTP synthetase; Validated; Region: pyrG; PRK05380
309798001855	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
309798001856	Catalytic site [active]
309798001857	active site
309798001858	UTP binding site [chemical binding]; other site
309798001859	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
309798001860	active site
309798001861	putative oxyanion hole; other site
309798001862	catalytic triad [active]
309798001863	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
309798001864	acetylornithine aminotransferase; Provisional; Region: PRK02627
309798001865	inhibitor-cofactor binding pocket; inhibition site
309798001866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798001867	catalytic residue [active]
309798001868	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
309798001869	putative hydrophobic ligand binding site [chemical binding]; other site
309798001870	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
309798001871	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
309798001872	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
309798001873	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
309798001874	GDP-binding site [chemical binding]; other site
309798001875	ACT binding site; other site
309798001876	IMP binding site; other site
309798001877	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
309798001878	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
309798001879	homodimer interface [polypeptide binding]; other site
309798001880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798001881	catalytic residue [active]
309798001882	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
309798001883	V-type ATP synthase subunit I; Validated; Region: PRK05771
309798001884	V-type ATP synthase subunit K; Provisional; Region: PRK09621
309798001885	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
309798001886	V-type ATP synthase subunit A; Provisional; Region: PRK04192
309798001887	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
309798001888	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
309798001889	Walker A motif/ATP binding site; other site
309798001890	Walker B motif; other site
309798001891	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
309798001892	V-type ATP synthase subunit B; Provisional; Region: PRK04196
309798001893	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
309798001894	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
309798001895	Walker A motif homologous position; other site
309798001896	Walker B motif; other site
309798001897	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
309798001898	ATP synthase subunit D; Region: ATP-synt_D; cl00613
309798001899	6-phosphofructokinase; Provisional; Region: PRK03202
309798001900	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
309798001901	active site
309798001902	ADP/pyrophosphate binding site [chemical binding]; other site
309798001903	dimerization interface [polypeptide binding]; other site
309798001904	allosteric effector site; other site
309798001905	fructose-1,6-bisphosphate binding site; other site
309798001906	MraZ protein; Region: MraZ; pfam02381
309798001907	cell division protein MraZ; Reviewed; Region: PRK00326
309798001908	MraZ protein; Region: MraZ; pfam02381
309798001909	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
309798001910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798001911	S-adenosylmethionine binding site [chemical binding]; other site
309798001912	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
309798001913	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
309798001914	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
309798001915	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
309798001916	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
309798001917	putative catalytic motif [active]
309798001918	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
309798001919	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
309798001920	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
309798001921	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
309798001922	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
309798001923	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
309798001924	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
309798001925	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
309798001926	ATP-grasp domain; Region: ATP-grasp_4; cl17255
309798001927	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
309798001928	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
309798001929	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
309798001930	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
309798001931	Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091
309798001932	nucleotide binding site [chemical binding]; other site
309798001933	SulA interaction site; other site
309798001934	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
309798001935	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798001936	FeS/SAM binding site; other site
309798001937	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
309798001938	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
309798001939	active site
309798001940	HIGH motif; other site
309798001941	nucleotide binding site [chemical binding]; other site
309798001942	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
309798001943	active site
309798001944	KMSKS motif; other site
309798001945	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
309798001946	tRNA binding surface [nucleotide binding]; other site
309798001947	anticodon binding site; other site
309798001948	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
309798001949	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
309798001950	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
309798001951	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
309798001952	RNA binding surface [nucleotide binding]; other site
309798001953	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
309798001954	active site
309798001955	seryl-tRNA synthetase; Provisional; Region: PRK05431
309798001956	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
309798001957	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
309798001958	dimer interface [polypeptide binding]; other site
309798001959	active site
309798001960	motif 1; other site
309798001961	motif 2; other site
309798001962	motif 3; other site
309798001963	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
309798001964	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
309798001965	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
309798001966	substrate binding site [chemical binding]; other site
309798001967	ATP binding site [chemical binding]; other site
309798001968	Predicted methyltransferases [General function prediction only]; Region: COG1568
309798001969	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
309798001970	Uncharacterized conserved protein [Function unknown]; Region: COG0062
309798001971	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
309798001972	putative substrate binding site [chemical binding]; other site
309798001973	putative ATP binding site [chemical binding]; other site
309798001974	DNA primase; Validated; Region: dnaG; PRK05667
309798001975	CHC2 zinc finger; Region: zf-CHC2; pfam01807
309798001976	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
309798001977	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
309798001978	active site
309798001979	metal binding site [ion binding]; metal-binding site
309798001980	interdomain interaction site; other site
309798001981	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
309798001982	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
309798001983	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
309798001984	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
309798001985	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
309798001986	DNA binding residues [nucleotide binding]
309798001987	excinuclease ABC subunit B; Provisional; Region: PRK05298
309798001988	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
309798001989	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
309798001990	ATP-binding site [chemical binding]; other site
309798001991	ATP binding site [chemical binding]; other site
309798001992	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
309798001993	nucleotide binding region [chemical binding]; other site
309798001994	ATP-binding site [chemical binding]; other site
309798001995	Ultra-violet resistance protein B; Region: UvrB; pfam12344
309798001996	UvrB/uvrC motif; Region: UVR; pfam02151
309798001997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
309798001998	Signal recognition particle GTPase [Intracellular trafficking and secretion]; Region: Ffh; COG0541
309798001999	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
309798002000	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
309798002001	P loop; other site
309798002002	GTP binding site [chemical binding]; other site
309798002003	Signal peptide binding domain; Region: SRP_SPB; pfam02978
309798002004	ribosomal protein S16; Region: S16; TIGR00002
309798002005	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
309798002006	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
309798002007	RimM N-terminal domain; Region: RimM; pfam01782
309798002008	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
309798002009	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
309798002010	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
309798002011	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
309798002012	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
309798002013	Catalytic site [active]
309798002014	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
309798002015	RNA/DNA hybrid binding site [nucleotide binding]; other site
309798002016	active site
309798002017	hypothetical protein; Reviewed; Region: PRK12497
309798002018	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
309798002019	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
309798002020	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
309798002021	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
309798002022	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
309798002023	DNA protecting protein DprA; Region: dprA; TIGR00732
309798002024	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
309798002025	Glucose inhibited division protein A; Region: GIDA; pfam01134
309798002026	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
309798002027	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
309798002028	active site
309798002029	DNA binding site [nucleotide binding]
309798002030	Int/Topo IB signature motif; other site
309798002031	N-ethylammeline chlorohydrolase; Provisional; Region: PRK08393
309798002032	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
309798002033	active site
309798002034	putative substrate binding pocket [chemical binding]; other site
309798002035	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
309798002036	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
309798002037	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
309798002038	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
309798002039	dimer interface [polypeptide binding]; other site
309798002040	active site
309798002041	glycine-pyridoxal phosphate binding site [chemical binding]; other site
309798002042	folate binding site [chemical binding]; other site
309798002043	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798002044	active site
309798002045	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
309798002046	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
309798002047	Mg++ binding site [ion binding]; other site
309798002048	putative catalytic motif [active]
309798002049	substrate binding site [chemical binding]; other site
309798002050	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
309798002051	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
309798002052	active site
309798002053	homodimer interface [polypeptide binding]; other site
309798002054	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
309798002055	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
309798002056	hinge; other site
309798002057	active site
309798002058	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
309798002059	5'-3' exonuclease; Region: 53EXOc; smart00475
309798002060	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
309798002061	active site
309798002062	metal binding site 1 [ion binding]; metal-binding site
309798002063	putative 5' ssDNA interaction site; other site
309798002064	metal binding site 3; metal-binding site
309798002065	metal binding site 2 [ion binding]; metal-binding site
309798002066	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
309798002067	putative DNA binding site [nucleotide binding]; other site
309798002068	putative metal binding site [ion binding]; other site
309798002069	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
309798002070	active site
309798002071	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
309798002072	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
309798002073	DNA binding site [nucleotide binding]
309798002074	active site
309798002075	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
309798002076	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
309798002077	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
309798002078	MarR family; Region: MarR_2; cl17246
309798002079	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
309798002080	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
309798002081	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
309798002082	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
309798002083	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
309798002084	Phosphoglycerate kinase; Region: PGK; pfam00162
309798002085	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
309798002086	substrate binding site [chemical binding]; other site
309798002087	hinge regions; other site
309798002088	ADP binding site [chemical binding]; other site
309798002089	catalytic site [active]
309798002090	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
309798002091	triosephosphate isomerase; Provisional; Region: PRK14565
309798002092	substrate binding site [chemical binding]; other site
309798002093	dimer interface [polypeptide binding]; other site
309798002094	catalytic triad [active]
309798002095	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
309798002096	16S/18S rRNA binding site [nucleotide binding]; other site
309798002097	S13e-L30e interaction site [polypeptide binding]; other site
309798002098	25S rRNA binding site [nucleotide binding]; other site
309798002099	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
309798002100	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
309798002101	RNase E interface [polypeptide binding]; other site
309798002102	trimer interface [polypeptide binding]; other site
309798002103	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
309798002104	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
309798002105	RNase E interface [polypeptide binding]; other site
309798002106	trimer interface [polypeptide binding]; other site
309798002107	active site
309798002108	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
309798002109	putative nucleic acid binding region [nucleotide binding]; other site
309798002110	G-X-X-G motif; other site
309798002111	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
309798002112	RNA binding site [nucleotide binding]; other site
309798002113	domain interface; other site
309798002114	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
309798002115	Fe-S cluster binding site [ion binding]; other site
309798002116	active site
309798002117	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
309798002118	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
309798002119	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
309798002120	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
309798002121	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
309798002122	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
309798002123	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
309798002124	rRNA interaction site [nucleotide binding]; other site
309798002125	S8 interaction site; other site
309798002126	putative laminin-1 binding site; other site
309798002127	elongation factor Ts; Reviewed; Region: tsf; PRK12332
309798002128	UBA/TS-N domain; Region: UBA; pfam00627
309798002129	Elongation factor TS; Region: EF_TS; pfam00889
309798002130	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
309798002131	nucleotide binding site [chemical binding]; other site
309798002132	substrate binding site [chemical binding]; other site
309798002133	ribosome recycling factor; Reviewed; Region: frr; PRK00083
309798002134	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
309798002135	hinge region; other site
309798002136	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
309798002137	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
309798002138	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
309798002139	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
309798002140	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
309798002141	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
309798002142	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
309798002143	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
309798002144	active site
309798002145	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
309798002146	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
309798002147	putative substrate binding region [chemical binding]; other site
309798002148	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
309798002149	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
309798002150	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
309798002151	prolyl-tRNA synthetase; Provisional; Region: PRK09194
309798002152	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
309798002153	dimer interface [polypeptide binding]; other site
309798002154	motif 1; other site
309798002155	active site
309798002156	motif 2; other site
309798002157	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
309798002158	putative deacylase active site [active]
309798002159	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
309798002160	active site
309798002161	motif 3; other site
309798002162	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
309798002163	anticodon binding site; other site
309798002164	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
309798002165	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
309798002166	Ligand binding site; other site
309798002167	Putative Catalytic site; other site
309798002168	DXD motif; other site
309798002169	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
309798002170	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
309798002171	LexA repressor; Validated; Region: PRK00215
309798002172	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
309798002173	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
309798002174	Catalytic site [active]
309798002175	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
309798002176	dimerization interface [polypeptide binding]; other site
309798002177	ATP binding site [chemical binding]; other site
309798002178	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
309798002179	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
309798002180	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
309798002181	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
309798002182	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
309798002183	trimer interface [polypeptide binding]; other site
309798002184	active site
309798002185	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
309798002186	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
309798002187	active site
309798002188	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
309798002189	active site
309798002190	substrate binding site [chemical binding]; other site
309798002191	CoA binding site [chemical binding]; other site
309798002192	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
309798002193	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
309798002194	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798002195	active site
309798002196	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
309798002197	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
309798002198	5S rRNA interface [nucleotide binding]; other site
309798002199	CTC domain interface [polypeptide binding]; other site
309798002200	L16 interface [polypeptide binding]; other site
309798002201	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
309798002202	putative active site [active]
309798002203	catalytic residue [active]
309798002204	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
309798002205	DEAD-like helicases superfamily; Region: DEXDc; smart00487
309798002206	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
309798002207	ATP binding site [chemical binding]; other site
309798002208	putative Mg++ binding site [ion binding]; other site
309798002209	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
309798002210	nucleotide binding region [chemical binding]; other site
309798002211	ATP-binding site [chemical binding]; other site
309798002212	TRCF domain; Region: TRCF; cl04088
309798002213	histidyl-tRNA synthetase; Region: hisS; TIGR00442
309798002214	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
309798002215	dimer interface [polypeptide binding]; other site
309798002216	motif 1; other site
309798002217	active site
309798002218	motif 2; other site
309798002219	motif 3; other site
309798002220	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
309798002221	anticodon binding site; other site
309798002222	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
309798002223	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
309798002224	dimer interface [polypeptide binding]; other site
309798002225	anticodon binding site; other site
309798002226	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
309798002227	homodimer interface [polypeptide binding]; other site
309798002228	motif 1; other site
309798002229	active site
309798002230	motif 2; other site
309798002231	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
309798002232	active site
309798002233	motif 3; other site
309798002234	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
309798002235	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
309798002236	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
309798002237	DNA binding residues [nucleotide binding]
309798002238	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
309798002239	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
309798002240	Type II/IV secretion system protein; Region: T2SE; pfam00437
309798002241	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
309798002242	Walker A motif; other site
309798002243	ATP binding site [chemical binding]; other site
309798002244	Walker B motif; other site
309798002245	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
309798002246	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
309798002247	Walker A motif; other site
309798002248	ATP binding site [chemical binding]; other site
309798002249	Walker B motif; other site
309798002250	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
309798002251	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
309798002252	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
309798002253	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
309798002254	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
309798002255	active site
309798002256	elongation factor P; Validated; Region: PRK00529
309798002257	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
309798002258	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
309798002259	RNA binding site [nucleotide binding]; other site
309798002260	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
309798002261	RNA binding site [nucleotide binding]; other site
309798002262	NusB family; Region: NusB; pfam01029
309798002263	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
309798002264	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
309798002265	TPP-binding site; other site
309798002266	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
309798002267	PYR/PP interface [polypeptide binding]; other site
309798002268	dimer interface [polypeptide binding]; other site
309798002269	TPP binding site [chemical binding]; other site
309798002270	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
309798002271	ATP-NAD kinase; Region: NAD_kinase; pfam01513
309798002272	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
309798002273	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
309798002274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798002275	Walker A/P-loop; other site
309798002276	ATP binding site [chemical binding]; other site
309798002277	Q-loop/lid; other site
309798002278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798002279	ABC transporter signature motif; other site
309798002280	Walker B; other site
309798002281	D-loop; other site
309798002282	H-loop/switch region; other site
309798002283	butyrate kinase; Provisional; Region: PRK03011
309798002284	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
309798002285	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
309798002286	nucleotide binding site [chemical binding]; other site
309798002287	Acetokinase family; Region: Acetate_kinase; cl17229
309798002288	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
309798002289	active site
309798002290	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
309798002291	Ferredoxin [Energy production and conversion]; Region: COG1146
309798002292	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
309798002293	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
309798002294	dimer interface [polypeptide binding]; other site
309798002295	PYR/PP interface [polypeptide binding]; other site
309798002296	TPP binding site [chemical binding]; other site
309798002297	substrate binding site [chemical binding]; other site
309798002298	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
309798002299	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
309798002300	TPP-binding site [chemical binding]; other site
309798002301	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
309798002302	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
309798002303	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
309798002304	dimer interface [polypeptide binding]; other site
309798002305	ADP-ribose binding site [chemical binding]; other site
309798002306	active site
309798002307	nudix motif; other site
309798002308	metal binding site [ion binding]; metal-binding site
309798002309	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
309798002310	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
309798002311	active site
309798002312	DNA binding site [nucleotide binding]
309798002313	Int/Topo IB signature motif; other site
309798002314	phosphopentomutase; Provisional; Region: PRK05362
309798002315	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
309798002316	purine nucleoside phosphorylase; Provisional; Region: PRK08202
309798002317	Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213
309798002318	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
309798002319	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
309798002320	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
309798002321	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
309798002322	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
309798002323	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
309798002324	active site
309798002325	NTP binding site [chemical binding]; other site
309798002326	metal binding triad [ion binding]; metal-binding site
309798002327	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
309798002328	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
309798002329	active site
309798002330	HIGH motif; other site
309798002331	dimer interface [polypeptide binding]; other site
309798002332	KMSKS motif; other site
309798002333	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
309798002334	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
309798002335	CMP-binding site; other site
309798002336	The sites determining sugar specificity; other site
309798002337	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
309798002338	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
309798002339	putative acyl-acceptor binding pocket; other site
309798002340	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
309798002341	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
309798002342	CMP-binding site; other site
309798002343	The sites determining sugar specificity; other site
309798002344	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
309798002345	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
309798002346	putative acyl-acceptor binding pocket; other site
309798002347	LytB protein; Region: LYTB; cl00507
309798002348	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
309798002349	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
309798002350	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
309798002351	G1 box; other site
309798002352	GTP/Mg2+ binding site [chemical binding]; other site
309798002353	Switch I region; other site
309798002354	G2 box; other site
309798002355	Switch II region; other site
309798002356	G3 box; other site
309798002357	G4 box; other site
309798002358	G5 box; other site
309798002359	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
309798002360	G1 box; other site
309798002361	GTP/Mg2+ binding site [chemical binding]; other site
309798002362	G2 box; other site
309798002363	Switch I region; other site
309798002364	G3 box; other site
309798002365	Switch II region; other site
309798002366	G4 box; other site
309798002367	G5 box; other site
309798002368	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
309798002369	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
309798002370	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
309798002371	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
309798002372	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
309798002373	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
309798002374	active site
309798002375	metal binding site [ion binding]; metal-binding site
309798002376	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
309798002377	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
309798002378	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
309798002379	active site
309798002380	metal binding site [ion binding]; metal-binding site
309798002381	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
309798002382	NAD synthetase; Provisional; Region: PRK13981
309798002383	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
309798002384	multimer interface [polypeptide binding]; other site
309798002385	active site
309798002386	catalytic triad [active]
309798002387	protein interface 1 [polypeptide binding]; other site
309798002388	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
309798002389	homodimer interface [polypeptide binding]; other site
309798002390	NAD binding pocket [chemical binding]; other site
309798002391	ATP binding pocket [chemical binding]; other site
309798002392	Mg binding site [ion binding]; other site
309798002393	active-site loop [active]
309798002394	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
309798002395	non-specific DNA binding site [nucleotide binding]; other site
309798002396	salt bridge; other site
309798002397	sequence-specific DNA binding site [nucleotide binding]; other site
309798002398	Protein of unknown function (DUF3796); Region: DUF3796; pfam12676
309798002399	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
309798002400	NAD synthase; Region: NAD_synthase; pfam02540
309798002401	homodimer interface [polypeptide binding]; other site
309798002402	NAD binding pocket [chemical binding]; other site
309798002403	ATP binding pocket [chemical binding]; other site
309798002404	Mg binding site [ion binding]; other site
309798002405	active-site loop [active]
309798002406	trigger factor; Region: tig; TIGR00115
309798002407	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
309798002408	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
309798002409	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
309798002410	oligomer interface [polypeptide binding]; other site
309798002411	active site residues [active]
309798002412	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
309798002413	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
309798002414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002415	Walker A motif; other site
309798002416	ATP binding site [chemical binding]; other site
309798002417	Walker B motif; other site
309798002418	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
309798002419	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
309798002420	Found in ATP-dependent protease La (LON); Region: LON; smart00464
309798002421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002422	Walker A motif; other site
309798002423	ATP binding site [chemical binding]; other site
309798002424	Walker B motif; other site
309798002425	arginine finger; other site
309798002426	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
309798002427	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
309798002428	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
309798002429	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798002430	FeS/SAM binding site; other site
309798002431	Competence-damaged protein; Region: CinA; pfam02464
309798002432	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
309798002433	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
309798002434	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
309798002435	recombinase A; Provisional; Region: recA; PRK09354
309798002436	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
309798002437	hexamer interface [polypeptide binding]; other site
309798002438	Walker A motif; other site
309798002439	ATP binding site [chemical binding]; other site
309798002440	Walker B motif; other site
309798002441	RecX family; Region: RecX; cl00936
309798002442	phosphodiesterase; Provisional; Region: PRK12704
309798002443	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798002444	Zn2+ binding site [ion binding]; other site
309798002445	Mg2+ binding site [ion binding]; other site
309798002446	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
309798002447	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798002448	putative active site [active]
309798002449	metal binding site [ion binding]; metal-binding site
309798002450	homodimer binding site [polypeptide binding]; other site
309798002451	radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089
309798002452	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
309798002453	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798002454	FeS/SAM binding site; other site
309798002455	TRAM domain; Region: TRAM; pfam01938
309798002456	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
309798002457	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
309798002458	Aluminium resistance protein; Region: Alum_res; pfam06838
309798002459	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
309798002460	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
309798002461	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
309798002462	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
309798002463	active site
309798002464	dimer interface [polypeptide binding]; other site
309798002465	motif 1; other site
309798002466	motif 2; other site
309798002467	motif 3; other site
309798002468	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
309798002469	anticodon binding site; other site
309798002470	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
309798002471	lipoyl attachment site [posttranslational modification]; other site
309798002472	transcription termination factor Rho; Provisional; Region: rho; PRK09376
309798002473	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
309798002474	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
309798002475	RNA binding site [nucleotide binding]; other site
309798002476	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
309798002477	multimer interface [polypeptide binding]; other site
309798002478	Walker A motif; other site
309798002479	ATP binding site [chemical binding]; other site
309798002480	Walker B motif; other site
309798002481	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
309798002482	thymidine kinase; Provisional; Region: PRK04296
309798002483	peptide chain release factor 1; Validated; Region: prfA; PRK00591
309798002484	This domain is found in peptide chain release factors; Region: PCRF; smart00937
309798002485	RF-1 domain; Region: RF-1; pfam00472
309798002486	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
309798002487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798002488	S-adenosylmethionine binding site [chemical binding]; other site
309798002489	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
309798002490	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
309798002491	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
309798002492	TM-ABC transporter signature motif; other site
309798002493	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
309798002494	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
309798002495	Walker A/P-loop; other site
309798002496	ATP binding site [chemical binding]; other site
309798002497	Q-loop/lid; other site
309798002498	ABC transporter signature motif; other site
309798002499	Walker B; other site
309798002500	D-loop; other site
309798002501	H-loop/switch region; other site
309798002502	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
309798002503	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
309798002504	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
309798002505	putative ligand binding site [chemical binding]; other site
309798002506	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
309798002507	Rubredoxin; Region: Rubredoxin; pfam00301
309798002508	iron binding site [ion binding]; other site
309798002509	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
309798002510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002511	Walker A motif; other site
309798002512	ATP binding site [chemical binding]; other site
309798002513	Walker B motif; other site
309798002514	arginine finger; other site
309798002515	UvrB/uvrC motif; Region: UVR; pfam02151
309798002516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002517	Walker A motif; other site
309798002518	ATP binding site [chemical binding]; other site
309798002519	Walker B motif; other site
309798002520	arginine finger; other site
309798002521	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
309798002522	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
309798002523	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
309798002524	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
309798002525	active site
309798002526	P-loop; other site
309798002527	phosphorylation site [posttranslational modification]
309798002528	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
309798002529	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
309798002530	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
309798002531	tetramer interface [polypeptide binding]; other site
309798002532	TPP-binding site [chemical binding]; other site
309798002533	heterodimer interface [polypeptide binding]; other site
309798002534	phosphorylation loop region [posttranslational modification]
309798002535	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
309798002536	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
309798002537	alpha subunit interface [polypeptide binding]; other site
309798002538	TPP binding site [chemical binding]; other site
309798002539	heterodimer interface [polypeptide binding]; other site
309798002540	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
309798002541	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
309798002542	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
309798002543	E3 interaction surface; other site
309798002544	lipoyl attachment site [posttranslational modification]; other site
309798002545	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
309798002546	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
309798002547	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
309798002548	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
309798002549	AP endonuclease family 2; Region: AP2Ec; smart00518
309798002550	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
309798002551	AP (apurinic/apyrimidinic) site pocket; other site
309798002552	DNA interaction; other site
309798002553	Metal-binding active site; metal-binding site
309798002554	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
309798002555	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
309798002556	TM-ABC transporter signature motif; other site
309798002557	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
309798002558	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
309798002559	TM-ABC transporter signature motif; other site
309798002560	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
309798002561	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
309798002562	Walker A/P-loop; other site
309798002563	ATP binding site [chemical binding]; other site
309798002564	Q-loop/lid; other site
309798002565	ABC transporter signature motif; other site
309798002566	Walker B; other site
309798002567	D-loop; other site
309798002568	H-loop/switch region; other site
309798002569	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
309798002570	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
309798002571	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
309798002572	ligand binding site [chemical binding]; other site
309798002573	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
309798002574	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
309798002575	active site
309798002576	ADP/pyrophosphate binding site [chemical binding]; other site
309798002577	dimerization interface [polypeptide binding]; other site
309798002578	allosteric effector site; other site
309798002579	fructose-1,6-bisphosphate binding site; other site
309798002580	6-phosphofructokinase; Provisional; Region: PRK03202
309798002581	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
309798002582	active site
309798002583	ADP/pyrophosphate binding site [chemical binding]; other site
309798002584	dimerization interface [polypeptide binding]; other site
309798002585	allosteric effector site; other site
309798002586	fructose-1,6-bisphosphate binding site; other site
309798002587	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
309798002588	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
309798002589	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
309798002590	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
309798002591	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
309798002592	active site
309798002593	HIGH motif; other site
309798002594	nucleotide binding site [chemical binding]; other site
309798002595	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
309798002596	KMSKS motif; other site
309798002597	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
309798002598	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
309798002599	substrate binding site; other site
309798002600	dimer interface; other site
309798002601	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030
309798002602	homotrimer interaction site [polypeptide binding]; other site
309798002603	zinc binding site [ion binding]; other site
309798002604	CDP-binding sites; other site
309798002605	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
309798002606	putative active site [active]
309798002607	DNA repair protein RadA; Provisional; Region: PRK11823
309798002608	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
309798002609	Walker A motif; other site
309798002610	ATP binding site [chemical binding]; other site
309798002611	Walker B motif; other site
309798002612	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
309798002613	Clp amino terminal domain; Region: Clp_N; pfam02861
309798002614	Clp amino terminal domain; Region: Clp_N; pfam02861
309798002615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002616	Walker A motif; other site
309798002617	ATP binding site [chemical binding]; other site
309798002618	Walker B motif; other site
309798002619	arginine finger; other site
309798002620	UvrB/uvrC motif; Region: UVR; pfam02151
309798002621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002622	Walker A motif; other site
309798002623	ATP binding site [chemical binding]; other site
309798002624	Walker B motif; other site
309798002625	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
309798002626	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
309798002627	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
309798002628	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
309798002629	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
309798002630	domain interfaces; other site
309798002631	active site
309798002632	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
309798002633	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
309798002634	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
309798002635	adenylosuccinate lyase; Region: purB; TIGR00928
309798002636	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
309798002637	tetramer interface [polypeptide binding]; other site
309798002638	Fumarase C-terminus; Region: Fumerase_C; cl00795
309798002639	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
309798002640	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
309798002641	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
309798002642	nucleotide binding site/active site [active]
309798002643	HIT family signature motif; other site
309798002644	catalytic residue [active]
309798002645	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
309798002646	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
309798002647	ABC-ATPase subunit  interface; other site
309798002648	dimer interface [polypeptide binding]; other site
309798002649	putative PBP binding regions; other site
309798002650	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
309798002651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798002652	Walker A/P-loop; other site
309798002653	ATP binding site [chemical binding]; other site
309798002654	Q-loop/lid; other site
309798002655	ABC transporter signature motif; other site
309798002656	Walker B; other site
309798002657	D-loop; other site
309798002658	H-loop/switch region; other site
309798002659	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
309798002660	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
309798002661	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798002662	FeS/SAM binding site; other site
309798002663	RNA methyltransferase, RsmE family; Region: TIGR00046
309798002664	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
309798002665	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
309798002666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798002667	S-adenosylmethionine binding site [chemical binding]; other site
309798002668	Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420
309798002669	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
309798002670	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
309798002671	ABC-2 type transporter; Region: ABC2_membrane; cl17235
309798002672	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
309798002673	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
309798002674	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798002675	Walker A/P-loop; other site
309798002676	ATP binding site [chemical binding]; other site
309798002677	Q-loop/lid; other site
309798002678	ABC transporter signature motif; other site
309798002679	Walker B; other site
309798002680	D-loop; other site
309798002681	H-loop/switch region; other site
309798002682	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
309798002683	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253
309798002684	putative active site [active]
309798002685	dimerization interface [polypeptide binding]; other site
309798002686	putative tRNAtyr binding site [nucleotide binding]; other site
309798002687	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
309798002688	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798002689	Zn2+ binding site [ion binding]; other site
309798002690	Mg2+ binding site [ion binding]; other site
309798002691	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
309798002692	synthetase active site [active]
309798002693	NTP binding site [chemical binding]; other site
309798002694	metal binding site [ion binding]; metal-binding site
309798002695	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
309798002696	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
309798002697	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798002698	active site
309798002699	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
309798002700	Protein export membrane protein; Region: SecD_SecF; cl14618
309798002701	protein-export membrane protein SecD; Region: secD; TIGR01129
309798002702	Protein export membrane protein; Region: SecD_SecF; cl14618
309798002703	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
309798002704	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
309798002705	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
309798002706	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
309798002707	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
309798002708	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
309798002709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002710	Walker A motif; other site
309798002711	ATP binding site [chemical binding]; other site
309798002712	Walker B motif; other site
309798002713	arginine finger; other site
309798002714	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
309798002715	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
309798002716	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
309798002717	active site
309798002718	putative DNA-binding cleft [nucleotide binding]; other site
309798002719	dimer interface [polypeptide binding]; other site
309798002720	hypothetical protein; Validated; Region: PRK00110
309798002721	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
309798002722	active sites [active]
309798002723	tetramer interface [polypeptide binding]; other site
309798002724	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
309798002725	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
309798002726	carboxyltransferase (CT) interaction site; other site
309798002727	biotinylation site [posttranslational modification]; other site
309798002728	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
309798002729	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
309798002730	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
309798002731	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
309798002732	dimer interface [polypeptide binding]; other site
309798002733	substrate binding site [chemical binding]; other site
309798002734	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
309798002735	metal binding site [ion binding]; metal-binding site
309798002736	ArgK protein; Region: ArgK; pfam03308
309798002737	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
309798002738	Walker A; other site
309798002739	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
309798002740	Switch II region; other site
309798002741	G4 box; other site
309798002742	G5 box; other site
309798002743	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
309798002744	B12 binding site [chemical binding]; other site
309798002745	cobalt ligand [ion binding]; other site
309798002746	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
309798002747	FtsH Extracellular; Region: FtsH_ext; pfam06480
309798002748	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
309798002749	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798002750	Walker B motif; other site
309798002751	arginine finger; other site
309798002752	Peptidase family M41; Region: Peptidase_M41; pfam01434
309798002753	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798002754	active site
309798002755	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
309798002756	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
309798002757	Ligand Binding Site [chemical binding]; other site
309798002758	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
309798002759	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
309798002760	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
309798002761	NADH dehydrogenase; Region: NADHdh; cl00469
309798002762	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
309798002763	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
309798002764	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
309798002765	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
309798002766	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK08386
309798002767	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
309798002768	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
309798002769	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
309798002770	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
309798002771	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
309798002772	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
309798002773	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
309798002774	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
309798002775	Acylphosphatase; Region: Acylphosphatase; pfam00708
309798002776	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
309798002777	HypF finger; Region: zf-HYPF; pfam07503
309798002778	HypF finger; Region: zf-HYPF; pfam07503
309798002779	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
309798002780	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
309798002781	HupF/HypC family; Region: HupF_HypC; pfam01455
309798002782	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
309798002783	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
309798002784	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
309798002785	dimerization interface [polypeptide binding]; other site
309798002786	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
309798002787	ATP binding site [chemical binding]; other site
309798002788	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
309798002789	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
309798002790	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
309798002791	G1 box; other site
309798002792	GTP/Mg2+ binding site [chemical binding]; other site
309798002793	G2 box; other site
309798002794	Switch I region; other site
309798002795	G3 box; other site
309798002796	Switch II region; other site
309798002797	G4 box; other site
309798002798	G5 box; other site
309798002799	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
309798002800	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
309798002801	active site
309798002802	Riboflavin kinase; Region: Flavokinase; pfam01687
309798002803	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
309798002804	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
309798002805	active site
309798002806	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
309798002807	DHH family; Region: DHH; pfam01368
309798002808	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
309798002809	Protein of unknown function (DUF503); Region: DUF503; pfam04456
309798002810	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
309798002811	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
309798002812	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
309798002813	G1 box; other site
309798002814	putative GEF interaction site [polypeptide binding]; other site
309798002815	GTP/Mg2+ binding site [chemical binding]; other site
309798002816	Switch I region; other site
309798002817	G2 box; other site
309798002818	G3 box; other site
309798002819	Switch II region; other site
309798002820	G4 box; other site
309798002821	G5 box; other site
309798002822	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
309798002823	Translation-initiation factor 2; Region: IF-2; pfam11987
309798002824	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
309798002825	NusA N-terminal domain; Region: NusA_N; pfam08529
309798002826	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
309798002827	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
309798002828	RNA binding site [nucleotide binding]; other site
309798002829	homodimer interface [polypeptide binding]; other site
309798002830	NusA-like KH domain; Region: KH_5; pfam13184
309798002831	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
309798002832	G-X-X-G motif; other site
309798002833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779
309798002834	Sm and related proteins; Region: Sm_like; cl00259
309798002835	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
309798002836	putative oligomer interface [polypeptide binding]; other site
309798002837	putative RNA binding site [nucleotide binding]; other site
309798002838	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
309798002839	core dimer interface [polypeptide binding]; other site
309798002840	L10 interface [polypeptide binding]; other site
309798002841	L11 interface [polypeptide binding]; other site
309798002842	putative EF-Tu interaction site [polypeptide binding]; other site
309798002843	putative EF-G interaction site [polypeptide binding]; other site
309798002844	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
309798002845	23S rRNA interface [nucleotide binding]; other site
309798002846	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
309798002847	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
309798002848	mRNA/rRNA interface [nucleotide binding]; other site
309798002849	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
309798002850	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
309798002851	23S rRNA interface [nucleotide binding]; other site
309798002852	L7/L12 interface [polypeptide binding]; other site
309798002853	putative thiostrepton binding site; other site
309798002854	L25 interface [polypeptide binding]; other site
309798002855	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
309798002856	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
309798002857	putative homodimer interface [polypeptide binding]; other site
309798002858	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
309798002859	heterodimer interface [polypeptide binding]; other site
309798002860	homodimer interface [polypeptide binding]; other site
309798002861	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
309798002862	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
309798002863	elongation factor Tu; Reviewed; Region: PRK00049
309798002864	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
309798002865	G1 box; other site
309798002866	GEF interaction site [polypeptide binding]; other site
309798002867	GTP/Mg2+ binding site [chemical binding]; other site
309798002868	Switch I region; other site
309798002869	G2 box; other site
309798002870	G3 box; other site
309798002871	Switch II region; other site
309798002872	G4 box; other site
309798002873	G5 box; other site
309798002874	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
309798002875	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
309798002876	Antibiotic Binding Site [chemical binding]; other site
309798002877	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
309798002878	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165
309798002879	putative ligand binding site [chemical binding]; other site
309798002880	NAD binding site [chemical binding]; other site
309798002881	dimer interface [polypeptide binding]; other site
309798002882	putative catalytic site [active]
309798002883	Domain of unknown function (DUF814); Region: DUF814; pfam05670
309798002884	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
309798002885	C-terminal peptidase (prc); Region: prc; TIGR00225
309798002886	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
309798002887	protein binding site [polypeptide binding]; other site
309798002888	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
309798002889	Catalytic dyad [active]
309798002890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
309798002891	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
309798002892	Peptidase family M23; Region: Peptidase_M23; pfam01551
309798002893	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
309798002894	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
309798002895	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
309798002896	Walker A/P-loop; other site
309798002897	ATP binding site [chemical binding]; other site
309798002898	Q-loop/lid; other site
309798002899	ABC transporter signature motif; other site
309798002900	Walker B; other site
309798002901	D-loop; other site
309798002902	H-loop/switch region; other site
309798002903	peptide chain release factor 2; Validated; Region: prfB; PRK00578
309798002904	PCRF domain; Region: PCRF; pfam03462
309798002905	RF-1 domain; Region: RF-1; pfam00472
309798002906	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
309798002907	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
309798002908	ATP binding site [chemical binding]; other site
309798002909	putative Mg++ binding site [ion binding]; other site
309798002910	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
309798002911	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
309798002912	nucleotide binding region [chemical binding]; other site
309798002913	ATP-binding site [chemical binding]; other site
309798002914	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
309798002915	30S subunit binding site; other site
309798002916	Uncharacterized conserved protein [Function unknown]; Region: COG1284
309798002917	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
309798002918	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
309798002919	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
309798002920	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
309798002921	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
309798002922	trimer interface [polypeptide binding]; other site
309798002923	putative metal binding site [ion binding]; other site
309798002924	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
309798002925	active site
309798002926	S-adenosylmethionine synthetase; Validated; Region: PRK05250
309798002927	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
309798002928	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
309798002929	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
309798002930	Double zinc ribbon; Region: DZR; pfam12773
309798002931	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
309798002932	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
309798002933	active site
309798002934	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
309798002935	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
309798002936	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
309798002937	Walker A/P-loop; other site
309798002938	ATP binding site [chemical binding]; other site
309798002939	Q-loop/lid; other site
309798002940	ABC transporter signature motif; other site
309798002941	Walker B; other site
309798002942	D-loop; other site
309798002943	H-loop/switch region; other site
309798002944	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
309798002945	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
309798002946	Walker A/P-loop; other site
309798002947	ATP binding site [chemical binding]; other site
309798002948	Q-loop/lid; other site
309798002949	ABC transporter signature motif; other site
309798002950	Walker B; other site
309798002951	D-loop; other site
309798002952	H-loop/switch region; other site
309798002953	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
309798002954	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
309798002955	alphaNTD homodimer interface [polypeptide binding]; other site
309798002956	DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027
309798002957	alphaNTD - beta interaction site [polypeptide binding]; other site
309798002958	alphaNTD - beta' interaction site [polypeptide binding]; other site
309798002959	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
309798002960	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
309798002961	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
309798002962	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
309798002963	RNA binding surface [nucleotide binding]; other site
309798002964	30S ribosomal protein S11; Validated; Region: PRK05309
309798002965	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
309798002966	30S ribosomal protein S13; Region: bact_S13; TIGR03631
309798002967	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
309798002968	rRNA binding site [nucleotide binding]; other site
309798002969	predicted 30S ribosome binding site; other site
309798002970	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
309798002971	RNA binding site [nucleotide binding]; other site
309798002972	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
309798002973	active site
309798002974	adenylate kinase; Reviewed; Region: adk; PRK00279
309798002975	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
309798002976	AMP-binding site [chemical binding]; other site
309798002977	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
309798002978	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
309798002979	SecY translocase; Region: SecY; pfam00344
309798002980	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
309798002981	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
309798002982	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
309798002983	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
309798002984	5S rRNA interface [nucleotide binding]; other site
309798002985	L27 interface [polypeptide binding]; other site
309798002986	23S rRNA interface [nucleotide binding]; other site
309798002987	L5 interface [polypeptide binding]; other site
309798002988	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
309798002989	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
309798002990	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
309798002991	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
309798002992	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
309798002993	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
309798002994	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
309798002995	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
309798002996	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
309798002997	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
309798002998	RNA binding site [nucleotide binding]; other site
309798002999	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
309798003000	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
309798003001	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
309798003002	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
309798003003	signal recognition particle (SRP54) interaction site; other site
309798003004	L23 interface [polypeptide binding]; other site
309798003005	trigger factor interaction site; other site
309798003006	23S rRNA interface [nucleotide binding]; other site
309798003007	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
309798003008	23S rRNA interface [nucleotide binding]; other site
309798003009	5S rRNA interface [nucleotide binding]; other site
309798003010	putative antibiotic binding site [chemical binding]; other site
309798003011	L25 interface [polypeptide binding]; other site
309798003012	L27 interface [polypeptide binding]; other site
309798003013	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
309798003014	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
309798003015	G-X-X-G motif; other site
309798003016	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
309798003017	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
309798003018	putative translocon binding site; other site
309798003019	protein-rRNA interface [nucleotide binding]; other site
309798003020	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
309798003021	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
309798003022	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
309798003023	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
309798003024	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
309798003025	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
309798003026	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
309798003027	elongation factor Tu; Reviewed; Region: PRK00049
309798003028	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
309798003029	G1 box; other site
309798003030	GEF interaction site [polypeptide binding]; other site
309798003031	GTP/Mg2+ binding site [chemical binding]; other site
309798003032	Switch I region; other site
309798003033	G2 box; other site
309798003034	G3 box; other site
309798003035	Switch II region; other site
309798003036	G4 box; other site
309798003037	G5 box; other site
309798003038	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
309798003039	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
309798003040	Antibiotic Binding Site [chemical binding]; other site
309798003041	elongation factor G; Reviewed; Region: PRK00007
309798003042	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
309798003043	G1 box; other site
309798003044	putative GEF interaction site [polypeptide binding]; other site
309798003045	GTP/Mg2+ binding site [chemical binding]; other site
309798003046	Switch I region; other site
309798003047	G2 box; other site
309798003048	G3 box; other site
309798003049	Switch II region; other site
309798003050	G4 box; other site
309798003051	G5 box; other site
309798003052	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
309798003053	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
309798003054	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
309798003055	30S ribosomal protein S7; Validated; Region: PRK05302
309798003056	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
309798003057	S17 interaction site [polypeptide binding]; other site
309798003058	S8 interaction site; other site
309798003059	16S rRNA interaction site [nucleotide binding]; other site
309798003060	streptomycin interaction site [chemical binding]; other site
309798003061	23S rRNA interaction site [nucleotide binding]; other site
309798003062	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
309798003063	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
309798003064	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
309798003065	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
309798003066	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
309798003067	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
309798003068	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
309798003069	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
309798003070	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
309798003071	G-loop; other site
309798003072	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
309798003073	DNA binding site [nucleotide binding]
309798003074	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
309798003075	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
309798003076	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
309798003077	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
309798003078	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
309798003079	RPB10 interaction site [polypeptide binding]; other site
309798003080	RPB1 interaction site [polypeptide binding]; other site
309798003081	RPB11 interaction site [polypeptide binding]; other site
309798003082	RPB3 interaction site [polypeptide binding]; other site
309798003083	RPB12 interaction site [polypeptide binding]; other site
309798003084	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
309798003085	Carbon starvation protein CstA; Region: CstA; pfam02554
309798003086	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
309798003087	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
309798003088	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
309798003089	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
309798003090	Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419
309798003091	Ribonuclease HIII [DNA replication, recombination, and repair]; Region: RnhC; COG1039
309798003092	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
309798003093	RNA/DNA hybrid binding site [nucleotide binding]; other site
309798003094	active site
309798003095	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
309798003096	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
309798003097	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
309798003098	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
309798003099	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
309798003100	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
309798003101	minor groove reading motif; other site
309798003102	helix-hairpin-helix signature motif; other site
309798003103	substrate binding pocket [chemical binding]; other site
309798003104	active site
309798003105	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
309798003106	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
309798003107	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
309798003108	Potassium binding sites [ion binding]; other site
309798003109	Cesium cation binding sites [ion binding]; other site
309798003110	imidazolonepropionase; Validated; Region: PRK09356
309798003111	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
309798003112	active site
309798003113	glutamate formiminotransferase; Region: FtcD; TIGR02024
309798003114	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
309798003115	Formiminotransferase domain; Region: FTCD; pfam02971
309798003116	urocanate hydratase; Provisional; Region: PRK05414
309798003117	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
309798003118	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
309798003119	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
309798003120	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
309798003121	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
309798003122	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
309798003123	active site
309798003124	dimerization interface [polypeptide binding]; other site
309798003125	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
309798003126	EDD domain protein, DegV family; Region: DegV; TIGR00762
309798003127	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
309798003128	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
309798003129	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
309798003130	G-X-X-G motif; other site
309798003131	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
309798003132	RxxxH motif; other site
309798003133	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
309798003134	Haemolytic domain; Region: Haemolytic; cl00506
309798003135	Ribonuclease P; Region: Ribonuclease_P; pfam00825
309798003136	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
309798003137	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
309798003138	active site
309798003139	metal binding site [ion binding]; metal-binding site
309798003140	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
309798003141	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
309798003142	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
309798003143	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
309798003144	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
309798003145	Walker A motif; other site
309798003146	ATP binding site [chemical binding]; other site
309798003147	Walker B motif; other site
309798003148	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
309798003149	TM2 domain; Region: TM2; pfam05154
309798003150	TM2 domain; Region: TM2; pfam05154
309798003151	TM2 domain; Region: TM2; pfam05154
309798003152	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
309798003153	Ligand binding site; other site
309798003154	Putative Catalytic site; other site
309798003155	DXD motif; other site
309798003156	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
309798003157	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
309798003158	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
309798003159	homodimer interface [polypeptide binding]; other site
309798003160	NADP binding site [chemical binding]; other site
309798003161	substrate binding site [chemical binding]; other site
309798003162	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
309798003163	tetramer interface [polypeptide binding]; other site
309798003164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798003165	catalytic residue [active]
309798003166	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
309798003167	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
309798003168	tetramer interface [polypeptide binding]; other site
309798003169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798003170	catalytic residue [active]
309798003171	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
309798003172	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
309798003173	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
309798003174	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
309798003175	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
309798003176	inhibitor-cofactor binding pocket; inhibition site
309798003177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798003178	catalytic residue [active]
309798003179	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
309798003180	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
309798003181	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
309798003182	TrkA-N domain; Region: TrkA_N; pfam02254
309798003183	TrkA-C domain; Region: TrkA_C; pfam02080
309798003184	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
309798003185	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
309798003186	active site
309798003187	enolase; Provisional; Region: eno; PRK00077
309798003188	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
309798003189	dimer interface [polypeptide binding]; other site
309798003190	metal binding site [ion binding]; metal-binding site
309798003191	substrate binding pocket [chemical binding]; other site
309798003192	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
309798003193	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
309798003194	2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628
309798003195	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
309798003196	TPP-binding site [chemical binding]; other site
309798003197	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
309798003198	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
309798003199	dimer interface [polypeptide binding]; other site
309798003200	PYR/PP interface [polypeptide binding]; other site
309798003201	TPP binding site [chemical binding]; other site
309798003202	substrate binding site [chemical binding]; other site
309798003203	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
309798003204	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
309798003205	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
309798003206	active site
309798003207	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
309798003208	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
309798003209	active site
309798003210	HIGH motif; other site
309798003211	KMSKS motif; other site
309798003212	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
309798003213	tRNA binding surface [nucleotide binding]; other site
309798003214	anticodon binding site; other site
309798003215	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
309798003216	dimer interface [polypeptide binding]; other site
309798003217	putative tRNA-binding site [nucleotide binding]; other site
309798003218	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
309798003219	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
309798003220	glutaminase active site [active]
309798003221	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
309798003222	dimer interface [polypeptide binding]; other site
309798003223	active site
309798003224	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
309798003225	dimer interface [polypeptide binding]; other site
309798003226	active site
309798003227	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
309798003228	phosphoglucosamine mutase; Region: glmM; TIGR01455
309798003229	active site
309798003230	substrate binding site [chemical binding]; other site
309798003231	metal binding site [ion binding]; metal-binding site
309798003232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
309798003233	Uncharacterized conserved protein [Function unknown]; Region: COG1624
309798003234	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
309798003235	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
309798003236	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
309798003237	putative substrate binding site [chemical binding]; other site
309798003238	nucleotide binding site [chemical binding]; other site
309798003239	nucleotide binding site [chemical binding]; other site
309798003240	homodimer interface [polypeptide binding]; other site
309798003241	ornithine carbamoyltransferase; Provisional; Region: PRK00779
309798003242	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
309798003243	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
309798003244	Predicted GTPase [General function prediction only]; Region: COG2403
309798003245	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
309798003246	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
309798003247	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
309798003248	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
309798003249	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
309798003250	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
309798003251	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798003252	FeS/SAM binding site; other site
309798003253	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
309798003254	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
309798003255	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
309798003256	HflX GTPase family; Region: HflX; cd01878
309798003257	G1 box; other site
309798003258	GTP/Mg2+ binding site [chemical binding]; other site
309798003259	Switch I region; other site
309798003260	G2 box; other site
309798003261	G3 box; other site
309798003262	Switch II region; other site
309798003263	G4 box; other site
309798003264	G5 box; other site
309798003265	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
309798003266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798003267	ATP binding site [chemical binding]; other site
309798003268	Mg2+ binding site [ion binding]; other site
309798003269	G-X-G motif; other site
309798003270	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
309798003271	ATP binding site [chemical binding]; other site
309798003272	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
309798003273	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
309798003274	MutS domain I; Region: MutS_I; pfam01624
309798003275	MutS domain III; Region: MutS_III; pfam05192
309798003276	MutS domain V; Region: MutS_V; pfam00488
309798003277	Walker A/P-loop; other site
309798003278	ATP binding site [chemical binding]; other site
309798003279	Q-loop/lid; other site
309798003280	ABC transporter signature motif; other site
309798003281	Walker B; other site
309798003282	D-loop; other site
309798003283	H-loop/switch region; other site
309798003284	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
309798003285	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
309798003286	dimer interface [polypeptide binding]; other site
309798003287	active site
309798003288	metal binding site [ion binding]; metal-binding site
309798003289	Putative amidase domain; Region: Amidase_6; pfam12671
309798003290	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
309798003291	diiron binding motif [ion binding]; other site
309798003292	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
309798003293	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
309798003294	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
309798003295	dimer interface [polypeptide binding]; other site
309798003296	catalytic triad [active]
309798003297	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
309798003298	Ferritin-like domain; Region: Ferritin; pfam00210
309798003299	ferroxidase diiron center [ion binding]; other site
309798003300	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
309798003301	Peptidase family M50; Region: Peptidase_M50; pfam02163
309798003302	active site
309798003303	putative substrate binding region [chemical binding]; other site
309798003304	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
309798003305	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
309798003306	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
309798003307	Walker A/P-loop; other site
309798003308	ATP binding site [chemical binding]; other site
309798003309	Q-loop/lid; other site
309798003310	ABC transporter signature motif; other site
309798003311	Walker B; other site
309798003312	D-loop; other site
309798003313	H-loop/switch region; other site
309798003314	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
309798003315	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
309798003316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798003317	Walker A/P-loop; other site
309798003318	ATP binding site [chemical binding]; other site
309798003319	Q-loop/lid; other site
309798003320	ABC transporter signature motif; other site
309798003321	Walker B; other site
309798003322	D-loop; other site
309798003323	H-loop/switch region; other site
309798003324	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
309798003325	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
309798003326	dimer interface [polypeptide binding]; other site
309798003327	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
309798003328	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
309798003329	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
309798003330	QueT transporter; Region: QueT; pfam06177
309798003331	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
309798003332	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
309798003333	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
309798003334	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
309798003335	dimer interface [polypeptide binding]; other site
309798003336	putative anticodon binding site; other site
309798003337	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
309798003338	motif 1; other site
309798003339	active site
309798003340	motif 2; other site
309798003341	motif 3; other site
309798003342	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
309798003343	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
309798003344	Predicted dehydrogenase [General function prediction only]; Region: COG5322
309798003345	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
309798003346	NAD(P) binding pocket [chemical binding]; other site
309798003347	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
309798003348	active site
309798003349	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
309798003350	DNA topoisomerase III; Provisional; Region: PRK07726
309798003351	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
309798003352	active site
309798003353	putative interdomain interaction site [polypeptide binding]; other site
309798003354	putative metal-binding site [ion binding]; other site
309798003355	putative nucleotide binding site [chemical binding]; other site
309798003356	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
309798003357	domain I; other site
309798003358	DNA binding groove [nucleotide binding]
309798003359	phosphate binding site [ion binding]; other site
309798003360	domain II; other site
309798003361	domain III; other site
309798003362	nucleotide binding site [chemical binding]; other site
309798003363	catalytic site [active]
309798003364	domain IV; other site
309798003365	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
309798003366	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
309798003367	MoaE interaction surface [polypeptide binding]; other site
309798003368	MoeB interaction surface [polypeptide binding]; other site
309798003369	thiocarboxylated glycine; other site
309798003370	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
309798003371	MoaE homodimer interface [polypeptide binding]; other site
309798003372	MoaD interaction [polypeptide binding]; other site
309798003373	active site residues [active]
309798003374	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
309798003375	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
309798003376	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
309798003377	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
309798003378	Walker A/P-loop; other site
309798003379	ATP binding site [chemical binding]; other site
309798003380	Q-loop/lid; other site
309798003381	ABC transporter signature motif; other site
309798003382	Walker B; other site
309798003383	D-loop; other site
309798003384	H-loop/switch region; other site
309798003385	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
309798003386	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
309798003387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798003388	Walker A/P-loop; other site
309798003389	ATP binding site [chemical binding]; other site
309798003390	Q-loop/lid; other site
309798003391	ABC transporter signature motif; other site
309798003392	Walker B; other site
309798003393	D-loop; other site
309798003394	H-loop/switch region; other site
309798003395	Transcriptional regulators [Transcription]; Region: MarR; COG1846
309798003396	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
309798003397	non-specific DNA interactions [nucleotide binding]; other site
309798003398	DNA binding site [nucleotide binding]
309798003399	sequence specific DNA binding site [nucleotide binding]; other site
309798003400	putative cAMP binding site [chemical binding]; other site
309798003401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798003402	Major Facilitator Superfamily; Region: MFS_1; pfam07690
309798003403	putative substrate translocation pore; other site
309798003404	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
309798003405	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
309798003406	catalytic residue [active]
309798003407	putative FPP diphosphate  binding site; other site
309798003408	putative FPP binding hydrophobic cleft; other site
309798003409	dimer interface [polypeptide binding]; other site
309798003410	putative IPP diphosphate binding site; other site
309798003411	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
309798003412	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
309798003413	P-loop; other site
309798003414	Magnesium ion binding site [ion binding]; other site
309798003415	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
309798003416	ParB-like nuclease domain; Region: ParB; smart00470
309798003417	Type III pantothenate kinase; Region: Pan_kinase; pfam03309
309798003418	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
309798003419	active site
309798003420	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
309798003421	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
309798003422	dimer interface [polypeptide binding]; other site
309798003423	N-terminal domain interface [polypeptide binding]; other site
309798003424	sulfate 1 binding site; other site
309798003425	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
309798003426	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
309798003427	ligand binding site; other site
309798003428	oligomer interface; other site
309798003429	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
309798003430	dimer interface [polypeptide binding]; other site
309798003431	N-terminal domain interface [polypeptide binding]; other site
309798003432	sulfate 1 binding site; other site
309798003433	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
309798003434	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
309798003435	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
309798003436	diiron binding motif [ion binding]; other site
309798003437	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
309798003438	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
309798003439	G1 box; other site
309798003440	GTP/Mg2+ binding site [chemical binding]; other site
309798003441	Switch I region; other site
309798003442	G2 box; other site
309798003443	G3 box; other site
309798003444	Switch II region; other site
309798003445	G4 box; other site
309798003446	G5 box; other site
309798003447	Nucleoside recognition; Region: Gate; pfam07670
309798003448	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
309798003449	Nucleoside recognition; Region: Gate; pfam07670
309798003450	FeoA domain; Region: FeoA; pfam04023
309798003451	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
309798003452	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
309798003453	N-acetyl-D-glucosamine binding site [chemical binding]; other site
309798003454	catalytic residue [active]
309798003455	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
309798003456	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
309798003457	active site
309798003458	metal binding site [ion binding]; metal-binding site
309798003459	Thiamine pyrophosphokinase; Region: TPK; cd07995
309798003460	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
309798003461	active site
309798003462	dimerization interface [polypeptide binding]; other site
309798003463	thiamine binding site [chemical binding]; other site
309798003464	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
309798003465	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
309798003466	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
309798003467	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
309798003468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798003469	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
309798003470	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
309798003471	active site
309798003472	PHP Thumb interface [polypeptide binding]; other site
309798003473	metal binding site [ion binding]; metal-binding site
309798003474	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
309798003475	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
309798003476	generic binding surface I; other site
309798003477	generic binding surface II; other site
309798003478	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
309798003479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
309798003480	active site
309798003481	phosphorylation site [posttranslational modification]
309798003482	intermolecular recognition site; other site
309798003483	dimerization interface [polypeptide binding]; other site
309798003484	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
309798003485	DNA binding site [nucleotide binding]
309798003486	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
309798003487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
309798003488	ATP binding site [chemical binding]; other site
309798003489	Mg2+ binding site [ion binding]; other site
309798003490	G-X-G motif; other site
309798003491	PBP superfamily domain; Region: PBP_like_2; cl17296
309798003492	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
309798003493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798003494	dimer interface [polypeptide binding]; other site
309798003495	conserved gate region; other site
309798003496	putative PBP binding loops; other site
309798003497	ABC-ATPase subunit interface; other site
309798003498	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
309798003499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798003500	dimer interface [polypeptide binding]; other site
309798003501	conserved gate region; other site
309798003502	putative PBP binding loops; other site
309798003503	ABC-ATPase subunit interface; other site
309798003504	Protein of unknown function (DUF1602); Region: DUF1602; pfam07673
309798003505	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
309798003506	PhoU domain; Region: PhoU; pfam01895
309798003507	PhoU domain; Region: PhoU; pfam01895
309798003508	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
309798003509	FAD binding domain; Region: FAD_binding_4; pfam01565
309798003510	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
309798003511	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
309798003512	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
309798003513	NodB motif; other site
309798003514	active site
309798003515	catalytic site [active]
309798003516	metal binding site [ion binding]; metal-binding site
309798003517	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
309798003518	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
309798003519	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
309798003520	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
309798003521	DXD motif; other site
309798003522	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
309798003523	DNA-binding site [nucleotide binding]; DNA binding site
309798003524	RNA-binding motif; other site
309798003525	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
309798003526	DNA-binding site [nucleotide binding]; DNA binding site
309798003527	RNA-binding motif; other site
309798003528	MarR family; Region: MarR_2; pfam12802
309798003529	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
309798003530	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
309798003531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798003532	Major Facilitator Superfamily; Region: MFS_1; pfam07690
309798003533	putative substrate translocation pore; other site
309798003534	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
309798003535	Arginine repressor [Transcription]; Region: ArgR; COG1438
309798003536	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
309798003537	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
309798003538	elongation factor G; Reviewed; Region: PRK12740
309798003539	G1 box; other site
309798003540	putative GEF interaction site [polypeptide binding]; other site
309798003541	GTP/Mg2+ binding site [chemical binding]; other site
309798003542	Switch I region; other site
309798003543	G2 box; other site
309798003544	G3 box; other site
309798003545	Switch II region; other site
309798003546	G4 box; other site
309798003547	G5 box; other site
309798003548	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
309798003549	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
309798003550	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
309798003551	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
309798003552	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
309798003553	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
309798003554	catalytic residues [active]
309798003555	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
309798003556	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
309798003557	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
309798003558	trimerization site [polypeptide binding]; other site
309798003559	active site
309798003560	Domain of unknown function DUF59; Region: DUF59; pfam01883
309798003561	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
309798003562	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
309798003563	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
309798003564	catalytic residue [active]
309798003565	Metal-sensitive transcriptional repressor; Region: Trns_repr_metal; pfam02583
309798003566	putative homodimer interface [polypeptide binding]; other site
309798003567	putative homotetramer interface [polypeptide binding]; other site
309798003568	putative allosteric switch controlling residues; other site
309798003569	putative metal binding site [ion binding]; other site
309798003570	putative homodimer-homodimer interface [polypeptide binding]; other site
309798003571	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
309798003572	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
309798003573	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
309798003574	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
309798003575	dimer interface [polypeptide binding]; other site
309798003576	PYR/PP interface [polypeptide binding]; other site
309798003577	TPP binding site [chemical binding]; other site
309798003578	substrate binding site [chemical binding]; other site
309798003579	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
309798003580	TPP-binding site; other site
309798003581	4Fe-4S binding domain; Region: Fer4; pfam00037
309798003582	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
309798003583	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
309798003584	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
309798003585	PhoU domain; Region: PhoU; pfam01895
309798003586	PhoU domain; Region: PhoU; pfam01895
309798003587	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
309798003588	proposed catalytic triad [active]
309798003589	conserved cys residue [active]
309798003590	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
309798003591	homotrimer interaction site [polypeptide binding]; other site
309798003592	putative active site [active]
309798003593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798003594	Major Facilitator Superfamily; Region: MFS_1; pfam07690
309798003595	putative substrate translocation pore; other site
309798003596	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
309798003597	homodimer interface [polypeptide binding]; other site
309798003598	active site
309798003599	catalytic site [active]
309798003600	maltose binding site 2 [chemical binding]; other site
309798003601	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
309798003602	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
309798003603	molybdopterin cofactor binding site; other site
309798003604	Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568
309798003605	molybdopterin cofactor binding site; other site
309798003606	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
309798003607	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
309798003608	inhibitor site; inhibition site
309798003609	active site
309798003610	dimer interface [polypeptide binding]; other site
309798003611	catalytic residue [active]
309798003612	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
309798003613	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
309798003614	HemN C-terminal domain; Region: HemN_C; pfam06969
309798003615	GTP-binding protein LepA; Provisional; Region: PRK05433
309798003616	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
309798003617	G1 box; other site
309798003618	putative GEF interaction site [polypeptide binding]; other site
309798003619	GTP/Mg2+ binding site [chemical binding]; other site
309798003620	Switch I region; other site
309798003621	G2 box; other site
309798003622	G3 box; other site
309798003623	Switch II region; other site
309798003624	G4 box; other site
309798003625	G5 box; other site
309798003626	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
309798003627	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
309798003628	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
309798003629	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
309798003630	Flavoprotein; Region: Flavoprotein; pfam02441
309798003631	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
309798003632	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
309798003633	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
309798003634	catalytic site [active]
309798003635	G-X2-G-X-G-K; other site
309798003636	Domain of unknown function (DUF370); Region: DUF370; cl00898
309798003637	Threonine dehydrogenase; Region: TDH; cd05281
309798003638	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
309798003639	structural Zn binding site [ion binding]; other site
309798003640	catalytic Zn binding site [ion binding]; other site
309798003641	tetramer interface [polypeptide binding]; other site
309798003642	NADP binding site [chemical binding]; other site
309798003643	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
309798003644	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
309798003645	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
309798003646	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
309798003647	hypothetical protein; Provisional; Region: PRK02947
309798003648	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
309798003649	putative active site [active]
309798003650	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
309798003651	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
309798003652	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
309798003653	active site
309798003654	phosphorylation site [posttranslational modification]
309798003655	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
309798003656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
309798003657	DNA-binding site [nucleotide binding]; DNA binding site
309798003658	UTRA domain; Region: UTRA; pfam07702
309798003659	aspartate aminotransferase; Provisional; Region: PRK05764
309798003660	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
309798003661	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798003662	homodimer interface [polypeptide binding]; other site
309798003663	catalytic residue [active]
309798003664	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
309798003665	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
309798003666	minor groove reading motif; other site
309798003667	helix-hairpin-helix signature motif; other site
309798003668	active site
309798003669	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
309798003670	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
309798003671	TPP-binding site [chemical binding]; other site
309798003672	putative dimer interface [polypeptide binding]; other site
309798003673	pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367
309798003674	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
309798003675	dimer interface [polypeptide binding]; other site
309798003676	PYR/PP interface [polypeptide binding]; other site
309798003677	TPP binding site [chemical binding]; other site
309798003678	substrate binding site [chemical binding]; other site
309798003679	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
309798003680	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
309798003681	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
309798003682	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
309798003683	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
309798003684	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
309798003685	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
309798003686	active site
309798003687	HIGH motif; other site
309798003688	dimer interface [polypeptide binding]; other site
309798003689	KMSKS motif; other site
309798003690	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
309798003691	RNA binding surface [nucleotide binding]; other site
309798003692	Transglycosylase; Region: Transgly; pfam00912
309798003693	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
309798003694	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
309798003695	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
309798003696	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
309798003697	active site
309798003698	Zn binding site [ion binding]; other site
309798003699	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
309798003700	Peptidase family M23; Region: Peptidase_M23; pfam01551
309798003701	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
309798003702	Bifunctional nuclease; Region: DNase-RNase; cl00553
309798003703	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
309798003704	hydroxyglutarate oxidase; Provisional; Region: PRK11728
309798003705	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
309798003706	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
309798003707	4Fe-4S binding domain; Region: Fer4; pfam00037
309798003708	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
309798003709	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
309798003710	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
309798003711	FtsX-like permease family; Region: FtsX; pfam02687
309798003712	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
309798003713	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
309798003714	Walker A/P-loop; other site
309798003715	ATP binding site [chemical binding]; other site
309798003716	Q-loop/lid; other site
309798003717	ABC transporter signature motif; other site
309798003718	Walker B; other site
309798003719	D-loop; other site
309798003720	H-loop/switch region; other site
309798003721	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
309798003722	HlyD family secretion protein; Region: HlyD_3; pfam13437
309798003723	putative membrane fusion protein; Region: TIGR02828
309798003724	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
309798003725	non-heme iron binding site [ion binding]; other site
309798003726	tetramer interface [polypeptide binding]; other site
309798003727	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
309798003728	Ferritin-like domain; Region: Ferritin; pfam00210
309798003729	diiron binding motif [ion binding]; other site
309798003730	charged pocket; other site
309798003731	hydrophobic patch; other site
309798003732	Ubiquitin-like proteins; Region: UBQ; cl00155
309798003733	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
309798003734	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
309798003735	substrate binding site [chemical binding]; other site
309798003736	ATP binding site [chemical binding]; other site
309798003737	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798003738	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
309798003739	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
309798003740	GIY-YIG motif/motif A; other site
309798003741	active site
309798003742	catalytic site [active]
309798003743	putative DNA binding site [nucleotide binding]; other site
309798003744	metal binding site [ion binding]; metal-binding site
309798003745	UvrB/uvrC motif; Region: UVR; pfam02151
309798003746	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
309798003747	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
309798003748	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
309798003749	N-acetyl-D-glucosamine binding site [chemical binding]; other site
309798003750	catalytic residue [active]
309798003751	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
309798003752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798003753	Walker A/P-loop; other site
309798003754	ATP binding site [chemical binding]; other site
309798003755	Q-loop/lid; other site
309798003756	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798003757	Zn2+ binding site [ion binding]; other site
309798003758	Mg2+ binding site [ion binding]; other site
309798003759	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
309798003760	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
309798003761	RNA binding site [nucleotide binding]; other site
309798003762	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
309798003763	RNA binding site [nucleotide binding]; other site
309798003764	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
309798003765	RNA binding site [nucleotide binding]; other site
309798003766	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
309798003767	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
309798003768	RNA binding site [nucleotide binding]; other site
309798003769	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
309798003770	RNA binding site [nucleotide binding]; other site
309798003771	domain interface; other site
309798003772	LabA_like proteins; Region: LabA_like; cd06167
309798003773	putative metal binding site [ion binding]; other site
309798003774	Uncharacterized conserved protein [Function unknown]; Region: COG1432
309798003775	YibE/F-like protein; Region: YibE_F; pfam07907
309798003776	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
309798003777	putative catalytic site [active]
309798003778	putative phosphate binding site [ion binding]; other site
309798003779	active site
309798003780	metal binding site A [ion binding]; metal-binding site
309798003781	DNA binding site [nucleotide binding]
309798003782	putative AP binding site [nucleotide binding]; other site
309798003783	putative metal binding site B [ion binding]; other site
309798003784	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
309798003785	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
309798003786	active site
309798003787	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
309798003788	dimer interface [polypeptide binding]; other site
309798003789	substrate binding site [chemical binding]; other site
309798003790	catalytic residues [active]
309798003791	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
309798003792	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
309798003793	substrate binding pocket [chemical binding]; other site
309798003794	membrane-bound complex binding site; other site
309798003795	hinge residues; other site
309798003796	GAF domain; Region: GAF_3; pfam13492
309798003797	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
309798003798	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798003799	Zn2+ binding site [ion binding]; other site
309798003800	Mg2+ binding site [ion binding]; other site
309798003801	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
309798003802	trimer interface [polypeptide binding]; other site
309798003803	active site
309798003804	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
309798003805	catalytic center binding site [active]
309798003806	ATP binding site [chemical binding]; other site
309798003807	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
309798003808	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
309798003809	dihydropteroate synthase; Region: DHPS; TIGR01496
309798003810	substrate binding pocket [chemical binding]; other site
309798003811	dimer interface [polypeptide binding]; other site
309798003812	inhibitor binding site; inhibition site
309798003813	Acylphosphatase; Region: Acylphosphatase; pfam00708
309798003814	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
309798003815	dimer interface [polypeptide binding]; other site
309798003816	putative CheW interface [polypeptide binding]; other site
309798003817	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
309798003818	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
309798003819	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
309798003820	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
309798003821	DNA binding residues [nucleotide binding]
309798003822	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
309798003823	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798003824	FeS/SAM binding site; other site
309798003825	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
309798003826	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
309798003827	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
309798003828	FAD binding pocket [chemical binding]; other site
309798003829	FAD binding motif [chemical binding]; other site
309798003830	phosphate binding motif [ion binding]; other site
309798003831	beta-alpha-beta structure motif; other site
309798003832	NAD binding pocket [chemical binding]; other site
309798003833	Iron coordination center [ion binding]; other site
309798003834	putative oxidoreductase; Provisional; Region: PRK12831
309798003835	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
309798003836	active site
309798003837	intersubunit interactions; other site
309798003838	catalytic residue [active]
309798003839	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
309798003840	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
309798003841	H+ Antiporter protein; Region: 2A0121; TIGR00900
309798003842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798003843	putative substrate translocation pore; other site
309798003844	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798003845	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
309798003846	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
309798003847	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
309798003848	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
309798003849	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
309798003850	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
309798003851	peptidase T; Region: peptidase-T; TIGR01882
309798003852	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
309798003853	metal binding site [ion binding]; metal-binding site
309798003854	dimer interface [polypeptide binding]; other site
309798003855	recombination factor protein RarA; Reviewed; Region: PRK13342
309798003856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
309798003857	Walker A motif; other site
309798003858	ATP binding site [chemical binding]; other site
309798003859	Walker B motif; other site
309798003860	arginine finger; other site
309798003861	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
309798003862	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
309798003863	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
309798003864	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
309798003865	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
309798003866	metal-binding site [ion binding]
309798003867	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
309798003868	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
309798003869	motif II; other site
309798003870	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
309798003871	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
309798003872	aspartate racemase; Region: asp_race; TIGR00035
309798003873	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
309798003874	Predicted membrane protein [Function unknown]; Region: COG1297
309798003875	putative oligopeptide transporter, OPT family; Region: TIGR00733
309798003876	RNase_H superfamily; Region: RNase_H_2; pfam13482
309798003877	active site
309798003878	substrate binding site [chemical binding]; other site
309798003879	catalytic site [active]
309798003880	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
309798003881	Domain of unknown function DUF21; Region: DUF21; pfam01595
309798003882	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
309798003883	Transporter associated domain; Region: CorC_HlyC; smart01091
309798003884	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
309798003885	putative homotetramer interface [polypeptide binding]; other site
309798003886	putative homodimer interface [polypeptide binding]; other site
309798003887	putative allosteric switch controlling residues; other site
309798003888	putative metal binding site [ion binding]; other site
309798003889	putative homodimer-homodimer interface [polypeptide binding]; other site
309798003890	XapX domain; Region: XapX; TIGR03510
309798003891	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
309798003892	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
309798003893	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
309798003894	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
309798003895	Ligand Binding Site [chemical binding]; other site
309798003896	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
309798003897	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
309798003898	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
309798003899	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
309798003900	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
309798003901	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
309798003902	G5 domain; Region: G5; pfam07501
309798003903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
309798003904	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
309798003905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798003906	S-adenosylmethionine binding site [chemical binding]; other site
309798003907	glutamine synthetase, type I; Region: GlnA; TIGR00653
309798003908	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
309798003909	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
309798003910	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611
309798003911	active site
309798003912	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
309798003913	O-Antigen ligase; Region: Wzy_C; pfam04932
309798003914	Tetratricopeptide repeat; Region: TPR_12; pfam13424
309798003915	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
309798003916	TPR motif; other site
309798003917	binding surface
309798003918	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
309798003919	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
309798003920	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
309798003921	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
309798003922	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
309798003923	substrate-cofactor binding pocket; other site
309798003924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798003925	catalytic residue [active]
309798003926	integral membrane protein MviN; Region: mviN; TIGR01695
309798003927	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
309798003928	GTP-binding protein YchF; Reviewed; Region: PRK09601
309798003929	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
309798003930	G1 box; other site
309798003931	GTP/Mg2+ binding site [chemical binding]; other site
309798003932	Switch I region; other site
309798003933	G3 box; other site
309798003934	Switch II region; other site
309798003935	G4 box; other site
309798003936	G5 box; other site
309798003937	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
309798003938	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
309798003939	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
309798003940	active site
309798003941	nucleophile elbow; other site
309798003942	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
309798003943	active site
309798003944	spermidine synthase; Provisional; Region: PRK00811
309798003945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798003946	S-adenosylmethionine binding site [chemical binding]; other site
309798003947	S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK04025
309798003948	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
309798003949	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
309798003950	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
309798003951	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
309798003952	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
309798003953	dimer interface [polypeptide binding]; other site
309798003954	active site
309798003955	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
309798003956	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
309798003957	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
309798003958	putative active site [active]
309798003959	catalytic site [active]
309798003960	N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793
309798003961	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
309798003962	active site
309798003963	catalytic site [active]
309798003964	homodimer interface [polypeptide binding]; other site
309798003965	Lid 1; other site
309798003966	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
309798003967	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
309798003968	Uncharacterized conserved protein [Function unknown]; Region: COG1543
309798003969	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
309798003970	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
309798003971	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
309798003972	Na2 binding site [ion binding]; other site
309798003973	putative substrate binding site 1 [chemical binding]; other site
309798003974	Na binding site 1 [ion binding]; other site
309798003975	putative substrate binding site 2 [chemical binding]; other site
309798003976	ADP-glucose phosphorylase; Region: PLN02643
309798003977	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
309798003978	dimer interface [polypeptide binding]; other site
309798003979	active site
309798003980	glycogen synthase; Provisional; Region: glgA; PRK00654
309798003981	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
309798003982	ADP-binding pocket [chemical binding]; other site
309798003983	homodimer interface [polypeptide binding]; other site
309798003984	Predicted amidohydrolase [General function prediction only]; Region: COG0388
309798003985	Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577
309798003986	putative active site [active]
309798003987	catalytic triad [active]
309798003988	dimer interface [polypeptide binding]; other site
309798003989	putative tetramer interface [polypeptide binding]; other site
309798003990	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
309798003991	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798003992	active site
309798003993	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
309798003994	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
309798003995	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
309798003996	dihydroorotase; Validated; Region: pyrC; PRK09357
309798003997	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
309798003998	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
309798003999	active site
309798004000	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
309798004001	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
309798004002	FAD binding pocket [chemical binding]; other site
309798004003	conserved FAD binding motif [chemical binding]; other site
309798004004	phosphate binding motif [ion binding]; other site
309798004005	beta-alpha-beta structure motif; other site
309798004006	NAD binding pocket [chemical binding]; other site
309798004007	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
309798004008	heterodimer interface [polypeptide binding]; other site
309798004009	active site
309798004010	FMN binding site [chemical binding]; other site
309798004011	homodimer interface [polypeptide binding]; other site
309798004012	substrate binding site [chemical binding]; other site
309798004013	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
309798004014	active site
309798004015	dimer interface [polypeptide binding]; other site
309798004016	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798004017	active site
309798004018	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
309798004019	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
309798004020	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
309798004021	catalytic residue [active]
309798004022	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
309798004023	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798004024	active site
309798004025	metal binding site [ion binding]; metal-binding site
309798004026	homotetramer interface [polypeptide binding]; other site
309798004027	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
309798004028	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
309798004029	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
309798004030	catalytic core [active]
309798004031	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
309798004032	catalytic core [active]
309798004033	alanine-tRNA ligase; Region: PLN02961
309798004034	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
309798004035	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
309798004036	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
309798004037	motif II; other site
309798004038	Predicted amidohydrolase [General function prediction only]; Region: COG0388
309798004039	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
309798004040	putative active site [active]
309798004041	catalytic triad [active]
309798004042	putative dimer interface [polypeptide binding]; other site
309798004043	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
309798004044	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
309798004045	active site
309798004046	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
309798004047	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
309798004048	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
309798004049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
309798004050	NAD(P) binding site [chemical binding]; other site
309798004051	active site
309798004052	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
309798004053	active site
309798004054	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
309798004055	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
309798004056	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
309798004057	Predicted permeases [General function prediction only]; Region: COG0679
309798004058	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
309798004059	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
309798004060	Methyltransferase domain; Region: Methyltransf_31; pfam13847
309798004061	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798004062	S-adenosylmethionine binding site [chemical binding]; other site
309798004063	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
309798004064	putative homodimer interface [polypeptide binding]; other site
309798004065	putative active site pocket [active]
309798004066	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
309798004067	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
309798004068	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
309798004069	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
309798004070	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
309798004071	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
309798004072	dimerization domain swap beta strand [polypeptide binding]; other site
309798004073	regulatory protein interface [polypeptide binding]; other site
309798004074	active site
309798004075	regulatory phosphorylation site [posttranslational modification]; other site
309798004076	Hemerythrin; Region: Hemerythrin; cd12107
309798004077	Fe binding site [ion binding]; other site
309798004078	Hemerythrin; Region: Hemerythrin; cd12107
309798004079	Fe binding site [ion binding]; other site
309798004080	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
309798004081	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
309798004082	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
309798004083	metal binding site [ion binding]; metal-binding site
309798004084	dimer interface [polypeptide binding]; other site
309798004085	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
309798004086	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
309798004087	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
309798004088	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
309798004089	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
309798004090	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
309798004091	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
309798004092	Zn2+ binding site [ion binding]; other site
309798004093	Mg2+ binding site [ion binding]; other site
309798004094	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
309798004095	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
309798004096	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
309798004097	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
309798004098	catalytic residue [active]
309798004099	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
309798004100	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
309798004101	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
309798004102	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
309798004103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
309798004104	motif II; other site
309798004105	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
309798004106	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
309798004107	putative substrate binding pocket [chemical binding]; other site
309798004108	AC domain interface; other site
309798004109	catalytic triad [active]
309798004110	AB domain interface; other site
309798004111	interchain disulfide; other site
309798004112	Predicted membrane protein [Function unknown]; Region: COG3817
309798004113	Protein of unknown function (DUF979); Region: DUF979; pfam06166
309798004114	Protein of unknown function (DUF969); Region: DUF969; pfam06149
309798004115	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
309798004116	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
309798004117	alpha subunit interface [polypeptide binding]; other site
309798004118	TPP binding site [chemical binding]; other site
309798004119	heterodimer interface [polypeptide binding]; other site
309798004120	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
309798004121	Transposase; Region: DEDD_Tnp_IS110; pfam01548
309798004122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
309798004123	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
309798004124	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
309798004125	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
309798004126	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
309798004127	OsmC-like protein; Region: OsmC; cl00767
309798004128	OsmC-like protein; Region: OsmC; pfam02566
309798004129	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
309798004130	putative ADP-ribose binding site [chemical binding]; other site
309798004131	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
309798004132	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
309798004133	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
309798004134	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
309798004135	Soluble P-type ATPase [General function prediction only]; Region: COG4087
309798004136	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
309798004137	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
309798004138	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
309798004139	Transposase; Region: DEDD_Tnp_IS110; pfam01548
309798004140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
309798004141	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
309798004142	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
309798004143	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
309798004144	tetramer interface [polypeptide binding]; other site
309798004145	TPP-binding site [chemical binding]; other site
309798004146	heterodimer interface [polypeptide binding]; other site
309798004147	phosphorylation loop region [posttranslational modification]
309798004148	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
309798004149	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
309798004150	alpha subunit interface [polypeptide binding]; other site
309798004151	TPP binding site [chemical binding]; other site
309798004152	heterodimer interface [polypeptide binding]; other site
309798004153	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
309798004154	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
309798004155	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
309798004156	TPP-binding site [chemical binding]; other site
309798004157	tetramer interface [polypeptide binding]; other site
309798004158	heterodimer interface [polypeptide binding]; other site
309798004159	phosphorylation loop region [posttranslational modification]
309798004160	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
309798004161	E3 interaction surface; other site
309798004162	lipoyl attachment site [posttranslational modification]; other site
309798004163	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
309798004164	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
309798004165	Glutamate binding site [chemical binding]; other site
309798004166	NAD binding site [chemical binding]; other site
309798004167	catalytic residues [active]
309798004168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
309798004169	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
309798004170	putative substrate translocation pore; other site
309798004171	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
309798004172	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
309798004173	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
309798004174	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
309798004175	dimer interface [polypeptide binding]; other site
309798004176	active site
309798004177	CoA binding pocket [chemical binding]; other site
309798004178	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
309798004179	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
309798004180	NAD(P) binding site [chemical binding]; other site
309798004181	homotetramer interface [polypeptide binding]; other site
309798004182	homodimer interface [polypeptide binding]; other site
309798004183	active site
309798004184	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798004185	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
309798004186	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
309798004187	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
309798004188	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
309798004189	Walker A/P-loop; other site
309798004190	ATP binding site [chemical binding]; other site
309798004191	Q-loop/lid; other site
309798004192	ABC transporter signature motif; other site
309798004193	Walker B; other site
309798004194	D-loop; other site
309798004195	H-loop/switch region; other site
309798004196	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
309798004197	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
309798004198	Walker A/P-loop; other site
309798004199	ATP binding site [chemical binding]; other site
309798004200	Q-loop/lid; other site
309798004201	ABC transporter signature motif; other site
309798004202	Walker B; other site
309798004203	D-loop; other site
309798004204	H-loop/switch region; other site
309798004205	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
309798004206	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
309798004207	TM-ABC transporter signature motif; other site
309798004208	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
309798004209	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
309798004210	TM-ABC transporter signature motif; other site
309798004211	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
309798004212	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
309798004213	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
309798004214	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
309798004215	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
309798004216	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
309798004217	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
309798004218	putative acyltransferase; Provisional; Region: PRK05790
309798004219	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
309798004220	dimer interface [polypeptide binding]; other site
309798004221	active site
309798004222	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
309798004223	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
309798004224	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
309798004225	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
309798004226	ABC transporter signature motif; other site
309798004227	Walker B; other site
309798004228	D-loop; other site
309798004229	H-loop/switch region; other site
309798004230	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
309798004231	Acyltransferase family; Region: Acyl_transf_3; pfam01757
309798004232	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
309798004233	Predicted permease; Region: DUF318; cl17795
309798004234	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
309798004235	putative Zn2+ binding site [ion binding]; other site
309798004236	putative DNA binding site [nucleotide binding]; other site
309798004237	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
309798004238	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
309798004239	putative active site [active]
309798004240	putative metal binding site [ion binding]; other site
309798004241	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
309798004242	trimer interface [polypeptide binding]; other site
309798004243	putative Zn binding site [ion binding]; other site
309798004244	CRISPR spacer
309798004245	CRISPR spacer
309798004246	CRISPR spacer
309798004247	CRISPR spacer
309798004248	CRISPR spacer
309798004249	CRISPR spacer
309798004250	CRISPR spacer
309798004251	CRISPR spacer
309798004252	CRISPR spacer
309798004253	CRISPR spacer
309798004254	CRISPR spacer
309798004255	CRISPR spacer
309798004256	CRISPR spacer
309798004257	CRISPR spacer
309798004258	CRISPR spacer
309798004259	CRISPR spacer
309798004260	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
309798004261	catalytic residues [active]
309798004262	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
309798004263	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798004264	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
309798004265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798004266	S-adenosylmethionine binding site [chemical binding]; other site
309798004267	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
309798004268	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
309798004269	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
309798004270	HsdM N-terminal domain; Region: HsdM_N; pfam12161
309798004271	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
309798004272	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
309798004273	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
309798004274	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
309798004275	putative Mg++ binding site [ion binding]; other site
309798004276	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
309798004277	nucleotide binding region [chemical binding]; other site
309798004278	ATP-binding site [chemical binding]; other site
309798004279	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
309798004280	CRISPR spacer
309798004281	DNA methylase; Region: N6_N4_Mtase; pfam01555
309798004282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798004283	S-adenosylmethionine binding site [chemical binding]; other site
309798004284	DNA methylase; Region: N6_N4_Mtase; cl17433
309798004285	DpnII restriction endonuclease; Region: DpnII; pfam04556
309798004286	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
309798004287	CRISPR spacer
309798004288	CRISPR spacer
309798004289	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
309798004290	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
309798004291	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798004292	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
309798004293	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
309798004294	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
309798004295	Penicillinase repressor; Region: Pencillinase_R; pfam03965
309798004296	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
309798004297	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
309798004298	Uncharacterized conserved protein [Function unknown]; Region: COG1479
309798004299	Protein of unknown function DUF262; Region: DUF262; pfam03235
309798004300	Uncharacterized conserved protein [Function unknown]; Region: COG3472
309798004301	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
309798004302	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
309798004303	ligand binding site [chemical binding]; other site
309798004304	dimerization interface [polypeptide binding]; other site
309798004305	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
309798004306	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
309798004307	TM-ABC transporter signature motif; other site
309798004308	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
309798004309	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
309798004310	Walker A/P-loop; other site
309798004311	ATP binding site [chemical binding]; other site
309798004312	Q-loop/lid; other site
309798004313	ABC transporter signature motif; other site
309798004314	Walker B; other site
309798004315	D-loop; other site
309798004316	H-loop/switch region; other site
309798004317	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
309798004318	D-ribose pyranase; Provisional; Region: PRK11797
309798004319	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
309798004320	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
309798004321	substrate binding site [chemical binding]; other site
309798004322	dimer interface [polypeptide binding]; other site
309798004323	ATP binding site [chemical binding]; other site
309798004324	Transcriptional regulators [Transcription]; Region: PurR; COG1609
309798004325	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
309798004326	DNA binding site [nucleotide binding]
309798004327	domain linker motif; other site
309798004328	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
309798004329	dimerization interface [polypeptide binding]; other site
309798004330	ligand binding site [chemical binding]; other site
309798004331	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
309798004332	active site
309798004333	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798004334	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
309798004335	catalytic triad [active]
309798004336	putative active site [active]
309798004337	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
309798004338	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798004339	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
309798004340	catalytic triad [active]
309798004341	putative active site [active]
309798004342	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
309798004343	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
309798004344	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
309798004345	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
309798004346	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
309798004347	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
309798004348	active site
309798004349	FMN binding site [chemical binding]; other site
309798004350	substrate binding site [chemical binding]; other site
309798004351	homotetramer interface [polypeptide binding]; other site
309798004352	catalytic residue [active]
309798004353	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
309798004354	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
309798004355	oligomer interface [polypeptide binding]; other site
309798004356	metal binding site [ion binding]; metal-binding site
309798004357	metal binding site [ion binding]; metal-binding site
309798004358	putative Cl binding site [ion binding]; other site
309798004359	aspartate ring; other site
309798004360	basic sphincter; other site
309798004361	hydrophobic gate; other site
309798004362	periplasmic entrance; other site
309798004363	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
309798004364	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
309798004365	asparagine synthetase AsnA; Provisional; Region: PRK05425
309798004366	motif 1; other site
309798004367	dimer interface [polypeptide binding]; other site
309798004368	active site
309798004369	motif 2; other site
309798004370	motif 3; other site
309798004371	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
309798004372	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798004373	S-adenosylmethionine binding site [chemical binding]; other site
309798004374	NADH dehydrogenase subunit M; Validated; Region: PRK08668
309798004375	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
309798004376	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
309798004377	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
309798004378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
309798004379	homodimer interface [polypeptide binding]; other site
309798004380	catalytic residue [active]
309798004381	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
309798004382	Uncharacterized protein involved in the oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrF; COG2923
309798004383	DsrE/DsrF-like family; Region: DrsE; cl00672
309798004384	Sulphur transport; Region: Sulf_transp; pfam04143
309798004385	Sulphur transport; Region: Sulf_transp; pfam04143
309798004386	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
309798004387	CPxP  motif; other site
309798004388	hypothetical protein; Provisional; Region: PRK02947
309798004389	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
309798004390	putative active site [active]
309798004391	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
309798004392	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
309798004393	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
309798004394	active pocket/dimerization site; other site
309798004395	active site
309798004396	phosphorylation site [posttranslational modification]
309798004397	active site
309798004398	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
309798004399	phosphorylation site [posttranslational modification]
309798004400	hypothetical protein; Provisional; Region: PRK02947
309798004401	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
309798004402	putative active site [active]
309798004403	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
309798004404	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
309798004405	active site
309798004406	dimer interface [polypeptide binding]; other site
309798004407	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
309798004408	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
309798004409	active site
309798004410	motif I; other site
309798004411	motif II; other site
309798004412	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
309798004413	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
309798004414	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
309798004415	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
309798004416	dimer interface [polypeptide binding]; other site
309798004417	active site
309798004418	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
309798004419	dimer interface [polypeptide binding]; other site
309798004420	active site
309798004421	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
309798004422	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
309798004423	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
309798004424	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
309798004425	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
309798004426	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
309798004427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
309798004428	S-adenosylmethionine binding site [chemical binding]; other site
309798004429	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
309798004430	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
309798004431	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
309798004432	dimer interface [polypeptide binding]; other site
309798004433	PYR/PP interface [polypeptide binding]; other site
309798004434	TPP binding site [chemical binding]; other site
309798004435	substrate binding site [chemical binding]; other site
309798004436	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
309798004437	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
309798004438	TPP-binding site [chemical binding]; other site
309798004439	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
309798004440	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
309798004441	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
309798004442	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
309798004443	active site
309798004444	peptidase; Reviewed; Region: PRK08554
309798004445	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
309798004446	metal binding site [ion binding]; metal-binding site
309798004447	dimer interface [polypeptide binding]; other site
309798004448	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107
309798004449	Sporulation and spore germination; Region: Germane; pfam10646
309798004450	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
309798004451	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
309798004452	Coenzyme A binding pocket [chemical binding]; other site
309798004453	hypothetical protein; Reviewed; Region: PRK00024
309798004454	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
309798004455	MPN+ (JAMM) motif; other site
309798004456	Zinc-binding site [ion binding]; other site
309798004457	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
309798004458	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
309798004459	active site
309798004460	DNA binding site [nucleotide binding]
309798004461	N-glycosyltransferase; Provisional; Region: PRK11204
309798004462	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
309798004463	DXD motif; other site
309798004464	Cache domain; Region: Cache_1; pfam02743
309798004465	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
309798004466	dimerization interface [polypeptide binding]; other site
309798004467	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
309798004468	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
309798004469	dimer interface [polypeptide binding]; other site
309798004470	putative CheW interface [polypeptide binding]; other site
309798004471	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
309798004472	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
309798004473	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
309798004474	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
309798004475	putative active site [active]
309798004476	Transcriptional regulator [Transcription]; Region: LytR; COG1316
309798004477	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
309798004478	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798004479	FeS/SAM binding site; other site
309798004480	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
309798004481	dimerization interface [polypeptide binding]; other site
309798004482	ATP binding site [chemical binding]; other site
309798004483	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
309798004484	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
309798004485	NodB motif; other site
309798004486	active site
309798004487	catalytic site [active]
309798004488	Cd binding site [ion binding]; other site
309798004489	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
309798004490	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
309798004491	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
309798004492	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
309798004493	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
309798004494	substrate binding site [chemical binding]; other site
309798004495	tetramer interface [polypeptide binding]; other site
309798004496	catalytic residue [active]
309798004497	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
309798004498	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
309798004499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798004500	dimer interface [polypeptide binding]; other site
309798004501	conserved gate region; other site
309798004502	putative PBP binding loops; other site
309798004503	ABC-ATPase subunit interface; other site
309798004504	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
309798004505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
309798004506	dimer interface [polypeptide binding]; other site
309798004507	conserved gate region; other site
309798004508	putative PBP binding loops; other site
309798004509	ABC-ATPase subunit interface; other site
309798004510	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
309798004511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
309798004512	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
309798004513	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
309798004514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
309798004515	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
309798004516	dimer interface [polypeptide binding]; other site
309798004517	putative tRNA-binding site [nucleotide binding]; other site
309798004518	TIGR02688 family protein; Region: TIGR02688
309798004519	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
309798004520	hypothetical protein; Provisional; Region: PRK13795
309798004521	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
309798004522	Active Sites [active]
309798004523	4Fe-4S binding domain; Region: Fer4_6; pfam12837
309798004524	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
309798004525	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
309798004526	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
309798004527	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
309798004528	dimer interface [polypeptide binding]; other site
309798004529	active site
309798004530	glycine loop; other site
309798004531	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
309798004532	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
309798004533	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
309798004534	FeS/SAM binding site; other site
309798004535	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
309798004536	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
309798004537	intersubunit interface [polypeptide binding]; other site
309798004538	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
309798004539	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
309798004540	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
309798004541	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
309798004542	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
309798004543	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
309798004544	Walker A/P-loop; other site
309798004545	ATP binding site [chemical binding]; other site
309798004546	Q-loop/lid; other site
309798004547	ABC transporter signature motif; other site
309798004548	Walker B; other site
309798004549	D-loop; other site
309798004550	H-loop/switch region; other site
309798004551	ribbon-helix-helix domain containing protein; Region: PHA00617
309798004552	PIN domain; Region: PIN_3; cl17397
309798004553	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
309798004554	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
309798004555	Walker A/P-loop; other site
309798004556	ATP binding site [chemical binding]; other site
309798004557	Q-loop/lid; other site
309798004558	ABC transporter signature motif; other site
309798004559	Walker B; other site
309798004560	D-loop; other site
309798004561	H-loop/switch region; other site
309798004562	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
309798004563	classical (c) SDRs; Region: SDR_c; cd05233
309798004564	NAD(P) binding site [chemical binding]; other site
309798004565	active site
309798004566	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
309798004567	active site
309798004568	catalytic triad [active]
309798004569	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
309798004570	hypothetical protein; Provisional; Region: PRK02399
309798004571	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
309798004572	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
309798004573	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
309798004574	Cl- selectivity filter; other site
309798004575	Cl- binding residues [ion binding]; other site
309798004576	pore gating glutamate residue; other site
309798004577	dimer interface [polypeptide binding]; other site
309798004578	H+/Cl- coupling transport residue; other site
309798004579	TrkA-C domain; Region: TrkA_C; pfam02080
309798004580	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
309798004581	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
309798004582	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
309798004583	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
309798004584	Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104
309798004585	charged pocket; other site
309798004586	D-serine dehydratase; Provisional; Region: PRK02991
309798004587	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
309798004588	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
309798004589	catalytic residue [active]
309798004590	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
309798004591	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
309798004592	substrate binding site [chemical binding]; other site
309798004593	ATP binding site [chemical binding]; other site
309798004594	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
309798004595	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
309798004596	dinuclear metal binding motif [ion binding]; other site
309798004597	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
309798004598	S-layer homology domain; Region: SLH; pfam00395
309798004599	S-layer homology domain; Region: SLH; pfam00395
309798004600	S-layer homology domain; Region: SLH; pfam00395
309798004601	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
309798004602	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
309798004603	active site
309798004604	catalytic tetrad [active]
309798004605	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
309798004606	TRAM domain; Region: TRAM; cl01282
309798004607	ERF superfamily; Region: ERF; pfam04404
309798004608	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
309798004609	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
309798004610	FMN binding site [chemical binding]; other site
309798004611	substrate binding site [chemical binding]; other site
309798004612	putative catalytic residue [active]